RPTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)9.97306065
2molting cycle (GO:0042303)9.97306065
3water homeostasis (GO:0030104)8.95617487
4keratinocyte differentiation (GO:0030216)8.94679002
5apical protein localization (GO:0045176)8.65620948
6hemidesmosome assembly (GO:0031581)7.20449740
7bundle of His cell to Purkinje myocyte communication (GO:0086069)7.18390178
8localization within membrane (GO:0051668)6.76331384
9epidermal cell differentiation (GO:0009913)6.62062750
10intermediate filament organization (GO:0045109)6.31270662
11negative regulation of bone mineralization (GO:0030502)6.29683690
12skin morphogenesis (GO:0043589)6.24888980
13membrane raft organization (GO:0031579)6.05250329
14asymmetric protein localization (GO:0008105)5.98021674
15hair cell differentiation (GO:0035315)5.96665438
16long-chain fatty acid biosynthetic process (GO:0042759)5.73639490
17negative regulation of homotypic cell-cell adhesion (GO:0034111)5.55773911
18negative regulation of biomineral tissue development (GO:0070168)5.51199434
19virion attachment to host cell (GO:0019062)5.43779240
20adhesion of symbiont to host cell (GO:0044650)5.43779240
21O-glycan processing (GO:0016266)5.39481838
22epidermis development (GO:0008544)5.33726082
23negative regulation of interleukin-17 production (GO:0032700)5.17051317
24cell wall macromolecule metabolic process (GO:0044036)5.06668404
25cell wall macromolecule catabolic process (GO:0016998)5.06668404
26glucosamine-containing compound catabolic process (GO:1901072)5.04436796
27positive regulation of p38MAPK cascade (GO:1900745)4.64351997
28regulation of hippo signaling (GO:0035330)4.61512123
29linoleic acid metabolic process (GO:0043651)4.57734464
30positive regulation of endothelial cell differentiation (GO:0045603)4.57478951
31positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)4.56471361
32intestinal epithelial cell development (GO:0060576)4.48612283
33adhesion of symbiont to host (GO:0044406)4.41954692
34ectoderm development (GO:0007398)4.39098534
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.30863123
36regulation of protein polyubiquitination (GO:1902914)4.30830658
37intermediate filament cytoskeleton organization (GO:0045104)4.25310960
38fibrinolysis (GO:0042730)4.19734761
39lipoxygenase pathway (GO:0019372)4.14301039
40fatty acid elongation (GO:0030497)4.12396468
41intermediate filament-based process (GO:0045103)4.11552554
42N-terminal protein amino acid acetylation (GO:0006474)4.10230953
43antimicrobial humoral response (GO:0019730)4.08361955
44regulation of platelet aggregation (GO:0090330)4.07706137
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.02390809
46surfactant homeostasis (GO:0043129)3.99496334
47negative regulation of cell-cell adhesion (GO:0022408)3.91408254
48protein O-linked glycosylation (GO:0006493)3.79082995
49interkinetic nuclear migration (GO:0022027)3.77356103
50regulation of mitochondrial depolarization (GO:0051900)3.69648575
51skin development (GO:0043588)3.68854869
52microtubule nucleation (GO:0007020)3.64179584
53hippo signaling (GO:0035329)3.62211817
54early endosome to late endosome transport (GO:0045022)3.60566062
55cytoplasmic mRNA processing body assembly (GO:0033962)3.57341101
56determination of adult lifespan (GO:0008340)3.50457047
57eyelid development in camera-type eye (GO:0061029)3.50381039
58regulation of bile acid biosynthetic process (GO:0070857)3.45064891
59negative regulation of potassium ion transmembrane transport (GO:1901380)3.44230264
60regulation of p38MAPK cascade (GO:1900744)3.41156241
61membrane budding (GO:0006900)3.39383660
62excretion (GO:0007588)3.37869489
63negative regulation of cytokine-mediated signaling pathway (GO:0001960)3.37211714
64nephron tubule formation (GO:0072079)3.34095168
65regulation of cardioblast proliferation (GO:0003264)3.31008361
66regulation of secondary heart field cardioblast proliferation (GO:0003266)3.31008361
67coronary vasculature morphogenesis (GO:0060977)3.30870834
68regulation of cholesterol homeostasis (GO:2000188)3.27615269
69lymph vessel development (GO:0001945)3.26896060
70regulation of integrin-mediated signaling pathway (GO:2001044)3.26571319
71chemical homeostasis within a tissue (GO:0048875)3.22933941
72regulation of keratinocyte differentiation (GO:0045616)3.22476047
73superoxide anion generation (GO:0042554)3.20947279
74negative regulation of DNA repair (GO:0045738)3.20266628
75keratinocyte proliferation (GO:0043616)3.13936976
76vitamin A metabolic process (GO:0006776)3.13560004
77regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12073145
78negative regulation of response to cytokine stimulus (GO:0060761)3.09030022
79lung lobe morphogenesis (GO:0060463)3.08896932
80ventricular cardiac muscle cell action potential (GO:0086005)3.08429453
81endosome organization (GO:0007032)3.08359366
82negative regulation of metanephros development (GO:0072217)3.03887507
83regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.03304326
84mesenchymal cell differentiation involved in kidney development (GO:0072161)3.01501245
85mesenchymal cell differentiation involved in renal system development (GO:2001012)3.01501245
86negative regulation of cell fate specification (GO:0009996)3.00762097
87regulation of endothelial cell differentiation (GO:0045601)3.00321223
88regulation of interleukin-17 production (GO:0032660)3.00057314
89keratinization (GO:0031424)26.0750456
90antigen processing and presentation of endogenous antigen (GO:0019883)2.99542194
91positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.98927725
92embryonic process involved in female pregnancy (GO:0060136)2.98262455
93hypotonic response (GO:0006971)2.96217662
94wound healing (GO:0042060)2.92225945
95macroautophagy (GO:0016236)2.90874114
96negative regulation of platelet activation (GO:0010544)2.90279227
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.86593795
98long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.85090501
99regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.83666741
100skeletal muscle adaptation (GO:0043501)2.82545130
101negative regulation of vascular permeability (GO:0043116)2.81556001
102negative regulation of protein localization to cell surface (GO:2000009)2.80622988
103positive regulation of vasodilation (GO:0045909)2.79762579
104positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.79532818
105trophectodermal cell differentiation (GO:0001829)2.77886418
106positive regulation of monocyte chemotaxis (GO:0090026)2.76073371
107retina homeostasis (GO:0001895)2.75702334
108regulation of stem cell maintenance (GO:2000036)2.75005278
109positive regulation of DNA-templated transcription, initiation (GO:2000144)2.72199670
110atrioventricular valve morphogenesis (GO:0003181)2.72096869
111muscle organ morphogenesis (GO:0048644)2.71670544
112protein localization to endosome (GO:0036010)2.71587204
113positive regulation of chemokine biosynthetic process (GO:0045080)2.69680310
114sodium ion homeostasis (GO:0055078)2.69250696
115histone H3-K4 trimethylation (GO:0080182)2.66586095
116cell-substrate junction assembly (GO:0007044)2.64270849
117negative regulation of cell-substrate adhesion (GO:0010812)2.63410419
118keratinocyte development (GO:0003334)2.62238306
119positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.61664673
120regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.61664673
121cell communication involved in cardiac conduction (GO:0086065)2.61447481
122regulation of cardioblast differentiation (GO:0051890)2.58550253
123epithelial cell-cell adhesion (GO:0090136)2.57768549
124regulation of heart rate by cardiac conduction (GO:0086091)2.57745302
125regulation of RNA export from nucleus (GO:0046831)2.56757899
126fatty-acyl-CoA metabolic process (GO:0035337)2.53537413
127negative regulation of neurotransmitter secretion (GO:0046929)2.53310476
128regulation of skeletal muscle cell differentiation (GO:2001014)2.52524482
129long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.51358059
130primary alcohol catabolic process (GO:0034310)2.50386728
131epithelium development (GO:0060429)2.50027536
132tooth mineralization (GO:0034505)2.49592729
133fatty-acyl-CoA biosynthetic process (GO:0046949)2.49445601
134regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.48860398
135establishment of planar polarity (GO:0001736)2.41855552
136establishment of tissue polarity (GO:0007164)2.41855552
137regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.41680802
138cellular response to calcium ion (GO:0071277)2.40332387
139outer ear morphogenesis (GO:0042473)2.39780471
140negative regulation of cell fate commitment (GO:0010454)2.38677680
141sphingosine metabolic process (GO:0006670)2.38202398
142regulation of ruffle assembly (GO:1900027)2.37646770
143sarcoplasmic reticulum calcium ion transport (GO:0070296)2.33774988
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32209116
145regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.30779034
146positive regulation of cholesterol efflux (GO:0010875)2.27260377
147positive regulation of cholesterol transport (GO:0032376)2.26722031
148positive regulation of sterol transport (GO:0032373)2.26722031
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.26303448
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.26303448
151hormone catabolic process (GO:0042447)2.26117852
152regulation of epidermal cell differentiation (GO:0045604)2.25820289
153regulation of skeletal muscle contraction (GO:0014819)2.25694839
154ethanol metabolic process (GO:0006067)2.25302199
155hair follicle morphogenesis (GO:0031069)2.24165304
156hair cycle process (GO:0022405)2.21383459
157molting cycle process (GO:0022404)2.21383459
158hair follicle development (GO:0001942)2.20143795
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19698872
160negative regulation of keratinocyte proliferation (GO:0010839)2.18002913
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.17023784
162embryonic viscerocranium morphogenesis (GO:0048703)2.16077426
163epithelial cell differentiation (GO:0030855)2.16042070
164regulation of epidermis development (GO:0045682)2.15088147
165regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.14335960
166cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.13850460
167myotube differentiation (GO:0014902)2.13237829
168regulation of monocyte chemotaxis (GO:0090025)2.12147496
169response to vitamin A (GO:0033189)2.10875319
170establishment of skin barrier (GO:0061436)18.4633609
171regulation of water loss via skin (GO:0033561)15.8893474
172multicellular organismal water homeostasis (GO:0050891)10.8048403
173peptide cross-linking (GO:0018149)10.6693972
174desmosome organization (GO:0002934)10.4892165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.68015167
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51684340
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.07760516
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85193458
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68319125
6ZNF263_19887448_ChIP-Seq_K562_Human2.43516934
7FOXM1_26456572_ChIP-Seq_MCF-7_Human2.35841255
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.09102127
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.04460010
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04394157
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.01030862
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.8603751
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94891715
14FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.93146003
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92597537
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89826959
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.87313156
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.85108360
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80580244
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80580244
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79480229
22CTNNB1_20460455_ChIP-Seq_HCT116_Human1.78879935
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73699088
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68629701
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.68389479
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.67460291
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58238380
28NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58079283
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55662686
30* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.54015955
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.53071391
32ERG_20517297_ChIP-Seq_VCAP_Human1.52760112
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52598338
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45984367
35* TP63_23658742_ChIP-Seq_EP156T_Human1.45176762
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44810605
37CTCF_20526341_ChIP-Seq_ESCs_Human1.44455146
38* GATA4_25053715_ChIP-Seq_YYC3_Human1.43576469
39CTCF_27219007_Chip-Seq_Bcells_Human1.41710072
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41304741
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40189373
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.39928839
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.38870899
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38446986
45RACK7_27058665_Chip-Seq_MCF-7_Human1.38100366
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35746555
47TP63_22573176_ChIP-Seq_HFKS_Human1.35298185
48EGR1_19032775_ChIP-ChIP_M12_Human1.34077693
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33954272
50* GATA6_21074721_ChIP-Seq_CACO-2_Human1.33553300
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31554651
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30212275
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30125907
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.29391929
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28848293
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28807043
57SOX2_20726797_ChIP-Seq_SW620_Human1.28782482
58CLOCK_20551151_ChIP-Seq_293T_Human1.26934811
59RXR_22108803_ChIP-Seq_LS180_Human1.26859444
60BCOR_27268052_Chip-Seq_Bcells_Human1.25457690
61* CJUN_26792858_Chip-Seq_BT549_Human1.25041249
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22818118
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21400639
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20965686
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.19540109
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.19516793
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.19329378
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18954798
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18296479
70ATF3_27146783_Chip-Seq_COLON_Human1.17061457
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16910281
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.16719157
73FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.16113594
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14969929
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14531660
76KLF5_25053715_ChIP-Seq_YYC3_Human1.14518638
77PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13995860
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13822653
79* GATA3_24758297_ChIP-Seq_MCF-7_Human1.13407550
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12806725
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12461498
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12123187
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11887512
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11580630
85BCAT_22108803_ChIP-Seq_LS180_Human1.10934319
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10667037
87AR_25329375_ChIP-Seq_VCAP_Human1.07285615
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.06747343
89RUNX_20019798_ChIP-Seq_JUKART_Human1.05746926
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.05640107
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05342860
92TP53_16413492_ChIP-PET_HCT116_Human1.04766948
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04120967
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04120967
95MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.03277425
96LXR_22292898_ChIP-Seq_THP-1_Human1.03232376
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.02747582
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02117712
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02070168
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01793924
101* SMAD4_21799915_ChIP-Seq_A2780_Human1.00496677
102CDX2_22108803_ChIP-Seq_LS180_Human0.98774361
103AHR_22903824_ChIP-Seq_MCF-7_Human0.97382439
104STAT3_23295773_ChIP-Seq_U87_Human0.97157272
105CEBPB_22108803_ChIP-Seq_LS180_Human0.96905578
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96430018
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95558307
108* BRD4_25478319_ChIP-Seq_HGPS_Human0.95512181
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.95241714
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.95241714
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.94997541
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94842050
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94794863
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94794863
115CHD1_26751641_Chip-Seq_LNCaP_Human0.94712158
116SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94709527
117GATA1_22025678_ChIP-Seq_K562_Human0.93276872
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93271297
119GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92947867
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92616601
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92461710
122TP53_18474530_ChIP-ChIP_U2OS_Human0.92453420
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91643897
124E2F1_20622854_ChIP-Seq_HELA_Human0.89805844
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.89148263
126SMC4_20622854_ChIP-Seq_HELA_Human0.88969781
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88154611
128EZH2_27294783_Chip-Seq_ESCs_Mouse0.87858430
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86818197
130BCL6_27268052_Chip-Seq_Bcells_Human0.86262624
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.83389345
132NANOG_20526341_ChIP-Seq_ESCs_Human0.82853615
133TAF2_19829295_ChIP-Seq_ESCs_Human0.82363628
134ELK3_25401928_ChIP-Seq_HUVEC_Human0.81446698
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.80453472
136GATA6_25053715_ChIP-Seq_YYC3_Human0.80176721
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79056295
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78472311
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.78456471
140* OCT1_27270436_Chip-Seq_PROSTATE_Human0.77949386
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.77893586
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77088010
143AR_21572438_ChIP-Seq_LNCaP_Human0.76898823
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.76502200
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76353396
146DROSHA_22980978_ChIP-Seq_HELA_Human0.76189208
147GATA2_19941826_ChIP-Seq_K562_Human0.76036043
148EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75965261
149RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75965261
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.75665025
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75400556
152KDM2B_26808549_Chip-Seq_K562_Human0.74790758
153CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74193616
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74149801
155* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74044469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.85415273
2MP0005275_abnormal_skin_tensile7.23331483
3MP0005501_abnormal_skin_physiology5.33397066
4MP0000579_abnormal_nail_morphology5.16263912
5MP0002254_reproductive_system_inflammat4.75439006
6MP0010234_abnormal_vibrissa_follicle3.83252310
7MP0004043_abnormal_pH_regulation3.68931450
8MP0003705_abnormal_hypodermis_morpholog3.57023845
9MP0001188_hyperpigmentation3.51405035
10MP0004947_skin_inflammation3.24144248
11MP0001216_abnormal_epidermal_layer3.03348594
12MP0010771_integument_phenotype2.91826018
13MP0000383_abnormal_hair_follicle2.85244612
14MP0000467_abnormal_esophagus_morphology2.74881716
15MP0000647_abnormal_sebaceous_gland2.67794785
16MP0002060_abnormal_skin_morphology2.67416180
17MP0010678_abnormal_skin_adnexa2.65369496
18MP0009780_abnormal_chondrocyte_physiolo2.34086032
19MP0000427_abnormal_hair_cycle2.23066263
20MP0003941_abnormal_skin_development2.23061646
21MP0003453_abnormal_keratinocyte_physiol2.16232885
22MP0002234_abnormal_pharynx_morphology2.15693734
23MP0010386_abnormal_urinary_bladder2.13651977
24MP0001346_abnormal_lacrimal_gland2.12802736
25MP0002098_abnormal_vibrissa_morphology2.11481812
26MP0000377_abnormal_hair_follicle2.07990668
27MP0000762_abnormal_tongue_morphology1.97731253
28MP0005451_abnormal_body_composition1.85897751
29MP0004381_abnormal_hair_follicle1.85878056
30MP0003566_abnormal_cell_adhesion1.73004657
31MP0002095_abnormal_skin_pigmentation1.72323633
32MP0001243_abnormal_dermal_layer1.69014168
33MP0009931_abnormal_skin_appearance1.63074766
34MP0004782_abnormal_surfactant_physiolog1.42586021
35MP0004185_abnormal_adipocyte_glucose1.41431764
36MP0003191_abnormal_cellular_cholesterol1.37956814
37MP0001191_abnormal_skin_condition1.37812523
38MP0001851_eye_inflammation1.33862740
39MP0000367_abnormal_coat/_hair1.28347580
40MP0001756_abnormal_urination1.26993633
41MP0005670_abnormal_white_adipose1.25572832
42MP0005503_abnormal_tendon_morphology1.17545001
43MP0000003_abnormal_adipose_tissue1.13312681
44MP0005365_abnormal_bile_salt1.08802481
45MP0001765_abnormal_ion_homeostasis1.07435784
46MP0009115_abnormal_fat_cell1.05382165
47MP0002139_abnormal_hepatobiliary_system1.03518428
48MP0001502_abnormal_circadian_rhythm1.02042318
49MP0001348_abnormal_lacrimal_gland1.01497980
50MP0003567_abnormal_fetal_cardiomyocyte0.94723672
51MP0003828_pulmonary_edema0.92498359
52MP0002166_altered_tumor_susceptibility0.91536191
53MP0010030_abnormal_orbit_morphology0.88804090
54MP0001784_abnormal_fluid_regulation0.81527832
55MP0003252_abnormal_bile_duct0.80698447
56MP0002177_abnormal_outer_ear0.77407654
57MP0001849_ear_inflammation0.75436617
58MP0001853_heart_inflammation0.73959431
59MP0000465_gastrointestinal_hemorrhage0.73355861
60MP0001958_emphysema0.70876819
61MP0000751_myopathy0.70129973
62MP0001879_abnormal_lymphatic_vessel0.69983646
63MP0005646_abnormal_pituitary_gland0.68337971
64MP0005023_abnormal_wound_healing0.67398955
65MP0005409_darkened_coat_color0.65299278
66MP0002877_abnormal_melanocyte_morpholog0.64667887
67MP0010368_abnormal_lymphatic_system0.63431598
68MP0009053_abnormal_anal_canal0.61925360
69MP0002249_abnormal_larynx_morphology0.61839691
70MP0010352_gastrointestinal_tract_polyps0.60558798
71MP0002136_abnormal_kidney_physiology0.59152643
72MP0005636_abnormal_mineral_homeostasis0.58119164
73MP0002108_abnormal_muscle_morphology0.56372536
74MP0008961_abnormal_basal_metabolism0.55914770
75MP0005367_renal/urinary_system_phenotyp0.55715667
76MP0000516_abnormal_urinary_system0.55715667
77MP0000681_abnormal_thyroid_gland0.55109721
78MP0003943_abnormal_hepatobiliary_system0.54724626
79MP0003646_muscle_fatigue0.54663625
80MP0003937_abnormal_limbs/digits/tail_de0.53966944
81MP0008057_abnormal_DNA_replication0.53919761
82MP0002138_abnormal_hepatobiliary_system0.52357567
83MP0006138_congestive_heart_failure0.52291670
84MP0008438_abnormal_cutaneous_collagen0.51922166
85MP0000470_abnormal_stomach_morphology0.51327769
86MP0001340_abnormal_eyelid_morphology0.50213175
87MP0009643_abnormal_urine_homeostasis0.49149653
88MP0003950_abnormal_plasma_membrane0.49103135
89MP0000685_abnormal_immune_system0.49048683
90MP0000733_abnormal_muscle_development0.48426252
91MP0000534_abnormal_ureter_morphology0.47313831
92MP0002006_tumorigenesis0.47020505
93MP0001873_stomach_inflammation0.46563777
94MP0009384_cardiac_valve_regurgitation0.46307021
95MP0000678_abnormal_parathyroid_gland0.45374631
96MP0003183_abnormal_peptide_metabolism0.45193190
97MP0004272_abnormal_basement_membrane0.45190942
98MP0005666_abnormal_adipose_tissue0.44968723
99MP0000371_diluted_coat_color0.43157707
100MP0002876_abnormal_thyroid_physiology0.43127723
101MP0000631_abnormal_neuroendocrine_gland0.42969368
102MP0003938_abnormal_ear_development0.42577116
103MP0002133_abnormal_respiratory_system0.42269719
104MP0005388_respiratory_system_phenotype0.42269719
105MP0003329_amyloid_beta_deposits0.41344141
106MP0000749_muscle_degeneration0.39876998
107MP0005166_decreased_susceptibility_to0.39853061
108MP0010630_abnormal_cardiac_muscle0.39587753
109MP0009046_muscle_twitch0.39104113
110MP0009333_abnormal_splenocyte_physiolog0.39035740
111MP0009379_abnormal_foot_pigmentation0.38112768
112MP0005647_abnormal_sex_gland0.37353402
113MP0000920_abnormal_myelination0.35905476
114MP0002928_abnormal_bile_duct0.35761239
115MP0003935_abnormal_craniofacial_develop0.35307578
116MP0000566_synostosis0.34931313
117MP0003045_fibrosis0.34746374
118MP0003755_abnormal_palate_morphology0.34653438
119MP0001186_pigmentation_phenotype0.34646195
120MP0000627_abnormal_mammary_gland0.34561712
121MP0000613_abnormal_salivary_gland0.33638652
122MP0001177_atelectasis0.33383408
123MP0004197_abnormal_fetal_growth/weight/0.33216698
124MP0003300_gastrointestinal_ulcer0.32963422
125MP0005310_abnormal_salivary_gland0.32151457
126MP0003763_abnormal_thymus_physiology0.30874189
127MP0003075_altered_response_to0.30655392
128MP0005257_abnormal_intraocular_pressure0.29420183
129MP0000747_muscle_weakness0.29196327
130MP0004858_abnormal_nervous_system0.28498733
131MP0000343_altered_response_to0.28493888
132MP0004264_abnormal_extraembryonic_tissu0.28108795
133MP0004885_abnormal_endolymph0.27958240
134MP0004087_abnormal_muscle_fiber0.27554422
135MP0002282_abnormal_trachea_morphology0.27072795
136MP0005076_abnormal_cell_differentiation0.26255781
137MP0003448_altered_tumor_morphology0.25880111
138MP0004130_abnormal_muscle_cell0.25722746
139MP0005193_abnormal_anterior_eye0.23434971
140MP0004510_myositis0.22843056
141MP0000750_abnormal_muscle_regeneration0.22362033
142MP0005375_adipose_tissue_phenotype0.22141866
143MP0002106_abnormal_muscle_physiology0.21849282
144MP0002111_abnormal_tail_morphology0.21722807
145MP0000538_abnormal_urinary_bladder0.21462991
146MP0000759_abnormal_skeletal_muscle0.21010890
147MP0000604_amyloidosis0.20486450
148MP0002972_abnormal_cardiac_muscle0.20000889
149MP0005620_abnormal_muscle_contractility0.19081120

Predicted human phenotypes

RankGene SetZ-score
1Conjunctival hamartoma (HP:0100780)9.33226106
2Abnormality of nail color (HP:0100643)7.98497553
3Palmoplantar hyperkeratosis (HP:0000972)7.88611647
4Pustule (HP:0200039)7.87767852
5Hyperactive renin-angiotensin system (HP:0000841)7.61915178
6Palmar hyperkeratosis (HP:0010765)7.46109641
7Oral leukoplakia (HP:0002745)7.44427478
8Plantar hyperkeratosis (HP:0007556)7.25399210
9Onycholysis (HP:0001806)6.64991441
10Erythroderma (HP:0001019)6.55830830
11Hypotrichosis (HP:0001006)6.38940543
12Hamartoma of the eye (HP:0010568)6.16601446
13Erythema (HP:0010783)6.09112505
14Villous atrophy (HP:0011473)5.63400781
15Abnormality of small intestinal villus morphology (HP:0011472)5.63400781
16Hypokalemic alkalosis (HP:0001949)5.58413141
17Woolly hair (HP:0002224)5.54003490
18Right ventricular cardiomyopathy (HP:0011663)5.49096474
19Pili torti (HP:0003777)5.46584091
20Eczematoid dermatitis (HP:0000976)5.35660713
21Thick nail (HP:0001805)5.32990293
22Increased circulating renin level (HP:0000848)5.18689512
23Hyperkalemia (HP:0002153)5.06881218
24Congenital ichthyosiform erythroderma (HP:0007431)4.60356913
25Gangrene (HP:0100758)4.59116033
26Abnormality of renin-angiotensin system (HP:0000847)4.52558780
27Abnormality of chloride homeostasis (HP:0011422)4.51730087
28Decreased circulating renin level (HP:0003351)4.49256916
29Sparse scalp hair (HP:0002209)4.36161449
30Hyperaldosteronism (HP:0000859)4.34761895
31Abnormal blistering of the skin (HP:0008066)4.10650355
32Renal salt wasting (HP:0000127)4.05099089
33Neonatal hypoglycemia (HP:0001998)3.92817119
34Hypergammaglobulinemia (HP:0010702)3.90437186
35Papillary thyroid carcinoma (HP:0002895)3.87050147
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.81448042
37Alopecia of scalp (HP:0002293)3.80656579
38Fragile nails (HP:0001808)3.79825593
39Brittle hair (HP:0002299)3.72037602
40Chronic bronchitis (HP:0004469)3.71459557
41Milia (HP:0001056)3.69441253
42Follicular hyperkeratosis (HP:0007502)3.48516946
43Palmoplantar keratoderma (HP:0000982)3.40249379
44Nail dystrophy (HP:0008404)3.38890405
45Abnormal hair laboratory examination (HP:0003328)3.35833674
46Corneal erosion (HP:0200020)3.29645677
47Ectropion (HP:0000656)3.17392258
48Metabolic alkalosis (HP:0200114)3.16445075
49Cystic hygroma (HP:0000476)3.02115045
50Abnormality of potassium homeostasis (HP:0011042)3.01231409
51Nasal polyposis (HP:0100582)2.98771732
52Hypomagnesemia (HP:0002917)2.95956915
53Hypohidrosis (HP:0000966)2.79824272
54Verrucae (HP:0200043)2.76865284
55Papilloma (HP:0012740)2.76865284
56Abnormality of the salivary glands (HP:0010286)2.76086316
57Alkalosis (HP:0001948)2.73297996
58Hypokalemia (HP:0002900)2.67691538
59Abnormal pancreas size (HP:0012094)2.65345302
60Pruritus (HP:0000989)2.60801506
61Ventricular tachycardia (HP:0004756)2.56452934
62Oligodontia (HP:0000677)2.52521546
63Tetany (HP:0001281)2.51395896
64Advanced eruption of teeth (HP:0006288)2.50195106
65Absence seizures (HP:0002121)2.49555115
66Hamartoma (HP:0010566)2.46542997
67Abnormality of the nasal mucosa (HP:0000433)2.43802886
68Distal arthrogryposis (HP:0005684)2.38614246
69Furrowed tongue (HP:0000221)2.37769219
70Unilateral renal agenesis (HP:0000122)2.37141369
71Increased connective tissue (HP:0009025)2.36829529
72Hypoplastic labia majora (HP:0000059)2.35440827
73Hyponatremia (HP:0002902)2.34676213
74Hyporeflexia of lower limbs (HP:0002600)2.33951608
75Type 1 muscle fiber predominance (HP:0003803)2.32479656
76Abnormality of magnesium homeostasis (HP:0004921)2.31218510
77Adrenal overactivity (HP:0002717)2.30442814
78Fatigable weakness (HP:0003473)2.25925663
79Abnormality of the neuromuscular junction (HP:0003398)2.25925663
80Sparse eyelashes (HP:0000653)2.25628788
81Asymmetry of the thorax (HP:0001555)2.25331031
82Natal tooth (HP:0000695)2.21877564
83Lip pit (HP:0100267)2.21674988
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18609864
85Thyroid carcinoma (HP:0002890)2.14955355
86Round ear (HP:0100830)2.14652263
87Ridged nail (HP:0001807)2.13549041
88Abnormality of the labia majora (HP:0012881)2.12962469
89Melanocytic nevus (HP:0000995)2.12880638
90Atrophic scars (HP:0001075)2.11228416
91Muscle fiber inclusion bodies (HP:0100299)2.10986310
92Acute myeloid leukemia (HP:0004808)2.10217608
93Abnormality of sodium homeostasis (HP:0010931)2.10172786
94Nemaline bodies (HP:0003798)2.09750287
95Low posterior hairline (HP:0002162)2.08451702
96Autoamputation (HP:0001218)2.07493984
97Laryngomalacia (HP:0001601)2.05068068
98Abnormality of the fingertips (HP:0001211)2.03045457
99Hip dysplasia (HP:0001385)2.02887455
100Genetic anticipation (HP:0003743)2.02115570
101Curly hair (HP:0002212)2.01450510
102Abnormality of the gastric mucosa (HP:0004295)2.01000946
103Increased IgE level (HP:0003212)12.5255210
104Distal lower limb muscle weakness (HP:0009053)1.99191396
105Hyperhidrosis (HP:0000975)1.97714475
106Fine hair (HP:0002213)1.97074044
107Difficulty running (HP:0009046)1.96315438
108Interstitial pulmonary disease (HP:0006530)1.94576776
109Skin pits (HP:0100276)1.93108066
110Malnutrition (HP:0004395)1.88195768
111Labial hypoplasia (HP:0000066)1.86918048
112Emphysema (HP:0002097)1.85580991
113Lack of skin elasticity (HP:0100679)1.85492052
114Bilateral sensorineural hearing impairment (HP:0008619)1.84770579
115Absent eyelashes (HP:0000561)1.82954863
116Myopathic facies (HP:0002058)1.82584022
117Keratoconjunctivitis (HP:0001096)1.82552363
118Thoracolumbar scoliosis (HP:0002944)1.81440276
119Dialeptic seizures (HP:0011146)1.81406515
120Exercise-induced myalgia (HP:0003738)1.80854686
121Abnormality of the axillary hair (HP:0100134)1.78977628
122Abnormality of secondary sexual hair (HP:0009888)1.78977628
123Polyuria (HP:0000103)1.76056341
124Anonychia (HP:0001798)1.74280579
125Skin ulcer (HP:0200042)1.74212624
126Thickened nuchal skin fold (HP:0000474)1.73185487
127Ventricular fibrillation (HP:0001663)1.72036912
128Ulnar deviation of the wrist (HP:0003049)1.71065920
129Oligodactyly (hands) (HP:0001180)1.70577101
130Double outlet right ventricle (HP:0001719)1.69334283
131Congenital malformation of the right heart (HP:0011723)1.69334283
132Urticaria (HP:0001025)1.68681964
133Hypoplastic female external genitalia (HP:0012815)1.67155225
134Long eyelashes (HP:0000527)1.66657251
135Abnormality of the fingernails (HP:0001231)1.65972296
136Distal lower limb amyotrophy (HP:0008944)1.65163825
137Nephrocalcinosis (HP:0000121)1.63721627
138Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.63213975
139Prominent nose (HP:0000448)1.59397432
140Cholelithiasis (HP:0001081)1.59216696
141Hoarse voice (HP:0001609)1.58839704
142Diastasis recti (HP:0001540)1.58208654
143Paralysis (HP:0003470)1.57270640
144Urethral obstruction (HP:0000796)1.56932756
145Polydipsia (HP:0001959)1.55299957
146Abnormal drinking behavior (HP:0030082)1.55299957
147Abnormality of the columella (HP:0009929)1.55115832
148Asthma (HP:0002099)1.54928313
149Blepharitis (HP:0000498)1.53185771
150Calcaneovalgus deformity (HP:0001848)1.52731123
151Corneal dystrophy (HP:0001131)1.50154666
152Acanthosis nigricans (HP:0000956)1.47405373
153Sudden death (HP:0001699)1.46044209
154Absent phalangeal crease (HP:0006109)1.44246817
155Abnormality of the aortic arch (HP:0012303)1.43962057
156Abnormal gallbladder morphology (HP:0012437)1.41642233
157Exercise-induced muscle cramps (HP:0003710)1.41398670
158Frequent falls (HP:0002359)1.39274299
159Muscle fiber splitting (HP:0003555)1.36151388
160Neonatal death (HP:0003811)1.36114553
161Parakeratosis (HP:0001036)1.32128041
162Dehydration (HP:0001944)1.31600351
163Neck muscle weakness (HP:0000467)1.30958114
164Deformed tarsal bones (HP:0008119)1.30402939
165Hematochezia (HP:0002573)1.29505047
166Osteolytic defects of the hand bones (HP:0009699)1.28496265
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.28496265
168Hypoplasia of dental enamel (HP:0006297)1.27669874
169Achilles tendon contracture (HP:0001771)1.27316091
170Lower limb amyotrophy (HP:0007210)1.27155774
171Scapular winging (HP:0003691)1.27106986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.49948229
2TTN4.97579318
3CAMK1D4.92845586
4STK394.36969412
5WNK44.24108826
6CAMK1G4.11751614
7FER4.05455591
8WNK13.57384928
9SGK23.30852805
10FGFR13.21262056
11SGK33.11388242
12MAPKAPK32.75127347
13EPHB12.56335359
14SGK2232.51883662
15SGK4942.51883662
16MAP3K32.41955971
17TRIB32.37022951
18MST1R2.36648996
19PIK3CG2.35941739
20EPHA22.28976804
21EPHA32.18092485
22FGFR42.11361322
23STK241.99649206
24OXSR11.96834253
25ERN11.85603048
26MAP3K91.82448960
27MAP3K21.73543089
28NME11.69187688
29WNK31.60255701
30RIPK11.59436114
31PTK61.57293354
32LRRK21.53066034
33TAOK11.51557833
34LATS11.51082701
35BCR1.50938867
36MAP2K31.41480041
37MARK21.36963984
38FGFR31.35298947
39EPHB21.35214074
40RPS6KB21.31904124
41MAP3K71.30578068
42STK31.29536664
43OBSCN1.23316205
44MAP3K121.18738894
45MAP3K141.18677336
46MST41.18466930
47FGFR21.17610903
48CDK121.16659578
49AKT31.12019370
50PRKAA21.08161178
51FGR1.08085869
52TYK21.06377221
53PDGFRA1.06266311
54TGFBR21.05391549
55DDR20.96946549
56MET0.94581149
57MAP3K110.94412563
58AKT20.94240724
59PTK20.91146821
60MAP2K60.90694161
61STK380.88559940
62JAK10.87033751
63MAP3K10.85472384
64PKN20.84747772
65PIK3CA0.81787870
66MAP3K60.80230174
67PHKG20.79844101
68PHKG10.79844101
69MTOR0.79069969
70DMPK0.78368855
71RPS6KB10.77127170
72SGK10.76966173
73CHUK0.76590155
74MAP2K40.75425467
75CAMK40.72980913
76DAPK20.72761811
77MAPKAPK20.71916528
78CDK90.69744674
79NTRK20.67972192
80MAP3K40.67966444
81CDK60.66457081
82JAK30.66213478
83PINK10.65463631
84PRKD10.64210229
85PAK40.63588053
86TRPM70.63555971
87CSNK1A1L0.62730299
88TYRO30.62708936
89DYRK1B0.60909445
90ERBB30.60819204
91KSR20.60789711
92MELK0.59346459
93TBK10.58994466
94STK100.58949047
95CDK30.58786284
96MAP2K10.57845692
97RET0.57693998
98NEK10.57647489
99PRKD30.56809880
100RPS6KA20.54313795
101ICK0.53512964
102HIPK20.52924395
103EEF2K0.52917253
104IRAK10.52231870
105STK38L0.52228008
106NUAK10.50477756
107BRD40.49982998
108CDC42BPA0.49417575
109PAK30.48395947
110CAMK10.48114519
111JAK20.46601339
112CSK0.46258486
113TESK10.45360034
114MATK0.44687093
115NLK0.42440115
116MAPKAPK50.41740259
117BMX0.41106857
118LATS20.40597884
119ERBB20.40540667
120PDK40.39312595
121PDK30.39312595
122PRKCH0.38785145
123SIK10.37455491
124FYN0.37074571
125DYRK30.35997932
126MAPK10.35982505
127AURKB0.35841969
128ITK0.35396488
129TGFBR10.34863827
130ATM0.34227653
131ROCK20.33921352
132SRC0.33683239
133PDGFRB0.33394061
134EGFR0.31522231
135IRAK20.31155175
136PKN10.31062928
137PRKCZ0.30791240
138PAK20.30230136
139SCYL20.29999320
140LIMK10.29183131
141AKT10.28950340
142MAPK110.28834552
143PRKAA10.28395329
144IKBKE0.28034504
145GSK3A0.27686029
146SIK30.27451296
147HCK0.26827132
148PDK20.26775749
149MAPK120.26375947
150RPS6KA10.25818242
151GSK3B0.25714504
152ROCK10.25554943
153MAPK30.25435751
154TEC0.25216804
155ZAP700.23964566
156TAOK30.22580208
157RPS6KA30.22169442
158PRKCQ0.19452508
159STK110.18917818
160PNCK0.18295167
161BMPR1B0.18003009
162CSNK1E0.17685264
163PRKCE0.15776495
164MAPK100.15286938
165MAPK140.15142261

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047104.36991170
2Phenylalanine metabolism_Homo sapiens_hsa003603.13490055
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90454549
4Collecting duct acid secretion_Homo sapiens_hsa049662.67622543
5Histidine metabolism_Homo sapiens_hsa003402.49851907
6Salivary secretion_Homo sapiens_hsa049702.40467894
7Fatty acid elongation_Homo sapiens_hsa000622.24682960
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15903701
9Thyroid cancer_Homo sapiens_hsa052162.13354547
10Notch signaling pathway_Homo sapiens_hsa043302.09374960
11Renal cell carcinoma_Homo sapiens_hsa052112.08994692
12Fat digestion and absorption_Homo sapiens_hsa049752.04137511
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01036006
14Linoleic acid metabolism_Homo sapiens_hsa005911.98927592
15Vibrio cholerae infection_Homo sapiens_hsa051101.78033809
16Staphylococcus aureus infection_Homo sapiens_hsa051501.67759272
17Phototransduction_Homo sapiens_hsa047441.65813476
18Tyrosine metabolism_Homo sapiens_hsa003501.64984049
19Lysine degradation_Homo sapiens_hsa003101.62439590
20GnRH signaling pathway_Homo sapiens_hsa049121.57487595
21Arachidonic acid metabolism_Homo sapiens_hsa005901.51824835
22ECM-receptor interaction_Homo sapiens_hsa045121.47564506
23VEGF signaling pathway_Homo sapiens_hsa043701.46411889
24Pertussis_Homo sapiens_hsa051331.42956799
25Renin secretion_Homo sapiens_hsa049241.41938683
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41108469
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35775397
28Prostate cancer_Homo sapiens_hsa052151.32296029
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32163164
30Chronic myeloid leukemia_Homo sapiens_hsa052201.31885404
31Endocytosis_Homo sapiens_hsa041441.31277736
32Olfactory transduction_Homo sapiens_hsa047401.30921675
33Adherens junction_Homo sapiens_hsa045201.28838648
34Gastric acid secretion_Homo sapiens_hsa049711.27501700
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26993936
36Endometrial cancer_Homo sapiens_hsa052131.26401515
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21212075
38FoxO signaling pathway_Homo sapiens_hsa040681.19258147
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.18962319
40Ether lipid metabolism_Homo sapiens_hsa005651.17436066
41Tight junction_Homo sapiens_hsa045301.13949334
42Glioma_Homo sapiens_hsa052141.11814534
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09050499
44ErbB signaling pathway_Homo sapiens_hsa040121.09008671
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08068061
46beta-Alanine metabolism_Homo sapiens_hsa004101.08045611
47Amoebiasis_Homo sapiens_hsa051461.07286961
48TGF-beta signaling pathway_Homo sapiens_hsa043501.06912375
49Wnt signaling pathway_Homo sapiens_hsa043101.06334678
50Prolactin signaling pathway_Homo sapiens_hsa049171.03103598
51Inositol phosphate metabolism_Homo sapiens_hsa005621.01379134
52Hepatitis C_Homo sapiens_hsa051601.01374617
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.00628999
54Caffeine metabolism_Homo sapiens_hsa002320.98900306
55Toxoplasmosis_Homo sapiens_hsa051450.98119412
56Long-term potentiation_Homo sapiens_hsa047200.97849717
57Chemical carcinogenesis_Homo sapiens_hsa052040.97736074
58Steroid biosynthesis_Homo sapiens_hsa001000.97548008
59Proteoglycans in cancer_Homo sapiens_hsa052050.96665616
60Melanogenesis_Homo sapiens_hsa049160.94864960
61Focal adhesion_Homo sapiens_hsa045100.93183283
62Sulfur metabolism_Homo sapiens_hsa009200.92692074
63Fatty acid biosynthesis_Homo sapiens_hsa000610.91854678
64Estrogen signaling pathway_Homo sapiens_hsa049150.91172354
65Synaptic vesicle cycle_Homo sapiens_hsa047210.91168027
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90703241
67Choline metabolism in cancer_Homo sapiens_hsa052310.90612573
68Fatty acid degradation_Homo sapiens_hsa000710.90291877
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90044970
70Non-small cell lung cancer_Homo sapiens_hsa052230.84320150
71Sphingolipid metabolism_Homo sapiens_hsa006000.82958552
72Axon guidance_Homo sapiens_hsa043600.82213041
73Glycerolipid metabolism_Homo sapiens_hsa005610.81997746
74Pancreatic cancer_Homo sapiens_hsa052120.81567141
75PPAR signaling pathway_Homo sapiens_hsa033200.81383070
76Dorso-ventral axis formation_Homo sapiens_hsa043200.79446255
77ABC transporters_Homo sapiens_hsa020100.79092247
78Dilated cardiomyopathy_Homo sapiens_hsa054140.78703259
79MAPK signaling pathway_Homo sapiens_hsa040100.78178786
80Oxytocin signaling pathway_Homo sapiens_hsa049210.77597167
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77143097
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75911720
83Tuberculosis_Homo sapiens_hsa051520.74709896
84Pathways in cancer_Homo sapiens_hsa052000.74362709
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73553686
86Rap1 signaling pathway_Homo sapiens_hsa040150.73514380
87T cell receptor signaling pathway_Homo sapiens_hsa046600.72373335
88Glucagon signaling pathway_Homo sapiens_hsa049220.70705043
89Colorectal cancer_Homo sapiens_hsa052100.69871241
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69677046
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69544492
92Ras signaling pathway_Homo sapiens_hsa040140.69498002
93Small cell lung cancer_Homo sapiens_hsa052220.69301333
94mTOR signaling pathway_Homo sapiens_hsa041500.68008817
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66872129
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.66435025
97Insulin resistance_Homo sapiens_hsa049310.65811990
98AMPK signaling pathway_Homo sapiens_hsa041520.64737145
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64295349
100Shigellosis_Homo sapiens_hsa051310.64243959
101B cell receptor signaling pathway_Homo sapiens_hsa046620.64047909
102Amphetamine addiction_Homo sapiens_hsa050310.63334830
103Platelet activation_Homo sapiens_hsa046110.63009476
104cAMP signaling pathway_Homo sapiens_hsa040240.62952273
105Chemokine signaling pathway_Homo sapiens_hsa040620.62786600
106Influenza A_Homo sapiens_hsa051640.62053612
107Acute myeloid leukemia_Homo sapiens_hsa052210.61300206
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.61146546
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.60975003
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60849030
111Circadian entrainment_Homo sapiens_hsa047130.60802188
112Long-term depression_Homo sapiens_hsa047300.60112817
113Bladder cancer_Homo sapiens_hsa052190.59587500
114Hippo signaling pathway_Homo sapiens_hsa043900.59554372
115Arginine biosynthesis_Homo sapiens_hsa002200.59357174
116Mineral absorption_Homo sapiens_hsa049780.59165293
117Antigen processing and presentation_Homo sapiens_hsa046120.58909215
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58655987
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.57987964
120Calcium signaling pathway_Homo sapiens_hsa040200.57403421
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56326169
122Insulin signaling pathway_Homo sapiens_hsa049100.55299283
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54181151
124Basal cell carcinoma_Homo sapiens_hsa052170.54056958
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53508510
126Hepatitis B_Homo sapiens_hsa051610.52192779
127Nitrogen metabolism_Homo sapiens_hsa009100.52192504
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52154988
129Serotonergic synapse_Homo sapiens_hsa047260.51399970
130Hedgehog signaling pathway_Homo sapiens_hsa043400.51311565
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51221688
132Gap junction_Homo sapiens_hsa045400.50716685
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.50593242
134Primary immunodeficiency_Homo sapiens_hsa053400.50220909
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50065096
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50058892
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48797827
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.46399272
139Osteoclast differentiation_Homo sapiens_hsa043800.45864386
140Pancreatic secretion_Homo sapiens_hsa049720.45526995
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45318303
142Salmonella infection_Homo sapiens_hsa051320.44287566
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43671421
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43523195
145Tryptophan metabolism_Homo sapiens_hsa003800.42894042
146Ovarian steroidogenesis_Homo sapiens_hsa049130.42681982
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42382381
148Fatty acid metabolism_Homo sapiens_hsa012120.41077587
149MicroRNAs in cancer_Homo sapiens_hsa052060.39505774
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39494985
151TNF signaling pathway_Homo sapiens_hsa046680.37972227
152Malaria_Homo sapiens_hsa051440.36701387
153African trypanosomiasis_Homo sapiens_hsa051430.36585222

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