RPS7P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)8.72705875
2ribosomal small subunit assembly (GO:0000028)8.72388753
3ribosomal small subunit biogenesis (GO:0042274)8.63740931
4viral transcription (GO:0019083)8.58633065
5translational termination (GO:0006415)8.21123361
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.00910321
7chaperone-mediated protein transport (GO:0072321)6.93452503
8cotranslational protein targeting to membrane (GO:0006613)6.88763669
9protein targeting to ER (GO:0045047)6.84549032
10translational elongation (GO:0006414)6.79986903
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.58777065
12protein localization to endoplasmic reticulum (GO:0070972)6.43377619
13viral life cycle (GO:0019058)6.26245541
14cellular protein complex disassembly (GO:0043624)6.21254333
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.98675262
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.68188618
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.62363431
18ATP synthesis coupled proton transport (GO:0015986)5.62363431
19translational initiation (GO:0006413)5.50948420
20protein neddylation (GO:0045116)5.19666843
21protein complex disassembly (GO:0043241)5.17161607
22translation (GO:0006412)5.08429460
23ribosomal large subunit biogenesis (GO:0042273)5.00143724
24macromolecular complex disassembly (GO:0032984)4.92738588
25ribonucleoprotein complex biogenesis (GO:0022613)4.87144320
26protein targeting to membrane (GO:0006612)4.57210375
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.51249431
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.48832223
29behavioral response to nicotine (GO:0035095)4.44502809
30cellular component biogenesis (GO:0044085)4.43348560
31respiratory electron transport chain (GO:0022904)4.36001002
32electron transport chain (GO:0022900)4.28981021
33NADH dehydrogenase complex assembly (GO:0010257)4.27040938
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.27040938
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.27040938
36proteasome assembly (GO:0043248)4.22797187
37protein complex biogenesis (GO:0070271)4.15671220
38DNA damage response, detection of DNA damage (GO:0042769)4.14514940
39nuclear-transcribed mRNA catabolic process (GO:0000956)4.09207525
40DNA deamination (GO:0045006)4.01886775
41regulation of mitochondrial translation (GO:0070129)3.92697191
42mitochondrial respiratory chain complex assembly (GO:0033108)3.92160312
43rRNA processing (GO:0006364)3.90805456
44mRNA catabolic process (GO:0006402)3.85163343
45rRNA metabolic process (GO:0016072)3.75594260
46pseudouridine synthesis (GO:0001522)3.74805875
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71021304
48ribosome biogenesis (GO:0042254)3.58129208
49ncRNA 3-end processing (GO:0043628)3.56089797
50RNA catabolic process (GO:0006401)3.52521475
51GTP biosynthetic process (GO:0006183)3.51172486
52ubiquinone biosynthetic process (GO:0006744)3.44281186
53peptidyl-histidine modification (GO:0018202)3.37453760
54water-soluble vitamin biosynthetic process (GO:0042364)3.28240454
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.26523077
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23296626
57ATP biosynthetic process (GO:0006754)3.18739053
58protein targeting to mitochondrion (GO:0006626)3.17213363
59protein-cofactor linkage (GO:0018065)3.16536007
60hydrogen ion transmembrane transport (GO:1902600)3.15933252
61UTP biosynthetic process (GO:0006228)3.15127561
62pyrimidine nucleotide catabolic process (GO:0006244)3.14162257
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13848822
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13848822
65ubiquinone metabolic process (GO:0006743)3.09358876
66establishment of protein localization to membrane (GO:0090150)3.07563922
67protein targeting (GO:0006605)3.02130045
68myoblast migration (GO:0051451)2.96770063
69nonmotile primary cilium assembly (GO:0035058)2.96375521
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95895432
71establishment of protein localization to mitochondrion (GO:0072655)2.93891848
72chromatin remodeling at centromere (GO:0031055)2.93812157
73respiratory chain complex IV assembly (GO:0008535)2.89841130
74protein localization to mitochondrion (GO:0070585)2.87979621
75cell proliferation in forebrain (GO:0021846)2.86910772
76establishment of protein localization to organelle (GO:0072594)2.79563748
77cardiovascular system development (GO:0072358)2.75786954
78cytochrome complex assembly (GO:0017004)2.74662038
79quinone biosynthetic process (GO:1901663)2.73629717
80RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.72766079
81UTP metabolic process (GO:0046051)2.70828098
82ncRNA processing (GO:0034470)2.70060199
83proton transport (GO:0015992)2.70026203
84pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.69889364
85CTP metabolic process (GO:0046036)2.69145394
86CTP biosynthetic process (GO:0006241)2.69145394
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66878865
88hydrogen transport (GO:0006818)2.62617662
89negative regulation of telomere maintenance (GO:0032205)2.59128230
90termination of RNA polymerase III transcription (GO:0006386)2.58720977
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.58720977
92heart trabecula morphogenesis (GO:0061384)2.58215922
93CENP-A containing nucleosome assembly (GO:0034080)2.57112455
94spliceosomal complex assembly (GO:0000245)2.55276497
95guanosine-containing compound biosynthetic process (GO:1901070)2.54463265
96intracellular protein transmembrane import (GO:0044743)2.53445074
97embryonic body morphogenesis (GO:0010172)2.52921925
98nucleoside triphosphate biosynthetic process (GO:0009142)2.52867991
99substrate-independent telencephalic tangential migration (GO:0021826)2.50379741
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.50379741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.88920647
2EZH2_22144423_ChIP-Seq_EOC_Human4.31382690
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08930956
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.94545449
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42768032
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.21961923
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.14217893
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06580600
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00961522
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.81462870
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55102810
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48504398
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37960640
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37519579
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30917961
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14875424
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13595276
18XRN2_22483619_ChIP-Seq_HELA_Human2.11462591
19VDR_23849224_ChIP-Seq_CD4+_Human2.09699483
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00062573
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87504713
22ZNF274_21170338_ChIP-Seq_K562_Hela1.86503054
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.84183239
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.82473500
25TTF2_22483619_ChIP-Seq_HELA_Human1.75714087
26FOXP3_21729870_ChIP-Seq_TREG_Human1.69024056
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65376210
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62787343
29VDR_22108803_ChIP-Seq_LS180_Human1.60076079
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.58840136
31TP53_22573176_ChIP-Seq_HFKS_Human1.56203454
32GABP_19822575_ChIP-Seq_HepG2_Human1.55945193
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54220079
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.53044860
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51907555
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51815598
37MYC_18940864_ChIP-ChIP_HL60_Human1.49230615
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48899882
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47660094
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.46536886
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45030270
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43556339
43TAF2_19829295_ChIP-Seq_ESCs_Human1.42491020
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42317416
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41513458
46IRF1_19129219_ChIP-ChIP_H3396_Human1.41198056
47SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38858648
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36242990
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28970087
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28933758
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.28239707
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27916378
53ELK1_19687146_ChIP-ChIP_HELA_Human1.26370190
54RNF2_27304074_Chip-Seq_NSC_Mouse1.25368187
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24554682
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.22226313
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.20695260
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20465337
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16151874
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14782273
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.13895019
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11584819
63DCP1A_22483619_ChIP-Seq_HELA_Human1.10670165
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09059660
65CTCF_20526341_ChIP-Seq_ESCs_Human1.08837383
66BCL6_27268052_Chip-Seq_Bcells_Human1.04720763
67NCOR_22424771_ChIP-Seq_293T_Human1.04663244
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02974606
69ERA_21632823_ChIP-Seq_H3396_Human1.02456542
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00517074
71KDM5A_27292631_Chip-Seq_BREAST_Human1.00479630
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99158967
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98631628
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97350393
75E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97175345
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96305233
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95629882
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.95581937
79SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95488480
80FUS_26573619_Chip-Seq_HEK293_Human0.94816776
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92251196
82REST_21632747_ChIP-Seq_MESCs_Mouse0.91526120
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91518548
84RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91076659
85EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91076659
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91051343
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89457168
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.89297574
89EWS_26573619_Chip-Seq_HEK293_Human0.89192472
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89000946
91NANOG_20526341_ChIP-Seq_ESCs_Human0.88791562
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88677340
93E2F1_20622854_ChIP-Seq_HELA_Human0.87604851
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.87072622
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86946575
96FOXP1_21924763_ChIP-Seq_HESCs_Human0.85359420
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84474686
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83774236
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.83600020
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83168447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.26679707
2MP0006292_abnormal_olfactory_placode4.28076404
3MP0002163_abnormal_gland_morphology3.79887118
4MP0004145_abnormal_muscle_electrophysio2.75073015
5MP0003646_muscle_fatigue2.45111819
6MP0005646_abnormal_pituitary_gland2.34210493
7MP0004142_abnormal_muscle_tone2.31074043
8MP0002876_abnormal_thyroid_physiology2.31061715
9MP0005379_endocrine/exocrine_gland_phen2.25270034
10MP0002102_abnormal_ear_morphology2.16636213
11MP0001346_abnormal_lacrimal_gland1.86844391
12MP0006072_abnormal_retinal_apoptosis1.80672446
13MP0002160_abnormal_reproductive_system1.77242443
14MP0001440_abnormal_grooming_behavior1.76418552
15MP0005671_abnormal_response_to1.71883785
16MP0002095_abnormal_skin_pigmentation1.69708219
17MP0003567_abnormal_fetal_cardiomyocyte1.68451789
18MP0002837_dystrophic_cardiac_calcinosis1.61386838
19MP0003938_abnormal_ear_development1.54152650
20MP0008789_abnormal_olfactory_epithelium1.53909576
21MP0002653_abnormal_ependyma_morphology1.52170414
22MP0001529_abnormal_vocalization1.52111504
23MP0001293_anophthalmia1.51792865
24MP0003122_maternal_imprinting1.51164752
25MP0004885_abnormal_endolymph1.50610922
26MP0006036_abnormal_mitochondrial_physio1.50281270
27MP0000049_abnormal_middle_ear1.49448225
28MP0003186_abnormal_redox_activity1.47612199
29MP0005083_abnormal_biliary_tract1.38814204
30MP0008872_abnormal_physiological_respon1.37547030
31MP0001968_abnormal_touch/_nociception1.37473931
32MP0005551_abnormal_eye_electrophysiolog1.35065831
33MP0001905_abnormal_dopamine_level1.34859422
34MP0002277_abnormal_respiratory_mucosa1.30710185
35MP0010030_abnormal_orbit_morphology1.28223164
36MP0005389_reproductive_system_phenotype1.27316104
37MP0005670_abnormal_white_adipose1.26562111
38MP0001986_abnormal_taste_sensitivity1.21845746
39MP0002733_abnormal_thermal_nociception1.20862884
40MP0002272_abnormal_nervous_system1.19461040
41MP0005195_abnormal_posterior_eye1.18396847
42MP0003786_premature_aging1.16798556
43MP0009046_muscle_twitch1.13987877
44MP0003693_abnormal_embryo_hatching1.13970521
45MP0006276_abnormal_autonomic_nervous1.12452979
46MP0005377_hearing/vestibular/ear_phenot1.09682796
47MP0003878_abnormal_ear_physiology1.09682796
48MP0009053_abnormal_anal_canal1.08354704
49MP0005084_abnormal_gallbladder_morpholo1.08293025
50MP0005394_taste/olfaction_phenotype1.08214870
51MP0005499_abnormal_olfactory_system1.08214870
52MP0002234_abnormal_pharynx_morphology1.07711481
53MP0009745_abnormal_behavioral_response1.07380275
54MP0002557_abnormal_social/conspecific_i1.05158608
55MP0008877_abnormal_DNA_methylation1.05113064
56MP0000778_abnormal_nervous_system1.04848096
57MP0002938_white_spotting1.03830315
58MP0000631_abnormal_neuroendocrine_gland1.03676649
59MP0009384_cardiac_valve_regurgitation1.02960446
60MP0003136_yellow_coat_color1.02510604
61MP0009250_abnormal_appendicular_skeleto1.01813337
62MP0001286_abnormal_eye_development1.00230642
63MP0009333_abnormal_splenocyte_physiolog0.98828897
64MP0005365_abnormal_bile_salt0.98364236
65MP0002736_abnormal_nociception_after0.97820054
66MP0001502_abnormal_circadian_rhythm0.97764883
67MP0005645_abnormal_hypothalamus_physiol0.97756315
68MP0004742_abnormal_vestibular_system0.97068654
69MP0005085_abnormal_gallbladder_physiolo0.96936127
70MP0001485_abnormal_pinna_reflex0.95645581
71MP0008995_early_reproductive_senescence0.94347937
72MP0001970_abnormal_pain_threshold0.93586275
73MP0000026_abnormal_inner_ear0.93097559
74MP0003183_abnormal_peptide_metabolism0.92504932
75MP0005360_urolithiasis0.90911150
76MP0000372_irregular_coat_pigmentation0.90312190
77MP0002233_abnormal_nose_morphology0.90267813
78MP0002752_abnormal_somatic_nervous0.89974119
79MP0002210_abnormal_sex_determination0.89833623
80MP0003880_abnormal_central_pattern0.87707742
81MP0005253_abnormal_eye_physiology0.86772919
82MP0008875_abnormal_xenobiotic_pharmacok0.85966562
83MP0005391_vision/eye_phenotype0.85421901
84MP0002138_abnormal_hepatobiliary_system0.84256410
85MP0000015_abnormal_ear_pigmentation0.84024188
86MP0001486_abnormal_startle_reflex0.82944940
87MP0001984_abnormal_olfaction0.82426768
88MP0002063_abnormal_learning/memory/cond0.81614261
89MP0002638_abnormal_pupillary_reflex0.80648541
90MP0006035_abnormal_mitochondrial_morpho0.79541230
91MP0002572_abnormal_emotion/affect_behav0.77533659
92MP0010094_abnormal_chromosome_stability0.77023020
93MP0002064_seizures0.76836126
94MP0003937_abnormal_limbs/digits/tail_de0.75266734
95MP0003942_abnormal_urinary_system0.75025611
96MP0000537_abnormal_urethra_morphology0.74952008
97MP0001663_abnormal_digestive_system0.74551415
98MP0004019_abnormal_vitamin_homeostasis0.72222742
99MP0003635_abnormal_synaptic_transmissio0.69934149
100MP0000955_abnormal_spinal_cord0.69409582

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.28249712
2Acute necrotizing encephalopathy (HP:0006965)5.09434837
3Abnormality of cells of the erythroid lineage (HP:0012130)4.90559596
4Abnormal mitochondria in muscle tissue (HP:0008316)4.53875676
5Macrocytic anemia (HP:0001972)4.38820370
6Acute encephalopathy (HP:0006846)4.27712750
7Progressive macrocephaly (HP:0004481)4.01045037
8Mitochondrial inheritance (HP:0001427)3.79076121
93-Methylglutaconic aciduria (HP:0003535)3.74965172
10Abnormal number of erythroid precursors (HP:0012131)3.73265956
11Increased CSF lactate (HP:0002490)3.66024911
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.50035708
13Pallor (HP:0000980)3.41578023
14Cerebral edema (HP:0002181)3.32923203
15Myokymia (HP:0002411)3.14986275
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14479149
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14479149
18Pendular nystagmus (HP:0012043)2.90410156
19Hepatocellular necrosis (HP:0001404)2.83310269
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80621984
21True hermaphroditism (HP:0010459)2.79171897
22Pancreatic fibrosis (HP:0100732)2.79107325
23Absent thumb (HP:0009777)2.75664969
24Molar tooth sign on MRI (HP:0002419)2.75067423
25Abnormality of midbrain morphology (HP:0002418)2.75067423
26Pancreatic cysts (HP:0001737)2.72790171
27Hepatic necrosis (HP:0002605)2.71620858
28Stenosis of the external auditory canal (HP:0000402)2.70978953
29Increased serum lactate (HP:0002151)2.70315726
30Increased serum pyruvate (HP:0003542)2.59114788
31Abnormality of alanine metabolism (HP:0010916)2.51220085
32Hyperalaninemia (HP:0003348)2.51220085
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51220085
34Optic disc pallor (HP:0000543)2.47030334
35Abnormal rod and cone electroretinograms (HP:0008323)2.45475520
36Increased hepatocellular lipid droplets (HP:0006565)2.44574106
37Degeneration of anterior horn cells (HP:0002398)2.44326562
38Abnormality of the anterior horn cell (HP:0006802)2.44326562
39Leukodystrophy (HP:0002415)2.39947049
40Lipid accumulation in hepatocytes (HP:0006561)2.34666037
41Maternal diabetes (HP:0009800)2.30314884
42Renal Fanconi syndrome (HP:0001994)2.26107656
43Colon cancer (HP:0003003)2.25509461
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24624566
45Hypoplasia of the radius (HP:0002984)2.24309064
46Lactic acidosis (HP:0003128)2.20901837
47Increased IgM level (HP:0003496)2.17118383
48Anencephaly (HP:0002323)2.13870216
49Hyperglycinemia (HP:0002154)2.13434250
50Increased intramyocellular lipid droplets (HP:0012240)2.11376471
51Septo-optic dysplasia (HP:0100842)2.08940403
52Lethargy (HP:0001254)2.08827237
53Abnormality of the renal collecting system (HP:0004742)2.08823929
54Oligodactyly (hands) (HP:0001180)2.08689482
55Nephronophthisis (HP:0000090)2.08199357
56Medial flaring of the eyebrow (HP:0010747)2.07485735
57Abnormality of the labia minora (HP:0012880)2.06194766
58Cleft eyelid (HP:0000625)2.05217114
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03384170
60Poor head control (HP:0002421)2.02343689
61Depressed nasal ridge (HP:0000457)2.01888289
62Rib fusion (HP:0000902)2.01758223
63Oligodactyly (HP:0012165)1.99367909
64Exertional dyspnea (HP:0002875)1.98795993
65Respiratory failure (HP:0002878)1.97912713
66Decreased central vision (HP:0007663)1.96721914
67Progressive microcephaly (HP:0000253)1.96667553
68Hyperthyroidism (HP:0000836)1.95739037
69Exercise intolerance (HP:0003546)1.95656312
70Abnormality of the proximal phalanges of the hand (HP:0009834)1.92815190
71Ectopic kidney (HP:0000086)1.91082464
72Short tibia (HP:0005736)1.88734199
73Hypoplasia of the ulna (HP:0003022)1.88298260
74Dynein arm defect of respiratory motile cilia (HP:0012255)1.86395847
75Absent/shortened dynein arms (HP:0200106)1.86395847
76Abolished electroretinogram (ERG) (HP:0000550)1.85200932
77Abnormality of the renal medulla (HP:0100957)1.84767945
78Forearm undergrowth (HP:0009821)1.84247493
79Duplicated collecting system (HP:0000081)1.83771164
80Sclerocornea (HP:0000647)1.82448884
81Respiratory difficulties (HP:0002880)1.80441773
82Abnormality of renal resorption (HP:0011038)1.80148454
83Cystic liver disease (HP:0006706)1.79867157
84Congenital stationary night blindness (HP:0007642)1.78552705
85X-linked dominant inheritance (HP:0001423)1.78438120
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78175762
87Male pseudohermaphroditism (HP:0000037)1.76957617
88Cerebral hypomyelination (HP:0006808)1.76494927
89Poor suck (HP:0002033)1.76354831
90Limb dystonia (HP:0002451)1.76244038
91Sensory axonal neuropathy (HP:0003390)1.75812844
92Abnormality of glycolysis (HP:0004366)1.75651188
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75123343
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.75057191
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.74094401
96Increased muscle lipid content (HP:0009058)1.73160345
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.72608197
98Patent foramen ovale (HP:0001655)1.72577554
99Type II lissencephaly (HP:0007260)1.72373904
100Increased corneal curvature (HP:0100692)1.72267527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.22400968
2WNK43.89152809
3NME23.67987555
4STK163.47217141
5TLK13.44334607
6BCKDK2.73049286
7PLK42.58347998
8ADRBK22.45633354
9BUB12.21035133
10TIE12.10059230
11GRK12.09035258
12NEK12.01930149
13PRKD31.89214857
14CAMKK21.85468393
15DYRK21.85220699
16VRK21.65798162
17PINK11.65344787
18STK391.63205548
19ZAK1.61244256
20NUAK11.57656107
21PIK3CA1.54542047
22SRPK11.46596406
23VRK11.43224735
24BRSK11.30212336
25CDK191.25971234
26CCNB11.18755059
27EPHA41.18412688
28EPHB21.14745594
29BCR1.04507332
30AURKB1.01905489
31LRRK21.00235886
32PASK0.99800152
33WNK10.97840120
34TXK0.95469602
35PLK30.94134682
36ADRBK10.93470134
37PRKCG0.92981008
38PLK20.92815045
39DAPK30.90434678
40AURKA0.84041885
41CAMK10.82923168
42CAMKK10.81025372
43ILK0.80156185
44CSNK2A20.78792292
45PHKG10.77229452
46PHKG20.77229452
47PRKCQ0.77166370
48PIK3CG0.75116716
49INSRR0.74660608
50CSNK1E0.74252655
51PRKACA0.74205074
52CSNK2A10.69833603
53GRK50.68108199
54PIM10.66744535
55TEC0.66740100
56ABL20.66646249
57CDC70.63792018
58DAPK10.60723640
59CAMK2A0.60644019
60BMPR1B0.59958591
61IKBKB0.59757553
62WNK30.59314992
63PLK10.59230939
64MAP2K70.57939494
65PRKCD0.57733176
66ATR0.57022127
67MAPK150.56883662
68MAP3K90.56155444
69STK110.52577434
70RPS6KA60.49789578
71MUSK0.49766719
72MAPK130.49003755
73CDK40.48741052
74RPS6KA50.48236468
75OBSCN0.47168333
76MAP4K20.45874673
77MARK10.45108278
78CAMK2D0.44727338
79PRKCE0.44386301
80BRSK20.44126082
81CHEK10.43857700
82PRKG10.42920192
83PRKCA0.42705300
84RIPK40.40937774
85MINK10.39938797
86NTRK10.38955947
87MARK30.38888743
88PAK30.38788545
89MAP3K110.38698854
90PRKCH0.38185034
91PIM20.37947733
92TGFBR20.37751782
93CAMK2B0.37236824
94EIF2AK10.36865706
95DYRK1B0.36386956
96BMPR20.36372922
97NTRK20.36003627
98GRK60.35745992
99CAMK2G0.35361356
100MAP2K60.34906217

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.48328569
2Oxidative phosphorylation_Homo sapiens_hsa001904.31593919
3Parkinsons disease_Homo sapiens_hsa050123.78541169
4Sulfur relay system_Homo sapiens_hsa041222.59515496
5One carbon pool by folate_Homo sapiens_hsa006702.55106951
6Proteasome_Homo sapiens_hsa030502.54947369
7Alzheimers disease_Homo sapiens_hsa050102.49800308
8Cardiac muscle contraction_Homo sapiens_hsa042602.48186033
9Huntingtons disease_Homo sapiens_hsa050162.47488169
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.37442090
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29139874
12Protein export_Homo sapiens_hsa030601.92945111
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76534706
14RNA polymerase_Homo sapiens_hsa030201.66309869
15Homologous recombination_Homo sapiens_hsa034401.61886295
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57083456
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53243729
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51392206
19Mismatch repair_Homo sapiens_hsa034301.41978408
20Steroid biosynthesis_Homo sapiens_hsa001001.40381293
21Fanconi anemia pathway_Homo sapiens_hsa034601.32935882
22DNA replication_Homo sapiens_hsa030301.30617957
23Pyrimidine metabolism_Homo sapiens_hsa002401.27278731
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19701362
25Asthma_Homo sapiens_hsa053101.15944721
26Peroxisome_Homo sapiens_hsa041461.15927492
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.14790352
28Primary immunodeficiency_Homo sapiens_hsa053401.12097661
29Spliceosome_Homo sapiens_hsa030401.06572955
30Nitrogen metabolism_Homo sapiens_hsa009101.06122939
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04620804
32Basal transcription factors_Homo sapiens_hsa030221.02688044
33Folate biosynthesis_Homo sapiens_hsa007900.99873829
34RNA degradation_Homo sapiens_hsa030180.98967811
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94816378
36Pyruvate metabolism_Homo sapiens_hsa006200.94101213
37Linoleic acid metabolism_Homo sapiens_hsa005910.92425753
38Nucleotide excision repair_Homo sapiens_hsa034200.91845605
39Retinol metabolism_Homo sapiens_hsa008300.88293940
40Graft-versus-host disease_Homo sapiens_hsa053320.87698082
41Collecting duct acid secretion_Homo sapiens_hsa049660.86454989
42Allograft rejection_Homo sapiens_hsa053300.86343998
43RNA transport_Homo sapiens_hsa030130.85911385
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.82962400
45Autoimmune thyroid disease_Homo sapiens_hsa053200.82714542
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.78423587
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.75645178
48Metabolic pathways_Homo sapiens_hsa011000.74530066
49Systemic lupus erythematosus_Homo sapiens_hsa053220.73204659
50Butanoate metabolism_Homo sapiens_hsa006500.72948321
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72902627
52Chemical carcinogenesis_Homo sapiens_hsa052040.72392885
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71447134
54Fat digestion and absorption_Homo sapiens_hsa049750.70044190
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.69901241
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69813221
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69422322
58Tryptophan metabolism_Homo sapiens_hsa003800.68492008
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66811170
60Nicotine addiction_Homo sapiens_hsa050330.65103655
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63445671
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62952832
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62574032
64Purine metabolism_Homo sapiens_hsa002300.61704663
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61556655
66Arachidonic acid metabolism_Homo sapiens_hsa005900.59874298
67Sulfur metabolism_Homo sapiens_hsa009200.55017167
68Fatty acid degradation_Homo sapiens_hsa000710.54404278
69Olfactory transduction_Homo sapiens_hsa047400.52901253
70Phototransduction_Homo sapiens_hsa047440.51846236
71Glutathione metabolism_Homo sapiens_hsa004800.50828051
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49810859
73Arginine and proline metabolism_Homo sapiens_hsa003300.49259087
74Base excision repair_Homo sapiens_hsa034100.47436399
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45668021
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44971194
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44105479
78Propanoate metabolism_Homo sapiens_hsa006400.43514490
79Hedgehog signaling pathway_Homo sapiens_hsa043400.42996454
80beta-Alanine metabolism_Homo sapiens_hsa004100.42850448
81Type I diabetes mellitus_Homo sapiens_hsa049400.41437042
82Basal cell carcinoma_Homo sapiens_hsa052170.40306924
83p53 signaling pathway_Homo sapiens_hsa041150.35330576
84Tyrosine metabolism_Homo sapiens_hsa003500.35288192
85Caffeine metabolism_Homo sapiens_hsa002320.33935152
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33151835
87Rheumatoid arthritis_Homo sapiens_hsa053230.32875704
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32003264
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31546796
90Vitamin B6 metabolism_Homo sapiens_hsa007500.30759660
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29827496
92Selenocompound metabolism_Homo sapiens_hsa004500.29735280
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27924242
94Arginine biosynthesis_Homo sapiens_hsa002200.27880782
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27420764
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26235801
97Phenylalanine metabolism_Homo sapiens_hsa003600.25825598
98Glycerolipid metabolism_Homo sapiens_hsa005610.23320614
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23221522
100Taste transduction_Homo sapiens_hsa047420.23004674

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