RPS7P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.74497054
2ribosomal small subunit biogenesis (GO:0042274)9.44875435
3translational termination (GO:0006415)9.31841664
4ribosomal small subunit assembly (GO:0000028)8.48608847
5maturation of SSU-rRNA (GO:0030490)8.00500364
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.87766349
7cotranslational protein targeting to membrane (GO:0006613)7.77054640
8translational elongation (GO:0006414)7.75504438
9protein targeting to ER (GO:0045047)7.69936386
10establishment of protein localization to endoplasmic reticulum (GO:0072599)7.35068904
11protein localization to endoplasmic reticulum (GO:0070972)7.21556724
12viral life cycle (GO:0019058)7.07916451
13cellular protein complex disassembly (GO:0043624)7.06587032
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.75865515
15translational initiation (GO:0006413)6.00604738
16protein complex disassembly (GO:0043241)5.92958430
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.65002951
18ATP synthesis coupled proton transport (GO:0015986)5.65002951
19macromolecular complex disassembly (GO:0032984)5.59734841
20protein targeting to membrane (GO:0006612)5.26160498
21ribosomal large subunit biogenesis (GO:0042273)5.20708462
22protein neddylation (GO:0045116)4.93150923
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.85809978
24nuclear-transcribed mRNA catabolic process (GO:0000956)4.70107974
25translation (GO:0006412)4.62196574
26ribonucleoprotein complex biogenesis (GO:0022613)4.59149955
27chaperone-mediated protein transport (GO:0072321)4.53157810
28mRNA catabolic process (GO:0006402)4.43552736
29behavioral response to nicotine (GO:0035095)4.39291337
30cellular component biogenesis (GO:0044085)4.11058146
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.10784055
32NADH dehydrogenase complex assembly (GO:0010257)4.10784055
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10784055
34DNA deamination (GO:0045006)3.99408113
35RNA catabolic process (GO:0006401)3.96712732
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95019190
37GTP biosynthetic process (GO:0006183)3.91921266
38protein complex biogenesis (GO:0070271)3.82868190
39electron transport chain (GO:0022900)3.73483831
40cell proliferation in forebrain (GO:0021846)3.72819246
41respiratory electron transport chain (GO:0022904)3.71423491
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57531100
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.50398790
44establishment of protein localization to membrane (GO:0090150)3.50016245
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.47751139
46mitochondrial respiratory chain complex assembly (GO:0033108)3.43599723
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.41078725
48ATP biosynthetic process (GO:0006754)3.37286429
49substrate-independent telencephalic tangential migration (GO:0021826)3.36471618
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.36471618
51protein targeting (GO:0006605)3.30940477
52UTP biosynthetic process (GO:0006228)3.29244136
53regulation of cellular respiration (GO:0043457)3.18220222
54positive regulation of prostaglandin secretion (GO:0032308)3.18092173
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08857222
56establishment of protein localization to organelle (GO:0072594)3.08483792
57negative regulation of mast cell activation (GO:0033004)3.08225194
58rRNA processing (GO:0006364)3.07171709
59UTP metabolic process (GO:0046051)3.05300446
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04649241
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04649241
62ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00530142
63rRNA metabolic process (GO:0016072)3.00437372
64positive regulation of fatty acid transport (GO:2000193)2.99037635
65respiratory chain complex IV assembly (GO:0008535)2.97159458
66positive regulation of icosanoid secretion (GO:0032305)2.91884882
67positive regulation of T cell apoptotic process (GO:0070234)2.89238710
68regulation of activation of Janus kinase activity (GO:0010533)2.86526070
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80901051
70somite development (GO:0061053)2.80547105
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78916863
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.78491036
73termination of RNA polymerase III transcription (GO:0006386)2.78491036
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77806054
75ubiquinone biosynthetic process (GO:0006744)2.76374487
76protein localization to membrane (GO:0072657)2.75912021
77positive regulation of respiratory burst (GO:0060267)2.74504475
78sequestering of actin monomers (GO:0042989)2.72825326
79hydrogen ion transmembrane transport (GO:1902600)2.72149033
80neuron fate determination (GO:0048664)2.69681095
81ribosome biogenesis (GO:0042254)2.69498710
82adaptation of signaling pathway (GO:0023058)2.66767427
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66173326
84cytochrome complex assembly (GO:0017004)2.65938267
85parturition (GO:0007567)2.65087447
86pyrimidine nucleotide catabolic process (GO:0006244)2.64418763
87tongue development (GO:0043586)2.63345776
88protein-cofactor linkage (GO:0018065)2.62964973
89CTP metabolic process (GO:0046036)2.60922651
90CTP biosynthetic process (GO:0006241)2.60922651
91cardiovascular system development (GO:0072358)2.58715965
92transmission of nerve impulse (GO:0019226)2.58652597
93water-soluble vitamin biosynthetic process (GO:0042364)2.58364960
94anterograde synaptic vesicle transport (GO:0048490)2.57735523
95ncRNA 3-end processing (GO:0043628)2.57516444
96nonmotile primary cilium assembly (GO:0035058)2.57149966
97motile cilium assembly (GO:0044458)2.54677010
98preassembly of GPI anchor in ER membrane (GO:0016254)2.52468593
99nucleoside triphosphate biosynthetic process (GO:0009142)2.49731906
100platelet dense granule organization (GO:0060155)2.49264596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52909779
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.19476001
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.12896505
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11714253
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05591559
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55071232
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.47530172
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45252324
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.42540781
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.40324595
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15701173
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13827165
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13274965
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.07785285
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00718475
16VDR_22108803_ChIP-Seq_LS180_Human1.99301417
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99251104
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94143514
19ZNF274_21170338_ChIP-Seq_K562_Hela1.91193827
20TTF2_22483619_ChIP-Seq_HELA_Human1.77628180
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.77026890
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73520478
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.72388098
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.72002925
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.71965739
26IRF1_19129219_ChIP-ChIP_H3396_Human1.70153671
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60015000
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56419180
29VDR_23849224_ChIP-Seq_CD4+_Human1.56334083
30XRN2_22483619_ChIP-Seq_HELA_Human1.54639459
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51301407
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49792293
33MYC_18940864_ChIP-ChIP_HL60_Human1.47161849
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46358928
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40534382
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39658007
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.39283174
38TAF2_19829295_ChIP-Seq_ESCs_Human1.38629439
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38216337
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38045678
41ELK1_19687146_ChIP-ChIP_HELA_Human1.36971878
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36646569
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35767600
44FOXP3_21729870_ChIP-Seq_TREG_Human1.34204019
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33055349
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.32226853
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31599470
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30805842
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.28730878
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27400025
51RNF2_27304074_Chip-Seq_NSC_Mouse1.26219766
52NANOG_20526341_ChIP-Seq_ESCs_Human1.24922765
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.24858157
54REST_21632747_ChIP-Seq_MESCs_Mouse1.24448235
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23757857
56NCOR_22424771_ChIP-Seq_293T_Human1.23533821
57TP53_22573176_ChIP-Seq_HFKS_Human1.23007167
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20390723
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.19857108
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18347701
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18193305
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15390929
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15243767
64IGF1R_20145208_ChIP-Seq_DFB_Human1.15061710
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14561283
66ERA_21632823_ChIP-Seq_H3396_Human1.13476207
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13403425
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13003630
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12660652
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12660652
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10950692
72CTCF_20526341_ChIP-Seq_ESCs_Human1.08856002
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07399141
74BCL6_27268052_Chip-Seq_Bcells_Human1.06503827
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06141159
76STAT1_20625510_ChIP-Seq_HELA_Human1.04158373
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.03079266
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02680917
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01813131
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00946079
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00348300
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.00180167
83AR_20517297_ChIP-Seq_VCAP_Human1.00152109
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99169894
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98325410
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.98325410
87EWS_26573619_Chip-Seq_HEK293_Human0.98179021
88GABP_19822575_ChIP-Seq_HepG2_Human0.98137447
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96535219
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95781827
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94951170
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94538471
93SA1_27219007_Chip-Seq_Bcells_Human0.93233440
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93017499
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92979753
96MYC_19829295_ChIP-Seq_ESCs_Human0.91122527
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.90518263
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90461915
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90331052
100P53_21459846_ChIP-Seq_SAOS-2_Human0.89018879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.47481745
2MP0006292_abnormal_olfactory_placode5.35255925
3MP0002102_abnormal_ear_morphology3.30531809
4MP0003646_muscle_fatigue2.75507953
5MP0008789_abnormal_olfactory_epithelium2.65484183
6MP0002837_dystrophic_cardiac_calcinosis2.59087816
7MP0003787_abnormal_imprinting2.58168362
8MP0002163_abnormal_gland_morphology2.46321978
9MP0002653_abnormal_ependyma_morphology2.25309251
10MP0004142_abnormal_muscle_tone2.23537086
11MP0003122_maternal_imprinting2.19969068
12MP0005377_hearing/vestibular/ear_phenot2.19844583
13MP0003878_abnormal_ear_physiology2.19844583
14MP0005394_taste/olfaction_phenotype2.13236266
15MP0005499_abnormal_olfactory_system2.13236266
16MP0000049_abnormal_middle_ear2.11760475
17MP0001968_abnormal_touch/_nociception1.86880554
18MP0005423_abnormal_somatic_nervous1.80773872
19MP0008877_abnormal_DNA_methylation1.71292833
20MP0003880_abnormal_central_pattern1.68236565
21MP0005671_abnormal_response_to1.67339712
22MP0003879_abnormal_hair_cell1.65043679
23MP0004885_abnormal_endolymph1.60191822
24MP0006276_abnormal_autonomic_nervous1.58235077
25MP0003011_delayed_dark_adaptation1.57545989
26MP0005646_abnormal_pituitary_gland1.55728434
27MP0003121_genomic_imprinting1.55049173
28MP0001529_abnormal_vocalization1.49498772
29MP0001348_abnormal_lacrimal_gland1.43910247
30MP0002160_abnormal_reproductive_system1.41973194
31MP0002638_abnormal_pupillary_reflex1.41654781
32MP0005551_abnormal_eye_electrophysiolog1.41364504
33MP0005379_endocrine/exocrine_gland_phen1.40411129
34MP0009053_abnormal_anal_canal1.39887114
35MP0001905_abnormal_dopamine_level1.37299178
36MP0005389_reproductive_system_phenotype1.36213448
37MP0001293_anophthalmia1.32943897
38MP0003123_paternal_imprinting1.31130893
39MP0004145_abnormal_muscle_electrophysio1.22813442
40MP0001485_abnormal_pinna_reflex1.22687137
41MP0001986_abnormal_taste_sensitivity1.21975198
42MP0006072_abnormal_retinal_apoptosis1.18241630
43MP0002272_abnormal_nervous_system1.16622100
44MP0008872_abnormal_physiological_respon1.16200209
45MP0002234_abnormal_pharynx_morphology1.15924588
46MP0003938_abnormal_ear_development1.15897375
47MP0009745_abnormal_behavioral_response1.14888734
48MP0000631_abnormal_neuroendocrine_gland1.14307723
49MP0002138_abnormal_hepatobiliary_system1.13324166
50MP0008775_abnormal_heart_ventricle1.12090497
51MP0001440_abnormal_grooming_behavior1.11535989
52MP0002736_abnormal_nociception_after1.11215166
53MP0008875_abnormal_xenobiotic_pharmacok1.10973476
54MP0000026_abnormal_inner_ear1.09817057
55MP0002184_abnormal_innervation1.08676528
56MP0002095_abnormal_skin_pigmentation1.05626273
57MP0000678_abnormal_parathyroid_gland1.03516193
58MP0004130_abnormal_muscle_cell1.03364822
59MP0002733_abnormal_thermal_nociception1.01785005
60MP0001919_abnormal_reproductive_system1.00838829
61MP0004742_abnormal_vestibular_system1.00374988
62MP0005084_abnormal_gallbladder_morpholo0.98563052
63MP0009333_abnormal_splenocyte_physiolog0.98093938
64MP0003186_abnormal_redox_activity0.97684559
65MP0000778_abnormal_nervous_system0.96993952
66MP0001963_abnormal_hearing_physiology0.96182557
67MP0005195_abnormal_posterior_eye0.95554443
68MP0001970_abnormal_pain_threshold0.94183772
69MP0002557_abnormal_social/conspecific_i0.93325103
70MP0002752_abnormal_somatic_nervous0.91653374
71MP0002938_white_spotting0.88017685
72MP0005174_abnormal_tail_pigmentation0.86944384
73MP0000372_irregular_coat_pigmentation0.86929305
74MP0010030_abnormal_orbit_morphology0.86237256
75MP0003937_abnormal_limbs/digits/tail_de0.85384031
76MP0001286_abnormal_eye_development0.85381031
77MP0001188_hyperpigmentation0.83772069
78MP0002233_abnormal_nose_morphology0.76723998
79MP0003567_abnormal_fetal_cardiomyocyte0.75977119
80MP0002572_abnormal_emotion/affect_behav0.74047587
81MP0005253_abnormal_eye_physiology0.73296057
82MP0003635_abnormal_synaptic_transmissio0.72376442
83MP0002063_abnormal_learning/memory/cond0.72178860
84MP0001324_abnormal_eye_pigmentation0.71952291
85MP0003136_yellow_coat_color0.71433491
86MP0005075_abnormal_melanosome_morpholog0.71071753
87MP0001800_abnormal_humoral_immune0.70992835
88MP0000613_abnormal_salivary_gland0.70761201
89MP0002277_abnormal_respiratory_mucosa0.69971733
90MP0000955_abnormal_spinal_cord0.68760913
91MP0002909_abnormal_adrenal_gland0.67748739
92MP0004133_heterotaxia0.65859843
93MP0005645_abnormal_hypothalamus_physiol0.65798003
94MP0005448_abnormal_energy_balance0.65278303
95MP0009046_muscle_twitch0.62952913
96MP0003119_abnormal_digestive_system0.61885464
97MP0003936_abnormal_reproductive_system0.60314508
98MP0003942_abnormal_urinary_system0.58252566
99MP0000230_abnormal_systemic_arterial0.56159420
100MP0001663_abnormal_digestive_system0.55851376

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.97207411
2Abnormality of cells of the erythroid lineage (HP:0012130)4.93995102
3Macrocytic anemia (HP:0001972)4.52946729
4Acute necrotizing encephalopathy (HP:0006965)4.40792605
5Abnormal number of erythroid precursors (HP:0012131)3.97634522
6Abnormal mitochondria in muscle tissue (HP:0008316)3.93451296
7Mitochondrial inheritance (HP:0001427)3.74925567
8Pallor (HP:0000980)3.68677610
9Acute encephalopathy (HP:0006846)3.61509458
10Pancreatic fibrosis (HP:0100732)3.51460578
11Progressive macrocephaly (HP:0004481)3.48004401
12Congenital stationary night blindness (HP:0007642)3.42777506
13Molar tooth sign on MRI (HP:0002419)3.37332052
14Abnormality of midbrain morphology (HP:0002418)3.37332052
15Pancreatic cysts (HP:0001737)3.31362521
16Increased CSF lactate (HP:0002490)3.31069733
17Hepatocellular necrosis (HP:0001404)3.12706134
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.11476427
19Asplenia (HP:0001746)3.08820000
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.07039728
21True hermaphroditism (HP:0010459)3.06382834
223-Methylglutaconic aciduria (HP:0003535)3.03816484
23Aplasia/Hypoplasia of the spleen (HP:0010451)3.02096115
24Myokymia (HP:0002411)2.84735721
25Chronic hepatic failure (HP:0100626)2.81003973
26Renal Fanconi syndrome (HP:0001994)2.69991519
27Increased hepatocellular lipid droplets (HP:0006565)2.68339381
28Septo-optic dysplasia (HP:0100842)2.68235258
29Abnormal rod and cone electroretinograms (HP:0008323)2.67945824
30Hepatic necrosis (HP:0002605)2.64836776
31Cerebral edema (HP:0002181)2.64500458
32Stenosis of the external auditory canal (HP:0000402)2.54156327
33Cystic liver disease (HP:0006706)2.44571847
34Medial flaring of the eyebrow (HP:0010747)2.44089890
35Pendular nystagmus (HP:0012043)2.43778682
36Nephronophthisis (HP:0000090)2.43589886
37Optic disc pallor (HP:0000543)2.42556618
38Sclerocornea (HP:0000647)2.41394393
39Depressed nasal ridge (HP:0000457)2.40021053
40Lipid accumulation in hepatocytes (HP:0006561)2.35568189
41Absent thumb (HP:0009777)2.34027684
42Abnormality of the phalanges of the 5th finger (HP:0004213)2.31331233
43Increased serum lactate (HP:0002151)2.30572057
44Anencephaly (HP:0002323)2.28736000
45Hypoplasia of the fovea (HP:0007750)2.26101711
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.26101711
47Symphalangism affecting the phalanges of the hand (HP:0009773)2.25378739
48Rib fusion (HP:0000902)2.23300064
49Polydipsia (HP:0001959)2.22683204
50Abnormal drinking behavior (HP:0030082)2.22683204
51Abnormality of alanine metabolism (HP:0010916)2.21675443
52Hyperalaninemia (HP:0003348)2.21675443
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21675443
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.20297542
55Increased intramyocellular lipid droplets (HP:0012240)2.17830533
56Elevated erythrocyte sedimentation rate (HP:0003565)2.16401286
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.09761960
58Absent/shortened dynein arms (HP:0200106)2.09761960
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08530260
60Gait imbalance (HP:0002141)2.08520076
61Maternal diabetes (HP:0009800)2.06097353
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05678873
63Leukodystrophy (HP:0002415)2.05540393
64Abnormal hemoglobin (HP:0011902)2.03166637
65Colon cancer (HP:0003003)2.00663362
66Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99994441
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99994441
68Congenital primary aphakia (HP:0007707)1.98419368
69Lactic acidosis (HP:0003128)1.98264850
70Abnormality of the renal medulla (HP:0100957)1.97347656
71Aplastic anemia (HP:0001915)1.91369826
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90025470
73Porencephaly (HP:0002132)1.89669146
74Abnormality of DNA repair (HP:0003254)1.88874278
75Abnormality of the fovea (HP:0000493)1.88481200
76Abnormality of renal resorption (HP:0011038)1.88294024
77Postaxial foot polydactyly (HP:0001830)1.88184577
78Hypoplasia of the radius (HP:0002984)1.87891833
79Abnormal ciliary motility (HP:0012262)1.87628933
80Absent septum pellucidum (HP:0001331)1.87470963
81Male pseudohermaphroditism (HP:0000037)1.87452135
82Adrenal hypoplasia (HP:0000835)1.86944989
83Abnormal respiratory epithelium morphology (HP:0012253)1.86635019
84Abnormal respiratory motile cilium morphology (HP:0005938)1.86635019
85Abnormal biliary tract physiology (HP:0012439)1.84151170
86Bile duct proliferation (HP:0001408)1.84151170
87Triphalangeal thumb (HP:0001199)1.83585110
88Abnormality of the middle phalanges of the toes (HP:0010183)1.83547078
89Exertional dyspnea (HP:0002875)1.82919559
90Abnormal respiratory motile cilium physiology (HP:0012261)1.82810337
91Nephrogenic diabetes insipidus (HP:0009806)1.81405310
92Occipital encephalocele (HP:0002085)1.81117769
93Hypoplasia of the ulna (HP:0003022)1.79618511
94Tubular atrophy (HP:0000092)1.78157363
95Polyuria (HP:0000103)1.77320114
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.76559144
97Bilateral microphthalmos (HP:0007633)1.76269262
98Anomalous pulmonary venous return (HP:0010772)1.76111023
99Respiratory failure (HP:0002878)1.74102117
100Growth hormone deficiency (HP:0000824)1.73749422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.40741359
2PASK3.21498860
3ADRBK23.14884384
4TLK12.79040170
5WNK42.76041613
6TXK2.60762135
7ZAK2.17521873
8TIE12.16492461
9CDK192.07476443
10MAP4K12.06497088
11GRK12.02529250
12BCKDK1.99975767
13DYRK21.96053737
14LRRK21.91635415
15CAMKK11.89590568
16PIK3CA1.86570404
17LIMK11.68262200
18CAMKK21.62917078
19MAP4K21.52807828
20KDR1.42233664
21CDK81.32201723
22STK391.30729985
23MAP3K91.25251716
24EPHB21.23711503
25PINK11.17297583
26TEC1.16751045
27MAP3K111.16282530
28NME21.11846600
29ADRBK11.08498176
30PDK21.01376600
31NUAK11.01294903
32ABL21.00742902
33NTRK30.99195755
34TAOK30.98513143
35PRKCQ0.98482687
36GRK70.97006477
37WNK30.96521840
38ITK0.93767570
39CDC70.93503704
40SYK0.92398583
41OXSR10.89476714
42PRKCG0.88749377
43CAMK10.87321151
44BTK0.87153389
45FRK0.85874556
46PIM10.84434857
47STK110.84376246
48BLK0.83795956
49BMPR1B0.83534557
50NTRK20.83046882
51TYRO30.82465416
52INSRR0.80603559
53MAPK130.79507435
54PLK40.78041465
55VRK10.77340221
56FES0.74081408
57DYRK30.71959613
58PLK20.70359599
59RPS6KA50.69961757
60NME10.68863142
61IKBKE0.68803551
62EPHA40.68183970
63ERBB20.67810342
64NEK10.66575520
65LYN0.65564632
66AURKA0.65502692
67GRK60.65396661
68CASK0.64721769
69CSNK2A20.64414015
70LCK0.63674708
71MAP3K130.62422927
72IKBKB0.60250567
73PRKACA0.59404815
74MARK30.58901224
75DAPK30.58763467
76PIM20.56404888
77MAP2K70.54190429
78WNK10.53436844
79DYRK1B0.52982857
80VRK20.51490892
81BRAF0.51158418
82NEK20.50865986
83OBSCN0.49716235
84BRSK10.48878792
85RPS6KA60.47603956
86MAP2K40.47123413
87GRK50.46560849
88MAP2K60.46495930
89CAMK1D0.45058821
90AURKB0.43800446
91DYRK1A0.43463241
92CSNK2A10.43256732
93PRKCD0.42421740
94PIK3CG0.42363486
95MAP3K40.40479206
96PRKCA0.40267002
97IRAK40.40128947
98PLK10.39056157
99ARAF0.38961873
100TNK20.38713776

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.00915570
2Oxidative phosphorylation_Homo sapiens_hsa001904.33095879
3Parkinsons disease_Homo sapiens_hsa050123.68872837
4Huntingtons disease_Homo sapiens_hsa050162.48296053
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.48066444
6Cardiac muscle contraction_Homo sapiens_hsa042602.47283377
7Alzheimers disease_Homo sapiens_hsa050102.46615404
8Sulfur relay system_Homo sapiens_hsa041222.43169903
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27624940
10RNA polymerase_Homo sapiens_hsa030202.26286858
11Linoleic acid metabolism_Homo sapiens_hsa005912.17838788
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05060837
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85261933
14Proteasome_Homo sapiens_hsa030501.66181464
15Protein export_Homo sapiens_hsa030601.64931469
16Caffeine metabolism_Homo sapiens_hsa002321.60821033
17Primary immunodeficiency_Homo sapiens_hsa053401.53129503
18Nitrogen metabolism_Homo sapiens_hsa009101.46813154
19Phototransduction_Homo sapiens_hsa047441.46619463
20Asthma_Homo sapiens_hsa053101.44333327
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43117807
22RNA degradation_Homo sapiens_hsa030181.41773170
23Pyrimidine metabolism_Homo sapiens_hsa002401.27329136
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14669758
25Fat digestion and absorption_Homo sapiens_hsa049751.12469072
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09495500
27Basal transcription factors_Homo sapiens_hsa030221.09440604
28Autoimmune thyroid disease_Homo sapiens_hsa053201.05751825
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04162133
30Nicotine addiction_Homo sapiens_hsa050331.02370722
31Allograft rejection_Homo sapiens_hsa053301.01389638
32Fanconi anemia pathway_Homo sapiens_hsa034601.01241364
33Arachidonic acid metabolism_Homo sapiens_hsa005901.00739887
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.00347221
35DNA replication_Homo sapiens_hsa030300.99398947
36Homologous recombination_Homo sapiens_hsa034400.97088499
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95859310
38Ether lipid metabolism_Homo sapiens_hsa005650.92526727
39One carbon pool by folate_Homo sapiens_hsa006700.84676274
40Purine metabolism_Homo sapiens_hsa002300.81753153
41Butanoate metabolism_Homo sapiens_hsa006500.81413779
42Nucleotide excision repair_Homo sapiens_hsa034200.78366962
43Tryptophan metabolism_Homo sapiens_hsa003800.77137416
44Graft-versus-host disease_Homo sapiens_hsa053320.76367003
45Spliceosome_Homo sapiens_hsa030400.75840144
46Hematopoietic cell lineage_Homo sapiens_hsa046400.70798846
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68434014
48Steroid biosynthesis_Homo sapiens_hsa001000.67017144
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63953925
50Metabolic pathways_Homo sapiens_hsa011000.63086009
51Propanoate metabolism_Homo sapiens_hsa006400.62642413
52Olfactory transduction_Homo sapiens_hsa047400.62263373
53Retinol metabolism_Homo sapiens_hsa008300.62245614
54Peroxisome_Homo sapiens_hsa041460.62061245
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61318686
56Morphine addiction_Homo sapiens_hsa050320.61111156
57Chemical carcinogenesis_Homo sapiens_hsa052040.58020958
58Mismatch repair_Homo sapiens_hsa034300.55019083
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.53897470
60T cell receptor signaling pathway_Homo sapiens_hsa046600.52333239
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52095015
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.51201764
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50583637
64Type I diabetes mellitus_Homo sapiens_hsa049400.49418176
65Collecting duct acid secretion_Homo sapiens_hsa049660.49118633
66Systemic lupus erythematosus_Homo sapiens_hsa053220.48853976
67RNA transport_Homo sapiens_hsa030130.47513368
68beta-Alanine metabolism_Homo sapiens_hsa004100.46223973
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45569184
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44697615
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42213931
72Ovarian steroidogenesis_Homo sapiens_hsa049130.41276083
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40335105
74Insulin secretion_Homo sapiens_hsa049110.38652302
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37823156
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34921619
77Basal cell carcinoma_Homo sapiens_hsa052170.32635003
78Rheumatoid arthritis_Homo sapiens_hsa053230.32411346
79Hedgehog signaling pathway_Homo sapiens_hsa043400.32006575
80Tyrosine metabolism_Homo sapiens_hsa003500.30548771
81Glycerolipid metabolism_Homo sapiens_hsa005610.30342675
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29980253
83Regulation of autophagy_Homo sapiens_hsa041400.28631555
84Fatty acid degradation_Homo sapiens_hsa000710.27652828
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.26153571
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.25717396
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25327737
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24885037
89Taste transduction_Homo sapiens_hsa047420.23979134
90Antigen processing and presentation_Homo sapiens_hsa046120.23875434
91Base excision repair_Homo sapiens_hsa034100.23674241
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23645831
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.23440547
94Folate biosynthesis_Homo sapiens_hsa007900.22663578
95Pancreatic secretion_Homo sapiens_hsa049720.19863836
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18002229
97Serotonergic synapse_Homo sapiens_hsa047260.17977105
98Glutamatergic synapse_Homo sapiens_hsa047240.15596657
99Salivary secretion_Homo sapiens_hsa049700.13005927
100Axon guidance_Homo sapiens_hsa043600.10102246

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