RPS6KB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.73013534
2RNA localization (GO:0006403)5.96217975
3signal complex assembly (GO:0007172)5.76926858
4heme biosynthetic process (GO:0006783)5.31915566
5protoporphyrinogen IX biosynthetic process (GO:0006782)5.15650719
6protoporphyrinogen IX metabolic process (GO:0046501)4.98451207
7megakaryocyte development (GO:0035855)4.85267524
8NADH metabolic process (GO:0006734)4.61394198
9fat-soluble vitamin biosynthetic process (GO:0042362)4.58304068
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.55019451
11porphyrin-containing compound biosynthetic process (GO:0006779)4.33100686
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30143018
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30143018
14heme metabolic process (GO:0042168)4.19504174
15GDP-mannose metabolic process (GO:0019673)4.13505866
16pentose-phosphate shunt (GO:0006098)4.10190634
17negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.04453153
18response to pheromone (GO:0019236)4.03198738
19ribosomal small subunit assembly (GO:0000028)4.00306969
20tetrapyrrole biosynthetic process (GO:0033014)3.97008488
21viral transcription (GO:0019083)3.93522988
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.87389826
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.84747992
24regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.77189665
25regulation of necrotic cell death (GO:0010939)3.76211995
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.75565686
27maturation of 5.8S rRNA (GO:0000460)3.74071848
28translational termination (GO:0006415)3.70086029
29negative regulation of cell size (GO:0045792)3.65584370
30antigen processing and presentation of endogenous antigen (GO:0019883)3.61380367
31platelet formation (GO:0030220)3.60357739
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60350450
33chaperone mediated protein folding requiring cofactor (GO:0051085)3.60011267
34regulation of necroptotic process (GO:0060544)3.57007308
35glucose catabolic process (GO:0006007)3.54685057
36amino acid salvage (GO:0043102)3.51779578
37L-methionine salvage (GO:0071267)3.51779578
38L-methionine biosynthetic process (GO:0071265)3.51779578
39translational elongation (GO:0006414)3.50483597
40GMP metabolic process (GO:0046037)3.50143177
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45397919
42porphyrin-containing compound metabolic process (GO:0006778)3.43322496
43NADPH regeneration (GO:0006740)3.42746375
44T cell apoptotic process (GO:0070231)3.42432521
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34906625
46regulation of mitochondrial translation (GO:0070129)3.30945965
47protein insertion into membrane (GO:0051205)3.29238967
48pentose metabolic process (GO:0019321)3.23714362
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22211767
50spliceosomal complex assembly (GO:0000245)3.20614508
51protein targeting to ER (GO:0045047)3.20598372
52cotranslational protein targeting to membrane (GO:0006613)3.19270318
53protein-cofactor linkage (GO:0018065)3.16744269
54necroptotic process (GO:0070266)3.13635347
55S-adenosylmethionine metabolic process (GO:0046500)3.13494766
56rRNA modification (GO:0000154)3.13438989
57thymic T cell selection (GO:0045061)3.12515954
58erythrocyte development (GO:0048821)3.12196733
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09820418
60positive regulation of gamma-delta T cell activation (GO:0046645)3.08959326
61negative regulation of RNA splicing (GO:0033119)3.08713716
62lymphocyte apoptotic process (GO:0070227)3.07984395
63negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.06913969
64proline biosynthetic process (GO:0006561)3.06538710
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02328382
66positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.01590759
67positive regulation of B cell differentiation (GO:0045579)3.01410347
68protein localization to endoplasmic reticulum (GO:0070972)3.01367244
69positive regulation of macrophage differentiation (GO:0045651)3.00185570
70positive regulation of granulocyte differentiation (GO:0030854)3.00107572
71regulation of gamma-delta T cell differentiation (GO:0045586)2.99189054
72metallo-sulfur cluster assembly (GO:0031163)2.99044856
73iron-sulfur cluster assembly (GO:0016226)2.99044856
74purine-containing compound salvage (GO:0043101)2.98416489
75cellular metabolic compound salvage (GO:0043094)2.96929945
76negative regulation of mRNA processing (GO:0050686)2.94868040
77erythrocyte maturation (GO:0043249)2.93262602
78antigen processing and presentation via MHC class Ib (GO:0002475)2.92986928
79glucose 6-phosphate metabolic process (GO:0051156)2.92398334
80cellular protein complex disassembly (GO:0043624)2.91486611
81pyrimidine nucleotide catabolic process (GO:0006244)2.90924588
82positive regulation of T cell apoptotic process (GO:0070234)2.88467178
83regulation of B cell differentiation (GO:0045577)2.86931338
84ncRNA 3-end processing (GO:0043628)2.86706895
85ribosomal small subunit biogenesis (GO:0042274)2.85671995
86regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.85572988
87regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.85572988
88translational initiation (GO:0006413)2.84975724
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.84790167
90termination of RNA polymerase III transcription (GO:0006386)2.84790167
91positive regulation of triglyceride biosynthetic process (GO:0010867)2.84078203
92cytochrome complex assembly (GO:0017004)2.82574688
93DNA strand elongation involved in DNA replication (GO:0006271)2.82076128
94peptidyl-histidine modification (GO:0018202)2.81511879
95oxaloacetate metabolic process (GO:0006107)2.79452328
96telomere maintenance via semi-conservative replication (GO:0032201)2.78978543
97secretory granule organization (GO:0033363)2.78969381
98pseudouridine synthesis (GO:0001522)2.78480080
99snRNA transcription (GO:0009301)2.78337937
100regulation of skeletal muscle contraction (GO:0014819)2.77753611
101viral life cycle (GO:0019058)2.77637111
102T cell selection (GO:0045058)2.75802921
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75380457
104DNA strand elongation (GO:0022616)2.73530867
105lipoxygenase pathway (GO:0019372)2.72846001
106leukocyte apoptotic process (GO:0071887)2.71429435
107negative regulation of erythrocyte differentiation (GO:0045647)2.70420249
108regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.67332127
109guanosine-containing compound biosynthetic process (GO:1901070)2.66654760
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66134535
111viral mRNA export from host cell nucleus (GO:0046784)2.65805392
112methionine biosynthetic process (GO:0009086)2.65012888
113apoptotic process involved in morphogenesis (GO:0060561)2.63952982
114spliceosomal snRNP assembly (GO:0000387)2.63516069
115programmed necrotic cell death (GO:0097300)2.63502702
116regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63089737
117protein complex disassembly (GO:0043241)2.63029956
118negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62959674
119regulation of translation in response to stress (GO:0043555)2.62958716
120NIK/NF-kappaB signaling (GO:0038061)2.62676789
121negative regulation of translational initiation (GO:0045947)2.60685044
122purine nucleotide salvage (GO:0032261)2.59619436
123tricarboxylic acid metabolic process (GO:0072350)2.59205290
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59071525
125negative regulation of cell killing (GO:0031342)2.59071525
126mitotic G1/S transition checkpoint (GO:0044819)2.58840289
127positive regulation of lymphocyte apoptotic process (GO:0070230)2.58402387
128positive regulation of signal transduction by p53 class mediator (GO:1901798)2.58072064
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56523206
130* translation (GO:0006412)2.55849023
131regulation of superoxide anion generation (GO:0032928)2.55838341
132negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.55732047
133positive regulation of actin cytoskeleton reorganization (GO:2000251)2.55405353
134regulation of gamma-delta T cell activation (GO:0046643)2.54896810
135rRNA methylation (GO:0031167)2.52335282
136UTP biosynthetic process (GO:0006228)2.52047301
137mannose metabolic process (GO:0006013)2.50637036
138cellular response to interferon-beta (GO:0035458)2.50162952
139macromolecular complex disassembly (GO:0032984)2.49223252
140response to misfolded protein (GO:0051788)2.48791469
141pigment biosynthetic process (GO:0046148)2.48098946
142B cell receptor signaling pathway (GO:0050853)2.48049415
143chaperone-mediated protein transport (GO:0072321)2.47121746
144deoxyribonucleotide catabolic process (GO:0009264)2.46595376
145L-serine metabolic process (GO:0006563)2.45726087
146negative regulation of ligase activity (GO:0051352)2.44914477
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44914477
148negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.44886246
149pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.43104493
150tetrapyrrole metabolic process (GO:0033013)2.43075398
151folic acid metabolic process (GO:0046655)2.43071418
152histone H2A acetylation (GO:0043968)2.42721187
153neutrophil activation involved in immune response (GO:0002283)2.42325115
154regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)2.42309923
155negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.41163919
156nucleoside transmembrane transport (GO:1901642)2.40310626
157mitotic recombination (GO:0006312)2.39957738
158protein maturation by protein folding (GO:0022417)2.38486432
159GTP biosynthetic process (GO:0006183)2.35691961
160mitotic G1 DNA damage checkpoint (GO:0031571)2.35664742
161positive regulation of Cdc42 GTPase activity (GO:0043089)2.35159677
162purine ribonucleotide transport (GO:0015868)2.33624439
163amyloid precursor protein catabolic process (GO:0042987)2.33598299
164base-excision repair, AP site formation (GO:0006285)2.32556935
165deoxyribose phosphate catabolic process (GO:0046386)2.32294185
166mitochondrial calcium ion transport (GO:0006851)2.31641173
167mitochondrial fusion (GO:0008053)2.31163217
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30494620
169tumor necrosis factor-mediated signaling pathway (GO:0033209)2.29419960
170negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.28415010
171autophagic vacuole fusion (GO:0000046)2.26965332
172regulation of translational termination (GO:0006449)2.26903050
173cellular response to virus (GO:0098586)2.26797978
174response to food (GO:0032094)2.25640970
175positive thymic T cell selection (GO:0045059)2.25422681
176production of molecular mediator involved in inflammatory response (GO:0002532)2.24916957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90189008
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50107893
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83617045
4E2F7_22180533_ChIP-Seq_HELA_Human2.67582788
5MYC_22102868_ChIP-Seq_BL_Human2.56806315
6* ETS1_20019798_ChIP-Seq_JURKAT_Human2.42484966
7VDR_21846776_ChIP-Seq_THP-1_Human2.38843218
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.31908228
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29728895
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27848772
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.14938658
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13966518
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13754624
14CIITA_25753668_ChIP-Seq_RAJI_Human2.11568407
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.10128609
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08071136
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02781982
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01893083
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97643700
20* XRN2_22483619_ChIP-Seq_HELA_Human1.90977296
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86165589
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84875406
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83874829
24SCL_19346495_ChIP-Seq_HPC-7_Human1.82692932
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82250792
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81395437
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79877130
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.76785479
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72902433
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71249022
31LXR_22292898_ChIP-Seq_THP-1_Human1.70856764
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70389556
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66516574
34GATA1_22025678_ChIP-Seq_K562_Human1.63850147
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63763619
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62593160
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61773484
38* GABP_19822575_ChIP-Seq_HepG2_Human1.60380286
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.59990125
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57531391
41UTX_26944678_Chip-Seq_JUKART_Human1.56781592
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55284645
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54346829
44FOXP3_21729870_ChIP-Seq_TREG_Human1.53625889
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52431249
46KDM2B_26808549_Chip-Seq_DND41_Human1.51841831
47* VDR_23849224_ChIP-Seq_CD4+_Human1.51611289
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48438320
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.47542213
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47011377
51BCL6_27268052_Chip-Seq_Bcells_Human1.46594826
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.46259801
53DCP1A_22483619_ChIP-Seq_HELA_Human1.45803544
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.44407147
55P68_20966046_ChIP-Seq_HELA_Human1.44307152
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44085114
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43032653
58MAF_26560356_Chip-Seq_TH2_Human1.42919072
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42502149
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41775578
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.40858823
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40652750
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39996695
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37572207
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37515029
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37275131
67* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36445707
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.36276572
69* SMC4_20622854_ChIP-Seq_HELA_Human1.36213877
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33086470
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32903804
72* MAF_26560356_Chip-Seq_TH1_Human1.32667336
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.32451494
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30952099
75KDM5A_27292631_Chip-Seq_BREAST_Human1.30936452
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30218027
77NCOR1_26117541_ChIP-Seq_K562_Human1.29706141
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29655695
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29265032
80* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27606023
81* BCOR_27268052_Chip-Seq_Bcells_Human1.27404441
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26630530
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26252692
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23205672
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23048511
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22826535
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.22809759
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22487180
89* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19328881
90* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18122177
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18059252
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17779810
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17284229
94TCF7_22412390_ChIP-Seq_EML_Mouse1.17099224
95PHF8_20622854_ChIP-Seq_HELA_Human1.17002371
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16788509
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16494773
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.16367800
99CTCF_21964334_Chip-Seq_Bcells_Human1.16225466
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15891202
101SPI1_23547873_ChIP-Seq_NB4_Human1.15712769
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15503776
103* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15248804
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15228172
105VDR_24763502_ChIP-Seq_THP-1_Human1.15211405
106E2F1_20622854_ChIP-Seq_HELA_Human1.14225864
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13685921
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13574883
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13480121
110* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12640578
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11626952
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.11576087
113SA1_27219007_Chip-Seq_Bcells_Human1.10803023
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.09657078
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08724807
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08586395
117TTF2_22483619_ChIP-Seq_HELA_Human1.08529230
118TFEB_21752829_ChIP-Seq_HELA_Human1.08292818
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07961534
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07517923
121ZNF263_19887448_ChIP-Seq_K562_Human1.07245850
122* RACK7_27058665_Chip-Seq_MCF-7_Human1.07234601
123FOXP1_21924763_ChIP-Seq_HESCs_Human1.07120863
124MYB_26560356_Chip-Seq_TH1_Human1.07060010
125ETS1_21867929_ChIP-Seq_TH2_Mouse1.07058300
126CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07016280
127DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06997716
128CREB1_26743006_Chip-Seq_LNCaP_Human1.06194979
129ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05950535
130KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05344869
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.03472600
132CTCF_20526341_ChIP-Seq_ESCs_Human1.03197287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.42009612
2MP0004147_increased_porphyrin_level4.26774249
3MP0005451_abnormal_body_composition4.18793305
4MP0005058_abnormal_lysosome_morphology2.90689885
5MP0002396_abnormal_hematopoietic_system2.70977228
6MP0004185_abnormal_adipocyte_glucose2.44824150
7MP0009840_abnormal_foam_cell2.44093185
8MP0001661_extended_life_span2.38612185
9MP0000685_abnormal_immune_system2.30952018
10MP0009333_abnormal_splenocyte_physiolog2.28041015
11MP0003806_abnormal_nucleotide_metabolis2.27182276
12MP0002132_abnormal_respiratory_system2.21513173
13MP0008260_abnormal_autophagy2.19963012
14MP0003693_abnormal_embryo_hatching2.17207502
15MP0003763_abnormal_thymus_physiology2.08918645
16MP0006036_abnormal_mitochondrial_physio2.07350207
17MP0005671_abnormal_response_to2.05896459
18MP0008058_abnormal_DNA_repair2.03383643
19MP0005075_abnormal_melanosome_morpholog1.99843863
20MP0003111_abnormal_nucleus_morphology1.95091743
21MP0004043_abnormal_pH_regulation1.90693013
22MP0002398_abnormal_bone_marrow1.88110562
23MP0000749_muscle_degeneration1.85192190
24MP0002722_abnormal_immune_system1.84267536
25MP0005083_abnormal_biliary_tract1.84050654
26MP0003191_abnormal_cellular_cholesterol1.82168391
27MP0000689_abnormal_spleen_morphology1.75480801
28MP0004381_abnormal_hair_follicle1.72086417
29MP0000703_abnormal_thymus_morphology1.71447402
30MP0002148_abnormal_hypersensitivity_rea1.69198532
31MP0000678_abnormal_parathyroid_gland1.67386375
32MP0005360_urolithiasis1.66431877
33MP0004145_abnormal_muscle_electrophysio1.65820396
34MP0010155_abnormal_intestine_physiology1.62884971
35MP0005501_abnormal_skin_physiology1.62403158
36MP0002269_muscular_atrophy1.59871045
37MP0009278_abnormal_bone_marrow1.58710066
38MP0008007_abnormal_cellular_replicative1.58619041
39MP0001800_abnormal_humoral_immune1.57754995
40MP0004142_abnormal_muscle_tone1.57575007
41MP0003646_muscle_fatigue1.57353573
42MP0002429_abnormal_blood_cell1.55811960
43MP0000747_muscle_weakness1.54321211
44MP0010234_abnormal_vibrissa_follicle1.51233664
45MP0003172_abnormal_lysosome_physiology1.48445502
46MP0004957_abnormal_blastocyst_morpholog1.48050916
47MP0002419_abnormal_innate_immunity1.44235608
48MP0000858_altered_metastatic_potential1.43325273
49MP0000716_abnormal_immune_system1.38543560
50MP0001545_abnormal_hematopoietic_system1.37357220
51MP0005397_hematopoietic_system_phenotyp1.37357220
52MP0001873_stomach_inflammation1.36270899
53MP0002420_abnormal_adaptive_immunity1.35379173
54MP0003303_peritoneal_inflammation1.35210072
55MP0001845_abnormal_inflammatory_respons1.32185100
56MP0001819_abnormal_immune_cell1.32175868
57MP0004858_abnormal_nervous_system1.31334054
58MP0002970_abnormal_white_adipose1.30886733
59MP0003137_abnormal_impulse_conducting1.30521434
60MP0005220_abnormal_exocrine_pancreas1.28297213
61MP0001533_abnormal_skeleton_physiology1.28276292
62MP0003077_abnormal_cell_cycle1.28147907
63MP0001764_abnormal_homeostasis1.28084907
64MP0005310_abnormal_salivary_gland1.27868892
65MP0005330_cardiomyopathy1.24407192
66MP0010094_abnormal_chromosome_stability1.24321783
67MP0001986_abnormal_taste_sensitivity1.24318317
68MP0002723_abnormal_immune_serum1.23801531
69MP0003866_abnormal_defecation1.19732050
70MP0000759_abnormal_skeletal_muscle1.19395244
71MP0005365_abnormal_bile_salt1.18171468
72MP0003436_decreased_susceptibility_to1.17488524
73MP0006035_abnormal_mitochondrial_morpho1.17054447
74MP0005636_abnormal_mineral_homeostasis1.14937220
75MP0002796_impaired_skin_barrier1.14726184
76MP0005410_abnormal_fertilization1.11444171
77MP0000750_abnormal_muscle_regeneration1.10795183
78MP0001790_abnormal_immune_system1.10774722
79MP0005387_immune_system_phenotype1.10774722
80MP0000751_myopathy1.10532685
81MP0004264_abnormal_extraembryonic_tissu1.10299104
82MP0009785_altered_susceptibility_to1.08135605
83MP0004947_skin_inflammation1.07373098
84MP0002452_abnormal_antigen_presenting1.05995472
85MP0001348_abnormal_lacrimal_gland1.05789367
86MP0003879_abnormal_hair_cell1.05687491
87MP0005025_abnormal_response_to1.04735498
88MP0003011_delayed_dark_adaptation1.03977423
89MP0003705_abnormal_hypodermis_morpholog1.03669387
90MP0002277_abnormal_respiratory_mucosa1.03559545
91MP0005000_abnormal_immune_tolerance1.02120674
92MP0004084_abnormal_cardiac_muscle1.01570380
93MP0010329_abnormal_lipoprotein_level1.01555626
94MP0005666_abnormal_adipose_tissue1.00963362
95MP0005464_abnormal_platelet_physiology1.00382997
96MP0003724_increased_susceptibility_to0.99940137
97MP0002019_abnormal_tumor_incidence0.99808382
98MP0002089_abnormal_postnatal_growth/wei0.99675163
99MP0003453_abnormal_keratinocyte_physiol0.98380465
100MP0000313_abnormal_cell_death0.97714419
101MP0006054_spinal_hemorrhage0.97404668
102MP0002106_abnormal_muscle_physiology0.97183447
103MP0009931_abnormal_skin_appearance0.95816276
104MP0009643_abnormal_urine_homeostasis0.95383216
105MP0004215_abnormal_myocardial_fiber0.93682003
106MP0000003_abnormal_adipose_tissue0.92604197
107MP0001216_abnormal_epidermal_layer0.92079922
108MP0004087_abnormal_muscle_fiber0.90938577
109MP0001849_ear_inflammation0.89701382
110MP0009764_decreased_sensitivity_to0.89650417
111MP0000609_abnormal_liver_physiology0.89491657
112MP0000598_abnormal_liver_morphology0.89245173
113MP0004233_abnormal_muscle_weight0.89228326
114MP0003315_abnormal_perineum_morphology0.88988131
115MP0005551_abnormal_eye_electrophysiolog0.88330874
116MP0005076_abnormal_cell_differentiation0.87887080
117MP0000358_abnormal_cell_content/0.86809388
118MP0008569_lethality_at_weaning0.86503936
119MP0001727_abnormal_embryo_implantation0.85684584
120MP0002166_altered_tumor_susceptibility0.85215967
121MP0005584_abnormal_enzyme/coenzyme_acti0.84909675
122MP0005670_abnormal_white_adipose0.84795543
123MP0005375_adipose_tissue_phenotype0.84679413
124MP0001835_abnormal_antigen_presentation0.84607079
125MP0002638_abnormal_pupillary_reflex0.84235257
126MP0002405_respiratory_system_inflammati0.83881526
127MP0010630_abnormal_cardiac_muscle0.82656911
128MP0000490_abnormal_crypts_of0.82374510
129MP0005332_abnormal_amino_acid0.82299871
130MP0005369_muscle_phenotype0.81501259
131MP0002822_catalepsy0.80887339
132MP0004130_abnormal_muscle_cell0.80676349
133MP0001730_embryonic_growth_arrest0.78433835
134MP0005319_abnormal_enzyme/_coenzyme0.77117544
135MP0002139_abnormal_hepatobiliary_system0.76482482
136MP0000681_abnormal_thyroid_gland0.75523434
137MP0001919_abnormal_reproductive_system0.75261226
138MP0008469_abnormal_protein_level0.74631319
139MP0004036_abnormal_muscle_relaxation0.74309901
140MP0001756_abnormal_urination0.74024947
141MP0006138_congestive_heart_failure0.73497107
142MP0009763_increased_sensitivity_to0.73253652
143MP0004782_abnormal_surfactant_physiolog0.72612642
144MP0000470_abnormal_stomach_morphology0.72561549
145MP0001663_abnormal_digestive_system0.72018635
146MP0003786_premature_aging0.69998779

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.58175174
2Abnormal number of erythroid precursors (HP:0012131)4.30877668
3Abnormality of cells of the erythroid lineage (HP:0012130)3.92928477
4Petechiae (HP:0000967)3.25108433
5Myopathic facies (HP:0002058)3.25011013
6Microretrognathia (HP:0000308)3.03631660
7Panhypogammaglobulinemia (HP:0003139)3.00961339
8Congenital stationary night blindness (HP:0007642)2.99954932
9Chronic obstructive pulmonary disease (HP:0006510)2.91271315
10Obstructive lung disease (HP:0006536)2.91271315
11Aplastic anemia (HP:0001915)2.88887436
12Eczematoid dermatitis (HP:0000976)2.87534986
13Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86422772
14Prolonged neonatal jaundice (HP:0006579)2.85377069
15Hypertensive crisis (HP:0100735)2.84576923
16Cerebral hypomyelination (HP:0006808)2.81266379
17Hepatic necrosis (HP:0002605)2.80740253
18Increased serum ferritin (HP:0003281)2.76751309
19Reticulocytopenia (HP:0001896)2.71011880
20Poikilocytosis (HP:0004447)2.70471414
21Progressive muscle weakness (HP:0003323)2.69996363
22Hepatocellular necrosis (HP:0001404)2.66965544
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.65563353
24Macrocytic anemia (HP:0001972)2.61884105
25Abnormality of reticulocytes (HP:0004312)2.61710256
26Ragged-red muscle fibers (HP:0003200)2.59337085
27Reticulocytosis (HP:0001923)2.56478092
28Truncus arteriosus (HP:0001660)2.56009712
29Broad face (HP:0000283)2.55693880
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53900295
31Rough bone trabeculation (HP:0100670)2.53349925
32Hypoglycemic coma (HP:0001325)2.51744061
33Premature ovarian failure (HP:0008209)2.51524772
34Cholelithiasis (HP:0001081)2.51367469
35IgM deficiency (HP:0002850)2.51098826
36Increased cerebral lipofuscin (HP:0011813)2.46376584
37Stridor (HP:0010307)2.46298276
38Recurrent bacterial skin infections (HP:0005406)2.44820289
39Abnormality of iron homeostasis (HP:0011031)2.44656707
40Abnormal rod and cone electroretinograms (HP:0008323)2.44027654
41Pallor (HP:0000980)2.43200575
42Hyperthyroidism (HP:0000836)2.42176944
43Granulocytopenia (HP:0001913)2.40499734
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37727388
453-Methylglutaconic aciduria (HP:0003535)2.37021474
46Concave nail (HP:0001598)2.36943941
47Abnormal gallbladder morphology (HP:0012437)2.36497218
48Pustule (HP:0200039)2.36405790
49Recurrent abscess formation (HP:0002722)2.36097224
50Muscle fiber inclusion bodies (HP:0100299)2.34805680
51Gastrointestinal infarctions (HP:0005244)2.33941284
52Paralysis (HP:0003470)2.32800809
53Opisthotonus (HP:0002179)2.31462621
54Increased serum lactate (HP:0002151)2.29753246
55Abnormality of transition element cation homeostasis (HP:0011030)2.28677387
56Abnormality of macrophages (HP:0004311)2.26809195
57Nemaline bodies (HP:0003798)2.26701488
58Hyperbilirubinemia (HP:0002904)2.24400553
59Abnormality of the pancreatic islet cells (HP:0006476)2.22139659
60Abnormality of endocrine pancreas physiology (HP:0012093)2.22139659
61Abnormality of fatty-acid metabolism (HP:0004359)2.21247982
62Increased muscle lipid content (HP:0009058)2.18941896
63Bulbar palsy (HP:0001283)2.18698256
64Annular pancreas (HP:0001734)2.18535728
65Severe combined immunodeficiency (HP:0004430)2.17449876
66Nonimmune hydrops fetalis (HP:0001790)2.16555861
67Abnormality of nail color (HP:0100643)2.15876115
68Increased intramyocellular lipid droplets (HP:0012240)2.13548892
69Combined immunodeficiency (HP:0005387)2.13433100
70Myositis (HP:0100614)2.13227423
71Mediastinal lymphadenopathy (HP:0100721)2.13226594
72Cerebral palsy (HP:0100021)2.12648767
73Increased IgE level (HP:0003212)2.12165987
74Microvesicular hepatic steatosis (HP:0001414)2.11172651
75Myoglobinuria (HP:0002913)2.10658646
76Exercise-induced myalgia (HP:0003738)2.10256346
77Recurrent viral infections (HP:0004429)2.09743284
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08008329
79Meningitis (HP:0001287)2.06969674
80Personality changes (HP:0000751)2.06464997
81Achilles tendon contracture (HP:0001771)2.05950160
82Abnormality of glycolipid metabolism (HP:0010969)2.05038153
83Abnormality of liposaccharide metabolism (HP:0010968)2.05038153
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.05038153
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.03042005
86Hyperinsulinemic hypoglycemia (HP:0000825)2.02173435
87Agammaglobulinemia (HP:0004432)2.02170106
88Rhabdomyolysis (HP:0003201)2.02025924
89Gastrointestinal inflammation (HP:0004386)2.00307391
90Neutropenia (HP:0001875)2.00238664
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99388429
92Dicarboxylic aciduria (HP:0003215)1.99388429
93Abnormal trabecular bone morphology (HP:0100671)1.99034085
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.98542743
95Calcaneovalgus deformity (HP:0001848)1.96940404
96Chronic otitis media (HP:0000389)1.95569184
97Abnormal hair laboratory examination (HP:0003328)1.94806532
98Hyperlipoproteinemia (HP:0010980)1.94029521
99Generalized hyperpigmentation (HP:0007440)1.93800146
100Hyperacusis (HP:0010780)1.93359655
101Gastrointestinal dysmotility (HP:0002579)1.93314987
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.92674623
103Ileus (HP:0002595)1.92586743
104Abnormality of the Achilles tendon (HP:0005109)1.92571208
105Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92369300
106Septate vagina (HP:0001153)1.91353212
107Colitis (HP:0002583)1.91109127
108Trismus (HP:0000211)1.90183018
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88977015
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88977015
111Emotional lability (HP:0000712)1.86663978
112Encephalitis (HP:0002383)1.86636440
113Albinism (HP:0001022)1.86180938
114Dysostosis multiplex (HP:0000943)1.85987814
115Cortical visual impairment (HP:0100704)1.85794949
116Lactic acidosis (HP:0003128)1.85580115
117Elevated erythrocyte sedimentation rate (HP:0003565)1.84806656
118Abnormality of T cell physiology (HP:0011840)1.84457784
119Hemorrhage of the eye (HP:0011885)1.83842412
120Acute hepatic failure (HP:0006554)1.82986865
121Purpura (HP:0000979)1.82954715
122Recurrent fungal infections (HP:0002841)1.82163561
123Epistaxis (HP:0000421)1.81866382
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80914191
125Ketoacidosis (HP:0001993)1.80587982
126Ketosis (HP:0001946)1.80176079
127Erythema (HP:0010783)1.79951041
128Ventricular tachycardia (HP:0004756)1.78985049
129Oral leukoplakia (HP:0002745)1.77853214
130Orchitis (HP:0100796)1.77795102
131Pancreatic islet-cell hyperplasia (HP:0004510)1.77677035
132Abnormality of T cells (HP:0002843)1.77150690
133Seborrheic dermatitis (HP:0001051)1.76937398
134Thrombocytosis (HP:0001894)1.76751341
135Recurrent skin infections (HP:0001581)1.76529143
136Pancytopenia (HP:0001876)1.76089645
137Squamous cell carcinoma (HP:0002860)1.75995673
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75456652
139Short femoral neck (HP:0100864)1.75281411
140Gastrointestinal stroma tumor (HP:0100723)1.75041824
141Testicular atrophy (HP:0000029)1.74329372
142Areflexia of lower limbs (HP:0002522)1.73688739
143Megaloblastic anemia (HP:0001889)1.73426340
144Recurrent cutaneous fungal infections (HP:0011370)1.73356765
145Chronic mucocutaneous candidiasis (HP:0002728)1.73356765
146Abnormal blistering of the skin (HP:0008066)1.73230458
147Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73116037
148Mitochondrial inheritance (HP:0001427)1.72474677
149Prolonged bleeding time (HP:0003010)1.72347979
150Hypochromic anemia (HP:0001931)1.71205739
151Abnormality of eosinophils (HP:0001879)1.70902362
152Inflammation of the large intestine (HP:0002037)1.70900300
153Hypoparathyroidism (HP:0000829)1.70810131
154Progressive neurologic deterioration (HP:0002344)1.70352944
155Secondary amenorrhea (HP:0000869)1.69777716
156Cholecystitis (HP:0001082)1.69267079
157Abnormal gallbladder physiology (HP:0012438)1.69267079
158Urticaria (HP:0001025)1.67849418
159Hypercortisolism (HP:0001578)1.66534129
160Papilloma (HP:0012740)1.65812047
161Verrucae (HP:0200043)1.65812047
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65715111
163Nail dystrophy (HP:0008404)1.65364991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.95844379
2RIPK15.47515212
3SMG13.04610019
4ERN12.91292069
5IRAK32.86609092
6MAP4K12.85062044
7STK162.68773819
8NEK12.45065861
9NME22.27615121
10BLK2.25200388
11KDR2.20247834
12TLK12.15564965
13TSSK62.15438753
14PIM21.98947689
15BCKDK1.97407500
16CAMKK21.94758862
17CDK191.88777920
18BUB11.86950900
19TESK21.85813289
20CAMK1D1.81504591
21EEF2K1.80968198
22SIK31.70758349
23INSRR1.69454192
24VRK21.67542084
25EIF2AK31.61413864
26IRAK41.53102691
27MAP3K101.49333094
28TRIB31.47709584
29MAPK151.46731315
30TBK11.43171432
31TNIK1.42915720
32NEK21.38068333
33MAP3K111.36751612
34TESK11.34490997
35BMPR21.33364985
36CAMK1G1.32384693
37TEC1.26138202
38SRPK11.18024349
39CDK121.11845793
40SIK11.11672014
41PINK11.10077200
42PRPF4B1.09608530
43TNK21.09529539
44MUSK1.08587826
45MAPK111.08057018
46RPS6KA41.07986138
47GRK11.07617250
48ZAP701.07392726
49SIK21.04613057
50BTK1.02022694
51SYK0.99230835
52TYK20.96256999
53ILK0.96134180
54PRKD20.95264987
55CCNB10.94914381
56BRSK10.94133116
57TAOK20.93058882
58PTK60.92977759
59IRAK20.92677674
60PKN20.92306271
61CAMK10.90589008
62FGFR40.89739090
63DYRK1B0.87426793
64MAP3K70.84869529
65BMX0.83218845
66FLT30.82273186
67MAP3K10.80593493
68TAOK30.78246304
69LIMK10.78208599
70BRAF0.77315802
71MAP3K30.76787300
72CDK40.75726835
73PIK3CG0.74441883
74IKBKE0.74043695
75CAMK40.73713993
76NME10.73388649
77VRK10.71956554
78GRK60.71873193
79TAOK10.71099450
80JAK30.70418299
81EIF2AK10.70149922
82CSK0.69713336
83WEE10.69448738
84TTN0.68097983
85ITK0.66104448
86ZAK0.66065128
87DYRK30.65451564
88MAPKAPK30.65018519
89ICK0.64564773
90MARK20.63448478
91* PDPK10.62519591
92OBSCN0.61185601
93DAPK10.60717955
94RAF10.59079572
95AKT20.57923468
96BRSK20.57594270
97MAP3K80.57571426
98ARAF0.57552796
99DAPK30.55512181
100CDK80.54306921
101HIPK20.54228125
102AURKA0.52776686
103RPS6KL10.52465971
104RPS6KC10.52465971
105* PRKCI0.52221151
106MAPK120.52035181
107TXK0.50053525
108RPS6KA50.49249747
109PAK40.47602720
110RPS6KA60.47218985
111KIT0.46887482
112PDK10.46763648
113LYN0.45908459
114CAMKK10.45903365
115MARK30.45775351
116EPHB10.44796709
117STK40.42332016
118MAP2K60.42167396
119MAPKAPK20.41851345
120RPS6KA20.41577199
121RPS6KB20.41404051
122HCK0.41051976
123PIM10.37865429
124CSF1R0.37363245
125MAP3K140.36090902
126ATR0.34773184
127ABL20.33725852
128MST1R0.33717477
129EPHA20.33701903
130PAK10.33494278
131MAPK70.32433965
132MAP2K30.32342754
133PRKG20.31480219
134IKBKB0.31011960
135MAP3K130.30756055
136MAP2K20.29518804
137LRRK20.29329380
138FES0.28830178
139STK380.28658733
140* MTOR0.26644574
141LCK0.26445992
142RIPK40.25944920
143CDK70.25497645
144CDC42BPA0.24779688

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.60822239
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.23375414
3DNA replication_Homo sapiens_hsa030303.15610799
4Proteasome_Homo sapiens_hsa030503.03879611
5Primary immunodeficiency_Homo sapiens_hsa053402.94096577
6Mismatch repair_Homo sapiens_hsa034302.86343942
7RNA polymerase_Homo sapiens_hsa030202.84435755
8Sulfur relay system_Homo sapiens_hsa041222.72203330
9Folate biosynthesis_Homo sapiens_hsa007902.71385128
10Spliceosome_Homo sapiens_hsa030402.69341218
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.56863687
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.55789139
13Tyrosine metabolism_Homo sapiens_hsa003502.25196721
14Pyrimidine metabolism_Homo sapiens_hsa002402.16542310
15Base excision repair_Homo sapiens_hsa034102.05426831
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.03718834
17Pentose phosphate pathway_Homo sapiens_hsa000301.99712176
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.94359552
19Biosynthesis of amino acids_Homo sapiens_hsa012301.88440388
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86102924
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63951820
22Homologous recombination_Homo sapiens_hsa034401.60710608
23Phototransduction_Homo sapiens_hsa047441.59551706
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53144697
25Nucleotide excision repair_Homo sapiens_hsa034201.52978349
26Fructose and mannose metabolism_Homo sapiens_hsa000511.52860435
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50645994
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42979182
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.42717952
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40828327
31Purine metabolism_Homo sapiens_hsa002301.38254039
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36897888
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34904181
34Carbon metabolism_Homo sapiens_hsa012001.30109433
35Regulation of autophagy_Homo sapiens_hsa041401.27372760
36Graft-versus-host disease_Homo sapiens_hsa053321.26918220
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.25057339
38Non-homologous end-joining_Homo sapiens_hsa034501.24775209
39Other glycan degradation_Homo sapiens_hsa005111.21575134
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.21496570
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17632896
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17401888
43N-Glycan biosynthesis_Homo sapiens_hsa005101.16147565
44VEGF signaling pathway_Homo sapiens_hsa043701.14924628
45Caffeine metabolism_Homo sapiens_hsa002321.14732590
46ABC transporters_Homo sapiens_hsa020101.14086086
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13901177
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11108816
49Non-small cell lung cancer_Homo sapiens_hsa052231.09945334
50Hepatitis C_Homo sapiens_hsa051601.07777222
51Vitamin B6 metabolism_Homo sapiens_hsa007501.06609228
52TNF signaling pathway_Homo sapiens_hsa046681.04431302
53Systemic lupus erythematosus_Homo sapiens_hsa053221.01884588
54Osteoclast differentiation_Homo sapiens_hsa043800.99802734
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97359224
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.96883766
57RNA transport_Homo sapiens_hsa030130.96648376
58B cell receptor signaling pathway_Homo sapiens_hsa046620.94923948
59Fanconi anemia pathway_Homo sapiens_hsa034600.94694221
60Oxidative phosphorylation_Homo sapiens_hsa001900.93485507
61Leishmaniasis_Homo sapiens_hsa051400.92600760
62Epstein-Barr virus infection_Homo sapiens_hsa051690.91235287
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.91068954
64Herpes simplex infection_Homo sapiens_hsa051680.88907371
65Glutathione metabolism_Homo sapiens_hsa004800.88547187
66Tuberculosis_Homo sapiens_hsa051520.88275288
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87723379
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.86692174
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86063355
70Antigen processing and presentation_Homo sapiens_hsa046120.85814916
71Viral carcinogenesis_Homo sapiens_hsa052030.84690455
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80043743
73Chronic myeloid leukemia_Homo sapiens_hsa052200.79347783
74Parkinsons disease_Homo sapiens_hsa050120.77516648
75Cell cycle_Homo sapiens_hsa041100.76824273
76Fatty acid elongation_Homo sapiens_hsa000620.75484319
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.74872893
78Cardiac muscle contraction_Homo sapiens_hsa042600.74146887
79Allograft rejection_Homo sapiens_hsa053300.67952706
80Selenocompound metabolism_Homo sapiens_hsa004500.67926631
81Hepatitis B_Homo sapiens_hsa051610.66842609
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.65946237
83Hematopoietic cell lineage_Homo sapiens_hsa046400.65315564
84Lysine degradation_Homo sapiens_hsa003100.65300207
85Influenza A_Homo sapiens_hsa051640.63969119
86Pancreatic cancer_Homo sapiens_hsa052120.62219244
87Fatty acid metabolism_Homo sapiens_hsa012120.60981195
88One carbon pool by folate_Homo sapiens_hsa006700.58421639
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57889302
90Autoimmune thyroid disease_Homo sapiens_hsa053200.56629930
91Peroxisome_Homo sapiens_hsa041460.56579539
92* Insulin resistance_Homo sapiens_hsa049310.56214890
93Notch signaling pathway_Homo sapiens_hsa043300.54172290
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53943611
95RNA degradation_Homo sapiens_hsa030180.53894710
96Metabolic pathways_Homo sapiens_hsa011000.52392441
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51837538
98Arginine biosynthesis_Homo sapiens_hsa002200.51692566
99Sulfur metabolism_Homo sapiens_hsa009200.50593739
100Arginine and proline metabolism_Homo sapiens_hsa003300.50354495
101Galactose metabolism_Homo sapiens_hsa000520.49470614
102Pancreatic secretion_Homo sapiens_hsa049720.49205710
103Circadian rhythm_Homo sapiens_hsa047100.48907297
104* mTOR signaling pathway_Homo sapiens_hsa041500.48738740
105* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48182191
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48121229
107Protein export_Homo sapiens_hsa030600.47870845
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47842442
109beta-Alanine metabolism_Homo sapiens_hsa004100.45934154
110Toxoplasmosis_Homo sapiens_hsa051450.45852702
111Fatty acid biosynthesis_Homo sapiens_hsa000610.45242092
112* Insulin signaling pathway_Homo sapiens_hsa049100.44645992
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44159916
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43734229
115Alzheimers disease_Homo sapiens_hsa050100.43553289
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42870249
117p53 signaling pathway_Homo sapiens_hsa041150.42851815
118Thyroid cancer_Homo sapiens_hsa052160.42561152
119Fatty acid degradation_Homo sapiens_hsa000710.42385939
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.42000511
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41630750
122* Acute myeloid leukemia_Homo sapiens_hsa052210.41381818
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40498347
124Lysosome_Homo sapiens_hsa041420.39536665
125Pyruvate metabolism_Homo sapiens_hsa006200.39495141
126Shigellosis_Homo sapiens_hsa051310.36603424
127* AMPK signaling pathway_Homo sapiens_hsa041520.35580625
128Alcoholism_Homo sapiens_hsa050340.35316911
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34908382
130Endocytosis_Homo sapiens_hsa041440.34901520
131* ErbB signaling pathway_Homo sapiens_hsa040120.34412064
132Phenylalanine metabolism_Homo sapiens_hsa003600.33981374
133Measles_Homo sapiens_hsa051620.33973611
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.32641848
135Bile secretion_Homo sapiens_hsa049760.32608103
136* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32470214
137* HIF-1 signaling pathway_Homo sapiens_hsa040660.32029016
138T cell receptor signaling pathway_Homo sapiens_hsa046600.30539467
139HTLV-I infection_Homo sapiens_hsa051660.30123748
140Bladder cancer_Homo sapiens_hsa052190.29365982
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27062482
142Sphingolipid metabolism_Homo sapiens_hsa006000.26029035
143Apoptosis_Homo sapiens_hsa042100.23221972
144* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22922503
145Synaptic vesicle cycle_Homo sapiens_hsa047210.22835553
146mRNA surveillance pathway_Homo sapiens_hsa030150.20948544
147Rheumatoid arthritis_Homo sapiens_hsa053230.20751607

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