RPS6KA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.57295754
2plasma lipoprotein particle assembly (GO:0034377)5.29174599
3negative regulation of fibrinolysis (GO:0051918)5.22195677
4protein-lipid complex assembly (GO:0065005)4.98355681
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77575857
6regulation of protein activation cascade (GO:2000257)4.65885029
7regulation of complement activation (GO:0030449)4.61864732
8regulation of fibrinolysis (GO:0051917)4.56997523
9negative regulation of protein activation cascade (GO:2000258)4.53488088
10low-density lipoprotein particle remodeling (GO:0034374)4.47939117
11negative regulation of complement activation (GO:0045916)4.10403012
12peptidyl-glutamic acid carboxylation (GO:0017187)4.02906098
13protein carboxylation (GO:0018214)4.02906098
14intestinal cholesterol absorption (GO:0030299)3.96667054
15cholesterol efflux (GO:0033344)3.94501906
16plasma lipoprotein particle organization (GO:0071827)3.76583831
17regulation of apoptotic cell clearance (GO:2000425)3.71988528
18positive regulation of gamma-delta T cell activation (GO:0046645)3.71305494
19protein-lipid complex subunit organization (GO:0071825)3.69021438
20cytoplasmic mRNA processing body assembly (GO:0033962)3.66770574
21regulation of cholesterol homeostasis (GO:2000188)3.65795264
22growth hormone receptor signaling pathway (GO:0060396)3.57656704
23protein-lipid complex remodeling (GO:0034368)3.56347615
24macromolecular complex remodeling (GO:0034367)3.56347615
25plasma lipoprotein particle remodeling (GO:0034369)3.56347615
26negative regulation of humoral immune response (GO:0002921)3.54316879
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.53321951
28regulation of cholesterol esterification (GO:0010872)3.51666011
29positive regulation of histone deacetylation (GO:0031065)3.46063682
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43140441
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43140441
32regulation of gamma-delta T cell differentiation (GO:0045586)3.22939650
33complement activation, alternative pathway (GO:0006957)3.21669368
34detection of molecule of bacterial origin (GO:0032490)3.21475156
35intestinal absorption (GO:0050892)3.21238864
36pinocytosis (GO:0006907)3.20144049
37positive regulation of hemostasis (GO:1900048)3.18139120
38positive regulation of blood coagulation (GO:0030194)3.18139120
39positive regulation of extracellular matrix organization (GO:1903055)3.17830346
40plasma lipoprotein particle clearance (GO:0034381)3.17326551
41regulation of humoral immune response (GO:0002920)3.17005974
42embryonic process involved in female pregnancy (GO:0060136)3.16819971
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.14778851
44antigen processing and presentation of endogenous antigen (GO:0019883)3.13481628
45high-density lipoprotein particle remodeling (GO:0034375)3.10558240
46blood coagulation, intrinsic pathway (GO:0007597)3.07899008
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05407593
48negative regulation of cell killing (GO:0031342)3.05407593
49cellular response to growth hormone stimulus (GO:0071378)3.05179767
50regulation of extracellular matrix disassembly (GO:0010715)3.03664331
51cellular response to ethanol (GO:0071361)3.01492448
52regulation of gamma-delta T cell activation (GO:0046643)3.00285404
53lipoprotein metabolic process (GO:0042157)2.99581855
54positive regulation of coagulation (GO:0050820)2.98491002
55acute-phase response (GO:0006953)2.96061510
56protein localization to endosome (GO:0036010)2.95937178
57phospholipid efflux (GO:0033700)2.92447192
58positive regulation of natural killer cell differentiation (GO:0032825)2.90935664
59regulation of extracellular matrix organization (GO:1903053)2.87889884
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85608516
61reverse cholesterol transport (GO:0043691)2.83298184
62negative regulation of granulocyte differentiation (GO:0030853)2.78344160
63positive thymic T cell selection (GO:0045059)2.77041861
64regulation of bile acid biosynthetic process (GO:0070857)2.76750282
65tyrosine phosphorylation of STAT protein (GO:0007260)2.75200733
66mitotic sister chromatid cohesion (GO:0007064)2.74222788
67lipoprotein transport (GO:0042953)2.73543274
68low-density lipoprotein particle clearance (GO:0034383)2.72951946
69diacylglycerol metabolic process (GO:0046339)2.70946299
70substrate-dependent cell migration (GO:0006929)2.70097868
71positive regulation of macrophage cytokine production (GO:0060907)2.68800767
72positive regulation by symbiont of host defense response (GO:0052509)2.68678232
73modulation by symbiont of host defense response (GO:0052031)2.68678232
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68678232
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68678232
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.68678232
77modulation by symbiont of host immune response (GO:0052553)2.68678232
78COPII vesicle coating (GO:0048208)2.67653685
79negative regulation of cholesterol transport (GO:0032375)2.67439901
80negative regulation of sterol transport (GO:0032372)2.67439901
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.67272282
82regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66761379
83apoptotic cell clearance (GO:0043277)2.66243706
84oligosaccharide catabolic process (GO:0009313)2.65430946
85positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.64898030
86glucocorticoid receptor signaling pathway (GO:0042921)2.61295134
87cell adhesion mediated by integrin (GO:0033627)2.61056304
88definitive hemopoiesis (GO:0060216)2.60808436
89corticosteroid receptor signaling pathway (GO:0031958)2.60426910
90NLS-bearing protein import into nucleus (GO:0006607)2.56783638
91negative regulation of fatty acid transport (GO:2000192)2.56511594
92positive regulation of phagocytosis (GO:0050766)2.56103304
93vascular endothelial growth factor signaling pathway (GO:0038084)2.55642926
94positive regulation of steroid metabolic process (GO:0045940)2.54861321
95regulation of plasminogen activation (GO:0010755)2.54672193
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53901957
97insulin-like growth factor receptor signaling pathway (GO:0048009)2.53555412
98protein activation cascade (GO:0072376)2.53494382
99cortical actin cytoskeleton organization (GO:0030866)2.51808514
100cholesterol transport (GO:0030301)2.51192953
101sterol transport (GO:0015918)2.51192953
102germ cell migration (GO:0008354)2.50888264
103phospholipid homeostasis (GO:0055091)2.49839732
104regulation of macrophage cytokine production (GO:0010935)2.48481621
105positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47656540
106positive regulation of chemokine secretion (GO:0090197)2.47279877
107detection of external biotic stimulus (GO:0098581)2.46427987
108negative thymic T cell selection (GO:0045060)2.46311225
109thymic T cell selection (GO:0045061)2.44502343
110negative T cell selection (GO:0043383)2.43589968
111regulation of chemokine secretion (GO:0090196)2.43490632
112L-phenylalanine metabolic process (GO:0006558)2.42451015
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.42451015
114fibrinolysis (GO:0042730)2.41880820
115complement activation, classical pathway (GO:0006958)2.40868933
116positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40680971
117mannose metabolic process (GO:0006013)2.40443319
118regulation of cholesterol storage (GO:0010885)2.39017724
119negative regulation of hemostasis (GO:1900047)2.38922683
120negative regulation of blood coagulation (GO:0030195)2.38922683
121response to interleukin-15 (GO:0070672)2.36985730
122histone H3-K36 demethylation (GO:0070544)2.36882877
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.35622571
124L-phenylalanine catabolic process (GO:0006559)2.35622571
125establishment of endothelial barrier (GO:0061028)2.35468036
126positive regulation of transforming growth factor beta production (GO:0071636)2.33715589
127antigen processing and presentation via MHC class Ib (GO:0002475)2.32549958
128hepatocyte apoptotic process (GO:0097284)2.31823241
129dicarboxylic acid biosynthetic process (GO:0043650)2.31706822
130morphogenesis of an endothelium (GO:0003159)2.31309785
131endothelial tube morphogenesis (GO:0061154)2.31309785
132positive T cell selection (GO:0043368)2.30793560
133natural killer cell differentiation (GO:0001779)2.29436828
134negative regulation of phagocytosis (GO:0050765)2.27750519
135positive regulation of lamellipodium assembly (GO:0010592)2.25872827
136T cell selection (GO:0045058)2.25823114
137regulation of interferon-beta biosynthetic process (GO:0045357)2.25599921
138nerve growth factor signaling pathway (GO:0038180)2.25465729
139positive regulation of B cell differentiation (GO:0045579)2.25061588
140peptidyl-lysine dimethylation (GO:0018027)2.24325798
141positive regulation of protein deacetylation (GO:0090312)2.22841421
142leukocyte tethering or rolling (GO:0050901)2.22177395
143cell-substrate junction assembly (GO:0007044)2.21788350
144negative regulation of erythrocyte differentiation (GO:0045647)2.21294241
145angiogenesis involved in wound healing (GO:0060055)2.17586691
146regulation of B cell receptor signaling pathway (GO:0050855)2.17301608
147leukocyte cell-cell adhesion (GO:0007159)2.16950704
148stress fiber assembly (GO:0043149)2.15908656
149cellular response to interferon-alpha (GO:0035457)2.14319671
150hypotonic response (GO:0006971)2.13600210
151Arp2/3 complex-mediated actin nucleation (GO:0034314)2.13431225
152nuclear pore complex assembly (GO:0051292)2.13371372
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13117803
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12219256
155positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.10025017
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.09770490
157plasma membrane repair (GO:0001778)2.09267718
158regulation of T cell tolerance induction (GO:0002664)2.09267221
159leukocyte aggregation (GO:0070486)2.08672946
160regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.07980425
161cortical cytoskeleton organization (GO:0030865)2.07280000
162macrophage activation involved in immune response (GO:0002281)2.07113218
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.06526304
164hemidesmosome assembly (GO:0031581)2.06516347
165cellular response to zinc ion (GO:0071294)2.05423453
166positive regulation of interferon-alpha production (GO:0032727)2.05124517
167coronary vasculature morphogenesis (GO:0060977)2.04937051
168cellular extravasation (GO:0045123)2.04123168
169positive regulation of blood vessel endothelial cell migration (GO:0043536)2.00721591
170neuron projection extension involved in neuron projection guidance (GO:1902284)2.00712337
171axon extension involved in axon guidance (GO:0048846)2.00712337
172interferon-gamma production (GO:0032609)2.00410446
173regulation of interferon-alpha production (GO:0032647)1.99911831
174embryonic camera-type eye morphogenesis (GO:0048596)1.98338907
175positive regulation of p38MAPK cascade (GO:1900745)1.98295679
176response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.98054832
177response to host defenses (GO:0052200)1.98054832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.41969826
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.39623860
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.15507628
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.11367906
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.93404528
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.84689412
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81038785
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.72825265
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.71768075
10* FOXA2_19822575_ChIP-Seq_HepG2_Human2.65583201
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.62076061
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.57032421
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50986161
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48885113
15MYC_22102868_ChIP-Seq_BL_Human2.33433564
16RUNX_20019798_ChIP-Seq_JUKART_Human2.28564032
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19232915
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19116265
19E2F7_22180533_ChIP-Seq_HELA_Human2.17326122
20TCF7_22412390_ChIP-Seq_EML_Mouse2.16665018
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16218338
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12141974
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06575697
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.02666318
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94516469
26CLOCK_20551151_ChIP-Seq_293T_Human1.94010459
27KDM2B_26808549_Chip-Seq_DND41_Human1.88943282
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.87719336
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.87520431
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82775980
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81464602
32GATA1_22025678_ChIP-Seq_K562_Human1.80004385
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78745805
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76113187
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.72613216
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.72082817
37MAF_26560356_Chip-Seq_TH1_Human1.71000539
38MYB_26560356_Chip-Seq_TH2_Human1.70883708
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67471875
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64842591
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64722856
42* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63780144
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63659855
44SCL_19346495_ChIP-Seq_HPC-7_Human1.62848483
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.61948195
46VDR_21846776_ChIP-Seq_THP-1_Human1.61479058
47VDR_24763502_ChIP-Seq_THP-1_Human1.60633170
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60545824
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.58683393
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.58062899
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56303823
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55934386
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54690772
54SPI1_23127762_ChIP-Seq_K562_Human1.53760604
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.51773623
56UTX_26944678_Chip-Seq_JUKART_Human1.48515618
57* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47885745
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.46291010
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45293664
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43973985
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43298509
62VDR_24787735_ChIP-Seq_THP-1_Human1.41157297
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40439124
64MYB_26560356_Chip-Seq_TH1_Human1.39175397
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38489429
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.37939343
67* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37522694
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36610227
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36610227
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36248184
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35811802
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32927539
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30873354
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30134691
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29717087
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27691745
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27690132
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27194613
79* TCF4_18268006_ChIP-ChIP_LS174T_Human1.25526611
80TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25481197
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24507785
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24304084
83BRD4_25478319_ChIP-Seq_HGPS_Human1.23611554
84* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23237032
85SPI1_23547873_ChIP-Seq_NB4_Human1.22570874
86GATA2_19941826_ChIP-Seq_K562_Human1.21589844
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.20832694
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.20805352
89CJUN_26792858_Chip-Seq_BT549_Human1.20418953
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19572481
91GATA3_27048872_Chip-Seq_THYMUS_Human1.19118266
92GATA1_19941826_ChIP-Seq_K562_Human1.18356507
93PU_27001747_Chip-Seq_BMDM_Mouse1.17873555
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.17502976
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16775461
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.16746814
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16600819
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16302096
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16199089
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15908005
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.15226310
102GATA4_25053715_ChIP-Seq_YYC3_Human1.14143186
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13649601
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11441229
105GATA6_25053715_ChIP-Seq_YYC3_Human1.11026154
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10180177
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10148713
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08605874
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08555785
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08301690
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07303248
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.07222061
113TBX20_22080862_ChIP-Seq_HEART_Mouse1.07222061
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07189178
115KDM2B_26808549_Chip-Seq_K562_Human1.07118551
116* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06973332
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.06287386
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05455388
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04008726
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03706683
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02542733
122SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02191801
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01706535
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01062590
125RXR_22108803_ChIP-Seq_LS180_Human1.00255481
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00164646
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.99552300
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99285452
129NCOR1_26117541_ChIP-Seq_K562_Human0.98293409
130ZNF263_19887448_ChIP-Seq_K562_Human0.97726225
131* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96875364
132SOX2_20726797_ChIP-Seq_SW620_Human0.95696157
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95694507
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95261679
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94440753
136SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89762042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.63480699
2MP0003300_gastrointestinal_ulcer3.49405576
3MP0005451_abnormal_body_composition3.33549445
4MP0003705_abnormal_hypodermis_morpholog3.09056453
5MP0003303_peritoneal_inflammation3.05576487
6MP0000569_abnormal_digit_pigmentation2.81986823
7MP0010352_gastrointestinal_tract_polyps2.77724081
8MP0005076_abnormal_cell_differentiation2.70945933
9MP0005365_abnormal_bile_salt2.51440204
10MP0002166_altered_tumor_susceptibility2.39788819
11MP0003172_abnormal_lysosome_physiology2.38428481
12MP0003566_abnormal_cell_adhesion2.23588804
13MP0005360_urolithiasis2.19075660
14MP0009278_abnormal_bone_marrow2.15614862
15MP0003195_calcinosis2.11954518
16MP0002006_tumorigenesis2.05609112
17MP0010234_abnormal_vibrissa_follicle2.05536988
18MP0001666_abnormal_nutrient_absorption2.04111218
19MP0005085_abnormal_gallbladder_physiolo2.00521346
20MP0003656_abnormal_erythrocyte_physiolo1.99189874
21MP0010329_abnormal_lipoprotein_level1.98698664
22MP0008438_abnormal_cutaneous_collagen1.97818250
23MP0004130_abnormal_muscle_cell1.92800997
24MP0004185_abnormal_adipocyte_glucose1.91721400
25MP0003122_maternal_imprinting1.91710660
26MP0004808_abnormal_hematopoietic_stem1.90984479
27MP0003252_abnormal_bile_duct1.89393416
28MP0002877_abnormal_melanocyte_morpholog1.88018316
29MP0003828_pulmonary_edema1.82911388
30MP0005409_darkened_coat_color1.80428773
31MP0003436_decreased_susceptibility_to1.75081799
32MP0006054_spinal_hemorrhage1.69936132
33MP0005275_abnormal_skin_tensile1.68453335
34MP0001835_abnormal_antigen_presentation1.66203279
35MP0009840_abnormal_foam_cell1.63856485
36MP0001879_abnormal_lymphatic_vessel1.60568787
37MP0003045_fibrosis1.59841377
38MP0010368_abnormal_lymphatic_system1.56697499
39MP0004947_skin_inflammation1.54786219
40MP0001545_abnormal_hematopoietic_system1.53673046
41MP0005397_hematopoietic_system_phenotyp1.53673046
42MP0003868_abnormal_feces_composition1.53392054
43MP0000685_abnormal_immune_system1.52366352
44MP0000733_abnormal_muscle_development1.50490252
45MP0003448_altered_tumor_morphology1.46178414
46MP0010307_abnormal_tumor_latency1.45901457
47MP0005408_hypopigmentation1.45852772
48MP0003091_abnormal_cell_migration1.43264155
49MP0000609_abnormal_liver_physiology1.43204059
50MP0002009_preneoplasia1.42752338
51MP0005666_abnormal_adipose_tissue1.40549025
52MP0005671_abnormal_response_to1.39293525
53MP0002396_abnormal_hematopoietic_system1.38359276
54MP0003950_abnormal_plasma_membrane1.37047949
55MP0010155_abnormal_intestine_physiology1.36630493
56MP0009780_abnormal_chondrocyte_physiolo1.34964341
57MP0005164_abnormal_response_to1.34830729
58MP0005387_immune_system_phenotype1.34218025
59MP0001790_abnormal_immune_system1.34218025
60MP0008961_abnormal_basal_metabolism1.34103313
61MP0001800_abnormal_humoral_immune1.33308589
62MP0002452_abnormal_antigen_presenting1.33055646
63MP0005000_abnormal_immune_tolerance1.32165869
64MP0009333_abnormal_splenocyte_physiolog1.30235315
65MP0008260_abnormal_autophagy1.29598084
66MP0009785_altered_susceptibility_to1.29194042
67MP0004883_abnormal_blood_vessel1.27931899
68MP0003724_increased_susceptibility_to1.27579406
69MP0003763_abnormal_thymus_physiology1.26367380
70MP0001533_abnormal_skeleton_physiology1.25872558
71MP0001873_stomach_inflammation1.25827205
72MP0000604_amyloidosis1.25716888
73MP0002419_abnormal_innate_immunity1.25134547
74MP0005375_adipose_tissue_phenotype1.24696001
75MP0004272_abnormal_basement_membrane1.24049684
76MP0002405_respiratory_system_inflammati1.23671270
77MP0002420_abnormal_adaptive_immunity1.21712346
78MP0001819_abnormal_immune_cell1.21490580
79MP0008469_abnormal_protein_level1.21150975
80MP0002132_abnormal_respiratory_system1.19708876
81MP0004264_abnormal_extraembryonic_tissu1.16638094
82MP0005025_abnormal_response_to1.15949699
83* MP0002998_abnormal_bone_remodeling1.15009232
84MP0003279_aneurysm1.14806539
85MP0002723_abnormal_immune_serum1.14154655
86MP0004510_myositis1.14036701
87MP0000858_altered_metastatic_potential1.13476931
88MP0005464_abnormal_platelet_physiology1.12227124
89MP0002398_abnormal_bone_marrow1.10700062
90MP0000003_abnormal_adipose_tissue1.10188983
91MP0005167_abnormal_blood-brain_barrier1.09585107
92MP0002118_abnormal_lipid_homeostasis1.09362167
93MP0005023_abnormal_wound_healing1.07749026
94MP0008875_abnormal_xenobiotic_pharmacok1.05088903
95MP0009115_abnormal_fat_cell1.03394116
96MP0003191_abnormal_cellular_cholesterol1.03004218
97MP0001958_emphysema1.02864524
98MP0008004_abnormal_stomach_pH1.00967761
99MP0003866_abnormal_defecation0.99785863
100MP0001849_ear_inflammation0.99746401
101MP0000343_altered_response_to0.99328111
102MP0000465_gastrointestinal_hemorrhage0.98971858
103MP0005670_abnormal_white_adipose0.98574406
104MP0002933_joint_inflammation0.98455861
105MP0003690_abnormal_glial_cell0.95908106
106MP0000716_abnormal_immune_system0.94337334
107MP0000767_abnormal_smooth_muscle0.94276419
108MP0010678_abnormal_skin_adnexa0.92458563
109MP0010630_abnormal_cardiac_muscle0.91969348
110MP0002925_abnormal_cardiovascular_devel0.91530164
111MP0003453_abnormal_keratinocyte_physiol0.90272757
112MP0000703_abnormal_thymus_morphology0.88803832
113MP0000598_abnormal_liver_morphology0.88329241
114MP0003075_altered_response_to0.87928880
115MP0000689_abnormal_spleen_morphology0.87446861
116MP0000249_abnormal_blood_vessel0.86918691
117MP0001851_eye_inflammation0.86155193
118MP0001845_abnormal_inflammatory_respons0.84999807
119MP0004084_abnormal_cardiac_muscle0.84752002
120MP0005319_abnormal_enzyme/_coenzyme0.83677625
121MP0000383_abnormal_hair_follicle0.82900361
122MP0002148_abnormal_hypersensitivity_rea0.82325888
123MP0002722_abnormal_immune_system0.81992597
124MP0000371_diluted_coat_color0.81946021
125MP0001853_heart_inflammation0.81304330
126MP0002138_abnormal_hepatobiliary_system0.80842280
127MP0005058_abnormal_lysosome_morphology0.79715426
128MP0002089_abnormal_postnatal_growth/wei0.78158865
129MP0002086_abnormal_extraembryonic_tissu0.77827813
130MP0001915_intracranial_hemorrhage0.77661356
131MP0002128_abnormal_blood_circulation0.76725803
132MP0002971_abnormal_brown_adipose0.75516039
133MP0005248_abnormal_Harderian_gland0.75292091
134MP0002429_abnormal_blood_cell0.75263944
135MP0004087_abnormal_muscle_fiber0.74687909
136MP0000013_abnormal_adipose_tissue0.74118911
137MP0006082_CNS_inflammation0.73039449
138MP0003183_abnormal_peptide_metabolism0.72823096

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.86613324
2Abnormality of the common coagulation pathway (HP:0010990)4.55782498
3Hypobetalipoproteinemia (HP:0003563)4.27830952
4Prolonged partial thromboplastin time (HP:0003645)4.08292947
5Joint hemorrhage (HP:0005261)3.84989666
6Complement deficiency (HP:0004431)3.73163560
7Gingival bleeding (HP:0000225)3.59500343
8Hematochezia (HP:0002573)3.33183936
9Flat acetabular roof (HP:0003180)3.28878893
10Acanthocytosis (HP:0001927)3.26922646
11Aortic aneurysm (HP:0004942)3.24798342
12Glomerulonephritis (HP:0000099)3.19847459
13Recurrent gram-negative bacterial infections (HP:0005420)3.18647095
14Cerebral aneurysm (HP:0004944)3.15915345
15Abnormality of complement system (HP:0005339)3.08689269
16Gastrointestinal infarctions (HP:0005244)3.01669347
17Hemorrhage of the eye (HP:0011885)2.99239638
18Xanthomatosis (HP:0000991)2.97146856
19Menorrhagia (HP:0000132)2.95735899
20Systemic lupus erythematosus (HP:0002725)2.85039626
21Hypolipoproteinemia (HP:0010981)2.83017370
22Increased density of long bones (HP:0006392)2.82320025
23Subacute progressive viral hepatitis (HP:0006572)2.81466166
24Hypercholesterolemia (HP:0003124)2.81377263
25Abnormality of the fingertips (HP:0001211)2.81209944
26Spontaneous abortion (HP:0005268)2.68677315
27Peritonitis (HP:0002586)2.64598107
28Eczematoid dermatitis (HP:0000976)2.60834924
29Conjugated hyperbilirubinemia (HP:0002908)2.60808082
30Mitral valve prolapse (HP:0001634)2.59324401
31Protrusio acetabuli (HP:0003179)2.55814232
32Macroorchidism (HP:0000053)2.53859839
33Epistaxis (HP:0000421)2.52519227
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.52328762
35Syringomyelia (HP:0003396)2.49081359
36Spinal cord lesions (HP:0100561)2.49081359
37Abnormality of macrophages (HP:0004311)2.46575001
38Absent frontal sinuses (HP:0002688)2.45897899
39Thrombophlebitis (HP:0004418)2.43534735
40Vascular calcification (HP:0004934)2.41926781
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41117495
42Abnormality of carpal bone ossification (HP:0006257)2.40170100
43Papillary thyroid carcinoma (HP:0002895)2.39037965
44Amyloidosis (HP:0011034)2.37458124
45Purpura (HP:0000979)2.37138897
46Dilatation of the ascending aorta (HP:0005111)2.35265486
47Thoracolumbar scoliosis (HP:0002944)2.34457828
48Aortic dissection (HP:0002647)2.33621226
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.32561162
50Osteolytic defects of the hand bones (HP:0009699)2.32561162
51Abnormal tarsal ossification (HP:0008369)2.31810748
52Pulmonary embolism (HP:0002204)2.31440677
53Short 4th metacarpal (HP:0010044)2.29233328
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29233328
55Abnormality of the peritoneum (HP:0002585)2.28296837
56Shallow orbits (HP:0000586)2.27639675
57Autoimmune thrombocytopenia (HP:0001973)2.27220021
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26527232
59Abnormal foot bone ossification (HP:0010675)2.24812409
60Persistence of primary teeth (HP:0006335)2.24690545
61Mitral stenosis (HP:0001718)2.24474678
62Recurrent bacterial skin infections (HP:0005406)2.23348356
63Cardiovascular calcification (HP:0011915)2.18263454
64Joint swelling (HP:0001386)2.15107929
65Striae distensae (HP:0001065)2.14698058
66Episodic fever (HP:0001954)2.13006955
67Small epiphyses (HP:0010585)2.12921587
68Hyperacusis (HP:0010780)2.12758604
69Spondylolisthesis (HP:0003302)2.12757637
70Polycythemia (HP:0001901)2.12413008
71Disinhibition (HP:0000734)2.12377586
72Fat malabsorption (HP:0002630)2.11778363
73Arterial thrombosis (HP:0004420)2.10635596
74Recurrent fungal infections (HP:0002841)2.09198588
75T lymphocytopenia (HP:0005403)2.08561675
76Esophageal varix (HP:0002040)2.07193640
77Arterial tortuosity (HP:0005116)2.07038693
78Aneurysm (HP:0002617)2.06281207
79Increased connective tissue (HP:0009025)2.05816051
80Myositis (HP:0100614)2.04391614
81Long eyelashes (HP:0000527)2.03300449
82Periodontitis (HP:0000704)2.02303458
83Skin nodule (HP:0200036)2.01934791
84Bicuspid aortic valve (HP:0001647)2.01491109
85Epidermoid cyst (HP:0200040)2.01072643
86Hepatocellular carcinoma (HP:0001402)2.00466301
87Keratoconjunctivitis sicca (HP:0001097)1.99498159
88Broad alveolar ridges (HP:0000187)1.99452004
89Interstitial pulmonary disease (HP:0006530)1.98764769
90Acute myeloid leukemia (HP:0004808)1.98449481
91Thin bony cortex (HP:0002753)1.98360840
92Urinary glycosaminoglycan excretion (HP:0003541)1.97871899
93Mucopolysacchariduria (HP:0008155)1.97871899
94Abnormality of T cell number (HP:0011839)1.97817982
95Recurrent viral infections (HP:0004429)1.93982922
96Ankle contracture (HP:0006466)1.92346412
97Gingivitis (HP:0000230)1.91644560
98Dislocated radial head (HP:0003083)1.91631939
99Abnormal ossification of hand bones (HP:0005921)1.91530193
100Enlarged penis (HP:0000040)1.90538916
101Poikilocytosis (HP:0004447)1.90488337
102Toxemia of pregnancy (HP:0100603)1.90477797
103Cupped ribs (HP:0000887)1.90124554
104Orchitis (HP:0100796)1.90070308
105Vasculitis (HP:0002633)1.88013331
106Acute hepatic failure (HP:0006554)1.86495812
107Arthropathy (HP:0003040)1.85547315
108* Narrow palate (HP:0000189)1.85508286
109Fatigue (HP:0012378)1.85336503
110Asymmetry of the thorax (HP:0001555)1.84107487
111Abnormality of the 4th metacarpal (HP:0010012)1.83850868
112Cellulitis (HP:0100658)1.83454428
113Nephritis (HP:0000123)1.82895734
114Vascular tortuosity (HP:0004948)1.82763681
115Myocardial infarction (HP:0001658)1.81667077
116Exercise-induced myalgia (HP:0003738)1.80893916
117Dysostosis multiplex (HP:0000943)1.80859961
118Pulmonary infiltrates (HP:0002113)1.80652848
119Abnormal hand bone ossification (HP:0010660)1.79837677
120Flared iliac wings (HP:0002869)1.79768057
121Recurrent skin infections (HP:0001581)1.79714555
122Spontaneous hematomas (HP:0007420)1.79236482
123Vertebral arch anomaly (HP:0008438)1.78962018
124Chest pain (HP:0100749)1.77946643
125Broad metatarsal (HP:0001783)1.76635499
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76429573
127Abnormal platelet volume (HP:0011876)1.75258859
128Abnormality of polysaccharide metabolism (HP:0011012)1.75257350
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75257350
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75257350
131Type 1 muscle fiber predominance (HP:0003803)1.74815985
132Glomerulopathy (HP:0100820)1.74289406
133Gangrene (HP:0100758)1.73662710
134Keratoconjunctivitis (HP:0001096)1.73461519
135Urethral obstruction (HP:0000796)1.73278695
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72842541
137Pancreatic islet-cell hyperplasia (HP:0004510)1.72388221
138Abnormality of oral frenula (HP:0000190)1.72087840
139Papilledema (HP:0001085)1.71645630
140Pustule (HP:0200039)1.71614925
141Viral hepatitis (HP:0006562)1.70512011
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.70360963
143Thrombocytosis (HP:0001894)1.69816563
144Volvulus (HP:0002580)1.69579951
145Hypoalphalipoproteinemia (HP:0003233)1.68764898
146Frequent falls (HP:0002359)1.68359666
147Increased mean platelet volume (HP:0011877)1.68336919
148Metaphyseal irregularity (HP:0003025)1.67916968
149Dysmetric saccades (HP:0000641)1.66292038
150Milia (HP:0001056)1.64802138
151Exostoses (HP:0100777)1.64769911
152Camptodactyly of toe (HP:0001836)1.64485351
153Deep philtrum (HP:0002002)1.64433384
154Recurrent abscess formation (HP:0002722)1.63449683
155Difficulty running (HP:0009046)1.60963985
156Optic neuritis (HP:0100653)1.60334679
157Retrobulbar optic neuritis (HP:0100654)1.60334679
158* Rectal prolapse (HP:0002035)1.59823222
159Ankyloglossia (HP:0010296)1.58865891
160Gastrointestinal inflammation (HP:0004386)1.57174406
161Hyporeflexia of lower limbs (HP:0002600)1.56578374
162Renal duplication (HP:0000075)1.55383753
163Ureteral stenosis (HP:0000071)1.54766448
164Increased IgE level (HP:0003212)1.54375024
165Ureteral obstruction (HP:0006000)1.54132205
166Cervical subluxation (HP:0003308)1.53991632
167Transitional cell carcinoma of the bladder (HP:0006740)1.53725431
168Atrophic scars (HP:0001075)1.52712869
169Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.51994376
170Increased cerebral lipofuscin (HP:0011813)1.51708624
171Disproportionate tall stature (HP:0001519)1.51371163
172Slender build (HP:0001533)1.51357205
173Prolonged bleeding time (HP:0003010)1.51266728
174Abnormality of the right ventricle (HP:0001707)1.50987925
175Abnormality of the left ventricular outflow tract (HP:0011103)1.50479759
176Subaortic stenosis (HP:0001682)1.50479759
177Lymphangioma (HP:0100764)1.49956082
178Radial bowing (HP:0002986)1.49607186
179Inflammation of the large intestine (HP:0002037)1.49432460
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.48398295
181Hypercortisolism (HP:0001578)1.47985248
182Abnormality of the nasal mucosa (HP:0000433)1.47892473
183Gastrointestinal carcinoma (HP:0002672)1.47684158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.73303597
2EEF2K2.79618980
3PKN22.66041976
4RIPK12.64123424
5CAMK1D2.27861757
6MAP4K12.26312428
7TTN2.24128456
8PRPF4B2.21375973
9CDK122.00184677
10JAK31.98583723
11PTK61.98286834
12CAMK1G1.96117015
13MAP2K31.88389011
14IRAK31.87036070
15CDK61.82048600
16MAP3K131.79162207
17MAP3K101.76091661
18SIK11.74818507
19TGFBR21.71520670
20LATS11.69316149
21JAK11.69124487
22DMPK1.58020297
23LRRK21.55171632
24STK101.54015411
25SCYL21.54006842
26TXK1.44190612
27FRK1.43639780
28PDGFRA1.42744913
29BLK1.38943840
30NEK91.37087482
31TAOK11.33302023
32AKT31.32011298
33FGR1.31491743
34ZAP701.27842989
35ERN11.26755284
36YES11.26318067
37RPS6KA41.24200295
38* FGFR31.23603231
39MAPK111.22709341
40PDGFRB1.21684523
41RET1.17779359
42PRKAA21.15204497
43TYK21.14587038
44NLK1.13008333
45EPHB11.11408770
46STK31.11347665
47PRKCH1.10637471
48ITK1.10533426
49JAK21.10081000
50FGFR41.10028384
51IRAK41.08635558
52MAP3K31.07590553
53MAP3K141.06923048
54BMX1.05351847
55OBSCN1.05031864
56ALK1.00970263
57HCK1.00844085
58MAP2K61.00168138
59PIK3CG0.99545481
60SGK30.99284658
61CDC42BPA0.99136115
62TRPM70.98624268
63BMPR20.98101422
64WNK40.95963367
65SIK20.95158974
66TYRO30.95114520
67EPHA30.94416596
68CAMKK20.94386080
69MAP3K20.93375497
70CSK0.92034009
71TGFBR10.90757132
72MTOR0.88824544
73RIPK40.87168482
74TBK10.86787165
75CDK90.85925900
76STK240.85676390
77FES0.85220771
78MAP3K70.84922004
79KIT0.83704826
80TAOK30.83564506
81MARK30.82564336
82IRAK10.81834622
83PAK40.79685878
84SMG10.79171600
85CHUK0.78371550
86LMTK20.72143324
87* PDK10.71354108
88TIE10.70890644
89EPHB20.69210639
90BTK0.68813704
91* PDPK10.68427646
92GRK60.68276013
93CDK40.67772358
94MATK0.66866278
95LCK0.65079392
96DYRK1B0.64823877
97IKBKE0.64369390
98PAK20.62211935
99FGFR20.61850036
100MAPK120.60380999
101PTK20.60210094
102ICK0.59789939
103PIK3CA0.58463199
104CAMKK10.58351779
105RPS6KA20.58183817
106LYN0.56574863
107CSF1R0.56382908
108HIPK20.55236776
109SGK2230.54969105
110SGK4940.54969105
111TEC0.53296222
112SGK10.52698128
113FER0.52453752
114EGFR0.51667447
115PIM10.50072335
116IRAK20.46082273
117SYK0.45524342
118IGF1R0.45152123
119MAP3K80.44266110
120NEK20.43878070
121WNK10.43709454
122KSR20.43356372
123BRD40.42678490
124PRKD10.42502756
125MARK20.42181558
126SGK20.41965134
127MAP3K50.41523122
128DDR20.40984938
129MAPKAPK30.40285836
130MST1R0.39819952
131PRKG20.39381260
132MAP3K10.39307719
133MELK0.39258866
134ERBB20.37492095
135NEK60.35711272
136STK390.35637949

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.84528947
2Staphylococcus aureus infection_Homo sapiens_hsa051502.62276383
3Other glycan degradation_Homo sapiens_hsa005112.47330639
4Leishmaniasis_Homo sapiens_hsa051401.93189381
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90380583
6Osteoclast differentiation_Homo sapiens_hsa043801.81158095
7Chronic myeloid leukemia_Homo sapiens_hsa052201.65734234
8Toxoplasmosis_Homo sapiens_hsa051451.62608519
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60974788
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53860836
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.52725560
12Fatty acid biosynthesis_Homo sapiens_hsa000611.50977218
13Fat digestion and absorption_Homo sapiens_hsa049751.46164326
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46003098
15Viral myocarditis_Homo sapiens_hsa054161.45328907
16B cell receptor signaling pathway_Homo sapiens_hsa046621.42087455
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.41443943
18Platelet activation_Homo sapiens_hsa046111.41292836
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40683127
20Focal adhesion_Homo sapiens_hsa045101.38111854
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35161329
22Proteoglycans in cancer_Homo sapiens_hsa052051.34769144
23Adherens junction_Homo sapiens_hsa045201.32849380
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32508053
25Pancreatic cancer_Homo sapiens_hsa052121.31805303
26T cell receptor signaling pathway_Homo sapiens_hsa046601.30811454
27PPAR signaling pathway_Homo sapiens_hsa033201.30539185
28Small cell lung cancer_Homo sapiens_hsa052221.30405261
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28513403
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28125874
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.27097185
32Starch and sucrose metabolism_Homo sapiens_hsa005001.25765724
33TNF signaling pathway_Homo sapiens_hsa046681.24250404
34Measles_Homo sapiens_hsa051621.23515338
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22305084
36Acute myeloid leukemia_Homo sapiens_hsa052211.22088626
37* Neurotrophin signaling pathway_Homo sapiens_hsa047221.21817891
38Amoebiasis_Homo sapiens_hsa051461.21690790
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20990701
40Arginine biosynthesis_Homo sapiens_hsa002201.19019476
41Antigen processing and presentation_Homo sapiens_hsa046121.18681687
42ECM-receptor interaction_Homo sapiens_hsa045121.16358865
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15859176
44* mTOR signaling pathway_Homo sapiens_hsa041501.14426377
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.13327888
46Tuberculosis_Homo sapiens_hsa051521.13151261
47Dorso-ventral axis formation_Homo sapiens_hsa043201.10571819
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10547473
49VEGF signaling pathway_Homo sapiens_hsa043701.10410340
50Hepatitis B_Homo sapiens_hsa051611.06603120
51* Insulin resistance_Homo sapiens_hsa049311.06154781
52Salmonella infection_Homo sapiens_hsa051321.05401570
53Non-small cell lung cancer_Homo sapiens_hsa052231.05282308
54Chemokine signaling pathway_Homo sapiens_hsa040621.05178861
55Prolactin signaling pathway_Homo sapiens_hsa049171.04925955
56Malaria_Homo sapiens_hsa051441.03895903
57Colorectal cancer_Homo sapiens_hsa052101.03572027
58Shigellosis_Homo sapiens_hsa051311.03422631
59Hematopoietic cell lineage_Homo sapiens_hsa046401.03409804
60MicroRNAs in cancer_Homo sapiens_hsa052061.02002458
61Type II diabetes mellitus_Homo sapiens_hsa049301.01918931
62Endometrial cancer_Homo sapiens_hsa052131.00889833
63Influenza A_Homo sapiens_hsa051641.00068829
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.98777589
65Pertussis_Homo sapiens_hsa051330.98125472
66Fatty acid degradation_Homo sapiens_hsa000710.98098515
67Glioma_Homo sapiens_hsa052140.96902217
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.96165971
69Renal cell carcinoma_Homo sapiens_hsa052110.93976105
70Legionellosis_Homo sapiens_hsa051340.91159305
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90789209
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90518426
73Apoptosis_Homo sapiens_hsa042100.89915392
74ABC transporters_Homo sapiens_hsa020100.89675544
75Vitamin digestion and absorption_Homo sapiens_hsa049770.89215647
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87955310
77HIF-1 signaling pathway_Homo sapiens_hsa040660.87565613
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86785377
79HTLV-I infection_Homo sapiens_hsa051660.86502677
80Graft-versus-host disease_Homo sapiens_hsa053320.86305450
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85898360
82Thyroid cancer_Homo sapiens_hsa052160.84991107
83FoxO signaling pathway_Homo sapiens_hsa040680.84435239
84Renin secretion_Homo sapiens_hsa049240.83682908
85Primary immunodeficiency_Homo sapiens_hsa053400.83264808
86Insulin signaling pathway_Homo sapiens_hsa049100.83125187
87Renin-angiotensin system_Homo sapiens_hsa046140.82888799
88Rap1 signaling pathway_Homo sapiens_hsa040150.82854659
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81451634
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81087331
91Inositol phosphate metabolism_Homo sapiens_hsa005620.79295151
92Prostate cancer_Homo sapiens_hsa052150.76855771
93AMPK signaling pathway_Homo sapiens_hsa041520.76755835
94Estrogen signaling pathway_Homo sapiens_hsa049150.75418071
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75312271
96Dilated cardiomyopathy_Homo sapiens_hsa054140.74596596
97Herpes simplex infection_Homo sapiens_hsa051680.74436933
98Hepatitis C_Homo sapiens_hsa051600.73072153
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.72730219
100Pathways in cancer_Homo sapiens_hsa052000.71264418
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70617204
102Lysosome_Homo sapiens_hsa041420.70600518
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70428691
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69851533
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69704357
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69658043
107Endocytosis_Homo sapiens_hsa041440.69279633
108Fatty acid metabolism_Homo sapiens_hsa012120.69127738
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.68587019
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.68371653
111Prion diseases_Homo sapiens_hsa050200.68281359
112Histidine metabolism_Homo sapiens_hsa003400.67872422
113Choline metabolism in cancer_Homo sapiens_hsa052310.67621219
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67450524
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66364923
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65602469
117Allograft rejection_Homo sapiens_hsa053300.63926255
118TGF-beta signaling pathway_Homo sapiens_hsa043500.63855876
119* MAPK signaling pathway_Homo sapiens_hsa040100.62385005
120African trypanosomiasis_Homo sapiens_hsa051430.62176830
121Bile secretion_Homo sapiens_hsa049760.61862005
122GnRH signaling pathway_Homo sapiens_hsa049120.61482547
123Notch signaling pathway_Homo sapiens_hsa043300.59130342
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.59083087
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58945765
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58746099
127Glucagon signaling pathway_Homo sapiens_hsa049220.58286952
128Autoimmune thyroid disease_Homo sapiens_hsa053200.56605074
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56451621
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55498451
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55254604
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.54727546
133ErbB signaling pathway_Homo sapiens_hsa040120.53370295
134Bladder cancer_Homo sapiens_hsa052190.50175250
135Type I diabetes mellitus_Homo sapiens_hsa049400.48654733
136Galactose metabolism_Homo sapiens_hsa000520.47476201

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