RPS4XP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.90843278
2establishment of protein localization to mitochondrial membrane (GO:0090151)7.52695973
3viral transcription (GO:0019083)6.59969110
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.56659253
5ATP synthesis coupled proton transport (GO:0015986)6.56659253
6regulation of DNA methylation (GO:0044030)6.35256488
7ribosomal small subunit biogenesis (GO:0042274)6.27063345
8translational termination (GO:0006415)6.24492645
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.54040918
10translational elongation (GO:0006414)5.51435485
11glyoxylate metabolic process (GO:0046487)5.45352841
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.37675590
13cotranslational protein targeting to membrane (GO:0006613)5.27581864
14ribosomal small subunit assembly (GO:0000028)5.25472408
15protein targeting to ER (GO:0045047)5.21894745
16DNA deamination (GO:0045006)5.07640731
17maturation of SSU-rRNA (GO:0030490)4.99030752
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98556365
19viral life cycle (GO:0019058)4.92442965
20protein localization to endoplasmic reticulum (GO:0070972)4.89234837
21cellular protein complex disassembly (GO:0043624)4.83065065
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.61477242
23GDP-mannose metabolic process (GO:0019673)4.27708957
24ectoderm development (GO:0007398)4.13404843
25inner mitochondrial membrane organization (GO:0007007)4.10706812
26translational initiation (GO:0006413)4.08358717
27behavioral response to nicotine (GO:0035095)4.08063344
28protein complex disassembly (GO:0043241)3.92663050
29intracellular protein transmembrane import (GO:0044743)3.82435032
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78059278
31protein-cofactor linkage (GO:0018065)3.77141354
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76787753
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.71392467
34NADH dehydrogenase complex assembly (GO:0010257)3.71392467
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71392467
36male meiosis (GO:0007140)3.71310978
37respiratory electron transport chain (GO:0022904)3.70800443
38electron transport chain (GO:0022900)3.70300052
39translation (GO:0006412)3.68010501
40macromolecular complex disassembly (GO:0032984)3.66677794
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65870285
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64939140
43protein targeting to membrane (GO:0006612)3.62930103
44viral protein processing (GO:0019082)3.58003566
45regulation of isotype switching to IgG isotypes (GO:0048302)3.54974192
46ATP biosynthetic process (GO:0006754)3.53954965
47negative regulation of telomere maintenance (GO:0032205)3.45966248
48outer ear morphogenesis (GO:0042473)3.43265088
49protein complex biogenesis (GO:0070271)3.42880132
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.42054132
51nucleoside transmembrane transport (GO:1901642)3.41757313
52female gonad development (GO:0008585)3.40285710
53ribosomal large subunit biogenesis (GO:0042273)3.38374857
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.31758866
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28090657
56thyroid hormone generation (GO:0006590)3.24387632
57mRNA catabolic process (GO:0006402)3.20825664
58cytidine metabolic process (GO:0046087)3.19704964
59cytidine catabolic process (GO:0006216)3.19704964
60cytidine deamination (GO:0009972)3.19704964
61mitochondrial respiratory chain complex assembly (GO:0033108)3.13186835
62pseudouridine synthesis (GO:0001522)3.11655387
63interferon-gamma production (GO:0032609)3.10406687
64cellular component biogenesis (GO:0044085)3.06640156
65hydrogen ion transmembrane transport (GO:1902600)3.01452634
66mannose metabolic process (GO:0006013)2.93417562
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88870604
68mast cell activation (GO:0045576)2.87489373
69heart trabecula morphogenesis (GO:0061384)2.85974718
70ribonucleoprotein complex biogenesis (GO:0022613)2.83582101
71parturition (GO:0007567)2.82331292
72thyroid hormone metabolic process (GO:0042403)2.81306969
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80617374
74RNA catabolic process (GO:0006401)2.80126747
75somatic hypermutation of immunoglobulin genes (GO:0016446)2.76733663
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76733663
77cranial suture morphogenesis (GO:0060363)2.75567673
78nucleoside transport (GO:0015858)2.74613154
79response to pheromone (GO:0019236)2.72740704
80positive regulation of T cell apoptotic process (GO:0070234)2.71202197
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.69587175
82intracellular protein transmembrane transport (GO:0065002)2.69281070
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68605904
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68605904
85proton transport (GO:0015992)2.62492075
86positive regulation of fatty acid transport (GO:2000193)2.62165370
87GTP biosynthetic process (GO:0006183)2.61471221
88hydrogen transport (GO:0006818)2.58730841
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57835364
90water-soluble vitamin biosynthetic process (GO:0042364)2.57813116
91endoderm formation (GO:0001706)2.57547622
92negative regulation of T cell differentiation in thymus (GO:0033085)2.57318501
93protein targeting to mitochondrion (GO:0006626)2.56971071
94establishment of protein localization to membrane (GO:0090150)2.56871876
95pyrimidine ribonucleoside catabolic process (GO:0046133)2.54924348
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.54240171
97regulation of histone phosphorylation (GO:0033127)2.52223779
98regulation of chronic inflammatory response (GO:0002676)2.52029357
99positive regulation of transcription regulatory region DNA binding (GO:2000679)2.51705315
100chaperone-mediated protein transport (GO:0072321)11.3909903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.55735835
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.21153651
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06904226
4VDR_22108803_ChIP-Seq_LS180_Human3.50446760
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.43122224
6IGF1R_20145208_ChIP-Seq_DFB_Human3.38098591
7IRF1_19129219_ChIP-ChIP_H3396_Human2.91504137
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.89248082
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88186251
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.69869091
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.55131705
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54532997
13EZH2_22144423_ChIP-Seq_EOC_Human2.49347875
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30125085
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24225922
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21351918
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05156625
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.03069985
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.96158691
20ZNF274_21170338_ChIP-Seq_K562_Hela1.95858448
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77348226
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71758686
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68781170
24VDR_23849224_ChIP-Seq_CD4+_Human1.65788818
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54968782
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53104747
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51367453
28NANOG_20526341_ChIP-Seq_ESCs_Human1.51000558
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43083744
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43062259
31FOXP3_21729870_ChIP-Seq_TREG_Human1.40863789
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.38912594
33TP53_22573176_ChIP-Seq_HFKS_Human1.38810849
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.38782788
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36272132
36EWS_26573619_Chip-Seq_HEK293_Human1.31941274
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.31491911
38ELK1_19687146_ChIP-ChIP_HELA_Human1.28500467
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.28275655
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24350865
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24331148
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21432016
43EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.21098970
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17796230
45TAF2_19829295_ChIP-Seq_ESCs_Human1.17400658
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16988407
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.16179648
48TTF2_22483619_ChIP-Seq_HELA_Human1.15220613
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14927221
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14336147
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14249759
52GATA6_21074721_ChIP-Seq_CACO-2_Human1.12995897
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12214602
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10949441
55FUS_26573619_Chip-Seq_HEK293_Human1.07871086
56FOXH1_21741376_ChIP-Seq_ESCs_Human1.07041618
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.05626532
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04886815
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03812188
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03513389
61NCOR_22424771_ChIP-Seq_293T_Human1.03189437
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02099697
63E2F1_20622854_ChIP-Seq_HELA_Human1.01158575
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.00334982
65KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98824144
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98099069
67CBX2_27304074_Chip-Seq_ESCs_Mouse0.97519421
68P53_21459846_ChIP-Seq_SAOS-2_Human0.96155501
69RBPJ_21746931_ChIP-Seq_IB4_Human0.96074056
70IRF8_22096565_ChIP-ChIP_GC-B_Human0.94828619
71ERA_21632823_ChIP-Seq_H3396_Human0.94391634
72MYC_19829295_ChIP-Seq_ESCs_Human0.94228097
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93693629
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.93652041
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93144934
76MYC_18940864_ChIP-ChIP_HL60_Human0.92527298
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92398849
78STAT1_20625510_ChIP-Seq_HELA_Human0.92326156
79TP53_20018659_ChIP-ChIP_R1E_Mouse0.92090951
80RUNX_20019798_ChIP-Seq_JUKART_Human0.91671596
81EZH2_27304074_Chip-Seq_ESCs_Mouse0.91375438
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90985191
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.90985191
84GBX2_23144817_ChIP-Seq_PC3_Human0.90575405
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89845781
86XRN2_22483619_ChIP-Seq_HELA_Human0.89464665
87EZH2_27294783_Chip-Seq_ESCs_Mouse0.88922416
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88450956
89PHF8_20622853_ChIP-Seq_HELA_Human0.88274610
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88270600
91DCP1A_22483619_ChIP-Seq_HELA_Human0.87518440
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86968328
93CBP_20019798_ChIP-Seq_JUKART_Human0.86574749
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86574749
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86150669
96RNF2_27304074_Chip-Seq_NSC_Mouse0.84825360
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84403286
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84165906
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.84099116
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83996185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.87602823
2MP0009379_abnormal_foot_pigmentation4.38868220
3MP0005671_abnormal_response_to3.32963943
4MP0002876_abnormal_thyroid_physiology2.98771252
5MP0006072_abnormal_retinal_apoptosis2.67285308
6MP0003786_premature_aging2.65820305
7MP0001986_abnormal_taste_sensitivity2.52778949
8MP0008875_abnormal_xenobiotic_pharmacok2.33568063
9MP0003646_muscle_fatigue2.20789725
10MP0001835_abnormal_antigen_presentation2.19079493
11MP0002638_abnormal_pupillary_reflex2.18585538
12MP0004885_abnormal_endolymph2.13326877
13MP0009333_abnormal_splenocyte_physiolog2.09210756
14MP0005377_hearing/vestibular/ear_phenot1.97253289
15MP0003878_abnormal_ear_physiology1.97253289
16MP0003195_calcinosis1.96988302
17MP0002653_abnormal_ependyma_morphology1.94959851
18MP0006276_abnormal_autonomic_nervous1.89802027
19MP0005646_abnormal_pituitary_gland1.75872906
20MP0004142_abnormal_muscle_tone1.71289938
21MP0006082_CNS_inflammation1.64995786
22MP0003763_abnormal_thymus_physiology1.52602505
23MP0001529_abnormal_vocalization1.51941686
24MP0005387_immune_system_phenotype1.51209044
25MP0001790_abnormal_immune_system1.51209044
26MP0001485_abnormal_pinna_reflex1.50664971
27MP0008872_abnormal_physiological_respon1.49450197
28MP0004742_abnormal_vestibular_system1.43282553
29MP0006292_abnormal_olfactory_placode1.42874355
30MP0009764_decreased_sensitivity_to1.39626930
31MP0002148_abnormal_hypersensitivity_rea1.34338001
32MP0005389_reproductive_system_phenotype1.34023128
33MP0002837_dystrophic_cardiac_calcinosis1.28573841
34MP0001727_abnormal_embryo_implantation1.27804703
35MP0005000_abnormal_immune_tolerance1.26837265
36MP0001800_abnormal_humoral_immune1.21845125
37MP0001968_abnormal_touch/_nociception1.21699571
38MP0002163_abnormal_gland_morphology1.21291381
39MP0001984_abnormal_olfaction1.20689187
40MP0005551_abnormal_eye_electrophysiolog1.19293287
41MP0009785_altered_susceptibility_to1.18906842
42MP0001919_abnormal_reproductive_system1.18811907
43MP0003806_abnormal_nucleotide_metabolis1.18561335
44MP0001440_abnormal_grooming_behavior1.17545993
45MP0004145_abnormal_muscle_electrophysio1.17488477
46MP0001905_abnormal_dopamine_level1.17153110
47MP0002160_abnormal_reproductive_system1.15540919
48MP0001873_stomach_inflammation1.15281516
49MP0002234_abnormal_pharynx_morphology1.14945606
50MP0000685_abnormal_immune_system1.14699785
51MP0002723_abnormal_immune_serum1.13779278
52MP0008775_abnormal_heart_ventricle1.13358191
53MP0000372_irregular_coat_pigmentation1.11175289
54MP0001119_abnormal_female_reproductive1.09462461
55MP0001881_abnormal_mammary_gland1.07484674
56MP0002736_abnormal_nociception_after1.06480079
57MP0009046_muscle_twitch1.06143638
58MP0001542_abnormal_bone_strength1.06030911
59MP0004019_abnormal_vitamin_homeostasis1.03920202
60MP0001501_abnormal_sleep_pattern1.03727174
61MP0003880_abnormal_central_pattern1.03400559
62MP0002277_abnormal_respiratory_mucosa1.02124547
63MP0002420_abnormal_adaptive_immunity1.01324491
64MP0002398_abnormal_bone_marrow1.01126235
65MP0005025_abnormal_response_to1.01078753
66MP0001819_abnormal_immune_cell0.99376710
67MP0005084_abnormal_gallbladder_morpholo0.99210316
68MP0002272_abnormal_nervous_system0.98697244
69MP0003186_abnormal_redox_activity0.98180544
70MP0008877_abnormal_DNA_methylation0.96312505
71MP0003436_decreased_susceptibility_to0.95976630
72MP0003866_abnormal_defecation0.94112065
73MP0005464_abnormal_platelet_physiology0.91477951
74MP0008789_abnormal_olfactory_epithelium0.88521577
75MP0005423_abnormal_somatic_nervous0.87896146
76MP0002102_abnormal_ear_morphology0.87593955
77MP0003936_abnormal_reproductive_system0.86685426
78MP0002210_abnormal_sex_determination0.86296693
79MP0005332_abnormal_amino_acid0.82136105
80MP0005085_abnormal_gallbladder_physiolo0.81965656
81MP0000716_abnormal_immune_system0.81896159
82MP0006036_abnormal_mitochondrial_physio0.81660204
83MP0005253_abnormal_eye_physiology0.79174434
84MP0002429_abnormal_blood_cell0.78351444
85MP0002132_abnormal_respiratory_system0.77651530
86MP0003718_maternal_effect0.76884792
87MP0009745_abnormal_behavioral_response0.75461467
88MP0002452_abnormal_antigen_presenting0.72343580
89MP0000678_abnormal_parathyroid_gland0.72321068
90MP0002095_abnormal_skin_pigmentation0.71441344
91MP0005195_abnormal_posterior_eye0.70672150
92MP0005645_abnormal_hypothalamus_physiol0.70582749
93MP0001970_abnormal_pain_threshold0.70557235
94MP0000049_abnormal_middle_ear0.70479745
95MP0001663_abnormal_digestive_system0.68899432
96MP0002138_abnormal_hepatobiliary_system0.67849669
97MP0002734_abnormal_mechanical_nocicepti0.66371884
98MP0003011_delayed_dark_adaptation0.64634325
99MP0010386_abnormal_urinary_bladder0.62949508
100MP0000343_altered_response_to0.62934057

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)8.11240688
2Duplicated collecting system (HP:0000081)6.30710286
3Abnormality of the renal collecting system (HP:0004742)5.85556274
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.84975560
5Chromsome breakage (HP:0040012)4.90406691
6Abnormality of pyrimidine metabolism (HP:0004353)4.66736810
7Abnormality of DNA repair (HP:0003254)4.57705126
8Absent thumb (HP:0009777)4.27141133
9Aplastic anemia (HP:0001915)3.92270488
10Duplication of thumb phalanx (HP:0009942)3.76024453
11Acute necrotizing encephalopathy (HP:0006965)3.67035749
12Ureteral duplication (HP:0000073)3.59137827
13Oral leukoplakia (HP:0002745)3.55490291
14Increased hepatocellular lipid droplets (HP:0006565)3.46520353
15Ectopic kidney (HP:0000086)3.42124527
16Mitochondrial inheritance (HP:0001427)3.40104019
17Abnormality of the phalanges of the 2nd finger (HP:0009541)3.38183617
18Abnormal mitochondria in muscle tissue (HP:0008316)3.22935826
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.15143722
20Pallor (HP:0000980)3.13902609
21Increased CSF lactate (HP:0002490)3.12580847
22Meckel diverticulum (HP:0002245)3.09567872
23Lipid accumulation in hepatocytes (HP:0006561)3.07583805
24Increased serum pyruvate (HP:0003542)3.03949730
25Acute encephalopathy (HP:0006846)3.01946953
26Progressive macrocephaly (HP:0004481)3.01724026
27Abnormality of the ileum (HP:0001549)3.00233970
28Molar tooth sign on MRI (HP:0002419)2.86149084
29Abnormality of midbrain morphology (HP:0002418)2.86149084
30Pancytopenia (HP:0001876)2.82504682
31Renal Fanconi syndrome (HP:0001994)2.80116526
32Clubbing of toes (HP:0100760)2.75639624
33Cerebral edema (HP:0002181)2.74665578
34Abnormality of the preputium (HP:0100587)2.72234325
35Partial duplication of the phalanx of hand (HP:0009999)2.71034458
36Increased IgM level (HP:0003496)2.65107213
37Congenital, generalized hypertrichosis (HP:0004540)2.62639833
38Eosinophilia (HP:0001880)2.62199127
39Increased intramyocellular lipid droplets (HP:0012240)2.58358658
403-Methylglutaconic aciduria (HP:0003535)2.54740957
41Renal cortical cysts (HP:0000803)2.54438434
42Horseshoe kidney (HP:0000085)2.54304262
43Exertional dyspnea (HP:0002875)2.54238380
44Congenital stationary night blindness (HP:0007642)2.50455205
45Hepatic necrosis (HP:0002605)2.49195104
46Abnormality of cells of the erythroid lineage (HP:0012130)2.46957541
47Hepatocellular necrosis (HP:0001404)2.46106288
48Abnormality of B cell number (HP:0010975)2.44629224
49Enlarged epiphyses (HP:0010580)2.39415220
50Thyroid-stimulating hormone excess (HP:0002925)2.35134786
51Global brain atrophy (HP:0002283)2.34546644
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34473316
53Autoimmune thrombocytopenia (HP:0001973)2.30667789
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26426471
55Hypergonadotropic hypogonadism (HP:0000815)2.23086356
56Abnormality of glycolysis (HP:0004366)2.20908208
57Abnormality of reticulocytes (HP:0004312)2.20706975
58Macrocytic anemia (HP:0001972)2.18404926
59Microretrognathia (HP:0000308)2.15406989
60Increased muscle lipid content (HP:0009058)2.13794985
61Absent radius (HP:0003974)2.13688055
62Stomach cancer (HP:0012126)2.13230846
63Abnormal hemoglobin (HP:0011902)2.12240489
64Hyperglycinemia (HP:0002154)2.11734257
65Elevated erythrocyte sedimentation rate (HP:0003565)2.10608273
66Increased serum lactate (HP:0002151)2.10209736
67Triphalangeal thumb (HP:0001199)2.09432396
68Abnormality of T cell number (HP:0011839)2.08921426
69Aplasia involving forearm bones (HP:0009822)2.06239582
70Absent forearm bone (HP:0003953)2.06239582
71Abnormality of eosinophils (HP:0001879)2.06007317
72Abnormality of the carotid arteries (HP:0005344)2.05073324
73Neutropenia (HP:0001875)2.04502681
74Lactic acidosis (HP:0003128)1.98698088
75Pancreatic fibrosis (HP:0100732)1.96414827
76Pancreatic cysts (HP:0001737)1.95197430
77Decreased central vision (HP:0007663)1.94266582
78True hermaphroditism (HP:0010459)1.93821852
79Abnormality of urine glucose concentration (HP:0011016)1.91184961
80Glycosuria (HP:0003076)1.91184961
81Abnormality of the 2nd finger (HP:0004100)1.90746210
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90349439
83Abnormality of nucleobase metabolism (HP:0010932)1.89358022
84Abnormality of T cells (HP:0002843)1.88241800
85Agitation (HP:0000713)1.88101549
86Granulocytopenia (HP:0001913)1.87200910
87Respiratory difficulties (HP:0002880)1.84449571
88Abnormality of renal resorption (HP:0011038)1.84353195
89Autoimmune hemolytic anemia (HP:0001890)1.78977592
90Abnormality of chromosome stability (HP:0003220)1.76601238
91Optic disc pallor (HP:0000543)1.76533136
92Stomatitis (HP:0010280)1.75737226
93Abnormality of the renal cortex (HP:0011035)1.74536548
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.74390894
95Short thumb (HP:0009778)1.74032528
96Abnormality of the phalanges of the hallux (HP:0010057)1.73780644
97Small intestinal stenosis (HP:0012848)1.72308132
98Duodenal stenosis (HP:0100867)1.72308132
99Hypoproteinemia (HP:0003075)1.70840901
100Nephronophthisis (HP:0000090)1.70292127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.99910843
2MAP4K15.48924366
3BCKDK4.39040726
4STK162.14807784
5TAOK310.5134708
6ADRBK21.70684182
7GRK11.69393577
8TLK11.64464532
9ZAK1.58353270
10NUAK11.46215987
11NME21.45507319
12ZAP701.33528272
13WNK41.22661583
14PIK3CA1.22054161
15TESK21.18592480
16IKBKE1.14763547
17PDK21.03915619
18IKBKB1.02137037
19ITK1.01080923
20SYK0.94271312
21LCK0.91190976
22TIE10.90051319
23FRK0.87614299
24DYRK20.81882573
25TBK10.80748247
26TEC0.73499090
27GRK60.71540326
28INSRR0.71101137
29MAP2K60.66079054
30LYN0.63212494
31BMPR20.62357694
32BTK0.60366384
33NME10.59506396
34PLK40.57735077
35ADRBK10.57391930
36RPS6KA50.56710944
37KIT0.56647659
38PHKG20.56426812
39PHKG10.56426812
40OBSCN0.55718973
41WNK30.55345670
42PINK10.55053300
43MAPK130.54019377
44ATR0.53866298
45PRKCQ0.52801466
46DAPK30.52557488
47MYLK0.50473739
48MAP3K120.49348622
49MAP4K20.49186082
50SGK10.47650173
51CDK190.47069367
52STK390.43975687
53IGF1R0.43898832
54BMPR1B0.43426139
55ABL20.42262457
56AKT20.40906697
57CDC70.40782643
58PASK0.40715318
59PIM10.40595132
60HCK0.37751392
61TRPM70.37583339
62OXSR10.37286327
63JAK30.37194995
64PKN10.36951366
65CSNK2A20.36403705
66CSNK2A10.35965475
67MATK0.33479615
68RPS6KB20.32795440
69MUSK0.31959960
70PRKACA0.31938173
71PRKCA0.31701654
72CSNK1A10.31009210
73CSNK1G10.29819365
74PRKCG0.29696709
75SRPK10.29659107
76PRKCE0.29479474
77MAP3K40.28490448
78MAP2K20.28168518
79DAPK20.27157737
80GRK70.26975152
81RPS6KA10.26016713
82CAMK10.25071967
83LIMK10.24986816
84MAPKAPK50.24810425
85CAMKK20.24809555
86MAPK120.23959808
87PRKCD0.23654222
88GRK50.23492832
89CAMK2A0.23123183
90LRRK20.22725147
91RPS6KA60.22645873
92CSF1R0.22579502
93VRK20.22204798
94PIK3CG0.22065070
95CHEK20.21976945
96KDR0.21788542
97PLK20.21104660
98VRK10.21023769
99EIF2AK10.20838883
100TGFBR10.20637138

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.13678010
2Asthma_Homo sapiens_hsa053103.94781702
3Allograft rejection_Homo sapiens_hsa053303.60774869
4Oxidative phosphorylation_Homo sapiens_hsa001903.58980325
5Autoimmune thyroid disease_Homo sapiens_hsa053203.44125553
6Graft-versus-host disease_Homo sapiens_hsa053322.94028578
7Parkinsons disease_Homo sapiens_hsa050122.92794059
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.81648140
9Type I diabetes mellitus_Homo sapiens_hsa049402.62561857
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50094293
11Proteasome_Homo sapiens_hsa030502.25129393
12Linoleic acid metabolism_Homo sapiens_hsa005911.92741043
13Alzheimers disease_Homo sapiens_hsa050101.90501903
14Cardiac muscle contraction_Homo sapiens_hsa042601.87503478
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77360091
16Huntingtons disease_Homo sapiens_hsa050161.76477331
17Protein export_Homo sapiens_hsa030601.70563988
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68129665
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65892746
20RNA polymerase_Homo sapiens_hsa030201.61106929
21Fanconi anemia pathway_Homo sapiens_hsa034601.58602593
22RNA degradation_Homo sapiens_hsa030181.37424684
23Phototransduction_Homo sapiens_hsa047441.29947956
24One carbon pool by folate_Homo sapiens_hsa006701.23518543
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20882958
26Rheumatoid arthritis_Homo sapiens_hsa053231.16141345
27Staphylococcus aureus infection_Homo sapiens_hsa051501.14499652
28Primary immunodeficiency_Homo sapiens_hsa053401.12527299
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11967382
30Propanoate metabolism_Homo sapiens_hsa006401.11936137
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09948816
32Viral myocarditis_Homo sapiens_hsa054161.09429385
33Ether lipid metabolism_Homo sapiens_hsa005651.06207882
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05184953
35Antigen processing and presentation_Homo sapiens_hsa046121.05028314
36Arachidonic acid metabolism_Homo sapiens_hsa005900.98105979
37Sulfur metabolism_Homo sapiens_hsa009200.96120570
38Mismatch repair_Homo sapiens_hsa034300.95541098
39Hematopoietic cell lineage_Homo sapiens_hsa046400.95326133
40Leishmaniasis_Homo sapiens_hsa051400.83491624
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83230550
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82904358
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82711686
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82509814
45Basal transcription factors_Homo sapiens_hsa030220.81236630
46Systemic lupus erythematosus_Homo sapiens_hsa053220.79807662
47Pyruvate metabolism_Homo sapiens_hsa006200.79171419
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77756257
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74316459
50Pyrimidine metabolism_Homo sapiens_hsa002400.69252453
51Nitrogen metabolism_Homo sapiens_hsa009100.68790789
52Tryptophan metabolism_Homo sapiens_hsa003800.67998039
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67125591
54Nicotine addiction_Homo sapiens_hsa050330.67081462
55Butanoate metabolism_Homo sapiens_hsa006500.66998263
56Purine metabolism_Homo sapiens_hsa002300.65576867
57Caffeine metabolism_Homo sapiens_hsa002320.64882847
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64459395
59Chemical carcinogenesis_Homo sapiens_hsa052040.61996557
60T cell receptor signaling pathway_Homo sapiens_hsa046600.59006618
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58244640
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58157699
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.58103710
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56781063
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55676408
66Homologous recombination_Homo sapiens_hsa034400.55314252
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.55217750
68Fat digestion and absorption_Homo sapiens_hsa049750.54230423
69Morphine addiction_Homo sapiens_hsa050320.53233515
70Olfactory transduction_Homo sapiens_hsa047400.53054232
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.52672707
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51913315
73Collecting duct acid secretion_Homo sapiens_hsa049660.48863564
74Metabolic pathways_Homo sapiens_hsa011000.48745304
75Spliceosome_Homo sapiens_hsa030400.48413474
76Sulfur relay system_Homo sapiens_hsa041220.47516080
77Regulation of autophagy_Homo sapiens_hsa041400.46347122
78Base excision repair_Homo sapiens_hsa034100.45908761
79DNA replication_Homo sapiens_hsa030300.45828250
80Nucleotide excision repair_Homo sapiens_hsa034200.45552650
81Ovarian steroidogenesis_Homo sapiens_hsa049130.44728562
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44507867
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44396201
84Retinol metabolism_Homo sapiens_hsa008300.44366758
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.42536493
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41262130
87Vitamin digestion and absorption_Homo sapiens_hsa049770.39676249
88Peroxisome_Homo sapiens_hsa041460.38521843
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36865445
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33745865
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33463314
92Serotonergic synapse_Homo sapiens_hsa047260.32053014
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31705792
94Malaria_Homo sapiens_hsa051440.31443195
95Vitamin B6 metabolism_Homo sapiens_hsa007500.29322865
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25299115
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.25122752
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24643563
99Salivary secretion_Homo sapiens_hsa049700.24473273
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22766060

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »