RPS29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral life cycle (GO:0019058)9.98681388
2* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)9.70182510
3maturation of SSU-rRNA (GO:0030490)9.28986836
4* translational initiation (GO:0006413)8.71030239
5* protein complex disassembly (GO:0043241)8.56395971
6* macromolecular complex disassembly (GO:0032984)7.95650139
7* protein targeting to membrane (GO:0006612)7.28886554
8ribosomal large subunit biogenesis (GO:0042273)7.28138760
9* nuclear-transcribed mRNA catabolic process (GO:0000956)6.49129003
10* mRNA catabolic process (GO:0006402)6.15150469
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.92279080
12* translation (GO:0006412)5.91466555
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.70161367
14ATP synthesis coupled proton transport (GO:0015986)5.70161367
15* RNA catabolic process (GO:0006401)5.49926775
16ribonucleoprotein complex biogenesis (GO:0022613)5.03477405
17* establishment of protein localization to membrane (GO:0090150)4.89721585
18* protein targeting (GO:0006605)4.38696837
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17904097
20sequestering of actin monomers (GO:0042989)4.12157470
21protein complex biogenesis (GO:0070271)4.10987010
22* establishment of protein localization to organelle (GO:0072594)4.08684142
23* protein localization to membrane (GO:0072657)3.86348902
24mitochondrial respiratory chain complex assembly (GO:0033108)3.85747186
25cellular component biogenesis (GO:0044085)3.83375612
26respiratory electron transport chain (GO:0022904)3.79140173
27rRNA processing (GO:0006364)3.79109911
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.76000236
29electron transport chain (GO:0022900)3.70228878
30rRNA metabolic process (GO:0016072)3.62970646
31behavioral response to nicotine (GO:0035095)3.43366685
32DNA deamination (GO:0045006)3.42257199
33ncRNA 3-end processing (GO:0043628)3.34751826
34GTP biosynthetic process (GO:0006183)3.32928657
35establishment of integrated proviral latency (GO:0075713)3.27050394
36pyrimidine nucleotide catabolic process (GO:0006244)3.22051342
37protein neddylation (GO:0045116)3.20703956
38inner mitochondrial membrane organization (GO:0007007)3.18401719
39* cellular component disassembly (GO:0022411)3.09246596
40UTP biosynthetic process (GO:0006228)3.04588501
41proton transport (GO:0015992)3.02577769
42hydrogen transport (GO:0006818)2.95345734
43intracellular protein transmembrane import (GO:0044743)2.91610562
44neuron fate determination (GO:0048664)2.90263306
45establishment of viral latency (GO:0019043)2.89515988
46spliceosomal complex assembly (GO:0000245)2.88788776
47* protein localization to organelle (GO:0033365)2.87977779
48monocyte chemotaxis (GO:0002548)2.80728818
49viral protein processing (GO:0019082)2.80172610
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.72305682
51eosinophil chemotaxis (GO:0048245)2.71900074
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71548194
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68720534
54regulation of mitochondrial translation (GO:0070129)2.68572757
55nucleoside triphosphate biosynthetic process (GO:0009142)2.68347375
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66475942
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66407819
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66407819
59transcription elongation from RNA polymerase III promoter (GO:0006385)2.65038996
60termination of RNA polymerase III transcription (GO:0006386)2.65038996
61establishment of protein localization to mitochondrion (GO:0072655)2.64563307
62purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60358611
63protein targeting to mitochondrion (GO:0006626)2.59516005
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57083195
65pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55214726
66ATP biosynthetic process (GO:0006754)2.54010919
67oxidative phosphorylation (GO:0006119)2.53362487
68formation of translation preinitiation complex (GO:0001731)2.53001277
69UTP metabolic process (GO:0046051)2.51654400
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.50590301
71negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.50054372
72positive regulation of respiratory burst (GO:0060267)2.49158544
73spliceosomal snRNP assembly (GO:0000387)2.47773014
74keratinocyte development (GO:0003334)2.47547724
75aerobic respiration (GO:0009060)2.47541013
76eosinophil migration (GO:0072677)2.45993472
77mitochondrial transport (GO:0006839)2.45503925
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.45364416
79protein-cofactor linkage (GO:0018065)2.43536880
80protein localization to mitochondrion (GO:0070585)2.43357808
81purine nucleoside monophosphate biosynthetic process (GO:0009127)2.41840058
82purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.41840058
83chromatin remodeling at centromere (GO:0031055)2.40754650
84CTP metabolic process (GO:0046036)2.39760835
85CTP biosynthetic process (GO:0006241)2.39760835
86transcription elongation from RNA polymerase I promoter (GO:0006362)2.36943731
87base-excision repair, AP site formation (GO:0006285)2.32005988
88* gene expression (GO:0010467)2.31807536
89peptidyl-histidine modification (GO:0018202)2.29282669
90tongue development (GO:0043586)2.29160072
91deoxyribonucleotide catabolic process (GO:0009264)2.28282962
92termination of RNA polymerase I transcription (GO:0006363)2.27737690
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.25189242
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.24613518
95cytochrome complex assembly (GO:0017004)2.23846512
96intracellular protein transmembrane transport (GO:0065002)2.23131408
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.22518364
98histone mRNA metabolic process (GO:0008334)2.22336815
99protein transmembrane transport (GO:0071806)2.21523568
100cell proliferation in forebrain (GO:0021846)2.20569034
101rRNA modification (GO:0000154)2.18012629
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.16737981
103guanosine-containing compound biosynthetic process (GO:1901070)2.16418027
104negative regulation of RNA splicing (GO:0033119)2.16222703
105proteasome assembly (GO:0043248)2.15392845
106DNA damage response, detection of DNA damage (GO:0042769)2.13374435
107ncRNA processing (GO:0034470)2.12203653
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.11932104
109negative regulation of ligase activity (GO:0051352)2.10657489
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.10657489
111molting cycle (GO:0042303)2.10345548
112hair cycle (GO:0042633)2.10345548
113hydrogen ion transmembrane transport (GO:1902600)2.10218195
114chaperone-mediated protein transport (GO:0072321)2.09779912
115autophagic vacuole fusion (GO:0000046)2.09614168
116* single-organism cellular localization (GO:1902580)2.09561650
117platelet dense granule organization (GO:0060155)2.08193204
118keratinocyte proliferation (GO:0043616)2.07437508
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.07019821
120mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.06094624
121mitochondrial respiratory chain complex I assembly (GO:0032981)2.06094624
122NADH dehydrogenase complex assembly (GO:0010257)2.06094624
1237-methylguanosine RNA capping (GO:0009452)2.01760847
124RNA capping (GO:0036260)2.01760847
125* viral transcription (GO:0019083)13.6499208
126ribosomal small subunit biogenesis (GO:0042274)13.0948943
127* translational termination (GO:0006415)12.9685314
128ribosomal small subunit assembly (GO:0000028)11.4447513
129* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)10.9338381
130* cotranslational protein targeting to membrane (GO:0006613)10.8467483
131* protein targeting to ER (GO:0045047)10.7921207
132* translational elongation (GO:0006414)10.5634971
133* establishment of protein localization to endoplasmic reticulum (GO:0072599)10.3463037
134* protein localization to endoplasmic reticulum (GO:0070972)10.0736080
135* cellular protein complex disassembly (GO:0043624)10.0365480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat9.36027410
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.81058910
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.66792199
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.12813903
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse4.03691492
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.85042526
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.80067203
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56701304
9EZH2_22144423_ChIP-Seq_EOC_Human3.37799978
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.23938267
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19343827
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17628734
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.17357765
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17215212
15* XRN2_22483619_ChIP-Seq_HELA_Human2.89628062
16TTF2_22483619_ChIP-Seq_HELA_Human2.77098990
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71909538
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53826502
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51628712
20ELK1_19687146_ChIP-ChIP_HELA_Human2.51325075
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28248966
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26258360
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24616902
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20815488
25ELK1_22589737_ChIP-Seq_MCF10A_Human2.16228077
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13309363
27* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.08958445
28KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.03531784
29VDR_23849224_ChIP-Seq_CD4+_Human2.02330181
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94615639
31E2F7_22180533_ChIP-Seq_HELA_Human1.86336319
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83262569
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.83150682
34DCP1A_22483619_ChIP-Seq_HELA_Human1.80553540
35MYC_18940864_ChIP-ChIP_HL60_Human1.78657504
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73035295
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69630885
38FOXP3_21729870_ChIP-Seq_TREG_Human1.68333889
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67632530
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63895227
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62422628
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60369828
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58680943
44IRF1_19129219_ChIP-ChIP_H3396_Human1.57962326
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53779929
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.45122484
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44960015
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43975836
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40746454
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37587610
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37587610
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37587610
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33998791
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31957805
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.30871570
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27470636
57OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26102583
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22528172
59* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21705129
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19959959
61* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15788083
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15410153
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15199296
64* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13602437
65* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11954074
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09293597
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.08912186
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08651563
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07925331
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05253539
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04473040
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.04328312
73FOXP1_21924763_ChIP-Seq_HESCs_Human1.02815890
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02397324
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01888478
76KDM5A_27292631_Chip-Seq_BREAST_Human1.00705416
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00301947
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99863593
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99635675
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.99027642
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97929059
82* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96711685
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96019520
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95410031
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.94427072
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93938349
87* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91227976
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.90314236
89* CTCF_26484167_Chip-Seq_Bcells_Mouse0.89596099
90STAT1_20625510_ChIP-Seq_HELA_Human0.88527653
91VDR_22108803_ChIP-Seq_LS180_Human0.87980444
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87230442
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86388495
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86004244
95P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85822552
96SPI1_23547873_ChIP-Seq_NB4_Human0.84281206
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.82567599
98* VDR_21846776_ChIP-Seq_THP-1_Human0.82452426
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.81847505
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.81772119
101SA1_27219007_Chip-Seq_Bcells_Human0.81614426
102EED_16625203_ChIP-ChIP_MESCs_Mouse0.81530139
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81141466
104EWS_26573619_Chip-Seq_HEK293_Human0.80256008
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80223159
106SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79651291
107RNF2_27304074_Chip-Seq_NSC_Mouse0.79148687
108* SOX2_16153702_ChIP-ChIP_HESCs_Human0.79011890
109ERG_20517297_ChIP-Seq_VCAP_Human0.78629283
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.78591933
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78562628
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.78136657
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78078840
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78031319
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77951090
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.77847487
117NANOG_20526341_ChIP-Seq_ESCs_Human0.77333507
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77084628
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77076690
120* TAF2_19829295_ChIP-Seq_ESCs_Human0.76893200
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75184743
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75083295
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74032111
124GABP_19822575_ChIP-Seq_HepG2_Human0.74017351
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.73978794
126MAF_26560356_Chip-Seq_TH2_Human0.73184887
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.71376310
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70837533
129SCL_19346495_ChIP-Seq_HPC-7_Human0.69581766
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.66041137
131EZH2_27304074_Chip-Seq_ESCs_Mouse0.65304995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.27129578
2MP0004381_abnormal_hair_follicle4.12451557
3MP0003136_yellow_coat_color3.76999282
4MP0003941_abnormal_skin_development3.07413544
5MP0005409_darkened_coat_color2.60118871
6MP0000566_synostosis2.47347625
7MP0002796_impaired_skin_barrier2.35210334
8MP0002653_abnormal_ependyma_morphology2.22851480
9MP0002638_abnormal_pupillary_reflex2.13679377
10MP0002938_white_spotting1.99321553
11MP0002148_abnormal_hypersensitivity_rea1.96162376
12MP0002102_abnormal_ear_morphology1.86905186
13MP0005174_abnormal_tail_pigmentation1.81795119
14MP0001293_anophthalmia1.80237977
15MP0001727_abnormal_embryo_implantation1.69392239
16MP0001346_abnormal_lacrimal_gland1.64105601
17MP0002277_abnormal_respiratory_mucosa1.63926055
18MP0003011_delayed_dark_adaptation1.59826881
19MP0008995_early_reproductive_senescence1.59231463
20MP0003938_abnormal_ear_development1.58723531
21MP0003315_abnormal_perineum_morphology1.57061012
22MP0000372_irregular_coat_pigmentation1.54283923
23MP0000631_abnormal_neuroendocrine_gland1.52184436
24MP0005499_abnormal_olfactory_system1.51297852
25MP0005394_taste/olfaction_phenotype1.51297852
26MP0004957_abnormal_blastocyst_morpholog1.50392504
27MP0001485_abnormal_pinna_reflex1.49874235
28MP0003880_abnormal_central_pattern1.49400169
29MP0002163_abnormal_gland_morphology1.47387840
30MP0002098_abnormal_vibrissa_morphology1.47283596
31MP0000762_abnormal_tongue_morphology1.46760936
32MP0001879_abnormal_lymphatic_vessel1.46592312
33MP0003693_abnormal_embryo_hatching1.43033995
34MP0008057_abnormal_DNA_replication1.42173765
35MP0005501_abnormal_skin_physiology1.40919219
36MP0003878_abnormal_ear_physiology1.38580376
37MP0005377_hearing/vestibular/ear_phenot1.38580376
38MP0004742_abnormal_vestibular_system1.34146785
39MP0005408_hypopigmentation1.34093471
40MP0003786_premature_aging1.30837578
41MP0000647_abnormal_sebaceous_gland1.30097823
42MP0000383_abnormal_hair_follicle1.29084106
43MP0002132_abnormal_respiratory_system1.28234406
44MP0002249_abnormal_larynx_morphology1.28038997
45MP0005423_abnormal_somatic_nervous1.25369602
46MP0003186_abnormal_redox_activity1.24940086
47MP0001905_abnormal_dopamine_level1.24342299
48MP0002095_abnormal_skin_pigmentation1.24239616
49MP0001851_eye_inflammation1.23788298
50MP0000026_abnormal_inner_ear1.23146791
51MP0003283_abnormal_digestive_organ1.22985515
52MP0002254_reproductive_system_inflammat1.22515911
53MP0005379_endocrine/exocrine_gland_phen1.21336909
54MP0009333_abnormal_splenocyte_physiolog1.20870422
55MP0008932_abnormal_embryonic_tissue1.19726558
56MP0006292_abnormal_olfactory_placode1.19582034
57MP0001286_abnormal_eye_development1.19460671
58MP0001853_heart_inflammation1.16567753
59MP0000049_abnormal_middle_ear1.15831451
60MP0005083_abnormal_biliary_tract1.15762618
61MP0003763_abnormal_thymus_physiology1.15630639
62MP0005084_abnormal_gallbladder_morpholo1.15412144
63MP0003724_increased_susceptibility_to1.13636428
64MP0005075_abnormal_melanosome_morpholog1.12135980
65MP0003122_maternal_imprinting1.12047474
66MP0002160_abnormal_reproductive_system1.11424681
67MP0001800_abnormal_humoral_immune1.10897573
68MP0002282_abnormal_trachea_morphology1.10730793
69MP0005000_abnormal_immune_tolerance1.09541886
70MP0003123_paternal_imprinting1.09292554
71MP0003718_maternal_effect1.08099441
72MP0000778_abnormal_nervous_system1.06644411
73MP0000465_gastrointestinal_hemorrhage1.05571313
74MP0001216_abnormal_epidermal_layer1.04993848
75MP0006072_abnormal_retinal_apoptosis1.04347489
76MP0001188_hyperpigmentation1.04289100
77MP0010771_integument_phenotype1.03003824
78MP0006276_abnormal_autonomic_nervous1.00179558
79MP0005389_reproductive_system_phenotype0.99281732
80MP0002822_catalepsy0.98669055
81MP0001919_abnormal_reproductive_system0.97590711
82MP0005671_abnormal_response_to0.97396525
83MP0002405_respiratory_system_inflammati0.97102478
84MP0000750_abnormal_muscle_regeneration0.95970496
85MP0005551_abnormal_eye_electrophysiolog0.95491162
86MP0005195_abnormal_posterior_eye0.95372343
87MP0003638_abnormal_response/metabolism_0.95043454
88MP0002060_abnormal_skin_morphology0.94562226
89MP0005025_abnormal_response_to0.94362936
90MP0001986_abnormal_taste_sensitivity0.93956868
91MP0003436_decreased_susceptibility_to0.92781733
92MP0001529_abnormal_vocalization0.92371565
93MP0002234_abnormal_pharynx_morphology0.92087201
94MP0002697_abnormal_eye_size0.91709504
95MP0002723_abnormal_immune_serum0.91619311
96MP0003077_abnormal_cell_cycle0.90583396
97MP0003806_abnormal_nucleotide_metabolis0.90203388
98MP0008058_abnormal_DNA_repair0.89951668
99MP0010678_abnormal_skin_adnexa0.89402681
100MP0004885_abnormal_endolymph0.88515165
101MP0002420_abnormal_adaptive_immunity0.87646933
102MP0003121_genomic_imprinting0.87433628
103MP0002452_abnormal_antigen_presenting0.86437429
104MP0002210_abnormal_sex_determination0.86407807
105MP0001835_abnormal_antigen_presentation0.86315324
106MP0002752_abnormal_somatic_nervous0.85408365
107MP0003787_abnormal_imprinting0.85296178
108MP0001819_abnormal_immune_cell0.85073454
109MP0001663_abnormal_digestive_system0.84658050
110MP0000703_abnormal_thymus_morphology0.84339019
111MP0002928_abnormal_bile_duct0.83183822
112MP0009053_abnormal_anal_canal0.82207747
113MP0000467_abnormal_esophagus_morphology0.81702922
114MP0009785_altered_susceptibility_to0.79364930
115MP0001873_stomach_inflammation0.78902498
116MP0004147_increased_porphyrin_level0.77755751
117MP0003890_abnormal_embryonic-extraembry0.76898900
118MP0000685_abnormal_immune_system0.76858203
119MP0002722_abnormal_immune_system0.76037467
120MP0000490_abnormal_crypts_of0.75867555
121MP0008875_abnormal_xenobiotic_pharmacok0.74602214
122MP0000377_abnormal_hair_follicle0.74301932
123MP0008877_abnormal_DNA_methylation0.73139914
124MP0001340_abnormal_eyelid_morphology0.70842042
125MP0005164_abnormal_response_to0.70679917
126MP0002736_abnormal_nociception_after0.70654585
127MP0004145_abnormal_muscle_electrophysio0.70323228
128MP0005391_vision/eye_phenotype0.69999537
129MP0001790_abnormal_immune_system0.69245132
130MP0005387_immune_system_phenotype0.69245132
131MP0001963_abnormal_hearing_physiology0.69155647
132MP0005381_digestive/alimentary_phenotyp0.68393201
133MP0001968_abnormal_touch/_nociception0.67832338
134MP0002751_abnormal_autonomic_nervous0.67821464
135MP0002233_abnormal_nose_morphology0.67554057
136MP0004142_abnormal_muscle_tone0.66709488
137MP0008872_abnormal_physiological_respon0.66454739
138MP0002009_preneoplasia0.66372782
139MP0001324_abnormal_eye_pigmentation0.66253434
140MP0002557_abnormal_social/conspecific_i0.66142516
141MP0005253_abnormal_eye_physiology0.65930803
142MP0002837_dystrophic_cardiac_calcinosis0.65893472
143MP0003453_abnormal_keratinocyte_physiol0.65774192
144MP0000537_abnormal_urethra_morphology0.65477328
145MP0010030_abnormal_orbit_morphology0.65438699
146MP0008789_abnormal_olfactory_epithelium0.64939949
147MP0009250_abnormal_appendicular_skeleto0.64869918
148MP0002166_altered_tumor_susceptibility0.64852850
149MP0002398_abnormal_bone_marrow0.64065529
150MP0003567_abnormal_fetal_cardiomyocyte0.64036967
151MP0005645_abnormal_hypothalamus_physiol0.63968021
152MP0000613_abnormal_salivary_gland0.63287885
153MP0000716_abnormal_immune_system0.63049069
154MP0005451_abnormal_body_composition0.63000643
155MP0000955_abnormal_spinal_cord0.62139637
156MP0002177_abnormal_outer_ear0.62084835
157MP0004133_heterotaxia0.61969228
158MP0009745_abnormal_behavioral_response0.61881325
159MP0002272_abnormal_nervous_system0.61492857
160MP0003119_abnormal_digestive_system0.61466136
161MP0002006_tumorigenesis0.61262602
162MP0002184_abnormal_innervation0.60913434

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)9.71638067
2* Macrocytic anemia (HP:0001972)7.17147015
3* Pallor (HP:0000980)6.18086944
4Abnormality of the axillary hair (HP:0100134)4.50469490
5Abnormality of secondary sexual hair (HP:0009888)4.50469490
6Congenital, generalized hypertrichosis (HP:0004540)4.15890578
7Increased hepatocellular lipid droplets (HP:0006565)4.04834127
8Acute necrotizing encephalopathy (HP:0006965)4.02965328
9Parakeratosis (HP:0001036)3.92220792
10Septo-optic dysplasia (HP:0100842)3.76202899
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.75085622
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.69205518
13Mitochondrial inheritance (HP:0001427)3.66509304
14Abnormal hemoglobin (HP:0011902)3.57667477
15Renal Fanconi syndrome (HP:0001994)3.46491780
16Progressive macrocephaly (HP:0004481)3.45147723
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.39494992
18Lipid accumulation in hepatocytes (HP:0006561)3.38040433
19Abnormal mitochondria in muscle tissue (HP:0008316)3.29839376
20Stenosis of the external auditory canal (HP:0000402)3.28056155
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09218290
22Exertional dyspnea (HP:0002875)3.08817978
23Woolly hair (HP:0002224)2.97231393
24Abnormality of reticulocytes (HP:0004312)2.91214478
25Acute encephalopathy (HP:0006846)2.90334805
26Congenital ichthyosiform erythroderma (HP:0007431)2.84835991
27* Depressed nasal ridge (HP:0000457)2.84572416
28Concave nail (HP:0001598)2.83743929
29Partial duplication of thumb phalanx (HP:0009944)2.83329401
303-Methylglutaconic aciduria (HP:0003535)2.79518383
31Increased CSF lactate (HP:0002490)2.74819348
32Asplenia (HP:0001746)2.74150345
33Respiratory difficulties (HP:0002880)2.70797538
34Partial duplication of the phalanx of hand (HP:0009999)2.68427773
35Hepatocellular necrosis (HP:0001404)2.63446092
36* Migraine (HP:0002076)2.62102674
37Maternal diabetes (HP:0009800)2.59591911
38Rib fusion (HP:0000902)2.53992744
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53034063
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53034063
41Aplastic anemia (HP:0001915)2.52818006
42Increased intramyocellular lipid droplets (HP:0012240)2.52347195
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.47021364
44Molar tooth sign on MRI (HP:0002419)2.44137201
45Abnormality of midbrain morphology (HP:0002418)2.44137201
46Absent thumb (HP:0009777)2.41970873
47Myokymia (HP:0002411)2.39964701
48Absent septum pellucidum (HP:0001331)2.39658869
49Pancreatic cysts (HP:0001737)2.39227711
5011 pairs of ribs (HP:0000878)2.37794468
51Hypotrichosis (HP:0001006)2.36525956
52Pancreatic fibrosis (HP:0100732)2.35834803
53Fragile nails (HP:0001808)2.29951191
54Optic disc pallor (HP:0000543)2.20266088
55* Thick lower lip vermilion (HP:0000179)2.19372541
56Hepatic necrosis (HP:0002605)2.15864675
57True hermaphroditism (HP:0010459)2.14673801
58Colon cancer (HP:0003003)2.14057548
59Aplasia cutis congenita (HP:0001057)2.12734405
60Abnormality of placental membranes (HP:0011409)2.09043647
61Amniotic constriction ring (HP:0009775)2.09043647
62Hypoplasia of the radius (HP:0002984)2.08794233
63Absent hand (HP:0004050)2.07946568
64Hypoproteinemia (HP:0003075)2.07817251
65Abnormality of renal resorption (HP:0011038)2.04385744
66Increased serum lactate (HP:0002151)2.01375966
67Triphalangeal thumb (HP:0001199)2.00245846
68Abnormality of cells of the erythroid lineage (HP:0012130)11.7376173
69Abnormal number of erythroid precursors (HP:0012131)10.4816078
70Oral leukoplakia (HP:0002745)1.99320000
71Trismus (HP:0000211)1.99191795
72Anophthalmia (HP:0000528)1.96754079
73Sclerocornea (HP:0000647)1.96249649
74Exercise intolerance (HP:0003546)1.94805767
75Thrombocytosis (HP:0001894)1.94054247
76Esophageal atresia (HP:0002032)1.93476742
77Increased muscle lipid content (HP:0009058)1.90502585
78Duplication of thumb phalanx (HP:0009942)1.88871597
79Nephronophthisis (HP:0000090)1.88637373
80Optic nerve hypoplasia (HP:0000609)1.88263729
81Congenital stationary night blindness (HP:0007642)1.88256590
82Mesangial abnormality (HP:0001966)1.85846263
83Seborrheic dermatitis (HP:0001051)1.85587157
84Erythroderma (HP:0001019)1.85118570
85Abnormal number of incisors (HP:0011064)1.85105994
86Respiratory failure (HP:0002878)1.83689040
87Multiple enchondromatosis (HP:0005701)1.78836416
88Sparse eyelashes (HP:0000653)1.77695782
89Leukodystrophy (HP:0002415)1.76329156
90Absent radius (HP:0003974)1.76302312
91Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75993330
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74542763
93Hyperglycinemia (HP:0002154)1.73001371
94Cleft eyelid (HP:0000625)1.72763791
95Abnormal ciliary motility (HP:0012262)1.72719133
96Absent hair (HP:0002298)1.72695120
97Bilateral microphthalmos (HP:0007633)1.72322674
98Lethargy (HP:0001254)1.72288897
99Abnormal respiratory motile cilium physiology (HP:0012261)1.70694695
100Abnormal rod and cone electroretinograms (HP:0008323)1.68554958
101Medial flaring of the eyebrow (HP:0010747)1.67995827
102Abnormal urine phosphate concentration (HP:0012599)1.67560319
103Nasolacrimal duct obstruction (HP:0000579)1.67345825
104Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67250577
105Cerebral edema (HP:0002181)1.67231871
106Pendular nystagmus (HP:0012043)1.66334631
107Forearm undergrowth (HP:0009821)1.65844941
108Anencephaly (HP:0002323)1.65538623
109Hypoplasia of the pons (HP:0012110)1.65397801
110Carpal bone hypoplasia (HP:0001498)1.64813682
111Absent forearm bone (HP:0003953)1.64781896
112Aplasia involving forearm bones (HP:0009822)1.64781896
113Conical tooth (HP:0000698)1.63701000
114Horseshoe kidney (HP:0000085)1.63407840
115Glossoptosis (HP:0000162)1.63144255
116Onycholysis (HP:0001806)1.62648000
117Pancytopenia (HP:0001876)1.62537304
118Aplasia/Hypoplasia of the ulna (HP:0006495)1.62511290
119Abnormal respiratory epithelium morphology (HP:0012253)1.62175717
120Abnormal respiratory motile cilium morphology (HP:0005938)1.62175717
121Type II lissencephaly (HP:0007260)1.60947933
122Sparse lateral eyebrow (HP:0005338)1.59595915
123Hypoplasia of the ulna (HP:0003022)1.59201487
124Type 2 muscle fiber atrophy (HP:0003554)1.57858601
125Aplasia/hypoplasia of the uterus (HP:0008684)1.56411812
126Abnormality of the parietal bone (HP:0002696)1.53818976
127Hyperphosphaturia (HP:0003109)1.52471735
128Abnormality of the septum pellucidum (HP:0007375)1.50129001
129Abnormal pupillary function (HP:0007686)1.50077606
130IgM deficiency (HP:0002850)1.49652887
131Panhypogammaglobulinemia (HP:0003139)1.49408606
132Neonatal respiratory distress (HP:0002643)1.48439921
133Plantar hyperkeratosis (HP:0007556)1.44176465
134Chin dimple (HP:0010751)1.43516212
135Ridged nail (HP:0001807)1.42777391
136Septate vagina (HP:0001153)1.42613732
137* Short nose (HP:0003196)1.42254547
138Breast hypoplasia (HP:0003187)1.40017479
139Abnormality of urine glucose concentration (HP:0011016)1.38587720
140Glycosuria (HP:0003076)1.38587720
141Lactic acidosis (HP:0003128)1.37311374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.50970095
2VRK24.88422555
3MST43.18334041
4TLK13.05561580
5LRRK22.97742166
6BUB12.93405318
7STK162.64168349
8CDC72.59260329
9RPS6KB22.48636379
10ZAK2.36458879
11BLK2.33797412
12VRK12.31565291
13WEE12.21650037
14SRPK12.18910937
15KDR2.12716557
16PIM21.71377536
17TGFBR11.67448932
18NME11.63680398
19MAP3K31.60125175
20BCKDK1.55771783
21CDK191.49399637
22BMPR1B1.45133528
23MAPKAPK51.45011097
24TXK1.44218358
25ILK1.40537760
26WNK41.38892211
27EEF2K1.34819019
28TAF11.32650150
29MAPKAPK31.30766294
30MAP3K111.28948730
31MAP4K11.26720054
32PBK1.19406152
33DYRK21.17945364
34GRK71.17742644
35DYRK31.16297279
36PKN11.13200969
37PNCK1.12947763
38UHMK11.12543615
39INSRR1.11867356
40TYRO31.09967201
41MAP2K21.07125221
42STK391.03036111
43MAPK151.02104462
44ADRBK11.01517412
45NEK21.00720467
46ARAF0.98667351
47WNK30.95346419
48EPHB20.94098712
49CLK10.93970276
50BTK0.93281277
51ADRBK20.92928653
52GRK10.91503909
53DAPK30.91458457
54MKNK10.89714462
55AURKB0.88696528
56NUAK10.88491335
57FES0.84994484
58AURKA0.82780958
59EIF2AK20.80637314
60TAOK30.80602692
61CASK0.79301950
62FGR0.79176200
63RPS6KA50.79064155
64CHEK20.78592272
65MUSK0.78410301
66TNIK0.77913646
67CSNK2A20.77554679
68MYLK0.77390866
69EIF2AK30.77280396
70IRAK20.76064208
71IKBKB0.75994722
72PRKCG0.73590760
73STK110.72992004
74RPS6KA60.72975690
75MST1R0.72041516
76TEC0.71444271
77MAPK40.71148515
78PIK3CA0.70224091
79SYK0.68445717
80ROCK20.67324234
81LYN0.66840769
82PASK0.66549902
83CDK70.66528140
84PTK60.63650193
85IRAK40.63528794
86ABL20.63243495
87STK100.63103620
88MAP2K70.62775869
89YES10.62320863
90CSNK2A10.62213885
91LCK0.61528557
92ITK0.61070245
93TIE10.59935044
94MAP3K120.59464383
95PAK10.59189190
96MOS0.56882561
97PRKCQ0.56740285
98IKBKE0.55041566
99PAK20.54519334
100NLK0.54460351
101BRAF0.53763172
102PIK3CG0.51958279
103MARK30.51880678
104RPS6KL10.51665897
105RPS6KC10.51665897
106MAPK130.50269317
107MAP3K100.49587380
108TGFBR20.47616161
109CAMKK10.47458506
110EPHA20.47047900
111FGFR20.46470472
112DYRK1B0.46018835
113CDK40.45424592
114ATR0.44971130
115PRKACA0.44819312
116PRKCD0.44533156
117MAPK120.44119108
118CAMK10.42527225
119CDK30.42064221
120BRSK20.41083241
121CDK80.41046235
122OXSR10.40015397
123KIT0.39973827
124GRK60.39428465
125TYK20.38771575
126PLK10.37432436
127NTRK20.36360577
128PLK40.36186542
129MAPKAPK20.35750686
130TESK20.35104820
131MAP2K30.34941068
132MAP3K90.34160737
133PINK10.33428931
134PIM10.33108678
135CSNK1E0.32592398
136STK240.32575168
137ACVR1B0.32285180
138PRKD10.32155042
139GRK50.32078058
140CAMKK20.30294989

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.06439640
2Parkinsons disease_Homo sapiens_hsa050123.47062665
3Proteasome_Homo sapiens_hsa030502.82819618
4RNA polymerase_Homo sapiens_hsa030202.82440278
5Alzheimers disease_Homo sapiens_hsa050102.66465899
6Huntingtons disease_Homo sapiens_hsa050162.60503361
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.38754391
8Spliceosome_Homo sapiens_hsa030402.30562170
9Protein export_Homo sapiens_hsa030602.24042887
10* Ribosome_Homo sapiens_hsa0301010.3142496
11DNA replication_Homo sapiens_hsa030301.85594108
12Mismatch repair_Homo sapiens_hsa034301.68174856
13Pyrimidine metabolism_Homo sapiens_hsa002401.61721254
14Cardiac muscle contraction_Homo sapiens_hsa042601.58292115
15Homologous recombination_Homo sapiens_hsa034401.39647260
16Nucleotide excision repair_Homo sapiens_hsa034201.37126900
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22740792
18Primary immunodeficiency_Homo sapiens_hsa053401.17672038
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14741640
20Arachidonic acid metabolism_Homo sapiens_hsa005901.05452387
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04886928
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.02183821
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98547048
24Non-homologous end-joining_Homo sapiens_hsa034500.96438375
25RNA transport_Homo sapiens_hsa030130.90537183
26RNA degradation_Homo sapiens_hsa030180.87533758
27Systemic lupus erythematosus_Homo sapiens_hsa053220.81713555
28Base excision repair_Homo sapiens_hsa034100.79342702
29Fanconi anemia pathway_Homo sapiens_hsa034600.79272091
30Graft-versus-host disease_Homo sapiens_hsa053320.78964872
31Basal transcription factors_Homo sapiens_hsa030220.77380812
32Folate biosynthesis_Homo sapiens_hsa007900.76817520
33Hematopoietic cell lineage_Homo sapiens_hsa046400.76347472
34Glutathione metabolism_Homo sapiens_hsa004800.72062713
35Asthma_Homo sapiens_hsa053100.69955655
36Purine metabolism_Homo sapiens_hsa002300.69858854
37Allograft rejection_Homo sapiens_hsa053300.69777654
38Vitamin digestion and absorption_Homo sapiens_hsa049770.69083260
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68396139
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68334561
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.67917069
42Autoimmune thyroid disease_Homo sapiens_hsa053200.67627670
43Linoleic acid metabolism_Homo sapiens_hsa005910.64289100
44Epstein-Barr virus infection_Homo sapiens_hsa051690.62202249
45Ether lipid metabolism_Homo sapiens_hsa005650.60997136
46Phototransduction_Homo sapiens_hsa047440.58912130
47Sphingolipid metabolism_Homo sapiens_hsa006000.58781493
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58206547
49p53 signaling pathway_Homo sapiens_hsa041150.54942284
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54041169
51One carbon pool by folate_Homo sapiens_hsa006700.52496974
52Basal cell carcinoma_Homo sapiens_hsa052170.51490827
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49474231
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49081886
55Nitrogen metabolism_Homo sapiens_hsa009100.47436600
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.47220808
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46372583
58Rheumatoid arthritis_Homo sapiens_hsa053230.46342539
59Hedgehog signaling pathway_Homo sapiens_hsa043400.45301016
60Fat digestion and absorption_Homo sapiens_hsa049750.44140956
61Fatty acid elongation_Homo sapiens_hsa000620.43829499
62Nicotine addiction_Homo sapiens_hsa050330.43378535
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42408224
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39289961
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39267743
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.37152944
67Cell cycle_Homo sapiens_hsa041100.36925244
68Tryptophan metabolism_Homo sapiens_hsa003800.36864174
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36587939
70Retinol metabolism_Homo sapiens_hsa008300.36126538
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36014960
72Sulfur relay system_Homo sapiens_hsa041220.35997044
73Peroxisome_Homo sapiens_hsa041460.35284844
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35241807
75Alcoholism_Homo sapiens_hsa050340.35062080
76Type I diabetes mellitus_Homo sapiens_hsa049400.34544303
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34041431
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32570002
79Caffeine metabolism_Homo sapiens_hsa002320.32205930
80Metabolic pathways_Homo sapiens_hsa011000.31742267
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31690773
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31140831
83Serotonergic synapse_Homo sapiens_hsa047260.30966030
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30673078
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30649325
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.30320730
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29948339
88Selenocompound metabolism_Homo sapiens_hsa004500.29355815
89T cell receptor signaling pathway_Homo sapiens_hsa046600.27972442
90Antigen processing and presentation_Homo sapiens_hsa046120.26566968
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26374186
92Malaria_Homo sapiens_hsa051440.26242628
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.25160588
94Pyruvate metabolism_Homo sapiens_hsa006200.25013547
95Pathways in cancer_Homo sapiens_hsa052000.23614587
96Herpes simplex infection_Homo sapiens_hsa051680.23032282
97Olfactory transduction_Homo sapiens_hsa047400.22601262
98Butanoate metabolism_Homo sapiens_hsa006500.21849691
99Collecting duct acid secretion_Homo sapiens_hsa049660.21810305
100HTLV-I infection_Homo sapiens_hsa051660.21705125
101Other glycan degradation_Homo sapiens_hsa005110.21624449
102Pertussis_Homo sapiens_hsa051330.21353709
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.21155386
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21147722
105Notch signaling pathway_Homo sapiens_hsa043300.20615171
106Sulfur metabolism_Homo sapiens_hsa009200.20145545
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18734312
108Tyrosine metabolism_Homo sapiens_hsa003500.16385875
109B cell receptor signaling pathway_Homo sapiens_hsa046620.16277974
110Chemical carcinogenesis_Homo sapiens_hsa052040.15774653
111Wnt signaling pathway_Homo sapiens_hsa043100.14906751
112Taste transduction_Homo sapiens_hsa047420.14827040
113Measles_Homo sapiens_hsa051620.14599163
114Chemokine signaling pathway_Homo sapiens_hsa040620.13930299
115Morphine addiction_Homo sapiens_hsa050320.13927088
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13615732
117Phagosome_Homo sapiens_hsa041450.13456756
118TGF-beta signaling pathway_Homo sapiens_hsa043500.13108432
119Axon guidance_Homo sapiens_hsa043600.12862902
120Phenylalanine metabolism_Homo sapiens_hsa003600.11456962
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.11394947
122Ras signaling pathway_Homo sapiens_hsa040140.10801887
123Small cell lung cancer_Homo sapiens_hsa052220.10599841
124Salmonella infection_Homo sapiens_hsa051320.10491839
125ECM-receptor interaction_Homo sapiens_hsa045120.10438443
126Mineral absorption_Homo sapiens_hsa049780.09656304
127mRNA surveillance pathway_Homo sapiens_hsa030150.09476066
128African trypanosomiasis_Homo sapiens_hsa051430.08969528
129Regulation of autophagy_Homo sapiens_hsa041400.08528419
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.06866504
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06323383
132Glycerolipid metabolism_Homo sapiens_hsa005610.05388852
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.04002919

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