RPS27AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.75177967
2ribosomal small subunit biogenesis (GO:0042274)6.61643447
3viral transcription (GO:0019083)6.16201336
4translational termination (GO:0006415)5.95183240
5maturation of SSU-rRNA (GO:0030490)5.78516683
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.38418824
7cotranslational protein targeting to membrane (GO:0006613)5.37881963
8protein targeting to ER (GO:0045047)5.32520805
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.16816749
10ATP synthesis coupled proton transport (GO:0015986)5.16816749
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.09974438
12protein localization to endoplasmic reticulum (GO:0070972)5.07227403
13translational elongation (GO:0006414)5.05845992
14DNA deamination (GO:0045006)4.95581893
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.74898289
16ribosomal large subunit biogenesis (GO:0042273)4.59713609
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56872550
18water-soluble vitamin biosynthetic process (GO:0042364)4.48921901
19viral life cycle (GO:0019058)4.47807787
20behavioral response to nicotine (GO:0035095)4.41533358
21cellular protein complex disassembly (GO:0043624)4.41337030
22chaperone-mediated protein transport (GO:0072321)4.35736499
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.26653401
24translational initiation (GO:0006413)4.18366848
25protein neddylation (GO:0045116)4.03701786
26protein complex biogenesis (GO:0070271)3.99331554
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97236850
28regulation of isotype switching to IgG isotypes (GO:0048302)3.91579120
29translation (GO:0006412)3.90671763
30regulation of immunoglobulin secretion (GO:0051023)3.86570996
31mitochondrial respiratory chain complex assembly (GO:0033108)3.84925545
32rRNA modification (GO:0000154)3.84074127
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.78696129
34ribonucleoprotein complex biogenesis (GO:0022613)3.76480892
35GTP biosynthetic process (GO:0006183)3.75227628
36protein complex disassembly (GO:0043241)3.70203335
37cellular component biogenesis (GO:0044085)3.67230808
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.64367596
39NADH dehydrogenase complex assembly (GO:0010257)3.64367596
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64367596
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59182485
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59182485
43parturition (GO:0007567)3.58343210
44rRNA methylation (GO:0031167)3.54712325
45protein targeting to membrane (GO:0006612)3.53254157
46macromolecular complex disassembly (GO:0032984)3.51992170
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51296548
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47181789
49electron transport chain (GO:0022900)3.46674332
50respiratory electron transport chain (GO:0022904)3.45086196
51rRNA metabolic process (GO:0016072)3.39448624
52rRNA processing (GO:0006364)3.39178963
53regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.35869819
54interferon-gamma production (GO:0032609)3.35244497
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.34953205
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30553224
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.23796794
58ATP biosynthetic process (GO:0006754)3.22234966
59UTP biosynthetic process (GO:0006228)3.13770658
60protein K6-linked ubiquitination (GO:0085020)3.10978242
61mRNA catabolic process (GO:0006402)3.05493621
62substrate-independent telencephalic tangential migration (GO:0021826)3.02866574
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.02866574
64termination of RNA polymerase III transcription (GO:0006386)3.02190703
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.02190703
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98188216
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94055671
68hydrogen ion transmembrane transport (GO:1902600)2.93623734
69respiratory chain complex IV assembly (GO:0008535)2.87696476
70CTP metabolic process (GO:0046036)2.86901434
71CTP biosynthetic process (GO:0006241)2.86901434
72intracellular protein transmembrane import (GO:0044743)2.86845091
73somite development (GO:0061053)2.83961216
74UTP metabolic process (GO:0046051)2.83377211
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82798375
76cytochrome complex assembly (GO:0017004)2.82300142
77nonmotile primary cilium assembly (GO:0035058)2.81426980
78cell proliferation in forebrain (GO:0021846)2.79322965
79proton transport (GO:0015992)2.76739389
80RNA catabolic process (GO:0006401)2.76695170
81regulation of cilium movement (GO:0003352)2.75564613
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74613117
83regulation of mitotic spindle checkpoint (GO:1903504)2.74613117
84ether lipid metabolic process (GO:0046485)2.73019719
85piRNA metabolic process (GO:0034587)2.72984609
86regulation of podosome assembly (GO:0071801)2.71733322
87termination of RNA polymerase I transcription (GO:0006363)2.69326316
88preassembly of GPI anchor in ER membrane (GO:0016254)2.69165052
89hydrogen transport (GO:0006818)2.68665593
90tRNA processing (GO:0008033)2.66753411
91synaptic transmission, cholinergic (GO:0007271)2.66508628
92pseudouridine synthesis (GO:0001522)2.66045155
93protein targeting to mitochondrion (GO:0006626)2.63932584
94positive regulation of defense response to virus by host (GO:0002230)2.61830448
95endoderm formation (GO:0001706)2.58850103
96establishment of protein localization to mitochondrion (GO:0072655)2.58632969
97positive regulation of T cell apoptotic process (GO:0070234)2.58123434
98dentate gyrus development (GO:0021542)2.55576706
99ncRNA processing (GO:0034470)2.54273423
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53393702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human5.00413897
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59400365
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.92015945
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.33323678
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95736283
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.90105860
7ZNF274_21170338_ChIP-Seq_K562_Hela2.60550326
8ELK1_19687146_ChIP-ChIP_HELA_Human2.51884809
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48510956
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.41353750
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.39805757
12VDR_23849224_ChIP-Seq_CD4+_Human2.33548674
13VDR_22108803_ChIP-Seq_LS180_Human2.25035321
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22432325
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09260639
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04051009
17EZH2_22144423_ChIP-Seq_EOC_Human2.03244325
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02815843
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93670337
20MYC_18940864_ChIP-ChIP_HL60_Human1.91993048
21FOXP3_21729870_ChIP-Seq_TREG_Human1.89803647
22TTF2_22483619_ChIP-Seq_HELA_Human1.89192568
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86111092
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85987361
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85651219
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.77755978
27EWS_26573619_Chip-Seq_HEK293_Human1.75283462
28GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.68836247
29TP53_22573176_ChIP-Seq_HFKS_Human1.64429959
30IRF1_19129219_ChIP-ChIP_H3396_Human1.63345283
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55808348
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54088162
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52875265
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.47177053
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46153755
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.45483237
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35026423
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32670546
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32297028
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31174118
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.31174118
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31087829
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30430659
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28411511
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28304580
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27888437
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24196496
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.23756726
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22818474
50NCOR_22424771_ChIP-Seq_293T_Human1.22296795
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21907595
52GABP_19822575_ChIP-Seq_HepG2_Human1.21783085
53FUS_26573619_Chip-Seq_HEK293_Human1.21061371
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.20219308
55XRN2_22483619_ChIP-Seq_HELA_Human1.18788696
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.18471359
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17367998
58ER_23166858_ChIP-Seq_MCF-7_Human1.16531141
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.14894124
60P300_19829295_ChIP-Seq_ESCs_Human1.13359314
61NANOG_20526341_ChIP-Seq_ESCs_Human1.13289685
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09343447
63NANOG_19829295_ChIP-Seq_ESCs_Human1.08215661
64SOX2_19829295_ChIP-Seq_ESCs_Human1.08215661
65DCP1A_22483619_ChIP-Seq_HELA_Human1.06845364
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03761416
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.03555532
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03048082
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02596924
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02555404
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02392467
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00234196
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00037751
74ERA_21632823_ChIP-Seq_H3396_Human0.99190773
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97850556
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95662658
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95310764
78HOXB7_26014856_ChIP-Seq_BT474_Human0.94907817
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.94714263
80REST_21632747_ChIP-Seq_MESCs_Mouse0.94438743
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94221556
82AR_20517297_ChIP-Seq_VCAP_Human0.94088587
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93770662
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93679224
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93671596
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.92950804
87TAF2_19829295_ChIP-Seq_ESCs_Human0.90713376
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90703578
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90196677
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.88271162
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87270040
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87256073
93PHF8_20622853_ChIP-Seq_HELA_Human0.87061333
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.85960641
95MYC_19829295_ChIP-Seq_ESCs_Human0.84750856
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84496700
97IGF1R_20145208_ChIP-Seq_DFB_Human0.83834031
98GATA3_21867929_ChIP-Seq_TH1_Mouse0.83820464
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83715745
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.82004405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.71522064
2MP0006292_abnormal_olfactory_placode4.20848547
3MP0008877_abnormal_DNA_methylation2.74541517
4MP0004142_abnormal_muscle_tone2.60198043
5MP0003787_abnormal_imprinting2.44432271
6MP0004147_increased_porphyrin_level2.44128473
7MP0001873_stomach_inflammation2.27812536
8MP0008789_abnormal_olfactory_epithelium2.27023012
9MP0006072_abnormal_retinal_apoptosis2.17999632
10MP0002837_dystrophic_cardiac_calcinosis2.15795914
11MP0004885_abnormal_endolymph2.15357346
12MP0008875_abnormal_xenobiotic_pharmacok2.08433755
13MP0002163_abnormal_gland_morphology2.04898082
14MP0001835_abnormal_antigen_presentation1.97682034
15MP0003786_premature_aging1.84921607
16MP0003646_muscle_fatigue1.80146311
17MP0002638_abnormal_pupillary_reflex1.75925246
18MP0005671_abnormal_response_to1.73737090
19MP0001485_abnormal_pinna_reflex1.71938755
20MP0001529_abnormal_vocalization1.70627018
21MP0005394_taste/olfaction_phenotype1.69781968
22MP0005499_abnormal_olfactory_system1.69781968
23MP0002938_white_spotting1.68764257
24MP0008872_abnormal_physiological_respon1.67544061
25MP0001293_anophthalmia1.66782081
26MP0004742_abnormal_vestibular_system1.58645255
27MP0002234_abnormal_pharynx_morphology1.58165576
28MP0005551_abnormal_eye_electrophysiolog1.57742445
29MP0006276_abnormal_autonomic_nervous1.49625075
30MP0002102_abnormal_ear_morphology1.48848764
31MP0003195_calcinosis1.44962278
32MP0002160_abnormal_reproductive_system1.43557062
33MP0003186_abnormal_redox_activity1.42612518
34MP0002272_abnormal_nervous_system1.41794312
35MP0000049_abnormal_middle_ear1.40609239
36MP0001968_abnormal_touch/_nociception1.39422450
37MP0005084_abnormal_gallbladder_morpholo1.38102600
38MP0004133_heterotaxia1.37042923
39MP0002736_abnormal_nociception_after1.35152111
40MP0005379_endocrine/exocrine_gland_phen1.30084997
41MP0001905_abnormal_dopamine_level1.25147382
42MP0001790_abnormal_immune_system1.25104050
43MP0005387_immune_system_phenotype1.25104050
44MP0006036_abnormal_mitochondrial_physio1.25073821
45MP0005389_reproductive_system_phenotype1.23586224
46MP0001348_abnormal_lacrimal_gland1.20986268
47MP0000685_abnormal_immune_system1.18475128
48MP0002876_abnormal_thyroid_physiology1.15878621
49MP0005646_abnormal_pituitary_gland1.15237526
50MP0000778_abnormal_nervous_system1.14410903
51MP0000631_abnormal_neuroendocrine_gland1.11473066
52MP0000372_irregular_coat_pigmentation1.11301809
53MP0009745_abnormal_behavioral_response1.09824599
54MP0002653_abnormal_ependyma_morphology1.09273645
55MP0000427_abnormal_hair_cycle1.08305941
56MP0003122_maternal_imprinting1.06353640
57MP0003121_genomic_imprinting1.06060113
58MP0004145_abnormal_muscle_electrophysio1.05560633
59MP0009046_muscle_twitch1.05431644
60MP0009333_abnormal_splenocyte_physiolog1.05221145
61MP0005645_abnormal_hypothalamus_physiol1.04773411
62MP0001984_abnormal_olfaction1.04090359
63MP0001440_abnormal_grooming_behavior1.03067558
64MP0005195_abnormal_posterior_eye1.00933763
65MP0002138_abnormal_hepatobiliary_system1.00440560
66MP0003011_delayed_dark_adaptation0.99459779
67MP0005253_abnormal_eye_physiology0.97347823
68MP0008995_early_reproductive_senescence0.96582192
69MP0001853_heart_inflammation0.94149877
70MP0009053_abnormal_anal_canal0.93176669
71MP0002277_abnormal_respiratory_mucosa0.92802535
72MP0008775_abnormal_heart_ventricle0.91251515
73MP0002693_abnormal_pancreas_physiology0.91154385
74MP0002557_abnormal_social/conspecific_i0.89453777
75MP0003718_maternal_effect0.89007052
76MP0001502_abnormal_circadian_rhythm0.88732882
77MP0001800_abnormal_humoral_immune0.88632133
78MP0001919_abnormal_reproductive_system0.88517350
79MP0002184_abnormal_innervation0.87207861
80MP0005075_abnormal_melanosome_morpholog0.86347140
81MP0003880_abnormal_central_pattern0.83623808
82MP0003693_abnormal_embryo_hatching0.83379230
83MP0000604_amyloidosis0.81505312
84MP0003806_abnormal_nucleotide_metabolis0.80264153
85MP0002148_abnormal_hypersensitivity_rea0.79166961
86MP0002752_abnormal_somatic_nervous0.78226756
87MP0003937_abnormal_limbs/digits/tail_de0.77009305
88MP0003567_abnormal_fetal_cardiomyocyte0.76486477
89MP0006035_abnormal_mitochondrial_morpho0.75658511
90MP0001663_abnormal_digestive_system0.75583075
91MP0000026_abnormal_inner_ear0.75458478
92MP0002572_abnormal_emotion/affect_behav0.75437857
93MP0001963_abnormal_hearing_physiology0.74679039
94MP0003123_paternal_imprinting0.73929044
95MP0002229_neurodegeneration0.73495281
96MP0005636_abnormal_mineral_homeostasis0.73145236
97MP0001542_abnormal_bone_strength0.72931465
98MP0001286_abnormal_eye_development0.71143966
99MP0003936_abnormal_reproductive_system0.70918777
100MP0001970_abnormal_pain_threshold0.70444884

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.94988181
2Acute necrotizing encephalopathy (HP:0006965)4.44727284
3Abnormality of cells of the erythroid lineage (HP:0012130)4.15437568
4Stomatitis (HP:0010280)3.89570900
5Acute encephalopathy (HP:0006846)3.80171803
6Abnormality of midbrain morphology (HP:0002418)3.75508674
7Molar tooth sign on MRI (HP:0002419)3.75508674
8Abnormal mitochondria in muscle tissue (HP:0008316)3.71003095
9Mitochondrial inheritance (HP:0001427)3.67407362
10Progressive macrocephaly (HP:0004481)3.64899908
11Increased CSF lactate (HP:0002490)3.48797736
12Congenital, generalized hypertrichosis (HP:0004540)3.48073450
13Increased hepatocellular lipid droplets (HP:0006565)3.30624558
14Macrocytic anemia (HP:0001972)3.25873390
15Abnormal number of erythroid precursors (HP:0012131)3.12944213
163-Methylglutaconic aciduria (HP:0003535)3.07416208
17Lipid accumulation in hepatocytes (HP:0006561)3.04609463
18Adrenal hypoplasia (HP:0000835)3.00904856
19Pancreatic cysts (HP:0001737)2.91021924
20Hepatocellular necrosis (HP:0001404)2.79230974
21Medial flaring of the eyebrow (HP:0010747)2.71041685
22Nephronophthisis (HP:0000090)2.68673849
23Congenital stationary night blindness (HP:0007642)2.68136830
24IgG deficiency (HP:0004315)2.65743666
25Abnormal rod and cone electroretinograms (HP:0008323)2.63488907
26Methylmalonic acidemia (HP:0002912)2.62635948
27Abnormality of the renal cortex (HP:0011035)2.61778977
28Renal Fanconi syndrome (HP:0001994)2.59898776
29Cerebral edema (HP:0002181)2.59750907
30Optic disc pallor (HP:0000543)2.58792513
31Absent thumb (HP:0009777)2.57136735
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55471306
33Pancreatic fibrosis (HP:0100732)2.55292451
34Submucous cleft hard palate (HP:0000176)2.54165590
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.48227776
36Pallor (HP:0000980)2.47133881
37Asplenia (HP:0001746)2.43989372
38Pendular nystagmus (HP:0012043)2.41978057
39True hermaphroditism (HP:0010459)2.41094320
40Hepatic necrosis (HP:0002605)2.39253325
41Colon cancer (HP:0003003)2.38700522
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37330526
43Type II lissencephaly (HP:0007260)2.35081853
44Abnormality of the renal medulla (HP:0100957)2.33206256
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32678184
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.32678184
47Abnormality of the pons (HP:0007361)2.29948102
48Increased serum lactate (HP:0002151)2.29361514
49Stenosis of the external auditory canal (HP:0000402)2.25871014
50Hypoplasia of the pons (HP:0012110)2.15672131
51Abnormal respiratory epithelium morphology (HP:0012253)2.12994875
52Abnormal respiratory motile cilium morphology (HP:0005938)2.12994875
53Abnormal biliary tract physiology (HP:0012439)2.09230480
54Bile duct proliferation (HP:0001408)2.09230480
55Gait imbalance (HP:0002141)2.09135176
56Methylmalonic aciduria (HP:0012120)2.06345506
57Septo-optic dysplasia (HP:0100842)2.05376029
58Exertional dyspnea (HP:0002875)2.04711773
59Congenital primary aphakia (HP:0007707)2.03753650
60Hyperglycinemia (HP:0002154)2.00628209
61Abnormality of renal resorption (HP:0011038)1.98918907
62Large for gestational age (HP:0001520)1.98635913
63Nephrogenic diabetes insipidus (HP:0009806)1.97795401
64Increased intramyocellular lipid droplets (HP:0012240)1.95967131
65Increased IgM level (HP:0003496)1.95195215
66Lactic acidosis (HP:0003128)1.94843887
67Absent/shortened dynein arms (HP:0200106)1.94637611
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.94637611
69Abnormal hair whorl (HP:0010721)1.92967125
70Rib fusion (HP:0000902)1.91810962
71Hypoplasia of the ulna (HP:0003022)1.89798243
72Depressed nasal ridge (HP:0000457)1.88246969
73Entropion (HP:0000621)1.87859203
74Constricted visual fields (HP:0001133)1.87824087
75Abnormality of the corticospinal tract (HP:0002492)1.86041630
76Renal cortical cysts (HP:0000803)1.85609509
77Hypochromic microcytic anemia (HP:0004840)1.85144881
78Leukodystrophy (HP:0002415)1.84109580
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83548958
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.83477512
81Hypoplasia of the fovea (HP:0007750)1.83477512
82Hyperalaninemia (HP:0003348)1.83045888
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83045888
84Abnormality of alanine metabolism (HP:0010916)1.83045888
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81616810
86Exercise intolerance (HP:0003546)1.80747434
87Type 2 muscle fiber atrophy (HP:0003554)1.79313268
88Abolished electroretinogram (ERG) (HP:0000550)1.79134243
89Narrow forehead (HP:0000341)1.79021999
90Hypoplasia of the radius (HP:0002984)1.78694414
91Elevated erythrocyte sedimentation rate (HP:0003565)1.78006529
92Aplasia/Hypoplasia of the ulna (HP:0006495)1.76651874
93Optic nerve hypoplasia (HP:0000609)1.75770834
94Abnormality of DNA repair (HP:0003254)1.75734964
95Forearm undergrowth (HP:0009821)1.75510056
96Respiratory failure (HP:0002878)1.75309152
97Abnormal ciliary motility (HP:0012262)1.75064835
98Shawl scrotum (HP:0000049)1.71833077
99Respiratory difficulties (HP:0002880)1.71324458
100Confusion (HP:0001289)1.70521341

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.10087080
2WNK43.06206568
3VRK22.64121698
4NME12.60764439
5NUAK12.57055435
6BMPR1B2.54477618
7MAP3K122.50660162
8ADRBK22.36349062
9MST42.04983722
10GRK12.04420890
11TSSK62.02713152
12MAP4K22.00328259
13PINK11.98934831
14EPHB21.97449635
15VRK11.72753918
16EIF2AK11.72303104
17WNK31.71035808
18ZAK1.64187951
19TLK11.63844499
20TAF11.58918037
21EIF2AK31.58836821
22FRK1.58704578
23STK391.51052919
24CAMKK21.48824522
25OXSR11.48653374
26PASK1.41190167
27MAP3K91.40736347
28NEK11.40446442
29TIE11.36970872
30PIK3CA1.33958521
31CDK191.30402135
32DYRK21.29812173
33PAK31.27979163
34TEC1.24814599
35PLK31.22144712
36PHKG21.10302032
37PHKG11.10302032
38PLK21.09272226
39MKNK21.08849102
40STK161.03341689
41CAMK10.95949489
42PRKCG0.94110857
43WNK10.92752329
44CSNK1G20.90920088
45MAP2K60.90137071
46TNIK0.84975970
47TAOK30.83842579
48IKBKB0.82754313
49CAMK1D0.77661053
50SRPK10.76087091
51GRK70.75666638
52PLK40.74389088
53ACVR1B0.73971244
54TYRO30.72449507
55EIF2AK20.72346158
56ITK0.72097585
57ADRBK10.71032971
58INSRR0.69381538
59CDC70.65108430
60CAMK1G0.64884356
61PBK0.64627808
62MYLK0.64337162
63MAP4K10.64330739
64CASK0.63759495
65PNCK0.63219298
66STK40.62471955
67MKNK10.61227500
68STK30.61043642
69CSNK2A20.60729641
70PRKCQ0.60709317
71ARAF0.60226005
72AURKB0.60067167
73MAP2K70.58656714
74BRAF0.56357194
75NTRK20.55984224
76PLK10.55971963
77PDK20.55836231
78PRKACA0.54173068
79PRKCI0.53977006
80MAP3K40.51107239
81MUSK0.50214999
82STK110.48898309
83DAPK30.48406609
84GRK50.47547104
85RPS6KA60.45488217
86CDK80.44805012
87IKBKE0.43319150
88CSNK1E0.42462652
89RPS6KA50.41294336
90CSNK1G30.40520944
91NME20.40022355
92CSNK2A10.38598210
93LRRK20.38504683
94TGFBR10.38049930
95MAPKAPK50.37842143
96CSNK1G10.37620288
97MARK30.37229530
98DMPK0.36831710
99PRKCH0.35794076
100PRKCA0.34611132

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.59286684
2Oxidative phosphorylation_Homo sapiens_hsa001904.07182839
3Proteasome_Homo sapiens_hsa030503.39494969
4Protein export_Homo sapiens_hsa030603.25676281
5Parkinsons disease_Homo sapiens_hsa050123.15853772
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52519792
7Basal transcription factors_Homo sapiens_hsa030222.40973108
8RNA polymerase_Homo sapiens_hsa030202.39215875
9Huntingtons disease_Homo sapiens_hsa050162.26548557
10Alzheimers disease_Homo sapiens_hsa050102.19360536
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14665570
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04419197
13Asthma_Homo sapiens_hsa053102.02998305
14Cardiac muscle contraction_Homo sapiens_hsa042601.94380430
15Homologous recombination_Homo sapiens_hsa034401.90496022
16RNA degradation_Homo sapiens_hsa030181.88785036
17Allograft rejection_Homo sapiens_hsa053301.79668599
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75966735
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.74849842
20Linoleic acid metabolism_Homo sapiens_hsa005911.60522094
21Autoimmune thyroid disease_Homo sapiens_hsa053201.58347139
22One carbon pool by folate_Homo sapiens_hsa006701.54797483
23Nucleotide excision repair_Homo sapiens_hsa034201.53970705
24Phototransduction_Homo sapiens_hsa047441.50627661
25Collecting duct acid secretion_Homo sapiens_hsa049661.34269491
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33718811
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23432687
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22860567
29Peroxisome_Homo sapiens_hsa041461.20668840
30Primary immunodeficiency_Homo sapiens_hsa053401.18957587
31Fanconi anemia pathway_Homo sapiens_hsa034601.17752448
32Pyrimidine metabolism_Homo sapiens_hsa002401.16806295
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13998669
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.13906235
35Mismatch repair_Homo sapiens_hsa034301.13086393
36Vitamin B6 metabolism_Homo sapiens_hsa007501.08790802
37Spliceosome_Homo sapiens_hsa030401.06765062
38Caffeine metabolism_Homo sapiens_hsa002321.02597524
39Regulation of autophagy_Homo sapiens_hsa041401.02185017
40Propanoate metabolism_Homo sapiens_hsa006401.00742523
41RNA transport_Homo sapiens_hsa030130.99706566
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98155131
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95161785
44Type I diabetes mellitus_Homo sapiens_hsa049400.92805279
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91057318
46Folate biosynthesis_Homo sapiens_hsa007900.89552798
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88449474
48Ether lipid metabolism_Homo sapiens_hsa005650.87996053
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86112395
50Butanoate metabolism_Homo sapiens_hsa006500.85779703
51Tryptophan metabolism_Homo sapiens_hsa003800.83139743
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82920753
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82569336
54Purine metabolism_Homo sapiens_hsa002300.78924571
55Arachidonic acid metabolism_Homo sapiens_hsa005900.73740364
56Nicotine addiction_Homo sapiens_hsa050330.73650926
57Rheumatoid arthritis_Homo sapiens_hsa053230.73215867
58Retinol metabolism_Homo sapiens_hsa008300.68387238
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67066589
60Nitrogen metabolism_Homo sapiens_hsa009100.66768001
61Graft-versus-host disease_Homo sapiens_hsa053320.66684195
62Chemical carcinogenesis_Homo sapiens_hsa052040.66247736
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.63899762
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63895918
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63486020
66Metabolic pathways_Homo sapiens_hsa011000.62619094
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57927935
68Fatty acid elongation_Homo sapiens_hsa000620.57083046
69Mineral absorption_Homo sapiens_hsa049780.56821300
70Steroid biosynthesis_Homo sapiens_hsa001000.55557936
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53146607
72DNA replication_Homo sapiens_hsa030300.52825509
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52820875
74Sulfur metabolism_Homo sapiens_hsa009200.52146693
75Hematopoietic cell lineage_Homo sapiens_hsa046400.50024855
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49405244
77Non-homologous end-joining_Homo sapiens_hsa034500.49371596
78T cell receptor signaling pathway_Homo sapiens_hsa046600.48615049
79Fat digestion and absorption_Homo sapiens_hsa049750.46650963
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42538298
81Selenocompound metabolism_Homo sapiens_hsa004500.39714596
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.39092893
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38332740
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.38250136
85Insulin secretion_Homo sapiens_hsa049110.38146626
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.35661567
87Olfactory transduction_Homo sapiens_hsa047400.33164322
88Pyruvate metabolism_Homo sapiens_hsa006200.29917916
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.29862667
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.27187180
91Ovarian steroidogenesis_Homo sapiens_hsa049130.26272052
92Morphine addiction_Homo sapiens_hsa050320.26020436
93Serotonergic synapse_Homo sapiens_hsa047260.24812300
94Basal cell carcinoma_Homo sapiens_hsa052170.24251077
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23542830
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23213610
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20936590
98Glycerolipid metabolism_Homo sapiens_hsa005610.20422812
99p53 signaling pathway_Homo sapiens_hsa041150.16910740
100Fatty acid degradation_Homo sapiens_hsa000710.15787728

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