RPS27AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.27879018
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.90680910
3DNA deamination (GO:0045006)5.88330372
4ATP synthesis coupled proton transport (GO:0015986)5.80492895
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80492895
6viral transcription (GO:0019083)5.59340213
7translational termination (GO:0006415)5.39859126
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97219696
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.92970758
10cytidine deamination (GO:0009972)4.90567732
11cytidine metabolic process (GO:0046087)4.90567732
12cytidine catabolic process (GO:0006216)4.90567732
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.85743284
14protein neddylation (GO:0045116)4.81967934
15protein targeting to ER (GO:0045047)4.79003614
16cotranslational protein targeting to membrane (GO:0006613)4.78957198
17respiratory electron transport chain (GO:0022904)4.73743325
18electron transport chain (GO:0022900)4.73204818
19translational elongation (GO:0006414)4.68779195
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.56649638
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55448357
22protein localization to endoplasmic reticulum (GO:0070972)4.51537229
23maturation of SSU-rRNA (GO:0030490)4.43079233
24ribosomal small subunit biogenesis (GO:0042274)4.33595324
25cellular protein complex disassembly (GO:0043624)4.03235063
26pyrimidine ribonucleoside catabolic process (GO:0046133)4.01088091
27viral life cycle (GO:0019058)3.99187174
28protein complex biogenesis (GO:0070271)3.90544785
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.78660660
30ribosomal large subunit biogenesis (GO:0042273)3.66011736
31water-soluble vitamin biosynthetic process (GO:0042364)3.58430240
32behavioral response to nicotine (GO:0035095)3.56769345
33translational initiation (GO:0006413)3.54378578
34chaperone-mediated protein transport (GO:0072321)3.48125875
35hydrogen ion transmembrane transport (GO:1902600)3.43105083
36mitochondrial respiratory chain complex assembly (GO:0033108)3.38666216
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.37993426
38NADH dehydrogenase complex assembly (GO:0010257)3.37993426
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37993426
40sequestering of actin monomers (GO:0042989)3.37462951
41mannosylation (GO:0097502)3.32556341
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27884483
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27884483
44translation (GO:0006412)3.27231092
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25843309
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24207992
47ATP biosynthetic process (GO:0006754)3.23549965
48proton transport (GO:0015992)3.22975872
49protein complex disassembly (GO:0043241)3.20739134
50hydrogen transport (GO:0006818)3.17176489
51kynurenine metabolic process (GO:0070189)3.12786411
52protein targeting to membrane (GO:0006612)3.10304793
53macromolecular complex disassembly (GO:0032984)3.08969638
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05195616
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.04963929
56indole-containing compound catabolic process (GO:0042436)3.04075729
57indolalkylamine catabolic process (GO:0046218)3.04075729
58tryptophan catabolic process (GO:0006569)3.04075729
59positive T cell selection (GO:0043368)3.02901004
60proteasome assembly (GO:0043248)2.94965496
61cytochrome complex assembly (GO:0017004)2.91162067
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.88408084
63termination of RNA polymerase III transcription (GO:0006386)2.88408084
64positive regulation of calcium-mediated signaling (GO:0050850)2.86341251
65nuclear-transcribed mRNA catabolic process (GO:0000956)2.81312263
66positive thymic T cell selection (GO:0045059)2.76949788
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73380552
68protein-cofactor linkage (GO:0018065)2.70804435
69tryptophan metabolic process (GO:0006568)2.70361792
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69540931
71preassembly of GPI anchor in ER membrane (GO:0016254)2.69483060
72regulation of cellular amino acid metabolic process (GO:0006521)2.68653816
73indolalkylamine metabolic process (GO:0006586)2.68524400
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67959194
75respiratory chain complex IV assembly (GO:0008535)2.67345077
76mRNA catabolic process (GO:0006402)2.65947479
77response to interferon-beta (GO:0035456)2.64645473
78negative T cell selection (GO:0043383)2.64198339
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62632618
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62632618
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62632618
82base-excision repair, AP site formation (GO:0006285)2.61353941
83sulfation (GO:0051923)2.60778092
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60720317
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60720317
86GPI anchor metabolic process (GO:0006505)2.60421577
87positive regulation of tolerance induction (GO:0002645)2.60089760
88metallo-sulfur cluster assembly (GO:0031163)2.59996755
89iron-sulfur cluster assembly (GO:0016226)2.59996755
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59542429
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56640614
92GPI anchor biosynthetic process (GO:0006506)2.54977423
93cellular component biogenesis (GO:0044085)2.54617335
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54596935
95mast cell activation (GO:0045576)2.51716847
96T cell migration (GO:0072678)2.51234934
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.50279794
98negative regulation of mast cell activation (GO:0033004)2.50011138
99cell wall macromolecule metabolic process (GO:0044036)2.49018729
100positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48227688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.46144992
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.32352994
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.08207767
4VDR_22108803_ChIP-Seq_LS180_Human2.87348486
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.71198825
6ZNF274_21170338_ChIP-Seq_K562_Hela2.66791550
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58806685
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47747368
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.47097659
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26835674
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.18239715
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15533412
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13499936
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05747362
15VDR_23849224_ChIP-Seq_CD4+_Human2.00659546
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.98983561
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95108776
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94006903
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89842534
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88740451
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.83398902
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82294004
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77067616
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72406716
25IGF1R_20145208_ChIP-Seq_DFB_Human1.71532196
26MYC_18940864_ChIP-ChIP_HL60_Human1.67441460
27ELK1_19687146_ChIP-ChIP_HELA_Human1.64514371
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64316926
29EWS_26573619_Chip-Seq_HEK293_Human1.60952245
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59079984
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58354379
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57307319
33TP53_22573176_ChIP-Seq_HFKS_Human1.56881411
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55528647
35FUS_26573619_Chip-Seq_HEK293_Human1.51661924
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50260571
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.50260571
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.49109908
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48571772
40FOXP3_21729870_ChIP-Seq_TREG_Human1.47872021
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46187260
42ER_23166858_ChIP-Seq_MCF-7_Human1.43349187
43AR_20517297_ChIP-Seq_VCAP_Human1.43053468
44TAF15_26573619_Chip-Seq_HEK293_Human1.42899592
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42898254
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39525354
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37865156
48P300_19829295_ChIP-Seq_ESCs_Human1.37710178
49IRF1_19129219_ChIP-ChIP_H3396_Human1.36236706
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36169458
51NANOG_20526341_ChIP-Seq_ESCs_Human1.34156152
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33595626
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31657036
54HTT_18923047_ChIP-ChIP_STHdh_Human1.29017159
55GATA3_26560356_Chip-Seq_TH2_Human1.28852181
56NCOR_22424771_ChIP-Seq_293T_Human1.28601693
57SOX2_19829295_ChIP-Seq_ESCs_Human1.26964653
58NANOG_19829295_ChIP-Seq_ESCs_Human1.26964653
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26280654
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25590596
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.22530295
62TAF2_19829295_ChIP-Seq_ESCs_Human1.20768723
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20373107
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16135053
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15487802
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14990140
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14294062
68GBX2_23144817_ChIP-Seq_PC3_Human1.13734502
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13667006
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.13587845
71BCAT_22108803_ChIP-Seq_LS180_Human1.13542010
72MYB_26560356_Chip-Seq_TH2_Human1.13514905
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.12816650
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12771004
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11186328
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11086310
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.10577151
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10507736
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10374162
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09859096
81CBP_20019798_ChIP-Seq_JUKART_Human1.09859096
82MYC_19829295_ChIP-Seq_ESCs_Human1.08693623
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08555436
84RBPJ_21746931_ChIP-Seq_IB4_Human1.07981994
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.07977619
86GATA3_27048872_Chip-Seq_THYMUS_Human1.07759468
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07609382
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05899302
89RUNX_20019798_ChIP-Seq_JUKART_Human1.05813358
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.05574496
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.04568031
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03741820
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02516664
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01455527
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99924181
96ERG_20517297_ChIP-Seq_VCAP_Human0.99879703
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99605961
98PHF8_20622853_ChIP-Seq_HELA_Human0.98821640
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97554336
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96994032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.43087515
2MP0005671_abnormal_response_to4.01320896
3MP0003646_muscle_fatigue2.44586289
4MP0002102_abnormal_ear_morphology2.36911792
5MP0000372_irregular_coat_pigmentation2.26191813
6MP0002653_abnormal_ependyma_morphology2.22002996
7MP0008877_abnormal_DNA_methylation2.21586408
8MP0001835_abnormal_antigen_presentation2.19842027
9MP0002163_abnormal_gland_morphology2.19700948
10MP0006072_abnormal_retinal_apoptosis2.17592012
11MP0006292_abnormal_olfactory_placode2.10054485
12MP0002837_dystrophic_cardiac_calcinosis2.06997643
13MP0008872_abnormal_physiological_respon2.01211128
14MP0005646_abnormal_pituitary_gland1.96364257
15MP0001873_stomach_inflammation1.96196734
16MP0009785_altered_susceptibility_to1.95311798
17MP0005377_hearing/vestibular/ear_phenot1.90048493
18MP0003878_abnormal_ear_physiology1.90048493
19MP0004142_abnormal_muscle_tone1.77670925
20MP0003880_abnormal_central_pattern1.76948602
21MP0002736_abnormal_nociception_after1.66740028
22MP0002277_abnormal_respiratory_mucosa1.61673025
23MP0003806_abnormal_nucleotide_metabolis1.59936151
24MP0005551_abnormal_eye_electrophysiolog1.58184544
25MP0003195_calcinosis1.57877978
26MP0002095_abnormal_skin_pigmentation1.55607438
27MP0002166_altered_tumor_susceptibility1.47138197
28MP0005645_abnormal_hypothalamus_physiol1.45028218
29MP0001968_abnormal_touch/_nociception1.43798143
30MP0001800_abnormal_humoral_immune1.43769673
31MP0005075_abnormal_melanosome_morpholog1.42232569
32MP0001905_abnormal_dopamine_level1.41761874
33MP0003763_abnormal_thymus_physiology1.40348359
34MP0004145_abnormal_muscle_electrophysio1.37189487
35MP0003011_delayed_dark_adaptation1.36907406
36MP0005379_endocrine/exocrine_gland_phen1.36833270
37MP0005174_abnormal_tail_pigmentation1.36480902
38MP0000685_abnormal_immune_system1.34593571
39MP0002876_abnormal_thyroid_physiology1.34453425
40MP0002148_abnormal_hypersensitivity_rea1.34324046
41MP0004885_abnormal_endolymph1.32393356
42MP0008875_abnormal_xenobiotic_pharmacok1.30988460
43MP0005000_abnormal_immune_tolerance1.26220339
44MP0003136_yellow_coat_color1.25699574
45MP0001790_abnormal_immune_system1.23985029
46MP0005387_immune_system_phenotype1.23985029
47MP0001485_abnormal_pinna_reflex1.20997898
48MP0008995_early_reproductive_senescence1.20857051
49MP0004147_increased_porphyrin_level1.20854507
50MP0002160_abnormal_reproductive_system1.20586217
51MP0006036_abnormal_mitochondrial_physio1.20409776
52MP0003787_abnormal_imprinting1.17735873
53MP0002638_abnormal_pupillary_reflex1.17184419
54MP0002420_abnormal_adaptive_immunity1.17082048
55MP0001819_abnormal_immune_cell1.15463594
56MP0005253_abnormal_eye_physiology1.15375549
57MP0005389_reproductive_system_phenotype1.14605867
58MP0005025_abnormal_response_to1.13227553
59MP0002723_abnormal_immune_serum1.13183025
60MP0002272_abnormal_nervous_system1.13060886
61MP0002006_tumorigenesis1.10981398
62MP0010386_abnormal_urinary_bladder1.08885460
63MP0004742_abnormal_vestibular_system1.07201715
64MP0002938_white_spotting1.06479247
65MP0009764_decreased_sensitivity_to1.06019195
66MP0009333_abnormal_splenocyte_physiolog1.05709655
67MP0006276_abnormal_autonomic_nervous1.05193063
68MP0001919_abnormal_reproductive_system1.02042219
69MP0002138_abnormal_hepatobiliary_system1.01229196
70MP0005084_abnormal_gallbladder_morpholo1.00740695
71MP0009745_abnormal_behavioral_response0.97364119
72MP0000631_abnormal_neuroendocrine_gland0.97055267
73MP0000716_abnormal_immune_system0.96602942
74MP0002452_abnormal_antigen_presenting0.96540549
75MP0003866_abnormal_defecation0.96154911
76MP0005410_abnormal_fertilization0.95907471
77MP0001501_abnormal_sleep_pattern0.94576663
78MP0002693_abnormal_pancreas_physiology0.89393849
79MP0001440_abnormal_grooming_behavior0.86975160
80MP0002928_abnormal_bile_duct0.86877993
81MP0009046_muscle_twitch0.85581605
82MP0002398_abnormal_bone_marrow0.84371703
83MP0001970_abnormal_pain_threshold0.83892136
84MP0003252_abnormal_bile_duct0.83275347
85MP0001663_abnormal_digestive_system0.81943101
86MP0001765_abnormal_ion_homeostasis0.81905337
87MP0001986_abnormal_taste_sensitivity0.79924648
88MP0005636_abnormal_mineral_homeostasis0.79434697
89MP0003567_abnormal_fetal_cardiomyocyte0.78879514
90MP0003638_abnormal_response/metabolism_0.75865791
91MP0003137_abnormal_impulse_conducting0.74281512
92MP0000026_abnormal_inner_ear0.73835601
93MP0001845_abnormal_inflammatory_respons0.73383654
94MP0002132_abnormal_respiratory_system0.73087706
95MP0003283_abnormal_digestive_organ0.72206395
96MP0001188_hyperpigmentation0.71163103
97MP0004019_abnormal_vitamin_homeostasis0.69002709
98MP0006082_CNS_inflammation0.67870138
99MP0001764_abnormal_homeostasis0.66830682
100MP0002429_abnormal_blood_cell0.66600640

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.12366580
2Abnormal mitochondria in muscle tissue (HP:0008316)4.53987805
3Mitochondrial inheritance (HP:0001427)4.53675844
4Progressive macrocephaly (HP:0004481)4.31973186
5Acute encephalopathy (HP:0006846)4.22547726
6Hepatocellular necrosis (HP:0001404)3.97479522
7Increased CSF lactate (HP:0002490)3.91763172
83-Methylglutaconic aciduria (HP:0003535)3.71438121
9Aplastic anemia (HP:0001915)3.65710216
10Congenital stationary night blindness (HP:0007642)3.55216846
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.52814471
12Reticulocytopenia (HP:0001896)3.52010944
13Increased hepatocellular lipid droplets (HP:0006565)3.49014540
14Abnormality of cells of the erythroid lineage (HP:0012130)3.39784245
15Hepatic necrosis (HP:0002605)3.37752604
16Molar tooth sign on MRI (HP:0002419)3.31320672
17Abnormality of midbrain morphology (HP:0002418)3.31320672
18Pancreatic cysts (HP:0001737)3.28746610
19Lipid accumulation in hepatocytes (HP:0006561)3.21697273
20Pancreatic fibrosis (HP:0100732)3.10895903
21Cerebral edema (HP:0002181)3.09116348
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05957087
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05957087
24Optic disc pallor (HP:0000543)3.01656106
25True hermaphroditism (HP:0010459)3.00875983
26Macrocytic anemia (HP:0001972)2.98272892
27Increased intramyocellular lipid droplets (HP:0012240)2.97956030
28Renal Fanconi syndrome (HP:0001994)2.91917490
29IgG deficiency (HP:0004315)2.91546721
30Abnormal rod and cone electroretinograms (HP:0008323)2.91033456
31Elevated erythrocyte sedimentation rate (HP:0003565)2.79917908
32Abnormal number of erythroid precursors (HP:0012131)2.76037840
33Leukodystrophy (HP:0002415)2.72288720
34Congenital, generalized hypertrichosis (HP:0004540)2.59270892
35Pallor (HP:0000980)2.59139053
36T lymphocytopenia (HP:0005403)2.55637996
37Nephronophthisis (HP:0000090)2.55503417
38Abnormality of T cell number (HP:0011839)2.55250214
39Abnormality of B cell number (HP:0010975)2.54147451
40Increased IgM level (HP:0003496)2.52504259
41Increased muscle lipid content (HP:0009058)2.47398630
42Severe combined immunodeficiency (HP:0004430)2.46965927
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45614283
44Abolished electroretinogram (ERG) (HP:0000550)2.42700777
45Abnormality of T cells (HP:0002843)2.40273278
46Exertional dyspnea (HP:0002875)2.39726597
47Type II lissencephaly (HP:0007260)2.39512774
48Respiratory failure (HP:0002878)2.38790456
49Hypoproteinemia (HP:0003075)2.36625619
50Attenuation of retinal blood vessels (HP:0007843)2.31531335
51Stomatitis (HP:0010280)2.29760479
52Increased serum lactate (HP:0002151)2.28958393
53Methylmalonic acidemia (HP:0002912)2.27249849
54Abnormality of renal resorption (HP:0011038)2.27036377
55Lactic acidosis (HP:0003128)2.24842696
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20126561
57Stenosis of the external auditory canal (HP:0000402)2.19632863
58Colon cancer (HP:0003003)2.18071649
59Absent thumb (HP:0009777)2.17259176
60Abnormality of the renal cortex (HP:0011035)2.16272822
61Medial flaring of the eyebrow (HP:0010747)2.12030801
62Abnormal hemoglobin (HP:0011902)2.09814370
63Global brain atrophy (HP:0002283)2.07802795
64Decreased central vision (HP:0007663)2.05831940
65B lymphocytopenia (HP:0010976)2.03933375
66Sclerocornea (HP:0000647)2.03129752
67Panhypogammaglobulinemia (HP:0003139)2.02031305
68Lethargy (HP:0001254)2.01966222
69Abnormality of the renal medulla (HP:0100957)1.97984693
70Autoimmune hemolytic anemia (HP:0001890)1.92487263
71Respiratory difficulties (HP:0002880)1.92114477
72Methylmalonic aciduria (HP:0012120)1.91788418
73Constricted visual fields (HP:0001133)1.91198963
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90620465
75Cystic liver disease (HP:0006706)1.89201851
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.88813708
77Pancytopenia (HP:0001876)1.87891789
78Thyroiditis (HP:0100646)1.85532334
79Exercise intolerance (HP:0003546)1.85358807
80Polydipsia (HP:0001959)1.84410878
81Abnormal drinking behavior (HP:0030082)1.84410878
82Pendular nystagmus (HP:0012043)1.84239764
83Combined immunodeficiency (HP:0005387)1.83877729
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.82457124
85Male pseudohermaphroditism (HP:0000037)1.79696466
86Abnormality of T cell physiology (HP:0011840)1.78692088
87Hypoplasia of the ulna (HP:0003022)1.77257592
88Renal cortical cysts (HP:0000803)1.76920839
89Hyperglycinemia (HP:0002154)1.76905508
90Aplasia/hypoplasia of the uterus (HP:0008684)1.76427918
91Asplenia (HP:0001746)1.74624532
92Hyperphosphaturia (HP:0003109)1.74481482
93Severe visual impairment (HP:0001141)1.72318024
94Encephalitis (HP:0002383)1.72242604
95Abnormality of urine glucose concentration (HP:0011016)1.68189955
96Glycosuria (HP:0003076)1.68189955
97Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68137458
98Hypoplasia of the uterus (HP:0000013)1.67945097
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67629984
100Polyuria (HP:0000103)1.66138567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.50748899
2MAP4K23.62769824
3CDK193.25315524
4KDR2.98483776
5ADRBK22.71061269
6PINK12.67788301
7MAP3K122.49837786
8VRK22.36692946
9MAP4K12.35394130
10TAOK32.33037750
11ZAK2.31286822
12GRK12.29240972
13TESK22.26576410
14WNK42.09398728
15PASK1.91435625
16FRK1.79290122
17TLK11.77533707
18BCKDK1.65107871
19NUAK11.59048945
20ITK1.51242484
21OXSR11.49244202
22MUSK1.44471060
23VRK11.34479913
24TEC1.30601972
25STK161.30408103
26CDC71.21633324
27NLK1.19836744
28WNK31.19500597
29MST41.19325291
30STK391.18547495
31MAP3K111.12066564
32DYRK21.11446874
33CDK31.07552664
34MYLK1.05956269
35TRIM281.05585671
36PRKCQ1.02177535
37SYK1.02122076
38SCYL21.01439700
39MAP2K60.97294810
40INSRR0.92356831
41GRK70.86441028
42IKBKB0.85093270
43RPS6KA40.83257634
44NME10.82597457
45LYN0.82309249
46OBSCN0.80225622
47RPS6KA50.77435350
48MAPK130.76997204
49IKBKE0.76824341
50IRAK40.76569832
51PIK3CA0.76534705
52FES0.72818033
53LCK0.72803770
54BTK0.69570397
55DAPK10.69066279
56PLK40.67372214
57BMPR1B0.66345870
58ADRBK10.66183093
59CSF1R0.65774963
60TIE10.65669558
61CAMKK20.65243453
62EIF2AK30.64425609
63KIT0.63549488
64LIMK10.62928065
65CSNK1G10.60232015
66GRK60.60017852
67TNK20.58976518
68DAPK30.58346281
69PLK20.54906689
70DAPK20.53743857
71ERBB30.53022358
72PIM10.52897244
73MAPKAPK30.51787630
74NTRK30.51646942
75PRKACA0.49536013
76CAMK10.49514528
77LRRK20.49259755
78CSNK2A10.47908368
79CSK0.47305724
80CSNK2A20.46623179
81TAF10.46515541
82IGF1R0.46494012
83CAMKK10.45721666
84DYRK1A0.44199523
85PRKCA0.42240311
86CAMK2A0.39391777
87CSNK1A10.37684496
88GRK50.34526653
89PRKCG0.34520343
90MAPK150.34349690
91ZAP700.31968051
92CHEK20.30300712
93PTK2B0.29469369
94PRKG10.29182302
95ILK0.28141923
96AURKA0.27948942
97PRKCE0.27908700
98PIK3CG0.27791233
99DYRK1B0.27508167
100PHKG20.27095617

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.57983527
2Oxidative phosphorylation_Homo sapiens_hsa001904.41138429
3Parkinsons disease_Homo sapiens_hsa050123.55484077
4Proteasome_Homo sapiens_hsa030503.44729798
5Primary immunodeficiency_Homo sapiens_hsa053403.36761079
6Alzheimers disease_Homo sapiens_hsa050102.47139340
7Huntingtons disease_Homo sapiens_hsa050162.35490109
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29394952
9Protein export_Homo sapiens_hsa030602.28709890
10Cardiac muscle contraction_Homo sapiens_hsa042602.24774508
11Asthma_Homo sapiens_hsa053102.23309808
12Autoimmune thyroid disease_Homo sapiens_hsa053202.16846514
13Allograft rejection_Homo sapiens_hsa053302.16670791
14Graft-versus-host disease_Homo sapiens_hsa053321.99683985
15Antigen processing and presentation_Homo sapiens_hsa046121.98017307
16RNA polymerase_Homo sapiens_hsa030201.96627810
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.91478128
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79787127
19Type I diabetes mellitus_Homo sapiens_hsa049401.78228864
20Phototransduction_Homo sapiens_hsa047441.73725640
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71121092
22Hematopoietic cell lineage_Homo sapiens_hsa046401.48970206
23Linoleic acid metabolism_Homo sapiens_hsa005911.47299645
24RNA degradation_Homo sapiens_hsa030181.45511053
25Nitrogen metabolism_Homo sapiens_hsa009101.37980304
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36198255
27Homologous recombination_Homo sapiens_hsa034401.35453493
28Rheumatoid arthritis_Homo sapiens_hsa053231.33257796
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27001541
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18212428
31Basal transcription factors_Homo sapiens_hsa030221.11568109
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08966161
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07492036
34Tryptophan metabolism_Homo sapiens_hsa003801.00698765
35T cell receptor signaling pathway_Homo sapiens_hsa046600.98155765
36Collecting duct acid secretion_Homo sapiens_hsa049660.97907907
37Nicotine addiction_Homo sapiens_hsa050330.96593878
38Caffeine metabolism_Homo sapiens_hsa002320.96043511
39Olfactory transduction_Homo sapiens_hsa047400.93665881
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93036948
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.92457371
42Butanoate metabolism_Homo sapiens_hsa006500.88356539
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87257884
44Chemical carcinogenesis_Homo sapiens_hsa052040.84375468
45One carbon pool by folate_Homo sapiens_hsa006700.82085909
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81706601
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.79175307
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79062829
49Viral myocarditis_Homo sapiens_hsa054160.78047555
50Retinol metabolism_Homo sapiens_hsa008300.77853848
51Pyrimidine metabolism_Homo sapiens_hsa002400.77090588
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.76969572
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73378638
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70942453
55Ether lipid metabolism_Homo sapiens_hsa005650.70713541
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70538028
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69873981
58Taste transduction_Homo sapiens_hsa047420.68453833
59Peroxisome_Homo sapiens_hsa041460.66344465
60Arachidonic acid metabolism_Homo sapiens_hsa005900.65440927
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63764780
62Systemic lupus erythematosus_Homo sapiens_hsa053220.61818213
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60774979
64Propanoate metabolism_Homo sapiens_hsa006400.58620166
65Purine metabolism_Homo sapiens_hsa002300.57718180
66Staphylococcus aureus infection_Homo sapiens_hsa051500.53172022
67Metabolic pathways_Homo sapiens_hsa011000.52984297
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.51082327
69Fanconi anemia pathway_Homo sapiens_hsa034600.50820766
70Malaria_Homo sapiens_hsa051440.49851714
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.49301181
72Mismatch repair_Homo sapiens_hsa034300.48435117
73Spliceosome_Homo sapiens_hsa030400.48423184
74Nucleotide excision repair_Homo sapiens_hsa034200.46914434
75Morphine addiction_Homo sapiens_hsa050320.46382727
76Sulfur metabolism_Homo sapiens_hsa009200.44768712
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43401197
78Salivary secretion_Homo sapiens_hsa049700.42790539
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39229351
80DNA replication_Homo sapiens_hsa030300.38061288
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37859366
82African trypanosomiasis_Homo sapiens_hsa051430.37088151
83Regulation of autophagy_Homo sapiens_hsa041400.35981553
84Fat digestion and absorption_Homo sapiens_hsa049750.35644128
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35007143
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34914106
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34735832
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34082551
89GABAergic synapse_Homo sapiens_hsa047270.31368955
90Base excision repair_Homo sapiens_hsa034100.31093045
91Measles_Homo sapiens_hsa051620.26461572
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25831388
93Fatty acid degradation_Homo sapiens_hsa000710.25556171
94Sulfur relay system_Homo sapiens_hsa041220.23773774
95RNA transport_Homo sapiens_hsa030130.23622658
96Herpes simplex infection_Homo sapiens_hsa051680.22054692
97Ovarian steroidogenesis_Homo sapiens_hsa049130.19050309
98Insulin secretion_Homo sapiens_hsa049110.16672250
99Serotonergic synapse_Homo sapiens_hsa047260.15483274
100Mineral absorption_Homo sapiens_hsa049780.12732782

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