RPS26P47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)9.13956243
2cytidine deamination (GO:0009972)9.13956243
3cytidine metabolic process (GO:0046087)9.13956243
4DNA deamination (GO:0045006)8.20085528
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.15028538
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.07612141
7regulation of activation of Janus kinase activity (GO:0010533)6.15065804
8Arp2/3 complex-mediated actin nucleation (GO:0034314)5.14873354
9actin nucleation (GO:0045010)4.81622961
10positive T cell selection (GO:0043368)4.81368520
11positive thymic T cell selection (GO:0045059)4.77321800
12regulation of B cell receptor signaling pathway (GO:0050855)4.72292063
13negative regulation by host of viral transcription (GO:0043922)4.46049672
14negative regulation of mast cell activation (GO:0033004)4.42617104
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38575279
16positive regulation of interleukin-8 secretion (GO:2000484)4.35908147
17pyrimidine nucleoside catabolic process (GO:0046135)4.31769588
18negative regulation of T cell apoptotic process (GO:0070233)4.28302899
19cytolysis (GO:0019835)4.26827313
20sequestering of actin monomers (GO:0042989)4.17270990
21negative T cell selection (GO:0043383)4.10773098
22negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.10466384
23eosinophil chemotaxis (GO:0048245)4.02581518
24positive regulation of natural killer cell mediated immunity (GO:0002717)4.01931353
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.98293548
26negative regulation of viral genome replication (GO:0045071)3.92353555
27regulation of T cell receptor signaling pathway (GO:0050856)3.88220649
28positive regulation of calcium-mediated signaling (GO:0050850)3.82368687
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82129136
30regulation of regulatory T cell differentiation (GO:0045589)3.80284928
31T cell migration (GO:0072678)3.73909979
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.70667156
33macrophage chemotaxis (GO:0048246)3.69456994
34ribosomal small subunit assembly (GO:0000028)3.66885487
35eosinophil migration (GO:0072677)3.66247080
36positive regulation of tolerance induction (GO:0002645)3.63644426
37negative regulation of B cell proliferation (GO:0030889)3.59823079
38regulation of natural killer cell mediated immunity (GO:0002715)3.59526872
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.59526872
40ATP synthesis coupled proton transport (GO:0015986)3.58477627
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58477627
42positive regulation of gamma-delta T cell activation (GO:0046645)3.57370688
43thymic T cell selection (GO:0045061)3.54677601
44positive regulation of B cell differentiation (GO:0045579)3.52382218
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52325046
46regulation of T cell tolerance induction (GO:0002664)3.51959014
47regulation of interleukin-8 secretion (GO:2000482)3.51160225
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.41548761
49positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.39539116
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34561655
51respiratory electron transport chain (GO:0022904)3.34466497
52regulation of leukocyte mediated cytotoxicity (GO:0001910)3.30882971
53electron transport chain (GO:0022900)3.29834747
54regulation of chronic inflammatory response (GO:0002676)3.29280988
55positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29030142
56positive regulation of cell killing (GO:0031343)3.25674689
57cellular response to interleukin-15 (GO:0071350)3.19907407
58iron-sulfur cluster assembly (GO:0016226)3.17203870
59metallo-sulfur cluster assembly (GO:0031163)3.17203870
60platelet dense granule organization (GO:0060155)3.15416105
61positive regulation of T cell apoptotic process (GO:0070234)3.10260118
62response to interferon-beta (GO:0035456)3.09315091
63positive regulation of uterine smooth muscle contraction (GO:0070474)3.08795512
64negative regulation of lymphocyte apoptotic process (GO:0070229)3.08303153
65negative thymic T cell selection (GO:0045060)3.07717305
66T cell selection (GO:0045058)3.07319164
67positive regulation of defense response to virus by host (GO:0002230)3.06676136
68negative regulation of phagocytosis (GO:0050765)3.05849380
69pyrimidine-containing compound catabolic process (GO:0072529)3.05412124
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01897362
71regulation of gamma-delta T cell differentiation (GO:0045586)3.01298397
72regulation of T cell apoptotic process (GO:0070232)3.00827837
73protein complex biogenesis (GO:0070271)2.97615926
74regulation of T cell mediated cytotoxicity (GO:0001914)2.97388368
75DNA demethylation (GO:0080111)2.96820806
76regulation of B cell differentiation (GO:0045577)2.96021577
77regulation of cell killing (GO:0031341)2.94712727
78regulation of tolerance induction (GO:0002643)2.93571662
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93333417
80T cell costimulation (GO:0031295)2.92623212
81positive regulation of lymphocyte migration (GO:2000403)2.91547510
82lymphocyte costimulation (GO:0031294)2.90021145
83DNA dealkylation (GO:0035510)2.88974383
84T cell receptor signaling pathway (GO:0050852)2.84530410
85regulation of cellular amino acid metabolic process (GO:0006521)2.82936788
86negative regulation of T cell receptor signaling pathway (GO:0050860)2.81819068
87regulation of lymphocyte chemotaxis (GO:1901623)2.78752007
88protein neddylation (GO:0045116)2.76898524
89negative regulation of stress fiber assembly (GO:0051497)2.74069997
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73444066
91regulation of viral genome replication (GO:0045069)2.72994253
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72962559
93monocyte chemotaxis (GO:0002548)2.71280265
94regulation of calcium-mediated signaling (GO:0050848)2.68673706
95viral transcription (GO:0019083)2.68670766
96positive regulation of monocyte chemotaxis (GO:0090026)2.67513452
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67138425
98ribosomal small subunit biogenesis (GO:0042274)2.63398780
99positive regulation of interleukin-4 production (GO:0032753)2.62686526
100negative regulation of viral transcription (GO:0032897)2.59537393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.65533649
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63927684
3EZH2_22144423_ChIP-Seq_EOC_Human3.48354110
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44872318
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41654819
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37391710
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29698552
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.27828504
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.02995904
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69727623
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.24656575
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16310263
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.15108794
14MYB_26560356_Chip-Seq_TH2_Human2.07633662
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01361207
16IGF1R_20145208_ChIP-Seq_DFB_Human2.00701860
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99523996
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.97664231
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92464937
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84022312
21VDR_22108803_ChIP-Seq_LS180_Human1.82586220
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82274237
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71132774
24GATA3_27048872_Chip-Seq_THYMUS_Human1.62784828
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.62034087
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61628752
27GATA3_26560356_Chip-Seq_TH2_Human1.60738683
28VDR_23849224_ChIP-Seq_CD4+_Human1.58839120
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57591328
30RUNX_20019798_ChIP-Seq_JUKART_Human1.52563834
31HTT_18923047_ChIP-ChIP_STHdh_Human1.50088648
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49292832
33ZNF274_21170338_ChIP-Seq_K562_Hela1.47764102
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47574899
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47059763
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44563259
37TAF2_19829295_ChIP-Seq_ESCs_Human1.38642223
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.37614264
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36049667
40BCL6_27268052_Chip-Seq_Bcells_Human1.34881481
41FOXP3_21729870_ChIP-Seq_TREG_Human1.33588218
42NANOG_20526341_ChIP-Seq_ESCs_Human1.31761623
43MYB_26560356_Chip-Seq_TH1_Human1.31247054
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30430507
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30218478
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.29661348
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29639552
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29451974
49AR_20517297_ChIP-Seq_VCAP_Human1.29373023
50NCOR_22424771_ChIP-Seq_293T_Human1.29073488
51TP53_22573176_ChIP-Seq_HFKS_Human1.28837012
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28755744
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26859832
54CTCF_20526341_ChIP-Seq_ESCs_Human1.26286060
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25772189
56UTX_26944678_Chip-Seq_JUKART_Human1.25068343
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17578410
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.12812732
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12812732
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.12616379
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10942461
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10056740
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.09203982
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08299017
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07534279
66MYC_18940864_ChIP-ChIP_HL60_Human1.07421823
67P300_27268052_Chip-Seq_Bcells_Human1.03761340
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.03396273
69ERG_20517297_ChIP-Seq_VCAP_Human1.03321832
70MAF_26560356_Chip-Seq_TH2_Human1.03147764
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03051652
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.01405743
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00468401
74NANOG_19829295_ChIP-Seq_ESCs_Human0.96998327
75SOX2_19829295_ChIP-Seq_ESCs_Human0.96998327
76MYC_19829295_ChIP-Seq_ESCs_Human0.96752678
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96666365
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96358202
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.96146456
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.95738902
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95419157
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95097807
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92860803
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92726042
85E2F1_20622854_ChIP-Seq_HELA_Human0.92152163
86P53_21459846_ChIP-Seq_SAOS-2_Human0.91973437
87ERA_21632823_ChIP-Seq_H3396_Human0.91554944
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91159552
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91075544
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90945321
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.90429807
92BCOR_27268052_Chip-Seq_Bcells_Human0.89303601
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87996031
94ER_23166858_ChIP-Seq_MCF-7_Human0.87266249
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87251274
96STAT1_20625510_ChIP-Seq_HELA_Human0.86908881
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86144887
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84357872
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84095644
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83867807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.85616185
2MP0009785_altered_susceptibility_to3.23797934
3MP0003763_abnormal_thymus_physiology2.95827692
4MP0001835_abnormal_antigen_presentation2.69588839
5MP0009333_abnormal_splenocyte_physiolog2.61751195
6MP0009379_abnormal_foot_pigmentation2.55871714
7MP0003646_muscle_fatigue2.42462731
8MP0005000_abnormal_immune_tolerance2.21480899
9MP0005025_abnormal_response_to2.19508296
10MP0001800_abnormal_humoral_immune2.06144258
11MP0002420_abnormal_adaptive_immunity2.03680168
12MP0001873_stomach_inflammation2.03077555
13MP0006082_CNS_inflammation2.02544919
14MP0002166_altered_tumor_susceptibility1.98425778
15MP0001819_abnormal_immune_cell1.94856054
16MP0005646_abnormal_pituitary_gland1.94780005
17MP0002148_abnormal_hypersensitivity_rea1.93512819
18MP0005645_abnormal_hypothalamus_physiol1.92481711
19MP0002723_abnormal_immune_serum1.91654505
20MP0003866_abnormal_defecation1.83050019
21MP0000372_irregular_coat_pigmentation1.78503751
22MP0001919_abnormal_reproductive_system1.72909313
23MP0001790_abnormal_immune_system1.69390705
24MP0005387_immune_system_phenotype1.69390705
25MP0005389_reproductive_system_phenotype1.67653212
26MP0002277_abnormal_respiratory_mucosa1.66654311
27MP0002163_abnormal_gland_morphology1.66465411
28MP0000685_abnormal_immune_system1.64626815
29MP0000716_abnormal_immune_system1.57159479
30MP0002452_abnormal_antigen_presenting1.54554026
31MP0002398_abnormal_bone_marrow1.53438489
32MP0002006_tumorigenesis1.50743108
33MP0002102_abnormal_ear_morphology1.43721569
34MP0000703_abnormal_thymus_morphology1.42964803
35MP0010155_abnormal_intestine_physiology1.42382121
36MP0005551_abnormal_eye_electrophysiolog1.39569005
37MP0004145_abnormal_muscle_electrophysio1.38004092
38MP0002160_abnormal_reproductive_system1.34844650
39MP0002405_respiratory_system_inflammati1.33517927
40MP0002933_joint_inflammation1.33371397
41MP0001905_abnormal_dopamine_level1.29884913
42MP0002234_abnormal_pharynx_morphology1.29685845
43MP0002095_abnormal_skin_pigmentation1.29630100
44MP0001485_abnormal_pinna_reflex1.29397883
45MP0008872_abnormal_physiological_respon1.28382142
46MP0005377_hearing/vestibular/ear_phenot1.28151340
47MP0003878_abnormal_ear_physiology1.28151340
48MP0002722_abnormal_immune_system1.27469725
49MP0006072_abnormal_retinal_apoptosis1.27155467
50MP0005075_abnormal_melanosome_morpholog1.26143600
51MP0005410_abnormal_fertilization1.25894643
52MP0000689_abnormal_spleen_morphology1.25603942
53MP0006292_abnormal_olfactory_placode1.24825858
54MP0008875_abnormal_xenobiotic_pharmacok1.23626201
55MP0002638_abnormal_pupillary_reflex1.22880698
56MP0003786_premature_aging1.22057998
57MP0002429_abnormal_blood_cell1.19181039
58MP0002876_abnormal_thyroid_physiology1.19140416
59MP0001845_abnormal_inflammatory_respons1.18939817
60MP0008877_abnormal_DNA_methylation1.08551266
61MP0002419_abnormal_innate_immunity1.08432286
62MP0001853_heart_inflammation1.07882025
63MP0001968_abnormal_touch/_nociception1.05507268
64MP0002736_abnormal_nociception_after1.03897524
65MP0006036_abnormal_mitochondrial_physio1.03142667
66MP0003195_calcinosis1.02848571
67MP0002138_abnormal_hepatobiliary_system1.02525850
68MP0003011_delayed_dark_adaptation1.02303940
69MP0002693_abnormal_pancreas_physiology1.01367509
70MP0003806_abnormal_nucleotide_metabolis1.00568873
71MP0010386_abnormal_urinary_bladder0.99079459
72MP0008469_abnormal_protein_level0.98427578
73MP0005174_abnormal_tail_pigmentation0.97560169
74MP0004142_abnormal_muscle_tone0.96261607
75MP0008995_early_reproductive_senescence0.93972905
76MP0005253_abnormal_eye_physiology0.93657038
77MP0005636_abnormal_mineral_homeostasis0.92193305
78MP0004147_increased_porphyrin_level0.90928319
79MP0006276_abnormal_autonomic_nervous0.90333999
80MP0009745_abnormal_behavioral_response0.89564513
81MP0005464_abnormal_platelet_physiology0.89103387
82MP0003448_altered_tumor_morphology0.88844949
83MP0001764_abnormal_homeostasis0.86824669
84MP0001765_abnormal_ion_homeostasis0.85250858
85MP0001119_abnormal_female_reproductive0.84652474
86MP0001986_abnormal_taste_sensitivity0.84627088
87MP0000678_abnormal_parathyroid_gland0.84057777
88MP0005379_endocrine/exocrine_gland_phen0.83690096
89MP0009763_increased_sensitivity_to0.83672523
90MP0008789_abnormal_olfactory_epithelium0.81742117
91MP0003137_abnormal_impulse_conducting0.80377004
92MP0002822_catalepsy0.80044791
93MP0003045_fibrosis0.79766032
94MP0004043_abnormal_pH_regulation0.79460969
95MP0003880_abnormal_central_pattern0.77365220
96MP0002019_abnormal_tumor_incidence0.75650916
97MP0004885_abnormal_endolymph0.72810240
98MP0002733_abnormal_thermal_nociception0.71406235
99MP0002837_dystrophic_cardiac_calcinosis0.69708915
100MP0002132_abnormal_respiratory_system0.69705842

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.15566225
2T lymphocytopenia (HP:0005403)4.86686675
3Abnormality of T cell number (HP:0011839)4.74494731
4Hypoproteinemia (HP:0003075)4.61631616
5Severe combined immunodeficiency (HP:0004430)4.37275635
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.22936542
7IgG deficiency (HP:0004315)3.96293463
8Autoimmune hemolytic anemia (HP:0001890)3.86340547
9Abnormality of B cell number (HP:0010975)3.81160630
10Congenital stationary night blindness (HP:0007642)3.80267887
113-Methylglutaconic aciduria (HP:0003535)3.70553067
12Mitochondrial inheritance (HP:0001427)3.66181470
13Increased intramyocellular lipid droplets (HP:0012240)3.61530560
14Elevated erythrocyte sedimentation rate (HP:0003565)3.49895253
15Combined immunodeficiency (HP:0005387)3.49060223
16Acute necrotizing encephalopathy (HP:0006965)3.48633835
17Thyroiditis (HP:0100646)3.46289570
18Renal Fanconi syndrome (HP:0001994)3.45011999
19Abnormality of T cells (HP:0002843)3.36668044
20Abnormal mitochondria in muscle tissue (HP:0008316)3.31775976
21Increased hepatocellular lipid droplets (HP:0006565)3.29430024
22B lymphocytopenia (HP:0010976)3.28511977
23Severe visual impairment (HP:0001141)3.20391376
24Increased IgM level (HP:0003496)3.16138945
25Abnormal rod and cone electroretinograms (HP:0008323)3.04808439
26Increased CSF lactate (HP:0002490)3.02186029
27Abnormality of eosinophils (HP:0001879)3.01373380
28Increased muscle lipid content (HP:0009058)2.95525367
29Lipid accumulation in hepatocytes (HP:0006561)2.85522121
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85140273
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85140273
32Progressive macrocephaly (HP:0004481)2.82807191
33Cerebral edema (HP:0002181)2.76860072
34Acute encephalopathy (HP:0006846)2.75871440
35Eosinophilia (HP:0001880)2.74191309
36Abnormality of the prostate (HP:0008775)2.71499172
37Pancreatic cysts (HP:0001737)2.58455876
38Hepatocellular necrosis (HP:0001404)2.57902700
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56178120
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56132885
41Hypoplasia of the thymus (HP:0000778)2.52963707
42Encephalitis (HP:0002383)2.51050179
43Decreased central vision (HP:0007663)2.50312253
44Attenuation of retinal blood vessels (HP:0007843)2.46896015
45Hepatic necrosis (HP:0002605)2.44397031
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.42380613
47Microretrognathia (HP:0000308)2.37932912
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34925923
49Pancytopenia (HP:0001876)2.34711450
50Exertional dyspnea (HP:0002875)2.33044221
51Hypoalbuminemia (HP:0003073)2.32028030
52Abnormal albumin level (HP:0012116)2.32028030
53Abnormality of midbrain morphology (HP:0002418)2.28323778
54Molar tooth sign on MRI (HP:0002419)2.28323778
55Stomatitis (HP:0010280)2.28011154
56Chronic diarrhea (HP:0002028)2.26574611
57Leukocytosis (HP:0001974)2.25420980
58Meningitis (HP:0001287)2.24046258
59Panhypogammaglobulinemia (HP:0003139)2.18488771
60Optic disc pallor (HP:0000543)2.18290096
61Generalized aminoaciduria (HP:0002909)2.15085990
62Granulocytopenia (HP:0001913)2.12908901
63Pendular nystagmus (HP:0012043)2.10649622
64Lymphopenia (HP:0001888)2.09727315
65Methylmalonic acidemia (HP:0002912)2.08274393
66Obstructive lung disease (HP:0006536)2.07390536
67Chronic obstructive pulmonary disease (HP:0006510)2.07390536
68Recurrent bronchitis (HP:0002837)2.07256907
69Abnormality of macrophages (HP:0004311)2.06236454
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.02664307
71True hermaphroditism (HP:0010459)2.02007758
72Abnormality of renal resorption (HP:0011038)2.01989352
73Abnormal number of erythroid precursors (HP:0012131)1.99401284
74Autoimmune thrombocytopenia (HP:0001973)1.99257683
75Polydipsia (HP:0001959)1.97140475
76Abnormal drinking behavior (HP:0030082)1.97140475
77Ketosis (HP:0001946)1.96321191
78Lactic acidosis (HP:0003128)1.95657592
79Reticulocytopenia (HP:0001896)1.94845429
80Ureteral stenosis (HP:0000071)1.94605665
81Increased serum lactate (HP:0002151)1.94074358
82Agammaglobulinemia (HP:0004432)1.92226048
83Pancreatic fibrosis (HP:0100732)1.91884552
84Renal cortical cysts (HP:0000803)1.91435916
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89643121
86Gastrointestinal infarctions (HP:0005244)1.89393516
87Methylmalonic aciduria (HP:0012120)1.87847197
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87377669
89Dicarboxylic aciduria (HP:0003215)1.87377669
90Abnormality of urine glucose concentration (HP:0011016)1.85010605
91Glycosuria (HP:0003076)1.85010605
92Abnormality of T cell physiology (HP:0011840)1.84983100
93Constricted visual fields (HP:0001133)1.84140373
94Abnormality of the renal cortex (HP:0011035)1.82680589
95Exercise intolerance (HP:0003546)1.82281502
96Abnormality of cells of the erythroid lineage (HP:0012130)1.81074707
97Gangrene (HP:0100758)1.80192550
98Lethargy (HP:0001254)1.79213798
99Ureteral obstruction (HP:0006000)1.78995226
100Bronchitis (HP:0012387)1.78897888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.81698250
2TXK5.54945878
3TESK25.53072882
4BCKDK5.04845788
5LIMK13.14008155
6MAP4K12.68350619
7ADRBK22.49092250
8ITK2.30032062
9GRK12.27468797
10ZAK2.04341178
11VRK21.78459623
12MAP4K21.76417713
13MAP3K111.75183716
14TAOK31.71625429
15BUB11.69880456
16TESK11.68070508
17TLK11.42881914
18VRK11.42388150
19FES1.32603967
20MUSK1.30881997
21TNK21.22849681
22PASK1.21351185
23SYK1.20874580
24CAMKK21.18290192
25PRKCQ1.17683399
26EIF2AK31.15866423
27TEC1.10957847
28CSK1.07926525
29TIE11.05173168
30STK161.03073600
31GRK61.01792474
32LCK0.99883535
33ZAP700.99185748
34SCYL20.96771284
35CDK80.96025837
36MST40.95542521
37GRK70.89696321
38BTK0.87491409
39CAMKK10.86628603
40PINK10.86505521
41MAP3K120.86091721
42AURKA0.85987899
43WNK40.85416448
44NUAK10.83381905
45MAPKAPK30.82092410
46FRK0.79807964
47INSRR0.77923100
48IKBKE0.77746222
49LYN0.77057060
50PIM20.68907077
51IKBKB0.64309500
52OBSCN0.60982051
53MAP2K60.60720135
54PIM10.60270617
55ROCK10.59375849
56MAPK150.58585749
57RPS6KA50.58105411
58PIK3CA0.55726763
59JAK30.54649874
60BMPR1B0.53208700
61KIT0.51907746
62SRPK10.50582119
63PIK3CG0.50500897
64MYLK0.49393373
65CLK10.47389476
66ADRBK10.46718884
67BRSK10.46538003
68WNK30.46477534
69MAPK130.42444566
70CDK190.41974051
71IGF1R0.40973219
72ABL20.40068733
73PRKCA0.39155039
74DAPK10.37883829
75PRKACA0.37862311
76FYN0.37683445
77CSF1R0.37574711
78TYRO30.36025278
79MAP2K70.35673076
80TBK10.34083339
81PLK40.34045384
82MATK0.33901232
83INSR0.33589917
84PAK10.32260416
85NTRK20.30683086
86BLK0.30406561
87NME10.30293478
88IRAK40.28251067
89MAPK110.27808640
90RPS6KA40.27216898
91CSNK2A10.26887522
92CAMK2A0.26245716
93CSNK2A20.25257624
94ABL10.24052547
95CDC42BPA0.23853782
96RIPK40.23431912
97MAPKAPK20.23297748
98ATR0.22892326
99CAMK10.21657009
100PRKCH0.20633058

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.49554334
2Proteasome_Homo sapiens_hsa030503.89815157
3Oxidative phosphorylation_Homo sapiens_hsa001903.49672569
4Ribosome_Homo sapiens_hsa030103.13260505
5Graft-versus-host disease_Homo sapiens_hsa053322.99695201
6Parkinsons disease_Homo sapiens_hsa050122.95920283
7Antigen processing and presentation_Homo sapiens_hsa046122.87820589
8Autoimmune thyroid disease_Homo sapiens_hsa053202.82067356
9Allograft rejection_Homo sapiens_hsa053302.54849894
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42426192
11Hematopoietic cell lineage_Homo sapiens_hsa046402.37768089
12Type I diabetes mellitus_Homo sapiens_hsa049402.13781461
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09502557
14RNA polymerase_Homo sapiens_hsa030202.08996306
15Alzheimers disease_Homo sapiens_hsa050101.91918738
16T cell receptor signaling pathway_Homo sapiens_hsa046601.90667278
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84035700
18Phototransduction_Homo sapiens_hsa047441.83086064
19Huntingtons disease_Homo sapiens_hsa050161.75429412
20Cardiac muscle contraction_Homo sapiens_hsa042601.60996729
21Rheumatoid arthritis_Homo sapiens_hsa053231.55755648
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51824391
23Linoleic acid metabolism_Homo sapiens_hsa005911.37812506
24Protein export_Homo sapiens_hsa030601.35370549
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21221558
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19002456
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.15524997
28Caffeine metabolism_Homo sapiens_hsa002321.15324870
29Nitrogen metabolism_Homo sapiens_hsa009101.13728903
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12598380
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11762594
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11582835
33Homologous recombination_Homo sapiens_hsa034401.07152643
34Sulfur relay system_Homo sapiens_hsa041221.04815811
35Measles_Homo sapiens_hsa051621.02466469
36Asthma_Homo sapiens_hsa053101.02412842
37RNA degradation_Homo sapiens_hsa030180.98452823
38Viral myocarditis_Homo sapiens_hsa054160.97363179
39Pyrimidine metabolism_Homo sapiens_hsa002400.95195045
40Olfactory transduction_Homo sapiens_hsa047400.93672655
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.86578531
42Propanoate metabolism_Homo sapiens_hsa006400.86454815
43Malaria_Homo sapiens_hsa051440.85276734
44Retinol metabolism_Homo sapiens_hsa008300.83273914
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81878876
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76698172
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.76328064
48Salmonella infection_Homo sapiens_hsa051320.74978307
49Peroxisome_Homo sapiens_hsa041460.71029995
50Purine metabolism_Homo sapiens_hsa002300.70412270
51Systemic lupus erythematosus_Homo sapiens_hsa053220.69404060
52Fanconi anemia pathway_Homo sapiens_hsa034600.68588353
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68541007
54Arachidonic acid metabolism_Homo sapiens_hsa005900.67638575
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67088926
56Butanoate metabolism_Homo sapiens_hsa006500.66899033
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62287524
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60786309
59Chemical carcinogenesis_Homo sapiens_hsa052040.57474123
60One carbon pool by folate_Homo sapiens_hsa006700.56385805
61Collecting duct acid secretion_Homo sapiens_hsa049660.56327557
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55774279
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54858772
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.53672341
65Shigellosis_Homo sapiens_hsa051310.53111183
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52783609
67Nucleotide excision repair_Homo sapiens_hsa034200.51562086
68Ether lipid metabolism_Homo sapiens_hsa005650.51135547
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.50326428
70Taste transduction_Homo sapiens_hsa047420.47996854
71Nicotine addiction_Homo sapiens_hsa050330.47159283
72DNA replication_Homo sapiens_hsa030300.46722736
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46707801
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46136715
75Basal transcription factors_Homo sapiens_hsa030220.45922128
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45704889
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41477694
78Metabolic pathways_Homo sapiens_hsa011000.39681756
79Mismatch repair_Homo sapiens_hsa034300.38990225
80Sulfur metabolism_Homo sapiens_hsa009200.37321994
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36880901
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36042237
83Staphylococcus aureus infection_Homo sapiens_hsa051500.34663306
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33397787
85Ovarian steroidogenesis_Homo sapiens_hsa049130.33252381
86Spliceosome_Homo sapiens_hsa030400.32225599
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31502601
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.31187526
89Legionellosis_Homo sapiens_hsa051340.30696680
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29334259
91Herpes simplex infection_Homo sapiens_hsa051680.27574723
92Chemokine signaling pathway_Homo sapiens_hsa040620.27054274
93ABC transporters_Homo sapiens_hsa020100.26619005
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26438035
95Regulation of autophagy_Homo sapiens_hsa041400.25742438
96Morphine addiction_Homo sapiens_hsa050320.25185753
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24002611
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23464262
99Calcium signaling pathway_Homo sapiens_hsa040200.19954027
100Selenocompound metabolism_Homo sapiens_hsa004500.19134503

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