RPS18P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.75205303
2viral transcription (GO:0019083)6.28875508
3translational termination (GO:0006415)6.02328976
4ATP synthesis coupled proton transport (GO:0015986)5.94628993
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.94628993
6DNA deamination (GO:0045006)5.76687589
7ribosomal small subunit biogenesis (GO:0042274)5.67252529
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60606033
9translational elongation (GO:0006414)5.29848098
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29242793
11cotranslational protein targeting to membrane (GO:0006613)5.21392919
12protein targeting to ER (GO:0045047)5.18956208
13maturation of SSU-rRNA (GO:0030490)5.17672256
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.97517011
15protein localization to endoplasmic reticulum (GO:0070972)4.89501520
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.77627577
17viral life cycle (GO:0019058)4.61103102
18cellular protein complex disassembly (GO:0043624)4.49584357
19behavioral response to nicotine (GO:0035095)4.47345249
20respiratory electron transport chain (GO:0022904)4.34309229
21electron transport chain (GO:0022900)4.32802518
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24364223
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.21572496
24chaperone-mediated protein transport (GO:0072321)4.17339937
25protein complex biogenesis (GO:0070271)4.16181135
26protein neddylation (GO:0045116)4.06596627
27translational initiation (GO:0006413)4.04957420
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97162843
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.97162843
30NADH dehydrogenase complex assembly (GO:0010257)3.97162843
31cytidine metabolic process (GO:0046087)3.96805850
32cytidine catabolic process (GO:0006216)3.96805850
33cytidine deamination (GO:0009972)3.96805850
34ribosomal large subunit biogenesis (GO:0042273)3.95960130
35translation (GO:0006412)3.79205595
36mitochondrial respiratory chain complex assembly (GO:0033108)3.76066251
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.75931567
38protein complex disassembly (GO:0043241)3.68385114
39ATP biosynthetic process (GO:0006754)3.54777847
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.53081204
41macromolecular complex disassembly (GO:0032984)3.52242997
42water-soluble vitamin biosynthetic process (GO:0042364)3.51917066
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.48995484
44GTP biosynthetic process (GO:0006183)3.47708503
45pyrimidine ribonucleoside catabolic process (GO:0046133)3.47316514
46protein targeting to membrane (GO:0006612)3.44456315
47cellular component biogenesis (GO:0044085)3.41686762
48respiratory chain complex IV assembly (GO:0008535)3.40025469
49ribonucleoprotein complex biogenesis (GO:0022613)3.32001089
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29586910
51hydrogen ion transmembrane transport (GO:1902600)3.26762367
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19675331
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17248513
54nuclear-transcribed mRNA catabolic process (GO:0000956)3.17046289
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12667230
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12667230
57protein-cofactor linkage (GO:0018065)3.08208380
58cytochrome complex assembly (GO:0017004)3.07933787
59proton transport (GO:0015992)3.06753572
60termination of RNA polymerase III transcription (GO:0006386)3.06021153
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.06021153
62preassembly of GPI anchor in ER membrane (GO:0016254)3.02081272
63hydrogen transport (GO:0006818)3.01798408
64mRNA catabolic process (GO:0006402)2.98686928
65ribonucleoside triphosphate biosynthetic process (GO:0009201)2.97911718
66UTP biosynthetic process (GO:0006228)2.82739892
67kynurenine metabolic process (GO:0070189)2.80668133
68GPI anchor metabolic process (GO:0006505)2.78201951
69ubiquinone biosynthetic process (GO:0006744)2.75296338
70sequestering of actin monomers (GO:0042989)2.73315621
71platelet dense granule organization (GO:0060155)2.72779125
72pyrimidine nucleotide catabolic process (GO:0006244)2.71100066
73mannosylation (GO:0097502)2.70033035
74GPI anchor biosynthetic process (GO:0006506)2.69460018
75RNA catabolic process (GO:0006401)2.69184286
76pseudouridine synthesis (GO:0001522)2.68227155
77rRNA processing (GO:0006364)2.66225097
78metallo-sulfur cluster assembly (GO:0031163)2.64562836
79iron-sulfur cluster assembly (GO:0016226)2.64562836
80indole-containing compound catabolic process (GO:0042436)2.63677387
81indolalkylamine catabolic process (GO:0046218)2.63677387
82tryptophan catabolic process (GO:0006569)2.63677387
83rRNA metabolic process (GO:0016072)2.63304856
84base-excision repair, AP site formation (GO:0006285)2.63296303
85UTP metabolic process (GO:0046051)2.62002427
86positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.57782573
87nucleoside triphosphate biosynthetic process (GO:0009142)2.57240779
88indolalkylamine metabolic process (GO:0006586)2.51583989
89regulation of cellular amino acid metabolic process (GO:0006521)2.49509543
90positive regulation of T cell apoptotic process (GO:0070234)2.46797264
91protein polyglutamylation (GO:0018095)2.45354344
92rRNA modification (GO:0000154)2.44947744
93protein targeting to mitochondrion (GO:0006626)2.43212032
94positive regulation of respiratory burst (GO:0060267)2.41769554
95regulation of isotype switching to IgG isotypes (GO:0048302)2.41490746
96piRNA metabolic process (GO:0034587)2.40940474
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.40232227
98establishment of protein localization to mitochondrion (GO:0072655)2.39508909
99tRNA processing (GO:0008033)2.38672349
100ubiquinone metabolic process (GO:0006743)2.38533240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.61753236
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94077760
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51333437
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28088174
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.26560289
6EZH2_22144423_ChIP-Seq_EOC_Human3.10902169
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.95265255
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90182552
9VDR_22108803_ChIP-Seq_LS180_Human2.85910062
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75283947
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.58202591
12ZNF274_21170338_ChIP-Seq_K562_Hela2.49460135
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47862632
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31869271
15VDR_23849224_ChIP-Seq_CD4+_Human2.20909511
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93313462
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90180179
18FOXP3_21729870_ChIP-Seq_TREG_Human1.79858547
19MYC_18940864_ChIP-ChIP_HL60_Human1.76050889
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.70086823
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.68322786
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66591370
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66085304
24ELK1_19687146_ChIP-ChIP_HELA_Human1.65424229
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63671052
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62039652
27TP53_22573176_ChIP-Seq_HFKS_Human1.59015647
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.54655704
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49410042
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.47970796
31IGF1R_20145208_ChIP-Seq_DFB_Human1.47945737
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45418334
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43201412
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39736756
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38632053
36IRF1_19129219_ChIP-ChIP_H3396_Human1.38130128
37TAF2_19829295_ChIP-Seq_ESCs_Human1.35196268
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.34797603
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33159742
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.33128744
41EWS_26573619_Chip-Seq_HEK293_Human1.31973070
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31232986
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.30122132
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29981119
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29503606
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28146798
47TTF2_22483619_ChIP-Seq_HELA_Human1.27029166
48AR_20517297_ChIP-Seq_VCAP_Human1.26882925
49NANOG_20526341_ChIP-Seq_ESCs_Human1.26514222
50NCOR_22424771_ChIP-Seq_293T_Human1.24910083
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23761312
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.22054465
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22054465
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20839705
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19217304
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17573226
57ERA_21632823_ChIP-Seq_H3396_Human1.16318604
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15452397
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14442148
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13089993
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12293011
62BCL6_27268052_Chip-Seq_Bcells_Human1.10544064
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.10484178
64GABP_19822575_ChIP-Seq_HepG2_Human1.10397585
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10281549
66GATA3_26560356_Chip-Seq_TH2_Human1.08894216
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08853136
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08789222
69XRN2_22483619_ChIP-Seq_HELA_Human1.08168674
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07979690
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07596768
72MYC_19829295_ChIP-Seq_ESCs_Human1.06674296
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04174230
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.02099759
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01988982
76FUS_26573619_Chip-Seq_HEK293_Human1.01503199
77SOX2_19829295_ChIP-Seq_ESCs_Human0.99347749
78NANOG_19829295_ChIP-Seq_ESCs_Human0.99347749
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98858753
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96635706
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95968918
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.95562080
83P53_21459846_ChIP-Seq_SAOS-2_Human0.95031458
84CTCF_20526341_ChIP-Seq_ESCs_Human0.94786669
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92481411
86ER_23166858_ChIP-Seq_MCF-7_Human0.92435463
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.92415704
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92152247
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91007585
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90930461
91CBP_20019798_ChIP-Seq_JUKART_Human0.90858756
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90858756
93FOXH1_21741376_ChIP-Seq_ESCs_Human0.89791874
94P300_27268052_Chip-Seq_Bcells_Human0.89702629
95REST_21632747_ChIP-Seq_MESCs_Mouse0.89392237
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89360053
97IRF8_21731497_ChIP-ChIP_J774_Mouse0.89331891
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88349864
99ERG_20517297_ChIP-Seq_VCAP_Human0.88045887
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88041903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.98786902
2MP0006292_abnormal_olfactory_placode3.35614513
3MP0005671_abnormal_response_to2.96584896
4MP0008877_abnormal_DNA_methylation2.42197793
5MP0002163_abnormal_gland_morphology2.34563190
6MP0003787_abnormal_imprinting2.17637638
7MP0002102_abnormal_ear_morphology2.15931343
8MP0002837_dystrophic_cardiac_calcinosis2.07477781
9MP0002653_abnormal_ependyma_morphology2.04474524
10MP0001835_abnormal_antigen_presentation2.02231896
11MP0004142_abnormal_muscle_tone1.98855303
12MP0008872_abnormal_physiological_respon1.98212262
13MP0004145_abnormal_muscle_electrophysio1.96319743
14MP0005646_abnormal_pituitary_gland1.95636773
15MP0003646_muscle_fatigue1.90302031
16MP0001986_abnormal_taste_sensitivity1.89555592
17MP0005645_abnormal_hypothalamus_physiol1.83306565
18MP0006276_abnormal_autonomic_nervous1.76573847
19MP0008875_abnormal_xenobiotic_pharmacok1.75782438
20MP0001968_abnormal_touch/_nociception1.75321367
21MP0004147_increased_porphyrin_level1.75196152
22MP0000372_irregular_coat_pigmentation1.73937686
23MP0002736_abnormal_nociception_after1.69360663
24MP0005551_abnormal_eye_electrophysiolog1.65339055
25MP0006072_abnormal_retinal_apoptosis1.58462909
26MP0002876_abnormal_thyroid_physiology1.55800959
27MP0002638_abnormal_pupillary_reflex1.54085579
28MP0008789_abnormal_olfactory_epithelium1.47454587
29MP0005377_hearing/vestibular/ear_phenot1.46645788
30MP0003878_abnormal_ear_physiology1.46645788
31MP0004885_abnormal_endolymph1.45696133
32MP0001905_abnormal_dopamine_level1.45143815
33MP0005379_endocrine/exocrine_gland_phen1.43853968
34MP0003880_abnormal_central_pattern1.37806699
35MP0001873_stomach_inflammation1.36502345
36MP0005389_reproductive_system_phenotype1.36192162
37MP0001800_abnormal_humoral_immune1.35709259
38MP0002277_abnormal_respiratory_mucosa1.34205842
39MP0002234_abnormal_pharynx_morphology1.33725537
40MP0001919_abnormal_reproductive_system1.32597057
41MP0009333_abnormal_splenocyte_physiolog1.32592654
42MP0001529_abnormal_vocalization1.31573353
43MP0002272_abnormal_nervous_system1.31560386
44MP0003011_delayed_dark_adaptation1.30877837
45MP0002148_abnormal_hypersensitivity_rea1.29263823
46MP0009785_altered_susceptibility_to1.27789968
47MP0005423_abnormal_somatic_nervous1.23959559
48MP0002160_abnormal_reproductive_system1.23345671
49MP0005084_abnormal_gallbladder_morpholo1.22307285
50MP0008995_early_reproductive_senescence1.20617612
51MP0002095_abnormal_skin_pigmentation1.19479100
52MP0000685_abnormal_immune_system1.16362435
53MP0003186_abnormal_redox_activity1.16086798
54MP0002138_abnormal_hepatobiliary_system1.14372682
55MP0003786_premature_aging1.13415318
56MP0009745_abnormal_behavioral_response1.12212920
57MP0004742_abnormal_vestibular_system1.11949726
58MP0003806_abnormal_nucleotide_metabolis1.10861144
59MP0001485_abnormal_pinna_reflex1.09714327
60MP0009764_decreased_sensitivity_to1.08895276
61MP0006036_abnormal_mitochondrial_physio1.08061583
62MP0002723_abnormal_immune_serum1.05071902
63MP0001970_abnormal_pain_threshold1.03197190
64MP0005075_abnormal_melanosome_morpholog1.03162421
65MP0002733_abnormal_thermal_nociception1.01147281
66MP0005000_abnormal_immune_tolerance0.98335865
67MP0009046_muscle_twitch0.98226670
68MP0001440_abnormal_grooming_behavior0.96357751
69MP0001293_anophthalmia0.95904402
70MP0001790_abnormal_immune_system0.94624676
71MP0005387_immune_system_phenotype0.94624676
72MP0008058_abnormal_DNA_repair0.94292547
73MP0003866_abnormal_defecation0.93713887
74MP0005253_abnormal_eye_physiology0.91751282
75MP0005499_abnormal_olfactory_system0.91445034
76MP0005394_taste/olfaction_phenotype0.91445034
77MP0002420_abnormal_adaptive_immunity0.87860264
78MP0000631_abnormal_neuroendocrine_gland0.87832626
79MP0001764_abnormal_homeostasis0.85967989
80MP0001819_abnormal_immune_cell0.85737097
81MP0002938_white_spotting0.84164409
82MP0008775_abnormal_heart_ventricle0.82794538
83MP0005195_abnormal_posterior_eye0.82748553
84MP0002452_abnormal_antigen_presenting0.82429702
85MP0002822_catalepsy0.81318508
86MP0000049_abnormal_middle_ear0.80525300
87MP0003121_genomic_imprinting0.78662688
88MP0001663_abnormal_digestive_system0.77867290
89MP0001984_abnormal_olfaction0.75962874
90MP0005174_abnormal_tail_pigmentation0.75501238
91MP0005636_abnormal_mineral_homeostasis0.75476577
92MP0005410_abnormal_fertilization0.75179006
93MP0002735_abnormal_chemical_nociception0.74736186
94MP0002557_abnormal_social/conspecific_i0.74606853
95MP0000230_abnormal_systemic_arterial0.74298148
96MP0006035_abnormal_mitochondrial_morpho0.74091692
97MP0001486_abnormal_startle_reflex0.73817110
98MP0002572_abnormal_emotion/affect_behav0.72450726
99MP0005025_abnormal_response_to0.72088642
100MP0002184_abnormal_innervation0.71832098

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.08325722
2Mitochondrial inheritance (HP:0001427)4.60499015
3Abnormal mitochondria in muscle tissue (HP:0008316)4.58421939
4Acute encephalopathy (HP:0006846)4.30811777
5Progressive macrocephaly (HP:0004481)4.20751937
6Increased CSF lactate (HP:0002490)4.10244563
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.95418618
8Reticulocytopenia (HP:0001896)3.89553610
9Abnormality of cells of the erythroid lineage (HP:0012130)3.79712570
10Hepatocellular necrosis (HP:0001404)3.77135457
11Increased hepatocellular lipid droplets (HP:0006565)3.66387312
12Pancreatic cysts (HP:0001737)3.49640831
13Lipid accumulation in hepatocytes (HP:0006561)3.42664921
14Hepatic necrosis (HP:0002605)3.33214397
15Abnormal number of erythroid precursors (HP:0012131)3.32721582
16Renal Fanconi syndrome (HP:0001994)3.32400713
17Congenital stationary night blindness (HP:0007642)3.29381572
18Cerebral edema (HP:0002181)3.27060907
19Pancreatic fibrosis (HP:0100732)3.26683130
20Abnormal rod and cone electroretinograms (HP:0008323)3.25714205
21Abnormality of midbrain morphology (HP:0002418)3.19767071
22Molar tooth sign on MRI (HP:0002419)3.19767071
233-Methylglutaconic aciduria (HP:0003535)3.12875501
24Pendular nystagmus (HP:0012043)3.08809547
25Increased intramyocellular lipid droplets (HP:0012240)3.08361378
26Optic disc pallor (HP:0000543)2.96860734
27Macrocytic anemia (HP:0001972)2.91913086
28True hermaphroditism (HP:0010459)2.91659578
29IgG deficiency (HP:0004315)2.86220463
30Elevated erythrocyte sedimentation rate (HP:0003565)2.86218977
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75742865
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75742865
33Decreased central vision (HP:0007663)2.72793410
34Increased serum lactate (HP:0002151)2.67399039
35Increased muscle lipid content (HP:0009058)2.61423096
36Abolished electroretinogram (ERG) (HP:0000550)2.56134260
37Absent/shortened dynein arms (HP:0200106)2.55278696
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.55278696
39Lactic acidosis (HP:0003128)2.54649426
40Type II lissencephaly (HP:0007260)2.51002013
41Exertional dyspnea (HP:0002875)2.50828656
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46753030
43Pallor (HP:0000980)2.44880326
44Absent thumb (HP:0009777)2.41036956
45Stomatitis (HP:0010280)2.38835210
46Attenuation of retinal blood vessels (HP:0007843)2.38403202
47Nephronophthisis (HP:0000090)2.36741617
48Increased corneal curvature (HP:0100692)2.35839595
49Keratoconus (HP:0000563)2.35839595
50Abnormality of renal resorption (HP:0011038)2.35289263
51Sclerocornea (HP:0000647)2.31559331
52Respiratory failure (HP:0002878)2.25445419
53Increased IgM level (HP:0003496)2.24561131
54Medial flaring of the eyebrow (HP:0010747)2.24518976
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24417106
56Leukodystrophy (HP:0002415)2.18517502
57Lethargy (HP:0001254)2.18061375
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15411915
59Congenital, generalized hypertrichosis (HP:0004540)2.13525182
60Aplastic anemia (HP:0001915)2.13485503
61Chronic hepatic failure (HP:0100626)2.12963688
62Cystic liver disease (HP:0006706)2.12895655
63Abnormality of alanine metabolism (HP:0010916)2.10241019
64Hyperalaninemia (HP:0003348)2.10241019
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10241019
66Abnormality of B cell number (HP:0010975)2.09287234
67Abnormality of urine glucose concentration (HP:0011016)2.08461926
68Glycosuria (HP:0003076)2.08461926
69Anencephaly (HP:0002323)2.06047122
70Exercise intolerance (HP:0003546)2.06014188
71Aplasia/Hypoplasia of the spleen (HP:0010451)2.01244310
72Type 2 muscle fiber atrophy (HP:0003554)1.98000270
73Abnormal respiratory motile cilium morphology (HP:0005938)1.97424379
74Abnormal respiratory epithelium morphology (HP:0012253)1.97424379
75Abnormality of the renal medulla (HP:0100957)1.95478768
76Hyperphosphaturia (HP:0003109)1.94029410
77Abnormality of the renal cortex (HP:0011035)1.93945993
78Asplenia (HP:0001746)1.92144651
79Constricted visual fields (HP:0001133)1.90285767
80Stenosis of the external auditory canal (HP:0000402)1.85774271
81Hypoproteinemia (HP:0003075)1.84230264
82Abnormal drinking behavior (HP:0030082)1.83732220
83Polydipsia (HP:0001959)1.83732220
84Colon cancer (HP:0003003)1.80871171
85Hyperglycinemia (HP:0002154)1.80799389
86Respiratory difficulties (HP:0002880)1.79677940
87Abnormality of DNA repair (HP:0003254)1.77439866
88Abnormal ciliary motility (HP:0012262)1.77063392
89Severe combined immunodeficiency (HP:0004430)1.75912957
90Concave nail (HP:0001598)1.73088262
91Muscle fiber atrophy (HP:0100295)1.71045788
92Postaxial foot polydactyly (HP:0001830)1.67604727
93Septo-optic dysplasia (HP:0100842)1.66289247
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65996145
95Abnormality of the prostate (HP:0008775)1.65209854
96Agitation (HP:0000713)1.65109232
97Aplasia/hypoplasia of the uterus (HP:0008684)1.63441356
98X-linked dominant inheritance (HP:0001423)1.62871293
99Male pseudohermaphroditism (HP:0000037)1.61320206
100Myokymia (HP:0002411)1.60479726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.42402309
2TLK12.86965151
3STK162.83961090
4VRK22.83733099
5WNK42.82967596
6NUAK12.78574348
7TAOK32.71760374
8ADRBK22.67956694
9ZAK2.65451440
10BCKDK2.52142499
11KDR2.35436109
12MAP4K22.32002093
13GRK12.12062808
14PASK2.05923304
15PINK11.92926025
16MAP4K11.80006407
17CDK191.74907420
18TIE11.73638057
19DYRK21.60161815
20FRK1.59769891
21CAMKK21.50968167
22BMPR1B1.49192233
23VRK11.45006235
24STK391.42908878
25WNK31.39186378
26TEC1.31434861
27MAP3K121.31212379
28ITK1.27383149
29TNIK1.26169305
30CAMKK11.24653625
31PRKCQ1.19765699
32OXSR11.18027610
33NME21.17556010
34TESK21.16416439
35IKBKB1.08787701
36SYK0.95149065
37GRK60.95115080
38MAPK130.90910098
39INSRR0.90757641
40MAP3K110.88198192
41RPS6KA50.86513160
42BTK0.86090527
43NME10.81884686
44CDK80.79528964
45KIT0.79102281
46LRRK20.78941800
47PIK3CA0.78209448
48ADRBK10.76718908
49LCK0.75191784
50MUSK0.73926618
51DAPK10.73131711
52MAP2K70.71454732
53MAP3K40.69389359
54BMPR20.69290709
55FES0.69107950
56PHKG10.69032509
57PHKG20.69032509
58PRKCG0.68834634
59MYLK0.66598835
60LIMK10.66311429
61CSNK1G30.64417701
62IKBKE0.63403908
63DAPK30.60611240
64LYN0.60011204
65CSNK1G20.59737658
66CAMK10.59361999
67PLK40.57982946
68PRKACA0.54719812
69CSNK2A20.51836124
70GRK70.49845702
71MAPKAPK30.49119768
72OBSCN0.48904548
73PRKCA0.46948369
74ABL20.46666846
75NTRK20.45675592
76PIM20.45230362
77DAPK20.44340693
78CSNK2A10.43017599
79PDK20.42783760
80GRK50.42265086
81TNK20.42219752
82MAPKAPK50.41470451
83WNK10.40608661
84BUB10.40184969
85AURKA0.40083068
86PRKCD0.38816682
87CSNK1A10.38622275
88PRKCI0.38525844
89RIPK40.38305319
90PIM10.38244794
91CSNK1G10.37892467
92RPS6KA60.37596871
93CSF1R0.37023865
94AURKB0.36835321
95PAK30.35752416
96IGF1R0.34756089
97PRKCE0.34679637
98ACVR1B0.33572369
99CSNK1A1L0.33552686
100PLK20.33276364

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.16229092
2Oxidative phosphorylation_Homo sapiens_hsa001904.10346116
3Parkinsons disease_Homo sapiens_hsa050123.43095311
4Proteasome_Homo sapiens_hsa030503.12974171
5Asthma_Homo sapiens_hsa053102.99421828
6Allograft rejection_Homo sapiens_hsa053302.47131111
7Autoimmune thyroid disease_Homo sapiens_hsa053202.39763285
8RNA polymerase_Homo sapiens_hsa030202.39075086
9Primary immunodeficiency_Homo sapiens_hsa053402.35965448
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.35334361
11Alzheimers disease_Homo sapiens_hsa050102.26100533
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25837696
13Graft-versus-host disease_Homo sapiens_hsa053322.22410046
14Huntingtons disease_Homo sapiens_hsa050162.20878208
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12583291
16Protein export_Homo sapiens_hsa030601.96473231
17Cardiac muscle contraction_Homo sapiens_hsa042601.95855038
18Type I diabetes mellitus_Homo sapiens_hsa049401.89839285
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89700235
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70848801
21Linoleic acid metabolism_Homo sapiens_hsa005911.60491976
22Homologous recombination_Homo sapiens_hsa034401.45548868
23Phototransduction_Homo sapiens_hsa047441.39375712
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37274283
25Antigen processing and presentation_Homo sapiens_hsa046121.32902500
26RNA degradation_Homo sapiens_hsa030181.32109509
27Pyrimidine metabolism_Homo sapiens_hsa002401.26180273
28One carbon pool by folate_Homo sapiens_hsa006701.22564976
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16375253
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13427598
31Rheumatoid arthritis_Homo sapiens_hsa053231.13374420
32Nitrogen metabolism_Homo sapiens_hsa009101.13009380
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11418713
34Caffeine metabolism_Homo sapiens_hsa002321.11359995
35Basal transcription factors_Homo sapiens_hsa030221.07105046
36Sulfur relay system_Homo sapiens_hsa041220.99951274
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96543330
38Hematopoietic cell lineage_Homo sapiens_hsa046400.93655501
39Fanconi anemia pathway_Homo sapiens_hsa034600.92705966
40Nucleotide excision repair_Homo sapiens_hsa034200.91404771
41Purine metabolism_Homo sapiens_hsa002300.89270777
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86129762
43Peroxisome_Homo sapiens_hsa041460.83014963
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80983118
45Tryptophan metabolism_Homo sapiens_hsa003800.80770030
46Nicotine addiction_Homo sapiens_hsa050330.78287507
47Arachidonic acid metabolism_Homo sapiens_hsa005900.76589428
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76111918
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75895020
50DNA replication_Homo sapiens_hsa030300.72842285
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71897008
52Mismatch repair_Homo sapiens_hsa034300.71309554
53Chemical carcinogenesis_Homo sapiens_hsa052040.70948032
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70024898
55Butanoate metabolism_Homo sapiens_hsa006500.69589949
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68207681
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.67690078
58Base excision repair_Homo sapiens_hsa034100.67285475
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67258510
60Propanoate metabolism_Homo sapiens_hsa006400.65758057
61Fat digestion and absorption_Homo sapiens_hsa049750.65627909
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65317406
63Retinol metabolism_Homo sapiens_hsa008300.64648338
64Olfactory transduction_Homo sapiens_hsa047400.64290022
65Metabolic pathways_Homo sapiens_hsa011000.63113572
66Viral myocarditis_Homo sapiens_hsa054160.61898675
67Systemic lupus erythematosus_Homo sapiens_hsa053220.60026553
68T cell receptor signaling pathway_Homo sapiens_hsa046600.57981805
69Regulation of autophagy_Homo sapiens_hsa041400.57836964
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57515801
71Ether lipid metabolism_Homo sapiens_hsa005650.57378441
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56893704
73Sulfur metabolism_Homo sapiens_hsa009200.55927364
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55534195
75Spliceosome_Homo sapiens_hsa030400.54330143
76Collecting duct acid secretion_Homo sapiens_hsa049660.54067125
77Staphylococcus aureus infection_Homo sapiens_hsa051500.53071071
78RNA transport_Homo sapiens_hsa030130.51137837
79Morphine addiction_Homo sapiens_hsa050320.48895576
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47959221
81Selenocompound metabolism_Homo sapiens_hsa004500.46734385
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.45414467
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.44788566
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44218433
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41518629
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.41224136
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39204925
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38314910
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.38051844
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36961658
91Taste transduction_Homo sapiens_hsa047420.35381702
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29082716
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.26255874
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22420775
95Serotonergic synapse_Homo sapiens_hsa047260.20719072
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19989470
97Glycerolipid metabolism_Homo sapiens_hsa005610.18837417
98Vitamin digestion and absorption_Homo sapiens_hsa049770.18261687
99Tyrosine metabolism_Homo sapiens_hsa003500.15693478
100Folate biosynthesis_Homo sapiens_hsa007900.15125574

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