RPS17P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)8.84368802
2ribosomal small subunit assembly (GO:0000028)8.75355477
3viral transcription (GO:0019083)8.14460725
4ribosomal small subunit biogenesis (GO:0042274)7.96191935
5translational termination (GO:0006415)7.82427825
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.76311829
7cotranslational protein targeting to membrane (GO:0006613)6.71293160
8translational elongation (GO:0006414)6.70563301
9protein targeting to ER (GO:0045047)6.61490857
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.31272098
11protein localization to endoplasmic reticulum (GO:0070972)6.23485796
12cellular protein complex disassembly (GO:0043624)5.92306436
13viral life cycle (GO:0019058)5.88260389
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.79869373
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.27065758
16ATP synthesis coupled proton transport (GO:0015986)5.27065758
17translational initiation (GO:0006413)5.09473534
18protein complex disassembly (GO:0043241)4.93895337
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.93221442
20macromolecular complex disassembly (GO:0032984)4.77768400
21ribosomal large subunit biogenesis (GO:0042273)4.73467848
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63670634
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.45152130
24protein targeting to membrane (GO:0006612)4.40698549
25chaperone-mediated protein transport (GO:0072321)4.35189029
26respiratory electron transport chain (GO:0022904)4.33751088
27electron transport chain (GO:0022900)4.28172577
28translation (GO:0006412)4.22415103
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.18768334
30DNA deamination (GO:0045006)4.15336376
31protein complex biogenesis (GO:0070271)3.95067253
32mRNA catabolic process (GO:0006402)3.95032209
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.94792169
34gonadal mesoderm development (GO:0007506)3.83871717
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80878555
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80878555
37base-excision repair, AP site formation (GO:0006285)3.76495869
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.70290550
39substrate-independent telencephalic tangential migration (GO:0021826)3.70290550
40ribonucleoprotein complex biogenesis (GO:0022613)3.66680060
41protein neddylation (GO:0045116)3.64705009
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.60765996
43NADH dehydrogenase complex assembly (GO:0010257)3.60765996
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60765996
45ubiquinone biosynthetic process (GO:0006744)3.58357923
46RNA catabolic process (GO:0006401)3.56979637
47nonmotile primary cilium assembly (GO:0035058)3.55762571
48protein-cofactor linkage (GO:0018065)3.53531709
49cellular component biogenesis (GO:0044085)3.51990267
50mitochondrial respiratory chain complex assembly (GO:0033108)3.46962381
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.45264810
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45003773
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40972716
54behavioral response to nicotine (GO:0035095)3.38258609
55pyrimidine nucleotide catabolic process (GO:0006244)3.35966982
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27697827
57negative regulation of telomere maintenance (GO:0032205)3.27427473
58hydrogen ion transmembrane transport (GO:1902600)3.22481735
59ubiquinone metabolic process (GO:0006743)3.20805751
60ATP biosynthetic process (GO:0006754)3.11225575
61quinone biosynthetic process (GO:1901663)3.07727551
62proton transport (GO:0015992)3.04198228
63metallo-sulfur cluster assembly (GO:0031163)3.03955631
64iron-sulfur cluster assembly (GO:0016226)3.03955631
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03312846
66establishment of protein localization to membrane (GO:0090150)3.00215774
67hydrogen transport (GO:0006818)2.98532291
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96566428
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95806002
70protein targeting (GO:0006605)2.89110688
71ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81023998
72GTP biosynthetic process (GO:0006183)2.78255873
73deoxyribose phosphate catabolic process (GO:0046386)2.77540162
74deoxyribonucleotide catabolic process (GO:0009264)2.75118124
75regulation of cellular respiration (GO:0043457)2.73638013
76negative regulation of appetite (GO:0032099)2.68849199
77negative regulation of response to food (GO:0032096)2.68849199
78establishment of protein localization to organelle (GO:0072594)2.66704045
79ribonucleoprotein complex disassembly (GO:0032988)2.66505526
80negative regulation of mast cell activation (GO:0033004)2.66292744
81cell proliferation in forebrain (GO:0021846)2.64641961
82water-soluble vitamin biosynthetic process (GO:0042364)2.61238789
83somite development (GO:0061053)2.60733337
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60454373
85negative regulation of T cell differentiation in thymus (GO:0033085)2.60452244
86positive regulation of respiratory burst (GO:0060267)2.57735887
87intracellular protein transmembrane import (GO:0044743)2.54707056
88negative regulation of DNA-templated transcription, elongation (GO:0032785)2.54447778
89CTP metabolic process (GO:0046036)2.53669258
90CTP biosynthetic process (GO:0006241)2.53669258
91protein polyglutamylation (GO:0018095)2.53611525
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.53509155
93peptidyl-histidine modification (GO:0018202)2.53046610
94regulation of cilium movement (GO:0003352)2.52957565
95pseudouridine synthesis (GO:0001522)2.52506809
96male meiosis I (GO:0007141)2.51783149
97platelet dense granule organization (GO:0060155)2.48796676
98rRNA processing (GO:0006364)2.48378641
99cardiovascular system development (GO:0072358)2.47490433
100neuron fate determination (GO:0048664)2.45024407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58190243
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.17316504
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.06960789
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48311047
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01849744
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95970851
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95814790
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.78169535
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.73855197
10VDR_22108803_ChIP-Seq_LS180_Human2.40455697
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32456360
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29776944
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10284364
14MYC_18940864_ChIP-ChIP_HL60_Human2.10110330
15VDR_23849224_ChIP-Seq_CD4+_Human2.02451131
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.01192745
17ELK1_19687146_ChIP-ChIP_HELA_Human1.89751315
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89695694
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74232107
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67607383
21TTF2_22483619_ChIP-Seq_HELA_Human1.66434577
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63946912
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59052577
24TP53_22573176_ChIP-Seq_HFKS_Human1.57420959
25FOXP3_21729870_ChIP-Seq_TREG_Human1.56604118
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.56038480
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.55906998
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52887188
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48627583
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43348797
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41062857
32IGF1R_20145208_ChIP-Seq_DFB_Human1.40551913
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39645947
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.38034522
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.35697209
36GATA3_21878914_ChIP-Seq_MCF-7_Human1.35378549
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.34704090
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33600312
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32557965
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28960565
41FUS_26573619_Chip-Seq_HEK293_Human1.28831898
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28295087
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28137971
44XRN2_22483619_ChIP-Seq_HELA_Human1.28097251
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27790736
46AR_20517297_ChIP-Seq_VCAP_Human1.27739622
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26216091
48EWS_26573619_Chip-Seq_HEK293_Human1.23292483
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21464431
50NCOR_22424771_ChIP-Seq_293T_Human1.21031304
51NANOG_20526341_ChIP-Seq_ESCs_Human1.20621652
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20408469
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16819729
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15621343
55RNF2_27304074_Chip-Seq_NSC_Mouse1.15420766
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13843400
57GABP_19822575_ChIP-Seq_HepG2_Human1.13262501
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.13115755
59PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13011557
60BCL6_27268052_Chip-Seq_Bcells_Human1.11950009
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11315873
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.10456871
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08795074
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08438904
65TAF2_19829295_ChIP-Seq_ESCs_Human1.05744645
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05443289
67CTCF_20526341_ChIP-Seq_ESCs_Human1.05021038
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04904453
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04227805
70GATA3_21867929_ChIP-Seq_TH1_Mouse1.03650422
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.03322335
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03322335
73P53_21459846_ChIP-Seq_SAOS-2_Human1.02211793
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.01497436
75ERA_21632823_ChIP-Seq_H3396_Human1.00885367
76CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98423784
77YY1_21170310_ChIP-Seq_MESCs_Mouse0.98245963
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98208254
79HOXB7_26014856_ChIP-Seq_BT474_Human0.98199474
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.97599619
81MYC_19829295_ChIP-Seq_ESCs_Human0.96620418
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.95911389
83IRF1_19129219_ChIP-ChIP_H3396_Human0.95740835
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.94466436
85E2F1_20622854_ChIP-Seq_HELA_Human0.94281996
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93028272
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92165044
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.91387520
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.90729620
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89726960
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89007165
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87670832
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87615930
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85370667
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.85065709
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85004667
97MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84008715
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83369686
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82093975
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.80796335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.14592395
2MP0006292_abnormal_olfactory_placode3.67302881
3MP0002653_abnormal_ependyma_morphology2.93316343
4MP0002163_abnormal_gland_morphology2.90867445
5MP0008877_abnormal_DNA_methylation2.88838987
6MP0005645_abnormal_hypothalamus_physiol2.44964761
7MP0002160_abnormal_reproductive_system2.34602405
8MP0005646_abnormal_pituitary_gland2.21192130
9MP0003122_maternal_imprinting2.19735269
10MP0004142_abnormal_muscle_tone2.17906096
11MP0004147_increased_porphyrin_level2.04503985
12MP0005389_reproductive_system_phenotype2.00056903
13MP0003787_abnormal_imprinting1.99596331
14MP0008789_abnormal_olfactory_epithelium1.96525027
15MP0004885_abnormal_endolymph1.95577429
16MP0005379_endocrine/exocrine_gland_phen1.93615328
17MP0006072_abnormal_retinal_apoptosis1.88946293
18MP0006276_abnormal_autonomic_nervous1.85445164
19MP0002234_abnormal_pharynx_morphology1.78572129
20MP0005671_abnormal_response_to1.77524418
21MP0008995_early_reproductive_senescence1.71477569
22MP0002876_abnormal_thyroid_physiology1.67762814
23MP0001919_abnormal_reproductive_system1.62448432
24MP0003646_muscle_fatigue1.61613175
25MP0005377_hearing/vestibular/ear_phenot1.61490689
26MP0003878_abnormal_ear_physiology1.61490689
27MP0005551_abnormal_eye_electrophysiolog1.56200622
28MP0002837_dystrophic_cardiac_calcinosis1.55184072
29MP0001293_anophthalmia1.50749591
30MP0001905_abnormal_dopamine_level1.47289787
31MP0003121_genomic_imprinting1.45112839
32MP0008872_abnormal_physiological_respon1.44901431
33MP0005394_taste/olfaction_phenotype1.40982932
34MP0005499_abnormal_olfactory_system1.40982932
35MP0000631_abnormal_neuroendocrine_gland1.38764807
36MP0000516_abnormal_urinary_system1.38011917
37MP0005367_renal/urinary_system_phenotyp1.38011917
38MP0004145_abnormal_muscle_electrophysio1.34000839
39MP0001485_abnormal_pinna_reflex1.31935817
40MP0003136_yellow_coat_color1.27938973
41MP0008875_abnormal_xenobiotic_pharmacok1.25980581
42MP0000049_abnormal_middle_ear1.21626832
43MP0002736_abnormal_nociception_after1.20411730
44MP0001986_abnormal_taste_sensitivity1.18301571
45MP0003186_abnormal_redox_activity1.17149458
46MP0009745_abnormal_behavioral_response1.15368406
47MP0003786_premature_aging1.13557989
48MP0003315_abnormal_perineum_morphology1.11109617
49MP0000372_irregular_coat_pigmentation1.10679913
50MP0005670_abnormal_white_adipose1.10604372
51MP0000778_abnormal_nervous_system1.10537821
52MP0003880_abnormal_central_pattern1.10471078
53MP0004133_heterotaxia1.10238400
54MP0003195_calcinosis1.10098692
55MP0002095_abnormal_skin_pigmentation1.10001950
56MP0000427_abnormal_hair_cycle1.09293976
57MP0001968_abnormal_touch/_nociception1.06398605
58MP0008775_abnormal_heart_ventricle1.05207152
59MP0005195_abnormal_posterior_eye1.03999766
60MP0001440_abnormal_grooming_behavior1.02653702
61MP0001348_abnormal_lacrimal_gland1.01751464
62MP0002733_abnormal_thermal_nociception1.01040462
63MP0006036_abnormal_mitochondrial_physio1.00548994
64MP0002272_abnormal_nervous_system0.97975729
65MP0003942_abnormal_urinary_system0.95212734
66MP0009764_decreased_sensitivity_to0.94128088
67MP0004043_abnormal_pH_regulation0.94028375
68MP0001970_abnormal_pain_threshold0.91531328
69MP0002928_abnormal_bile_duct0.91446161
70MP0005423_abnormal_somatic_nervous0.91006331
71MP0003879_abnormal_hair_cell0.89513353
72MP0001529_abnormal_vocalization0.88495119
73MP0000026_abnormal_inner_ear0.88376290
74MP0002184_abnormal_innervation0.87889043
75MP0002102_abnormal_ear_morphology0.87716511
76MP0001486_abnormal_startle_reflex0.85253190
77MP0001963_abnormal_hearing_physiology0.85193019
78MP0006035_abnormal_mitochondrial_morpho0.84217471
79MP0001727_abnormal_embryo_implantation0.83268831
80MP0003806_abnormal_nucleotide_metabolis0.82705368
81MP0002210_abnormal_sex_determination0.82508046
82MP0003123_paternal_imprinting0.82224413
83MP0005253_abnormal_eye_physiology0.82121632
84MP0002752_abnormal_somatic_nervous0.80629772
85MP0005636_abnormal_mineral_homeostasis0.79863778
86MP0000955_abnormal_spinal_cord0.79857321
87MP0000613_abnormal_salivary_gland0.79776840
88MP0009046_muscle_twitch0.79350195
89MP0001984_abnormal_olfaction0.78458205
90MP0005360_urolithiasis0.76647872
91MP0002277_abnormal_respiratory_mucosa0.76260707
92MP0002938_white_spotting0.74226947
93MP0000230_abnormal_systemic_arterial0.70726277
94MP0002557_abnormal_social/conspecific_i0.70251278
95MP0001145_abnormal_male_reproductive0.69887387
96MP0004742_abnormal_vestibular_system0.68546426
97MP0002132_abnormal_respiratory_system0.68040152
98MP0001765_abnormal_ion_homeostasis0.67776006
99MP0005084_abnormal_gallbladder_morpholo0.67328301
100MP0004019_abnormal_vitamin_homeostasis0.65980456

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.49896157
2Abnormality of cells of the erythroid lineage (HP:0012130)5.96809718
3Abnormal number of erythroid precursors (HP:0012131)4.89323735
4Macrocytic anemia (HP:0001972)3.93359887
53-Methylglutaconic aciduria (HP:0003535)3.77249146
6Abnormality of B cell number (HP:0010975)3.77041281
7Molar tooth sign on MRI (HP:0002419)3.69305255
8Abnormality of midbrain morphology (HP:0002418)3.69305255
9Acute necrotizing encephalopathy (HP:0006965)3.59918568
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.45781625
11Abnormal mitochondria in muscle tissue (HP:0008316)3.36113398
12Mitochondrial inheritance (HP:0001427)3.35413927
13Pancreatic fibrosis (HP:0100732)3.33973721
14Congenital stationary night blindness (HP:0007642)3.19961548
15Pallor (HP:0000980)3.14741456
16Acute encephalopathy (HP:0006846)3.13963418
17Absent thumb (HP:0009777)3.11249982
18True hermaphroditism (HP:0010459)3.07789980
19Septo-optic dysplasia (HP:0100842)3.06134309
20Increased CSF lactate (HP:0002490)2.95875671
21Hepatocellular necrosis (HP:0001404)2.92855484
22Hepatic necrosis (HP:0002605)2.90190724
23Pancreatic cysts (HP:0001737)2.88583409
24Progressive macrocephaly (HP:0004481)2.88209437
25Colon cancer (HP:0003003)2.86149975
26Medial flaring of the eyebrow (HP:0010747)2.85431348
27B lymphocytopenia (HP:0010976)2.81177007
28Nephronophthisis (HP:0000090)2.79748342
29Stenosis of the external auditory canal (HP:0000402)2.79320835
30Type II lissencephaly (HP:0007260)2.76375441
31Panhypogammaglobulinemia (HP:0003139)2.75803785
32Elevated erythrocyte sedimentation rate (HP:0003565)2.71578882
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.65455904
34Abnormal rod and cone electroretinograms (HP:0008323)2.63840215
35Severe combined immunodeficiency (HP:0004430)2.63797527
36Myokymia (HP:0002411)2.62773509
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59343346
38Asplenia (HP:0001746)2.56545071
39Pendular nystagmus (HP:0012043)2.55174863
40Abolished electroretinogram (ERG) (HP:0000550)2.47648079
41Thyroiditis (HP:0100646)2.46799997
42Sclerocornea (HP:0000647)2.35461064
43IgG deficiency (HP:0004315)2.34827709
44Abnormality of the renal medulla (HP:0100957)2.33460064
45Abnormality of DNA repair (HP:0003254)2.28576889
46Gait imbalance (HP:0002141)2.27730320
47Postaxial foot polydactyly (HP:0001830)2.26181797
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.24357068
49Absent/shortened dynein arms (HP:0200106)2.24357068
50Hypoplasia of the thymus (HP:0000778)2.21626684
51Renal cortical cysts (HP:0000803)2.19368056
52Abnormality of the renal cortex (HP:0011035)2.18690693
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18604298
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18604298
55Male pseudohermaphroditism (HP:0000037)2.18252821
56Congenital primary aphakia (HP:0007707)2.17975163
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14211229
58Increased serum lactate (HP:0002151)2.13380252
59Cerebral edema (HP:0002181)2.11319869
60Stomach cancer (HP:0012126)2.10873399
61Increased IgM level (HP:0003496)2.10365816
62Erythroderma (HP:0001019)2.07129136
63Optic disc pallor (HP:0000543)2.05832585
64Hypoproteinemia (HP:0003075)2.05622589
65Abnormality of reticulocytes (HP:0004312)2.05133612
66Abnormal respiratory motile cilium physiology (HP:0012261)2.03824655
67Lactic acidosis (HP:0003128)2.02737894
68Absent septum pellucidum (HP:0001331)2.02630958
69Optic nerve hypoplasia (HP:0000609)2.01757672
70Delayed CNS myelination (HP:0002188)2.01648888
71Abnormal ciliary motility (HP:0012262)2.00510838
72Nephrogenic diabetes insipidus (HP:0009806)2.00466352
73Cystic liver disease (HP:0006706)1.95093665
74Rib fusion (HP:0000902)1.94603722
75Eosinophilia (HP:0001880)1.94335558
76Combined immunodeficiency (HP:0005387)1.93801889
77Generalized aminoaciduria (HP:0002909)1.90716010
78Respiratory failure (HP:0002878)1.90520235
79Abnormal respiratory motile cilium morphology (HP:0005938)1.88551032
80Abnormal respiratory epithelium morphology (HP:0012253)1.88551032
81Type 2 muscle fiber atrophy (HP:0003554)1.88063887
82Depressed nasal ridge (HP:0000457)1.86758529
83Abnormality of T cell number (HP:0011839)1.81487370
84Hypoplasia of the radius (HP:0002984)1.81331514
85Increased intramyocellular lipid droplets (HP:0012240)1.80165071
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79283132
87Abnormal hemoglobin (HP:0011902)1.78969650
88Agitation (HP:0000713)1.75742705
89Abnormality of eosinophils (HP:0001879)1.75265970
90Anencephaly (HP:0002323)1.74799328
91Horseshoe kidney (HP:0000085)1.73506657
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.73221493
93Muscle fiber atrophy (HP:0100295)1.71464901
94Lipid accumulation in hepatocytes (HP:0006561)1.71025468
95Increased hepatocellular lipid droplets (HP:0006565)1.70761923
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.69005097
97Abnormality of T cells (HP:0002843)1.66834553
98Genital tract atresia (HP:0001827)1.66723996
99Lethargy (HP:0001254)1.65646659
100Vaginal atresia (HP:0000148)1.65483140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.58442327
2CDK193.52005384
3MAP4K23.15549489
4TXK2.95568037
5ZAK2.92914429
6PINK12.83942381
7STK162.46441851
8TESK22.43405750
9GRK12.32253373
10ADRBK22.21731047
11FRK2.09893136
12STK392.07255980
13CAMKK22.02004677
14TIE11.95799763
15MUSK1.90285755
16TLK11.82180628
17NME21.58668991
18DYRK21.57061261
19VRK21.49472904
20PASK1.41527664
21PIK3CA1.40500562
22PIM21.37379751
23KDR1.34356372
24BCKDK1.26908188
25PLK41.20344075
26NUAK11.11272898
27NME11.08512627
28CAMKK11.07887349
29BMPR1B1.06992504
30ARAF1.06309016
31LRRK21.05272639
32LIMK11.03164286
33ABL21.03155267
34EPHB21.02493099
35INSRR0.95650247
36PLK20.94278557
37PRKD30.93721489
38CAMK10.93642705
39MOS0.91758184
40MAPK130.87681217
41CDK80.85126806
42RPS6KA60.83689166
43PRKCQ0.83300015
44AURKA0.82264788
45PAK30.81718176
46IKBKB0.78758693
47MAP3K120.75665140
48PRKCG0.74950914
49PHKG10.74783270
50PHKG20.74783270
51RPS6KC10.70991244
52RPS6KL10.70991244
53MAP3K90.69240617
54MYLK0.67137201
55OXSR10.66928504
56BUB10.66658274
57DAPK30.66490462
58PRKCH0.64322788
59RPS6KA50.62617556
60FES0.62236130
61PRKACA0.62148003
62CSNK2A20.61207945
63MAP3K40.60028767
64BRAF0.59349287
65ATR0.58966227
66ILK0.58738897
67NTRK30.56800068
68CHEK20.55999497
69CSNK1G30.55751900
70RPS6KA40.55441546
71IRAK40.55249530
72CSNK1G20.54961377
73VRK10.54689938
74CSNK2A10.54683053
75ADRBK10.54600397
76MATK0.54042028
77WNK10.53333855
78NTRK20.53276542
79SRPK10.53114674
80PRKCI0.53101562
81AURKB0.52904906
82PIM10.51162871
83GRK70.50489892
84CSNK1A10.50357637
85TYRO30.47800215
86MAP2K20.47280201
87PLK10.47054997
88PAK60.46784352
89ERBB20.46543496
90LYN0.46270970
91DAPK20.46076648
92CDK30.45582055
93RPS6KA20.44617099
94PRKCA0.43177827
95CDC70.42712044
96CDK11A0.42337661
97OBSCN0.42083870
98CSNK1E0.41290848
99NEK10.41055752
100PRKCD0.40557264

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.67999310
2Oxidative phosphorylation_Homo sapiens_hsa001904.62879328
3Parkinsons disease_Homo sapiens_hsa050123.66268559
4Alzheimers disease_Homo sapiens_hsa050102.77879210
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.72171379
6Cardiac muscle contraction_Homo sapiens_hsa042602.69987192
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58948451
8Huntingtons disease_Homo sapiens_hsa050162.53610258
9Proteasome_Homo sapiens_hsa030502.16946387
10Protein export_Homo sapiens_hsa030602.12605851
11Homologous recombination_Homo sapiens_hsa034402.06338007
12Primary immunodeficiency_Homo sapiens_hsa053401.95574234
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89425086
14RNA polymerase_Homo sapiens_hsa030201.78330339
15Fanconi anemia pathway_Homo sapiens_hsa034601.70128401
16Linoleic acid metabolism_Homo sapiens_hsa005911.66915932
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61119435
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53437926
19RNA degradation_Homo sapiens_hsa030181.53247839
20Asthma_Homo sapiens_hsa053101.31760736
21Phototransduction_Homo sapiens_hsa047441.30283457
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24325624
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.24189858
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22688097
25Sulfur relay system_Homo sapiens_hsa041221.15022337
26Nitrogen metabolism_Homo sapiens_hsa009101.13732752
27Graft-versus-host disease_Homo sapiens_hsa053321.13375494
28Allograft rejection_Homo sapiens_hsa053301.13354541
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09158915
30Caffeine metabolism_Homo sapiens_hsa002321.08360814
31Autoimmune thyroid disease_Homo sapiens_hsa053201.06460853
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04691115
33Butanoate metabolism_Homo sapiens_hsa006501.04514136
34Pyrimidine metabolism_Homo sapiens_hsa002401.02237850
35Chemical carcinogenesis_Homo sapiens_hsa052041.00743578
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96586986
37Type I diabetes mellitus_Homo sapiens_hsa049400.91621232
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89685736
39Antigen processing and presentation_Homo sapiens_hsa046120.86899718
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86446056
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85831645
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85814996
43Tryptophan metabolism_Homo sapiens_hsa003800.84702191
44Nicotine addiction_Homo sapiens_hsa050330.83976936
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.83285777
46Steroid biosynthesis_Homo sapiens_hsa001000.81399606
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.79729272
48Basal transcription factors_Homo sapiens_hsa030220.79486797
49Arachidonic acid metabolism_Homo sapiens_hsa005900.76467445
50Fatty acid elongation_Homo sapiens_hsa000620.76248581
51Metabolic pathways_Homo sapiens_hsa011000.75657364
52Peroxisome_Homo sapiens_hsa041460.75108636
53Nucleotide excision repair_Homo sapiens_hsa034200.74315901
54Mismatch repair_Homo sapiens_hsa034300.74190922
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73684477
56Olfactory transduction_Homo sapiens_hsa047400.72734444
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72597966
58Propanoate metabolism_Homo sapiens_hsa006400.72089589
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71992401
60One carbon pool by folate_Homo sapiens_hsa006700.71901053
61Fat digestion and absorption_Homo sapiens_hsa049750.70590639
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69379717
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69067714
64Spliceosome_Homo sapiens_hsa030400.68656018
65Retinol metabolism_Homo sapiens_hsa008300.68156792
66Collecting duct acid secretion_Homo sapiens_hsa049660.68063409
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64797691
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63235677
69Fatty acid degradation_Homo sapiens_hsa000710.62676853
70Base excision repair_Homo sapiens_hsa034100.60275890
71Sulfur metabolism_Homo sapiens_hsa009200.59955653
72Rheumatoid arthritis_Homo sapiens_hsa053230.56823402
73Ether lipid metabolism_Homo sapiens_hsa005650.54864820
74Arginine and proline metabolism_Homo sapiens_hsa003300.54138129
75Morphine addiction_Homo sapiens_hsa050320.53136774
76beta-Alanine metabolism_Homo sapiens_hsa004100.48716908
77RNA transport_Homo sapiens_hsa030130.47507364
78DNA replication_Homo sapiens_hsa030300.47350611
79Hematopoietic cell lineage_Homo sapiens_hsa046400.43856652
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43662856
81Purine metabolism_Homo sapiens_hsa002300.42576064
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39198172
83Glycerolipid metabolism_Homo sapiens_hsa005610.36795184
84Regulation of autophagy_Homo sapiens_hsa041400.35451961
85Pyruvate metabolism_Homo sapiens_hsa006200.34830807
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.33609400
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32822104
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32649700
89GABAergic synapse_Homo sapiens_hsa047270.28753437
90Glutathione metabolism_Homo sapiens_hsa004800.27955262
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.25977207
92Salivary secretion_Homo sapiens_hsa049700.23507728
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22617106
94Fatty acid metabolism_Homo sapiens_hsa012120.22309802
95Starch and sucrose metabolism_Homo sapiens_hsa005000.22081396
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22030674
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21520263
98Taste transduction_Homo sapiens_hsa047420.21450517
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20153458
100p53 signaling pathway_Homo sapiens_hsa041150.19745938

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