RPS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational termination (GO:0006415)9.66323622
2ribosomal small subunit assembly (GO:0000028)9.15218749
3* ribosomal small subunit biogenesis (GO:0042274)8.61540853
4* translational elongation (GO:0006414)8.18403157
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.15750215
6* cotranslational protein targeting to membrane (GO:0006613)7.99861581
7* protein targeting to ER (GO:0045047)7.99829405
8* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.63858318
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.48815127
10* protein localization to endoplasmic reticulum (GO:0070972)7.48289179
11* cellular protein complex disassembly (GO:0043624)7.46029587
12* viral life cycle (GO:0019058)7.45796909
13maturation of SSU-rRNA (GO:0030490)7.18722922
14* translational initiation (GO:0006413)7.04460604
15* protein complex disassembly (GO:0043241)6.53291775
16ribosomal large subunit biogenesis (GO:0042273)6.40290003
17* macromolecular complex disassembly (GO:0032984)6.10010241
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.31268611
19* protein targeting to membrane (GO:0006612)5.30497200
20* translation (GO:0006412)5.05701159
21* mRNA catabolic process (GO:0006402)5.04817771
22* ribonucleoprotein complex biogenesis (GO:0022613)4.85416537
23DNA deamination (GO:0045006)4.71454608
24* RNA catabolic process (GO:0006401)4.71225603
25formation of translation preinitiation complex (GO:0001731)3.96366715
26* rRNA processing (GO:0006364)3.93706598
27DNA strand elongation involved in DNA replication (GO:0006271)3.90772156
28respiratory electron transport chain (GO:0022904)3.82236068
29* rRNA metabolic process (GO:0016072)3.78067623
30telomere maintenance via semi-conservative replication (GO:0032201)3.76925276
31chaperone-mediated protein transport (GO:0072321)3.75578091
32electron transport chain (GO:0022900)3.71380765
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.70817483
34DNA strand elongation (GO:0022616)3.70634294
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64788849
36* cellular component biogenesis (GO:0044085)3.62371317
37* establishment of protein localization to membrane (GO:0090150)3.56422241
38oxidative phosphorylation (GO:0006119)3.52547581
39heterochromatin organization (GO:0070828)3.32292342
40regulation of mitochondrial translation (GO:0070129)3.31157819
41* protein targeting (GO:0006605)3.29828755
42ncRNA 3-end processing (GO:0043628)3.29307285
43DNA replication initiation (GO:0006270)3.26257044
44negative regulation of DNA-templated transcription, elongation (GO:0032785)3.26174354
45spliceosomal snRNP assembly (GO:0000387)3.24799196
46* establishment of protein localization to organelle (GO:0072594)3.24174519
47telomere maintenance via recombination (GO:0000722)3.20639413
48negative regulation of RNA splicing (GO:0033119)3.16118620
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.13475739
50termination of RNA polymerase III transcription (GO:0006386)3.13475739
51protein targeting to mitochondrion (GO:0006626)3.11810853
52ATP biosynthetic process (GO:0006754)3.06352170
53spliceosomal complex assembly (GO:0000245)3.05346228
54pseudouridine synthesis (GO:0001522)3.03866958
55DNA unwinding involved in DNA replication (GO:0006268)3.02728342
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00479950
57ribosome biogenesis (GO:0042254)2.99787798
58telomere maintenance via telomere lengthening (GO:0010833)2.99283093
59purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96756832
60establishment of integrated proviral latency (GO:0075713)2.96717880
61mitotic chromosome condensation (GO:0007076)2.95472587
62establishment of protein localization to mitochondrion (GO:0072655)2.95010186
63mitotic recombination (GO:0006312)2.94889858
64ribonucleoside triphosphate biosynthetic process (GO:0009201)2.93994414
65proteasome assembly (GO:0043248)2.93736128
66pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87563859
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87392653
68guanosine-containing compound biosynthetic process (GO:1901070)2.87045475
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86964420
70regulation of translational fidelity (GO:0006450)2.82633591
71DNA replication checkpoint (GO:0000076)2.82417364
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.78345555
73protein localization to kinetochore (GO:0034501)2.74989282
74kinetochore assembly (GO:0051382)2.74944887
75protein localization to mitochondrion (GO:0070585)2.74881117
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73484572
77histone H2B ubiquitination (GO:0033523)2.73438401
78kinetochore organization (GO:0051383)2.73193772
79CENP-A containing nucleosome assembly (GO:0034080)2.72862801
80* ncRNA processing (GO:0034470)2.72529207
81* protein localization to membrane (GO:0072657)2.71148844
82* protein localization to organelle (GO:0033365)2.69678429
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69587126
84nucleobase-containing small molecule interconversion (GO:0015949)2.69479815
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.69348144
86UTP metabolic process (GO:0046051)2.68077656
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.67905818
88chromatin remodeling at centromere (GO:0031055)2.67707231
89pyrimidine nucleotide catabolic process (GO:0006244)2.67268623
90* gene expression (GO:0010467)2.64634696
91rRNA modification (GO:0000154)2.63782749
92positive regulation of viral transcription (GO:0050434)2.63729590
93UTP biosynthetic process (GO:0006228)2.62815249
94* cellular component disassembly (GO:0022411)2.61883984
95termination of RNA polymerase II transcription (GO:0006369)2.60295244
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.57976689
97aerobic respiration (GO:0009060)2.57892433
98transcription-coupled nucleotide-excision repair (GO:0006283)2.57673012
99RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57459034
100mRNA splicing, via spliceosome (GO:0000398)2.57459034
101RNA splicing, via transesterification reactions (GO:0000375)2.57078492
102ribonucleoprotein complex assembly (GO:0022618)2.56532347
103negative regulation of DNA repair (GO:0045738)2.56409608
1047-methylguanosine mRNA capping (GO:0006370)2.56220764
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54885456
106nucleoside triphosphate biosynthetic process (GO:0009142)2.54199010
107protein complex biogenesis (GO:0070271)2.53811041
108protein localization to chromosome, centromeric region (GO:0071459)2.53810677
109CTP metabolic process (GO:0046036)2.52971291
110CTP biosynthetic process (GO:0006241)2.52971291
111purine nucleoside monophosphate biosynthetic process (GO:0009127)2.52178805
112purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.52178805
113regulation of protein heterodimerization activity (GO:0043497)2.51962857
114NADH dehydrogenase complex assembly (GO:0010257)2.51827157
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51827157
116mitochondrial respiratory chain complex I assembly (GO:0032981)2.51827157
117GTP biosynthetic process (GO:0006183)2.51359806
118negative regulation of ligase activity (GO:0051352)2.51294716
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51294716
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50848149
121DNA-templated transcription, termination (GO:0006353)2.50519604
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50211683
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49377770
124* ncRNA metabolic process (GO:0034660)2.49259228
125DNA replication-independent nucleosome organization (GO:0034724)2.49225908
126DNA replication-independent nucleosome assembly (GO:0006336)2.49225908
127termination of RNA polymerase I transcription (GO:0006363)2.49112373
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48756221
129folic acid-containing compound biosynthetic process (GO:0009396)2.47899240
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47839324
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47335126
132nucleobase biosynthetic process (GO:0046112)2.47250283
133histone mRNA metabolic process (GO:0008334)2.45529032
134pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.45177027
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.42829699
136establishment of viral latency (GO:0019043)2.42397420
137pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42197694
138ribosome assembly (GO:0042255)2.41421971
139ribonucleoprotein complex subunit organization (GO:0071826)2.41220893
140ATP synthesis coupled proton transport (GO:0015986)2.40253132
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40253132
142* viral transcription (GO:0019083)10.0495674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.95210761
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.71110594
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39201819
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01261118
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.40413085
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.13999061
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.02095381
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95221943
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95002226
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.94554252
11XRN2_22483619_ChIP-Seq_HELA_Human2.81163000
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80226786
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.74249568
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72106677
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70544954
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67549299
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67240662
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62861225
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34643073
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29347453
21VDR_23849224_ChIP-Seq_CD4+_Human2.27007281
22TTF2_22483619_ChIP-Seq_HELA_Human2.21786233
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14053893
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12201640
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05855312
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.03203875
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01797230
28FOXP3_21729870_ChIP-Seq_TREG_Human2.01657875
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95042863
30MYC_22102868_ChIP-Seq_BL_Human1.92525808
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.87041202
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86845745
33VDR_21846776_ChIP-Seq_THP-1_Human1.73266329
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71308794
35ELK1_19687146_ChIP-ChIP_HELA_Human1.70270750
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69157201
37* GABP_19822575_ChIP-Seq_HepG2_Human1.67219055
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67001211
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65660419
40ZNF263_19887448_ChIP-Seq_K562_Human1.60575616
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54538723
42CIITA_25753668_ChIP-Seq_RAJI_Human1.53688607
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51498660
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.49861159
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49759967
46* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47879776
47LXR_22292898_ChIP-Seq_THP-1_Human1.46936281
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46260215
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45635043
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.45618358
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44359972
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43599708
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42608903
54* YY1_21170310_ChIP-Seq_MESCs_Mouse1.41171617
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40553199
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.38115349
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37409727
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36746244
59* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34335691
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32014773
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.29564480
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.29163352
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25277651
64SPI1_23547873_ChIP-Seq_NB4_Human1.24885514
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23661887
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22529749
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.22000610
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21916194
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.21294921
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21056293
71RACK7_27058665_Chip-Seq_MCF-7_Human1.20745513
72KDM5A_27292631_Chip-Seq_BREAST_Human1.20059290
73AR_21909140_ChIP-Seq_LNCAP_Human1.19740426
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14866350
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13290240
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12900674
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12684635
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.11302725
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11125918
80* P68_20966046_ChIP-Seq_HELA_Human1.09803352
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09459519
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09019887
83* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08282155
84* MYC_18940864_ChIP-ChIP_HL60_Human1.08004959
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07809188
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07370077
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07176879
88* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07081144
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06142411
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04547057
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01996156
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.01959647
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01790803
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01243144
95* ELF1_20517297_ChIP-Seq_JURKAT_Human1.00898970
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00819637
97MAF_26560356_Chip-Seq_TH1_Human1.00366499
98MAF_26560356_Chip-Seq_TH2_Human1.00365183
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99944853
100* UTX_26944678_Chip-Seq_JUKART_Human0.99128289
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98510549
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98267674
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97691429
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97542922
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97379320
106TP63_19390658_ChIP-ChIP_HaCaT_Human0.95274419
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94396628
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94181940
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93972090
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93824943
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92246258
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91353671
113VDR_24763502_ChIP-Seq_THP-1_Human0.90934470
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90742743
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90589676
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90240246
117TFEB_21752829_ChIP-Seq_HELA_Human0.90053642
118RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89830281
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89532359
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89178495
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89082063
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88143025
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87476396
124SCL_19346495_ChIP-Seq_HPC-7_Human0.85575445

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.25449119
2MP0003693_abnormal_embryo_hatching4.18260701
3MP0004957_abnormal_blastocyst_morpholog3.43198464
4MP0004185_abnormal_adipocyte_glucose3.24072901
5MP0003077_abnormal_cell_cycle2.85685315
6MP0003111_abnormal_nucleus_morphology2.78324710
7MP0010094_abnormal_chromosome_stability2.77770736
8MP0002396_abnormal_hematopoietic_system2.41776346
9MP0002249_abnormal_larynx_morphology2.28644171
10MP0008007_abnormal_cellular_replicative2.23891176
11MP0003763_abnormal_thymus_physiology2.19463921
12MP0008057_abnormal_DNA_replication2.13313090
13MP0000490_abnormal_crypts_of2.13143223
14MP0009333_abnormal_splenocyte_physiolog2.07898720
15MP0008932_abnormal_embryonic_tissue2.06706078
16MP0008058_abnormal_DNA_repair1.99406626
17MP0005451_abnormal_body_composition1.93821400
18MP0003806_abnormal_nucleotide_metabolis1.87137238
19MP0000678_abnormal_parathyroid_gland1.83556925
20MP0003786_premature_aging1.72264090
21MP0005174_abnormal_tail_pigmentation1.68082636
22MP0004808_abnormal_hematopoietic_stem1.66861454
23MP0002163_abnormal_gland_morphology1.64940926
24MP0000685_abnormal_immune_system1.64087423
25MP0000566_synostosis1.58137423
26MP0005666_abnormal_adipose_tissue1.57275700
27MP0003123_paternal_imprinting1.56410762
28MP0002398_abnormal_bone_marrow1.55732646
29MP0001835_abnormal_antigen_presentation1.54823566
30MP0004381_abnormal_hair_follicle1.54410625
31MP0001346_abnormal_lacrimal_gland1.53266007
32MP0002132_abnormal_respiratory_system1.50094671
33MP0000703_abnormal_thymus_morphology1.49931195
34MP0000350_abnormal_cell_proliferation1.47857893
35MP0006036_abnormal_mitochondrial_physio1.45751939
36MP0001800_abnormal_humoral_immune1.44787265
37MP0002722_abnormal_immune_system1.44342521
38MP0009053_abnormal_anal_canal1.41848022
39MP0001730_embryonic_growth_arrest1.38376820
40MP0003941_abnormal_skin_development1.38332670
41MP0002877_abnormal_melanocyte_morpholog1.34118333
42MP0003436_decreased_susceptibility_to1.34039817
43MP0000689_abnormal_spleen_morphology1.31256035
44MP0005671_abnormal_response_to1.31000194
45MP0002019_abnormal_tumor_incidence1.30920877
46MP0002095_abnormal_skin_pigmentation1.29745963
47MP0005397_hematopoietic_system_phenotyp1.28258066
48MP0001545_abnormal_hematopoietic_system1.28258066
49MP0010352_gastrointestinal_tract_polyps1.27688122
50MP0002420_abnormal_adaptive_immunity1.26732976
51MP0002429_abnormal_blood_cell1.26044180
52MP0001819_abnormal_immune_cell1.24396795
53MP0000716_abnormal_immune_system1.24004451
54MP0000537_abnormal_urethra_morphology1.23452941
55MP0009785_altered_susceptibility_to1.23445467
56MP0000313_abnormal_cell_death1.23255374
57MP0002452_abnormal_antigen_presenting1.23207058
58MP0000858_altered_metastatic_potential1.23000782
59MP0005075_abnormal_melanosome_morpholog1.20211588
60MP0002405_respiratory_system_inflammati1.19557146
61MP0000465_gastrointestinal_hemorrhage1.17771726
62MP0003315_abnormal_perineum_morphology1.17132036
63MP0002723_abnormal_immune_serum1.16832334
64MP0005025_abnormal_response_to1.16785319
65MP0002166_altered_tumor_susceptibility1.16188409
66MP0006035_abnormal_mitochondrial_morpho1.16183808
67MP0003136_yellow_coat_color1.15074504
68MP0005000_abnormal_immune_tolerance1.14615599
69MP0001853_heart_inflammation1.14332657
70MP0010155_abnormal_intestine_physiology1.13695404
71MP0010030_abnormal_orbit_morphology1.13396996
72MP0001873_stomach_inflammation1.13173110
73MP0003567_abnormal_fetal_cardiomyocyte1.12488579
74MP0005501_abnormal_skin_physiology1.12371302
75MP0001727_abnormal_embryo_implantation1.10993230
76MP0002210_abnormal_sex_determination1.08444000
77MP0002006_tumorigenesis1.08164460
78MP0006054_spinal_hemorrhage1.07918596
79MP0002277_abnormal_respiratory_mucosa1.07732618
80MP0002080_prenatal_lethality1.05961253
81MP0002148_abnormal_hypersensitivity_rea1.04446061
82MP0001697_abnormal_embryo_size1.03183596
83MP0003938_abnormal_ear_development1.02245929
84MP0002697_abnormal_eye_size1.02219338
85MP0003866_abnormal_defecation1.01022065
86MP0003878_abnormal_ear_physiology1.00778712
87MP0005377_hearing/vestibular/ear_phenot1.00778712
88MP0006292_abnormal_olfactory_placode0.98879118
89MP0000750_abnormal_muscle_regeneration0.98037377
90MP0003942_abnormal_urinary_system0.96983566
91MP0002796_impaired_skin_barrier0.95668662
92MP0005380_embryogenesis_phenotype0.95247288
93MP0001672_abnormal_embryogenesis/_devel0.95247288
94MP0005360_urolithiasis0.93025268
95MP0000681_abnormal_thyroid_gland0.92992091
96MP0005387_immune_system_phenotype0.92815677
97MP0001790_abnormal_immune_system0.92815677
98MP0002938_white_spotting0.91167674
99MP0009672_abnormal_birth_weight0.90944694
100MP0002085_abnormal_embryonic_tissue0.90779377
101MP0003724_increased_susceptibility_to0.89795473
102MP0005076_abnormal_cell_differentiation0.87776359
103MP0001881_abnormal_mammary_gland0.86297298
104MP0004858_abnormal_nervous_system0.85171473
105MP0002088_abnormal_embryonic_growth/wei0.84827056
106MP0003984_embryonic_growth_retardation0.84451227
107MP0002932_abnormal_joint_morphology0.83181572
108MP0001145_abnormal_male_reproductive0.82446505
109MP0004133_heterotaxia0.81673944
110MP0009250_abnormal_appendicular_skeleto0.81137534
111MP0000372_irregular_coat_pigmentation0.80816232
112MP0003186_abnormal_redox_activity0.80218761
113MP0005023_abnormal_wound_healing0.79376563
114MP0002086_abnormal_extraembryonic_tissu0.78456748
115MP0000762_abnormal_tongue_morphology0.78036369
116MP0003453_abnormal_keratinocyte_physiol0.77393694
117MP0002098_abnormal_vibrissa_morphology0.77256287
118MP0002653_abnormal_ependyma_morphology0.77106376
119MP0003718_maternal_effect0.76840037
120MP0008995_early_reproductive_senescence0.76724956
121MP0000477_abnormal_intestine_morphology0.76639890
122MP0002084_abnormal_developmental_patter0.76438442
123MP0000049_abnormal_middle_ear0.75912430
124MP0005375_adipose_tissue_phenotype0.75740496
125MP0001348_abnormal_lacrimal_gland0.74963345
126MP0001216_abnormal_epidermal_layer0.74595123
127MP0000358_abnormal_cell_content/0.74205600
128MP0000733_abnormal_muscle_development0.73934244
129MP0003303_peritoneal_inflammation0.72951670
130MP0009278_abnormal_bone_marrow0.71380490
131MP0001286_abnormal_eye_development0.70343499
132MP0001293_anophthalmia0.69596322
133MP0004197_abnormal_fetal_growth/weight/0.68751289
134MP0005670_abnormal_white_adipose0.67809185
135MP0002111_abnormal_tail_morphology0.66697455
136MP0008789_abnormal_olfactory_epithelium0.66635702
137MP0001845_abnormal_inflammatory_respons0.66146735
138MP0004947_skin_inflammation0.65872618
139MP0005464_abnormal_platelet_physiology0.65510558
140MP0002160_abnormal_reproductive_system0.64972237
141MP0003959_abnormal_lean_body0.64326668
142MP0000613_abnormal_salivary_gland0.63619070
143MP0009931_abnormal_skin_appearance0.63276328
144MP0002092_abnormal_eye_morphology0.63230844
145MP0003119_abnormal_digestive_system0.63210162
146MP0005058_abnormal_lysosome_morphology0.62093501
147MP0000467_abnormal_esophagus_morphology0.59205288

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.86686131
2Reticulocytopenia (HP:0001896)8.31165013
3Abnormal number of erythroid precursors (HP:0012131)8.10602608
4Macrocytic anemia (HP:0001972)6.50291477
5Pallor (HP:0000980)5.92803670
6Aplasia/Hypoplasia of the sacrum (HP:0008517)4.00942271
7Abnormal hemoglobin (HP:0011902)3.99983714
8Acute encephalopathy (HP:0006846)3.63419293
9Thrombocytosis (HP:0001894)3.56597403
10Increased muscle lipid content (HP:0009058)3.46521519
11Progressive muscle weakness (HP:0003323)3.37083658
12Colon cancer (HP:0003003)3.27274123
13Aplastic anemia (HP:0001915)3.22848436
14Multiple enchondromatosis (HP:0005701)3.16226388
15Progressive macrocephaly (HP:0004481)3.05304109
16Trismus (HP:0000211)2.95316214
1711 pairs of ribs (HP:0000878)2.94970192
18Microvesicular hepatic steatosis (HP:0001414)2.88471382
19Abnormality of reticulocytes (HP:0004312)2.86491838
20Congenital, generalized hypertrichosis (HP:0004540)2.82129111
21Oral leukoplakia (HP:0002745)2.80358822
22Exercise intolerance (HP:0003546)2.79527127
23Cerebral edema (HP:0002181)2.79167047
24Depressed nasal ridge (HP:0000457)2.75674289
25Absent thumb (HP:0009777)2.74970147
26IgM deficiency (HP:0002850)2.73868046
27Broad distal phalanx of finger (HP:0009836)2.60188618
28Ragged-red muscle fibers (HP:0003200)2.54934402
29Neonatal hypoglycemia (HP:0001998)2.54436573
30Selective tooth agenesis (HP:0001592)2.53520951
31Increased hepatocellular lipid droplets (HP:0006565)2.48441491
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46853876
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46853876
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45489563
35Lactic acidosis (HP:0003128)2.43446773
36Exertional dyspnea (HP:0002875)2.42424001
37Rough bone trabeculation (HP:0100670)2.40421319
38Elevated erythrocyte sedimentation rate (HP:0003565)2.38204325
39Migraine (HP:0002076)2.36167808
40Breast hypoplasia (HP:0003187)2.36140502
41Thick lower lip vermilion (HP:0000179)2.35254036
42Abnormality of glycolysis (HP:0004366)2.33794069
43Microretrognathia (HP:0000308)2.32345197
44Triphalangeal thumb (HP:0001199)2.31607373
45Cleft eyelid (HP:0000625)2.27060733
46Hepatocellular necrosis (HP:0001404)2.26854836
47Birth length less than 3rd percentile (HP:0003561)2.24804407
48Asplenia (HP:0001746)2.22487897
49Testicular atrophy (HP:0000029)2.21475535
50Mitochondrial inheritance (HP:0001427)2.17152891
51Chronic otitis media (HP:0000389)2.17010601
52Woolly hair (HP:0002224)2.16079986
53Hyperthyroidism (HP:0000836)2.15348170
54Respiratory failure (HP:0002878)2.13507640
55Glossoptosis (HP:0000162)2.12690830
56Increased serum pyruvate (HP:0003542)2.12414803
57Basal cell carcinoma (HP:0002671)2.09614285
58Carpal bone hypoplasia (HP:0001498)2.09226324
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08757283
60Lipid accumulation in hepatocytes (HP:0006561)2.08329403
61Sparse eyelashes (HP:0000653)2.07635812
62Petechiae (HP:0000967)2.05910119
63Abnormal number of incisors (HP:0011064)2.04419911
64Missing ribs (HP:0000921)2.03661019
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.02090585
66Hypoplasia of the radius (HP:0002984)1.99119888
67Stenosis of the external auditory canal (HP:0000402)1.98788243
68Nasolacrimal duct obstruction (HP:0000579)1.97820789
69Respiratory difficulties (HP:0002880)1.97372778
70Type I transferrin isoform profile (HP:0003642)1.95152037
71Abnormality of the parietal bone (HP:0002696)1.94767764
72Hypertensive crisis (HP:0100735)1.94360497
73Patellar aplasia (HP:0006443)1.91132066
74Pancytopenia (HP:0001876)1.90682415
75Concave nail (HP:0001598)1.90631080
76Premature graying of hair (HP:0002216)1.89993406
77Acute necrotizing encephalopathy (HP:0006965)1.89027298
78Myelodysplasia (HP:0002863)1.88850384
79Atresia of the external auditory canal (HP:0000413)1.88584404
80Duplication of thumb phalanx (HP:0009942)1.88539373
81Lymphoma (HP:0002665)1.87639910
82Aplasia/Hypoplasia of the thymus (HP:0010515)1.87603656
83Abnormality of renal resorption (HP:0011038)1.87124523
84Large for gestational age (HP:0001520)1.85516394
85Aplasia/Hypoplasia of the patella (HP:0006498)1.83789142
86Hepatic necrosis (HP:0002605)1.83102027
87Neoplasm of the pancreas (HP:0002894)1.81792594
88Leukodystrophy (HP:0002415)1.81048012
89Increased CSF lactate (HP:0002490)1.80844205
90Recurrent bronchitis (HP:0002837)1.80633093
913-Methylglutaconic aciduria (HP:0003535)1.80576145
92Abnormality of T cell physiology (HP:0011840)1.79512192
93Panhypogammaglobulinemia (HP:0003139)1.77576993
94Partial duplication of thumb phalanx (HP:0009944)1.77419473
95Abnormality of T cells (HP:0002843)1.76721987
96Partial duplication of the phalanx of hand (HP:0009999)1.76654763
97Abnormality of the preputium (HP:0100587)1.76488985
98Increased intramyocellular lipid droplets (HP:0012240)1.75665578
99Hypoplastic left heart (HP:0004383)1.74885596
100Horseshoe kidney (HP:0000085)1.74081609
101Increased serum lactate (HP:0002151)1.72947666
102Abnormality of abdominal situs (HP:0011620)1.72000579
103Abdominal situs inversus (HP:0003363)1.72000579
104Myopathic facies (HP:0002058)1.71793711
105Muscle fiber atrophy (HP:0100295)1.71164112
106Squamous cell carcinoma (HP:0002860)1.69381351
107Poikiloderma (HP:0001029)1.66946789
108Abnormal mitochondria in muscle tissue (HP:0008316)1.66889818
109Tracheoesophageal fistula (HP:0002575)1.66511169
110Abnormal trabecular bone morphology (HP:0100671)1.66455905
111Sparse lateral eyebrow (HP:0005338)1.66219884
112Truncus arteriosus (HP:0001660)1.65820814
113Renal Fanconi syndrome (HP:0001994)1.65339776
114Cellular immunodeficiency (HP:0005374)1.64865324
115Gout (HP:0001997)1.62398587
116Premature ovarian failure (HP:0008209)1.62095672
117Prolonged bleeding time (HP:0003010)1.61038124
118Fragile nails (HP:0001808)1.60571268
119Nasal polyposis (HP:0100582)1.59056779
120Optic nerve coloboma (HP:0000588)1.56426834
121Pustule (HP:0200039)1.56202164
122Mesangial abnormality (HP:0001966)1.55692053
123Cortical visual impairment (HP:0100704)1.55342501
124IgG deficiency (HP:0004315)1.54917053
125Lethargy (HP:0001254)1.54691772
126Hyperphosphaturia (HP:0003109)1.54691663
127Secondary amenorrhea (HP:0000869)1.54501501
128Abnormality of the anterior horn cell (HP:0006802)1.54394796
129Degeneration of anterior horn cells (HP:0002398)1.54394796
130Seborrheic dermatitis (HP:0001051)1.53961320
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.52410898
132Gastrointestinal stroma tumor (HP:0100723)1.52367618
133Emotional lability (HP:0000712)1.51664656
134Achilles tendon contracture (HP:0001771)1.51214068
135Deep palmar crease (HP:0006191)1.49134107
136Abnormal urine phosphate concentration (HP:0012599)1.48706881
137Optic disc pallor (HP:0000543)1.47775923
138Premature skin wrinkling (HP:0100678)1.47560715
139Facial cleft (HP:0002006)1.45810099
140Abnormality of small intestinal villus morphology (HP:0011472)1.45502103
141Villous atrophy (HP:0011473)1.45502103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.74432340
2NME25.22558571
3VRK24.95102980
4BUB13.36085553
5WEE13.34534799
6SMG13.21283208
7TLK12.92927736
8MAP4K12.92803617
9EIF2AK12.69955238
10PIM22.38254585
11EEF2K2.38166890
12STK162.35192015
13RPS6KB22.28091999
14LRRK22.21264328
15VRK12.12355790
16TGFBR11.95255107
17CDC71.92280144
18SRPK11.84922536
19NEK21.83738490
20DYRK31.83458410
21PRPF4B1.77612158
22ERN11.57691084
23TESK21.57626308
24ARAF1.55552827
25CDK71.55041867
26STK101.54333758
27TAF11.50758303
28MKNK11.50095214
29SIK11.49685766
30MAP3K101.48694654
31MST41.44719658
32TAOK21.43761858
33CDK191.40518171
34MAP3K111.39551469
35BLK1.38567261
36RPS6KA41.36132521
37EIF2AK31.35577575
38PASK1.33957408
39AURKB1.26704171
40KDR1.26043738
41BTK1.25785708
42CDK91.24198994
43PIM11.19700331
44TEC1.16084121
45ZAP701.13582925
46ICK1.11124446
47MAP3K81.10080247
48BRSK21.07956108
49CDK81.07061207
50GRK61.06797046
51BRAF1.05640945
52PLK11.05536042
53ILK1.04064918
54TSSK61.04037132
55ACVR1B1.03199086
56TESK11.00860939
57FLT31.00117737
58NME10.99526816
59CDK40.98991896
60NLK0.98395474
61CLK10.96072236
62BCKDK0.91610071
63MAP2K30.91587621
64AURKA0.88739805
65IKBKB0.87481739
66IRAK20.85903524
67KIT0.84751222
68PLK40.84312010
69MAPKAPK30.83815881
70MKNK20.83419283
71CDK120.82973385
72PAK40.82869794
73ATR0.79460553
74TTK0.76658089
75PKN20.71577367
76EPHA20.69680890
77CSNK2A20.69396736
78TYK20.69274078
79EPHB20.66593496
80PAK10.66291811
81MAP3K30.65566120
82CSF1R0.64448138
83PBK0.64248496
84SYK0.63413722
85TXK0.63177681
86NEK10.62799964
87CSNK2A10.62304344
88RPS6KA50.61328789
89EIF2AK20.60858803
90IRAK40.60586439
91JAK30.60224629
92SCYL20.58820077
93TBK10.58434070
94STK40.57748273
95IRAK30.55279836
96LCK0.54454893
97CHEK20.54406030
98LYN0.52128897
99CHEK10.51745604
100DYRK20.51078016
101IKBKE0.50880176
102PRKCI0.49174573
103CDK60.46767569
104ABL20.45911413
105ITK0.45408752
106AKT20.43903217
107MAP2K20.43486857
108PDPK10.43184428
109DAPK30.42094883
110PAK20.41965464
111PRKD30.41549470
112BRSK10.40500904
113TGFBR20.39129641
114RPS6KA60.38040376
115PRKD20.37974318
116MAPK150.37972067
117RPS6KL10.37860000
118RPS6KC10.37860000
119CDK11A0.36502504
120DYRK1B0.36312259
121MAPK40.35457813
122CDK20.34904084
123MELK0.34277117
124HIPK20.33970126
125SIK20.33388406
126PTK60.33320010
127MAPKAPK20.33294548
128RPS6KA10.32448455
129CHUK0.31670349
130MTOR0.31538191
131CDK10.30332655
132LIMK10.28219537
133MAPK110.28093179
134IRAK10.26343056
135MAP3K130.25653884
136MARK30.24060307
137BMX0.23393841
138DMPK0.22653949
139TAOK10.20582135

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.87078351
2DNA replication_Homo sapiens_hsa030304.04569077
3RNA polymerase_Homo sapiens_hsa030203.30611456
4Mismatch repair_Homo sapiens_hsa034303.20944628
5Spliceosome_Homo sapiens_hsa030403.12417790
6Proteasome_Homo sapiens_hsa030502.96248218
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57958852
8Homologous recombination_Homo sapiens_hsa034402.47496440
9Base excision repair_Homo sapiens_hsa034102.43423764
10Pyrimidine metabolism_Homo sapiens_hsa002402.38796084
11Nucleotide excision repair_Homo sapiens_hsa034202.26155838
12RNA transport_Homo sapiens_hsa030132.12463853
13One carbon pool by folate_Homo sapiens_hsa006701.85027930
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67036657
15Cell cycle_Homo sapiens_hsa041101.64273798
16Protein export_Homo sapiens_hsa030601.54314494
17Parkinsons disease_Homo sapiens_hsa050121.50447884
18Fanconi anemia pathway_Homo sapiens_hsa034601.49375195
19Primary immunodeficiency_Homo sapiens_hsa053401.47151052
20Cardiac muscle contraction_Homo sapiens_hsa042601.46003649
21Oxidative phosphorylation_Homo sapiens_hsa001901.45905223
22RNA degradation_Homo sapiens_hsa030181.40387060
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37553947
24Non-homologous end-joining_Homo sapiens_hsa034501.36508254
25Sulfur relay system_Homo sapiens_hsa041221.34805104
26Basal transcription factors_Homo sapiens_hsa030221.32047406
27p53 signaling pathway_Homo sapiens_hsa041151.30663809
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.22953787
29Huntingtons disease_Homo sapiens_hsa050161.21190940
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15066428
31Purine metabolism_Homo sapiens_hsa002301.09645241
32Epstein-Barr virus infection_Homo sapiens_hsa051691.08544626
33Antigen processing and presentation_Homo sapiens_hsa046121.05778104
34mRNA surveillance pathway_Homo sapiens_hsa030151.05426647
35Herpes simplex infection_Homo sapiens_hsa051681.02499483
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01130499
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98032100
38Carbon metabolism_Homo sapiens_hsa012000.95309960
39Systemic lupus erythematosus_Homo sapiens_hsa053220.88043953
40Pentose phosphate pathway_Homo sapiens_hsa000300.86017035
41Alzheimers disease_Homo sapiens_hsa050100.85576132
42Folate biosynthesis_Homo sapiens_hsa007900.75297525
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74502065
44Hematopoietic cell lineage_Homo sapiens_hsa046400.72871681
45Thyroid cancer_Homo sapiens_hsa052160.71865945
46Fructose and mannose metabolism_Homo sapiens_hsa000510.70631229
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70609787
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69295561
49Pyruvate metabolism_Homo sapiens_hsa006200.68840313
50Measles_Homo sapiens_hsa051620.67497822
51HTLV-I infection_Homo sapiens_hsa051660.67309593
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.65944289
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.63412059
54Galactose metabolism_Homo sapiens_hsa000520.63144175
55Viral carcinogenesis_Homo sapiens_hsa052030.60096738
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.59166200
57Acute myeloid leukemia_Homo sapiens_hsa052210.58948859
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57543353
59Shigellosis_Homo sapiens_hsa051310.56611713
60Non-small cell lung cancer_Homo sapiens_hsa052230.55725946
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55530127
62Glutathione metabolism_Homo sapiens_hsa004800.53446849
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52845563
64Pancreatic cancer_Homo sapiens_hsa052120.51987820
65Apoptosis_Homo sapiens_hsa042100.51453167
66Small cell lung cancer_Homo sapiens_hsa052220.50359432
67Fatty acid elongation_Homo sapiens_hsa000620.48714254
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48346453
69Leishmaniasis_Homo sapiens_hsa051400.48205056
70Legionellosis_Homo sapiens_hsa051340.47773832
71B cell receptor signaling pathway_Homo sapiens_hsa046620.46085878
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45185887
73Bladder cancer_Homo sapiens_hsa052190.43907867
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43019954
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42446544
76Hepatitis B_Homo sapiens_hsa051610.41546425
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.41235327
78Basal cell carcinoma_Homo sapiens_hsa052170.41149658
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40082713
80T cell receptor signaling pathway_Homo sapiens_hsa046600.40054302
81N-Glycan biosynthesis_Homo sapiens_hsa005100.39659703
82Notch signaling pathway_Homo sapiens_hsa043300.39181511
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.38366354
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38191341
85Allograft rejection_Homo sapiens_hsa053300.37634821
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37572560
87Arachidonic acid metabolism_Homo sapiens_hsa005900.34309824
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32591253
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32532797
90Chronic myeloid leukemia_Homo sapiens_hsa052200.32314692
91Renal cell carcinoma_Homo sapiens_hsa052110.32146600
92Asthma_Homo sapiens_hsa053100.32040460
93Other glycan degradation_Homo sapiens_hsa005110.31923094
94MicroRNAs in cancer_Homo sapiens_hsa052060.29594200
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.29165935
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28457257
97Influenza A_Homo sapiens_hsa051640.28131667
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27930931
99Pathways in cancer_Homo sapiens_hsa052000.27046974
100Viral myocarditis_Homo sapiens_hsa054160.26876587
101VEGF signaling pathway_Homo sapiens_hsa043700.26601906
102Colorectal cancer_Homo sapiens_hsa052100.24961683
103Graft-versus-host disease_Homo sapiens_hsa053320.23864892
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23368048
105Phenylalanine metabolism_Homo sapiens_hsa003600.23018233
106Biosynthesis of amino acids_Homo sapiens_hsa012300.22097466
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.22057395
108Toxoplasmosis_Homo sapiens_hsa051450.22055167
109HIF-1 signaling pathway_Homo sapiens_hsa040660.21844679
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21766089
111Metabolic pathways_Homo sapiens_hsa011000.21701172
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21151276
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20889337
114TGF-beta signaling pathway_Homo sapiens_hsa043500.20355468
115Tyrosine metabolism_Homo sapiens_hsa003500.20306490
116Alcoholism_Homo sapiens_hsa050340.19854296
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19702964
118Prostate cancer_Homo sapiens_hsa052150.18776117
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18371385
120Oocyte meiosis_Homo sapiens_hsa041140.17501104
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17403495
122Melanoma_Homo sapiens_hsa052180.17070148
123Prion diseases_Homo sapiens_hsa050200.16896595
124Pertussis_Homo sapiens_hsa051330.16861447
125Endometrial cancer_Homo sapiens_hsa052130.14725981
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12756386
127Arginine and proline metabolism_Homo sapiens_hsa003300.10579659
128Hedgehog signaling pathway_Homo sapiens_hsa043400.08682413
129Wnt signaling pathway_Homo sapiens_hsa043100.08206274
130Selenocompound metabolism_Homo sapiens_hsa004500.06017403
131mTOR signaling pathway_Homo sapiens_hsa041500.04871493

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