RPS12P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil migration (GO:0072677)9.94477262
2cellular response to ethanol (GO:0071361)7.34552101
3immunoglobulin mediated immune response (GO:0016064)5.31685488
4neutrophil activation involved in immune response (GO:0002283)5.30650379
5regulation of mononuclear cell migration (GO:0071675)5.27817881
6regulation of macrophage chemotaxis (GO:0010758)4.90536464
7T cell migration (GO:0072678)4.85790864
8positive regulation of cAMP-mediated signaling (GO:0043950)4.79307385
9cellular extravasation (GO:0045123)4.70948295
10regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.56764502
11positive regulation of mast cell activation (GO:0033005)4.55526586
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49217038
13response to peptidoglycan (GO:0032494)4.34469039
14positive regulation of type 2 immune response (GO:0002830)4.32967420
15negative regulation of interleukin-12 production (GO:0032695)4.32747085
16modulation by symbiont of host immune response (GO:0052553)4.31329279
17positive regulation by symbiont of host defense response (GO:0052509)4.31329279
18modulation by symbiont of host defense response (GO:0052031)4.31329279
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31329279
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31329279
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.31329279
22detection of molecule of bacterial origin (GO:0032490)4.31188234
23macrophage activation involved in immune response (GO:0002281)4.24053182
24phagocytosis, recognition (GO:0006910)4.13059811
25B cell mediated immunity (GO:0019724)4.11188659
26positive regulation of mast cell activation involved in immune response (GO:0033008)4.04427223
27positive regulation of mast cell degranulation (GO:0043306)4.04427223
28microglial cell activation (GO:0001774)4.02744484
29lymphocyte chemotaxis (GO:0048247)3.93047714
30positive regulation of gamma-delta T cell activation (GO:0046645)3.87566150
31granulocyte chemotaxis (GO:0071621)3.84980220
32regulation of lymphocyte chemotaxis (GO:1901623)3.81638336
33interferon-gamma-mediated signaling pathway (GO:0060333)3.79352330
34positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.73588975
35positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.73206170
36granulocyte migration (GO:0097530)3.69675290
37regulation of T cell tolerance induction (GO:0002664)3.69268813
38regulation of hypersensitivity (GO:0002883)3.64883446
39detection of other organism (GO:0098543)3.64133424
40antigen processing and presentation of endogenous antigen (GO:0019883)3.63540871
41detection of external biotic stimulus (GO:0098581)3.60349982
42monocyte chemotaxis (GO:0002548)3.57843162
43regulation of tolerance induction (GO:0002643)3.55698082
44positive regulation of lymphocyte migration (GO:2000403)3.52160389
45regulation of mast cell activation (GO:0033003)3.50999198
46defense response to protozoan (GO:0042832)3.49948936
47antigen processing and presentation via MHC class Ib (GO:0002475)3.49018384
48regulation of mast cell degranulation (GO:0043304)3.43858912
49response to host immune response (GO:0052572)3.42986274
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42986274
51phagocytosis, engulfment (GO:0006911)3.42535336
52macrophage activation (GO:0042116)3.39238077
53platelet dense granule organization (GO:0060155)3.39181796
54regulation of mast cell activation involved in immune response (GO:0033006)3.36460706
55detection of bacterium (GO:0016045)3.34971020
56positive regulation of toll-like receptor signaling pathway (GO:0034123)3.34920115
57neutrophil activation (GO:0042119)3.34855288
58myeloid cell activation involved in immune response (GO:0002275)3.32727029
59regulation of T-helper 2 cell differentiation (GO:0045628)3.29584436
60regulation of lymphocyte migration (GO:2000401)3.23728102
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20719415
62type I interferon signaling pathway (GO:0060337)3.18911926
63cellular response to type I interferon (GO:0071357)3.18911926
64response to type I interferon (GO:0034340)3.16497176
65detection of biotic stimulus (GO:0009595)3.13726080
66cell wall macromolecule catabolic process (GO:0016998)3.12021578
67positive regulation of macrophage cytokine production (GO:0060907)3.10435602
68regulation of interferon-beta biosynthetic process (GO:0045357)3.08502700
69lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07107093
70positive regulation of interferon-beta production (GO:0032728)3.06882599
71negative regulation of cell killing (GO:0031342)3.04438298
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04438298
73regulation of B cell receptor signaling pathway (GO:0050855)3.02038291
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01529484
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00929370
76positive regulation of interferon-alpha production (GO:0032727)2.99071445
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.97741954
78positive thymic T cell selection (GO:0045059)2.96861105
79cellular response to interferon-gamma (GO:0071346)2.96508118
80myeloid leukocyte mediated immunity (GO:0002444)2.94998546
81granulocyte activation (GO:0036230)2.94976725
82response to protozoan (GO:0001562)2.93586821
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92497944
84response to host (GO:0075136)2.92497944
85response to host defenses (GO:0052200)2.92497944
86adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.91879436
87T-helper 1 type immune response (GO:0042088)2.91655049
88regulation of interferon-alpha production (GO:0032647)2.90358366
89mast cell activation (GO:0045576)2.88658752
90response to interferon-gamma (GO:0034341)2.85561889
91membrane invagination (GO:0010324)2.85276810
92T cell proliferation (GO:0042098)2.84498492
93positive regulation of immunoglobulin mediated immune response (GO:0002891)2.81818009
94positive regulation of B cell mediated immunity (GO:0002714)2.81818009
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81728696
96regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.81434907
97regulation of macrophage cytokine production (GO:0010935)2.79352114
98regulation of gamma-delta T cell activation (GO:0046643)2.78497421
99regulation of inflammatory response to antigenic stimulus (GO:0002861)2.76876430
100eosinophil chemotaxis (GO:0048245)11.0575960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.28650606
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.67295352
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.63754148
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39375164
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.29471446
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23826396
7GATA1_22025678_ChIP-Seq_K562_Human3.07766981
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.97749716
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84631281
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72632992
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.69613081
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60851302
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48392713
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.46736041
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42339096
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33690755
17VDR_24787735_ChIP-Seq_THP-1_Human2.29268835
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18221151
19PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.17498608
20RUNX_20019798_ChIP-Seq_JUKART_Human2.09475315
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96570252
22SPI1_23547873_ChIP-Seq_NB4_Human1.93735831
23SPI1_23127762_ChIP-Seq_K562_Human1.88020672
24SCL_19346495_ChIP-Seq_HPC-7_Human1.87441353
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79180831
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76666420
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76455212
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75459477
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.75230196
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67039320
31MYB_26560356_Chip-Seq_TH2_Human1.66591532
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55556405
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55029141
34TFEB_21752829_ChIP-Seq_HELA_Human1.50523888
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46366687
36VDR_24763502_ChIP-Seq_THP-1_Human1.39049913
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36503326
38GATA3_27048872_Chip-Seq_THYMUS_Human1.35535840
39GATA3_26560356_Chip-Seq_TH2_Human1.33780803
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33154971
41TP53_16413492_ChIP-PET_HCT116_Human1.30147414
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28008418
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.27502681
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27102424
45ER_23166858_ChIP-Seq_MCF-7_Human1.24655546
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23435819
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23381182
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23069682
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23010204
50PU_27001747_Chip-Seq_BMDM_Mouse1.20038261
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19847774
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.18530602
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17838688
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17838688
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17059011
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14177210
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14047669
58MYB_26560356_Chip-Seq_TH1_Human1.11760019
59SMRT_27268052_Chip-Seq_Bcells_Human1.11379377
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09712095
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09664006
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08760212
63GBX2_23144817_ChIP-Seq_PC3_Human1.07590806
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.03921109
65CDX2_22108803_ChIP-Seq_LS180_Human1.03559106
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03464476
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01816598
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01625167
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01113392
70SALL4_22934838_ChIP-ChIP_CD34+_Human0.95595198
71STAT1_20625510_ChIP-Seq_HELA_Human0.95396734
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95383386
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93775374
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93209591
75PRDM14_20953172_ChIP-Seq_ESCs_Human0.93043826
76TAF15_26573619_Chip-Seq_HEK293_Human0.92875788
77ZNF274_21170338_ChIP-Seq_K562_Hela0.92856562
78P300_19829295_ChIP-Seq_ESCs_Human0.92172282
79AR_25329375_ChIP-Seq_VCAP_Human0.91965464
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90804718
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90795385
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.89566627
83CMYC_18555785_Chip-Seq_ESCs_Mouse0.89189468
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88700796
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88017488
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87957051
87CBP_20019798_ChIP-Seq_JUKART_Human0.87957051
88EGR1_19374776_ChIP-ChIP_THP-1_Human0.87914744
89GATA2_19941826_ChIP-Seq_K562_Human0.86030165
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85709494
91STAT3_23295773_ChIP-Seq_U87_Human0.84264511
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84131734
93SMAD4_21799915_ChIP-Seq_A2780_Human0.83784852
94BCAT_22108803_ChIP-Seq_LS180_Human0.83482733
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82890307
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82097715
97TCF4_23295773_ChIP-Seq_U87_Human0.82055768
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.81669386
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79005264
100RUNX1_22412390_ChIP-Seq_EML_Mouse0.78547704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.28280522
2MP0000015_abnormal_ear_pigmentation4.47863750
3MP0001835_abnormal_antigen_presentation4.06561191
4MP0005174_abnormal_tail_pigmentation3.73902296
5MP0003172_abnormal_lysosome_physiology3.57937301
6MP0003191_abnormal_cellular_cholesterol3.44790197
7MP0002148_abnormal_hypersensitivity_rea3.08841304
8MP0003724_increased_susceptibility_to2.94621648
9MP0000372_irregular_coat_pigmentation2.92968892
10MP0006082_CNS_inflammation2.88333030
11MP0005171_absent_coat_pigmentation2.77030708
12MP0003806_abnormal_nucleotide_metabolis2.71183524
13MP0009785_altered_susceptibility_to2.67145735
14MP0005671_abnormal_response_to2.56223816
15MP0002095_abnormal_skin_pigmentation2.50705495
16MP0005000_abnormal_immune_tolerance2.47128732
17MP0004381_abnormal_hair_follicle2.44819942
18MP0002419_abnormal_innate_immunity2.42102620
19MP0003436_decreased_susceptibility_to2.25911342
20MP0001800_abnormal_humoral_immune2.22742653
21MP0005025_abnormal_response_to2.22549652
22MP0002452_abnormal_antigen_presenting2.05228126
23MP0005408_hypopigmentation2.04170099
24MP0000371_diluted_coat_color2.01774547
25MP0005075_abnormal_melanosome_morpholog2.01651667
26MP0002723_abnormal_immune_serum2.00177183
27MP0001790_abnormal_immune_system1.97760644
28MP0005387_immune_system_phenotype1.97760644
29MP0003183_abnormal_peptide_metabolism1.95427453
30MP0000685_abnormal_immune_system1.92627538
31MP0005464_abnormal_platelet_physiology1.81939884
32MP0002420_abnormal_adaptive_immunity1.79675906
33MP0001819_abnormal_immune_cell1.78256759
34MP0009840_abnormal_foam_cell1.69458326
35MP0002277_abnormal_respiratory_mucosa1.67943495
36MP0003136_yellow_coat_color1.63193760
37MP0003303_peritoneal_inflammation1.62795121
38MP0008260_abnormal_autophagy1.61178358
39MP0001845_abnormal_inflammatory_respons1.47747417
40MP0000604_amyloidosis1.43467052
41MP0009764_decreased_sensitivity_to1.39774490
42MP0005310_abnormal_salivary_gland1.35234347
43MP0006054_spinal_hemorrhage1.32788924
44MP0000716_abnormal_immune_system1.29951866
45MP0001533_abnormal_skeleton_physiology1.28301036
46MP0003186_abnormal_redox_activity1.27933449
47MP0003828_pulmonary_edema1.25697924
48MP0002877_abnormal_melanocyte_morpholog1.22751685
49MP0008469_abnormal_protein_level1.20674894
50MP0000343_altered_response_to1.17782677
51MP0001324_abnormal_eye_pigmentation1.17649300
52MP0000920_abnormal_myelination1.16248540
53MP0004883_abnormal_blood_vessel1.14849395
54MP0005164_abnormal_response_to1.11252572
55MP0003252_abnormal_bile_duct1.11091278
56MP0002398_abnormal_bone_marrow1.09525205
57MP0005058_abnormal_lysosome_morphology1.06607638
58MP0005409_darkened_coat_color1.06201755
59MP0001186_pigmentation_phenotype1.04439853
60MP0002075_abnormal_coat/hair_pigmentati1.04012086
61MP0000689_abnormal_spleen_morphology0.99064464
62MP0002405_respiratory_system_inflammati0.97702824
63MP0002429_abnormal_blood_cell0.92131869
64MP0005367_renal/urinary_system_phenotyp0.88687457
65MP0000516_abnormal_urinary_system0.88687457
66MP0009333_abnormal_splenocyte_physiolog0.88507373
67MP0004484_altered_response_of0.88130488
68MP0002166_altered_tumor_susceptibility0.86172236
69MP0004947_skin_inflammation0.84900928
70MP0003075_altered_response_to0.83978172
71MP0004742_abnormal_vestibular_system0.83785299
72MP0009763_increased_sensitivity_to0.81549273
73MP0005167_abnormal_blood-brain_barrier0.80077494
74MP0009765_abnormal_xenobiotic_induced0.79442594
75MP0002722_abnormal_immune_system0.77655267
76MP0003656_abnormal_erythrocyte_physiolo0.77162176
77MP0001986_abnormal_taste_sensitivity0.76945664
78MP0002998_abnormal_bone_remodeling0.73270246
79MP0002653_abnormal_ependyma_morphology0.70952659
80MP0004510_myositis0.70259069
81MP0001851_eye_inflammation0.69826446
82MP0002693_abnormal_pancreas_physiology0.68500640
83MP0002332_abnormal_exercise_endurance0.67162004
84MP0003763_abnormal_thymus_physiology0.66670867
85MP0003448_altered_tumor_morphology0.66391194
86MP0001663_abnormal_digestive_system0.65736326
87MP0005365_abnormal_bile_salt0.65599171
88MP0003632_abnormal_nervous_system0.63445978
89MP0005376_homeostasis/metabolism_phenot0.62556063
90MP0005248_abnormal_Harderian_gland0.62150116
91MP0010307_abnormal_tumor_latency0.60497220
92MP0002909_abnormal_adrenal_gland0.59748350
93MP0003690_abnormal_glial_cell0.58784526
94MP0008875_abnormal_xenobiotic_pharmacok0.56624363
95MP0010155_abnormal_intestine_physiology0.55987080
96MP0002177_abnormal_outer_ear0.55447993
97MP0009697_abnormal_copulation0.54898963
98MP0003091_abnormal_cell_migration0.53547436
99MP0005166_decreased_susceptibility_to0.50987574
100MP0002254_reproductive_system_inflammat0.49800335

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.97660829
2Recurrent abscess formation (HP:0002722)5.13919675
3Recurrent skin infections (HP:0001581)4.68051866
4Recurrent cutaneous fungal infections (HP:0011370)4.48764496
5Chronic mucocutaneous candidiasis (HP:0002728)4.48764496
6Albinism (HP:0001022)4.38171415
7Systemic lupus erythematosus (HP:0002725)4.11421352
8Abnormality of macrophages (HP:0004311)3.88918495
9Glomerulonephritis (HP:0000099)3.65546169
10Gingivitis (HP:0000230)3.49890185
11Generalized hypopigmentation (HP:0007513)3.44257290
12Recurrent gram-negative bacterial infections (HP:0005420)3.42765254
13Periodontitis (HP:0000704)3.42350024
14Prostate neoplasm (HP:0100787)3.42016430
15Stomatitis (HP:0010280)3.41854488
16Recurrent fungal infections (HP:0002841)3.36120546
17Pustule (HP:0200039)3.31548743
18Ocular albinism (HP:0001107)3.26525571
19Thick nail (HP:0001805)3.19924703
20Cheilitis (HP:0100825)3.15785552
21Retrobulbar optic neuritis (HP:0100654)3.15776330
22Optic neuritis (HP:0100653)3.15776330
23Gastrointestinal infarctions (HP:0005244)3.15754724
24Abnormality of the prostate (HP:0008775)3.14354612
25Aplasia/Hypoplasia of the macula (HP:0008059)3.13505688
26Hemoptysis (HP:0002105)3.10666998
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.94179151
28Hypoplasia of the fovea (HP:0007750)2.94179151
29Orchitis (HP:0100796)2.90765038
30Aplasia/Hypoplasia affecting the retina (HP:0008061)2.87682211
31Eczematoid dermatitis (HP:0000976)2.84991198
32Esophageal neoplasm (HP:0100751)2.83651602
33Neoplasm of head and neck (HP:0012288)2.83651602
34Abnormality of liposaccharide metabolism (HP:0010968)2.82361499
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.82361499
36Abnormality of glycolipid metabolism (HP:0010969)2.82361499
37Iris hypopigmentation (HP:0007730)2.81747900
38Myositis (HP:0100614)2.72816899
39Pulmonary infiltrates (HP:0002113)2.65137362
40Abnormality of polysaccharide metabolism (HP:0011012)2.62716008
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62716008
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62716008
43Gingival bleeding (HP:0000225)2.60251051
44Premature loss of primary teeth (HP:0006323)2.60110854
45Urticaria (HP:0001025)2.58209127
46Mediastinal lymphadenopathy (HP:0100721)2.57584375
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.54485384
48Mucopolysacchariduria (HP:0008155)2.49802991
49Urinary glycosaminoglycan excretion (HP:0003541)2.49802991
50Spinal muscular atrophy (HP:0007269)2.47835727
51Vasculitis (HP:0002633)2.44949122
52Dysostosis multiplex (HP:0000943)2.42203854
53Amyloidosis (HP:0011034)2.40725906
54Loss of speech (HP:0002371)2.39825918
55Chest pain (HP:0100749)2.34054375
56Epistaxis (HP:0000421)2.31481196
57Spontaneous hematomas (HP:0007420)2.29473917
58Meningitis (HP:0001287)2.29127280
59Prolonged bleeding time (HP:0003010)2.28209627
60Chronic obstructive pulmonary disease (HP:0006510)2.26398687
61Obstructive lung disease (HP:0006536)2.26398687
62Abnormality of T cell number (HP:0011839)2.23651591
63Bilateral sensorineural hearing impairment (HP:0008619)2.23241157
64Abnormal platelet volume (HP:0011876)2.22292812
65Severe visual impairment (HP:0001141)2.19537478
66Congenital sensorineural hearing impairment (HP:0008527)2.17330081
67Abnormality of the fovea (HP:0000493)2.16384248
68T lymphocytopenia (HP:0005403)2.15589384
69Progressive cerebellar ataxia (HP:0002073)2.12170967
70Increased mean platelet volume (HP:0011877)2.11784019
71Abnormality of the left ventricular outflow tract (HP:0011103)2.11491107
72Subaortic stenosis (HP:0001682)2.11491107
73Increased cerebral lipofuscin (HP:0011813)2.06580840
74Type I transferrin isoform profile (HP:0003642)2.06461618
75Reduced antithrombin III activity (HP:0001976)2.05145463
76Osteolytic defects of the hand bones (HP:0009699)2.03921383
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.03921383
78Encephalitis (HP:0002383)2.03592980
79Hypoproteinemia (HP:0003075)2.02528559
80Keratoconjunctivitis sicca (HP:0001097)2.00692371
81Complement deficiency (HP:0004431)1.97420328
82Hip dysplasia (HP:0001385)1.97058342
83Abnormality of the endocardium (HP:0004306)1.96959508
84Postural instability (HP:0002172)1.96613643
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.95799670
86Vacuolated lymphocytes (HP:0001922)1.94456870
87Recurrent viral infections (HP:0004429)1.94118123
88Impaired platelet aggregation (HP:0003540)1.93297475
89Abnormal platelet function (HP:0011869)1.93297475
90Abnormality of the peritoneum (HP:0002585)1.92343702
91Arterial tortuosity (HP:0005116)1.91360929
92Cutaneous melanoma (HP:0012056)1.89940546
93Blue irides (HP:0000635)1.88011925
94Melanoma (HP:0002861)1.87082415
95Abnormality of male internal genitalia (HP:0000022)1.86201283
96Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85882769
97Abnormality of the anterior horn cell (HP:0006802)1.85235763
98Degeneration of anterior horn cells (HP:0002398)1.85235763
99Gangrene (HP:0100758)1.84441177
100Keratoconjunctivitis (HP:0001096)1.83849630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK8.63722254
2WNK33.23734969
3TYK22.96358946
4RIPK42.88624713
5PIK3CG2.63521176
6CSK2.62465431
7BMPR22.62410610
8PDK22.48906874
9FRK2.14327448
10JAK12.10641233
11TGFBR22.06872873
12SYK2.05103724
13MAP2K31.96891288
14PAK31.80530393
15MARK31.78248697
16MAP3K141.75480414
17TRPM71.63693704
18FES1.54224729
19IRAK41.54121139
20FER1.51853582
21FGR1.51047701
22LYN1.48638790
23KIT1.44125704
24MAP3K31.31872321
25TAOK31.29824203
26YES11.27962946
27TXK1.27959707
28CSF1R1.20306828
29JAK31.16433911
30CAMKK21.12952696
31ACVR1B1.12345805
32SGK21.10345893
33EIF2AK31.07643540
34KSR11.06669280
35STK38L1.06337514
36IKBKE1.05527225
37PTK2B1.03843688
38ZAP701.03288695
39MAP4K11.00977601
40MAPKAPK51.00169141
41CAMK1G0.98046441
42HCK0.97116321
43SGK30.96013435
44PDGFRB0.92568437
45TAF10.91108249
46BTK0.84380615
47CAMK1D0.84164377
48MKNK10.82008662
49IKBKB0.81401823
50MAP3K20.78646678
51LCK0.77279626
52TNK20.75091987
53MATK0.74979338
54EGFR0.72279674
55GRK60.69787177
56ITK0.68845627
57FYN0.66543205
58PRKCH0.65625027
59MAP2K10.64216585
60CAMK40.62198128
61TEC0.61681731
62WNK10.60459605
63ABL10.59902104
64JAK20.58162333
65STK40.53241081
66ERBB20.52205030
67FGFR10.51962395
68TESK20.51961635
69ADRBK20.51171893
70SGK2230.51018006
71SGK4940.51018006
72MAP3K70.50044912
73PLK20.49863152
74RPS6KA50.49743249
75IRAK10.47751448
76EPHB20.47699004
77PRKCQ0.47052076
78MAP3K40.44144410
79PDK10.41668206
80TBK10.39529746
81EIF2AK20.37407428
82STK110.36725732
83PRKAA20.36147232
84CHUK0.35452294
85MAPK120.34905295
86NEK60.34463890
87MAPK110.34105542
88AKT30.33133158
89STK380.28565604
90INSR0.27971115
91STK240.27969620
92PRKCI0.27350446
93ERBB30.26916359
94MAP3K10.26533846
95MAPK130.26497446
96IGF1R0.25469634
97PRKACB0.21995272
98MAP2K60.20683810
99PIM10.20516617
100GSK3A0.18989571

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.12584532
2Asthma_Homo sapiens_hsa053104.45518614
3Allograft rejection_Homo sapiens_hsa053304.11568281
4Autoimmune thyroid disease_Homo sapiens_hsa053203.88618674
5Graft-versus-host disease_Homo sapiens_hsa053323.76118682
6Type I diabetes mellitus_Homo sapiens_hsa049403.46336200
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.34058765
8Leishmaniasis_Homo sapiens_hsa051403.19419477
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51778509
10Rheumatoid arthritis_Homo sapiens_hsa053232.43474764
11Viral myocarditis_Homo sapiens_hsa054162.29822124
12Tuberculosis_Homo sapiens_hsa051522.24793888
13Antigen processing and presentation_Homo sapiens_hsa046122.14218433
14Osteoclast differentiation_Homo sapiens_hsa043802.01895802
15Phagosome_Homo sapiens_hsa041452.01173246
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94947024
17Hematopoietic cell lineage_Homo sapiens_hsa046401.78385270
18Chemokine signaling pathway_Homo sapiens_hsa040621.77949342
19Other glycan degradation_Homo sapiens_hsa005111.74963243
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.68590913
21Influenza A_Homo sapiens_hsa051641.65328059
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55848674
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37051071
24Lysosome_Homo sapiens_hsa041421.35051525
25Toxoplasmosis_Homo sapiens_hsa051451.35010920
26Herpes simplex infection_Homo sapiens_hsa051681.34171334
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33329150
28Measles_Homo sapiens_hsa051621.26313476
29Vitamin B6 metabolism_Homo sapiens_hsa007501.26001819
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.22953096
31Malaria_Homo sapiens_hsa051441.16576195
32Complement and coagulation cascades_Homo sapiens_hsa046101.06686162
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04985602
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02910969
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02903621
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01345453
37B cell receptor signaling pathway_Homo sapiens_hsa046621.01070567
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97438847
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94634534
40Sphingolipid metabolism_Homo sapiens_hsa006000.94104754
41Legionellosis_Homo sapiens_hsa051340.92626822
42Collecting duct acid secretion_Homo sapiens_hsa049660.85337394
43Caffeine metabolism_Homo sapiens_hsa002320.85085821
44Pertussis_Homo sapiens_hsa051330.81258755
45Dorso-ventral axis formation_Homo sapiens_hsa043200.80546420
46African trypanosomiasis_Homo sapiens_hsa051430.79591582
47Systemic lupus erythematosus_Homo sapiens_hsa053220.77775888
48TNF signaling pathway_Homo sapiens_hsa046680.74564188
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73183162
50Primary immunodeficiency_Homo sapiens_hsa053400.70093340
51Platelet activation_Homo sapiens_hsa046110.67281282
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64523365
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59717543
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.59269588
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.57911798
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56596877
57Epstein-Barr virus infection_Homo sapiens_hsa051690.54690190
58Shigellosis_Homo sapiens_hsa051310.51898993
59Ether lipid metabolism_Homo sapiens_hsa005650.47821733
60T cell receptor signaling pathway_Homo sapiens_hsa046600.47739631
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.37765934
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35678534
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.34793318
64Fatty acid elongation_Homo sapiens_hsa000620.33602825
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33357410
66Hepatitis B_Homo sapiens_hsa051610.33150523
67Hepatitis C_Homo sapiens_hsa051600.31670245
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.30592256
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25313721
70Inositol phosphate metabolism_Homo sapiens_hsa005620.23592816
71FoxO signaling pathway_Homo sapiens_hsa040680.19092363
72Salmonella infection_Homo sapiens_hsa051320.17167810
73Non-homologous end-joining_Homo sapiens_hsa034500.17148750
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16087276
75Linoleic acid metabolism_Homo sapiens_hsa005910.15315834
76Apoptosis_Homo sapiens_hsa042100.14489217
77ABC transporters_Homo sapiens_hsa020100.14189502
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13001708
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12956081
80Endocytosis_Homo sapiens_hsa041440.10645918
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10156302
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.08572494
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07816110
84HTLV-I infection_Homo sapiens_hsa051660.06950364
85Protein export_Homo sapiens_hsa030600.06672447
86Lysine degradation_Homo sapiens_hsa003100.05665308
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.04817062
88GnRH signaling pathway_Homo sapiens_hsa049120.04482158
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04215618
90Non-small cell lung cancer_Homo sapiens_hsa052230.03762453
91Regulation of autophagy_Homo sapiens_hsa041400.01614942
92Arachidonic acid metabolism_Homo sapiens_hsa005900.01161987
93beta-Alanine metabolism_Homo sapiens_hsa004100.00534286
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0264080
95Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0242713
96Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0171903
97Insulin resistance_Homo sapiens_hsa04931-0.0156558
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0129474
99VEGF signaling pathway_Homo sapiens_hsa04370-0.0129131
100Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0102403

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