RPS11P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.22612624
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.11688142
3response to pheromone (GO:0019236)4.08085228
4regulation of posttranscriptional gene silencing (GO:0060147)3.88049544
5regulation of gene silencing by miRNA (GO:0060964)3.88049544
6regulation of gene silencing by RNA (GO:0060966)3.88049544
7L-fucose catabolic process (GO:0042355)3.86982434
8fucose catabolic process (GO:0019317)3.86982434
9L-fucose metabolic process (GO:0042354)3.86982434
10water-soluble vitamin biosynthetic process (GO:0042364)3.59799145
11platelet dense granule organization (GO:0060155)3.53985576
12neuronal action potential (GO:0019228)3.46626621
13nephron epithelium morphogenesis (GO:0072088)3.35125660
14nephron tubule morphogenesis (GO:0072078)3.35125660
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28275490
16negative regulation of telomere maintenance (GO:0032205)3.21111290
17cellular ketone body metabolic process (GO:0046950)3.17679484
18pyrimidine nucleobase catabolic process (GO:0006208)3.15391267
19regulation of cilium movement (GO:0003352)3.15340486
20protein-cofactor linkage (GO:0018065)3.12848455
21regulation of action potential (GO:0098900)3.10428472
22ubiquinone biosynthetic process (GO:0006744)3.04962463
23indole-containing compound catabolic process (GO:0042436)3.03692808
24indolalkylamine catabolic process (GO:0046218)3.03692808
25tryptophan catabolic process (GO:0006569)3.03692808
26indolalkylamine metabolic process (GO:0006586)3.00875190
27gamma-aminobutyric acid transport (GO:0015812)3.00810946
28glycerophospholipid catabolic process (GO:0046475)3.00687358
29DNA deamination (GO:0045006)3.00373801
30negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99754368
31preassembly of GPI anchor in ER membrane (GO:0016254)2.98260804
32negative regulation of mast cell activation (GO:0033004)2.98041559
33kynurenine metabolic process (GO:0070189)2.97221373
34protein complex biogenesis (GO:0070271)2.94323021
35transmission of nerve impulse (GO:0019226)2.93992966
36reflex (GO:0060004)2.93830969
37energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92657196
38ATP synthesis coupled proton transport (GO:0015986)2.92657196
39detection of light stimulus involved in visual perception (GO:0050908)2.92356615
40detection of light stimulus involved in sensory perception (GO:0050962)2.92356615
41peristalsis (GO:0030432)2.88577455
42synaptic transmission, cholinergic (GO:0007271)2.87435637
43histone H4-K12 acetylation (GO:0043983)2.86301555
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.85288540
45NADH dehydrogenase complex assembly (GO:0010257)2.85288540
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85288540
47multicellular organism reproduction (GO:0032504)2.84537056
48ubiquinone metabolic process (GO:0006743)2.84150130
49retinal cone cell development (GO:0046549)2.83757403
50nucleobase catabolic process (GO:0046113)2.82925779
51epithelial cilium movement (GO:0003351)2.82852644
52protein polyglutamylation (GO:0018095)2.78997681
53rhodopsin mediated signaling pathway (GO:0016056)2.78789953
54ketone body metabolic process (GO:1902224)2.77702445
55auditory behavior (GO:0031223)2.77497490
56regulation of neurotransmitter uptake (GO:0051580)2.76606914
57cornea development in camera-type eye (GO:0061303)2.76132812
58phasic smooth muscle contraction (GO:0014821)2.74569344
59renal tubule morphogenesis (GO:0061333)2.74345538
60nonmotile primary cilium assembly (GO:0035058)2.73879257
61behavioral response to ethanol (GO:0048149)2.73786731
62auditory receptor cell stereocilium organization (GO:0060088)2.72141784
63regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71384202
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69877354
65protein localization to cilium (GO:0061512)2.67120032
66piRNA metabolic process (GO:0034587)2.65785824
67membrane depolarization during action potential (GO:0086010)2.65663984
68mitochondrial respiratory chain complex assembly (GO:0033108)2.62776895
69positive regulation of fatty acid transport (GO:2000193)2.61957895
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61359681
71regulation of microtubule-based movement (GO:0060632)2.61133087
72inner ear receptor stereocilium organization (GO:0060122)2.61025192
73tryptophan metabolic process (GO:0006568)2.60345808
74photoreceptor cell development (GO:0042461)2.59604139
75cilium morphogenesis (GO:0060271)2.59076206
76hindbrain development (GO:0030902)2.57539938
77indole-containing compound metabolic process (GO:0042430)2.57038345
78detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56562832
79axoneme assembly (GO:0035082)2.55445169
80respiratory chain complex IV assembly (GO:0008535)2.54327912
81primary amino compound metabolic process (GO:1901160)2.51007165
82somite development (GO:0061053)2.49487123
83positive regulation of protein homodimerization activity (GO:0090073)2.48871193
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47482691
85positive regulation of oligodendrocyte differentiation (GO:0048714)2.45587476
86cellular biogenic amine catabolic process (GO:0042402)2.44731214
87amine catabolic process (GO:0009310)2.44731214
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.44459446
89regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.44459446
90dendritic spine morphogenesis (GO:0060997)2.43813408
91action potential (GO:0001508)2.43510979
92positive regulation of action potential (GO:0045760)2.43463506
93neural tube formation (GO:0001841)2.43062828
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.41655560
95cilium organization (GO:0044782)2.41259411
96parturition (GO:0007567)2.41125429
97mannosylation (GO:0097502)2.41104912
98serotonin metabolic process (GO:0042428)2.40898628
99cellular response to ATP (GO:0071318)2.40686579
100sperm motility (GO:0030317)2.40614676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35376193
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68141142
3VDR_22108803_ChIP-Seq_LS180_Human3.18695204
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81010003
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79665098
6GBX2_23144817_ChIP-Seq_PC3_Human2.50119921
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40576578
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33278986
9IGF1R_20145208_ChIP-Seq_DFB_Human2.17703254
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15810586
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05982528
12FUS_26573619_Chip-Seq_HEK293_Human1.95574330
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95008026
14P300_19829295_ChIP-Seq_ESCs_Human1.90475747
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90387655
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.86341619
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85854354
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81449717
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79025556
20REST_21632747_ChIP-Seq_MESCs_Mouse1.78074967
21EWS_26573619_Chip-Seq_HEK293_Human1.77147094
22ER_23166858_ChIP-Seq_MCF-7_Human1.76580401
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66046984
24BCAT_22108803_ChIP-Seq_LS180_Human1.64978096
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63543962
26TAF15_26573619_Chip-Seq_HEK293_Human1.60411750
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58064677
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.57150707
29TP53_22573176_ChIP-Seq_HFKS_Human1.56144924
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52972140
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.49079809
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44247358
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43841731
34AR_25329375_ChIP-Seq_VCAP_Human1.42562182
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41390160
36CBP_20019798_ChIP-Seq_JUKART_Human1.41390160
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.39580192
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39321749
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38997911
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37863403
41SMAD4_21799915_ChIP-Seq_A2780_Human1.37247594
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37184869
43MYC_18940864_ChIP-ChIP_HL60_Human1.37125560
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37081546
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.36862813
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36816663
47RNF2_27304074_Chip-Seq_NSC_Mouse1.36716544
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32761839
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32528446
50TCF4_23295773_ChIP-Seq_U87_Human1.32475343
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.31526137
52STAT3_23295773_ChIP-Seq_U87_Human1.30833147
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30332783
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30332783
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28662043
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28458804
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28391147
58AR_21572438_ChIP-Seq_LNCaP_Human1.28072229
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.27720048
60SOX2_19829295_ChIP-Seq_ESCs_Human1.26333079
61NANOG_19829295_ChIP-Seq_ESCs_Human1.26333079
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.26193437
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26193437
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.25625768
65IRF1_19129219_ChIP-ChIP_H3396_Human1.24955101
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23995559
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.23053238
68TCF4_22108803_ChIP-Seq_LS180_Human1.22726102
69RUNX2_22187159_ChIP-Seq_PCA_Human1.21061390
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19996186
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19972270
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.19893275
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19248510
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18073793
75AR_20517297_ChIP-Seq_VCAP_Human1.14343924
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.13801763
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12712762
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.11701815
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10969593
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10752239
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10322101
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.09130976
83NCOR_22424771_ChIP-Seq_293T_Human1.08680962
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07609512
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06904910
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06732881
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05178060
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05120492
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04292118
90HOXB7_26014856_ChIP-Seq_BT474_Human1.03494697
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.03265604
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01592507
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01292437
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.01047109
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.00659757
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00650770
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99962159
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.98961038
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.97609024
100TAF2_19829295_ChIP-Seq_ESCs_Human0.97001302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.97490743
2MP0003880_abnormal_central_pattern2.70950874
3MP0001986_abnormal_taste_sensitivity2.64304818
4MP0002638_abnormal_pupillary_reflex2.56446299
5MP0004885_abnormal_endolymph2.54364408
6MP0005551_abnormal_eye_electrophysiolog2.51799549
7MP0002837_dystrophic_cardiac_calcinosis2.37581572
8MP0001968_abnormal_touch/_nociception2.34299970
9MP0003136_yellow_coat_color2.33903417
10MP0002102_abnormal_ear_morphology2.33147293
11MP0003787_abnormal_imprinting2.30925404
12MP0006072_abnormal_retinal_apoptosis2.24575106
13MP0004142_abnormal_muscle_tone2.02189351
14MP0002653_abnormal_ependyma_morphology2.01324338
15MP0003011_delayed_dark_adaptation2.00969473
16MP0004147_increased_porphyrin_level1.98286414
17MP0009745_abnormal_behavioral_response1.96191674
18MP0002272_abnormal_nervous_system1.95124502
19MP0001486_abnormal_startle_reflex1.90832377
20MP0003195_calcinosis1.90636228
21MP0009046_muscle_twitch1.87355928
22MP0008875_abnormal_xenobiotic_pharmacok1.86869198
23MP0002876_abnormal_thyroid_physiology1.78951462
24MP0008872_abnormal_physiological_respon1.78020376
25MP0002736_abnormal_nociception_after1.75156836
26MP0002735_abnormal_chemical_nociception1.72744780
27MP0006292_abnormal_olfactory_placode1.72173728
28MP0001188_hyperpigmentation1.72085772
29MP0005253_abnormal_eye_physiology1.71555807
30MP0005646_abnormal_pituitary_gland1.66506856
31MP0001984_abnormal_olfaction1.65787090
32MP0002733_abnormal_thermal_nociception1.61317986
33MP0005084_abnormal_gallbladder_morpholo1.56983386
34MP0001905_abnormal_dopamine_level1.56014811
35MP0005645_abnormal_hypothalamus_physiol1.54922149
36MP0002572_abnormal_emotion/affect_behav1.50812462
37MP0005423_abnormal_somatic_nervous1.49800760
38MP0002064_seizures1.47576575
39MP0001485_abnormal_pinna_reflex1.45932506
40MP0004742_abnormal_vestibular_system1.42981979
41MP0000427_abnormal_hair_cycle1.41781934
42MP0001970_abnormal_pain_threshold1.41009349
43MP0001501_abnormal_sleep_pattern1.39530367
44MP0003646_muscle_fatigue1.39098454
45MP0003635_abnormal_synaptic_transmissio1.37327408
46MP0004043_abnormal_pH_regulation1.37242591
47MP0005671_abnormal_response_to1.35915337
48MP0005377_hearing/vestibular/ear_phenot1.35231023
49MP0003878_abnormal_ear_physiology1.35231023
50MP0002938_white_spotting1.33841948
51MP0006276_abnormal_autonomic_nervous1.30959355
52MP0002067_abnormal_sensory_capabilities1.30679066
53MP0002063_abnormal_learning/memory/cond1.29911018
54MP0004133_heterotaxia1.28189975
55MP0002734_abnormal_mechanical_nocicepti1.27920549
56MP0005195_abnormal_posterior_eye1.24030857
57MP0002557_abnormal_social/conspecific_i1.23357434
58MP0005386_behavior/neurological_phenoty1.22215287
59MP0004924_abnormal_behavior1.22215287
60MP0002277_abnormal_respiratory_mucosa1.22042018
61MP0000778_abnormal_nervous_system1.21699184
62MP0002909_abnormal_adrenal_gland1.15972443
63MP0000631_abnormal_neuroendocrine_gland1.12673978
64MP0000026_abnormal_inner_ear1.12259079
65MP0002184_abnormal_innervation1.10393486
66MP0005174_abnormal_tail_pigmentation1.09896858
67MP0000569_abnormal_digit_pigmentation1.09571114
68MP0001529_abnormal_vocalization1.08246997
69MP0002160_abnormal_reproductive_system1.06478061
70MP0002752_abnormal_somatic_nervous1.05407863
71MP0004145_abnormal_muscle_electrophysio1.05365793
72MP0002229_neurodegeneration1.04181124
73MP0005389_reproductive_system_phenotype1.02913816
74MP0001293_anophthalmia1.00491172
75MP0002234_abnormal_pharynx_morphology0.99951459
76MP0002928_abnormal_bile_duct0.99011900
77MP0005379_endocrine/exocrine_gland_phen0.98960689
78MP0010386_abnormal_urinary_bladder0.98486945
79MP0001963_abnormal_hearing_physiology0.98362294
80MP0000372_irregular_coat_pigmentation0.96206048
81MP0003121_genomic_imprinting0.95581857
82MP0001440_abnormal_grooming_behavior0.94963425
83MP0000955_abnormal_spinal_cord0.92467735
84MP0001502_abnormal_circadian_rhythm0.92270128
85MP0002163_abnormal_gland_morphology0.92099284
86MP0005075_abnormal_melanosome_morpholog0.91968668
87MP0001919_abnormal_reproductive_system0.87990356
88MP0000230_abnormal_systemic_arterial0.87905022
89MP0001324_abnormal_eye_pigmentation0.87505030
90MP0008775_abnormal_heart_ventricle0.87436365
91MP0004215_abnormal_myocardial_fiber0.87147149
92MP0002882_abnormal_neuron_morphology0.86219065
93MP0002138_abnormal_hepatobiliary_system0.85645277
94MP0002095_abnormal_skin_pigmentation0.80013992
95MP0003122_maternal_imprinting0.79591006
96MP0004019_abnormal_vitamin_homeostasis0.76684281
97MP0005410_abnormal_fertilization0.76486255
98MP0003638_abnormal_response/metabolism_0.76075084
99MP0009780_abnormal_chondrocyte_physiolo0.72766668
100MP0000049_abnormal_middle_ear0.70806728

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.79826389
2Pancreatic cysts (HP:0001737)4.11697378
3Molar tooth sign on MRI (HP:0002419)4.00845554
4Abnormality of midbrain morphology (HP:0002418)4.00845554
5True hermaphroditism (HP:0010459)3.96503159
6Pancreatic fibrosis (HP:0100732)3.95796359
7Nephronophthisis (HP:0000090)3.62794433
8Medial flaring of the eyebrow (HP:0010747)3.51717810
9Abnormality of the renal cortex (HP:0011035)3.19368475
10Stomach cancer (HP:0012126)3.15133895
11Hyperventilation (HP:0002883)3.14604081
12Gait imbalance (HP:0002141)3.07212358
13Abnormality of the renal medulla (HP:0100957)3.03801661
14Large for gestational age (HP:0001520)3.02551570
15Congenital primary aphakia (HP:0007707)2.87404469
16Type II lissencephaly (HP:0007260)2.79524543
17Renal cortical cysts (HP:0000803)2.71746467
183-Methylglutaconic aciduria (HP:0003535)2.71183725
19Abnormal rod and cone electroretinograms (HP:0008323)2.64746148
20Nephrogenic diabetes insipidus (HP:0009806)2.64074174
21Congenital, generalized hypertrichosis (HP:0004540)2.55681753
22Progressive cerebellar ataxia (HP:0002073)2.55349533
23Abolished electroretinogram (ERG) (HP:0000550)2.55001116
24Sclerocornea (HP:0000647)2.54426151
25Vaginal atresia (HP:0000148)2.53862601
26Aplasia/Hypoplasia of the spleen (HP:0010451)2.53396246
27Cystic liver disease (HP:0006706)2.53054559
28Genital tract atresia (HP:0001827)2.52915241
29Chronic hepatic failure (HP:0100626)2.42351794
30Broad-based gait (HP:0002136)2.41379259
31Methylmalonic acidemia (HP:0002912)2.37543177
32Pachygyria (HP:0001302)2.37173412
33Asplenia (HP:0001746)2.36417038
34Anencephaly (HP:0002323)2.34043867
35Attenuation of retinal blood vessels (HP:0007843)2.32140407
36Hemiparesis (HP:0001269)2.29046552
37Inability to walk (HP:0002540)2.28650813
38Tubular atrophy (HP:0000092)2.26545420
39Polydipsia (HP:0001959)2.25419284
40Abnormal drinking behavior (HP:0030082)2.25419284
41Focal motor seizures (HP:0011153)2.23145588
42Furrowed tongue (HP:0000221)2.18768005
43Abnormal respiratory motile cilium morphology (HP:0005938)2.17055351
44Abnormal respiratory epithelium morphology (HP:0012253)2.17055351
45Absent/shortened dynein arms (HP:0200106)2.15460715
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.15460715
47Methylmalonic aciduria (HP:0012120)2.12405429
48Lissencephaly (HP:0001339)2.12201098
49Abnormality of the labia minora (HP:0012880)2.11900270
50Pendular nystagmus (HP:0012043)2.09015783
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07444757
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07167777
53Abnormality of alanine metabolism (HP:0010916)2.07167777
54Hyperalaninemia (HP:0003348)2.07167777
55Mitochondrial inheritance (HP:0001427)2.05335307
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.05317647
57Increased corneal curvature (HP:0100692)2.05309470
58Keratoconus (HP:0000563)2.05309470
59Aplasia/hypoplasia of the uterus (HP:0008684)2.02756271
60Acute necrotizing encephalopathy (HP:0006965)2.01912721
61Male pseudohermaphroditism (HP:0000037)1.99697648
62Tachypnea (HP:0002789)1.98194099
63Increased CSF lactate (HP:0002490)1.97676012
64Severe muscular hypotonia (HP:0006829)1.96907744
65Concave nail (HP:0001598)1.96889544
66Poor coordination (HP:0002370)1.96708026
67Polyphagia (HP:0002591)1.95248554
68Progressive inability to walk (HP:0002505)1.94402334
69Oligodactyly (hands) (HP:0001180)1.92959593
70Polyuria (HP:0000103)1.92067024
71Postaxial foot polydactyly (HP:0001830)1.91258064
72Congenital hepatic fibrosis (HP:0002612)1.91096721
73Optic disc pallor (HP:0000543)1.89915373
74Gaze-evoked nystagmus (HP:0000640)1.89388452
75Febrile seizures (HP:0002373)1.87788116
76Abnormal ciliary motility (HP:0012262)1.87283382
77Progressive macrocephaly (HP:0004481)1.87005481
78Acute encephalopathy (HP:0006846)1.86354376
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85795224
80Postaxial hand polydactyly (HP:0001162)1.85294055
81Decreased circulating renin level (HP:0003351)1.84229757
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83962137
83Limb dystonia (HP:0002451)1.83469655
84Hyperglycinemia (HP:0002154)1.82838323
85Abnormality of the pons (HP:0007361)1.78533392
86Optic nerve hypoplasia (HP:0000609)1.78309442
87Hypothermia (HP:0002045)1.78232963
88Decreased central vision (HP:0007663)1.78063420
89Focal seizures (HP:0007359)1.76059351
90Agitation (HP:0000713)1.76050459
91Specific learning disability (HP:0001328)1.75279780
92Bile duct proliferation (HP:0001408)1.75156478
93Abnormal biliary tract physiology (HP:0012439)1.75156478
94Bony spicule pigmentary retinopathy (HP:0007737)1.73880571
95Abnormal mitochondria in muscle tissue (HP:0008316)1.71063545
96Supernumerary spleens (HP:0009799)1.70864638
97Increased serum lactate (HP:0002151)1.70544906
98Hepatocellular necrosis (HP:0001404)1.70345519
99Abnormal number of erythroid precursors (HP:0012131)1.69298426
100Nephrotic syndrome (HP:0000100)1.69158137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.74728995
2ADRBK23.58474728
3GRK13.27657589
4TAOK33.26381307
5CASK3.13317821
6WNK43.06045255
7ZAK2.87485369
8PINK12.85382321
9TLK12.83568496
10BMPR1B2.30274191
11MAP4K22.15282138
12WNK32.12212568
13STK161.95218758
14MAP3K41.79451817
15MAPK131.77627773
16PNCK1.62978741
17NUAK11.59204097
18TXK1.56926325
19AKT31.56855052
20INSRR1.43594173
21MUSK1.42837128
22MARK11.42027889
23STK391.41673692
24DYRK21.41463509
25TNIK1.32566493
26ACVR1B1.29047599
27PAK31.27989540
28OXSR11.26424429
29IRAK41.26169094
30EPHA31.23472633
31VRK11.13217952
32NTRK31.12072038
33NTRK21.11897688
34PHKG21.06993457
35PHKG11.06993457
36CAMKK21.05450405
37TAF10.98256174
38BCKDK0.97734941
39TIE10.95088224
40MAP2K70.95038464
41TESK20.94603728
42PRKCG0.94267204
43ADRBK10.93161924
44KIT0.92512341
45DAPK20.90767944
46MAPK150.86795662
47PRKCE0.84443568
48FGFR20.74768191
49MARK30.72817182
50PTK2B0.71950884
51ERBB30.69048237
52TGFBR10.67825708
53TRIM280.67156563
54SIK20.65934026
55PLK20.65752155
56VRK20.64960092
57MAPKAPK30.63963806
58IKBKB0.63623867
59PKN10.62171058
60NME10.61347366
61WNK10.60455990
62CDK190.60270685
63RPS6KA50.59993989
64MAP2K20.59773007
65PRKCQ0.58733826
66PRKCI0.57098155
67PIK3CA0.54615263
68CAMK2A0.53190645
69PRKACA0.53092753
70CSNK1G20.50503921
71PRKCZ0.48830136
72NLK0.48596976
73SYK0.48033807
74CSNK1G10.46734750
75ITK0.45158027
76MAP2K60.42294264
77STK110.42018852
78TEC0.41915905
79CAMKK10.41394698
80CAMK2D0.40991667
81IRAK10.40452102
82STK38L0.38411624
83OBSCN0.37745413
84MKNK20.37393968
85ILK0.37076982
86CSNK1G30.35603069
87MAP2K40.35356232
88BRSK20.35298936
89PIK3CG0.35018886
90SGK20.34916699
91SGK2230.34511045
92SGK4940.34511045
93PASK0.34452690
94MAPKAPK50.34337971
95TNK20.34316771
96PRKG10.33165922
97HIPK20.33017144
98PLK30.32040671
99GRK60.31797731
100PIM10.30712624

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.07405139
2Oxidative phosphorylation_Homo sapiens_hsa001902.61027277
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58943320
4Nitrogen metabolism_Homo sapiens_hsa009102.46728033
5Linoleic acid metabolism_Homo sapiens_hsa005912.42387189
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.42126983
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27351947
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24832164
9Nicotine addiction_Homo sapiens_hsa050332.21162292
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.15626342
11Selenocompound metabolism_Homo sapiens_hsa004502.12708917
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01433862
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99427728
14Parkinsons disease_Homo sapiens_hsa050121.99371462
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97621663
16Butanoate metabolism_Homo sapiens_hsa006501.92455238
17Ether lipid metabolism_Homo sapiens_hsa005651.67738638
18Cardiac muscle contraction_Homo sapiens_hsa042601.66395759
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61227241
20Caffeine metabolism_Homo sapiens_hsa002321.59684178
21Tryptophan metabolism_Homo sapiens_hsa003801.55486722
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54977898
23Taste transduction_Homo sapiens_hsa047421.54004195
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46988333
25Protein export_Homo sapiens_hsa030601.46636493
26Morphine addiction_Homo sapiens_hsa050321.45869470
27Basal transcription factors_Homo sapiens_hsa030221.40205383
28Steroid biosynthesis_Homo sapiens_hsa001001.39620996
29Regulation of autophagy_Homo sapiens_hsa041401.39527494
30Alzheimers disease_Homo sapiens_hsa050101.33627922
31Olfactory transduction_Homo sapiens_hsa047401.27853524
32RNA polymerase_Homo sapiens_hsa030201.26837086
33Insulin secretion_Homo sapiens_hsa049111.23992467
34Ribosome_Homo sapiens_hsa030101.23559927
35Propanoate metabolism_Homo sapiens_hsa006401.22240472
36Huntingtons disease_Homo sapiens_hsa050161.18785905
37GABAergic synapse_Homo sapiens_hsa047271.17677055
38Glutamatergic synapse_Homo sapiens_hsa047241.16769428
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.16245128
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15900379
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.15351059
42Circadian entrainment_Homo sapiens_hsa047131.15143980
43Serotonergic synapse_Homo sapiens_hsa047261.13220095
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11700250
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07798666
46Ovarian steroidogenesis_Homo sapiens_hsa049131.06641837
47Peroxisome_Homo sapiens_hsa041461.05426310
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02217766
49Chemical carcinogenesis_Homo sapiens_hsa052040.95979207
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94356592
51Homologous recombination_Homo sapiens_hsa034400.93221807
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91570509
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89698090
54RNA degradation_Homo sapiens_hsa030180.87763144
55Collecting duct acid secretion_Homo sapiens_hsa049660.87048540
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84922520
57Primary immunodeficiency_Homo sapiens_hsa053400.84749611
58Retinol metabolism_Homo sapiens_hsa008300.83545618
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.82585456
60One carbon pool by folate_Homo sapiens_hsa006700.80604146
61Fanconi anemia pathway_Homo sapiens_hsa034600.79379742
62ABC transporters_Homo sapiens_hsa020100.78531320
63beta-Alanine metabolism_Homo sapiens_hsa004100.78316832
64Salivary secretion_Homo sapiens_hsa049700.77221606
65Dopaminergic synapse_Homo sapiens_hsa047280.72884569
66Glycerolipid metabolism_Homo sapiens_hsa005610.72333605
67Asthma_Homo sapiens_hsa053100.71413840
68Type I diabetes mellitus_Homo sapiens_hsa049400.68646549
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68402579
70Fat digestion and absorption_Homo sapiens_hsa049750.68304467
71Cocaine addiction_Homo sapiens_hsa050300.64606999
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63394213
73Calcium signaling pathway_Homo sapiens_hsa040200.62570215
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60460747
75Amphetamine addiction_Homo sapiens_hsa050310.59736278
76Hedgehog signaling pathway_Homo sapiens_hsa043400.59591376
77Fatty acid elongation_Homo sapiens_hsa000620.59557868
78Purine metabolism_Homo sapiens_hsa002300.57017046
79Sulfur relay system_Homo sapiens_hsa041220.57007908
80Metabolic pathways_Homo sapiens_hsa011000.55288758
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52373541
82Proteasome_Homo sapiens_hsa030500.52225685
83Sulfur metabolism_Homo sapiens_hsa009200.51372436
84Long-term depression_Homo sapiens_hsa047300.51323108
85Oxytocin signaling pathway_Homo sapiens_hsa049210.50636836
86Histidine metabolism_Homo sapiens_hsa003400.49905593
87Renin secretion_Homo sapiens_hsa049240.46867302
88cAMP signaling pathway_Homo sapiens_hsa040240.45707474
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45296917
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.45056511
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44088102
92Pyrimidine metabolism_Homo sapiens_hsa002400.42536758
93Basal cell carcinoma_Homo sapiens_hsa052170.42196060
94Mineral absorption_Homo sapiens_hsa049780.41601406
95Cholinergic synapse_Homo sapiens_hsa047250.41011059
96Gastric acid secretion_Homo sapiens_hsa049710.40910062
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38892753
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37548578
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31515637
100Dorso-ventral axis formation_Homo sapiens_hsa043200.29495642

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