RPS10P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.78765466
2ribosomal small subunit biogenesis (GO:0042274)8.15415732
3viral transcription (GO:0019083)7.94773970
4translational termination (GO:0006415)7.66886822
5maturation of SSU-rRNA (GO:0030490)6.99885905
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.59152342
7translational elongation (GO:0006414)6.59009506
8cotranslational protein targeting to membrane (GO:0006613)6.49570409
9protein targeting to ER (GO:0045047)6.43951045
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.19067231
11protein localization to endoplasmic reticulum (GO:0070972)6.03878769
12cellular protein complex disassembly (GO:0043624)5.81196370
13viral life cycle (GO:0019058)5.73340335
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.59934964
15ATP synthesis coupled proton transport (GO:0015986)5.47760349
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.47760349
17translational initiation (GO:0006413)5.22193651
18ribosomal large subunit biogenesis (GO:0042273)5.21061845
19chaperone-mediated protein transport (GO:0072321)5.08273428
20protein complex disassembly (GO:0043241)4.86575061
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84082385
22macromolecular complex disassembly (GO:0032984)4.59743864
23translation (GO:0006412)4.51554973
24ribonucleoprotein complex biogenesis (GO:0022613)4.45406278
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.39295107
26protein targeting to membrane (GO:0006612)4.33469921
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.24338591
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22689923
29cellular component biogenesis (GO:0044085)4.20575370
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.19676567
31NADH dehydrogenase complex assembly (GO:0010257)4.19676567
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19676567
33protein neddylation (GO:0045116)4.19028828
34protein complex biogenesis (GO:0070271)4.11276192
35base-excision repair, AP site formation (GO:0006285)4.08525365
36nuclear-transcribed mRNA catabolic process (GO:0000956)4.03760244
37GTP biosynthetic process (GO:0006183)3.99899832
38respiratory electron transport chain (GO:0022904)3.98599772
39electron transport chain (GO:0022900)3.97001155
40behavioral response to nicotine (GO:0035095)3.90013007
41mRNA catabolic process (GO:0006402)3.82251264
42mitochondrial respiratory chain complex assembly (GO:0033108)3.69553936
43pyrimidine nucleotide catabolic process (GO:0006244)3.68794407
44ncRNA 3-end processing (GO:0043628)3.59079355
45ubiquinone biosynthetic process (GO:0006744)3.58888473
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57698801
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57698801
48rRNA processing (GO:0006364)3.51421122
49DNA deamination (GO:0045006)3.48771085
50pseudouridine synthesis (GO:0001522)3.48134786
51RNA catabolic process (GO:0006401)3.44554357
52UTP biosynthetic process (GO:0006228)3.44358878
53rRNA metabolic process (GO:0016072)3.43755418
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.41464769
55water-soluble vitamin biosynthetic process (GO:0042364)3.39662025
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.37702798
57peptidyl-histidine modification (GO:0018202)3.37237417
58transcription elongation from RNA polymerase III promoter (GO:0006385)3.35744537
59termination of RNA polymerase III transcription (GO:0006386)3.35744537
60ubiquinone metabolic process (GO:0006743)3.28332264
61ATP biosynthetic process (GO:0006754)3.23011591
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18754658
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15278962
64CTP metabolic process (GO:0046036)3.12107337
65CTP biosynthetic process (GO:0006241)3.12107337
66protein polyglutamylation (GO:0018095)3.10778299
67hydrogen ion transmembrane transport (GO:1902600)3.09372519
68respiratory chain complex IV assembly (GO:0008535)3.08784394
69protein targeting to mitochondrion (GO:0006626)3.08584314
70ribonucleoside triphosphate biosynthetic process (GO:0009201)3.08180940
71UTP metabolic process (GO:0046051)3.07834886
72protein targeting (GO:0006605)3.05463643
73negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.04417744
74pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99786098
75rRNA modification (GO:0000154)2.96358561
76establishment of protein localization to membrane (GO:0090150)2.95775837
77intracellular protein transmembrane import (GO:0044743)2.94357994
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93387530
79ribosome biogenesis (GO:0042254)2.92056132
80protein-cofactor linkage (GO:0018065)2.89610829
81tRNA processing (GO:0008033)2.89215894
82establishment of protein localization to mitochondrion (GO:0072655)2.88681617
83RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.87088929
84metallo-sulfur cluster assembly (GO:0031163)2.86660498
85iron-sulfur cluster assembly (GO:0016226)2.86660498
86proton transport (GO:0015992)2.86355301
87deoxyribonucleotide catabolic process (GO:0009264)2.83556205
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81502751
89deoxyribose phosphate catabolic process (GO:0046386)2.81339003
90quinone biosynthetic process (GO:1901663)2.79813953
91hydrogen transport (GO:0006818)2.79788142
92establishment of protein localization to organelle (GO:0072594)2.78854097
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.76871787
94guanosine-containing compound biosynthetic process (GO:1901070)2.76111023
95ncRNA processing (GO:0034470)2.74615274
96preassembly of GPI anchor in ER membrane (GO:0016254)2.70740848
97protein localization to mitochondrion (GO:0070585)2.69346543
98negative regulation of T cell differentiation in thymus (GO:0033085)2.68659732
99nucleoside triphosphate biosynthetic process (GO:0009142)2.67567492
100cell proliferation in forebrain (GO:0021846)2.67361553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.51001322
2EZH2_22144423_ChIP-Seq_EOC_Human4.30411621
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74096237
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.65893775
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61033138
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.44916697
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43492643
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27969457
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.11678479
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80601875
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77012574
12VDR_22108803_ChIP-Seq_LS180_Human2.53979556
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43759344
14VDR_23849224_ChIP-Seq_CD4+_Human2.23894724
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23560850
16FOXP3_21729870_ChIP-Seq_TREG_Human2.19529784
17ZNF274_21170338_ChIP-Seq_K562_Hela2.17021818
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12579515
19IRF1_19129219_ChIP-ChIP_H3396_Human2.10426111
20TTF2_22483619_ChIP-Seq_HELA_Human2.06073907
21XRN2_22483619_ChIP-Seq_HELA_Human1.96739409
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.91609199
23MYC_18940864_ChIP-ChIP_HL60_Human1.90617568
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90314918
25GABP_19822575_ChIP-Seq_HepG2_Human1.88923377
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86680894
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85428096
28ELK1_19687146_ChIP-ChIP_HELA_Human1.82846292
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78308305
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77685358
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.74996160
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73415750
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72684847
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61356678
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56887491
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56705166
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55236380
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53274038
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.38263940
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38026681
41TP53_22573176_ChIP-Seq_HFKS_Human1.34671790
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31213719
43IGF1R_20145208_ChIP-Seq_DFB_Human1.31208649
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28380909
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27114621
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25474961
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.23129190
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23039201
49EWS_26573619_Chip-Seq_HEK293_Human1.21325557
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19647282
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19156110
52DCP1A_22483619_ChIP-Seq_HELA_Human1.16811742
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16258807
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16051915
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15301678
56ERA_21632823_ChIP-Seq_H3396_Human1.12922132
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.12508547
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12251939
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11867567
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10771971
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10092058
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.09920186
63NANOG_20526341_ChIP-Seq_ESCs_Human1.09783511
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.09547716
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08185356
66NCOR_22424771_ChIP-Seq_293T_Human1.07884375
67TAF2_19829295_ChIP-Seq_ESCs_Human1.07442123
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07278066
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04387963
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.04330544
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03796807
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02533019
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02074741
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00838825
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.00697921
76CTCF_20526341_ChIP-Seq_ESCs_Human1.00078578
77STAT1_20625510_ChIP-Seq_HELA_Human0.98106126
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97943385
79KDM5A_27292631_Chip-Seq_BREAST_Human0.96210687
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94826705
81AR_20517297_ChIP-Seq_VCAP_Human0.93391318
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93093249
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92152164
84E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92013619
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.91914729
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88759013
87HOXB7_26014856_ChIP-Seq_BT474_Human0.88452064
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87723963
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87701619
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87310525
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.87098115
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86668678
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.86462354
94BCL6_27268052_Chip-Seq_Bcells_Human0.85873868
95RNF2_27304074_Chip-Seq_NSC_Mouse0.85822621
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85794624
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.83940102
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83837850
99FUS_26573619_Chip-Seq_HEK293_Human0.83313077
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83112914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.12048105
2MP0006292_abnormal_olfactory_placode4.26451785
3MP0002163_abnormal_gland_morphology2.81800985
4MP0003787_abnormal_imprinting2.50696386
5MP0005646_abnormal_pituitary_gland2.35653631
6MP0002653_abnormal_ependyma_morphology2.34956538
7MP0008877_abnormal_DNA_methylation2.31486721
8MP0003878_abnormal_ear_physiology2.27269878
9MP0005377_hearing/vestibular/ear_phenot2.27269878
10MP0008789_abnormal_olfactory_epithelium2.16911817
11MP0004142_abnormal_muscle_tone2.09808791
12MP0003123_paternal_imprinting1.97052275
13MP0002638_abnormal_pupillary_reflex1.96626082
14MP0002102_abnormal_ear_morphology1.94579129
15MP0001986_abnormal_taste_sensitivity1.83617821
16MP0008058_abnormal_DNA_repair1.79985937
17MP0006276_abnormal_autonomic_nervous1.74996006
18MP0005394_taste/olfaction_phenotype1.74472050
19MP0005499_abnormal_olfactory_system1.74472050
20MP0004885_abnormal_endolymph1.74322317
21MP0005379_endocrine/exocrine_gland_phen1.72762432
22MP0003186_abnormal_redox_activity1.69496871
23MP0008872_abnormal_physiological_respon1.65926205
24MP0003122_maternal_imprinting1.65509073
25MP0001968_abnormal_touch/_nociception1.62714274
26MP0000049_abnormal_middle_ear1.59673629
27MP0002938_white_spotting1.57842589
28MP0001293_anophthalmia1.55948537
29MP0003786_premature_aging1.53526127
30MP0003646_muscle_fatigue1.53503841
31MP0005389_reproductive_system_phenotype1.51503787
32MP0002095_abnormal_skin_pigmentation1.50683222
33MP0004147_increased_porphyrin_level1.50519676
34MP0002234_abnormal_pharynx_morphology1.48999797
35MP0002160_abnormal_reproductive_system1.48814042
36MP0006072_abnormal_retinal_apoptosis1.47312892
37MP0005075_abnormal_melanosome_morpholog1.47240244
38MP0002138_abnormal_hepatobiliary_system1.47186743
39MP0001485_abnormal_pinna_reflex1.45068317
40MP0002837_dystrophic_cardiac_calcinosis1.43519873
41MP0000372_irregular_coat_pigmentation1.40464790
42MP0001919_abnormal_reproductive_system1.40177844
43MP0002876_abnormal_thyroid_physiology1.39528440
44MP0003121_genomic_imprinting1.37775335
45MP0004742_abnormal_vestibular_system1.37118426
46MP0005551_abnormal_eye_electrophysiolog1.36866740
47MP0004145_abnormal_muscle_electrophysio1.36831965
48MP0000631_abnormal_neuroendocrine_gland1.33487468
49MP0001529_abnormal_vocalization1.32353799
50MP0002272_abnormal_nervous_system1.31937818
51MP0008875_abnormal_xenobiotic_pharmacok1.31586611
52MP0002736_abnormal_nociception_after1.31200044
53MP0010030_abnormal_orbit_morphology1.19890854
54MP0003136_yellow_coat_color1.16591460
55MP0001905_abnormal_dopamine_level1.14699600
56MP0005174_abnormal_tail_pigmentation1.13771481
57MP0001502_abnormal_circadian_rhythm1.12017419
58MP0008995_early_reproductive_senescence1.10474013
59MP0009745_abnormal_behavioral_response1.10212359
60MP0003693_abnormal_embryo_hatching1.07971606
61MP0003880_abnormal_central_pattern1.07394431
62MP0000778_abnormal_nervous_system1.06819263
63MP0004133_heterotaxia1.04141283
64MP0002210_abnormal_sex_determination1.04012032
65MP0003195_calcinosis1.02986370
66MP0006036_abnormal_mitochondrial_physio1.02680324
67MP0005645_abnormal_hypothalamus_physiol1.02598054
68MP0001984_abnormal_olfaction1.01099359
69MP0003879_abnormal_hair_cell1.00062959
70MP0005195_abnormal_posterior_eye1.00050615
71MP0002277_abnormal_respiratory_mucosa0.98092590
72MP0001440_abnormal_grooming_behavior0.97685342
73MP0003567_abnormal_fetal_cardiomyocyte0.97322313
74MP0000026_abnormal_inner_ear0.96276914
75MP0009046_muscle_twitch0.96125576
76MP0002733_abnormal_thermal_nociception0.93826438
77MP0003011_delayed_dark_adaptation0.88811558
78MP0001970_abnormal_pain_threshold0.87858759
79MP0002752_abnormal_somatic_nervous0.87782476
80MP0000015_abnormal_ear_pigmentation0.85796449
81MP0003937_abnormal_limbs/digits/tail_de0.85581758
82MP0006035_abnormal_mitochondrial_morpho0.84187127
83MP0000653_abnormal_sex_gland0.83302120
84MP0002557_abnormal_social/conspecific_i0.81804112
85MP0001145_abnormal_male_reproductive0.81492155
86MP0003938_abnormal_ear_development0.80563302
87MP0003936_abnormal_reproductive_system0.79748589
88MP0001963_abnormal_hearing_physiology0.78484773
89MP0000613_abnormal_salivary_gland0.77741840
90MP0000566_synostosis0.77588719
91MP0002572_abnormal_emotion/affect_behav0.75438479
92MP0001188_hyperpigmentation0.74950927
93MP0001929_abnormal_gametogenesis0.73789791
94MP0002184_abnormal_innervation0.73489890
95MP0008775_abnormal_heart_ventricle0.71968701
96MP0003718_maternal_effect0.70599495
97MP0005636_abnormal_mineral_homeostasis0.69873165
98MP0002233_abnormal_nose_morphology0.69416269
99MP0005084_abnormal_gallbladder_morpholo0.68819822
100MP0005253_abnormal_eye_physiology0.68140422

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.59256322
2Acute necrotizing encephalopathy (HP:0006965)5.11216646
3Abnormality of cells of the erythroid lineage (HP:0012130)4.64592783
4Abnormal mitochondria in muscle tissue (HP:0008316)4.57740601
5Acute encephalopathy (HP:0006846)4.56382375
6Progressive macrocephaly (HP:0004481)4.12281026
7Mitochondrial inheritance (HP:0001427)4.09559135
8Increased CSF lactate (HP:0002490)3.89358499
9Macrocytic anemia (HP:0001972)3.79996458
10Pancreatic fibrosis (HP:0100732)3.64799672
11Molar tooth sign on MRI (HP:0002419)3.58264322
12Abnormality of midbrain morphology (HP:0002418)3.58264322
13Abnormal number of erythroid precursors (HP:0012131)3.52430201
14Pallor (HP:0000980)3.39778643
15Pancreatic cysts (HP:0001737)3.38890144
16Hepatocellular necrosis (HP:0001404)3.33755610
17Congenital stationary night blindness (HP:0007642)3.24813503
18True hermaphroditism (HP:0010459)3.18862440
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14826395
20Cerebral edema (HP:0002181)3.14485048
21Colon cancer (HP:0003003)3.10306784
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.09599084
23Hepatic necrosis (HP:0002605)3.07551103
243-Methylglutaconic aciduria (HP:0003535)2.98001419
25Absent thumb (HP:0009777)2.82343730
26Abnormal rod and cone electroretinograms (HP:0008323)2.81752687
27Increased hepatocellular lipid droplets (HP:0006565)2.80021825
28Sclerocornea (HP:0000647)2.78226609
29Optic disc pallor (HP:0000543)2.74496088
30Abnormal hemoglobin (HP:0011902)2.64456260
31Nephronophthisis (HP:0000090)2.62952640
32Septo-optic dysplasia (HP:0100842)2.59144532
33Increased serum lactate (HP:0002151)2.59026220
34Lactic acidosis (HP:0003128)2.57566607
35Lipid accumulation in hepatocytes (HP:0006561)2.55000992
36Hyperglycinemia (HP:0002154)2.49864485
37Anencephaly (HP:0002323)2.49059650
38Increased intramyocellular lipid droplets (HP:0012240)2.47006536
39Renal Fanconi syndrome (HP:0001994)2.46848650
40Pendular nystagmus (HP:0012043)2.40921090
41Stenosis of the external auditory canal (HP:0000402)2.39160733
42Type II lissencephaly (HP:0007260)2.38797367
43Medial flaring of the eyebrow (HP:0010747)2.35338706
44Asplenia (HP:0001746)2.27862509
45Aplasia/Hypoplasia of the spleen (HP:0010451)2.27436485
46Abnormality of the renal medulla (HP:0100957)2.23873143
47Respiratory failure (HP:0002878)2.23683776
48Microretrognathia (HP:0000308)2.21081421
49Cystic liver disease (HP:0006706)2.18431475
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18191808
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18191808
52Leukodystrophy (HP:0002415)2.14884472
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12093446
54Male pseudohermaphroditism (HP:0000037)2.08704128
55Lethargy (HP:0001254)2.08657567
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06693134
57Postaxial foot polydactyly (HP:0001830)2.06219848
58Abnormality of the labia minora (HP:0012880)2.05594320
59Exercise intolerance (HP:0003546)2.00443659
60Abnormality of the renal cortex (HP:0011035)1.99960703
61Hypoplasia of the radius (HP:0002984)1.99860046
62Increased muscle lipid content (HP:0009058)1.99151658
63Depressed nasal ridge (HP:0000457)1.98434068
64Rib fusion (HP:0000902)1.91329380
65Abnormality of alanine metabolism (HP:0010916)1.89035681
66Hyperalaninemia (HP:0003348)1.89035681
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89035681
68Aplasia/hypoplasia of the uterus (HP:0008684)1.86947879
69Exertional dyspnea (HP:0002875)1.85873357
70Abnormality of the anterior horn cell (HP:0006802)1.81012262
71Degeneration of anterior horn cells (HP:0002398)1.81012262
72Abnormality of DNA repair (HP:0003254)1.80958741
73Abolished electroretinogram (ERG) (HP:0000550)1.80024083
74Optic nerve coloboma (HP:0000588)1.78625248
75Triphalangeal thumb (HP:0001199)1.78561331
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78388412
77Hypoplasia of the ulna (HP:0003022)1.75868538
78Tubular atrophy (HP:0000092)1.75365499
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.75142127
80Horseshoe kidney (HP:0000085)1.74327269
81Gait imbalance (HP:0002141)1.72678318
82Abnormality of renal resorption (HP:0011038)1.71804460
83Type 2 muscle fiber atrophy (HP:0003554)1.70948436
84Congenital primary aphakia (HP:0007707)1.70802299
85Symphalangism affecting the phalanges of the hand (HP:0009773)1.70268905
86Constricted visual fields (HP:0001133)1.69945419
87Glycosuria (HP:0003076)1.69664764
88Abnormality of urine glucose concentration (HP:0011016)1.69664764
89Nephrogenic diabetes insipidus (HP:0009806)1.69206674
90Hyperthyroidism (HP:0000836)1.69114437
91Preaxial hand polydactyly (HP:0001177)1.67541473
92Maternal diabetes (HP:0009800)1.67465055
93Holoprosencephaly (HP:0001360)1.66918391
94Forearm undergrowth (HP:0009821)1.64806704
95Congenital hepatic fibrosis (HP:0002612)1.64743929
96Partial duplication of thumb phalanx (HP:0009944)1.64576282
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.63497940
98Pachygyria (HP:0001302)1.62843984
99Humeroradial synostosis (HP:0003041)1.62634311
100Synostosis involving the elbow (HP:0003938)1.62634311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.71726824
2CDK193.01739288
3WNK42.99222881
4PINK12.82388482
5VRK22.68892742
6BCKDK2.60762808
7ADRBK22.38484436
8NME22.29029916
9PIK3CA2.28949018
10GRK12.28399293
11ZAK2.16317153
12TLK12.13212322
13CDC72.06468360
14DYRK22.04505680
15MAP4K22.00941102
16STK161.98746518
17PDK21.91621285
18NEK11.87022292
19LRRK21.81957547
20PASK1.53685297
21CAMKK21.46667417
22STK391.46019684
23TXK1.37684880
24MAP3K111.29459680
25WNK31.28313630
26PLK41.27213843
27VRK11.26868423
28SRPK11.25653381
29NME11.24217403
30ABL21.11342455
31BMPR1B1.07006017
32BRAF1.05405307
33PRKCG1.04564300
34DMPK1.03733844
35PAK30.92243829
36CAMK10.90187895
37OXSR10.89945505
38ADRBK10.88993822
39CSNK1G20.88468650
40PRKCQ0.88363662
41TAOK30.87792878
42FRK0.87533683
43BUB10.85788906
44AURKB0.83173815
45IKBKB0.82245072
46MATK0.78550701
47CSNK2A20.77644172
48CSNK1G30.77182841
49TEC0.76884878
50TIE10.76453858
51LIMK10.76215710
52PRKCI0.74950919
53INSRR0.73569502
54RPS6KA50.72647107
55PLK10.72240203
56AURKA0.71929474
57PHKG10.71771395
58PHKG20.71771395
59WNK10.69266368
60ACVR1B0.68276234
61CAMKK10.65089155
62DAPK30.64549180
63CSNK2A10.64320592
64TAF10.64265166
65STK110.62558361
66PRKACA0.60609779
67ITK0.57261043
68ATR0.54040535
69NTRK20.53315064
70MAPK130.51770781
71MINK10.51686992
72PRKCH0.50644333
73PLK20.50515108
74PRKCE0.49300810
75CSNK1G10.49185518
76PLK30.48884309
77MKNK20.48593382
78NTRK10.47931117
79CHEK20.47532255
80EPHA40.45910088
81ARAF0.45107691
82RPS6KA60.44327051
83CSNK1E0.43867970
84PRKCD0.43618321
85MUSK0.43102498
86PRKCA0.42958935
87MAP2K20.42943966
88CSNK1A1L0.42798118
89TYRO30.42771362
90EPHB20.40678696
91PIM20.39970201
92KIT0.37681126
93CAMK2A0.37043124
94NEK20.35369093
95OBSCN0.34207158
96CAMK2D0.34055419
97TGFBR10.34044749
98CDK80.33662988
99MAP2K70.31217935
100GRK50.31160199

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.62545123
2Oxidative phosphorylation_Homo sapiens_hsa001904.22219993
3Parkinsons disease_Homo sapiens_hsa050123.50431941
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.03390914
5RNA polymerase_Homo sapiens_hsa030202.82922341
6Proteasome_Homo sapiens_hsa030502.58107680
7Huntingtons disease_Homo sapiens_hsa050162.50920763
8Alzheimers disease_Homo sapiens_hsa050102.29125784
9Cardiac muscle contraction_Homo sapiens_hsa042602.26039534
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15498864
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11753267
12Protein export_Homo sapiens_hsa030602.07785265
13One carbon pool by folate_Homo sapiens_hsa006701.95271973
14Base excision repair_Homo sapiens_hsa034101.83655251
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78095379
16Pyrimidine metabolism_Homo sapiens_hsa002401.62039061
17Homologous recombination_Homo sapiens_hsa034401.59339616
18Nucleotide excision repair_Homo sapiens_hsa034201.57400498
19Asthma_Homo sapiens_hsa053101.55811606
20Basal transcription factors_Homo sapiens_hsa030221.54824519
21RNA degradation_Homo sapiens_hsa030181.52518744
22Fanconi anemia pathway_Homo sapiens_hsa034601.40179588
23Mismatch repair_Homo sapiens_hsa034301.36264636
24Linoleic acid metabolism_Homo sapiens_hsa005911.34407169
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28699888
26DNA replication_Homo sapiens_hsa030301.27175862
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25131813
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22597383
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21167125
30Phototransduction_Homo sapiens_hsa047441.20023508
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19447525
32Nitrogen metabolism_Homo sapiens_hsa009101.18318843
33Propanoate metabolism_Homo sapiens_hsa006401.14797703
34Peroxisome_Homo sapiens_hsa041461.14665756
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.13030905
36Sulfur relay system_Homo sapiens_hsa041221.08853916
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07778618
38RNA transport_Homo sapiens_hsa030131.03042177
39Purine metabolism_Homo sapiens_hsa002301.00421483
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96797973
41Spliceosome_Homo sapiens_hsa030400.95094058
42Sulfur metabolism_Homo sapiens_hsa009200.92960459
43Allograft rejection_Homo sapiens_hsa053300.92909754
44Steroid biosynthesis_Homo sapiens_hsa001000.92571007
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90115049
46Autoimmune thyroid disease_Homo sapiens_hsa053200.88659974
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86465435
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85323844
49Metabolic pathways_Homo sapiens_hsa011000.84215817
50Primary immunodeficiency_Homo sapiens_hsa053400.80968905
51Type I diabetes mellitus_Homo sapiens_hsa049400.80078173
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77862677
53Pyruvate metabolism_Homo sapiens_hsa006200.76816361
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76162056
55Folate biosynthesis_Homo sapiens_hsa007900.74291331
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.70996814
57Nicotine addiction_Homo sapiens_hsa050330.68193062
58Fatty acid elongation_Homo sapiens_hsa000620.66072167
59Graft-versus-host disease_Homo sapiens_hsa053320.66065217
60Collecting duct acid secretion_Homo sapiens_hsa049660.65645210
61Butanoate metabolism_Homo sapiens_hsa006500.65624597
62Non-homologous end-joining_Homo sapiens_hsa034500.64800638
63Tryptophan metabolism_Homo sapiens_hsa003800.64663197
64Chemical carcinogenesis_Homo sapiens_hsa052040.62322637
65Arachidonic acid metabolism_Homo sapiens_hsa005900.62014180
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61317999
67beta-Alanine metabolism_Homo sapiens_hsa004100.53514456
68Caffeine metabolism_Homo sapiens_hsa002320.53287211
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53262858
70Fat digestion and absorption_Homo sapiens_hsa049750.52836957
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49612408
72Selenocompound metabolism_Homo sapiens_hsa004500.46188487
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44955247
74Ether lipid metabolism_Homo sapiens_hsa005650.44927808
75Fatty acid degradation_Homo sapiens_hsa000710.43814944
76Morphine addiction_Homo sapiens_hsa050320.43381234
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43105342
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.42490991
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41089930
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.40596402
81Arginine and proline metabolism_Homo sapiens_hsa003300.39658952
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39513448
83Olfactory transduction_Homo sapiens_hsa047400.39006748
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.35872733
85Basal cell carcinoma_Homo sapiens_hsa052170.35562547
86Retinol metabolism_Homo sapiens_hsa008300.35422517
87Regulation of autophagy_Homo sapiens_hsa041400.35118077
88Glutathione metabolism_Homo sapiens_hsa004800.31774926
89Hedgehog signaling pathway_Homo sapiens_hsa043400.30860342
90Rheumatoid arthritis_Homo sapiens_hsa053230.30399443
91Fatty acid metabolism_Homo sapiens_hsa012120.29405385
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.28585656
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25432053
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23333249
95Ovarian steroidogenesis_Homo sapiens_hsa049130.19436271
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15806870
97p53 signaling pathway_Homo sapiens_hsa041150.15222198
98Fatty acid biosynthesis_Homo sapiens_hsa000610.14530550
99Carbon metabolism_Homo sapiens_hsa012000.12912770
100Taste transduction_Homo sapiens_hsa047420.12386142

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