RPP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.06764986
2DNA deamination (GO:0045006)5.54097806
3purine nucleobase biosynthetic process (GO:0009113)5.39445658
4nucleobase biosynthetic process (GO:0046112)5.18271578
5DNA strand elongation involved in DNA replication (GO:0006271)4.48077739
6ribosome biogenesis (GO:0042254)4.45228645
7formation of translation preinitiation complex (GO:0001731)4.40616754
8maturation of SSU-rRNA (GO:0030490)4.39408767
9ribosomal small subunit assembly (GO:0000028)4.38127268
10DNA replication initiation (GO:0006270)4.37796260
11kynurenine metabolic process (GO:0070189)4.37637811
12telomere maintenance via semi-conservative replication (GO:0032201)4.34203368
13DNA strand elongation (GO:0022616)4.31663254
14L-fucose catabolic process (GO:0042355)4.23647019
15fucose catabolic process (GO:0019317)4.23647019
16L-fucose metabolic process (GO:0042354)4.23647019
17proteasome assembly (GO:0043248)4.19782123
18IMP biosynthetic process (GO:0006188)4.17247686
19DNA replication checkpoint (GO:0000076)4.12489139
20pseudouridine synthesis (GO:0001522)4.12119589
21ribonucleoprotein complex biogenesis (GO:0022613)4.07301898
22spliceosomal snRNP assembly (GO:0000387)4.07131314
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.06355317
24termination of RNA polymerase III transcription (GO:0006386)4.06355317
25indole-containing compound catabolic process (GO:0042436)4.02472432
26indolalkylamine catabolic process (GO:0046218)4.02472432
27tryptophan catabolic process (GO:0006569)4.02472432
28rRNA modification (GO:0000154)3.94952347
29mitotic metaphase plate congression (GO:0007080)3.93507702
30L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.88335424
31indolalkylamine metabolic process (GO:0006586)3.86746816
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81640143
33ribosomal large subunit biogenesis (GO:0042273)3.80926673
34telomere maintenance via recombination (GO:0000722)3.77731014
35IMP metabolic process (GO:0046040)3.76059003
36CENP-A containing nucleosome assembly (GO:0034080)3.73627748
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73574964
38ribosome assembly (GO:0042255)3.72918623
39rRNA processing (GO:0006364)3.71857025
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71353001
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68555396
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68378358
43cellular ketone body metabolic process (GO:0046950)3.63953162
447-methylguanosine mRNA capping (GO:0006370)3.63855186
45viral mRNA export from host cell nucleus (GO:0046784)3.61323894
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.60900423
47rRNA metabolic process (GO:0016072)3.60098318
48RNA capping (GO:0036260)3.59664093
497-methylguanosine RNA capping (GO:0009452)3.59664093
50chromatin remodeling at centromere (GO:0031055)3.59127307
51ribosomal small subunit biogenesis (GO:0042274)3.50737734
52cullin deneddylation (GO:0010388)3.49024147
53translational termination (GO:0006415)3.48756176
54telomere maintenance via telomere lengthening (GO:0010833)3.48646815
55cellular component biogenesis (GO:0044085)3.47952510
56mitotic recombination (GO:0006312)3.46474636
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44275909
58water-soluble vitamin biosynthetic process (GO:0042364)3.44016513
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43678690
60negative regulation of ligase activity (GO:0051352)3.43678690
61protein deneddylation (GO:0000338)3.43316209
62G1/S transition of mitotic cell cycle (GO:0000082)3.42758231
63cell cycle G1/S phase transition (GO:0044843)3.42758231
64tryptophan metabolic process (GO:0006568)3.42316515
65tRNA methylation (GO:0030488)3.42074799
66translational initiation (GO:0006413)3.42063083
67viral transcription (GO:0019083)3.41954817
68transcription-coupled nucleotide-excision repair (GO:0006283)3.40380841
69peptidyl-histidine modification (GO:0018202)3.38200552
70NADH dehydrogenase complex assembly (GO:0010257)3.37973263
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37973263
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.37973263
73regulation of mitochondrial translation (GO:0070129)3.37279938
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36407178
75metaphase plate congression (GO:0051310)3.34710257
76regulation of skeletal muscle contraction (GO:0014819)3.33453204
77translational elongation (GO:0006414)3.32891994
78rRNA methylation (GO:0031167)3.32842832
79L-methionine salvage (GO:0071267)3.32451036
80L-methionine biosynthetic process (GO:0071265)3.32451036
81amino acid salvage (GO:0043102)3.32451036
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32333020
83ketone body metabolic process (GO:1902224)3.29605842
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28905962
85regulation of cellular amino acid metabolic process (GO:0006521)3.28486895
86translation (GO:0006412)3.25894719
87maturation of 5.8S rRNA (GO:0000460)3.24789842
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24334987
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24334987
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23227280
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23227280
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23227280
93DNA damage response, detection of DNA damage (GO:0042769)3.19165132
94transcription from RNA polymerase I promoter (GO:0006360)3.17950549
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17767609
96negative regulation of translation, ncRNA-mediated (GO:0040033)3.17767609
97regulation of translation, ncRNA-mediated (GO:0045974)3.17767609
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.17195915
99positive regulation of ligase activity (GO:0051351)3.16241943
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15723518
101signal transduction involved in DNA damage checkpoint (GO:0072422)3.15723518
102DNA unwinding involved in DNA replication (GO:0006268)3.15439324
103respiratory chain complex IV assembly (GO:0008535)3.15315390
104spliceosomal complex assembly (GO:0000245)3.15082536
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14457540
106DNA replication-independent nucleosome organization (GO:0034724)3.14425932
107DNA replication-independent nucleosome assembly (GO:0006336)3.14425932
108transcription elongation from RNA polymerase I promoter (GO:0006362)3.13900762
109termination of RNA polymerase I transcription (GO:0006363)3.13861766
110regulation of gene silencing by RNA (GO:0060966)3.13807350
111regulation of posttranscriptional gene silencing (GO:0060147)3.13807350
112regulation of gene silencing by miRNA (GO:0060964)3.13807350
113signal transduction involved in cell cycle checkpoint (GO:0072395)3.13231964
114oxidative demethylation (GO:0070989)3.13175434
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12682423
116establishment of chromosome localization (GO:0051303)3.12167954
117protein complex biogenesis (GO:0070271)3.10653206
118protein localization to kinetochore (GO:0034501)3.08447417
119mitotic nuclear envelope disassembly (GO:0007077)3.06768569
120cotranslational protein targeting to membrane (GO:0006613)3.06720211
121* ncRNA processing (GO:0034470)3.04790571
122ubiquinone biosynthetic process (GO:0006744)3.04586663
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04337594
124* ncRNA metabolic process (GO:0034660)3.04104340
125protein targeting to ER (GO:0045047)3.02509956
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01035149
127RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01035149
128folic acid-containing compound biosynthetic process (GO:0009396)3.00721607
129response to pheromone (GO:0019236)3.00039070
130protein K11-linked deubiquitination (GO:0035871)2.97018359
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96505659
132histone exchange (GO:0043486)2.95731937
133mitochondrial respiratory chain complex assembly (GO:0033108)2.94335211
134cellular response to ATP (GO:0071318)2.92732771
135indole-containing compound metabolic process (GO:0042430)2.91879268
136drug catabolic process (GO:0042737)2.90061890
137synaptic transmission, cholinergic (GO:0007271)2.89039955
138sulfation (GO:0051923)2.88719603
139negative regulation of DNA-dependent DNA replication (GO:2000104)2.87091167
140detection of light stimulus involved in sensory perception (GO:0050962)2.86293733
141detection of light stimulus involved in visual perception (GO:0050908)2.86293733
142protein-cofactor linkage (GO:0018065)2.85757979
143ubiquinone metabolic process (GO:0006743)2.83208284
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79720029
145exogenous drug catabolic process (GO:0042738)2.78560570
146cytochrome complex assembly (GO:0017004)2.78396394
147muscle filament sliding (GO:0030049)2.78197903
148actin-myosin filament sliding (GO:0033275)2.78197903
149cornea development in camera-type eye (GO:0061303)2.76281917
150neural tube formation (GO:0001841)2.75252591
151double-strand break repair via homologous recombination (GO:0000724)2.74042086
152recombinational repair (GO:0000725)2.73954889
153negative regulation of telomere maintenance (GO:0032205)2.73295106
154reciprocal meiotic recombination (GO:0007131)2.73040618
155reciprocal DNA recombination (GO:0035825)2.73040618
156regulation of action potential (GO:0098900)2.70777901
157ATP synthesis coupled proton transport (GO:0015986)2.69194096
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69194096
159auditory receptor cell stereocilium organization (GO:0060088)2.66553469
160negative regulation of reactive oxygen species metabolic process (GO:2000378)2.65859188
161aspartate family amino acid catabolic process (GO:0009068)2.65704809
162regulation of hexokinase activity (GO:1903299)2.65028716
163regulation of glucokinase activity (GO:0033131)2.65028716
164neuronal action potential (GO:0019228)2.64404727
165regulation of hippo signaling (GO:0035330)2.63897759
166primary amino compound metabolic process (GO:1901160)2.63895376
167platelet dense granule organization (GO:0060155)2.63649750
168methionine biosynthetic process (GO:0009086)2.61375901
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60505147
170replication fork processing (GO:0031297)2.59915994
171positive regulation of fatty acid oxidation (GO:0046321)2.58845246
172regulation of relaxation of muscle (GO:1901077)2.58679326
173NAD biosynthetic process (GO:0009435)2.57979840
174RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54896802
175rRNA catabolic process (GO:0016075)2.53254146
176protein K6-linked ubiquitination (GO:0085020)2.52969831
177sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51574210
178nonmotile primary cilium assembly (GO:0035058)2.50112115
179DNA demethylation (GO:0080111)2.49866011
180quinone biosynthetic process (GO:1901663)2.48031084
181meiotic chromosome segregation (GO:0045132)2.45943800
182regulation of mitotic spindle checkpoint (GO:1903504)2.45709002
183regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45709002
184fatty acid transmembrane transport (GO:1902001)2.45381432
185protein K63-linked deubiquitination (GO:0070536)2.44920081
186regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44907145
187serotonin metabolic process (GO:0042428)2.44161125
188reflex (GO:0060004)2.43018197
189rhodopsin mediated signaling pathway (GO:0016056)2.41908544
190neuromuscular synaptic transmission (GO:0007274)2.41596962
191membrane depolarization during action potential (GO:0086010)2.41421717
192S-adenosylmethionine metabolic process (GO:0046500)2.41282834
193kidney morphogenesis (GO:0060993)2.41262751
194piRNA metabolic process (GO:0034587)2.39085236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.06985805
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.69049611
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22077864
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07129108
5ZNF274_21170338_ChIP-Seq_K562_Hela3.87019332
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.85936861
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67985109
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.64510315
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.53542092
10VDR_22108803_ChIP-Seq_LS180_Human3.39700582
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.23631582
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14946377
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14661025
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.14167928
15E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10665082
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98692988
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91494691
18EZH2_22144423_ChIP-Seq_EOC_Human2.78196504
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73475712
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69020803
21* VDR_23849224_ChIP-Seq_CD4+_Human2.65033737
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59297801
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53670911
24IGF1R_20145208_ChIP-Seq_DFB_Human2.52584173
25GBX2_23144817_ChIP-Seq_PC3_Human2.52485572
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51722789
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50334766
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49463412
29EWS_26573619_Chip-Seq_HEK293_Human2.43254284
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.41132858
31* XRN2_22483619_ChIP-Seq_HELA_Human2.40181815
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39765887
33FOXM1_23109430_ChIP-Seq_U2OS_Human2.38865826
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38341476
35SALL1_21062744_ChIP-ChIP_HESCs_Human2.36985011
36* FOXP3_21729870_ChIP-Seq_TREG_Human2.32870026
37ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26403645
38DCP1A_22483619_ChIP-Seq_HELA_Human2.24953426
39POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24054566
40* GABP_19822575_ChIP-Seq_HepG2_Human2.21917088
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18372758
42FUS_26573619_Chip-Seq_HEK293_Human2.18135598
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15883087
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04934647
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02653364
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01808684
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00908696
48* SRF_21415370_ChIP-Seq_HL-1_Mouse2.00403356
49ELK1_19687146_ChIP-ChIP_HELA_Human2.00194586
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99544559
51ER_23166858_ChIP-Seq_MCF-7_Human1.98850660
52AR_21909140_ChIP-Seq_LNCAP_Human1.97580662
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96720602
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96597705
55TAF15_26573619_Chip-Seq_HEK293_Human1.96507456
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95272624
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93831738
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93476011
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92838182
60TTF2_22483619_ChIP-Seq_HELA_Human1.91280509
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90720155
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90494251
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.89357174
64P300_19829295_ChIP-Seq_ESCs_Human1.87862951
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87771827
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87210014
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82018827
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74439824
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72980780
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72785163
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.68377233
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.67784606
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67558786
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67193058
75IRF1_19129219_ChIP-ChIP_H3396_Human1.66860965
76CIITA_25753668_ChIP-Seq_RAJI_Human1.66306952
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59764629
78TP53_22573176_ChIP-Seq_HFKS_Human1.58305607
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57608494
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55051585
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53277424
82STAT3_23295773_ChIP-Seq_U87_Human1.51577222
83* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50293466
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50034452
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49243533
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47864352
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47461395
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47172336
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44890743
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44890743
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44703039
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44528510
93TCF4_23295773_ChIP-Seq_U87_Human1.41024768
94* CBP_20019798_ChIP-Seq_JUKART_Human1.40237181
95* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40237181
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39644850
97KDM5A_27292631_Chip-Seq_BREAST_Human1.38924788
98* NANOG_19829295_ChIP-Seq_ESCs_Human1.37123358
99* SOX2_19829295_ChIP-Seq_ESCs_Human1.37123358
100BCAT_22108803_ChIP-Seq_LS180_Human1.37069574
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36431394
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35396587
103AR_21572438_ChIP-Seq_LNCaP_Human1.32601853
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30351908
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30192359
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.29122750
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28587581
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28575817
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.28469383
110* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27438538
111* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27397957
112SMAD4_21799915_ChIP-Seq_A2780_Human1.27277222
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26764605
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26287587
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26176318
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.26122622
117NCOR_22424771_ChIP-Seq_293T_Human1.25658546
118* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23598656
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22589893
120AR_25329375_ChIP-Seq_VCAP_Human1.22519833
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.21468903
122HOXB7_26014856_ChIP-Seq_BT474_Human1.20742436
123REST_21632747_ChIP-Seq_MESCs_Mouse1.19447966
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19223891
125* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18801240
126* FOXA1_25329375_ChIP-Seq_VCAP_Human1.18801240
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18633918
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.18046557
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.17380613
130TCF4_22108803_ChIP-Seq_LS180_Human1.17165654
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16384947
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15798990
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15541593
134MYC_18940864_ChIP-ChIP_HL60_Human1.14575868
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13458764
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13155314
137ELK1_22589737_ChIP-Seq_MCF10A_Human1.12498914
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11744402
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.11386394
140GATA3_21878914_ChIP-Seq_MCF-7_Human1.10974904
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10653671
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10575576
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07745205
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07377483
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07258689
146SMAD3_21741376_ChIP-Seq_EPCs_Human1.07212100
147TFEB_21752829_ChIP-Seq_HELA_Human1.07143412
148GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06155211
149AR_20517297_ChIP-Seq_VCAP_Human1.06023074
150FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04604746
151ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04577538
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04091667
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03929638
154RUNX2_22187159_ChIP-Seq_PCA_Human1.02246420
155MYC_22102868_ChIP-Seq_BL_Human1.01500510
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99839835
157CDX2_22108803_ChIP-Seq_LS180_Human0.99583793
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99170631
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.98459266
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.97522776
161P53_22387025_ChIP-Seq_ESCs_Mouse0.96305289
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96132474
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95456275
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95207206
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95065787
166RNF2_27304074_Chip-Seq_NSC_Mouse0.94522509
167* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94427242
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94163734
169STAT3_18555785_Chip-Seq_ESCs_Mouse0.93469645
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91379357
171STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90957520
172SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88162669
173SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86204690
174* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83615184
175HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81905246
176* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81626570
177SPI1_23547873_ChIP-Seq_NB4_Human0.80907592
178* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80487140
179NANOG_21062744_ChIP-ChIP_HESCs_Human0.78781770
180PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77972279
181HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76790640
182* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76550466
183* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75185650
184HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70831887
185SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69418151
186TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69255925
187NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67186202
188TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.65216069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.49712707
2MP0004957_abnormal_blastocyst_morpholog4.44880687
3MP0010094_abnormal_chromosome_stability4.44864109
4MP0003111_abnormal_nucleus_morphology4.33309824
5MP0008058_abnormal_DNA_repair4.03638002
6MP0003077_abnormal_cell_cycle4.02681444
7MP0004145_abnormal_muscle_electrophysio3.99014224
8MP0008057_abnormal_DNA_replication3.80761285
9MP0008007_abnormal_cellular_replicative3.47887123
10MP0002396_abnormal_hematopoietic_system2.84352080
11MP0002837_dystrophic_cardiac_calcinosis2.83774821
12MP0008932_abnormal_embryonic_tissue2.70999587
13MP0003195_calcinosis2.59667665
14MP0000566_synostosis2.50541850
15MP0006036_abnormal_mitochondrial_physio2.35997551
16MP0004043_abnormal_pH_regulation2.30667527
17MP0003806_abnormal_nucleotide_metabolis2.27871202
18MP0000569_abnormal_digit_pigmentation2.25477991
19MP0003123_paternal_imprinting2.19039255
20MP0004130_abnormal_muscle_cell2.11031579
21MP0003718_maternal_effect2.07197817
22MP0003186_abnormal_redox_activity2.05893724
23MP0005551_abnormal_eye_electrophysiolog2.05657027
24MP0009379_abnormal_foot_pigmentation2.04704808
25MP0003786_premature_aging2.04293696
26MP0000350_abnormal_cell_proliferation1.98888650
27MP0001730_embryonic_growth_arrest1.97036803
28MP0002876_abnormal_thyroid_physiology1.96809460
29MP0004142_abnormal_muscle_tone1.93421921
30MP0009697_abnormal_copulation1.92557308
31MP0008877_abnormal_DNA_methylation1.83540829
32MP0000490_abnormal_crypts_of1.79364628
33MP0009046_muscle_twitch1.74848772
34MP0005670_abnormal_white_adipose1.73631155
35MP0010030_abnormal_orbit_morphology1.72525493
36MP0008872_abnormal_physiological_respon1.70417801
37MP0002132_abnormal_respiratory_system1.68863302
38MP0000427_abnormal_hair_cycle1.65418996
39MP0009745_abnormal_behavioral_response1.62369753
40MP0006035_abnormal_mitochondrial_morpho1.61808014
41MP0005174_abnormal_tail_pigmentation1.58464326
42MP0001968_abnormal_touch/_nociception1.57722170
43MP0001986_abnormal_taste_sensitivity1.53032841
44MP0003890_abnormal_embryonic-extraembry1.51733762
45MP0006292_abnormal_olfactory_placode1.50227784
46MP0008875_abnormal_xenobiotic_pharmacok1.49972961
47MP0004147_increased_porphyrin_level1.49341522
48MP0003787_abnormal_imprinting1.43954796
49MP0005645_abnormal_hypothalamus_physiol1.43180550
50MP0001501_abnormal_sleep_pattern1.42443491
51MP0005253_abnormal_eye_physiology1.40196916
52MP0000372_irregular_coat_pigmentation1.40099471
53MP0006072_abnormal_retinal_apoptosis1.38915843
54MP0004133_heterotaxia1.38786535
55MP0003567_abnormal_fetal_cardiomyocyte1.36916431
56MP0002080_prenatal_lethality1.35248753
57MP0002272_abnormal_nervous_system1.34448319
58MP0002019_abnormal_tumor_incidence1.33950977
59MP0004808_abnormal_hematopoietic_stem1.31325828
60MP0001485_abnormal_pinna_reflex1.31148031
61MP0001697_abnormal_embryo_size1.30913220
62MP0004036_abnormal_muscle_relaxation1.30563600
63MP0004084_abnormal_cardiac_muscle1.28502614
64MP0005380_embryogenesis_phenotype1.28332099
65MP0001672_abnormal_embryogenesis/_devel1.28332099
66MP0008775_abnormal_heart_ventricle1.27844421
67MP0000313_abnormal_cell_death1.26358353
68MP0002160_abnormal_reproductive_system1.25553774
69MP0002736_abnormal_nociception_after1.24805882
70MP0002106_abnormal_muscle_physiology1.22499113
71MP0003221_abnormal_cardiomyocyte_apopto1.21932600
72MP0005085_abnormal_gallbladder_physiolo1.20718147
73MP0006054_spinal_hemorrhage1.19331889
74MP0000631_abnormal_neuroendocrine_gland1.18418160
75MP0005620_abnormal_muscle_contractility1.17855869
76MP0001545_abnormal_hematopoietic_system1.17281563
77MP0005397_hematopoietic_system_phenotyp1.17281563
78MP0003984_embryonic_growth_retardation1.16835196
79MP0004885_abnormal_endolymph1.16242681
80MP0006276_abnormal_autonomic_nervous1.15194775
81MP0002210_abnormal_sex_determination1.13402550
82MP0000358_abnormal_cell_content/1.12666360
83MP0002088_abnormal_embryonic_growth/wei1.11107602
84MP0003763_abnormal_thymus_physiology1.10796452
85MP0009333_abnormal_splenocyte_physiolog1.09377372
86MP0008260_abnormal_autophagy1.07796294
87MP0002064_seizures1.07257991
88MP0010307_abnormal_tumor_latency1.06197420
89MP0002089_abnormal_postnatal_growth/wei1.05263392
90MP0005386_behavior/neurological_phenoty1.03745088
91MP0004924_abnormal_behavior1.03745088
92MP0001529_abnormal_vocalization1.02109865
93MP0003137_abnormal_impulse_conducting1.01960094
94MP0002138_abnormal_hepatobiliary_system1.01370531
95MP0005332_abnormal_amino_acid1.00831218
96MP0005369_muscle_phenotype1.00139872
97MP0003252_abnormal_bile_duct1.00130058
98MP0002102_abnormal_ear_morphology0.99553836
99MP0003646_muscle_fatigue0.98533140
100MP0003656_abnormal_erythrocyte_physiolo0.97037449
101MP0003136_yellow_coat_color0.96543746
102MP0002067_abnormal_sensory_capabilities0.96323318
103MP0001764_abnormal_homeostasis0.95357947
104MP0005646_abnormal_pituitary_gland0.95096160
105MP0003011_delayed_dark_adaptation0.95094467
106MP0000230_abnormal_systemic_arterial0.94373869
107MP0004484_altered_response_of0.94125978
108MP0005451_abnormal_body_composition0.94042501
109MP0000015_abnormal_ear_pigmentation0.93372532
110MP0004742_abnormal_vestibular_system0.93278696
111MP0002332_abnormal_exercise_endurance0.93218019
112MP0005084_abnormal_gallbladder_morpholo0.93185505
113MP0002557_abnormal_social/conspecific_i0.92631673
114MP0001188_hyperpigmentation0.92185443
115MP0001145_abnormal_male_reproductive0.92123410
116MP0005075_abnormal_melanosome_morpholog0.92119641
117MP0005389_reproductive_system_phenotype0.92036278
118MP0002234_abnormal_pharynx_morphology0.91865309
119MP0002572_abnormal_emotion/affect_behav0.90741927
120MP0002085_abnormal_embryonic_tissue0.90393610
121MP0004085_abnormal_heartbeat0.90346725
122MP0003315_abnormal_perineum_morphology0.90313850
123MP0008961_abnormal_basal_metabolism0.89167002
124MP0001324_abnormal_eye_pigmentation0.86723396
125MP0000653_abnormal_sex_gland0.82562716
126MP0005083_abnormal_biliary_tract0.82149507
127MP0002938_white_spotting0.82004443
128MP0005409_darkened_coat_color0.81941265
129MP0002086_abnormal_extraembryonic_tissu0.81740353
130MP0001486_abnormal_startle_reflex0.81513731
131MP0005195_abnormal_posterior_eye0.80521057
132MP0004215_abnormal_myocardial_fiber0.80022720
133MP0001919_abnormal_reproductive_system0.79901059
134MP0002722_abnormal_immune_system0.79170128
135MP0000689_abnormal_spleen_morphology0.78174036
136MP0002733_abnormal_thermal_nociception0.78049819
137MP0005266_abnormal_metabolism0.77944748
138MP0003950_abnormal_plasma_membrane0.77716677
139MP0001929_abnormal_gametogenesis0.77665875
140MP0001119_abnormal_female_reproductive0.76754907
141MP0002735_abnormal_chemical_nociception0.76721620
142MP0002398_abnormal_bone_marrow0.75836569
143MP0003937_abnormal_limbs/digits/tail_de0.75740746
144MP0002752_abnormal_somatic_nervous0.75077456
145MP0000703_abnormal_thymus_morphology0.74586861
146MP0001440_abnormal_grooming_behavior0.73438824
147MP0002095_abnormal_skin_pigmentation0.72606311
148MP0005423_abnormal_somatic_nervous0.72337403
149MP0001970_abnormal_pain_threshold0.72237186
150MP0005187_abnormal_penis_morphology0.72152617
151MP0001542_abnormal_bone_strength0.71698555
152MP0010386_abnormal_urinary_bladder0.70905776
153MP0002653_abnormal_ependyma_morphology0.70874290
154MP0000383_abnormal_hair_follicle0.70853243
155MP0002928_abnormal_bile_duct0.70746708
156MP0002084_abnormal_developmental_patter0.70423826
157MP0010352_gastrointestinal_tract_polyps0.68758126
158MP0003121_genomic_imprinting0.68655146
159MP0008789_abnormal_olfactory_epithelium0.68460009
160MP0005384_cellular_phenotype0.67631636
161MP0000465_gastrointestinal_hemorrhage0.66273050
162MP0004197_abnormal_fetal_growth/weight/0.64942225
163MP0001293_anophthalmia0.64820114
164MP0002009_preneoplasia0.62528337
165MP0009672_abnormal_birth_weight0.61693093
166MP0002751_abnormal_autonomic_nervous0.60561631
167MP0000749_muscle_degeneration0.59884886
168MP0002429_abnormal_blood_cell0.59137059
169MP0002638_abnormal_pupillary_reflex0.54713044
170MP0002269_muscular_atrophy0.54425621
171MP0000750_abnormal_muscle_regeneration0.53892262
172MP0000049_abnormal_middle_ear0.53738212
173MP0005621_abnormal_cell_physiology0.51950472

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.88801431
2Aplastic anemia (HP:0001915)4.06722366
3Abnormal number of erythroid precursors (HP:0012131)4.04372929
4Abnormality of cells of the erythroid lineage (HP:0012130)4.03869004
5Congenital stationary night blindness (HP:0007642)4.03411159
6Oral leukoplakia (HP:0002745)3.82043258
7Abnormality of midbrain morphology (HP:0002418)3.71378456
8Molar tooth sign on MRI (HP:0002419)3.71378456
9Breast hypoplasia (HP:0003187)3.67868032
10Muscle fiber inclusion bodies (HP:0100299)3.67380177
11Degeneration of anterior horn cells (HP:0002398)3.63336279
12Abnormality of the anterior horn cell (HP:0006802)3.63336279
13Nemaline bodies (HP:0003798)3.58780084
14Hepatocellular necrosis (HP:0001404)3.54132138
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.49890046
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.49890046
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.46711408
18Cerebral hypomyelination (HP:0006808)3.43533238
19Acute necrotizing encephalopathy (HP:0006965)3.43467151
20Hepatic necrosis (HP:0002605)3.36390378
21Abnormal mitochondria in muscle tissue (HP:0008316)3.33407894
22Muscle hypertrophy of the lower extremities (HP:0008968)3.32063967
23Progressive muscle weakness (HP:0003323)3.28110200
24Microretrognathia (HP:0000308)3.26290809
25Hyperalaninemia (HP:0003348)3.25135544
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.25135544
27Abnormality of alanine metabolism (HP:0010916)3.25135544
28Increased serum lactate (HP:0002151)3.24602040
29Nephronophthisis (HP:0000090)3.23804018
30Microvesicular hepatic steatosis (HP:0001414)3.21631916
31Reticulocytopenia (HP:0001896)3.20730379
32Increased CSF lactate (HP:0002490)3.18183554
33Mitochondrial inheritance (HP:0001427)3.13755083
34Calf muscle hypertrophy (HP:0008981)3.12269248
35Type II lissencephaly (HP:0007260)3.09924643
36Increased serum pyruvate (HP:0003542)3.07665604
37Abnormality of glycolysis (HP:0004366)3.07665604
383-Methylglutaconic aciduria (HP:0003535)3.03054366
39Abnormality of the renal cortex (HP:0011035)3.02809755
40Carpal bone hypoplasia (HP:0001498)3.01921175
41Colon cancer (HP:0003003)3.00888554
42True hermaphroditism (HP:0010459)2.98161501
43Hyperventilation (HP:0002883)2.86820263
44Patellar aplasia (HP:0006443)2.82274629
45Acute encephalopathy (HP:0006846)2.80172220
46Abnormality of the renal medulla (HP:0100957)2.74165386
47Lactic acidosis (HP:0003128)2.68578066
48Inability to walk (HP:0002540)2.67671919
49Type 2 muscle fiber atrophy (HP:0003554)2.66424031
50Attenuation of retinal blood vessels (HP:0007843)2.66179804
51Type I transferrin isoform profile (HP:0003642)2.65100607
52Aplasia/Hypoplasia of the patella (HP:0006498)2.64460804
53Exercise intolerance (HP:0003546)2.64157749
54Rough bone trabeculation (HP:0100670)2.63801694
55Progressive macrocephaly (HP:0004481)2.59060103
56Selective tooth agenesis (HP:0001592)2.58663084
57Genetic anticipation (HP:0003743)2.58045418
58Progressive inability to walk (HP:0002505)2.55653010
59Macrocytic anemia (HP:0001972)2.52350313
60Sparse eyelashes (HP:0000653)2.50883420
61Tubular atrophy (HP:0000092)2.50448850
62Secondary amenorrhea (HP:0000869)2.49544916
63Medulloblastoma (HP:0002885)2.49514741
64Abnormality of the preputium (HP:0100587)2.47998218
65Pendular nystagmus (HP:0012043)2.43775786
66Muscle fiber atrophy (HP:0100295)2.41845100
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40931845
68Clumsiness (HP:0002312)2.40549896
69Meckel diverticulum (HP:0002245)2.37833599
70Shoulder girdle muscle weakness (HP:0003547)2.35909592
71Respiratory difficulties (HP:0002880)2.35833128
72Large for gestational age (HP:0001520)2.35824408
73Broad-based gait (HP:0002136)2.35778546
74Agnosia (HP:0010524)2.35286810
75CNS demyelination (HP:0007305)2.34892897
76Chronic hepatic failure (HP:0100626)2.34739757
77Abnormality of the ileum (HP:0001549)2.33310727
78Pallor (HP:0000980)2.32339179
7911 pairs of ribs (HP:0000878)2.29803989
80Medial flaring of the eyebrow (HP:0010747)2.28899038
81Gaze-evoked nystagmus (HP:0000640)2.27967122
82Myelodysplasia (HP:0002863)2.27855669
83Pancytopenia (HP:0001876)2.26127734
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.25528296
85CNS hypomyelination (HP:0003429)2.24721221
86Multiple enchondromatosis (HP:0005701)2.24045660
87Premature ovarian failure (HP:0008209)2.22342616
88Postnatal microcephaly (HP:0005484)2.22242010
89Thrombocytosis (HP:0001894)2.21591082
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.20976594
91Abnormal drinking behavior (HP:0030082)2.20491766
92Polydipsia (HP:0001959)2.20491766
93Respiratory failure (HP:0002878)2.20254603
94Abnormal spermatogenesis (HP:0008669)2.19779450
95Abolished electroretinogram (ERG) (HP:0000550)2.19705887
96Abnormality of the pons (HP:0007361)2.19150486
97Entropion (HP:0000621)2.18688625
98Megaloblastic anemia (HP:0001889)2.18107833
99Slender long bone (HP:0003100)2.17565052
100Lissencephaly (HP:0001339)2.17460083
101Cerebral edema (HP:0002181)2.16083322
102Abnormality of chromosome stability (HP:0003220)2.15533464
103Cerebellar dysplasia (HP:0007033)2.15418410
104Renal cortical cysts (HP:0000803)2.15351968
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.15255349
106Increased hepatocellular lipid droplets (HP:0006565)2.14161986
107Exercise-induced muscle cramps (HP:0003710)2.12980728
108Protruding tongue (HP:0010808)2.12699648
109Hypoplasia of the pons (HP:0012110)2.12052420
110Poor head control (HP:0002421)2.09937067
111Chorioretinal atrophy (HP:0000533)2.09399796
112Fair hair (HP:0002286)2.09083904
113Decreased circulating renin level (HP:0003351)2.07692870
114Progressive cerebellar ataxia (HP:0002073)2.07452212
115Pancreatic cysts (HP:0001737)2.06415242
116Unsteady gait (HP:0002317)2.05744476
117Hyperglycinuria (HP:0003108)2.03855758
118Bone marrow hypocellularity (HP:0005528)2.03580424
119Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02536534
120Ragged-red muscle fibers (HP:0003200)2.01007398
121Areflexia of lower limbs (HP:0002522)2.00871099
122Sloping forehead (HP:0000340)1.98987835
123Lipid accumulation in hepatocytes (HP:0006561)1.98557267
124Optic nerve coloboma (HP:0000588)1.98477199
125Sclerocornea (HP:0000647)1.98060801
126Reduced antithrombin III activity (HP:0001976)1.96995523
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.94596508
128Cystic liver disease (HP:0006706)1.94055814
129Pancreatic fibrosis (HP:0100732)1.93045573
130Decreased central vision (HP:0007663)1.91609009
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91472541
132Abnormal protein N-linked glycosylation (HP:0012347)1.91472541
133Abnormal protein glycosylation (HP:0012346)1.91472541
134Abnormal glycosylation (HP:0012345)1.91472541
135Ketosis (HP:0001946)1.91239890
136Febrile seizures (HP:0002373)1.91084826
137Ketoacidosis (HP:0001993)1.89456669
138Abnormal lung lobation (HP:0002101)1.89453802
139Anencephaly (HP:0002323)1.88419167
140Abnormal rod and cone electroretinograms (HP:0008323)1.88381054
141Chromsome breakage (HP:0040012)1.87950631
142Duodenal stenosis (HP:0100867)1.87586680
143Small intestinal stenosis (HP:0012848)1.87586680
144Broad alveolar ridges (HP:0000187)1.87206195
145Severe muscular hypotonia (HP:0006829)1.86376987
146Pelvic girdle muscle weakness (HP:0003749)1.84765550
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.84684326
148Absent thumb (HP:0009777)1.84131714
149Concave nail (HP:0001598)1.83992565
150Methylmalonic aciduria (HP:0012120)1.83592960
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83313360
152Emotional lability (HP:0000712)1.83256754
153Absent phalangeal crease (HP:0006109)1.82264032
154IgM deficiency (HP:0002850)1.82091108
155Optic disc pallor (HP:0000543)1.80898522
156Furrowed tongue (HP:0000221)1.80452173
157Increased corneal curvature (HP:0100692)1.79912153
158Keratoconus (HP:0000563)1.79912153
159Abnormal biliary tract physiology (HP:0012439)1.79586852
160Bile duct proliferation (HP:0001408)1.79586852
161Optic nerve hypoplasia (HP:0000609)1.78811703
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78746643
163Gait imbalance (HP:0002141)1.78349042
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77578165
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76348034
166Stomach cancer (HP:0012126)1.76055805
167Congenital sensorineural hearing impairment (HP:0008527)1.75429002
168Distal arthrogryposis (HP:0005684)1.74829767
169Confusion (HP:0001289)1.74769334
170Partial agenesis of the corpus callosum (HP:0001338)1.74697500
171Methylmalonic acidemia (HP:0002912)1.74509183
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.73455647
173Type 1 muscle fiber predominance (HP:0003803)1.71507284
174Polyuria (HP:0000103)1.69974096
175Abnormal finger flexion creases (HP:0006143)1.69093585
176Pachygyria (HP:0001302)1.67861027
177Congenital hepatic fibrosis (HP:0002612)1.67725308
178Congenital, generalized hypertrichosis (HP:0004540)1.67324007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.51628550
2BUB15.24509866
3MKNK24.64090633
4OBSCN4.19686504
5WEE14.03773452
6MKNK13.72454903
7EIF2AK13.66557942
8STK163.28934208
9TSSK63.08787254
10ADRBK22.95313165
11EIF2AK32.70475871
12PHKG22.58169233
13PHKG12.58169233
14TNIK2.54013138
15SRPK12.40874465
16NME22.32170923
17BRSK22.29803242
18CDC72.29228421
19GRK12.26343107
20WNK42.16794805
21ACVR1B2.14583419
22NEK12.05649442
23NUAK12.02587592
24TAOK31.94095381
25WNK31.93716525
26VRK11.80643518
27PLK41.73767289
28CDK81.69986534
29CASK1.60159605
30INSRR1.59542732
31OXSR11.53851408
32MAPK131.53791620
33BCKDK1.49980017
34CCNB11.49598883
35NEK21.47139096
36PLK11.45861140
37MAP4K21.43143112
38DYRK31.39381913
39STK391.36901367
40PLK31.34915380
41STK38L1.33136533
42PIM21.30258972
43RPS6KB21.29058930
44DAPK21.23640190
45BRSK11.21887927
46ZAK1.20188277
47TTK1.16914419
48AURKB1.15623318
49TAOK21.13677812
50SCYL21.11661840
51PASK1.08922979
52ADRBK11.07884106
53MARK11.07709664
54CDK191.05541667
55CDK71.03513505
56ATR1.03150910
57MAP2K31.02809097
58MAP3K41.02610810
59PDK31.01823284
60PDK41.01823284
61TLK11.01207931
62TGFBR11.00938463
63PAK31.00703720
64PIK3CG1.00269340
65MAP3K120.98243032
66RPS6KA40.98004794
67MAPKAPK30.93154028
68AURKA0.92113907
69TESK20.90812311
70CHEK20.87109095
71TIE10.84457939
72MAP2K60.82888158
73NME10.82634987
74EEF2K0.80990548
75STK30.79990788
76FLT30.78775395
77MST40.77640511
78TAF10.75728938
79PIK3CA0.73580616
80TRIM280.72462441
81CAMK1D0.72013684
82MAP3K80.71775310
83BRAF0.69744210
84AKT30.69719073
85PRKCE0.64162021
86CAMK10.64113503
87TRPM70.63886438
88NLK0.63217408
89CSNK2A10.61706815
90CSNK2A20.61497857
91CDK40.60952379
92PKN10.60857184
93CAMK2A0.59272722
94STK110.58838357
95TXK0.58124666
96CHEK10.58107518
97EIF2AK20.57706300
98PRKAA10.57681673
99MAP3K50.56394527
100SGK20.56017457
101PRKAA20.55076933
102PAK40.53790910
103EPHA20.53286930
104RPS6KA50.53111760
105MUSK0.51267376
106KDR0.51100606
107MAP3K110.49340134
108MAP2K70.49184062
109TEC0.48809322
110PRKACA0.48802724
111CAMK1G0.48080984
112DYRK20.47575478
113CAMK40.47312561
114PNCK0.47225433
115IKBKB0.46656655
116CAMKK20.46492449
117NTRK30.45531609
118RPS6KA60.44334985
119PINK10.44244436
120ERBB30.43808057
121PRKCQ0.43330014
122LIMK10.43194788
123DAPK10.42922258
124RPS6KB10.42329450
125ATM0.42292797
126PTK2B0.40157673
127MAPK120.40144859
128PRKG10.39962098
129CSNK1A10.39440502
130WNK10.38645695
131PAK10.37496819
132MAP3K70.37163459
133STK240.36277531
134PRKCI0.36262544
135CDK20.34970035
136CHUK0.33844281
137YES10.33390837
138MAPKAPK50.33171835
139MAP3K60.32596937
140PRKCG0.32182023
141RAF10.31551115
142CDK10.31160761
143MELK0.30512525
144CSNK1D0.30413026
145STK100.29517964
146PIM10.28732397
147PDK20.28718579
148PRKACB0.28576783
149IRAK30.27562311
150ILK0.27094558
151BTK0.25462320
152KIT0.25235891
153TESK10.24342983
154PLK20.23838751
155ABL20.22348000
156NEK90.22040768
157ZAP700.21686519
158BMPR1B0.20828646
159JAK30.19457986
160MAPK110.18437972
161MAP2K40.17314051

Predicted pathways (KEGG)

RankGene SetZ-score
1RIG-I-like receptor signaling pathway_Homo sapiens_hsa046227.01028947
2DNA replication_Homo sapiens_hsa030304.61742448
3Proteasome_Homo sapiens_hsa030504.13638265
4RNA polymerase_Homo sapiens_hsa030204.13197837
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.00675514
6Mismatch repair_Homo sapiens_hsa034303.87013485
7Ribosome_Homo sapiens_hsa030103.65956220
8Spliceosome_Homo sapiens_hsa030403.12353634
9* RNA transport_Homo sapiens_hsa030133.02744808
10Pyrimidine metabolism_Homo sapiens_hsa002402.88970153
11Nucleotide excision repair_Homo sapiens_hsa034202.78746326
12Homologous recombination_Homo sapiens_hsa034402.70754368
13Base excision repair_Homo sapiens_hsa034102.66802847
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59795075
15Nitrogen metabolism_Homo sapiens_hsa009102.52518488
16Linoleic acid metabolism_Homo sapiens_hsa005912.46627571
17Phototransduction_Homo sapiens_hsa047442.39956354
18Cell cycle_Homo sapiens_hsa041102.30911412
19Tryptophan metabolism_Homo sapiens_hsa003802.22275870
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14894569
21One carbon pool by folate_Homo sapiens_hsa006702.03889040
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03456372
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00277939
24RNA degradation_Homo sapiens_hsa030181.99480585
25Caffeine metabolism_Homo sapiens_hsa002321.97789300
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94933681
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93830375
28Basal transcription factors_Homo sapiens_hsa030221.86030490
29Fanconi anemia pathway_Homo sapiens_hsa034601.77496163
30Purine metabolism_Homo sapiens_hsa002301.73666292
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71974368
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59967652
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57584147
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.54248914
35Nicotine addiction_Homo sapiens_hsa050331.48348161
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44793032
37Protein export_Homo sapiens_hsa030601.41011980
38Ether lipid metabolism_Homo sapiens_hsa005651.39661267
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37335153
40Non-homologous end-joining_Homo sapiens_hsa034501.35489755
41p53 signaling pathway_Homo sapiens_hsa041151.30819804
42Parkinsons disease_Homo sapiens_hsa050121.30727380
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29815471
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.24899183
45Folate biosynthesis_Homo sapiens_hsa007901.23592391
46Biosynthesis of amino acids_Homo sapiens_hsa012301.23185478
47Oxidative phosphorylation_Homo sapiens_hsa001901.22808514
48Sulfur metabolism_Homo sapiens_hsa009201.19037249
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17639921
50Pentose phosphate pathway_Homo sapiens_hsa000301.16561755
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.16064082
52Huntingtons disease_Homo sapiens_hsa050161.15971011
53mRNA surveillance pathway_Homo sapiens_hsa030151.14361159
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.13371901
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08700456
56Epstein-Barr virus infection_Homo sapiens_hsa051691.08629592
57Vitamin B6 metabolism_Homo sapiens_hsa007501.07514549
58Taste transduction_Homo sapiens_hsa047421.06783952
59Chemical carcinogenesis_Homo sapiens_hsa052041.03666006
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.02951604
61Sulfur relay system_Homo sapiens_hsa041221.01370337
62Retinol metabolism_Homo sapiens_hsa008301.01268637
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00823030
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00820413
65Carbon metabolism_Homo sapiens_hsa012000.97273165
66Calcium signaling pathway_Homo sapiens_hsa040200.96134953
67Fatty acid degradation_Homo sapiens_hsa000710.94903165
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94722084
69Histidine metabolism_Homo sapiens_hsa003400.91662321
70Morphine addiction_Homo sapiens_hsa050320.88265924
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.87531368
72ABC transporters_Homo sapiens_hsa020100.86770037
73Olfactory transduction_Homo sapiens_hsa047400.86224566
74Selenocompound metabolism_Homo sapiens_hsa004500.85799396
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81313645
76Oocyte meiosis_Homo sapiens_hsa041140.80014144
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.79557235
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77533815
79Serotonergic synapse_Homo sapiens_hsa047260.76154891
80Fat digestion and absorption_Homo sapiens_hsa049750.74981380
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74681785
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73555741
83Thyroid cancer_Homo sapiens_hsa052160.70514154
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70203243
85Ovarian steroidogenesis_Homo sapiens_hsa049130.69556769
86Vitamin digestion and absorption_Homo sapiens_hsa049770.66735872
87Glycerolipid metabolism_Homo sapiens_hsa005610.66649635
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66522201
89Insulin secretion_Homo sapiens_hsa049110.65851794
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65284100
91Circadian entrainment_Homo sapiens_hsa047130.64160997
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64007428
93Lysine degradation_Homo sapiens_hsa003100.61765649
94Glutathione metabolism_Homo sapiens_hsa004800.60634848
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59905842
96Regulation of autophagy_Homo sapiens_hsa041400.59653493
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58476655
98Glutamatergic synapse_Homo sapiens_hsa047240.58327140
99Metabolic pathways_Homo sapiens_hsa011000.57187015
100Fructose and mannose metabolism_Homo sapiens_hsa000510.56346630
101Alzheimers disease_Homo sapiens_hsa050100.56218574
102N-Glycan biosynthesis_Homo sapiens_hsa005100.54963429
103Oxytocin signaling pathway_Homo sapiens_hsa049210.53413245
104Galactose metabolism_Homo sapiens_hsa000520.53148839
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52398891
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52043150
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51930194
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49499137
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48838147
110Herpes simplex infection_Homo sapiens_hsa051680.48394909
111Pyruvate metabolism_Homo sapiens_hsa006200.47495482
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.47275367
113GABAergic synapse_Homo sapiens_hsa047270.46176185
114Mineral absorption_Homo sapiens_hsa049780.46159822
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45783510
116Systemic lupus erythematosus_Homo sapiens_hsa053220.45773629
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41632389
118Antigen processing and presentation_Homo sapiens_hsa046120.41628028
119Legionellosis_Homo sapiens_hsa051340.39906004
120Dilated cardiomyopathy_Homo sapiens_hsa054140.39353260
121Fatty acid metabolism_Homo sapiens_hsa012120.39316107
122Arginine biosynthesis_Homo sapiens_hsa002200.37125534
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36578436
124Arginine and proline metabolism_Homo sapiens_hsa003300.35563430
125Propanoate metabolism_Homo sapiens_hsa006400.33300296
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30697435
127Viral carcinogenesis_Homo sapiens_hsa052030.28940172
128HTLV-I infection_Homo sapiens_hsa051660.24014537
129HIF-1 signaling pathway_Homo sapiens_hsa040660.23203964
130beta-Alanine metabolism_Homo sapiens_hsa004100.20728273
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19203784
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18017193
133Arachidonic acid metabolism_Homo sapiens_hsa005900.11868121
134Peroxisome_Homo sapiens_hsa041460.05491467
135Renin-angiotensin system_Homo sapiens_hsa046140.05400824
136Cardiac muscle contraction_Homo sapiens_hsa042600.03766545
137Shigellosis_Homo sapiens_hsa051310.03013644
138Alcoholism_Homo sapiens_hsa050340.02690290
139Circadian rhythm_Homo sapiens_hsa047100.01659658
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.00920060
141Melanoma_Homo sapiens_hsa052180.00818265
142Apoptosis_Homo sapiens_hsa042100.00166045
143TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0372502
144Hepatitis B_Homo sapiens_hsa05161-0.0329755
145Colorectal cancer_Homo sapiens_hsa05210-0.0315955
146NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0282638
147Butanoate metabolism_Homo sapiens_hsa00650-0.0261909
148Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0222236
149Bladder cancer_Homo sapiens_hsa05219-0.0202027
150Influenza A_Homo sapiens_hsa05164-0.0183790
151Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0139917
152Measles_Homo sapiens_hsa05162-0.0125116
153Type I diabetes mellitus_Homo sapiens_hsa04940-0.0049799

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