RPL7P32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.11056611
2cytidine deamination (GO:0009972)4.54854079
3cytidine metabolic process (GO:0046087)4.54854079
4cytidine catabolic process (GO:0006216)4.54854079
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.47348246
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.42470891
7ATP synthesis coupled proton transport (GO:0015986)4.38990018
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38990018
9ribosomal small subunit assembly (GO:0000028)4.34386267
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92747493
11pyrimidine ribonucleoside catabolic process (GO:0046133)3.89414682
12ribosomal large subunit biogenesis (GO:0042273)3.62146434
13protein neddylation (GO:0045116)3.55029562
14respiratory electron transport chain (GO:0022904)3.52730117
15electron transport chain (GO:0022900)3.52123375
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41231673
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39528343
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34201328
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34201328
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26582094
21platelet dense granule organization (GO:0060155)3.22790161
22viral transcription (GO:0019083)3.20260134
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17795780
24translational termination (GO:0006415)3.15024454
25kynurenine metabolic process (GO:0070189)3.14067162
26indole-containing compound catabolic process (GO:0042436)3.11143277
27indolalkylamine catabolic process (GO:0046218)3.11143277
28tryptophan catabolic process (GO:0006569)3.11143277
29protein complex biogenesis (GO:0070271)3.09887784
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09850541
31axoneme assembly (GO:0035082)3.09656654
32water-soluble vitamin biosynthetic process (GO:0042364)3.09036088
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.06619656
34termination of RNA polymerase III transcription (GO:0006386)3.06619656
35cotranslational protein targeting to membrane (GO:0006613)3.04732524
36mannosylation (GO:0097502)3.02115933
37protein targeting to ER (GO:0045047)3.01256704
38maturation of SSU-rRNA (GO:0030490)2.96336381
39positive T cell selection (GO:0043368)2.95848909
40regulation of regulatory T cell differentiation (GO:0045589)2.95668330
41translational elongation (GO:0006414)2.94571284
42positive thymic T cell selection (GO:0045059)2.94056586
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90436282
44protein localization to endoplasmic reticulum (GO:0070972)2.88147087
45L-fucose catabolic process (GO:0042355)2.87130749
46fucose catabolic process (GO:0019317)2.87130749
47L-fucose metabolic process (GO:0042354)2.87130749
48establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84788658
49regulation of cellular amino acid metabolic process (GO:0006521)2.84692075
50proteasome assembly (GO:0043248)2.82897164
51preassembly of GPI anchor in ER membrane (GO:0016254)2.79374865
52mitochondrial respiratory chain complex assembly (GO:0033108)2.77644889
53tryptophan metabolic process (GO:0006568)2.77057327
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.75023523
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73126535
56establishment of protein localization to mitochondrial membrane (GO:0090151)2.72291153
57mast cell activation (GO:0045576)2.72288086
58negative regulation of T cell differentiation in thymus (GO:0033085)2.71270867
59S-adenosylmethionine metabolic process (GO:0046500)2.69067421
60regulation of isotype switching to IgG isotypes (GO:0048302)2.67319048
61behavioral response to nicotine (GO:0035095)2.66806402
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65089450
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.65089450
64NADH dehydrogenase complex assembly (GO:0010257)2.65089450
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64816368
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64816368
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64816368
68regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.64512230
69positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63687778
70negative regulation of T cell apoptotic process (GO:0070233)2.63564598
71hydrogen ion transmembrane transport (GO:1902600)2.63062013
72GPI anchor metabolic process (GO:0006505)2.61902145
73response to interferon-beta (GO:0035456)2.61631652
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61438970
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61438970
76immunoglobulin mediated immune response (GO:0016064)2.58633330
77proton transport (GO:0015992)2.57831004
78rRNA modification (GO:0000154)2.57511376
79positive regulation of prostaglandin secretion (GO:0032308)2.56769299
80negative regulation of mast cell activation (GO:0033004)2.56596173
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55541201
82indolalkylamine metabolic process (GO:0006586)2.54697921
83piRNA metabolic process (GO:0034587)2.54052630
84hydrogen transport (GO:0006818)2.53376727
85response to pheromone (GO:0019236)2.53088979
86translation (GO:0006412)2.53058227
87GPI anchor biosynthetic process (GO:0006506)2.52494912
88purine deoxyribonucleotide catabolic process (GO:0009155)2.52009212
89positive regulation of alpha-beta T cell proliferation (GO:0046641)2.49228867
90cytochrome complex assembly (GO:0017004)2.47717998
91ATP biosynthetic process (GO:0006754)2.47278444
92negative regulation of heart rate (GO:0010459)2.46703084
93actin nucleation (GO:0045010)2.46317551
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.46043256
95regulation of interleukin-8 secretion (GO:2000482)2.45797642
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.45704674
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45704674
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44499973
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.44329049
100regulation of chronic inflammatory response (GO:0002676)2.42181452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.31029578
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25513649
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.08344325
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.92689834
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91404208
6VDR_22108803_ChIP-Seq_LS180_Human2.87976306
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78747897
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75596525
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.70947829
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54361672
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.52198417
12IGF1R_20145208_ChIP-Seq_DFB_Human2.43501023
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42631435
14VDR_23849224_ChIP-Seq_CD4+_Human2.26015271
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23149954
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17151035
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98292847
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97132142
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92640642
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89194816
21EWS_26573619_Chip-Seq_HEK293_Human1.86042446
22ELK1_19687146_ChIP-ChIP_HELA_Human1.85358851
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.84525444
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83562456
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.73039325
26FOXP3_21729870_ChIP-Seq_TREG_Human1.66324894
27MYC_18940864_ChIP-ChIP_HL60_Human1.63119921
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61824715
29TP53_22573176_ChIP-Seq_HFKS_Human1.61718396
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58664527
31GATA3_26560356_Chip-Seq_TH2_Human1.57600333
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56713048
33AR_20517297_ChIP-Seq_VCAP_Human1.55882215
34ER_23166858_ChIP-Seq_MCF-7_Human1.55713342
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.54313781
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.54313781
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48178079
38FUS_26573619_Chip-Seq_HEK293_Human1.47387686
39EZH2_22144423_ChIP-Seq_EOC_Human1.45495017
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.44791756
41NANOG_19829295_ChIP-Seq_ESCs_Human1.43793186
42SOX2_19829295_ChIP-Seq_ESCs_Human1.43793186
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43594823
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41976200
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41790876
46CBP_20019798_ChIP-Seq_JUKART_Human1.41756575
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41756575
48P300_19829295_ChIP-Seq_ESCs_Human1.40783006
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36068196
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35483747
51TAF15_26573619_Chip-Seq_HEK293_Human1.35384040
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33357175
53MYB_26560356_Chip-Seq_TH2_Human1.31963230
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30439122
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.30156995
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.30156503
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28518971
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27722146
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26763168
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26731729
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26268720
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25263106
63NCOR_22424771_ChIP-Seq_293T_Human1.24276303
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22885383
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.22734625
66BCAT_22108803_ChIP-Seq_LS180_Human1.18095231
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17757568
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16237414
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.16235644
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13878754
71GBX2_23144817_ChIP-Seq_PC3_Human1.12344878
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11478945
73TAF2_19829295_ChIP-Seq_ESCs_Human1.10145374
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09982124
75NANOG_20526341_ChIP-Seq_ESCs_Human1.08332965
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08318732
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07337303
78GATA3_27048872_Chip-Seq_THYMUS_Human1.07263578
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.06954630
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06474239
81ERG_20517297_ChIP-Seq_VCAP_Human1.06463228
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05238395
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04397586
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04254436
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03604688
86TCF4_22108803_ChIP-Seq_LS180_Human1.02628880
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00284171
88RBPJ_21746931_ChIP-Seq_IB4_Human1.00204795
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99716512
90HOXB7_26014856_ChIP-Seq_BT474_Human0.99574804
91MYC_19829295_ChIP-Seq_ESCs_Human0.99358434
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.98635399
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98574708
94RUNX_20019798_ChIP-Seq_JUKART_Human0.97738765
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97392331
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97147776
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96944559
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94823544
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.94035027
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.92944775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.22268254
2MP0001835_abnormal_antigen_presentation3.55445279
3MP0002138_abnormal_hepatobiliary_system3.06467992
4MP0009379_abnormal_foot_pigmentation2.29521366
5MP0004147_increased_porphyrin_level2.24031049
6MP0009785_altered_susceptibility_to2.22450274
7MP0008877_abnormal_DNA_methylation2.18774730
8MP0003646_muscle_fatigue2.17980364
9MP0008875_abnormal_xenobiotic_pharmacok2.08487244
10MP0003806_abnormal_nucleotide_metabolis2.06767866
11MP0002837_dystrophic_cardiac_calcinosis2.05380615
12MP0008872_abnormal_physiological_respon2.03940227
13MP0006072_abnormal_retinal_apoptosis2.03851194
14MP0002166_altered_tumor_susceptibility1.95314881
15MP0001800_abnormal_humoral_immune1.90675666
16MP0003195_calcinosis1.89315068
17MP0003763_abnormal_thymus_physiology1.89071811
18MP0005645_abnormal_hypothalamus_physiol1.88785040
19MP0005551_abnormal_eye_electrophysiolog1.88283050
20MP0002148_abnormal_hypersensitivity_rea1.87041958
21MP0005000_abnormal_immune_tolerance1.77203095
22MP0001968_abnormal_touch/_nociception1.76932277
23MP0000685_abnormal_immune_system1.73398529
24MP0005646_abnormal_pituitary_gland1.70025264
25MP0005075_abnormal_melanosome_morpholog1.68759119
26MP0000372_irregular_coat_pigmentation1.68733845
27MP0009333_abnormal_splenocyte_physiolog1.68356278
28MP0006292_abnormal_olfactory_placode1.64670217
29MP0002006_tumorigenesis1.64184996
30MP0002102_abnormal_ear_morphology1.57744885
31MP0002723_abnormal_immune_serum1.54047986
32MP0002736_abnormal_nociception_after1.51775931
33MP0001873_stomach_inflammation1.51761161
34MP0004145_abnormal_muscle_electrophysio1.51727085
35MP0002876_abnormal_thyroid_physiology1.46697493
36MP0003866_abnormal_defecation1.43897096
37MP0002420_abnormal_adaptive_immunity1.43671305
38MP0005387_immune_system_phenotype1.42587340
39MP0001790_abnormal_immune_system1.42587340
40MP0001819_abnormal_immune_cell1.42291033
41MP0005253_abnormal_eye_physiology1.41336583
42MP0005389_reproductive_system_phenotype1.38274354
43MP0002452_abnormal_antigen_presenting1.38090699
44MP0004142_abnormal_muscle_tone1.38079875
45MP0005084_abnormal_gallbladder_morpholo1.36957529
46MP0009764_decreased_sensitivity_to1.32897584
47MP0001986_abnormal_taste_sensitivity1.31287329
48MP0005377_hearing/vestibular/ear_phenot1.31089148
49MP0003878_abnormal_ear_physiology1.31089148
50MP0004885_abnormal_endolymph1.30215685
51MP0005025_abnormal_response_to1.28421762
52MP0001905_abnormal_dopamine_level1.24242976
53MP0005410_abnormal_fertilization1.20579042
54MP0002160_abnormal_reproductive_system1.18480552
55MP0003011_delayed_dark_adaptation1.17591541
56MP0001501_abnormal_sleep_pattern1.16665510
57MP0001919_abnormal_reproductive_system1.15754807
58MP0003786_premature_aging1.13968575
59MP0006036_abnormal_mitochondrial_physio1.12829682
60MP0002277_abnormal_respiratory_mucosa1.12342956
61MP0008995_early_reproductive_senescence1.09169293
62MP0006082_CNS_inflammation1.08961867
63MP0010155_abnormal_intestine_physiology1.07485955
64MP0010386_abnormal_urinary_bladder1.07082596
65MP0001764_abnormal_homeostasis1.06732382
66MP0000716_abnormal_immune_system1.06730714
67MP0003724_increased_susceptibility_to1.04504482
68MP0001845_abnormal_inflammatory_respons1.03344289
69MP0005085_abnormal_gallbladder_physiolo1.01847922
70MP0002405_respiratory_system_inflammati1.01779871
71MP0003252_abnormal_bile_duct1.00903046
72MP0002638_abnormal_pupillary_reflex1.00745276
73MP0002398_abnormal_bone_marrow0.99946164
74MP0006276_abnormal_autonomic_nervous0.99149760
75MP0005636_abnormal_mineral_homeostasis0.98030275
76MP0002163_abnormal_gland_morphology0.96735520
77MP0001485_abnormal_pinna_reflex0.95781528
78MP0002693_abnormal_pancreas_physiology0.93479733
79MP0009697_abnormal_copulation0.93304620
80MP0000689_abnormal_spleen_morphology0.93065045
81MP0003718_maternal_effect0.91714515
82MP0001765_abnormal_ion_homeostasis0.89251027
83MP0002272_abnormal_nervous_system0.87702967
84MP0008469_abnormal_protein_level0.86173396
85MP0009046_muscle_twitch0.83951235
86MP0002095_abnormal_skin_pigmentation0.82981999
87MP0003787_abnormal_imprinting0.82890560
88MP0002234_abnormal_pharynx_morphology0.81597893
89MP0009643_abnormal_urine_homeostasis0.80844453
90MP0001970_abnormal_pain_threshold0.80231001
91MP0000631_abnormal_neuroendocrine_gland0.79431228
92MP0009745_abnormal_behavioral_response0.79386169
93MP0002429_abnormal_blood_cell0.78234488
94MP0003186_abnormal_redox_activity0.76535246
95MP0002733_abnormal_thermal_nociception0.75479925
96MP0003880_abnormal_central_pattern0.74587612
97MP0005332_abnormal_amino_acid0.73960388
98MP0005174_abnormal_tail_pigmentation0.72610092
99MP0000230_abnormal_systemic_arterial0.72493606
100MP0001440_abnormal_grooming_behavior0.71352761

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.19217943
2Acute necrotizing encephalopathy (HP:0006965)3.81595204
3Mitochondrial inheritance (HP:0001427)3.72562432
4Congenital stationary night blindness (HP:0007642)3.69294718
5Pancreatic cysts (HP:0001737)3.58940089
6Abnormal rod and cone electroretinograms (HP:0008323)3.49381191
7IgG deficiency (HP:0004315)3.40120089
8Molar tooth sign on MRI (HP:0002419)3.38032844
9Abnormality of midbrain morphology (HP:0002418)3.38032844
10Increased CSF lactate (HP:0002490)3.36757396
11Aplastic anemia (HP:0001915)3.32205792
12Abnormal mitochondria in muscle tissue (HP:0008316)3.32173686
13Progressive macrocephaly (HP:0004481)3.31557045
143-Methylglutaconic aciduria (HP:0003535)3.31108139
15Acute encephalopathy (HP:0006846)3.31025746
16Hepatocellular necrosis (HP:0001404)3.27857189
17Congenital, generalized hypertrichosis (HP:0004540)3.20770117
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.11057035
19Absent/shortened dynein arms (HP:0200106)3.11057035
20Pancreatic fibrosis (HP:0100732)3.08160686
21Increased hepatocellular lipid droplets (HP:0006565)3.07289034
22Hypoproteinemia (HP:0003075)3.05337267
23Hepatic necrosis (HP:0002605)3.03636233
24Abolished electroretinogram (ERG) (HP:0000550)3.02677067
25Elevated erythrocyte sedimentation rate (HP:0003565)3.00178552
26Abnormality of B cell number (HP:0010975)2.99283361
27True hermaphroditism (HP:0010459)2.91338094
28Lipid accumulation in hepatocytes (HP:0006561)2.90754306
29Attenuation of retinal blood vessels (HP:0007843)2.89428055
30Severe combined immunodeficiency (HP:0004430)2.77760406
31Nephronophthisis (HP:0000090)2.74529761
32Thyroiditis (HP:0100646)2.69183605
33Stomatitis (HP:0010280)2.66876395
34Abnormality of the prostate (HP:0008775)2.61391365
35Cerebral edema (HP:0002181)2.53106400
36Decreased central vision (HP:0007663)2.53043115
37B lymphocytopenia (HP:0010976)2.51999813
38Renal Fanconi syndrome (HP:0001994)2.51468964
39Autoimmune hemolytic anemia (HP:0001890)2.47188862
40Increased intramyocellular lipid droplets (HP:0012240)2.45594707
41Abnormality of the renal cortex (HP:0011035)2.45528722
42Optic disc pallor (HP:0000543)2.43146105
43Abnormality of T cell number (HP:0011839)2.41445886
44Abnormal biliary tract physiology (HP:0012439)2.41032705
45Bile duct proliferation (HP:0001408)2.41032705
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37709594
47Abnormal respiratory motile cilium morphology (HP:0005938)2.36084951
48Abnormal respiratory epithelium morphology (HP:0012253)2.36084951
49T lymphocytopenia (HP:0005403)2.35806013
50Abnormality of the renal medulla (HP:0100957)2.33961274
51Constricted visual fields (HP:0001133)2.30539777
52Abnormal ciliary motility (HP:0012262)2.27499726
53Methylmalonic acidemia (HP:0002912)2.26409567
54Pendular nystagmus (HP:0012043)2.26182052
55Increased serum lactate (HP:0002151)2.19404525
56Renal cortical cysts (HP:0000803)2.18819418
57Abnormal respiratory motile cilium physiology (HP:0012261)2.17974987
58Abnormality of T cells (HP:0002843)2.15873374
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15419618
60Asplenia (HP:0001746)2.14152679
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.12879803
62Exertional dyspnea (HP:0002875)2.09362820
63Increased muscle lipid content (HP:0009058)2.07735088
64Cystic liver disease (HP:0006706)2.07254956
65Increased IgM level (HP:0003496)2.07217519
66Reticulocytopenia (HP:0001896)2.04254746
67Lactic acidosis (HP:0003128)2.02495581
68Combined immunodeficiency (HP:0005387)2.01343900
69Chronic sinusitis (HP:0011109)2.01297795
70Polydipsia (HP:0001959)2.00373326
71Abnormal drinking behavior (HP:0030082)2.00373326
72Type 2 muscle fiber atrophy (HP:0003554)1.99481207
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98363670
74Lethargy (HP:0001254)1.98219093
75Abnormality of cells of the erythroid lineage (HP:0012130)1.97954084
76Pancytopenia (HP:0001876)1.97699013
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97137863
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97137863
79Chronic hepatic failure (HP:0100626)1.95284006
80Panhypogammaglobulinemia (HP:0003139)1.95059594
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94890047
82Abnormality of eosinophils (HP:0001879)1.93524658
83Keratoconus (HP:0000563)1.91828007
84Increased corneal curvature (HP:0100692)1.91828007
85Type II lissencephaly (HP:0007260)1.90096993
86Glycosuria (HP:0003076)1.88109250
87Abnormality of urine glucose concentration (HP:0011016)1.88109250
88Aplasia/hypoplasia of the uterus (HP:0008684)1.87816725
89Respiratory failure (HP:0002878)1.87546245
90Chronic diarrhea (HP:0002028)1.87333782
91Sclerocornea (HP:0000647)1.84057694
92Abnormal number of erythroid precursors (HP:0012131)1.83605366
93Hypothermia (HP:0002045)1.80596567
94Methylmalonic aciduria (HP:0012120)1.79499468
95Male pseudohermaphroditism (HP:0000037)1.79115172
96Medial flaring of the eyebrow (HP:0010747)1.78391018
97Abnormality of T cell physiology (HP:0011840)1.77939048
98Autoimmune thrombocytopenia (HP:0001973)1.76772247
99Supernumerary spleens (HP:0009799)1.74523728
100Recurrent bronchitis (HP:0002837)1.73364709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.88010880
2FRK3.42165155
3MAP4K22.94372618
4GRK12.69193031
5NUAK12.68265134
6KDR2.64906427
7CDK192.64076090
8ADRBK22.54502332
9ZAK2.53359144
10BCKDK2.41568181
11TAOK32.40075711
12TLK12.34099587
13VRK21.98749746
14TIE11.92811187
15MAP4K11.82742459
16ITK1.74742593
17MST41.71377049
18TEC1.68306118
19BMPR1B1.65802403
20STK161.65722783
21EIF2AK31.65364574
22MAP3K121.60939761
23KIT1.58046855
24TESK21.56777347
25FES1.45791435
26PINK11.41689794
27VRK11.36644445
28SYK1.34326742
29WNK41.27525770
30PASK1.27517011
31MUSK1.25782009
32OXSR11.25273425
33SCYL21.18956359
34BMPR21.16481228
35NME11.15979171
36IKBKB1.12261632
37INSRR1.05567140
38MYLK1.03096537
39BTK1.01661465
40WNK30.99145904
41PRKCQ0.94432155
42CSF1R0.91181263
43LYN0.90054377
44DAPK10.85539916
45GRK60.81823550
46DYRK20.81542337
47BUB10.79715685
48LCK0.79050468
49MAP2K60.78581703
50RPS6KA50.77121816
51DAPK20.76978128
52MAPKAPK30.76483279
53ERBB30.74204022
54FLT30.74111997
55ACVR1B0.73430984
56PHKG20.72588294
57PHKG10.72588294
58PLK20.70517733
59GRK70.70371625
60CSNK1G30.69276952
61PIK3CG0.68350392
62ADRBK10.67748302
63IKBKE0.66954268
64TRIM280.65825678
65TNK20.64543227
66OBSCN0.62317954
67STK390.59350885
68CDK80.59112909
69PIK3CA0.57454762
70JAK30.56706539
71IGF1R0.55310174
72TRPM70.54429679
73TGFBR10.54015188
74PRKCE0.53355316
75PLK30.53103574
76LIMK10.53012477
77CSNK1G20.52141183
78CSNK1G10.51681931
79CSNK1A1L0.49285503
80MAPK130.47513322
81RPS6KA40.47185779
82MKNK10.45477296
83DAPK30.45386274
84CAMKK20.44795175
85PRKCA0.44593887
86PRKACA0.42857449
87EIF2AK20.41586783
88MAPKAPK50.41425547
89CSK0.38801561
90SRPK10.37611275
91PLK40.35224133
92CSNK2A10.34983902
93CSNK2A20.33194173
94ABL10.32495173
95MATK0.31830693
96ILK0.31801746
97ATR0.30407462
98PIM10.30265422
99CSNK1A10.30001326
100PTK2B0.29858371

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.86818117
2Allograft rejection_Homo sapiens_hsa053303.41836631
3Proteasome_Homo sapiens_hsa030503.36748377
4Autoimmune thyroid disease_Homo sapiens_hsa053203.25015252
5Graft-versus-host disease_Homo sapiens_hsa053323.14875363
6Oxidative phosphorylation_Homo sapiens_hsa001903.10862140
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.03550153
8Ribosome_Homo sapiens_hsa030102.87341639
9Type I diabetes mellitus_Homo sapiens_hsa049402.86805157
10Primary immunodeficiency_Homo sapiens_hsa053402.76929377
11Parkinsons disease_Homo sapiens_hsa050122.44252619
12Protein export_Homo sapiens_hsa030602.23804461
13Antigen processing and presentation_Homo sapiens_hsa046122.18881106
14RNA polymerase_Homo sapiens_hsa030202.09959023
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85363739
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75855347
17Linoleic acid metabolism_Homo sapiens_hsa005911.71001197
18Phototransduction_Homo sapiens_hsa047441.69731013
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68854025
20Rheumatoid arthritis_Homo sapiens_hsa053231.62790422
21Alzheimers disease_Homo sapiens_hsa050101.60999254
22Huntingtons disease_Homo sapiens_hsa050161.56724300
23Caffeine metabolism_Homo sapiens_hsa002321.45752924
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43122020
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39880342
26Hematopoietic cell lineage_Homo sapiens_hsa046401.37025551
27Homologous recombination_Homo sapiens_hsa034401.34751316
28Cardiac muscle contraction_Homo sapiens_hsa042601.31002020
29Viral myocarditis_Homo sapiens_hsa054161.27206590
30RNA degradation_Homo sapiens_hsa030181.25589583
31Nitrogen metabolism_Homo sapiens_hsa009101.22287563
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18259471
33Staphylococcus aureus infection_Homo sapiens_hsa051501.16298395
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12089474
35One carbon pool by folate_Homo sapiens_hsa006701.06231559
36Propanoate metabolism_Homo sapiens_hsa006401.03413337
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.02294830
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97038731
39Chemical carcinogenesis_Homo sapiens_hsa052040.95520167
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93052464
41Arachidonic acid metabolism_Homo sapiens_hsa005900.91104843
42Sulfur metabolism_Homo sapiens_hsa009200.90102659
43Systemic lupus erythematosus_Homo sapiens_hsa053220.89982295
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88241389
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87137862
46Tryptophan metabolism_Homo sapiens_hsa003800.87020817
47Pyrimidine metabolism_Homo sapiens_hsa002400.85462724
48Retinol metabolism_Homo sapiens_hsa008300.84599966
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83977099
50Basal transcription factors_Homo sapiens_hsa030220.83486221
51Butanoate metabolism_Homo sapiens_hsa006500.83122231
52Purine metabolism_Homo sapiens_hsa002300.82665488
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81306801
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.80305638
55Olfactory transduction_Homo sapiens_hsa047400.78000042
56Peroxisome_Homo sapiens_hsa041460.76969636
57Ether lipid metabolism_Homo sapiens_hsa005650.75624869
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71776080
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71570119
60Fanconi anemia pathway_Homo sapiens_hsa034600.71193957
61Leishmaniasis_Homo sapiens_hsa051400.70536357
62Fat digestion and absorption_Homo sapiens_hsa049750.70230821
63Regulation of autophagy_Homo sapiens_hsa041400.68437696
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65855366
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65036495
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61637695
67T cell receptor signaling pathway_Homo sapiens_hsa046600.59469989
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.59463137
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58982723
70Nucleotide excision repair_Homo sapiens_hsa034200.56651649
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54161654
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53643635
73Taste transduction_Homo sapiens_hsa047420.52904989
74RNA transport_Homo sapiens_hsa030130.51852498
75Collecting duct acid secretion_Homo sapiens_hsa049660.51844384
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.48714926
77Mismatch repair_Homo sapiens_hsa034300.47834269
78Metabolic pathways_Homo sapiens_hsa011000.47319242
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.44345813
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43456593
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41322351
82Spliceosome_Homo sapiens_hsa030400.41108106
83Herpes simplex infection_Homo sapiens_hsa051680.38357631
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.34682412
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32002711
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31459929
87Nicotine addiction_Homo sapiens_hsa050330.29138362
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28269005
89DNA replication_Homo sapiens_hsa030300.25553331
90Fatty acid degradation_Homo sapiens_hsa000710.25328738
91Salivary secretion_Homo sapiens_hsa049700.24479140
92Base excision repair_Homo sapiens_hsa034100.24411933
93beta-Alanine metabolism_Homo sapiens_hsa004100.23784264
94Selenocompound metabolism_Homo sapiens_hsa004500.23655642
95Glutathione metabolism_Homo sapiens_hsa004800.23248795
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22733203
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20994203
98Epstein-Barr virus infection_Homo sapiens_hsa051690.20781396
99Morphine addiction_Homo sapiens_hsa050320.20532856
100Pancreatic secretion_Homo sapiens_hsa049720.19840272

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