RPL7AP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.97491441
2maturation of SSU-rRNA (GO:0030490)6.34568232
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.17217449
4viral transcription (GO:0019083)5.93011551
5translational termination (GO:0006415)5.73909413
6ATP synthesis coupled proton transport (GO:0015986)5.53746310
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53746310
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.31646356
9cotranslational protein targeting to membrane (GO:0006613)5.24772064
10protein targeting to ER (GO:0045047)5.22726140
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.04557661
12response to pheromone (GO:0019236)5.00792956
13translational elongation (GO:0006414)5.00759754
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98762583
15protein localization to endoplasmic reticulum (GO:0070972)4.92805176
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.74173939
17respiratory electron transport chain (GO:0022904)4.61718349
18electron transport chain (GO:0022900)4.59652328
19protein neddylation (GO:0045116)4.59422370
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.51551353
21ribosomal small subunit biogenesis (GO:0042274)4.50095660
22viral life cycle (GO:0019058)4.46156975
23sequestering of actin monomers (GO:0042989)4.42855513
24protein complex biogenesis (GO:0070271)4.41160081
25DNA deamination (GO:0045006)4.35963440
26cellular protein complex disassembly (GO:0043624)4.33712225
27cytidine metabolic process (GO:0046087)4.25883777
28cytidine catabolic process (GO:0006216)4.25883777
29cytidine deamination (GO:0009972)4.25883777
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.18552003
31platelet dense granule organization (GO:0060155)4.14571969
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.12360747
33mitochondrial respiratory chain complex I assembly (GO:0032981)4.12360747
34NADH dehydrogenase complex assembly (GO:0010257)4.12360747
35translational initiation (GO:0006413)4.05929745
36mitochondrial respiratory chain complex assembly (GO:0033108)4.05252246
37GPI anchor metabolic process (GO:0006505)3.82133433
38GPI anchor biosynthetic process (GO:0006506)3.67086633
39translation (GO:0006412)3.60974025
40rRNA modification (GO:0000154)3.56754561
41protein complex disassembly (GO:0043241)3.53714789
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53458378
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53458378
44mannosylation (GO:0097502)3.53177212
45ATP biosynthetic process (GO:0006754)3.49257806
46macromolecular complex disassembly (GO:0032984)3.44973559
47pyrimidine ribonucleoside catabolic process (GO:0046133)3.44475721
48negative regulation by host of viral transcription (GO:0043922)3.40263237
49protein targeting to membrane (GO:0006612)3.39212972
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35408799
51preassembly of GPI anchor in ER membrane (GO:0016254)3.32313714
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20057505
53ribosomal large subunit biogenesis (GO:0042273)3.17626579
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.16541701
55cellular component biogenesis (GO:0044085)3.14774411
56nuclear-transcribed mRNA catabolic process (GO:0000956)3.08808708
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07514296
58proteasome assembly (GO:0043248)3.04878041
59hydrogen ion transmembrane transport (GO:1902600)3.04588964
60regulation of cellular amino acid metabolic process (GO:0006521)3.00166062
61rRNA methylation (GO:0031167)2.97829869
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97616701
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97419562
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95489575
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.90942551
66mRNA catabolic process (GO:0006402)2.88657868
67chaperone-mediated protein transport (GO:0072321)2.87952411
68inner mitochondrial membrane organization (GO:0007007)2.87852681
69cullin deneddylation (GO:0010388)2.85471344
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85434898
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85434898
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85434898
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83761727
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83761727
75water-soluble vitamin biosynthetic process (GO:0042364)2.82568164
76ribonucleoprotein complex biogenesis (GO:0022613)2.81866556
77deoxyribose phosphate catabolic process (GO:0046386)2.81175903
78proton transport (GO:0015992)2.80826378
79iron-sulfur cluster assembly (GO:0016226)2.80254720
80metallo-sulfur cluster assembly (GO:0031163)2.80254720
81ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79471312
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.77686971
83termination of RNA polymerase III transcription (GO:0006386)2.77686971
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76448266
85hydrogen transport (GO:0006818)2.75492238
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.75182938
87cellular ketone body metabolic process (GO:0046950)2.74495827
88respiratory chain complex IV assembly (GO:0008535)2.71256090
89ketone body metabolic process (GO:1902224)2.69544867
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.67407742
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67380998
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.67380998
93nucleoside triphosphate biosynthetic process (GO:0009142)2.66513566
94oxidative phosphorylation (GO:0006119)2.66325782
95actin nucleation (GO:0045010)2.65572341
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64761935
97deoxyribonucleotide catabolic process (GO:0009264)2.60782749
98negative regulation of ligase activity (GO:0051352)2.57581001
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57581001
100regulation of activation of Janus kinase activity (GO:0010533)2.56568035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.25346990
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.25769929
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79749042
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61643340
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.41655990
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24823251
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19663012
8ZNF274_21170338_ChIP-Seq_K562_Hela3.03905582
9VDR_22108803_ChIP-Seq_LS180_Human2.69474602
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60773459
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.51940302
12VDR_23849224_ChIP-Seq_CD4+_Human2.40518526
13ELK1_19687146_ChIP-ChIP_HELA_Human2.35166870
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18885967
15IGF1R_20145208_ChIP-Seq_DFB_Human2.12479592
16MYC_18940864_ChIP-ChIP_HL60_Human2.10590275
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08250249
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.02608064
19FOXP3_21729870_ChIP-Seq_TREG_Human1.95977384
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92838423
21FUS_26573619_Chip-Seq_HEK293_Human1.89120986
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84277900
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.81046284
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75252430
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64034071
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.63457590
27EWS_26573619_Chip-Seq_HEK293_Human1.61450115
28TP53_22573176_ChIP-Seq_HFKS_Human1.57216398
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51184061
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42877643
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.41816583
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38368001
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36871848
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36077805
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35735719
36P300_19829295_ChIP-Seq_ESCs_Human1.34431716
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.34376626
38AR_20517297_ChIP-Seq_VCAP_Human1.31468326
39ER_23166858_ChIP-Seq_MCF-7_Human1.31157204
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31066536
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28815011
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27399635
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.26809781
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26809781
45TAF15_26573619_Chip-Seq_HEK293_Human1.26182159
46GABP_19822575_ChIP-Seq_HepG2_Human1.25692985
47TTF2_22483619_ChIP-Seq_HELA_Human1.23157682
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22847089
49CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21774980
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21740981
51ERG_20517297_ChIP-Seq_VCAP_Human1.20083002
52SOX2_19829295_ChIP-Seq_ESCs_Human1.17692644
53NANOG_19829295_ChIP-Seq_ESCs_Human1.17692644
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17277958
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17127087
56HTT_18923047_ChIP-ChIP_STHdh_Human1.12608571
57DCP1A_22483619_ChIP-Seq_HELA_Human1.12119785
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11902475
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10449934
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10357531
61NCOR_22424771_ChIP-Seq_293T_Human1.10133610
62NANOG_20526341_ChIP-Seq_ESCs_Human1.08597028
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07825254
64XRN2_22483619_ChIP-Seq_HELA_Human1.07677864
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.07614187
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07064087
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07003924
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05177048
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04627599
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.04606199
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02981235
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01388100
73GATA3_26560356_Chip-Seq_TH2_Human1.01276777
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01185268
75MYC_19829295_ChIP-Seq_ESCs_Human1.00563348
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00517926
77IRF1_19129219_ChIP-ChIP_H3396_Human1.00379924
78PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98214735
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97561554
80CBP_20019798_ChIP-Seq_JUKART_Human0.97561554
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97235802
82EZH2_22144423_ChIP-Seq_EOC_Human0.97065947
83PHF8_20622853_ChIP-Seq_HELA_Human0.96439987
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96173038
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96150788
86BCAT_22108803_ChIP-Seq_LS180_Human0.95809389
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.95536786
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95458496
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95201587
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95193595
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95044872
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.94921918
93E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94912123
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94789016
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94700431
96TCF4_22108803_ChIP-Seq_LS180_Human0.93537925
97RNF2_27304074_Chip-Seq_NSC_Mouse0.92080391
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91406114
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91129259
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90092813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.29475922
2MP0006292_abnormal_olfactory_placode3.64196760
3MP0000372_irregular_coat_pigmentation3.05095188
4MP0002102_abnormal_ear_morphology2.84293272
5MP0005671_abnormal_response_to2.80155506
6MP0003880_abnormal_central_pattern2.67136293
7MP0008877_abnormal_DNA_methylation2.45400979
8MP0004147_increased_porphyrin_level2.44581683
9MP0003136_yellow_coat_color2.08480726
10MP0005075_abnormal_melanosome_morpholog2.07469668
11MP0003646_muscle_fatigue2.05311783
12MP0002277_abnormal_respiratory_mucosa2.00182650
13MP0004142_abnormal_muscle_tone1.84940342
14MP0006276_abnormal_autonomic_nervous1.84645367
15MP0003122_maternal_imprinting1.83979764
16MP0001986_abnormal_taste_sensitivity1.77358564
17MP0002095_abnormal_skin_pigmentation1.71524089
18MP0004145_abnormal_muscle_electrophysio1.70659574
19MP0002234_abnormal_pharynx_morphology1.70181803
20MP0005551_abnormal_eye_electrophysiolog1.68898423
21MP0005253_abnormal_eye_physiology1.67635356
22MP0001764_abnormal_homeostasis1.64897253
23MP0003693_abnormal_embryo_hatching1.62816317
24MP0002132_abnormal_respiratory_system1.60297985
25MP0006072_abnormal_retinal_apoptosis1.59508096
26MP0002163_abnormal_gland_morphology1.59040438
27MP0008875_abnormal_xenobiotic_pharmacok1.56914379
28MP0002938_white_spotting1.56799363
29MP0002837_dystrophic_cardiac_calcinosis1.54702470
30MP0008872_abnormal_physiological_respon1.53891836
31MP0003787_abnormal_imprinting1.50640276
32MP0001485_abnormal_pinna_reflex1.50581277
33MP0000631_abnormal_neuroendocrine_gland1.49965921
34MP0003186_abnormal_redox_activity1.46512194
35MP0005084_abnormal_gallbladder_morpholo1.46104968
36MP0005645_abnormal_hypothalamus_physiol1.41337616
37MP0002876_abnormal_thyroid_physiology1.39183375
38MP0008995_early_reproductive_senescence1.38924109
39MP0003878_abnormal_ear_physiology1.36459334
40MP0005377_hearing/vestibular/ear_phenot1.36459334
41MP0001905_abnormal_dopamine_level1.35811443
42MP0004885_abnormal_endolymph1.34684920
43MP0003786_premature_aging1.31859462
44MP0005379_endocrine/exocrine_gland_phen1.30001778
45MP0008058_abnormal_DNA_repair1.29120408
46MP0000049_abnormal_middle_ear1.28594988
47MP0004134_abnormal_chest_morphology1.28230784
48MP0002638_abnormal_pupillary_reflex1.28196227
49MP0001293_anophthalmia1.26351786
50MP0005410_abnormal_fertilization1.20306283
51MP0002736_abnormal_nociception_after1.19365718
52MP0006036_abnormal_mitochondrial_physio1.17858371
53MP0003011_delayed_dark_adaptation1.15240719
54MP0009333_abnormal_splenocyte_physiolog1.12822823
55MP0002160_abnormal_reproductive_system1.12371196
56MP0006035_abnormal_mitochondrial_morpho1.10998369
57MP0003806_abnormal_nucleotide_metabolis1.09741632
58MP0005389_reproductive_system_phenotype1.02930863
59MP0001963_abnormal_hearing_physiology1.01534986
60MP0003718_maternal_effect1.01496051
61MP0003121_genomic_imprinting1.00967057
62MP0009697_abnormal_copulation1.00430083
63MP0005670_abnormal_white_adipose0.99302515
64MP0005646_abnormal_pituitary_gland0.99137880
65MP0002148_abnormal_hypersensitivity_rea0.95881570
66MP0005085_abnormal_gallbladder_physiolo0.92823717
67MP0002090_abnormal_vision0.92140675
68MP0009785_altered_susceptibility_to0.91800263
69MP0000026_abnormal_inner_ear0.91265962
70MP0002138_abnormal_hepatobiliary_system0.90769253
71MP0001119_abnormal_female_reproductive0.89603270
72MP0004043_abnormal_pH_regulation0.89311707
73MP0001661_extended_life_span0.89100287
74MP0001324_abnormal_eye_pigmentation0.88875075
75MP0002653_abnormal_ependyma_morphology0.88062304
76MP0000647_abnormal_sebaceous_gland0.85250260
77MP0005174_abnormal_tail_pigmentation0.84448095
78MP0005408_hypopigmentation0.83933847
79MP0004742_abnormal_vestibular_system0.82640479
80MP0008789_abnormal_olfactory_epithelium0.82425040
81MP0001929_abnormal_gametogenesis0.80284339
82MP0003195_calcinosis0.80135198
83MP0005195_abnormal_posterior_eye0.76981092
84MP0001968_abnormal_touch/_nociception0.75798429
85MP0003698_abnormal_male_reproductive0.75696188
86MP0001529_abnormal_vocalization0.74988504
87MP0003567_abnormal_fetal_cardiomyocyte0.73961193
88MP0003938_abnormal_ear_development0.72083566
89MP0002210_abnormal_sex_determination0.70523620
90MP0005391_vision/eye_phenotype0.70257398
91MP0002752_abnormal_somatic_nervous0.69852444
92MP0005332_abnormal_amino_acid0.68194145
93MP0003763_abnormal_thymus_physiology0.67452060
94MP0006082_CNS_inflammation0.67032728
95MP0002751_abnormal_autonomic_nervous0.66912676
96MP0001984_abnormal_olfaction0.66093814
97MP0009745_abnormal_behavioral_response0.64926035
98MP0000653_abnormal_sex_gland0.64409990
99MP0002723_abnormal_immune_serum0.64102715
100MP0004133_heterotaxia0.63388024

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.79462792
2Acute necrotizing encephalopathy (HP:0006965)4.43678845
3Mitochondrial inheritance (HP:0001427)4.32192038
43-Methylglutaconic aciduria (HP:0003535)4.17892073
5Abnormal mitochondria in muscle tissue (HP:0008316)4.13584253
6Increased CSF lactate (HP:0002490)3.96750710
7Hepatocellular necrosis (HP:0001404)3.96679862
8Acute encephalopathy (HP:0006846)3.86776236
9Aplastic anemia (HP:0001915)3.73090703
10Progressive macrocephaly (HP:0004481)3.68096472
11Hepatic necrosis (HP:0002605)3.61421490
12Increased hepatocellular lipid droplets (HP:0006565)3.42181617
13Lipid accumulation in hepatocytes (HP:0006561)3.24228414
14Pancreatic fibrosis (HP:0100732)3.15730223
15Pancreatic cysts (HP:0001737)3.13742710
16Macrocytic anemia (HP:0001972)3.07189254
17Cerebral edema (HP:0002181)3.03735814
18True hermaphroditism (HP:0010459)3.03254424
19Renal Fanconi syndrome (HP:0001994)3.03068443
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.97719153
21Chronic hepatic failure (HP:0100626)2.97340240
22Increased intramyocellular lipid droplets (HP:0012240)2.96989539
23Abnormality of cells of the erythroid lineage (HP:0012130)2.93324311
24Colon cancer (HP:0003003)2.85182820
25Abolished electroretinogram (ERG) (HP:0000550)2.81193112
26Congenital stationary night blindness (HP:0007642)2.80195187
27Abnormality of midbrain morphology (HP:0002418)2.78782571
28Molar tooth sign on MRI (HP:0002419)2.78782571
29Optic disc pallor (HP:0000543)2.78177874
30Abnormal number of erythroid precursors (HP:0012131)2.74534961
31Increased serum lactate (HP:0002151)2.58495414
32Increased muscle lipid content (HP:0009058)2.51700259
33Abnormal rod and cone electroretinograms (HP:0008323)2.51642172
34Respiratory difficulties (HP:0002880)2.50138279
35Concave nail (HP:0001598)2.47264540
36Pallor (HP:0000980)2.45771383
37Lactic acidosis (HP:0003128)2.41476557
38Decreased central vision (HP:0007663)2.41001469
39Hyperglycinemia (HP:0002154)2.36695372
40Glycosuria (HP:0003076)2.34980055
41Abnormality of urine glucose concentration (HP:0011016)2.34980055
42Medial flaring of the eyebrow (HP:0010747)2.31537836
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28209627
44IgG deficiency (HP:0004315)2.25622072
45Nephronophthisis (HP:0000090)2.24869324
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20628472
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20628472
48Attenuation of retinal blood vessels (HP:0007843)2.17582627
49Septo-optic dysplasia (HP:0100842)2.14312614
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13901937
51Respiratory failure (HP:0002878)2.13257038
52Exertional dyspnea (HP:0002875)2.11455117
53Abnormality of DNA repair (HP:0003254)2.11442633
54Increased IgM level (HP:0003496)2.11418105
55Abnormality of methionine metabolism (HP:0010901)2.09540394
56Constricted visual fields (HP:0001133)2.08950330
57T lymphocytopenia (HP:0005403)2.08530771
58Lethargy (HP:0001254)2.05901714
59Stenosis of the external auditory canal (HP:0000402)2.05334899
60Optic nerve hypoplasia (HP:0000609)2.02164065
61Absent thumb (HP:0009777)2.01674180
62Leukodystrophy (HP:0002415)1.99715628
63Abnormality of T cell number (HP:0011839)1.99401768
64CNS demyelination (HP:0007305)1.99083296
65Methylmalonic acidemia (HP:0002912)1.96807038
66Sclerocornea (HP:0000647)1.95155202
67Nephrogenic diabetes insipidus (HP:0009806)1.95060055
68Type 2 muscle fiber atrophy (HP:0003554)1.93662827
69Abnormality of the renal collecting system (HP:0004742)1.93429932
70Testicular atrophy (HP:0000029)1.92913705
71Depressed nasal ridge (HP:0000457)1.91992734
72Congenital primary aphakia (HP:0007707)1.91433310
73Exercise intolerance (HP:0003546)1.90925230
74Abnormality of the labia minora (HP:0012880)1.88705967
75Type I transferrin isoform profile (HP:0003642)1.87220285
76Renal cortical cysts (HP:0000803)1.86079153
77Pancytopenia (HP:0001876)1.85749288
78Intestinal atresia (HP:0011100)1.85525601
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85462395
80Abnormality of renal resorption (HP:0011038)1.83101736
81Gait imbalance (HP:0002141)1.82989136
82Aplasia/hypoplasia of the uterus (HP:0008684)1.82371405
83Methylmalonic aciduria (HP:0012120)1.82311633
84Male pseudohermaphroditism (HP:0000037)1.82196137
85Abnormality of the renal cortex (HP:0011035)1.81567808
86Abnormal respiratory motile cilium morphology (HP:0005938)1.80777604
87Abnormal respiratory epithelium morphology (HP:0012253)1.80777604
88Cystic liver disease (HP:0006706)1.79835494
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.78973352
90Absent/shortened dynein arms (HP:0200106)1.78973352
91Absent septum pellucidum (HP:0001331)1.78322806
92Hypoproteinemia (HP:0003075)1.77974866
93Anencephaly (HP:0002323)1.77513689
94Partial duplication of thumb phalanx (HP:0009944)1.77287341
95Abnormality of alanine metabolism (HP:0010916)1.77081210
96Hyperalaninemia (HP:0003348)1.77081210
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77081210
98Supernumerary spleens (HP:0009799)1.76313967
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75506737
100Elevated erythrocyte sedimentation rate (HP:0003565)1.73594832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.95782100
2MAP4K23.69093991
3VRK23.45328187
4BCKDK3.26072763
5ZAK2.94694789
6TLK12.91783947
7KDR2.65740703
8VRK12.47314735
9MAP3K122.39056414
10NUAK12.37314300
11CDK192.22507451
12TXK2.09579251
13MUSK2.05790028
14ADRBK22.01650890
15PDK21.96101674
16GRK11.89656401
17WNK41.81854621
18WNK31.80489058
19BMPR1B1.71895299
20FRK1.64515453
21TAOK31.56584130
22PASK1.51429532
23SRPK11.44201195
24TAF11.43571231
25MST41.42522150
26PINK11.41366577
27TRIM281.37212569
28DYRK21.23253836
29MAP3K41.22687538
30INSRR1.19833018
31TESK11.15141067
32MKNK11.05876048
33MAP2K71.05281262
34RPS6KA41.02225183
35BUB11.00141566
36TGFBR10.99138318
37PLK30.93797909
38LIMK10.91679090
39NME10.90484592
40PRKCQ0.88710666
41CDK80.87045664
42TIE10.86123786
43GRK70.81895070
44RPS6KA50.81719957
45ITK0.81075760
46MYLK0.74593809
47MAPK150.72236694
48OXSR10.71607768
49EPHA40.68189511
50DAPK10.68152938
51STK390.64580651
52BCR0.64515827
53SCYL20.63923150
54NEK10.63094933
55PIK3CA0.63086995
56PLK20.61507521
57DYRK1B0.61478514
58PRKCH0.60328614
59CAMK10.59937972
60GRK50.59363129
61MAP3K50.59213799
62DAPK30.57853998
63TEC0.56263109
64CDC70.56232100
65CSNK1G30.55569097
66MAPKAPK50.55354594
67SYK0.53730812
68PRKCG0.51519478
69MATK0.50981380
70CSNK2A20.50605771
71MAP3K110.49725746
72ILK0.49447178
73AURKB0.49206092
74CSNK1G20.49134276
75CSNK1G10.47460075
76OBSCN0.47444965
77PLK40.47039581
78FGFR20.46527290
79TNIK0.45185470
80MAPK130.44310722
81KIT0.43208518
82STK160.42952565
83IKBKB0.42651362
84LCK0.41663670
85CDK30.41326523
86MAP4K10.41324320
87PRKACA0.41153020
88CSNK2A10.40590009
89ADRBK10.40188111
90PLK10.39983379
91NEK20.39438055
92PIM10.38357363
93CSNK1A10.38245310
94PBK0.38032760
95WEE10.35276445
96TNK20.35150668
97PRKCE0.34961122
98ATR0.34761873
99EIF2AK30.34629403
100ERBB30.34329484

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.84757515
2Oxidative phosphorylation_Homo sapiens_hsa001904.25856900
3Parkinsons disease_Homo sapiens_hsa050123.76639307
4Proteasome_Homo sapiens_hsa030503.70592213
5Protein export_Homo sapiens_hsa030602.76245340
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57715915
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53741394
8Huntingtons disease_Homo sapiens_hsa050162.53519703
9Alzheimers disease_Homo sapiens_hsa050102.44711637
10Primary immunodeficiency_Homo sapiens_hsa053402.35351266
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23109291
12RNA polymerase_Homo sapiens_hsa030202.06417965
13Cardiac muscle contraction_Homo sapiens_hsa042601.99433571
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.77690175
15Caffeine metabolism_Homo sapiens_hsa002321.71710205
16Basal transcription factors_Homo sapiens_hsa030221.49464341
17Linoleic acid metabolism_Homo sapiens_hsa005911.49161132
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48141901
19Homologous recombination_Homo sapiens_hsa034401.45289291
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39821431
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38579363
22RNA degradation_Homo sapiens_hsa030181.37298191
23Propanoate metabolism_Homo sapiens_hsa006401.36334732
24Butanoate metabolism_Homo sapiens_hsa006501.30518150
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28236171
26Allograft rejection_Homo sapiens_hsa053301.24576559
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24353112
28Peroxisome_Homo sapiens_hsa041461.23662463
29Graft-versus-host disease_Homo sapiens_hsa053321.22948086
30Fanconi anemia pathway_Homo sapiens_hsa034601.22862849
31Asthma_Homo sapiens_hsa053101.19627651
32Nitrogen metabolism_Homo sapiens_hsa009101.18801663
33Phototransduction_Homo sapiens_hsa047441.18517333
34Autoimmune thyroid disease_Homo sapiens_hsa053201.17443345
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14195364
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11190088
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09659566
38Mismatch repair_Homo sapiens_hsa034301.07281898
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.07233629
40Chemical carcinogenesis_Homo sapiens_hsa052041.05523065
41Antigen processing and presentation_Homo sapiens_hsa046121.04489565
42Nucleotide excision repair_Homo sapiens_hsa034201.04224361
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.00054486
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99445744
45Retinol metabolism_Homo sapiens_hsa008300.99436773
46Type I diabetes mellitus_Homo sapiens_hsa049400.96890103
47Pyrimidine metabolism_Homo sapiens_hsa002400.96656028
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.93895279
49One carbon pool by folate_Homo sapiens_hsa006700.90939418
50RNA transport_Homo sapiens_hsa030130.90649716
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89417414
52Purine metabolism_Homo sapiens_hsa002300.85572000
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82316784
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81088474
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80764901
56Spliceosome_Homo sapiens_hsa030400.80326654
57Taste transduction_Homo sapiens_hsa047420.80268138
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79447383
59Metabolic pathways_Homo sapiens_hsa011000.78643792
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77935286
61Glutathione metabolism_Homo sapiens_hsa004800.74992777
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71997462
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.71969089
64Base excision repair_Homo sapiens_hsa034100.69259294
65Olfactory transduction_Homo sapiens_hsa047400.62190798
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.62147969
67Hematopoietic cell lineage_Homo sapiens_hsa046400.61207318
68Fat digestion and absorption_Homo sapiens_hsa049750.60635783
69Vitamin digestion and absorption_Homo sapiens_hsa049770.59989563
70Ether lipid metabolism_Homo sapiens_hsa005650.59275177
71Tryptophan metabolism_Homo sapiens_hsa003800.56098927
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56073724
73Sulfur relay system_Homo sapiens_hsa041220.53732008
74Basal cell carcinoma_Homo sapiens_hsa052170.53432008
75Pyruvate metabolism_Homo sapiens_hsa006200.53115005
76Arachidonic acid metabolism_Homo sapiens_hsa005900.52416016
77DNA replication_Homo sapiens_hsa030300.51719974
78Rheumatoid arthritis_Homo sapiens_hsa053230.51556073
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47492730
80Fatty acid elongation_Homo sapiens_hsa000620.44494983
81Fatty acid degradation_Homo sapiens_hsa000710.42589314
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38930054
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36249384
84Non-homologous end-joining_Homo sapiens_hsa034500.32345401
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32300484
86Tyrosine metabolism_Homo sapiens_hsa003500.32294007
87Nicotine addiction_Homo sapiens_hsa050330.31420713
88Hedgehog signaling pathway_Homo sapiens_hsa043400.30423971
89Starch and sucrose metabolism_Homo sapiens_hsa005000.28393516
90Folate biosynthesis_Homo sapiens_hsa007900.27877310
91Sulfur metabolism_Homo sapiens_hsa009200.26494955
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22725068
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19993490
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19808922
95Regulation of autophagy_Homo sapiens_hsa041400.18971381
96Steroid biosynthesis_Homo sapiens_hsa001000.17276652
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17021122
98Systemic lupus erythematosus_Homo sapiens_hsa053220.14791536
99Epstein-Barr virus infection_Homo sapiens_hsa051690.13874970
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13044829

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