RPL7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)8.45335429
2cell wall macromolecule metabolic process (GO:0044036)8.45335429
3* viral transcription (GO:0019083)5.88030296
4fusion of sperm to egg plasma membrane (GO:0007342)5.86618539
5* translational termination (GO:0006415)5.72022421
6ribosomal small subunit assembly (GO:0000028)5.43637257
7sperm-egg recognition (GO:0035036)5.17741722
8* translational elongation (GO:0006414)5.05883814
9multicellular organism reproduction (GO:0032504)4.94764128
10acrosome assembly (GO:0001675)4.87246048
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.77933995
12* translational initiation (GO:0006413)4.72477741
13* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70504424
14mitotic chromosome condensation (GO:0007076)4.68743319
15maturation of SSU-rRNA (GO:0030490)4.67904859
16cell-cell recognition (GO:0009988)4.65707325
17ribosomal small subunit biogenesis (GO:0042274)4.61407714
18* protein targeting to ER (GO:0045047)4.58701059
19* cotranslational protein targeting to membrane (GO:0006613)4.56877376
20* cellular protein complex disassembly (GO:0043624)4.53099108
21regulation of translational fidelity (GO:0006450)4.46336017
22binding of sperm to zona pellucida (GO:0007339)4.43371830
23* establishment of protein localization to endoplasmic reticulum (GO:0072599)4.38207033
24* viral life cycle (GO:0019058)4.38145294
25ribosomal large subunit biogenesis (GO:0042273)4.35987533
26reproduction (GO:0000003)4.30374398
27* protein localization to endoplasmic reticulum (GO:0070972)4.25340803
28* protein complex disassembly (GO:0043241)4.19995001
29plasma membrane fusion (GO:0045026)4.19325954
30DNA unwinding involved in DNA replication (GO:0006268)4.13529941
31protein localization to kinetochore (GO:0034501)4.09968591
32formation of translation preinitiation complex (GO:0001731)4.03776240
33nuclear pore complex assembly (GO:0051292)3.97269338
34cilium or flagellum-dependent cell motility (GO:0001539)3.91365558
35* macromolecular complex disassembly (GO:0032984)3.89073469
36nuclear pore organization (GO:0006999)3.87183838
37spermatid nucleus differentiation (GO:0007289)3.82288960
38DNA replication-dependent nucleosome assembly (GO:0006335)3.80727169
39DNA replication-dependent nucleosome organization (GO:0034723)3.80727169
40DNA strand elongation involved in DNA replication (GO:0006271)3.65208451
41* nuclear-transcribed mRNA catabolic process (GO:0000956)3.59573965
42DNA replication initiation (GO:0006270)3.56865095
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55763353
44protein localization to chromosome, centromeric region (GO:0071459)3.53357032
45mitotic nuclear envelope disassembly (GO:0007077)3.47763639
46DNA strand elongation (GO:0022616)3.46244488
47* establishment of protein localization to membrane (GO:0090150)3.45693014
48folic acid-containing compound biosynthetic process (GO:0009396)3.39053143
49* ribonucleoprotein complex biogenesis (GO:0022613)3.38765716
50* mRNA catabolic process (GO:0006402)3.38642667
51proline biosynthetic process (GO:0006561)3.36207660
52DNA topological change (GO:0006265)3.33190961
53* RNA catabolic process (GO:0006401)3.30790070
54* cellular component biogenesis (GO:0044085)3.21491019
55nuclear envelope disassembly (GO:0051081)3.21111889
56membrane disassembly (GO:0030397)3.21111889
57* ribosome biogenesis (GO:0042254)3.20741685
58telomere maintenance via semi-conservative replication (GO:0032201)3.19073350
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.18513029
60rRNA processing (GO:0006364)3.16506609
61nucleobase biosynthetic process (GO:0046112)3.16394951
62ncRNA 3-end processing (GO:0043628)3.14873871
63* translation (GO:0006412)3.14042332
64regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12317282
65histone exchange (GO:0043486)3.07718412
66rRNA metabolic process (GO:0016072)3.05642318
67DNA replication checkpoint (GO:0000076)3.05549419
68pore complex assembly (GO:0046931)3.03594525
69IMP biosynthetic process (GO:0006188)3.02290523
70monoubiquitinated protein deubiquitination (GO:0035520)3.00621523
71chaperone-mediated protein complex assembly (GO:0051131)3.00334292
72* establishment of protein localization to organelle (GO:0072594)3.00244715
73* protein targeting to membrane (GO:0006612)3.00153804
74* protein targeting (GO:0006605)3.00002414
75microtubule depolymerization (GO:0007019)2.97467507
76regulation of RNA export from nucleus (GO:0046831)2.96883885
77spliceosomal snRNP assembly (GO:0000387)2.96673410
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94348876
79regulation of histone H3-K9 methylation (GO:0051570)2.93313051
80protein K6-linked ubiquitination (GO:0085020)2.91919146
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91463885
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.90647472
83regulation of centriole replication (GO:0046599)2.90186825
84peptidyl-lysine dimethylation (GO:0018027)2.89679211
85ribosome assembly (GO:0042255)2.89383012
86mitotic metaphase plate congression (GO:0007080)2.88504310
87synaptonemal complex assembly (GO:0007130)2.88391983
88negative regulation of mRNA processing (GO:0050686)2.87869753
89telomere maintenance via recombination (GO:0000722)2.87779672
90DNA duplex unwinding (GO:0032508)2.86410521
91motile cilium assembly (GO:0044458)2.86361539
92DNA geometric change (GO:0032392)2.85368495
93chromatin remodeling at centromere (GO:0031055)2.83919602
94chromatin assembly (GO:0031497)2.83302732
95pre-miRNA processing (GO:0031054)2.82827672
96chromosome condensation (GO:0030261)2.82218584
97establishment of integrated proviral latency (GO:0075713)2.81933483
98heterochromatin organization (GO:0070828)2.81704568
99peptidyl-arginine omega-N-methylation (GO:0035247)2.81062944
100viral mRNA export from host cell nucleus (GO:0046784)2.80986233
101mitotic recombination (GO:0006312)2.80199347
102DNA deamination (GO:0045006)2.79518795
103negative regulation of RNA splicing (GO:0033119)2.78426555
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.77753514
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77753514
106chromatin assembly or disassembly (GO:0006333)2.76294782
107kinetochore organization (GO:0051383)2.75421361
108purine nucleobase biosynthetic process (GO:0009113)2.75283662
109CENP-A containing nucleosome assembly (GO:0034080)2.75282875
110IMP metabolic process (GO:0046040)2.75250522
111nucleobase-containing small molecule interconversion (GO:0015949)2.74042808
112mitotic sister chromatid segregation (GO:0000070)2.74026504
113spermatid development (GO:0007286)2.73047785
114regulation of spindle organization (GO:0090224)2.72912659
115* protein localization to membrane (GO:0072657)2.72442819
116protein complex localization (GO:0031503)2.72388611
117sperm motility (GO:0030317)2.71815201
118male meiosis (GO:0007140)2.71729478
119sister chromatid segregation (GO:0000819)2.71445256
120DNA replication-independent nucleosome assembly (GO:0006336)2.71216972
121DNA replication-independent nucleosome organization (GO:0034724)2.71216972
122termination of RNA polymerase II transcription (GO:0006369)2.70408632
123regulation of gene silencing by RNA (GO:0060966)2.68106478
124regulation of gene silencing by miRNA (GO:0060964)2.68106478
125DNA synthesis involved in DNA repair (GO:0000731)2.67187771
126* gene expression (GO:0010467)2.66235986
127negative regulation of mRNA metabolic process (GO:1903312)2.66144826
128mRNA stabilization (GO:0048255)2.65056634
129RNA stabilization (GO:0043489)2.65056634
130* cellular component disassembly (GO:0022411)2.64730285
131Golgi transport vesicle coating (GO:0048200)2.64193381
132COPI coating of Golgi vesicle (GO:0048205)2.64193381
133regulation of chromatin binding (GO:0035561)2.63319659
134negative regulation of DNA repair (GO:0045738)2.61731136
135nucleosome disassembly (GO:0006337)2.61455532
136protein-DNA complex disassembly (GO:0032986)2.61455532
137DNA conformation change (GO:0071103)2.60110563
138cellular protein complex localization (GO:0034629)2.57018769
139rRNA transcription (GO:0009303)2.56509656
140myeloid cell homeostasis (GO:0002262)2.53491230
141ribonucleoprotein complex assembly (GO:0022618)2.50523713
142mitochondrial fusion (GO:0008053)2.49413732
143regulation of translational initiation (GO:0006446)2.46343095
1443-UTR-mediated mRNA stabilization (GO:0070935)2.45172787
145mitotic sister chromatid cohesion (GO:0007064)2.44793671
146folic acid metabolic process (GO:0046655)2.44710947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.92485654
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.40584837
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.28355047
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.05640988
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55754488
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54548672
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18853318
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96945836
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68425755
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56169179
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.44947538
12* XRN2_22483619_ChIP-Seq_HELA_Human2.43371063
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36216779
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.24719489
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.19286835
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16887956
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10305588
18MYC_22102868_ChIP-Seq_BL_Human2.09570791
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09241830
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06087029
21AR_21909140_ChIP-Seq_LNCAP_Human2.00648041
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94633632
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87487860
24* VDR_23849224_ChIP-Seq_CD4+_Human1.87416686
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85535954
26ZNF263_19887448_ChIP-Seq_K562_Human1.84328604
27* TTF2_22483619_ChIP-Seq_HELA_Human1.81707912
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80947777
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78056722
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.77087781
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74066526
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72971899
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.70962431
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69187506
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56798933
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56285083
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54281256
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52626820
39GABP_19822575_ChIP-Seq_HepG2_Human1.51825799
40DCP1A_22483619_ChIP-Seq_HELA_Human1.51541647
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51027748
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49635383
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48324953
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45619656
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45402929
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42714721
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40386730
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37623595
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37219873
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35678012
51CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35193666
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35080196
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33594328
54CIITA_25753668_ChIP-Seq_RAJI_Human1.32212980
55ELK1_19687146_ChIP-ChIP_HELA_Human1.30963160
56KDM5A_27292631_Chip-Seq_BREAST_Human1.30286191
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29788045
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29522504
59RACK7_27058665_Chip-Seq_MCF-7_Human1.28224204
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27334694
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.27008984
62LXR_22292898_ChIP-Seq_THP-1_Human1.26351645
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24906205
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24520213
65VDR_21846776_ChIP-Seq_THP-1_Human1.20157122
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.19820030
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18174361
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17225251
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13158024
70* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11593082
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10280332
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.09819809
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09392973
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09276303
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09067217
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08716716
77* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08462948
78* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08344361
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08077116
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07410216
81TCF7_22412390_ChIP-Seq_EML_Mouse1.06931492
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06037340
83* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05853541
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04912885
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04746531
86NCOR1_26117541_ChIP-Seq_K562_Human1.04170823
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03926516
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03545116
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03124264
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02674391
91SCL_19346495_ChIP-Seq_HPC-7_Human1.02073756
92* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01257046
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98726611
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.98389652
95* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98362512
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97681846
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96815226
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96722288
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96023591
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95952661
101KDM2B_26808549_Chip-Seq_DND41_Human0.94542424
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93936969
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93504775
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93420365
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93201341
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.93147490
107P68_20966046_ChIP-Seq_HELA_Human0.92260120
108TFEB_21752829_ChIP-Seq_HELA_Human0.92046350
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91526288
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91493541
111MAF_26560356_Chip-Seq_TH2_Human0.90984089
112MYC_18940864_ChIP-ChIP_HL60_Human0.90864565
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90468655
114* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88498193
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86025057
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85689108
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.84862729
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82369942
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.80645245
120UTX_26944678_Chip-Seq_JUKART_Human0.79423812
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78612884
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75768342
123SPI1_23547873_ChIP-Seq_NB4_Human0.73698216
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.71493996
125CHD1_26751641_Chip-Seq_LNCaP_Human0.71264278
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71143709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.87189557
2MP0010094_abnormal_chromosome_stability3.66113098
3MP0004957_abnormal_blastocyst_morpholog3.56380577
4MP0003111_abnormal_nucleus_morphology3.37410371
5MP0003077_abnormal_cell_cycle3.13842941
6MP0008057_abnormal_DNA_replication2.96901481
7MP0005410_abnormal_fertilization2.95159826
8MP0008058_abnormal_DNA_repair2.86152147
9MP0010352_gastrointestinal_tract_polyps2.67420198
10MP0010307_abnormal_tumor_latency2.20296394
11MP0001730_embryonic_growth_arrest2.20001935
12MP0008007_abnormal_cellular_replicative2.18809611
13MP0002396_abnormal_hematopoietic_system2.12831576
14MP0003705_abnormal_hypodermis_morpholog2.11167054
15MP0002877_abnormal_melanocyte_morpholog2.08659832
16MP0002653_abnormal_ependyma_morphology2.07234160
17MP0008932_abnormal_embryonic_tissue1.94870749
18MP0008877_abnormal_DNA_methylation1.94705791
19MP0000350_abnormal_cell_proliferation1.86227764
20MP0001929_abnormal_gametogenesis1.79907343
21MP0004185_abnormal_adipocyte_glucose1.77436943
22MP0003123_paternal_imprinting1.75636296
23MP0000566_synostosis1.72524538
24MP0000490_abnormal_crypts_of1.68514867
25MP0004808_abnormal_hematopoietic_stem1.66368982
26MP0001697_abnormal_embryo_size1.64535839
27MP0005380_embryogenesis_phenotype1.61754661
28MP0001672_abnormal_embryogenesis/_devel1.61754661
29MP0002210_abnormal_sex_determination1.60662538
30MP0004197_abnormal_fetal_growth/weight/1.58581604
31MP0004858_abnormal_nervous_system1.57183571
32MP0002009_preneoplasia1.54816440
33MP0002163_abnormal_gland_morphology1.54315679
34MP0003984_embryonic_growth_retardation1.54147499
35MP0002084_abnormal_developmental_patter1.53887148
36MP0002085_abnormal_embryonic_tissue1.52444921
37MP0002080_prenatal_lethality1.52065411
38MP0002088_abnormal_embryonic_growth/wei1.51195785
39MP0003698_abnormal_male_reproductive1.49684333
40MP0001145_abnormal_male_reproductive1.48674575
41MP0005076_abnormal_cell_differentiation1.48030659
42MP0000678_abnormal_parathyroid_gland1.47921160
43MP0006054_spinal_hemorrhage1.45760461
44MP0003786_premature_aging1.43748194
45MP0002086_abnormal_extraembryonic_tissu1.42509607
46MP0001346_abnormal_lacrimal_gland1.41299352
47MP0003763_abnormal_thymus_physiology1.37996419
48MP0005451_abnormal_body_composition1.37375584
49MP0001293_anophthalmia1.35871243
50MP0002019_abnormal_tumor_incidence1.35474169
51MP0006292_abnormal_olfactory_placode1.34736917
52MP0000537_abnormal_urethra_morphology1.34504451
53MP0000313_abnormal_cell_death1.33229121
54MP0001348_abnormal_lacrimal_gland1.32108118
55MP0003567_abnormal_fetal_cardiomyocyte1.30394383
56MP0004264_abnormal_extraembryonic_tissu1.30359332
57MP0005623_abnormal_meninges_morphology1.27299500
58MP0002249_abnormal_larynx_morphology1.24503323
59MP0000653_abnormal_sex_gland1.24184021
60MP0010030_abnormal_orbit_morphology1.17522995
61MP0000703_abnormal_thymus_morphology1.17076895
62MP0009333_abnormal_splenocyte_physiolog1.09355060
63MP0009053_abnormal_anal_canal1.08903504
64MP0005397_hematopoietic_system_phenotyp1.08742844
65MP0001545_abnormal_hematopoietic_system1.08742844
66MP0003942_abnormal_urinary_system1.08293264
67MP0005023_abnormal_wound_healing1.05283639
68MP0001661_extended_life_span1.04788559
69MP0002282_abnormal_trachea_morphology1.03595388
70MP0003566_abnormal_cell_adhesion1.02346789
71MP0003890_abnormal_embryonic-extraembry1.02007792
72MP0002398_abnormal_bone_marrow1.00047025
73MP0001873_stomach_inflammation0.98741890
74MP0009379_abnormal_foot_pigmentation0.98222719
75MP0002722_abnormal_immune_system0.96162246
76MP0000762_abnormal_tongue_morphology0.95589684
77MP0000858_altered_metastatic_potential0.92631225
78MP0002161_abnormal_fertility/fecundity0.91395349
79MP0005501_abnormal_skin_physiology0.91364277
80MP0003119_abnormal_digestive_system0.91153606
81MP0001849_ear_inflammation0.90075625
82MP0003453_abnormal_keratinocyte_physiol0.88511706
83MP0004233_abnormal_muscle_weight0.88155204
84MP0002102_abnormal_ear_morphology0.87465556
85MP0001286_abnormal_eye_development0.87406804
86MP0000733_abnormal_muscle_development0.87018353
87MP0003941_abnormal_skin_development0.86887747
88MP0008995_early_reproductive_senescence0.86819408
89MP0001881_abnormal_mammary_gland0.86195280
90MP0002132_abnormal_respiratory_system0.86040450
91MP0002160_abnormal_reproductive_system0.85396870
92MP0010234_abnormal_vibrissa_follicle0.85154678
93MP0000049_abnormal_middle_ear0.84992921
94MP0002089_abnormal_postnatal_growth/wei0.84546907
95MP0000689_abnormal_spleen_morphology0.83540971
96MP0001915_intracranial_hemorrhage0.83249978
97MP0009278_abnormal_bone_marrow0.83043911
98MP0009672_abnormal_birth_weight0.82483900
99MP0003385_abnormal_body_wall0.82395255
100MP0002092_abnormal_eye_morphology0.81965899
101MP0005666_abnormal_adipose_tissue0.81316238
102MP0004133_heterotaxia0.78516685
103MP0000477_abnormal_intestine_morphology0.78491337
104MP0003806_abnormal_nucleotide_metabolis0.77958738
105MP0003121_genomic_imprinting0.77925053
106MP0002429_abnormal_blood_cell0.76800076
107MP0002098_abnormal_vibrissa_morphology0.76786821
108MP0002111_abnormal_tail_morphology0.75877046
109MP0005409_darkened_coat_color0.75291089
110MP0000627_abnormal_mammary_gland0.75179667
111MP0000358_abnormal_cell_content/0.75051785
112MP0003937_abnormal_limbs/digits/tail_de0.75014312
113MP0004782_abnormal_surfactant_physiolog0.72261523
114MP0002697_abnormal_eye_size0.71594009
115MP0003861_abnormal_nervous_system0.70889170
116MP0002114_abnormal_axial_skeleton0.70140076
117MP0008260_abnormal_autophagy0.69207728
118MP0000432_abnormal_head_morphology0.69038761
119MP0001340_abnormal_eyelid_morphology0.68935588
120MP0002405_respiratory_system_inflammati0.68383467
121MP0005220_abnormal_exocrine_pancreas0.67604806
122MP0000685_abnormal_immune_system0.67509870
123MP0000750_abnormal_muscle_regeneration0.67418939
124MP0009250_abnormal_appendicular_skeleto0.67204566
125MP0005621_abnormal_cell_physiology0.66849833
126MP0002166_altered_tumor_susceptibility0.66734793
127MP0009703_decreased_birth_body0.66295520
128MP0000716_abnormal_immune_system0.64980011
129MP0002925_abnormal_cardiovascular_devel0.64139131
130MP0001216_abnormal_epidermal_layer0.63676225
131MP0005275_abnormal_skin_tensile0.63548149
132MP0002796_impaired_skin_barrier0.63062818
133MP0000428_abnormal_craniofacial_morphol0.62688196
134MP0000377_abnormal_hair_follicle0.60893594
135MP0003115_abnormal_respiratory_system0.59469571
136MP0003315_abnormal_perineum_morphology0.59004907
137MP0001119_abnormal_female_reproductive0.57237802

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.40644303
2Reticulocytopenia (HP:0001896)5.22642471
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.21820945
4Abnormal number of erythroid precursors (HP:0012131)4.81503524
5Tongue fasciculations (HP:0001308)4.46965685
6Muscle fibrillation (HP:0010546)4.14915513
7Nasal polyposis (HP:0100582)3.83344925
8Macrocytic anemia (HP:0001972)3.55682607
9Pallor (HP:0000980)3.52705075
10Selective tooth agenesis (HP:0001592)3.45951344
11Birth length less than 3rd percentile (HP:0003561)3.37972732
12Colon cancer (HP:0003003)3.36639355
13Absent/shortened dynein arms (HP:0200106)3.32672940
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.32672940
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20745799
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20439896
17Abnormality of the nasal mucosa (HP:0000433)3.19729182
18Chronic bronchitis (HP:0004469)3.14959121
19Progressive muscle weakness (HP:0003323)3.13319521
20Increased nuchal translucency (HP:0010880)2.83441384
21Abnormal respiratory motile cilium physiology (HP:0012261)2.79443195
22Rhinitis (HP:0012384)2.78300511
2311 pairs of ribs (HP:0000878)2.73310126
24Microvesicular hepatic steatosis (HP:0001414)2.71831357
25Broad distal phalanx of finger (HP:0009836)2.70667651
26Bronchitis (HP:0012387)2.67631388
27Abnormal respiratory motile cilium morphology (HP:0005938)2.65724676
28Abnormal respiratory epithelium morphology (HP:0012253)2.65724676
29Thrombocytosis (HP:0001894)2.56160398
30Ependymoma (HP:0002888)2.54177389
31Deep palmar crease (HP:0006191)2.45898422
32Chronic otitis media (HP:0000389)2.42232426
33Missing ribs (HP:0000921)2.37048201
34Medulloblastoma (HP:0002885)2.36928611
35Recurrent bronchitis (HP:0002837)2.36079566
36Duplication of thumb phalanx (HP:0009942)2.35836695
37Facial cleft (HP:0002006)2.34046979
38Proximal placement of thumb (HP:0009623)2.31035146
39Abnormality of reticulocytes (HP:0004312)2.30950861
40Atresia of the external auditory canal (HP:0000413)2.29013723
41Breast hypoplasia (HP:0003187)2.28053250
42Deviation of the thumb (HP:0009603)2.26550069
43Abnormal ciliary motility (HP:0012262)2.24274618
44Overlapping toe (HP:0001845)2.24069295
45Absent thumb (HP:0009777)2.23156472
46Neoplasm of the pancreas (HP:0002894)2.22641584
47Progressive external ophthalmoplegia (HP:0000590)2.22639068
48Asymmetry of the thorax (HP:0001555)2.21829971
49Oral leukoplakia (HP:0002745)2.21392548
50Basal cell carcinoma (HP:0002671)2.21368849
51Trismus (HP:0000211)2.19906470
52Ankyloglossia (HP:0010296)2.19494339
53Aplastic anemia (HP:0001915)2.17173368
54Insomnia (HP:0100785)2.17030540
55Long palpebral fissure (HP:0000637)2.16909378
56Partial duplication of thumb phalanx (HP:0009944)2.16011784
57Abnormality of the anterior horn cell (HP:0006802)2.15999275
58Degeneration of anterior horn cells (HP:0002398)2.15999275
59Flat acetabular roof (HP:0003180)2.12243778
60Hyperacusis (HP:0010780)2.12128257
61Multiple enchondromatosis (HP:0005701)2.11498793
62Patellar aplasia (HP:0006443)2.10145249
63Impulsivity (HP:0100710)2.09104716
64Rectal prolapse (HP:0002035)2.08504989
65Partial duplication of the phalanx of hand (HP:0009999)2.08361246
66Abnormality of cochlea (HP:0000375)2.07677146
67High anterior hairline (HP:0009890)2.06800498
68Abnormality of the phalanges of the hallux (HP:0010057)2.06596320
69Bronchiectasis (HP:0002110)2.06396641
70Sparse lateral eyebrow (HP:0005338)2.05765596
71Premature skin wrinkling (HP:0100678)2.03155637
72Abnormal lung lobation (HP:0002101)2.02857792
73Supernumerary spleens (HP:0009799)2.02767918
74Diastasis recti (HP:0001540)2.02346715
75Myelodysplasia (HP:0002863)2.01407917
76Short 4th metacarpal (HP:0010044)2.01266859
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01266859
78Aplasia/Hypoplasia of the patella (HP:0006498)1.99461149
79Renal duplication (HP:0000075)1.98966666
80Rhabdomyosarcoma (HP:0002859)1.98841364
81Abnormality of the distal phalanx of the thumb (HP:0009617)1.95106461
82Abnormality of the thoracic spine (HP:0100711)1.94764930
83Septate vagina (HP:0001153)1.94571650
84Overriding aorta (HP:0002623)1.92533753
85Thick lower lip vermilion (HP:0000179)1.91111769
86Abnormality of the fingertips (HP:0001211)1.90718152
87Truncus arteriosus (HP:0001660)1.90580540
88Agnosia (HP:0010524)1.90492663
89Ragged-red muscle fibers (HP:0003200)1.90002239
90Disproportionate tall stature (HP:0001519)1.89249743
91Horseshoe kidney (HP:0000085)1.89007675
92Deep philtrum (HP:0002002)1.88287942
93Abnormal spermatogenesis (HP:0008669)1.88086148
94Syringomyelia (HP:0003396)1.87473712
95Spinal cord lesions (HP:0100561)1.87473712
96High pitched voice (HP:0001620)1.87110399
97Carpal bone hypoplasia (HP:0001498)1.87073120
98Abnormal hemoglobin (HP:0011902)1.86861711
99Metaphyseal cupping (HP:0003021)1.83959394
100Renovascular hypertension (HP:0100817)1.83868295
101Biliary tract neoplasm (HP:0100574)1.83750599
102Abnormality of the parietal bone (HP:0002696)1.81756175
103Sloping forehead (HP:0000340)1.80739682
104Small intestinal stenosis (HP:0012848)1.78597961
105Duodenal stenosis (HP:0100867)1.78597961
106Breast carcinoma (HP:0003002)1.77897425
107Chromsome breakage (HP:0040012)1.77694664
108Recurrent sinusitis (HP:0011108)1.77528403
109Reticulocytosis (HP:0001923)1.77504876
110Bicuspid aortic valve (HP:0001647)1.76521394
111Chronic sinusitis (HP:0011109)1.75729893
112Fasciculations (HP:0002380)1.75722177
113Neoplasm of the colon (HP:0100273)1.75333113
114Absent radius (HP:0003974)1.75084982
115Thoracic kyphosis (HP:0002942)1.74124663
116Abnormality of DNA repair (HP:0003254)1.73907276
117Abnormality of oral frenula (HP:0000190)1.73740771
118Pseudobulbar signs (HP:0002200)1.72354680
119Amaurosis fugax (HP:0100576)1.71342691
120Microretrognathia (HP:0000308)1.70414289
121Abnormality of the calcaneus (HP:0008364)1.70324892
122Achilles tendon contracture (HP:0001771)1.70298521
123Rough bone trabeculation (HP:0100670)1.69269072
124Dysmetric saccades (HP:0000641)1.69205568
125Ovarian neoplasm (HP:0100615)1.67855528
126Elfin facies (HP:0004428)1.66115824
127Hypoparathyroidism (HP:0000829)1.65866324
128Increased density of long bones (HP:0006392)1.65616990
129Glossoptosis (HP:0000162)1.65131391
130Depressed nasal ridge (HP:0000457)1.64502528
131Abnormality of chromosome stability (HP:0003220)1.63713849
132Squamous cell carcinoma (HP:0002860)1.63516562
133Patellar dislocation (HP:0002999)1.62505328
134Tracheoesophageal fistula (HP:0002575)1.62125640
135Gout (HP:0001997)1.61412905
136Meckel diverticulum (HP:0002245)1.61316973
137Pointed chin (HP:0000307)1.59129598
138Abnormal number of incisors (HP:0011064)1.59049583
139Spastic diplegia (HP:0001264)1.58462040
140Aplasia involving forearm bones (HP:0009822)1.58148132
141Absent forearm bone (HP:0003953)1.58148132
142Nephroblastoma (Wilms tumor) (HP:0002667)1.57974439
143Abnormality of the salivary glands (HP:0010286)1.57141486
144Triphalangeal thumb (HP:0001199)1.57127640
145Abnormality of abdominal situs (HP:0011620)1.55975333
146Abdominal situs inversus (HP:0003363)1.55975333
147Preauricular skin tag (HP:0000384)1.55606100
148Premature ovarian failure (HP:0008209)1.55153382
149Poikiloderma (HP:0001029)1.54287705
150Abnormality of the ileum (HP:0001549)1.54188267
151Abnormality of the preputium (HP:0100587)1.53795322
152Hypoplasia of the radius (HP:0002984)1.53746256
153Abnormality of glycolysis (HP:0004366)1.53386054
154Testicular atrophy (HP:0000029)1.52327975
155Cafe-au-lait spot (HP:0000957)1.46531627
156Seborrheic dermatitis (HP:0001051)1.45120746
157Morphological abnormality of the inner ear (HP:0011390)1.44686549
158Delayed cranial suture closure (HP:0000270)1.42128238
159Respiratory difficulties (HP:0002880)1.40861683
160Flared metaphyses (HP:0003015)1.40644244
161Myopathic facies (HP:0002058)1.40211664
162Choanal atresia (HP:0000453)1.38176007
163Abnormality of nail color (HP:0100643)1.38034702
164Skin tags (HP:0010609)1.37365775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.91605520
2PDK33.76710951
3PDK43.76710951
4WEE13.44323188
5EEF2K3.24391378
6CDC73.15154428
7BUB12.90876221
8PRPF4B2.59622144
9NEK22.56812843
10NME22.55146206
11ICK2.51770973
12PDK22.22431676
13CDK122.22252343
14RPS6KB22.21983225
15PASK2.17964821
16PKN22.14991812
17BRSK21.98710624
18MAP3K101.94950781
19NEK11.70491830
20VRK21.68027312
21TTK1.65265456
22TLK11.60709018
23TSSK61.60174157
24CDK191.59421622
25IRAK31.56465905
26PLK41.54017887
27TGFBR11.52695660
28LRRK21.52507974
29SRPK11.51156150
30TESK21.49722610
31SCYL21.49404584
32DYRK31.48948635
33EPHA21.48664176
34EIF2AK11.48413193
35TAF11.47907320
36STK101.46399755
37SIK11.44338448
38PBK1.43191878
39CDK71.41172142
40AURKB1.38982756
41PLK11.38124733
42MKNK11.35420237
43TRIB31.33948801
44ACVR1B1.32649011
45CDK41.32434253
46RPS6KA41.32212582
47ATR1.32187781
48MAP4K11.26360574
49BRAF1.25571511
50CHEK21.24440026
51MAP3K81.21573170
52PAK41.16618556
53FLT31.13931351
54CHEK11.12198578
55VRK11.10462406
56KSR21.09400894
57PIM11.01033334
58MAP3K131.00256205
59FGFR40.97928915
60ZAP700.93693902
61EIF2AK30.92188591
62CDK60.91127858
63AURKA0.89826534
64ARAF0.88752644
65STK40.88621877
66BRSK10.84818447
67TTN0.82322200
68LATS20.81962130
69ILK0.79450930
70CDK80.79236394
71TESK10.77983579
72MAP3K90.77865994
73PLK30.76701806
74PIM20.74511340
75CSNK2A20.72979698
76STK30.71638511
77ATM0.71476514
78CLK10.70503806
79MKNK20.70146700
80TYRO30.69325525
81CDK20.68302685
82ALK0.68238259
83PAK20.67589644
84MAPKAPK30.66690992
85KDR0.62658098
86PAK10.61821787
87TAOK20.61139885
88PDGFRA0.61083226
89MTOR0.60767027
90ZAK0.60171676
91BTK0.59855778
92GRK60.59783727
93PTK60.59656776
94MAP2K30.58562519
95BRD40.58271302
96MELK0.57344303
97PRKD30.54178416
98LATS10.52226899
99RAF10.50985089
100CSNK2A10.48795738
101NME10.47809942
102IRAK20.47149938
103RPS6KA60.46228884
104MAP2K20.45570562
105MOS0.45377067
106CAMK1D0.44484765
107RPS6KB10.43580970
108RPS6KA50.43547209
109MARK30.42832633
110PRKCI0.41715595
111CDK10.41645401
112STK160.41156405
113MAPK110.40733341
114AKT20.39467045
115MAP3K30.38914628
116CDK11A0.38638640
117ERN10.38140718
118STK240.38069027
119CDK90.37318758
120MST40.36375822
121RIPK10.34850625
122PDPK10.34238524
123PTK20.34203473
124FGFR10.33821564
125DAPK30.33751607
126MST1R0.30339072
127MAPKAPK20.29016507
128RPS6KA10.28722548
129CSF1R0.27455838
130CSNK1E0.27196861
131LMTK20.26606796
132PRKDC0.26397310
133JAK30.26294037
134BMX0.23322513
135CCNB10.22860198
136RPS6KL10.21413252
137RPS6KC10.21413252

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030104.83682073
2DNA replication_Homo sapiens_hsa030304.20879781
3Mismatch repair_Homo sapiens_hsa034303.53936222
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49196538
5Spliceosome_Homo sapiens_hsa030403.26257541
6RNA transport_Homo sapiens_hsa030133.07457120
7Base excision repair_Homo sapiens_hsa034102.52252327
8Homologous recombination_Homo sapiens_hsa034402.50267940
9Cell cycle_Homo sapiens_hsa041102.44396736
10Nucleotide excision repair_Homo sapiens_hsa034202.39181939
11One carbon pool by folate_Homo sapiens_hsa006702.38499260
12Proteasome_Homo sapiens_hsa030502.35058724
13RNA polymerase_Homo sapiens_hsa030202.25230194
14Systemic lupus erythematosus_Homo sapiens_hsa053222.20005247
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11923054
16Basal transcription factors_Homo sapiens_hsa030222.01216015
17Pyrimidine metabolism_Homo sapiens_hsa002401.99205118
18Fanconi anemia pathway_Homo sapiens_hsa034601.89373293
19mRNA surveillance pathway_Homo sapiens_hsa030151.76358904
20Pentose phosphate pathway_Homo sapiens_hsa000301.73804059
21Non-homologous end-joining_Homo sapiens_hsa034501.65529150
22p53 signaling pathway_Homo sapiens_hsa041151.60631175
23RNA degradation_Homo sapiens_hsa030181.55862499
24Viral carcinogenesis_Homo sapiens_hsa052031.32220072
25Antigen processing and presentation_Homo sapiens_hsa046121.29875590
26Biosynthesis of amino acids_Homo sapiens_hsa012301.18219679
27Selenocompound metabolism_Homo sapiens_hsa004501.14755872
28Epstein-Barr virus infection_Homo sapiens_hsa051691.12360489
29Pancreatic cancer_Homo sapiens_hsa052121.11569416
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05796619
31Purine metabolism_Homo sapiens_hsa002301.05334691
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02577287
33Herpes simplex infection_Homo sapiens_hsa051680.98323378
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96413122
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94370950
36Endometrial cancer_Homo sapiens_hsa052130.92692173
37HTLV-I infection_Homo sapiens_hsa051660.89893558
38Small cell lung cancer_Homo sapiens_hsa052220.89577423
39Oocyte meiosis_Homo sapiens_hsa041140.88950323
40Carbon metabolism_Homo sapiens_hsa012000.86852222
41Renin-angiotensin system_Homo sapiens_hsa046140.84511284
42mTOR signaling pathway_Homo sapiens_hsa041500.80972014
43VEGF signaling pathway_Homo sapiens_hsa043700.80764638
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.78651558
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74703680
46N-Glycan biosynthesis_Homo sapiens_hsa005100.74185769
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73762408
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.73523314
49Legionellosis_Homo sapiens_hsa051340.73346185
50MicroRNAs in cancer_Homo sapiens_hsa052060.72021824
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71853154
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71286861
53Alcoholism_Homo sapiens_hsa050340.71239972
54Thyroid cancer_Homo sapiens_hsa052160.70229364
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69590384
56Primary immunodeficiency_Homo sapiens_hsa053400.69365583
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65793077
58Sulfur relay system_Homo sapiens_hsa041220.65762796
59Galactose metabolism_Homo sapiens_hsa000520.65601466
60ErbB signaling pathway_Homo sapiens_hsa040120.65303819
61Renal cell carcinoma_Homo sapiens_hsa052110.63674066
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63615070
63Glutathione metabolism_Homo sapiens_hsa004800.63196247
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62450756
65Chronic myeloid leukemia_Homo sapiens_hsa052200.61990710
66Huntingtons disease_Homo sapiens_hsa050160.60606025
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60430140
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60107557
69Lysine degradation_Homo sapiens_hsa003100.58232006
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58003575
71Basal cell carcinoma_Homo sapiens_hsa052170.58002044
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.57884718
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56784450
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.56230069
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54865208
76Glioma_Homo sapiens_hsa052140.54433570
77Hippo signaling pathway_Homo sapiens_hsa043900.52905420
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.51121564
79Prion diseases_Homo sapiens_hsa050200.50517737
80Insulin signaling pathway_Homo sapiens_hsa049100.50321936
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.49436389
82Adherens junction_Homo sapiens_hsa045200.48986530
83Apoptosis_Homo sapiens_hsa042100.48023881
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47991664
85Bladder cancer_Homo sapiens_hsa052190.47379112
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47042243
87Protein export_Homo sapiens_hsa030600.46569127
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45241194
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44819740
90Melanoma_Homo sapiens_hsa052180.44816661
91TGF-beta signaling pathway_Homo sapiens_hsa043500.44698575
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43566403
93Parkinsons disease_Homo sapiens_hsa050120.42689811
94Viral myocarditis_Homo sapiens_hsa054160.42242180
95Notch signaling pathway_Homo sapiens_hsa043300.41438419
96Pyruvate metabolism_Homo sapiens_hsa006200.41331101
97Measles_Homo sapiens_hsa051620.41267378
98Wnt signaling pathway_Homo sapiens_hsa043100.40464589
99Colorectal cancer_Homo sapiens_hsa052100.40170178
100Shigellosis_Homo sapiens_hsa051310.39529027
101HIF-1 signaling pathway_Homo sapiens_hsa040660.37377428
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37213354
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36785622
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36488219
105Other glycan degradation_Homo sapiens_hsa005110.35319395
106Choline metabolism in cancer_Homo sapiens_hsa052310.35208713
107Hepatitis B_Homo sapiens_hsa051610.34299464
108AMPK signaling pathway_Homo sapiens_hsa041520.34084565
109Inositol phosphate metabolism_Homo sapiens_hsa005620.33694440
110Prolactin signaling pathway_Homo sapiens_hsa049170.31751023
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.31619871
112Pathways in cancer_Homo sapiens_hsa052000.31221538
113Acute myeloid leukemia_Homo sapiens_hsa052210.29254258
114Vitamin B6 metabolism_Homo sapiens_hsa007500.29004006
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.28946903
116Tight junction_Homo sapiens_hsa045300.28410117
117Hematopoietic cell lineage_Homo sapiens_hsa046400.27671112
118Hedgehog signaling pathway_Homo sapiens_hsa043400.27559912
119Toxoplasmosis_Homo sapiens_hsa051450.27393216
120Proteoglycans in cancer_Homo sapiens_hsa052050.27337260
121Folate biosynthesis_Homo sapiens_hsa007900.23285116
122Fructose and mannose metabolism_Homo sapiens_hsa000510.23228650
123Influenza A_Homo sapiens_hsa051640.20866546
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20198395
125Non-small cell lung cancer_Homo sapiens_hsa052230.19119062
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.18535717
127Prostate cancer_Homo sapiens_hsa052150.17891411
128T cell receptor signaling pathway_Homo sapiens_hsa046600.17608105
129B cell receptor signaling pathway_Homo sapiens_hsa046620.17044745
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.16852057
131ECM-receptor interaction_Homo sapiens_hsa045120.16519478

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