RPL3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.45923026
2SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.10514668
3translational elongation (GO:0006414)9.06864191
4cotranslational protein targeting to membrane (GO:0006613)8.98385379
5protein targeting to ER (GO:0045047)8.95173485
6establishment of protein localization to endoplasmic reticulum (GO:0072599)8.57550626
7maturation of SSU-rRNA (GO:0030490)8.44898742
8protein localization to endoplasmic reticulum (GO:0070972)8.40760368
9cellular protein complex disassembly (GO:0043624)8.35346433
10viral life cycle (GO:0019058)8.24195605
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.99994152
12protein complex disassembly (GO:0043241)7.09623759
13translational initiation (GO:0006413)6.99476463
14macromolecular complex disassembly (GO:0032984)6.65456709
15chaperone-mediated protein transport (GO:0072321)6.55131827
16ATP synthesis coupled proton transport (GO:0015986)6.34153468
17energy coupled proton transport, down electrochemical gradient (GO:0015985)6.34153468
18protein targeting to membrane (GO:0006612)6.09093547
19ribosomal large subunit biogenesis (GO:0042273)5.93179602
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.93070103
21translation (GO:0006412)5.41259524
22nuclear-transcribed mRNA catabolic process (GO:0000956)5.36527576
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.21783179
24mRNA catabolic process (GO:0006402)5.05952991
25ribonucleoprotein complex biogenesis (GO:0022613)4.85990187
26respiratory electron transport chain (GO:0022904)4.77680493
27protein complex biogenesis (GO:0070271)4.76113528
28electron transport chain (GO:0022900)4.70630339
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.66891817
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.66891817
31NADH dehydrogenase complex assembly (GO:0010257)4.66891817
32cellular component biogenesis (GO:0044085)4.61230099
33RNA catabolic process (GO:0006401)4.55168535
34establishment of protein localization to mitochondrial membrane (GO:0090151)4.44643287
35mitochondrial respiratory chain complex assembly (GO:0033108)4.40981314
36behavioral response to nicotine (GO:0035095)4.21785134
37protein neddylation (GO:0045116)4.19147295
38establishment of protein localization to membrane (GO:0090150)4.17618804
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.08459818
40protein targeting (GO:0006605)3.94231639
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.86163682
42substrate-independent telencephalic tangential migration (GO:0021826)3.86163682
43establishment of protein localization to organelle (GO:0072594)3.66081183
44ATP biosynthetic process (GO:0006754)3.63178945
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.55409588
46ncRNA 3-end processing (GO:0043628)3.49911512
47pyrimidine nucleotide catabolic process (GO:0006244)3.49844338
48purine nucleoside triphosphate biosynthetic process (GO:0009145)3.49025935
49rRNA processing (GO:0006364)3.38710873
50hydrogen ion transmembrane transport (GO:1902600)3.33721406
51GTP biosynthetic process (GO:0006183)3.30806625
52protein localization to membrane (GO:0072657)3.30756653
53rRNA metabolic process (GO:0016072)3.29597561
54ribonucleoside triphosphate biosynthetic process (GO:0009201)3.24051210
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09235032
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09235032
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05886729
58positive regulation of respiratory burst (GO:0060267)2.93658395
59cytochrome complex assembly (GO:0017004)2.92227581
60UTP biosynthetic process (GO:0006228)2.91302850
61cell proliferation in forebrain (GO:0021846)2.89452123
62protein-cofactor linkage (GO:0018065)2.84469896
63protein targeting to mitochondrion (GO:0006626)2.83699472
64proton transport (GO:0015992)2.82990689
65base-excision repair, AP site formation (GO:0006285)2.78790248
66hydrogen transport (GO:0006818)2.76010315
67DNA deamination (GO:0045006)2.75030528
68establishment of protein localization to mitochondrion (GO:0072655)2.73211374
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72823750
70nucleoside triphosphate biosynthetic process (GO:0009142)2.72605753
71UTP metabolic process (GO:0046051)2.70691307
72termination of RNA polymerase III transcription (GO:0006386)2.70231889
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.70231889
74cardiovascular system development (GO:0072358)2.69673088
75water-soluble vitamin biosynthetic process (GO:0042364)2.69521117
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68439558
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68169899
78regulation of mitochondrial translation (GO:0070129)2.66962677
79CTP metabolic process (GO:0046036)2.66400606
80CTP biosynthetic process (GO:0006241)2.66400606
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65615373
82respiratory chain complex IV assembly (GO:0008535)2.63787827
83protein localization to organelle (GO:0033365)2.63675694
84intracellular protein transmembrane import (GO:0044743)2.62071450
85pseudouridine synthesis (GO:0001522)2.59121957
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55229396
87nonmotile primary cilium assembly (GO:0035058)2.54049896
88deoxyribonucleotide catabolic process (GO:0009264)2.53389293
89positive regulation of T cell apoptotic process (GO:0070234)2.50371669
90protein localization to mitochondrion (GO:0070585)2.46004521
91parturition (GO:0007567)2.43310336
92RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.42985941
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.41642321
94pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41448214
95pattern specification involved in kidney development (GO:0061004)2.41029213
96negative regulation of response to food (GO:0032096)2.36308357
97negative regulation of appetite (GO:0032099)2.36308357
98ribosomal small subunit biogenesis (GO:0042274)11.5425474
99viral transcription (GO:0019083)11.4437069
100translational termination (GO:0006415)10.9273727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77731573
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.53948834
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43281271
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.45773908
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09620304
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.07578042
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.00988279
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79735045
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78979469
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75927926
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43962764
12CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.37752468
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35860171
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24272795
15XRN2_22483619_ChIP-Seq_HELA_Human2.24131675
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18687547
17TTF2_22483619_ChIP-Seq_HELA_Human1.98639705
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98056546
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95770828
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91175349
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89528328
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82466078
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79476292
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73651736
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70526986
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.69481939
27MYC_18940864_ChIP-ChIP_HL60_Human1.58047254
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.57763814
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.55652104
30VDR_23849224_ChIP-Seq_CD4+_Human1.54796245
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53939921
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.49520800
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49057745
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48751885
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48440220
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48345229
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47526801
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.47247334
39CTCF_18555785_ChIP-Seq_MESCs_Mouse1.46346923
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.45400019
41FOXP3_21729870_ChIP-Seq_TREG_Human1.42724999
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42233162
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41764163
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39745752
45GABP_19822575_ChIP-Seq_HepG2_Human1.37896087
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37349491
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36835278
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35934117
49IRF1_19129219_ChIP-ChIP_H3396_Human1.34510208
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.32878568
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32166507
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.29508481
53VDR_22108803_ChIP-Seq_LS180_Human1.27065887
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24130531
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23999904
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.20635743
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20202250
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.19823895
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18222109
60CTCF_20526341_ChIP-Seq_ESCs_Human1.18068086
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.17972964
62ELK1_19687146_ChIP-ChIP_HELA_Human1.16609528
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16548636
64TAF2_19829295_ChIP-Seq_ESCs_Human1.16298590
65ERA_21632823_ChIP-Seq_H3396_Human1.14649260
66CTCF_27219007_Chip-Seq_Bcells_Human1.14605052
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14474021
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13035435
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12806984
70REST_21632747_ChIP-Seq_MESCs_Mouse1.12116396
71NANOG_20526341_ChIP-Seq_ESCs_Human1.10851110
72ZNF274_21170338_ChIP-Seq_K562_Hela1.10837925
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10755361
74TP53_22573176_ChIP-Seq_HFKS_Human1.10282943
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08134137
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08134137
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.07169168
78STAT1_20625510_ChIP-Seq_HELA_Human1.07102348
79SA1_27219007_Chip-Seq_Bcells_Human1.06290605
80RNF2_27304074_Chip-Seq_NSC_Mouse1.05792526
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05407135
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05360223
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04851250
84BCL6_27268052_Chip-Seq_Bcells_Human1.04417597
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.03732647
86NCOR_22424771_ChIP-Seq_293T_Human1.01226179
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.00329729
88P68_20966046_ChIP-Seq_HELA_Human0.99980355
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98669490
90VDR_21846776_ChIP-Seq_THP-1_Human0.98137566
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97991318
92P53_21459846_ChIP-Seq_SAOS-2_Human0.97958737
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97491997
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97216913
95E2F1_20622854_ChIP-Seq_HELA_Human0.95755224
96CTCF_26484167_Chip-Seq_Bcells_Mouse0.95146850
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90348282
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.87749310
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86403229
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86224616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.69817070
2MP0006292_abnormal_olfactory_placode4.91915863
3MP0003123_paternal_imprinting3.12008764
4MP0002163_abnormal_gland_morphology2.99144252
5MP0003787_abnormal_imprinting2.72022300
6MP0002638_abnormal_pupillary_reflex2.40510787
7MP0008789_abnormal_olfactory_epithelium2.12568775
8MP0004142_abnormal_muscle_tone1.96579023
9MP0002837_dystrophic_cardiac_calcinosis1.85776429
10MP0003121_genomic_imprinting1.84618048
11MP0002938_white_spotting1.83049644
12MP0002653_abnormal_ependyma_morphology1.77190010
13MP0002160_abnormal_reproductive_system1.77054154
14MP0005394_taste/olfaction_phenotype1.75689428
15MP0005499_abnormal_olfactory_system1.75689428
16MP0000049_abnormal_middle_ear1.74094771
17MP0003122_maternal_imprinting1.70391726
18MP0004885_abnormal_endolymph1.68924991
19MP0003646_muscle_fatigue1.67682733
20MP0003878_abnormal_ear_physiology1.62861628
21MP0005377_hearing/vestibular/ear_phenot1.62861628
22MP0005379_endocrine/exocrine_gland_phen1.62025398
23MP0002095_abnormal_skin_pigmentation1.60176544
24MP0001905_abnormal_dopamine_level1.57557097
25MP0003186_abnormal_redox_activity1.54141290
26MP0005389_reproductive_system_phenotype1.49360796
27MP0005646_abnormal_pituitary_gland1.47081157
28MP0006072_abnormal_retinal_apoptosis1.45707209
29MP0005174_abnormal_tail_pigmentation1.44387762
30MP0000631_abnormal_neuroendocrine_gland1.39954110
31MP0006276_abnormal_autonomic_nervous1.37762672
32MP0001485_abnormal_pinna_reflex1.35358465
33MP0008877_abnormal_DNA_methylation1.35243877
34MP0005551_abnormal_eye_electrophysiolog1.34646615
35MP0001968_abnormal_touch/_nociception1.33217901
36MP0003136_yellow_coat_color1.30071482
37MP0002876_abnormal_thyroid_physiology1.27703694
38MP0002277_abnormal_respiratory_mucosa1.25178174
39MP0000778_abnormal_nervous_system1.21090620
40MP0003879_abnormal_hair_cell1.20176246
41MP0004145_abnormal_muscle_electrophysio1.20026139
42MP0001293_anophthalmia1.17611405
43MP0004742_abnormal_vestibular_system1.16220031
44MP0003011_delayed_dark_adaptation1.14323521
45MP0004133_heterotaxia1.13005883
46MP0002272_abnormal_nervous_system1.12240576
47MP0001919_abnormal_reproductive_system1.11954294
48MP0005195_abnormal_posterior_eye1.11501288
49MP0003880_abnormal_central_pattern1.11061273
50MP0009745_abnormal_behavioral_response1.08550898
51MP0003806_abnormal_nucleotide_metabolis1.07885641
52MP0000566_synostosis1.06315702
53MP0001529_abnormal_vocalization1.06105218
54MP0008875_abnormal_xenobiotic_pharmacok1.05779068
55MP0000026_abnormal_inner_ear1.05356592
56MP0002557_abnormal_social/conspecific_i1.05299923
57MP0001986_abnormal_taste_sensitivity1.05137319
58MP0003938_abnormal_ear_development1.04764939
59MP0002822_catalepsy0.99183721
60MP0001188_hyperpigmentation0.97399853
61MP0000372_irregular_coat_pigmentation0.96630017
62MP0002752_abnormal_somatic_nervous0.96522093
63MP0009046_muscle_twitch0.96117367
64MP0010030_abnormal_orbit_morphology0.94608917
65MP0000678_abnormal_parathyroid_gland0.94122601
66MP0001440_abnormal_grooming_behavior0.93303868
67MP0005084_abnormal_gallbladder_morpholo0.91829135
68MP0006036_abnormal_mitochondrial_physio0.90497634
69MP0002736_abnormal_nociception_after0.89878268
70MP0001502_abnormal_circadian_rhythm0.87085690
71MP0005423_abnormal_somatic_nervous0.86892262
72MP0002234_abnormal_pharynx_morphology0.85679564
73MP0001963_abnormal_hearing_physiology0.84165293
74MP0002184_abnormal_innervation0.82879982
75MP0001970_abnormal_pain_threshold0.81403801
76MP0008872_abnormal_physiological_respon0.80671113
77MP0002210_abnormal_sex_determination0.80184110
78MP0001663_abnormal_digestive_system0.80124105
79MP0008995_early_reproductive_senescence0.77926085
80MP0000955_abnormal_spinal_cord0.75947688
81MP0002572_abnormal_emotion/affect_behav0.74293072
82MP0002733_abnormal_thermal_nociception0.74118187
83MP0005645_abnormal_hypothalamus_physiol0.73615104
84MP0002735_abnormal_chemical_nociception0.71546652
85MP0002064_seizures0.69616193
86MP0004147_increased_porphyrin_level0.67844546
87MP0009053_abnormal_anal_canal0.67480047
88MP0002067_abnormal_sensory_capabilities0.67166092
89MP0003942_abnormal_urinary_system0.65845762
90MP0002063_abnormal_learning/memory/cond0.64210817
91MP0000015_abnormal_ear_pigmentation0.62820516
92MP0002882_abnormal_neuron_morphology0.62521314
93MP0009250_abnormal_appendicular_skeleto0.62113870
94MP0003635_abnormal_synaptic_transmissio0.61813396
95MP0002102_abnormal_ear_morphology0.61284931
96MP0001944_abnormal_pancreas_morphology0.60248278
97MP0004858_abnormal_nervous_system0.60186445
98MP0001873_stomach_inflammation0.59970972
99MP0004043_abnormal_pH_regulation0.59627743
100MP0005253_abnormal_eye_physiology0.59178993

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.60282931
2Reticulocytopenia (HP:0001896)6.20268792
3Abnormal number of erythroid precursors (HP:0012131)5.49096924
4Macrocytic anemia (HP:0001972)5.46805496
5Acute necrotizing encephalopathy (HP:0006965)5.19984084
6Abnormal mitochondria in muscle tissue (HP:0008316)4.74949523
7Pallor (HP:0000980)4.60834521
8Mitochondrial inheritance (HP:0001427)4.59887623
9Acute encephalopathy (HP:0006846)4.36950547
10Progressive macrocephaly (HP:0004481)4.18824361
11Increased hepatocellular lipid droplets (HP:0006565)4.06298526
12Increased CSF lactate (HP:0002490)3.93956121
13Lipid accumulation in hepatocytes (HP:0006561)3.79919121
14Renal Fanconi syndrome (HP:0001994)3.77191309
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.49202046
16Increased intramyocellular lipid droplets (HP:0012240)3.47704637
17Molar tooth sign on MRI (HP:0002419)3.47484949
18Abnormality of midbrain morphology (HP:0002418)3.47484949
193-Methylglutaconic aciduria (HP:0003535)3.38069793
20Hepatocellular necrosis (HP:0001404)3.31507221
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20905935
22Cerebral edema (HP:0002181)3.17224534
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04249682
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04249682
25Hepatic necrosis (HP:0002605)3.03631571
26Increased muscle lipid content (HP:0009058)2.99126521
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96574262
28Myokymia (HP:0002411)2.94157092
29Pancreatic fibrosis (HP:0100732)2.93942345
30Septo-optic dysplasia (HP:0100842)2.82643866
31Absent thumb (HP:0009777)2.79002123
32Exertional dyspnea (HP:0002875)2.75960081
33Abnormality of renal resorption (HP:0011038)2.73592817
34Abnormal rod and cone electroretinograms (HP:0008323)2.69179631
35Pancreatic cysts (HP:0001737)2.67780234
36Stenosis of the external auditory canal (HP:0000402)2.64468977
37Rib fusion (HP:0000902)2.63805507
38Abnormal hemoglobin (HP:0011902)2.57266378
39Type II lissencephaly (HP:0007260)2.47796209
40Optic disc pallor (HP:0000543)2.45292295
41Congenital stationary night blindness (HP:0007642)2.43948335
42Depressed nasal ridge (HP:0000457)2.40772755
43Hyperthyroidism (HP:0000836)2.36197275
44Lactic acidosis (HP:0003128)2.34975810
45Hyperglycinemia (HP:0002154)2.32257773
46Hypoplasia of the radius (HP:0002984)2.32171803
47Respiratory failure (HP:0002878)2.31672585
48Respiratory difficulties (HP:0002880)2.30017805
49Increased serum lactate (HP:0002151)2.27117937
50Glycosuria (HP:0003076)2.25175354
51Abnormality of urine glucose concentration (HP:0011016)2.25175354
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18877894
53Exercise intolerance (HP:0003546)2.18722587
54Medial flaring of the eyebrow (HP:0010747)2.16688544
55True hermaphroditism (HP:0010459)2.13979650
56Nephronophthisis (HP:0000090)2.13416510
57Hyperphosphaturia (HP:0003109)2.12842877
58Leukodystrophy (HP:0002415)2.12429989
59Partial duplication of thumb phalanx (HP:0009944)2.07962276
60Pendular nystagmus (HP:0012043)2.07577220
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.02945712
62Partial duplication of the phalanx of hand (HP:0009999)1.98684650
63Asplenia (HP:0001746)1.98485803
64Microretrognathia (HP:0000308)1.97562788
65Abnormal drinking behavior (HP:0030082)1.95357530
66Polydipsia (HP:0001959)1.95357530
67Anencephaly (HP:0002323)1.90851469
68Sclerocornea (HP:0000647)1.88737877
69Abnormality of the renal medulla (HP:0100957)1.84787592
70Lethargy (HP:0001254)1.81728707
71Forearm undergrowth (HP:0009821)1.81704756
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.80299551
73Absent/shortened dynein arms (HP:0200106)1.80299551
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79319470
75Cystic liver disease (HP:0006706)1.78655194
76Triphalangeal thumb (HP:0001199)1.76959735
77Abnormal respiratory motile cilium morphology (HP:0005938)1.76370479
78Abnormal respiratory epithelium morphology (HP:0012253)1.76370479
79Abnormal urine phosphate concentration (HP:0012599)1.76357775
80Colon cancer (HP:0003003)1.75606346
81Maternal diabetes (HP:0009800)1.74248372
82Gait imbalance (HP:0002141)1.73525900
8311 pairs of ribs (HP:0000878)1.71929865
84Concave nail (HP:0001598)1.71376905
85Thick lower lip vermilion (HP:0000179)1.67215244
86Short femoral neck (HP:0100864)1.66680655
87Adrenal hypoplasia (HP:0000835)1.65784827
88Abnormality of reticulocytes (HP:0004312)1.65212611
89Abolished electroretinogram (ERG) (HP:0000550)1.64535361
90Congenital primary aphakia (HP:0007707)1.64374796
91Hypoplasia of the ulna (HP:0003022)1.63520062
92Symphalangism affecting the phalanges of the hand (HP:0009773)1.62957449
93Abnormality of the renal cortex (HP:0011035)1.62360013
94Optic nerve hypoplasia (HP:0000609)1.62123917
95Anophthalmia (HP:0000528)1.60746969
96Cleft eyelid (HP:0000625)1.59068816
97Congenital, generalized hypertrichosis (HP:0004540)1.57237645
98X-linked dominant inheritance (HP:0001423)1.56495976
99Polyuria (HP:0000103)1.56313672
100Patent foramen ovale (HP:0001655)1.56267117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.35352651
2STK163.62014934
3TLK12.70109505
4WNK42.52093882
5BCKDK2.17622637
6CDK192.15933336
7ADRBK22.10250363
8DYRK22.08518831
9LRRK22.07351409
10CDC71.99757182
11EPHB21.88248785
12GRK11.88177945
13ABL21.80771878
14MAP3K111.66478465
15ARAF1.61737941
16CAMKK21.57245061
17BRAF1.56078493
18ZAK1.45630025
19BMPR1B1.38641067
20PIK3CA1.35654035
21CAMK11.25713170
22PINK11.25642244
23NTRK21.25410311
24VRK21.22775180
25INSRR1.20857158
26PIM21.20293015
27CASK1.19781419
28LIMK11.18888209
29PRKCG1.18380411
30NUAK11.14974616
31CAMK1D1.11923642
32ADRBK11.09164732
33AURKA1.08661756
34FRK1.07406679
35NME11.07005573
36WNK31.06781044
37STK111.03353969
38TXK1.02625099
39DMPK1.01698571
40RPS6KA60.99254363
41NEK20.98453577
42TIE10.95912564
43CSNK2A20.95867229
44EPHA40.94108447
45PLK40.93892150
46DAPK30.88663093
47GRK70.85605103
48MAPK150.84483030
49RPS6KB20.83536882
50CAMKK10.82856582
51STK390.82106431
52RPS6KL10.81065383
53RPS6KC10.81065383
54TYRO30.79305572
55RPS6KA50.79140314
56MAP4K20.78693681
57PIM10.78305447
58PASK0.77644565
59PRKCI0.76504063
60PRKACA0.75155120
61MAP3K90.72914543
62AURKB0.71980073
63CHEK20.71368821
64MARK30.70150165
65IKBKB0.69588399
66CSNK2A10.69585020
67CSNK1E0.69231464
68CAMK1G0.67026845
69PDK20.66000357
70MAP2K60.65831144
71ILK0.65796688
72PRKCQ0.65773017
73NTRK30.65185236
74WNK10.62165344
75PRKCH0.59886555
76SGK2230.58952744
77SGK4940.58952744
78MAP3K40.58919889
79MINK10.58010656
80VRK10.57722205
81PLK10.55263711
82PRKCZ0.53657712
83TEC0.53250467
84DYRK30.52806844
85PRKCD0.52476354
86TGFBR10.51170576
87PKN10.49939590
88OXSR10.49909398
89PRKCA0.49704938
90MAP4K10.49263209
91OBSCN0.48043564
92MAPK130.47098224
93CDK80.46821094
94PAK30.46543062
95DYRK1B0.44431884
96CSNK1A10.44385714
97KIT0.42967822
98SGK10.42904335
99TAOK30.42436551
100MAP2K20.41367890

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030109.07979720
2Oxidative phosphorylation_Homo sapiens_hsa001905.15503711
3Parkinsons disease_Homo sapiens_hsa050124.24247272
4Huntingtons disease_Homo sapiens_hsa050163.07116391
5Alzheimers disease_Homo sapiens_hsa050102.96740448
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.95257568
7Cardiac muscle contraction_Homo sapiens_hsa042602.73824358
8Sulfur relay system_Homo sapiens_hsa041222.38270738
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19140706
10RNA polymerase_Homo sapiens_hsa030202.18671691
11Protein export_Homo sapiens_hsa030601.62394145
12Linoleic acid metabolism_Homo sapiens_hsa005911.52041316
13Pyrimidine metabolism_Homo sapiens_hsa002401.43108623
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41979269
15Homologous recombination_Homo sapiens_hsa034401.38263756
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38144572
17Proteasome_Homo sapiens_hsa030501.16170773
18DNA replication_Homo sapiens_hsa030301.09134933
19Phototransduction_Homo sapiens_hsa047441.08012977
20Fanconi anemia pathway_Homo sapiens_hsa034601.06104104
21Nucleotide excision repair_Homo sapiens_hsa034201.02665565
22Folate biosynthesis_Homo sapiens_hsa007901.01497750
23RNA degradation_Homo sapiens_hsa030181.00995738
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97352994
25Basal transcription factors_Homo sapiens_hsa030220.95572066
26Arachidonic acid metabolism_Homo sapiens_hsa005900.93179172
27Asthma_Homo sapiens_hsa053100.89393744
28One carbon pool by folate_Homo sapiens_hsa006700.86803119
29Maturity onset diabetes of the young_Homo sapiens_hsa049500.86347969
30Collecting duct acid secretion_Homo sapiens_hsa049660.85740682
31Base excision repair_Homo sapiens_hsa034100.84444208
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82777323
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80795965
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78443488
35Intestinal immune network for IgA production_Homo sapiens_hsa046720.76851487
36Ether lipid metabolism_Homo sapiens_hsa005650.76823364
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76174564
38Sulfur metabolism_Homo sapiens_hsa009200.75913463
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75664372
40Chemical carcinogenesis_Homo sapiens_hsa052040.75546270
41Nicotine addiction_Homo sapiens_hsa050330.75234163
42Metabolic pathways_Homo sapiens_hsa011000.74749429
43Fat digestion and absorption_Homo sapiens_hsa049750.73604584
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72941835
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72917318
46Mismatch repair_Homo sapiens_hsa034300.71639727
47Purine metabolism_Homo sapiens_hsa002300.70063958
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.69798588
49Caffeine metabolism_Homo sapiens_hsa002320.68867030
50Peroxisome_Homo sapiens_hsa041460.67449914
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.67393719
52Tryptophan metabolism_Homo sapiens_hsa003800.65704152
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64360694
54Spliceosome_Homo sapiens_hsa030400.64203205
55Retinol metabolism_Homo sapiens_hsa008300.64138440
56Butanoate metabolism_Homo sapiens_hsa006500.63871584
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61810565
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56948973
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56839351
60Olfactory transduction_Homo sapiens_hsa047400.56412945
61Regulation of autophagy_Homo sapiens_hsa041400.50279078
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49494446
63Mineral absorption_Homo sapiens_hsa049780.49048096
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48429199
65Nitrogen metabolism_Homo sapiens_hsa009100.47089153
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46589449
67Morphine addiction_Homo sapiens_hsa050320.39474086
68Glutathione metabolism_Homo sapiens_hsa004800.38064763
69Tyrosine metabolism_Homo sapiens_hsa003500.37055040
70Rheumatoid arthritis_Homo sapiens_hsa053230.35979099
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35456262
72Allograft rejection_Homo sapiens_hsa053300.35452773
73RNA transport_Homo sapiens_hsa030130.32801517
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31838361
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31118364
76Autoimmune thyroid disease_Homo sapiens_hsa053200.30786573
77Insulin secretion_Homo sapiens_hsa049110.30622745
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29542176
79Basal cell carcinoma_Homo sapiens_hsa052170.28771581
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.28243329
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27985085
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26924651
83Type I diabetes mellitus_Homo sapiens_hsa049400.26233855
84Fatty acid degradation_Homo sapiens_hsa000710.26043871
85Systemic lupus erythematosus_Homo sapiens_hsa053220.25515767
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25064407
87Primary immunodeficiency_Homo sapiens_hsa053400.24601038
88Hedgehog signaling pathway_Homo sapiens_hsa043400.23634249
89Synaptic vesicle cycle_Homo sapiens_hsa047210.23200503
90Graft-versus-host disease_Homo sapiens_hsa053320.23050044
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22057209
92beta-Alanine metabolism_Homo sapiens_hsa004100.21942989
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.21635773
94Glycerolipid metabolism_Homo sapiens_hsa005610.20591545
95Selenocompound metabolism_Homo sapiens_hsa004500.18915041
96Serotonergic synapse_Homo sapiens_hsa047260.18461625
97Ovarian steroidogenesis_Homo sapiens_hsa049130.18230344
98Notch signaling pathway_Homo sapiens_hsa043300.17864405
99Arginine and proline metabolism_Homo sapiens_hsa003300.14670989
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12832594

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