RPL39P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.94769400
2ribosomal small subunit assembly (GO:0000028)9.17815991
3viral transcription (GO:0019083)9.09125482
4translational termination (GO:0006415)8.67777323
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.95425806
6ATP synthesis coupled proton transport (GO:0015986)7.95425806
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.91566187
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.43439281
9protein targeting to ER (GO:0045047)7.37293563
10cotranslational protein targeting to membrane (GO:0006613)7.33893446
11translational elongation (GO:0006414)7.21811056
12establishment of protein localization to endoplasmic reticulum (GO:0072599)7.03447485
13protein localization to endoplasmic reticulum (GO:0070972)7.00780968
14maturation of SSU-rRNA (GO:0030490)6.83613493
15respiratory chain complex IV assembly (GO:0008535)6.64116328
16cellular protein complex disassembly (GO:0043624)6.63972810
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.41421234
18viral life cycle (GO:0019058)6.16241916
19regulation of female gonad development (GO:2000194)5.80511341
20translational initiation (GO:0006413)5.76962302
21protein complex disassembly (GO:0043241)5.71996557
22innate immune response in mucosa (GO:0002227)5.70132296
23protein complex biogenesis (GO:0070271)5.50330836
24chaperone-mediated protein transport (GO:0072321)5.48833681
25macromolecular complex disassembly (GO:0032984)5.42938710
26cytochrome complex assembly (GO:0017004)5.39238653
27tyrosine phosphorylation of STAT protein (GO:0007260)5.01446538
28protein targeting to membrane (GO:0006612)4.96667948
29mitochondrial respiratory chain complex assembly (GO:0033108)4.83147309
30respiratory electron transport chain (GO:0022904)4.72030777
31mucosal immune response (GO:0002385)4.68927024
32ribosomal large subunit biogenesis (GO:0042273)4.65435631
33electron transport chain (GO:0022900)4.58111697
34ovulation cycle (GO:0042698)4.56235582
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.55561269
36antibacterial humoral response (GO:0019731)4.47415800
37translation (GO:0006412)4.46955464
38base-excision repair, AP site formation (GO:0006285)4.43464690
39protein neddylation (GO:0045116)4.36465796
40nuclear-transcribed mRNA catabolic process (GO:0000956)4.34198619
41white fat cell differentiation (GO:0050872)4.22529762
42organ or tissue specific immune response (GO:0002251)4.18933108
43ATP biosynthetic process (GO:0006754)4.16381079
44mRNA catabolic process (GO:0006402)4.14593375
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09745301
46mitochondrial respiratory chain complex I assembly (GO:0032981)4.09745301
47NADH dehydrogenase complex assembly (GO:0010257)4.09745301
48DNA replication-dependent nucleosome assembly (GO:0006335)4.05370466
49DNA replication-dependent nucleosome organization (GO:0034723)4.05370466
50hypothalamus development (GO:0021854)4.04332955
51peptidyl-histidine modification (GO:0018202)4.02754110
52myeloid cell homeostasis (GO:0002262)3.97606449
53antimicrobial humoral response (GO:0019730)3.95349400
54hydrogen ion transmembrane transport (GO:1902600)3.95020551
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93124236
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.86537382
57cellular component biogenesis (GO:0044085)3.84217939
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.79874392
59ubiquinone biosynthetic process (GO:0006744)3.74852626
60termination of RNA polymerase III transcription (GO:0006386)3.74204097
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.74204097
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.69331551
63RNA catabolic process (GO:0006401)3.67029688
64ribonucleoprotein complex biogenesis (GO:0022613)3.56673282
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.41489336
66protein targeting (GO:0006605)3.39023531
67regulation of transmission of nerve impulse (GO:0051969)3.35108362
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.33949621
69establishment of protein localization to membrane (GO:0090150)3.33762828
70proton transport (GO:0015992)3.32488949
71establishment of protein localization to organelle (GO:0072594)3.27968470
72response to pheromone (GO:0019236)3.27864016
73GDP-mannose metabolic process (GO:0019673)3.24635512
74ubiquinone metabolic process (GO:0006743)3.22470731
75hydrogen transport (GO:0006818)3.22260439
76protein targeting to mitochondrion (GO:0006626)3.20999984
77regulation of mitochondrial translation (GO:0070129)3.18983129
78establishment of protein localization to mitochondrion (GO:0072655)3.16414096
79autophagic vacuole fusion (GO:0000046)3.14976128
80negative regulation of catenin import into nucleus (GO:0035414)3.10901996
81regulation of bile acid biosynthetic process (GO:0070857)3.04142117
82cell aggregation (GO:0098743)3.01457501
83cartilage condensation (GO:0001502)3.01457501
84positive regulation of fatty acid oxidation (GO:0046321)3.00330684
85protein localization to mitochondrion (GO:0070585)2.97635441
86quinone biosynthetic process (GO:1901663)2.93460866
87mitochondrial transport (GO:0006839)2.93084807
88appendage development (GO:0048736)2.90119252
89limb development (GO:0060173)2.90119252
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90057317
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90057317
92pyrimidine nucleotide catabolic process (GO:0006244)2.86863797
93endocrine hormone secretion (GO:0060986)2.83454472
94cellular response to lithium ion (GO:0071285)2.79269712
95extracellular fibril organization (GO:0043206)2.75412912
96organelle disassembly (GO:1903008)2.73590774
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73009360
98substrate-independent telencephalic tangential migration (GO:0021826)2.73009360
99nucleoside triphosphate biosynthetic process (GO:0009142)2.71584117
100brown fat cell differentiation (GO:0050873)2.68493426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.52151650
2EZH2_22144423_ChIP-Seq_EOC_Human3.93971348
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23551835
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.21837503
5ETS1_20019798_ChIP-Seq_JURKAT_Human2.79830500
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69534404
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57116249
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48310986
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43712890
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.40680507
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18648806
12VDR_23849224_ChIP-Seq_CD4+_Human2.16378550
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.00457634
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.8867596
15CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.90547066
16THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83346276
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80895400
18ELK1_19687146_ChIP-ChIP_HELA_Human1.75713036
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.72606728
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71568033
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.70109658
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69198853
23TTF2_22483619_ChIP-Seq_HELA_Human1.67836634
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65744738
25IRF1_19129219_ChIP-ChIP_H3396_Human1.64723960
26XRN2_22483619_ChIP-Seq_HELA_Human1.63869668
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58436715
28FOXP3_21729870_ChIP-Seq_TREG_Human1.54581501
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53580645
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48428938
31CIITA_25753668_ChIP-Seq_RAJI_Human1.42113192
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39091924
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36388450
34ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34583938
35GABP_19822575_ChIP-Seq_HepG2_Human1.30422343
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30062102
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28817311
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27770955
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27181618
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25953237
41TP53_22573176_ChIP-Seq_HFKS_Human1.18975281
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18858042
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16647650
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15685925
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.14262544
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12920057
47AR_21572438_ChIP-Seq_LNCaP_Human1.09657576
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09463403
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09367282
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.09332499
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09046900
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06714665
53KDM5A_27292631_Chip-Seq_BREAST_Human1.05975791
54MYC_18940864_ChIP-ChIP_HL60_Human1.05637945
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05030842
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04933080
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.02644127
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02409029
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00039858
60HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97846530
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96299837
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96258514
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95222940
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94944019
65E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93462471
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93223166
67TP53_22127205_ChIP-Seq_IMR90_Human0.92410681
68NOTCH1_21737748_ChIP-Seq_TLL_Human0.89084043
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87952181
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84253773
71BP1_19119308_ChIP-ChIP_Hs578T_Human0.82211357
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80469473
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80225053
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79891407
75CTCF_18555785_ChIP-Seq_MESCs_Mouse0.79885988
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.76602650
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76577079
78E2F1_20622854_ChIP-Seq_HELA_Human0.76021935
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74421932
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73935033
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.73863664
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73624280
83TAF2_19829295_ChIP-Seq_ESCs_Human0.72628353
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72034037
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71165104
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70933500
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70852731
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.70786273
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.69947181
90TET1_21451524_ChIP-Seq_MESCs_Mouse0.68807924
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68320230
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.66789810
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.66774629
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.65735691
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65670012
96P68_20966046_ChIP-Seq_HELA_Human0.65406791
97STAT1_20625510_ChIP-Seq_HELA_Human0.65053016
98E2F1_18555785_ChIP-Seq_MESCs_Mouse0.64837255
99ZNF274_21170338_ChIP-Seq_K562_Hela0.64668218
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63311557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.51475853
2MP0003646_muscle_fatigue5.32601306
3MP0003315_abnormal_perineum_morphology4.24668936
4MP0005503_abnormal_tendon_morphology4.02664059
5MP0002163_abnormal_gland_morphology3.70775393
6MP0001348_abnormal_lacrimal_gland3.68808201
7MP0004185_abnormal_adipocyte_glucose3.56576070
8MP0008438_abnormal_cutaneous_collagen3.49755744
9MP0005646_abnormal_pituitary_gland3.27857052
10MP0004130_abnormal_muscle_cell3.24916140
11MP0003279_aneurysm3.11546867
12MP0005083_abnormal_biliary_tract3.08039618
13MP0005187_abnormal_penis_morphology3.00223206
14MP0005379_endocrine/exocrine_gland_phen2.33616428
15MP0005670_abnormal_white_adipose2.16154712
16MP0000751_myopathy2.12743191
17MP0003011_delayed_dark_adaptation2.07103030
18MP0004145_abnormal_muscle_electrophysio1.99954056
19MP0002108_abnormal_muscle_morphology1.87656728
20MP0008995_early_reproductive_senescence1.84320689
21MP0002876_abnormal_thyroid_physiology1.81386275
22MP0005666_abnormal_adipose_tissue1.66014166
23MP0003186_abnormal_redox_activity1.64831824
24MP0001661_extended_life_span1.64212174
25MP0005275_abnormal_skin_tensile1.57707587
26MP0002160_abnormal_reproductive_system1.56857307
27MP0002282_abnormal_trachea_morphology1.53001976
28MP0001542_abnormal_bone_strength1.51229773
29MP0003787_abnormal_imprinting1.48278431
30MP0008789_abnormal_olfactory_epithelium1.42308212
31MP0001958_emphysema1.28451465
32MP0009250_abnormal_appendicular_skeleto1.28265347
33MP0002277_abnormal_respiratory_mucosa1.26470691
34MP0005375_adipose_tissue_phenotype1.18966520
35MP0000759_abnormal_skeletal_muscle1.15415346
36MP0003786_premature_aging1.10908600
37MP0008004_abnormal_stomach_pH1.10151821
38MP0003123_paternal_imprinting1.09228825
39MP0003122_maternal_imprinting1.09169829
40MP0005389_reproductive_system_phenotype1.05136229
41MP0004142_abnormal_muscle_tone1.04210167
42MP0000750_abnormal_muscle_regeneration0.98194257
43MP0000049_abnormal_middle_ear0.96520102
44MP0005508_abnormal_skeleton_morphology0.94008168
45MP0010030_abnormal_orbit_morphology0.93582716
46MP0002060_abnormal_skin_morphology0.91327563
47MP0003959_abnormal_lean_body0.91184839
48MP0005394_taste/olfaction_phenotype0.90489203
49MP0005499_abnormal_olfactory_system0.90489203
50MP0002249_abnormal_larynx_morphology0.88120325
51MP0000749_muscle_degeneration0.87521606
52MP0002109_abnormal_limb_morphology0.87013749
53MP0005423_abnormal_somatic_nervous0.85908561
54MP0005645_abnormal_hypothalamus_physiol0.81913840
55MP0000613_abnormal_salivary_gland0.77811104
56MP0002210_abnormal_sex_determination0.77493699
57MP0000163_abnormal_cartilage_morphology0.77050577
58MP0002638_abnormal_pupillary_reflex0.76479910
59MP0000685_abnormal_immune_system0.76469539
60MP0003121_genomic_imprinting0.75717511
61MP0005369_muscle_phenotype0.75349728
62MP0000003_abnormal_adipose_tissue0.74345038
63MP0002115_abnormal_skeleton_extremities0.73211117
64MP0009046_muscle_twitch0.73070242
65MP0001346_abnormal_lacrimal_gland0.72222337
66MP0005551_abnormal_eye_electrophysiolog0.71739261
67MP0003763_abnormal_thymus_physiology0.71280022
68MP0003806_abnormal_nucleotide_metabolis0.71150055
69MP0000372_irregular_coat_pigmentation0.70189715
70MP0004036_abnormal_muscle_relaxation0.69157145
71MP0006036_abnormal_mitochondrial_physio0.68899663
72MP0010386_abnormal_urinary_bladder0.65590712
73MP0004087_abnormal_muscle_fiber0.64294682
74MP0000733_abnormal_muscle_development0.63721663
75MP0002932_abnormal_joint_morphology0.63641637
76MP0001119_abnormal_female_reproductive0.62334008
77MP0003718_maternal_effect0.61954984
78MP0002106_abnormal_muscle_physiology0.61952982
79MP0001270_distended_abdomen0.61741039
80MP0006292_abnormal_olfactory_placode0.61529535
81MP0002970_abnormal_white_adipose0.61221173
82MP0002269_muscular_atrophy0.59869952
83MP0005452_abnormal_adipose_tissue0.59122266
84MP0002114_abnormal_axial_skeleton0.58590898
85MP0001986_abnormal_taste_sensitivity0.58587288
86MP0002938_white_spotting0.58005842
87MP0008877_abnormal_DNA_methylation0.57925878
88MP0005408_hypopigmentation0.57888825
89MP0003942_abnormal_urinary_system0.57675582
90MP0001664_abnormal_digestion0.57544064
91MP0005535_abnormal_body_temperature0.57395035
92MP0002233_abnormal_nose_morphology0.56546052
93MP0001919_abnormal_reproductive_system0.56192248
94MP0003937_abnormal_limbs/digits/tail_de0.55850662
95MP0002405_respiratory_system_inflammati0.54426190
96MP0004484_altered_response_of0.54351679
97MP0002736_abnormal_nociception_after0.52991519
98MP0002184_abnormal_innervation0.52430561
99MP0001502_abnormal_circadian_rhythm0.52213853
100MP0008872_abnormal_physiological_respon0.52160787

Predicted human phenotypes

RankGene SetZ-score
1Ulnar deviation of the wrist (HP:0003049)6.59246806
2Reticulocytopenia (HP:0001896)5.80940906
3Abnormality of cells of the erythroid lineage (HP:0012130)5.55365612
4Distal arthrogryposis (HP:0005684)4.18195962
5Abnormal number of erythroid precursors (HP:0012131)4.17709000
6Pulmonary artery stenosis (HP:0004415)3.78969873
7Renal Fanconi syndrome (HP:0001994)3.77607308
8Abnormality of midbrain morphology (HP:0002418)3.73475877
9Molar tooth sign on MRI (HP:0002419)3.73475877
10Small epiphyses (HP:0010585)3.52301502
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.49894701
12Macrocytic anemia (HP:0001972)3.47528979
13Bifid tongue (HP:0010297)3.44616817
14Increased hepatocellular lipid droplets (HP:0006565)3.33037570
15Calcaneovalgus deformity (HP:0001848)3.29250605
16Abnormality of the phalanges of the hallux (HP:0010057)3.18883865
17Irregular epiphyses (HP:0010582)3.14445131
18Round ear (HP:0100830)3.14127293
19Trismus (HP:0000211)3.12747254
20Lipid accumulation in hepatocytes (HP:0006561)3.12136569
21Spontaneous abortion (HP:0005268)3.11330254
22Delayed epiphyseal ossification (HP:0002663)3.00504929
23Short middle phalanx of the 5th finger (HP:0004220)2.96763197
24Bile duct proliferation (HP:0001408)2.95329977
25Abnormal biliary tract physiology (HP:0012439)2.95329977
26Absent thumb (HP:0009777)2.91854491
27Irregular vertebral endplates (HP:0003301)2.83180382
28Deformed tarsal bones (HP:0008119)2.81097605
29Mitochondrial inheritance (HP:0001427)2.79622485
30Partial duplication of the phalanx of hand (HP:0009999)2.78809487
31Absent phalangeal crease (HP:0006109)2.78466069
32Tracheal stenosis (HP:0002777)2.74611035
333-Methylglutaconic aciduria (HP:0003535)2.71551497
34Redundant skin (HP:0001582)2.68012937
35Nasal speech (HP:0001611)2.67519804
36Large eyes (HP:0001090)2.61250597
37Aplastic anemia (HP:0001915)2.59277462
38Rib fusion (HP:0000902)2.59262702
39Partial duplication of thumb phalanx (HP:0009944)2.52179102
40Increased intramyocellular lipid droplets (HP:0012240)2.52176319
41Respiratory difficulties (HP:0002880)2.48267842
42Abnormality of renal resorption (HP:0011038)2.47841065
43Myokymia (HP:0002411)2.47591889
44Recurrent bronchitis (HP:0002837)2.42657450
4511 pairs of ribs (HP:0000878)2.41603000
46Chronic sinusitis (HP:0011109)2.35967368
47Microretrognathia (HP:0000308)2.31293846
48Premature skin wrinkling (HP:0100678)2.30802146
49Hepatocellular necrosis (HP:0001404)2.30306299
50Symphalangism affecting the phalanges of the hand (HP:0009773)2.29872212
51Wide anterior fontanel (HP:0000260)2.27889914
52Pallor (HP:0000980)2.27606512
53Abnormal finger flexion creases (HP:0006143)2.23929375
54Reduced antithrombin III activity (HP:0001976)2.22070740
55Carpal bone hypoplasia (HP:0001498)2.22026590
56Exertional dyspnea (HP:0002875)2.21461724
57Long clavicles (HP:0000890)2.20709057
58Increased CSF lactate (HP:0002490)2.17665617
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17490192
60Abnormal cartilage morphology (HP:0002763)2.16540028
61Thrombocytosis (HP:0001894)2.12143514
62Abnormality of the vertebral endplates (HP:0005106)2.12060669
63Acute necrotizing encephalopathy (HP:0006965)2.12042470
64Nephronophthisis (HP:0000090)2.09807433
65Increased muscle lipid content (HP:0009058)2.04749351
66Hepatic necrosis (HP:0002605)2.02095031
67Type I transferrin isoform profile (HP:0003642)2.00486883
68Abnormality of the calcaneus (HP:0008364)1.98500648
69Acute encephalopathy (HP:0006846)1.97858224
70Abnormal protein glycosylation (HP:0012346)1.96165565
71Abnormal glycosylation (HP:0012345)1.96165565
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96165565
73Abnormal protein N-linked glycosylation (HP:0012347)1.96165565
74Asplenia (HP:0001746)1.95948742
75Deep philtrum (HP:0002002)1.92194660
76Stenosis of the external auditory canal (HP:0000402)1.92035122
77Abnormality of the renal medulla (HP:0100957)1.91502330
78Broad distal phalanx of finger (HP:0009836)1.90291309
79Abnormal mitochondria in muscle tissue (HP:0008316)1.90038675
80Pancreatic cysts (HP:0001737)1.89607387
81Missing ribs (HP:0000921)1.89228961
82Short femoral neck (HP:0100864)1.84138462
83Patent foramen ovale (HP:0001655)1.83023765
84Mild short stature (HP:0003502)1.82704046
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.81417685
86Facial cleft (HP:0002006)1.80869427
87Abnormal delivery (HP:0001787)1.79733895
88Malignant hyperthermia (HP:0002047)1.78428025
89Fetal akinesia sequence (HP:0001989)1.77321977
90Short hallux (HP:0010109)1.76775076
91Bronchitis (HP:0012387)1.76671829
92Optic nerve coloboma (HP:0000588)1.75882542
93Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75494982
94Abnormality of femoral epiphyses (HP:0006499)1.75494982
95Limited hip movement (HP:0008800)1.75023802
96Abnormality of placental membranes (HP:0011409)1.73048764
97Amniotic constriction ring (HP:0009775)1.73048764
98Abnormality of the epiphysis of the femoral head (HP:0010574)1.71597866
99Autoimmune hemolytic anemia (HP:0001890)1.71152967
100Osteoarthritis (HP:0002758)1.70843006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK8.71468647
2TLK18.34847827
3STK163.43512657
4VRK12.93671782
5TXK2.26949055
6WNK42.08170281
7RPS6KA52.07739372
8PTK61.97396355
9LRRK21.92573868
10CAMKK21.82745783
11NME21.78020841
12CDK191.59632230
13EPHB21.58266093
14PAK31.54488762
15MYLK1.36504711
16MAP2K71.26614657
17CDK81.26537516
18NLK1.24849281
19DAPK31.21326906
20PIM11.20386489
21PKN11.17753403
22DYRK21.17298817
23MARK21.15720902
24NUAK11.13929512
25BRSK21.13725945
26BCKDK1.11481989
27PIK3CG1.00396689
28CHEK20.99180289
29TYK20.95673807
30IRAK10.91701637
31ABL20.90663936
32BRSK10.90127436
33MAP3K60.88014004
34AURKA0.86305156
35PRKCQ0.78258600
36ILK0.76602334
37FRK0.70717993
38STK390.64238251
39TEC0.63814260
40MAP3K120.63468683
41TNIK0.62558595
42CAMK10.62385561
43PIK3CA0.61428011
44AKT30.60175813
45MAP2K60.59436385
46OBSCN0.59136065
47MAP2K40.59014397
48MARK30.56539388
49MUSK0.56361112
50DMPK0.55047493
51PRKCI0.52855662
52TIE10.51370625
53BMPR1B0.50973660
54MAP4K10.50881277
55PINK10.49989358
56CAMK1G0.48394281
57JAK30.48390753
58ERBB20.48054905
59SGK2230.47788642
60SGK4940.47788642
61MAP3K40.46885925
62AKT20.46725657
63CAMK1D0.46626292
64PNCK0.46614563
65SGK20.46573626
66ADRBK10.46504229
67PAK20.46180513
68CAMKK10.46025041
69STK40.44828637
70JAK20.44050507
71WNK10.41730454
72OXSR10.40896570
73BTK0.38854956
74CASK0.36660044
75PRKCD0.36517806
76NTRK20.35736794
77CSNK1E0.34310470
78MINK10.33920022
79PAK10.33322033
80ITK0.32415291
81MAPK120.30348051
82ROCK10.30179001
83GRK10.28176480
84GSK3A0.26289770
85SGK10.26149480
86TAOK30.24981254
87SGK30.24559493
88KIT0.23779217
89PDGFRB0.22934325
90PRKCG0.22886373
91LYN0.21728983
92CSF1R0.21537290
93PRKCH0.18994184
94CSNK1G10.18685323
95CSNK1A10.18679416
96IGF1R0.18337141
97CSNK2A20.17827201
98STK110.17625138
99EPHA30.17543224
100MAP3K110.16355774

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.14109385
2Oxidative phosphorylation_Homo sapiens_hsa001904.65622281
3Systemic lupus erythematosus_Homo sapiens_hsa053224.24944369
4Parkinsons disease_Homo sapiens_hsa050123.99029076
5RNA polymerase_Homo sapiens_hsa030203.33957484
6Alcoholism_Homo sapiens_hsa050343.11786477
7Huntingtons disease_Homo sapiens_hsa050163.01303361
8Alzheimers disease_Homo sapiens_hsa050102.98490363
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.97478654
10Cardiac muscle contraction_Homo sapiens_hsa042602.90937614
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.90543155
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48778120
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.30409757
14Mineral absorption_Homo sapiens_hsa049781.63568431
15Protein export_Homo sapiens_hsa030601.51235668
16Pyrimidine metabolism_Homo sapiens_hsa002401.39110174
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36781004
18Sulfur relay system_Homo sapiens_hsa041221.35520841
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29331737
20Nucleotide excision repair_Homo sapiens_hsa034201.16528705
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12293376
22Peroxisome_Homo sapiens_hsa041461.11584411
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04111889
24Purine metabolism_Homo sapiens_hsa002300.96194359
25Viral carcinogenesis_Homo sapiens_hsa052030.95811104
26Circadian rhythm_Homo sapiens_hsa047100.94917744
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93405239
28Regulation of autophagy_Homo sapiens_hsa041400.92038537
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91958849
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79554473
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75598248
32ECM-receptor interaction_Homo sapiens_hsa045120.74348606
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73324600
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72335485
35Melanoma_Homo sapiens_hsa052180.68140389
36Homologous recombination_Homo sapiens_hsa034400.67664337
37Fatty acid elongation_Homo sapiens_hsa000620.65911938
38Nitrogen metabolism_Homo sapiens_hsa009100.65006217
39Proteasome_Homo sapiens_hsa030500.64515083
40Dilated cardiomyopathy_Homo sapiens_hsa054140.63240355
41RNA degradation_Homo sapiens_hsa030180.60394038
42beta-Alanine metabolism_Homo sapiens_hsa004100.59026377
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.57235583
44Basal transcription factors_Homo sapiens_hsa030220.56635740
45Primary immunodeficiency_Homo sapiens_hsa053400.54158601
46Chemical carcinogenesis_Homo sapiens_hsa052040.53671242
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52588725
48Metabolic pathways_Homo sapiens_hsa011000.51985057
49Ovarian steroidogenesis_Homo sapiens_hsa049130.51369066
50Glycerolipid metabolism_Homo sapiens_hsa005610.50777525
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50488445
52PPAR signaling pathway_Homo sapiens_hsa033200.50183077
53Fatty acid biosynthesis_Homo sapiens_hsa000610.50099363
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49825890
55Base excision repair_Homo sapiens_hsa034100.48669456
56Glutathione metabolism_Homo sapiens_hsa004800.48487534
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47843707
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46762141
59Linoleic acid metabolism_Homo sapiens_hsa005910.45060391
60RNA transport_Homo sapiens_hsa030130.44707479
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44652666
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44491206
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42038177
64DNA replication_Homo sapiens_hsa030300.40002416
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36820372
66Thyroid hormone synthesis_Homo sapiens_hsa049180.35039495
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32777102
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.30267612
69Insulin secretion_Homo sapiens_hsa049110.29760472
70Phototransduction_Homo sapiens_hsa047440.29432201
71Oxytocin signaling pathway_Homo sapiens_hsa049210.29278491
72Caffeine metabolism_Homo sapiens_hsa002320.26072760
73Propanoate metabolism_Homo sapiens_hsa006400.25774932
74Arachidonic acid metabolism_Homo sapiens_hsa005900.23978812
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22127681
76Cocaine addiction_Homo sapiens_hsa050300.22073894
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21685175
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20897470
79Vitamin digestion and absorption_Homo sapiens_hsa049770.20713473
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20268380
81N-Glycan biosynthesis_Homo sapiens_hsa005100.19664476
82Steroid biosynthesis_Homo sapiens_hsa001000.17319640
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16884975
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15530844
85ABC transporters_Homo sapiens_hsa020100.14440347
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13591317
87MAPK signaling pathway_Homo sapiens_hsa040100.12694029
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12339209
89Glucagon signaling pathway_Homo sapiens_hsa049220.12059906
90Fanconi anemia pathway_Homo sapiens_hsa034600.11795782
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11582062
92Spliceosome_Homo sapiens_hsa030400.11318509
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.10473388
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09489180
95Malaria_Homo sapiens_hsa051440.09348708
96Hematopoietic cell lineage_Homo sapiens_hsa046400.09307868
97Focal adhesion_Homo sapiens_hsa045100.09023913
98Amphetamine addiction_Homo sapiens_hsa050310.08775225
99Protein digestion and absorption_Homo sapiens_hsa049740.08250383
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.08248514

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