RPL36A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)9.72466365
2ribosomal small subunit assembly (GO:0000028)9.39307494
3* translational termination (GO:0006415)9.36798994
4ribosomal small subunit biogenesis (GO:0042274)8.82080966
5* translational elongation (GO:0006414)8.00832976
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.89961388
7* cotranslational protein targeting to membrane (GO:0006613)7.74280020
8* protein targeting to ER (GO:0045047)7.73645271
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.39867436
10maturation of SSU-rRNA (GO:0030490)7.39360108
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.31711658
12* cellular protein complex disassembly (GO:0043624)7.25024122
13* protein localization to endoplasmic reticulum (GO:0070972)7.24793249
14* viral life cycle (GO:0019058)7.21540065
15* translational initiation (GO:0006413)6.93291733
16ribosomal large subunit biogenesis (GO:0042273)6.62419654
17* protein complex disassembly (GO:0043241)6.34054660
18* macromolecular complex disassembly (GO:0032984)5.92660394
19* nuclear-transcribed mRNA catabolic process (GO:0000956)5.26028327
20* protein targeting to membrane (GO:0006612)5.12831674
21ribonucleoprotein complex biogenesis (GO:0022613)5.08196287
22* translation (GO:0006412)5.00198575
23chaperone-mediated protein transport (GO:0072321)4.99771112
24* mRNA catabolic process (GO:0006402)4.98996649
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.73614714
26* RNA catabolic process (GO:0006401)4.67124003
27respiratory electron transport chain (GO:0022904)4.54515479
28electron transport chain (GO:0022900)4.43169578
29DNA deamination (GO:0045006)4.42815728
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.38751197
31formation of translation preinitiation complex (GO:0001731)4.37559132
32rRNA processing (GO:0006364)4.07371483
33rRNA metabolic process (GO:0016072)3.92495120
34DNA strand elongation involved in DNA replication (GO:0006271)3.83264518
35cellular component biogenesis (GO:0044085)3.81646520
36telomere maintenance via semi-conservative replication (GO:0032201)3.80240798
37DNA strand elongation (GO:0022616)3.64705646
38regulation of mitochondrial translation (GO:0070129)3.63676212
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54596263
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.54596263
41NADH dehydrogenase complex assembly (GO:0010257)3.54596263
42DNA unwinding involved in DNA replication (GO:0006268)3.48395939
43protein complex biogenesis (GO:0070271)3.48322217
44* establishment of protein localization to membrane (GO:0090150)3.45476583
45mitochondrial respiratory chain complex assembly (GO:0033108)3.42506350
46protein neddylation (GO:0045116)3.39792004
47DNA replication initiation (GO:0006270)3.38581617
48telomere maintenance via recombination (GO:0000722)3.32675876
49spliceosomal snRNP assembly (GO:0000387)3.25823829
50oxidative phosphorylation (GO:0006119)3.25746975
51ATP biosynthetic process (GO:0006754)3.24413327
52* establishment of protein localization to organelle (GO:0072594)3.24126544
53* protein targeting (GO:0006605)3.20636537
54inner mitochondrial membrane organization (GO:0007007)3.19180634
55protein targeting to mitochondrion (GO:0006626)3.15809259
56establishment of integrated proviral latency (GO:0075713)3.15150101
57ncRNA 3-end processing (GO:0043628)3.14237446
58mitotic recombination (GO:0006312)3.14178405
59purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13778123
60pseudouridine synthesis (GO:0001522)3.11466487
61ribosome biogenesis (GO:0042254)3.11359905
62spliceosomal complex assembly (GO:0000245)3.10558119
63purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10393836
64negative regulation of RNA splicing (GO:0033119)3.07823427
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06967906
66telomere maintenance via telomere lengthening (GO:0010833)3.02326243
67ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01276821
68establishment of protein localization to mitochondrion (GO:0072655)2.99604118
69CENP-A containing nucleosome assembly (GO:0034080)2.98557239
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96194925
71chromatin remodeling at centromere (GO:0031055)2.95989713
72* protein localization to organelle (GO:0033365)2.92965454
73protein localization to kinetochore (GO:0034501)2.91595142
74termination of RNA polymerase III transcription (GO:0006386)2.89167646
75transcription elongation from RNA polymerase III promoter (GO:0006385)2.89167646
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.88659300
77ribosome assembly (GO:0042255)2.88402690
78protein localization to mitochondrion (GO:0070585)2.86982188
79heterochromatin organization (GO:0070828)2.83543834
80kinetochore organization (GO:0051383)2.82654714
81DNA replication checkpoint (GO:0000076)2.82515023
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82296046
83ATP synthesis coupled proton transport (GO:0015986)2.82296046
84nucleobase biosynthetic process (GO:0046112)2.81534347
85proteasome assembly (GO:0043248)2.80623135
86ncRNA processing (GO:0034470)2.80109114
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79656788
88pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74701581
89DNA replication-dependent nucleosome organization (GO:0034723)2.73287636
90DNA replication-dependent nucleosome assembly (GO:0006335)2.73287636
91aerobic respiration (GO:0009060)2.73207647
92folic acid-containing compound biosynthetic process (GO:0009396)2.72470690
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70867066
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.70142985
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69911173
96DNA replication-independent nucleosome assembly (GO:0006336)2.69454068
97DNA replication-independent nucleosome organization (GO:0034724)2.69454068
98transcription-coupled nucleotide-excision repair (GO:0006283)2.69244203
99hydrogen ion transmembrane transport (GO:1902600)2.68202592
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66912191
101* gene expression (GO:0010467)2.66838700
102DNA damage response, detection of DNA damage (GO:0042769)2.65979380
103termination of RNA polymerase II transcription (GO:0006369)2.64969437
104histone exchange (GO:0043486)2.64798250
105purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.64163343
106purine nucleoside monophosphate biosynthetic process (GO:0009127)2.64163343
107nucleoside triphosphate biosynthetic process (GO:0009142)2.63537825
108histone mRNA metabolic process (GO:0008334)2.62394026
109* cellular component disassembly (GO:0022411)2.62140765
110ribonucleoprotein complex assembly (GO:0022618)2.61649602
111kinetochore assembly (GO:0051382)2.60414622
112UTP metabolic process (GO:0046051)2.59654180
113ncRNA metabolic process (GO:0034660)2.59601501
114UTP biosynthetic process (GO:0006228)2.59051828
115* protein localization to membrane (GO:0072657)2.58721722
116pyrimidine nucleotide catabolic process (GO:0006244)2.58213955
117mRNA splicing, via spliceosome (GO:0000398)2.57269064
118RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57269064
119RNA splicing, via transesterification reactions (GO:0000375)2.57208252
120IMP biosynthetic process (GO:0006188)2.56087080
121termination of RNA polymerase I transcription (GO:0006363)2.52760973
122purine nucleobase biosynthetic process (GO:0009113)2.52567071
123DNA-templated transcription, termination (GO:0006353)2.52293955
124protein localization to chromosome, centromeric region (GO:0071459)2.51319573
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50365309
126negative regulation of ligase activity (GO:0051352)2.50365309
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50163958
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50132955
129rRNA modification (GO:0000154)2.49799880
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49365217
131mitotic nuclear envelope disassembly (GO:0007077)2.48674279
132GTP biosynthetic process (GO:0006183)2.47843231
133ribonucleoprotein complex subunit organization (GO:0071826)2.46402534
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46268628
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46162428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.74778647
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.92676687
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07421013
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66347620
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.54566064
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.28706976
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.21280989
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14613947
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.02713918
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.98583069
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97629723
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96976672
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88318255
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77264822
15XRN2_22483619_ChIP-Seq_HELA_Human2.72558095
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71930706
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63757903
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62056967
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55454595
20VDR_23849224_ChIP-Seq_CD4+_Human2.35824637
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33337400
22TTF2_22483619_ChIP-Seq_HELA_Human2.23376800
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22789976
24DCP1A_22483619_ChIP-Seq_HELA_Human2.11577445
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06152769
26* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05539598
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05409824
28FOXP3_21729870_ChIP-Seq_TREG_Human2.02818946
29ELK1_19687146_ChIP-ChIP_HELA_Human2.01524946
30* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00602392
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95005038
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88371048
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83866845
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.73071618
35GABP_19822575_ChIP-Seq_HepG2_Human1.67838521
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59748565
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56971174
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56198147
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55547928
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.54955556
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54280431
42MYC_22102868_ChIP-Seq_BL_Human1.50884095
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50522539
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48538278
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47829573
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47503568
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47196274
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45006299
49AR_21909140_ChIP-Seq_LNCAP_Human1.43986604
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.43314755
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43039434
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.41193342
53CIITA_25753668_ChIP-Seq_RAJI_Human1.39263622
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34720215
55* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34415159
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.32498323
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32258287
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32232914
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.31428342
60* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31396630
61* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30321395
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.29862029
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29255871
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28856848
65VDR_21846776_ChIP-Seq_THP-1_Human1.26175690
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25290823
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23850790
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18244519
69MYC_18940864_ChIP-ChIP_HL60_Human1.18106229
70KDM5A_27292631_Chip-Seq_BREAST_Human1.17875739
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14691808
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13357669
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12920504
74* SPI1_23547873_ChIP-Seq_NB4_Human1.12422940
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11343109
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10560578
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.10285293
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10006950
79* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08528344
80* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05458803
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04987220
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03042030
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01702534
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00333604
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99365863
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99333815
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99079335
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96875168
89* SOX2_16153702_ChIP-ChIP_HESCs_Human0.96826132
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96685880
91TFEB_21752829_ChIP-Seq_HELA_Human0.95492662
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95436945
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94854238
94ZNF263_19887448_ChIP-Seq_K562_Human0.94692348
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93576802
96* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92979454
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92809600
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.92300253
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90201623
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89180500
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88971317
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87289900
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87094945
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87094945
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87094945
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87057484
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85638556
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85463623
109SCL_19346495_ChIP-Seq_HPC-7_Human0.84092309
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84032111
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82030500
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81663963
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80966724
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.78976414
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78102824
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75688116
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73333408
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.73117846
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72166340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.10156014
2MP0003693_abnormal_embryo_hatching4.62738283
3MP0004957_abnormal_blastocyst_morpholog3.82550044
4MP0010094_abnormal_chromosome_stability3.30284108
5MP0003077_abnormal_cell_cycle3.11594051
6MP0003111_abnormal_nucleus_morphology3.02858021
7MP0008057_abnormal_DNA_replication2.75666557
8MP0002396_abnormal_hematopoietic_system2.66939869
9MP0008058_abnormal_DNA_repair2.40855656
10MP0000566_synostosis2.33797861
11MP0008007_abnormal_cellular_replicative2.27375277
12MP0008932_abnormal_embryonic_tissue2.14719242
13MP0000490_abnormal_crypts_of2.04449750
14MP0003786_premature_aging1.83991756
15MP0010352_gastrointestinal_tract_polyps1.75425534
16MP0004808_abnormal_hematopoietic_stem1.70520018
17MP0008789_abnormal_olfactory_epithelium1.70397650
18MP0000350_abnormal_cell_proliferation1.67706169
19MP0003763_abnormal_thymus_physiology1.63037603
20MP0002653_abnormal_ependyma_morphology1.62176651
21MP0009333_abnormal_splenocyte_physiolog1.60125280
22MP0003123_paternal_imprinting1.58068640
23MP0001730_embryonic_growth_arrest1.56361647
24MP0002697_abnormal_eye_size1.48392777
25MP0001286_abnormal_eye_development1.48083019
26MP0003567_abnormal_fetal_cardiomyocyte1.47769623
27MP0006054_spinal_hemorrhage1.47140249
28MP0003941_abnormal_skin_development1.46123072
29MP0005174_abnormal_tail_pigmentation1.44070636
30MP0002132_abnormal_respiratory_system1.42982619
31MP0001545_abnormal_hematopoietic_system1.42674669
32MP0005397_hematopoietic_system_phenotyp1.42674669
33MP0003938_abnormal_ear_development1.41386755
34MP0001346_abnormal_lacrimal_gland1.38406545
35MP0005394_taste/olfaction_phenotype1.37114834
36MP0005499_abnormal_olfactory_system1.37114834
37MP0002019_abnormal_tumor_incidence1.34875951
38MP0002160_abnormal_reproductive_system1.34420335
39MP0002398_abnormal_bone_marrow1.30148722
40MP0002234_abnormal_pharynx_morphology1.29559009
41MP0002722_abnormal_immune_system1.27699592
42MP0000703_abnormal_thymus_morphology1.27149725
43MP0000313_abnormal_cell_death1.25835670
44MP0003937_abnormal_limbs/digits/tail_de1.25417001
45MP0001529_abnormal_vocalization1.24905640
46MP0000631_abnormal_neuroendocrine_gland1.24613830
47MP0001853_heart_inflammation1.22203429
48MP0010030_abnormal_orbit_morphology1.20797871
49MP0001697_abnormal_embryo_size1.20737104
50MP0002210_abnormal_sex_determination1.20172610
51MP0002095_abnormal_skin_pigmentation1.16522597
52MP0002080_prenatal_lethality1.16410515
53MP0000858_altered_metastatic_potential1.15712950
54MP0000689_abnormal_spleen_morphology1.15438218
55MP0001835_abnormal_antigen_presentation1.12955562
56MP0002938_white_spotting1.11157122
57MP0003315_abnormal_perineum_morphology1.11041738
58MP0003890_abnormal_embryonic-extraembry1.10834121
59MP0003186_abnormal_redox_activity1.10328119
60MP0001800_abnormal_humoral_immune1.10165527
61MP0010307_abnormal_tumor_latency1.09522365
62MP0002166_altered_tumor_susceptibility1.09384122
63MP0000685_abnormal_immune_system1.08308566
64MP0001672_abnormal_embryogenesis/_devel1.07793001
65MP0005380_embryogenesis_phenotype1.07793001
66MP0006072_abnormal_retinal_apoptosis1.07792042
67MP0000465_gastrointestinal_hemorrhage1.06163008
68MP0002429_abnormal_blood_cell1.06058465
69MP0002233_abnormal_nose_morphology1.05905896
70MP0003942_abnormal_urinary_system1.04345567
71MP0002085_abnormal_embryonic_tissue1.03283227
72MP0005075_abnormal_melanosome_morpholog1.02297821
73MP0002092_abnormal_eye_morphology1.00593215
74MP0003136_yellow_coat_color1.00427413
75MP0005501_abnormal_skin_physiology0.99922112
76MP0004142_abnormal_muscle_tone0.99220432
77MP0002086_abnormal_extraembryonic_tissu0.98470804
78MP0000372_irregular_coat_pigmentation0.98257866
79MP0000716_abnormal_immune_system0.97488811
80MP0005408_hypopigmentation0.97443370
81MP0003718_maternal_effect0.96322091
82MP0004197_abnormal_fetal_growth/weight/0.95693421
83MP0001873_stomach_inflammation0.95642790
84MP0003984_embryonic_growth_retardation0.94677306
85MP0002420_abnormal_adaptive_immunity0.94508242
86MP0002088_abnormal_embryonic_growth/wei0.94503320
87MP0002452_abnormal_antigen_presenting0.94322783
88MP0002084_abnormal_developmental_patter0.93802883
89MP0002006_tumorigenesis0.93412274
90MP0005023_abnormal_wound_healing0.92879720
91MP0001145_abnormal_male_reproductive0.92694722
92MP0002405_respiratory_system_inflammati0.92547908
93MP0001819_abnormal_immune_cell0.92281256
94MP0006035_abnormal_mitochondrial_morpho0.91428605
95MP0001188_hyperpigmentation0.90647054
96MP0010155_abnormal_intestine_physiology0.89836520
97MP0009250_abnormal_appendicular_skeleto0.89602875
98MP0004381_abnormal_hair_follicle0.89359606
99MP0003011_delayed_dark_adaptation0.88571780
100MP0005671_abnormal_response_to0.88351677
101MP0001293_anophthalmia0.87636034
102MP0003755_abnormal_palate_morphology0.86884458
103MP0005389_reproductive_system_phenotype0.86080197
104MP0000750_abnormal_muscle_regeneration0.83488458
105MP0003861_abnormal_nervous_system0.83431224
106MP0003806_abnormal_nucleotide_metabolis0.83368920
107MP0003121_genomic_imprinting0.82948128
108MP0009785_altered_susceptibility_to0.82560832
109MP0002723_abnormal_immune_serum0.82080091
110MP0001485_abnormal_pinna_reflex0.81711357
111MP0005025_abnormal_response_to0.80784647
112MP0000653_abnormal_sex_gland0.80376243
113MP0003436_decreased_susceptibility_to0.80238392
114MP0002277_abnormal_respiratory_mucosa0.79993994
115MP0000049_abnormal_middle_ear0.79404475
116MP0002148_abnormal_hypersensitivity_rea0.78809464
117MP0000678_abnormal_parathyroid_gland0.75666632
118MP0005391_vision/eye_phenotype0.75659350
119MP0000762_abnormal_tongue_morphology0.75584330
120MP0003119_abnormal_digestive_system0.74815479
121MP0005000_abnormal_immune_tolerance0.74759061
122MP0000358_abnormal_cell_content/0.74557188
123MP0008995_early_reproductive_senescence0.74411037
124MP0000537_abnormal_urethra_morphology0.74254887
125MP0002282_abnormal_trachea_morphology0.73960956
126MP0005076_abnormal_cell_differentiation0.73847208
127MP0002796_impaired_skin_barrier0.73646386
128MP0000477_abnormal_intestine_morphology0.73265772
129MP0009278_abnormal_bone_marrow0.72742756
130MP0001929_abnormal_gametogenesis0.72102133
131MP0002163_abnormal_gland_morphology0.71973009
132MP0001919_abnormal_reproductive_system0.71125429
133MP0002111_abnormal_tail_morphology0.70687068
134MP0002116_abnormal_craniofacial_bone0.68814103
135MP0000428_abnormal_craniofacial_morphol0.68216435
136MP0009053_abnormal_anal_canal0.67864764
137MP0001216_abnormal_epidermal_layer0.67712407
138MP0002638_abnormal_pupillary_reflex0.67531791
139MP0001881_abnormal_mammary_gland0.66564833
140MP0000026_abnormal_inner_ear0.66189474
141MP0003385_abnormal_body_wall0.65554472
142MP0002060_abnormal_skin_morphology0.65413769
143MP0009697_abnormal_copulation0.64077386
144MP0005377_hearing/vestibular/ear_phenot0.63894636
145MP0003878_abnormal_ear_physiology0.63894636
146MP0006292_abnormal_olfactory_placode0.63879668
147MP0002098_abnormal_vibrissa_morphology0.63875049
148MP0002249_abnormal_larynx_morphology0.63824026
149MP0005379_endocrine/exocrine_gland_phen0.63721935
150MP0006036_abnormal_mitochondrial_physio0.63312321
151MP0009672_abnormal_birth_weight0.62333224
152MP0000778_abnormal_nervous_system0.61268102
153MP0003283_abnormal_digestive_organ0.60295691
154MP0009931_abnormal_skin_appearance0.59806976
155MP0003936_abnormal_reproductive_system0.59423876
156MP0002932_abnormal_joint_morphology0.58649128

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.34724456
2Reticulocytopenia (HP:0001896)8.50561984
3Abnormal number of erythroid precursors (HP:0012131)8.34707548
4Macrocytic anemia (HP:0001972)6.31628711
5Pallor (HP:0000980)5.98965810
6Abnormal hemoglobin (HP:0011902)3.79691967
7Thrombocytosis (HP:0001894)3.71646724
8Colon cancer (HP:0003003)3.66331817
9Aplastic anemia (HP:0001915)3.50686755
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.29167154
11Cerebral edema (HP:0002181)3.23320557
12Oral leukoplakia (HP:0002745)3.15602082
1311 pairs of ribs (HP:0000878)3.12440538
14Absent thumb (HP:0009777)3.06567334
15Abnormality of reticulocytes (HP:0004312)3.02068000
16Septo-optic dysplasia (HP:0100842)2.88608035
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82648715
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82648715
19Trismus (HP:0000211)2.80905390
20Congenital, generalized hypertrichosis (HP:0004540)2.80237117
21Multiple enchondromatosis (HP:0005701)2.79104033
22Depressed nasal ridge (HP:0000457)2.72322959
23Increased hepatocellular lipid droplets (HP:0006565)2.70666770
24Increased muscle lipid content (HP:0009058)2.61152621
25Selective tooth agenesis (HP:0001592)2.60119732
26Birth length less than 3rd percentile (HP:0003561)2.56329859
27Stenosis of the external auditory canal (HP:0000402)2.52775378
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51549741
29Rough bone trabeculation (HP:0100670)2.46322216
30IgM deficiency (HP:0002850)2.46293882
31Mitochondrial inheritance (HP:0001427)2.42242436
32Leukodystrophy (HP:0002415)2.39040392
33Microretrognathia (HP:0000308)2.37443999
34Breast hypoplasia (HP:0003187)2.36530553
35Lactic acidosis (HP:0003128)2.35749374
36Exertional dyspnea (HP:0002875)2.35328465
37Duplication of thumb phalanx (HP:0009942)2.32439115
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32045915
39Acute necrotizing encephalopathy (HP:0006965)2.31287186
40Respiratory failure (HP:0002878)2.28225726
41Lipid accumulation in hepatocytes (HP:0006561)2.27873476
42Triphalangeal thumb (HP:0001199)2.26707493
43Myelodysplasia (HP:0002863)2.26608815
44Thick lower lip vermilion (HP:0000179)2.25793726
45Migraine (HP:0002076)2.24923930
46Asplenia (HP:0001746)2.24894568
47Hypoplasia of the radius (HP:0002984)2.24172379
48Carpal bone hypoplasia (HP:0001498)2.23009237
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22671131
50Hepatocellular necrosis (HP:0001404)2.18333892
51Increased CSF lactate (HP:0002490)2.16710551
52Glossoptosis (HP:0000162)2.16599069
53Optic disc pallor (HP:0000543)2.14644502
54Abnormality of the preputium (HP:0100587)2.14047914
55Abnormality of the parietal bone (HP:0002696)2.08994021
56Abnormality of renal resorption (HP:0011038)2.08796176
57Maternal diabetes (HP:0009800)2.08610915
58Absent septum pellucidum (HP:0001331)2.08083371
59Neoplasm of the pancreas (HP:0002894)2.06132378
60Rib fusion (HP:0000902)2.05948040
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.04283218
62Abnormal mitochondria in muscle tissue (HP:0008316)2.03957680
63Poikiloderma (HP:0001029)2.01773444
64Respiratory difficulties (HP:0002880)2.01687440
65Woolly hair (HP:0002224)1.99775983
66Patellar aplasia (HP:0006443)1.97980064
67Atresia of the external auditory canal (HP:0000413)1.97809014
68Chromsome breakage (HP:0040012)1.97249066
69Sparse eyelashes (HP:0000653)1.96494468
70Missing ribs (HP:0000921)1.96311128
71Premature graying of hair (HP:0002216)1.95582807
72Basal cell carcinoma (HP:0002671)1.94916200
73Abnormality of the heme biosynthetic pathway (HP:0010472)1.92877430
74Cleft eyelid (HP:0000625)1.92745879
753-Methylglutaconic aciduria (HP:0003535)1.91274893
76Meckel diverticulum (HP:0002245)1.90640160
77Anophthalmia (HP:0000528)1.88138070
78Aplasia/Hypoplasia of the patella (HP:0006498)1.88059187
79Abnormal number of incisors (HP:0011064)1.87215891
80Type I transferrin isoform profile (HP:0003642)1.86999866
81Abnormality of the septum pellucidum (HP:0007375)1.86395562
82Increased serum lactate (HP:0002151)1.85854370
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.85706996
84Abnormality of cochlea (HP:0000375)1.84845991
85Progressive macrocephaly (HP:0004481)1.84504211
86Abnormality of chromosome stability (HP:0003220)1.84173347
87Abnormality of the ileum (HP:0001549)1.83646695
88Increased intramyocellular lipid droplets (HP:0012240)1.83144630
89Hepatic necrosis (HP:0002605)1.82783622
90Petechiae (HP:0000967)1.82224306
91Pancytopenia (HP:0001876)1.82009840
92Hyperphosphaturia (HP:0003109)1.81283792
93Bilateral microphthalmos (HP:0007633)1.80613048
94Squamous cell carcinoma (HP:0002860)1.80062191
95Agnosia (HP:0010524)1.77561327
96Renal Fanconi syndrome (HP:0001994)1.77067365
97Esophageal atresia (HP:0002032)1.76626664
98Medulloblastoma (HP:0002885)1.75511434
99Horseshoe kidney (HP:0000085)1.74311257
100Nasolacrimal duct obstruction (HP:0000579)1.74095539
101Lymphoma (HP:0002665)1.73220355
102Abnormal trabecular bone morphology (HP:0100671)1.73202736
103Partial duplication of the phalanx of hand (HP:0009999)1.73167094
104Broad distal phalanx of finger (HP:0009836)1.73062848
105Cellular immunodeficiency (HP:0005374)1.71423090
106Premature ovarian failure (HP:0008209)1.70333843
107Exercise intolerance (HP:0003546)1.69931185
108Short middle phalanx of the 5th finger (HP:0004220)1.68828784
109Abnormality of the axillary hair (HP:0100134)1.67829704
110Abnormality of secondary sexual hair (HP:0009888)1.67829704
111Sparse lateral eyebrow (HP:0005338)1.67381722
112Hyperglycinemia (HP:0002154)1.67224590
113Microvesicular hepatic steatosis (HP:0001414)1.66816909
114Tracheoesophageal fistula (HP:0002575)1.66761987
115Short thumb (HP:0009778)1.66170141
116Facial cleft (HP:0002006)1.65832666
117Acute encephalopathy (HP:0006846)1.65622108
118Partial duplication of thumb phalanx (HP:0009944)1.65027977
119Secondary amenorrhea (HP:0000869)1.64360851
120Lethargy (HP:0001254)1.63934457
121Ectopic kidney (HP:0000086)1.63886076
122Progressive muscle weakness (HP:0003323)1.62879971
123Muscle fiber atrophy (HP:0100295)1.62584511
124Glycosuria (HP:0003076)1.62469580
125Abnormality of urine glucose concentration (HP:0011016)1.62469580
126Ependymoma (HP:0002888)1.61909659
127Abnormality of the anterior horn cell (HP:0006802)1.60749917
128Degeneration of anterior horn cells (HP:0002398)1.60749917
129Absent radius (HP:0003974)1.60702257
130Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.60639080
131Neoplasm of the colon (HP:0100273)1.60005134
132Morphological abnormality of the inner ear (HP:0011390)1.59661756
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.59163717
134Abnormality of the lacrimal duct (HP:0011481)1.59069703
135Megaloblastic anemia (HP:0001889)1.58956847
136Amaurosis fugax (HP:0100576)1.58778944
137Rhabdomyosarcoma (HP:0002859)1.57063551
138Forearm undergrowth (HP:0009821)1.55105893
139Hypoplasia of the pons (HP:0012110)1.53350565
140Sclerocornea (HP:0000647)1.52702692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.39824448
2VRK24.85712848
3WEE13.46030791
4BUB13.20994259
5RPS6KB22.89891411
6TLK12.82983199
7CDC72.56310328
8EIF2AK12.55861507
9EEF2K2.47245029
10SRPK12.32310778
11STK162.29414865
12VRK12.21352398
13LRRK22.14582474
14TAF12.05601109
15PIM21.99436765
16TGFBR11.96058247
17NEK21.81884663
18DYRK31.81673719
19EIF2AK31.73841161
20DYRK21.59908490
21PASK1.59063760
22ACVR1B1.58541474
23AURKB1.58469992
24MST41.58058646
25RPS6KA41.57759811
26CDK71.55768900
27MKNK11.54079134
28MAPKAPK31.45486649
29MAP4K11.45042622
30BRSK21.37838608
31TSSK61.33318577
32PLK11.31725906
33FLT31.30418828
34EPHB21.27779511
35TESK21.27447925
36TTK1.23459356
37STK101.21253516
38ILK1.12596991
39ATR1.12577450
40PNCK1.11204836
41MAP3K81.06804716
42PIM11.06660257
43TEC1.06386044
44KDR1.06110378
45MAP3K101.05529639
46PAK41.05259787
47SCYL21.05181517
48PLK41.00339455
49BTK0.99820007
50AURKA0.99220897
51PDK20.98943097
52NME10.98852372
53SMG10.98723131
54NUAK10.97173559
55CDK40.96738057
56PKN20.95743004
57CDK80.90486773
58EPHA20.89426288
59CDK190.89124252
60MKNK20.88387948
61STK240.85281425
62CSNK2A20.83950767
63RPS6KA50.83191053
64STK40.83183192
65EIF2AK20.81254304
66PBK0.80931926
67CHEK20.77940488
68KIT0.77246313
69BRAF0.73518632
70NEK10.72881056
71CSNK2A10.71561055
72WNK40.71362326
73ZAK0.71196637
74MAP2K30.70088323
75CHEK10.70062272
76CDK30.68167796
77CSNK1E0.68029981
78IKBKB0.67297933
79GRK60.67221730
80MAP3K110.66949215
81TYRO30.66584623
82BLK0.63879534
83PAK10.63417964
84CCNB10.60816849
85PAK20.60549997
86PLK30.58364036
87CSF1R0.58165475
88BRSK10.57756105
89CDK60.57391567
90MAP3K30.57163874
91CDK10.54376793
92TNIK0.53944872
93MAPK150.53810814
94ATM0.52857602
95ZAP700.51832755
96NLK0.51632161
97TYK20.50097228
98CDK20.46570312
99ARAF0.42469468
100LYN0.42386095
101MATK0.41854973
102MAP2K20.41731500
103IRAK30.40769784
104CDK11A0.40470859
105CDK120.40370571
106SYK0.40186684
107RPS6KC10.38983509
108RPS6KL10.38983509
109TGFBR20.38940094
110PRKCI0.38206285
111ABL20.38199801
112RPS6KA60.36007977
113IRAK40.35584273
114CLK10.35191656
115BCKDK0.35153690
116DAPK30.34870704
117PRKDC0.34444960
118ALK0.34291951
119STK30.34047408
120MAPKAPK20.33894951
121JAK30.33138815
122DMPK0.32762495
123LCK0.32359357
124MAPKAPK50.31623099
125AKT20.30065570
126TRIB30.27817375
127MAPK140.26999424
128DYRK1B0.26980111
129BMPR1B0.26613011
130RPS6KA10.26038035
131CDK150.26037708
132MUSK0.24947065
133AKT10.24671294
134PRKCG0.21724612
135CDK90.21555066
136FGFR10.18632156
137CDK140.18572486

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.66121326
2DNA replication_Homo sapiens_hsa030304.10636848
3Mismatch repair_Homo sapiens_hsa034303.49221341
4RNA polymerase_Homo sapiens_hsa030203.18236231
5Spliceosome_Homo sapiens_hsa030403.14891136
6Proteasome_Homo sapiens_hsa030503.12956405
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85202285
8Homologous recombination_Homo sapiens_hsa034402.58133979
9Nucleotide excision repair_Homo sapiens_hsa034202.48473007
10Base excision repair_Homo sapiens_hsa034102.39235720
11Pyrimidine metabolism_Homo sapiens_hsa002402.36849544
12RNA transport_Homo sapiens_hsa030132.33767603
13One carbon pool by folate_Homo sapiens_hsa006702.01283532
14Non-homologous end-joining_Homo sapiens_hsa034501.76002778
15Cell cycle_Homo sapiens_hsa041101.74215198
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73313879
17Fanconi anemia pathway_Homo sapiens_hsa034601.72076784
18Parkinsons disease_Homo sapiens_hsa050121.67529815
19Oxidative phosphorylation_Homo sapiens_hsa001901.63102614
20RNA degradation_Homo sapiens_hsa030181.58332609
21Protein export_Homo sapiens_hsa030601.51064106
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46045616
23Systemic lupus erythematosus_Homo sapiens_hsa053221.45574266
24Huntingtons disease_Homo sapiens_hsa050161.38595160
25p53 signaling pathway_Homo sapiens_hsa041151.38451971
26Basal transcription factors_Homo sapiens_hsa030221.37444432
27Purine metabolism_Homo sapiens_hsa002301.13138827
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08069072
29mRNA surveillance pathway_Homo sapiens_hsa030151.04888056
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00064643
31Epstein-Barr virus infection_Homo sapiens_hsa051690.99704934
32Primary immunodeficiency_Homo sapiens_hsa053400.97580295
33Alzheimers disease_Homo sapiens_hsa050100.97541871
34Sulfur relay system_Homo sapiens_hsa041220.94564484
35Antigen processing and presentation_Homo sapiens_hsa046120.93821886
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.92116051
37Herpes simplex infection_Homo sapiens_hsa051680.91233531
38Folate biosynthesis_Homo sapiens_hsa007900.89902333
39Pyruvate metabolism_Homo sapiens_hsa006200.75689188
40Viral carcinogenesis_Homo sapiens_hsa052030.74162275
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68518117
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65639006
43Hematopoietic cell lineage_Homo sapiens_hsa046400.62763325
44HTLV-I infection_Homo sapiens_hsa051660.61752380
45Pentose phosphate pathway_Homo sapiens_hsa000300.60674108
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60233695
47Thyroid cancer_Homo sapiens_hsa052160.59618208
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59616620
49Glutathione metabolism_Homo sapiens_hsa004800.59453490
50Small cell lung cancer_Homo sapiens_hsa052220.57475176
51Legionellosis_Homo sapiens_hsa051340.56178280
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54616640
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53037854
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52224680
55Hedgehog signaling pathway_Homo sapiens_hsa043400.49669776
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48800028
57Alcoholism_Homo sapiens_hsa050340.47759480
58Measles_Homo sapiens_hsa051620.47607067
59Apoptosis_Homo sapiens_hsa042100.46402073
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.45597205
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.45103164
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.44901380
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43146163
64N-Glycan biosynthesis_Homo sapiens_hsa005100.41309546
65Basal cell carcinoma_Homo sapiens_hsa052170.40554063
66Carbon metabolism_Homo sapiens_hsa012000.40372716
67Vitamin digestion and absorption_Homo sapiens_hsa049770.38207239
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36853811
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36431529
70MicroRNAs in cancer_Homo sapiens_hsa052060.34965008
71Arachidonic acid metabolism_Homo sapiens_hsa005900.34349415
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34074449
73Hepatitis B_Homo sapiens_hsa051610.33475426
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.33280254
75Bladder cancer_Homo sapiens_hsa052190.31933925
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31417412
77Acute myeloid leukemia_Homo sapiens_hsa052210.31130664
78Asthma_Homo sapiens_hsa053100.29686891
79Notch signaling pathway_Homo sapiens_hsa043300.29345493
80TGF-beta signaling pathway_Homo sapiens_hsa043500.29003895
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.28735477
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27803701
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.27316562
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27187535
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26885099
86Pathways in cancer_Homo sapiens_hsa052000.26709489
87Shigellosis_Homo sapiens_hsa051310.26300997
88Metabolic pathways_Homo sapiens_hsa011000.25962154
89Allograft rejection_Homo sapiens_hsa053300.25824359
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25792253
91Wnt signaling pathway_Homo sapiens_hsa043100.25775168
92Propanoate metabolism_Homo sapiens_hsa006400.25713316
93Cardiac muscle contraction_Homo sapiens_hsa042600.25621317
94HIF-1 signaling pathway_Homo sapiens_hsa040660.24944686
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24454709
96Leishmaniasis_Homo sapiens_hsa051400.24104371
97Biosynthesis of amino acids_Homo sapiens_hsa012300.23905109
98Selenocompound metabolism_Homo sapiens_hsa004500.23611027
99Colorectal cancer_Homo sapiens_hsa052100.22344706
100B cell receptor signaling pathway_Homo sapiens_hsa046620.21677723
101Oocyte meiosis_Homo sapiens_hsa041140.20792860
102Fatty acid elongation_Homo sapiens_hsa000620.20099510
103Influenza A_Homo sapiens_hsa051640.19893973
104Chronic myeloid leukemia_Homo sapiens_hsa052200.19698255
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19583831
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16665545
107Renin-angiotensin system_Homo sapiens_hsa046140.16024878
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15545773
109Viral myocarditis_Homo sapiens_hsa054160.15431356
110Fat digestion and absorption_Homo sapiens_hsa049750.14764687
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.14728120
112Tyrosine metabolism_Homo sapiens_hsa003500.14239721
113Arginine and proline metabolism_Homo sapiens_hsa003300.12984201
114Linoleic acid metabolism_Homo sapiens_hsa005910.12888852
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12518365
116Hippo signaling pathway_Homo sapiens_hsa043900.12457126
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12121519
118Malaria_Homo sapiens_hsa051440.11901698
119Toxoplasmosis_Homo sapiens_hsa051450.11409067
120Nitrogen metabolism_Homo sapiens_hsa009100.11205852
121Peroxisome_Homo sapiens_hsa041460.08895856
122Phototransduction_Homo sapiens_hsa047440.08814371
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.08787669
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08244874
125Steroid biosynthesis_Homo sapiens_hsa001000.07101750
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06335745
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03883080
128Galactose metabolism_Homo sapiens_hsa000520.01152243
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00792195
130Melanoma_Homo sapiens_hsa052180.00592031
131Chemical carcinogenesis_Homo sapiens_hsa05204-0.0337485
132Butanoate metabolism_Homo sapiens_hsa00650-0.0274362
133Olfactory transduction_Homo sapiens_hsa04740-0.0195323
134Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0122354
135Collecting duct acid secretion_Homo sapiens_hsa04966-0.0082942

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