RPL35A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.92151001
2* translational elongation (GO:0006414)8.88550720
3* cotranslational protein targeting to membrane (GO:0006613)8.77184847
4* protein targeting to ER (GO:0045047)8.75632021
5* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.37919392
6maturation of SSU-rRNA (GO:0030490)8.30381653
7* protein localization to endoplasmic reticulum (GO:0070972)8.17925241
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.14909043
9* viral life cycle (GO:0019058)8.13546847
10* cellular protein complex disassembly (GO:0043624)8.12598863
11* translational initiation (GO:0006413)7.59672415
12* protein complex disassembly (GO:0043241)7.06959709
13* macromolecular complex disassembly (GO:0032984)6.60288610
14* ribosomal large subunit biogenesis (GO:0042273)6.21929410
15* protein targeting to membrane (GO:0006612)5.84582302
16* nuclear-transcribed mRNA catabolic process (GO:0000956)5.75501204
17* mRNA catabolic process (GO:0006402)5.46156693
18* translation (GO:0006412)5.35973854
19chaperone-mediated protein transport (GO:0072321)5.10130690
20* RNA catabolic process (GO:0006401)5.06281618
21* ribonucleoprotein complex biogenesis (GO:0022613)5.01596910
22respiratory electron transport chain (GO:0022904)4.77331852
23electron transport chain (GO:0022900)4.66667978
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.58472578
25formation of translation preinitiation complex (GO:0001731)4.14130229
26DNA deamination (GO:0045006)4.03729661
27* rRNA processing (GO:0006364)3.98916217
28* establishment of protein localization to membrane (GO:0090150)3.94774098
29* rRNA metabolic process (GO:0016072)3.84465886
30* cellular component biogenesis (GO:0044085)3.72808582
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66934894
32protein complex biogenesis (GO:0070271)3.63396432
33mitochondrial respiratory chain complex assembly (GO:0033108)3.61719417
34regulation of mitochondrial translation (GO:0070129)3.61190996
35* protein targeting (GO:0006605)3.57039066
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.55996145
37NADH dehydrogenase complex assembly (GO:0010257)3.55996145
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55996145
39* establishment of protein localization to organelle (GO:0072594)3.54045522
40telomere maintenance via semi-conservative replication (GO:0032201)3.46922906
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45917130
42ATP synthesis coupled proton transport (GO:0015986)3.45917130
43DNA strand elongation involved in DNA replication (GO:0006271)3.44331245
44inner mitochondrial membrane organization (GO:0007007)3.38429931
45ATP biosynthetic process (GO:0006754)3.38094644
46protein neddylation (GO:0045116)3.30399771
47ncRNA 3-end processing (GO:0043628)3.25832432
48DNA strand elongation (GO:0022616)3.24502106
49establishment of integrated proviral latency (GO:0075713)3.23449893
50spliceosomal snRNP assembly (GO:0000387)3.21114705
51oxidative phosphorylation (GO:0006119)3.20380001
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20097787
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.19959565
54protein targeting to mitochondrion (GO:0006626)3.18818127
55spliceosomal complex assembly (GO:0000245)3.16561996
56rRNA modification (GO:0000154)3.15674147
57establishment of protein localization to mitochondrion (GO:0072655)3.06360018
58negative regulation of RNA splicing (GO:0033119)3.05386209
59DNA unwinding involved in DNA replication (GO:0006268)3.03901395
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02828604
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01480464
62telomere maintenance via recombination (GO:0000722)2.99794049
63* protein localization to membrane (GO:0072657)2.99285325
64protein localization to mitochondrion (GO:0070585)2.96248560
65termination of RNA polymerase III transcription (GO:0006386)2.94837176
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.94837176
67hydrogen ion transmembrane transport (GO:1902600)2.94811765
68DNA replication initiation (GO:0006270)2.93007411
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85707185
707-methylguanosine mRNA capping (GO:0006370)2.83415738
71* cellular component disassembly (GO:0022411)2.82564466
72mitotic recombination (GO:0006312)2.82193639
73proteasome assembly (GO:0043248)2.79634275
74DNA replication-independent nucleosome organization (GO:0034724)2.79172926
75DNA replication-independent nucleosome assembly (GO:0006336)2.79172926
76pseudouridine synthesis (GO:0001522)2.77927211
77aerobic respiration (GO:0009060)2.77854948
78intracellular protein transmembrane import (GO:0044743)2.76373645
797-methylguanosine RNA capping (GO:0009452)2.76124045
80RNA capping (GO:0036260)2.76124045
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75853095
82ribosome biogenesis (GO:0042254)2.72932967
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.72755924
84purine nucleoside monophosphate biosynthetic process (GO:0009127)2.72755924
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71593836
86* gene expression (GO:0010467)2.71049514
87mitochondrial transport (GO:0006839)2.69909788
88telomere maintenance via telomere lengthening (GO:0010833)2.68827112
89UTP biosynthetic process (GO:0006228)2.68640546
90histone exchange (GO:0043486)2.67965183
91kinetochore organization (GO:0051383)2.66420049
92nucleoside triphosphate biosynthetic process (GO:0009142)2.66019797
93* ncRNA processing (GO:0034470)2.64607541
94establishment of viral latency (GO:0019043)2.64407512
95chromatin remodeling at centromere (GO:0031055)2.63077085
96CENP-A containing nucleosome assembly (GO:0034080)2.62983093
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.62781628
98transcription-coupled nucleotide-excision repair (GO:0006283)2.61498468
99histone mRNA metabolic process (GO:0008334)2.61077428
100GTP biosynthetic process (GO:0006183)2.60903074
101* protein localization to organelle (GO:0033365)2.60594329
102deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59566048
103termination of RNA polymerase II transcription (GO:0006369)2.57574741
104ribonucleoprotein complex assembly (GO:0022618)2.56734297
105ribosome assembly (GO:0042255)2.56517325
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56038399
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52610268
108negative regulation of ligase activity (GO:0051352)2.52610268
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50235758
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.48156630
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.48031480
112folic acid-containing compound biosynthetic process (GO:0009396)2.47784220
113DNA replication checkpoint (GO:0000076)2.46683612
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46123313
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46123313
116RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46076765
117mRNA splicing, via spliceosome (GO:0000398)2.46076765
118RNA splicing, via transesterification reactions (GO:0000375)2.46056608
119* ncRNA metabolic process (GO:0034660)2.45692782
120termination of RNA polymerase I transcription (GO:0006363)2.45206383
121regulation of protein heterodimerization activity (GO:0043497)2.44645933
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.44427215
123DNA-templated transcription, termination (GO:0006353)2.44218059
124transcription elongation from RNA polymerase I promoter (GO:0006362)2.43602636
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.42888692
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.42888692
127antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42875063
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42000865
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41944862
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41944862
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41944862
132ribonucleoprotein complex subunit organization (GO:0071826)2.41790422
133* viral transcription (GO:0019083)10.9763408
134* translational termination (GO:0006415)10.5201548
135ribosomal small subunit assembly (GO:0000028)10.0199480
136ribosomal small subunit biogenesis (GO:0042274)10.0033368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.16493014
2MYC_18555785_ChIP-Seq_MESCs_Mouse5.01823715
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45616946
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04027071
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.74953461
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.32304454
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.29322521
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.09157652
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07847960
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91654200
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83057972
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82035994
13* XRN2_22483619_ChIP-Seq_HELA_Human2.81900745
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70200768
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.68622919
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66860394
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.64580883
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63927639
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59675484
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58552325
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52469850
22TTF2_22483619_ChIP-Seq_HELA_Human2.36365281
23* VDR_23849224_ChIP-Seq_CD4+_Human2.36118815
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32694970
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15808177
26* DCP1A_22483619_ChIP-Seq_HELA_Human2.07760117
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07621012
28FOXP3_21729870_ChIP-Seq_TREG_Human2.05087495
29* ELK1_19687146_ChIP-ChIP_HELA_Human2.04615468
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02661832
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02358555
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98995865
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93005940
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77190024
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68467734
36GABP_19822575_ChIP-Seq_HepG2_Human1.57544251
37* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53502942
38ELK1_22589737_ChIP-Seq_MCF10A_Human1.52653491
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51174529
40MYC_22102868_ChIP-Seq_BL_Human1.50664696
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50622521
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50321097
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46458144
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45616315
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43242671
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43052446
47VDR_21846776_ChIP-Seq_THP-1_Human1.41421672
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39695143
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39626302
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.37648809
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.37498863
52CIITA_25753668_ChIP-Seq_RAJI_Human1.37050956
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36068591
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35596695
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35499655
56AR_21909140_ChIP-Seq_LNCAP_Human1.30934724
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30535784
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29902144
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.29660112
60MYC_18940864_ChIP-ChIP_HL60_Human1.27350783
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.26824168
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23559533
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21814037
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19976699
65SPI1_23547873_ChIP-Seq_NB4_Human1.18214317
66KDM5A_27292631_Chip-Seq_BREAST_Human1.15602992
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15355572
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.14487509
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12215401
70* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11399563
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10982411
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.09154242
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08953216
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07948819
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06706816
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05500903
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05244706
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04196446
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.03111349
80* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02903782
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01569328
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01066628
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00552746
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00173872
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00105121
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99735426
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99568165
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98160332
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97918220
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97683482
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97039345
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96930754
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96196974
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95893729
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94375053
96TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93553516
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93352086
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93038874
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.92293428
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91277420
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90009998
102STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87309249
103MAF_26560356_Chip-Seq_TH2_Human0.87093090
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86421466
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85181741
106TFEB_21752829_ChIP-Seq_HELA_Human0.84649024
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.84229831
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.83938818
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83834816
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83510487
111* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83235133
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82626346
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82051723
114ELF5_23300383_ChIP-Seq_T47D_Human0.81809321
115ZNF263_19887448_ChIP-Seq_K562_Human0.81366842
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81177321
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81177321
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81177321
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81109464
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80118736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.91527917
2MP0003693_abnormal_embryo_hatching4.06614135
3MP0004957_abnormal_blastocyst_morpholog3.54011983
4MP0006292_abnormal_olfactory_placode3.48749307
5MP0010094_abnormal_chromosome_stability2.76833195
6MP0003077_abnormal_cell_cycle2.70872711
7MP0003111_abnormal_nucleus_morphology2.56672480
8MP0008057_abnormal_DNA_replication2.32818800
9MP0004381_abnormal_hair_follicle2.19201004
10MP0000566_synostosis2.12137291
11MP0001293_anophthalmia2.05499801
12MP0002396_abnormal_hematopoietic_system1.99932836
13MP0003763_abnormal_thymus_physiology1.93655976
14MP0008932_abnormal_embryonic_tissue1.89878066
15MP0008007_abnormal_cellular_replicative1.89430164
16MP0008058_abnormal_DNA_repair1.86497924
17MP0000490_abnormal_crypts_of1.86132197
18MP0003806_abnormal_nucleotide_metabolis1.85235921
19MP0003941_abnormal_skin_development1.84536817
20MP0003786_premature_aging1.79036447
21MP0002796_impaired_skin_barrier1.76328030
22MP0003136_yellow_coat_color1.73310230
23MP0010352_gastrointestinal_tract_polyps1.67714823
24MP0005174_abnormal_tail_pigmentation1.64634462
25MP0009333_abnormal_splenocyte_physiolog1.64583988
26MP0003890_abnormal_embryonic-extraembry1.51789813
27MP0005501_abnormal_skin_physiology1.51528474
28MP0008789_abnormal_olfactory_epithelium1.49818715
29MP0000350_abnormal_cell_proliferation1.43963733
30MP0001286_abnormal_eye_development1.43707119
31MP0001529_abnormal_vocalization1.42802663
32MP0006054_spinal_hemorrhage1.42446421
33MP0002160_abnormal_reproductive_system1.42380746
34MP0002132_abnormal_respiratory_system1.39403293
35MP0006036_abnormal_mitochondrial_physio1.38744355
36MP0001835_abnormal_antigen_presentation1.38032483
37MP0002166_altered_tumor_susceptibility1.37548313
38MP0000703_abnormal_thymus_morphology1.37304338
39MP0001853_heart_inflammation1.36588539
40MP0001346_abnormal_lacrimal_gland1.35778923
41MP0001800_abnormal_humoral_immune1.35070623
42MP0002398_abnormal_bone_marrow1.34348523
43MP0002697_abnormal_eye_size1.32188710
44MP0002722_abnormal_immune_system1.31514625
45MP0000685_abnormal_immune_system1.30716428
46MP0004808_abnormal_hematopoietic_stem1.30606241
47MP0001730_embryonic_growth_arrest1.29850225
48MP0003315_abnormal_perineum_morphology1.26596779
49MP0000049_abnormal_middle_ear1.26269778
50MP0006035_abnormal_mitochondrial_morpho1.25779517
51MP0003123_paternal_imprinting1.25520145
52MP0006072_abnormal_retinal_apoptosis1.24262749
53MP0003567_abnormal_fetal_cardiomyocyte1.23006284
54MP0003938_abnormal_ear_development1.22915455
55MP0002019_abnormal_tumor_incidence1.22510269
56MP0000465_gastrointestinal_hemorrhage1.22353271
57MP0000372_irregular_coat_pigmentation1.21303639
58MP0001216_abnormal_epidermal_layer1.17623351
59MP0002098_abnormal_vibrissa_morphology1.17114073
60MP0000631_abnormal_neuroendocrine_gland1.16989197
61MP0002420_abnormal_adaptive_immunity1.16662600
62MP0002095_abnormal_skin_pigmentation1.16539570
63MP0003937_abnormal_limbs/digits/tail_de1.15941064
64MP0002653_abnormal_ependyma_morphology1.15606019
65MP0002452_abnormal_antigen_presenting1.14341917
66MP0001819_abnormal_immune_cell1.14029100
67MP0000689_abnormal_spleen_morphology1.13729425
68MP0002006_tumorigenesis1.13242661
69MP0002148_abnormal_hypersensitivity_rea1.13069320
70MP0005394_taste/olfaction_phenotype1.12893946
71MP0005499_abnormal_olfactory_system1.12893946
72MP0002210_abnormal_sex_determination1.10955498
73MP0002405_respiratory_system_inflammati1.10658395
74MP0000858_altered_metastatic_potential1.09791741
75MP0002429_abnormal_blood_cell1.09390408
76MP0003436_decreased_susceptibility_to1.08996135
77MP0000716_abnormal_immune_system1.08556925
78MP0005671_abnormal_response_to1.07008371
79MP0002723_abnormal_immune_serum1.06811338
80MP0005025_abnormal_response_to1.06498581
81MP0005000_abnormal_immune_tolerance1.06310055
82MP0010234_abnormal_vibrissa_follicle1.05936278
83MP0002277_abnormal_respiratory_mucosa1.05361457
84MP0002060_abnormal_skin_morphology1.05206381
85MP0010030_abnormal_orbit_morphology1.04711267
86MP0009053_abnormal_anal_canal1.04678504
87MP0000383_abnormal_hair_follicle1.03953839
88MP0000313_abnormal_cell_death1.03823839
89MP0005389_reproductive_system_phenotype1.02478771
90MP0010155_abnormal_intestine_physiology1.02386599
91MP0000537_abnormal_urethra_morphology1.02363106
92MP0002938_white_spotting1.02107781
93MP0003011_delayed_dark_adaptation1.01498581
94MP0004142_abnormal_muscle_tone1.00829906
95MP0008995_early_reproductive_senescence0.99657902
96MP0001545_abnormal_hematopoietic_system0.99022393
97MP0005397_hematopoietic_system_phenotyp0.99022393
98MP0001873_stomach_inflammation0.98989545
99MP0001188_hyperpigmentation0.98439936
100MP0002638_abnormal_pupillary_reflex0.98226372
101MP0005075_abnormal_melanosome_morpholog0.97748968
102MP0009697_abnormal_copulation0.95929140
103MP0009785_altered_susceptibility_to0.94970186
104MP0002080_prenatal_lethality0.94624740
105MP0000377_abnormal_hair_follicle0.94012626
106MP0001697_abnormal_embryo_size0.93665046
107MP0001881_abnormal_mammary_gland0.92197866
108MP0002234_abnormal_pharynx_morphology0.92110828
109MP0002009_preneoplasia0.91945523
110MP0001919_abnormal_reproductive_system0.91307244
111MP0003942_abnormal_urinary_system0.91101311
112MP0002111_abnormal_tail_morphology0.90936199
113MP0002233_abnormal_nose_morphology0.90921982
114MP0003453_abnormal_keratinocyte_physiol0.90920334
115MP0001145_abnormal_male_reproductive0.89070738
116MP0003718_maternal_effect0.87990860
117MP0003186_abnormal_redox_activity0.86932165
118MP0002163_abnormal_gland_morphology0.85950458
119MP0009250_abnormal_appendicular_skeleto0.85082950
120MP0003866_abnormal_defecation0.84635144
121MP0001790_abnormal_immune_system0.82723940
122MP0005387_immune_system_phenotype0.82723940
123MP0003984_embryonic_growth_retardation0.82378319
124MP0002085_abnormal_embryonic_tissue0.82192420
125MP0002282_abnormal_trachea_morphology0.81566953
126MP0002092_abnormal_eye_morphology0.81087063
127MP0002088_abnormal_embryonic_growth/wei0.80696781
128MP0004133_heterotaxia0.80614055
129MP0010771_integument_phenotype0.79985722
130MP0009931_abnormal_skin_appearance0.79280320
131MP0001672_abnormal_embryogenesis/_devel0.78293478
132MP0005380_embryogenesis_phenotype0.78293478
133MP0001485_abnormal_pinna_reflex0.77488736
134MP0004947_skin_inflammation0.77073880
135MP0000653_abnormal_sex_gland0.76596249
136MP0001764_abnormal_homeostasis0.76376421
137MP0005023_abnormal_wound_healing0.76268338
138MP0000762_abnormal_tongue_morphology0.76244069
139MP0002084_abnormal_developmental_patter0.75585807
140MP0003755_abnormal_palate_morphology0.75542433
141MP0001727_abnormal_embryo_implantation0.73147139
142MP0002086_abnormal_extraembryonic_tissu0.72805796
143MP0004197_abnormal_fetal_growth/weight/0.72784692
144MP0002102_abnormal_ear_morphology0.72554777
145MP0000477_abnormal_intestine_morphology0.71852888
146MP0005408_hypopigmentation0.71438915
147MP0003861_abnormal_nervous_system0.71436733
148MP0003121_genomic_imprinting0.71392739
149MP0003119_abnormal_digestive_system0.71384638
150MP0008877_abnormal_DNA_methylation0.70832325
151MP0005379_endocrine/exocrine_gland_phen0.68837743
152MP0001929_abnormal_gametogenesis0.68393721
153MP0003283_abnormal_digestive_organ0.67485453
154MP0005391_vision/eye_phenotype0.65468799
155MP0005084_abnormal_gallbladder_morpholo0.65374111
156MP0000358_abnormal_cell_content/0.64204888
157MP0009672_abnormal_birth_weight0.62968642
158MP0001340_abnormal_eyelid_morphology0.61841796

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)9.42469521
2* Abnormality of cells of the erythroid lineage (HP:0012130)8.92775454
3* Abnormal number of erythroid precursors (HP:0012131)7.21121027
4* Macrocytic anemia (HP:0001972)6.65111598
5* Pallor (HP:0000980)6.05659599
6Abnormal hemoglobin (HP:0011902)3.97987521
7Colon cancer (HP:0003003)3.60186696
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.57812499
9Cerebral edema (HP:0002181)3.50088006
10Thrombocytosis (HP:0001894)3.32360110
1111 pairs of ribs (HP:0000878)3.23296133
12Congenital, generalized hypertrichosis (HP:0004540)3.20059582
13Stenosis of the external auditory canal (HP:0000402)3.17549143
14Abnormality of reticulocytes (HP:0004312)3.13430876
15Absent thumb (HP:0009777)3.12597002
16Septo-optic dysplasia (HP:0100842)3.02520280
17Increased muscle lipid content (HP:0009058)2.96239111
18Aplastic anemia (HP:0001915)2.93769937
19Increased hepatocellular lipid droplets (HP:0006565)2.90893693
20Oral leukoplakia (HP:0002745)2.82585779
21Trismus (HP:0000211)2.78717614
22Abnormality of renal resorption (HP:0011038)2.75434837
23Acute necrotizing encephalopathy (HP:0006965)2.74345902
24* Depressed nasal ridge (HP:0000457)2.69338214
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67780370
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67780370
27Multiple enchondromatosis (HP:0005701)2.65983579
28Woolly hair (HP:0002224)2.64268461
29Mitochondrial inheritance (HP:0001427)2.64067721
30Leukodystrophy (HP:0002415)2.62230207
31IgM deficiency (HP:0002850)2.59631946
32Lactic acidosis (HP:0003128)2.58089612
33Microvesicular hepatic steatosis (HP:0001414)2.57103232
34Exertional dyspnea (HP:0002875)2.48629297
35Asplenia (HP:0001746)2.46299822
36Respiratory failure (HP:0002878)2.45372928
37Lipid accumulation in hepatocytes (HP:0006561)2.44235756
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43884938
39Abnormal mitochondria in muscle tissue (HP:0008316)2.39528173
40Abnormality of secondary sexual hair (HP:0009888)2.36334382
41Abnormality of the axillary hair (HP:0100134)2.36334382
42Respiratory difficulties (HP:0002880)2.30101105
43Breast hypoplasia (HP:0003187)2.30008798
44Optic disc pallor (HP:0000543)2.25356485
45* Migraine (HP:0002076)2.25218794
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.23733711
47Triphalangeal thumb (HP:0001199)2.23625792
48Rough bone trabeculation (HP:0100670)2.22980059
49Hepatocellular necrosis (HP:0001404)2.21808275
50Abnormality of the parietal bone (HP:0002696)2.21587142
51Hypoplasia of the radius (HP:0002984)2.21569826
52* Thick lower lip vermilion (HP:0000179)2.21474750
53Absent septum pellucidum (HP:0001331)2.19875109
54Progressive macrocephaly (HP:0004481)2.19176824
55Selective tooth agenesis (HP:0001592)2.18394841
56Increased CSF lactate (HP:0002490)2.18118944
57Fragile nails (HP:0001808)2.17652885
58Glossoptosis (HP:0000162)2.13145693
59Rib fusion (HP:0000902)2.12586491
60Chronic otitis media (HP:0000389)2.12567921
61Hyperphosphaturia (HP:0003109)2.10936263
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10479604
63Microretrognathia (HP:0000308)2.06555762
64Birth length less than 3rd percentile (HP:0003561)2.06120327
65Concave nail (HP:0001598)2.04380768
66Carpal bone hypoplasia (HP:0001498)2.04224714
67Abnormality of methionine metabolism (HP:0010901)2.03014658
68Maternal diabetes (HP:0009800)2.02853680
69Abnormality of the septum pellucidum (HP:0007375)2.02353985
70Renal Fanconi syndrome (HP:0001994)2.02190865
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00452764
72Cleft eyelid (HP:0000625)1.99710183
73Missing ribs (HP:0000921)1.98442701
74Sparse eyelashes (HP:0000653)1.97953899
75Acute encephalopathy (HP:0006846)1.97319346
76Partial duplication of thumb phalanx (HP:0009944)1.95185480
77Increased intramyocellular lipid droplets (HP:0012240)1.93654807
78Parakeratosis (HP:0001036)1.93171949
79Elevated erythrocyte sedimentation rate (HP:0003565)1.91765993
80Abnormal urine phosphate concentration (HP:0012599)1.89595841
81Lethargy (HP:0001254)1.89559109
82Bilateral microphthalmos (HP:0007633)1.87827356
83Atresia of the external auditory canal (HP:0000413)1.86225801
84Horseshoe kidney (HP:0000085)1.85136402
85Basal cell carcinoma (HP:0002671)1.84751789
86Homocystinuria (HP:0002156)1.84720420
87Abnormality of homocysteine metabolism (HP:0010919)1.84720420
88Nasolacrimal duct obstruction (HP:0000579)1.84521169
89Partial duplication of the phalanx of hand (HP:0009999)1.84057450
90Abnormal number of incisors (HP:0011064)1.82901533
91Chromsome breakage (HP:0040012)1.82789632
92Megaloblastic anemia (HP:0001889)1.82758691
93Premature graying of hair (HP:0002216)1.82733601
94Myelodysplasia (HP:0002863)1.82456436
95Neoplasm of the pancreas (HP:0002894)1.82439220
96Glycosuria (HP:0003076)1.82028865
97Abnormality of urine glucose concentration (HP:0011016)1.82028865
98Abnormality of the preputium (HP:0100587)1.81997738
99Hepatic necrosis (HP:0002605)1.77754068
1003-Methylglutaconic aciduria (HP:0003535)1.77598539
101Amniotic constriction ring (HP:0009775)1.75984132
102Abnormality of placental membranes (HP:0011409)1.75984132
103Agnosia (HP:0010524)1.74653807
104Cellular immunodeficiency (HP:0005374)1.74594326
105Meckel diverticulum (HP:0002245)1.73458870
106Recurrent bronchitis (HP:0002837)1.71802750
107Abnormality of the lacrimal duct (HP:0011481)1.69248676
108Esophageal atresia (HP:0002032)1.68855264
109Exercise intolerance (HP:0003546)1.67998708
110Lymphoma (HP:0002665)1.67922025
111Absent radius (HP:0003974)1.67877878
112Premature ovarian failure (HP:0008209)1.67685054
113Petechiae (HP:0000967)1.67579750
114Aplasia/Hypoplasia of the thymus (HP:0010515)1.66731947
115Pancytopenia (HP:0001876)1.66299280
116Congenital ichthyosiform erythroderma (HP:0007431)1.65743411
117Hypoplasia of the pons (HP:0012110)1.64888236
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.64554837
119Patellar aplasia (HP:0006443)1.64274582
120Facial cleft (HP:0002006)1.63396619
121Anophthalmia (HP:0000528)1.63021867
122Increased serum lactate (HP:0002151)1.62778979
123Aplasia cutis congenita (HP:0001057)1.62353338
124Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61725367
125Abnormality of the ileum (HP:0001549)1.61565001
126Methylmalonic acidemia (HP:0002912)1.61071584
127Abnormality of the pons (HP:0007361)1.60663249
128Poikiloderma (HP:0001029)1.60068053
129Hypotrichosis (HP:0001006)1.59701103
130Abnormal trabecular bone morphology (HP:0100671)1.59565035
131Secondary amenorrhea (HP:0000869)1.59135123
132Aplasia/Hypoplasia of the patella (HP:0006498)1.58829948
133Abnormality of the anterior horn cell (HP:0006802)1.58615802
134Degeneration of anterior horn cells (HP:0002398)1.58615802
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57374618
136Renal tubular dysfunction (HP:0000124)1.56132557
137Type I transferrin isoform profile (HP:0003642)1.54947164
138Abnormality of T cells (HP:0002843)1.54669776
139Duplication of thumb phalanx (HP:0009942)1.54427004
140Squamous cell carcinoma (HP:0002860)1.53703554
141Aplasia involving forearm bones (HP:0009822)1.53210251
142Absent forearm bone (HP:0003953)1.53210251
143Ridged nail (HP:0001807)1.52542374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.57351720
2NME25.27152975
3WEE13.32409905
4BUB13.28188071
5TLK13.15427539
6RPS6KB22.88121596
7LRRK22.65781591
8TAF12.61743837
9MST42.46746062
10SRPK12.36344501
11EEF2K2.33058451
12STK162.28190477
13VRK12.18439097
14TGFBR12.05673620
15ZAK2.03997871
16CDC71.95885032
17DYRK31.91757000
18PIM21.90538802
19MAP4K11.80173540
20PASK1.76818590
21EIF2AK11.76503678
22PNCK1.57494526
23MAPKAPK31.54962959
24MAP3K101.53708214
25EIF2AK31.50731598
26NEK11.48481475
27AURKB1.45141341
28NEK21.38954422
29RPS6KA41.38777789
30KDR1.37660096
31ACVR1B1.37656440
32BLK1.34389330
33CDK71.32185301
34STK101.29040382
35TESK21.25681422
36MKNK11.22193820
37NUAK11.20801082
38TSSK61.20391313
39NME11.19718260
40ILK1.19702420
41BRSK21.16840012
42TEC1.16389601
43BTK1.12263675
44GRK61.05976455
45PBK1.03141066
46MAP3K31.01104158
47PLK11.00438462
48PAK40.98767973
49PIM10.97462460
50FLT30.96940602
51MAPK150.95962753
52CDK40.95905737
53MAP3K80.95491573
54EPHA20.93475792
55CDK190.92760272
56NLK0.91058917
57TTK0.91040025
58RPS6KA50.90685673
59AURKA0.89125125
60TYK20.86797764
61CSNK2A20.86107119
62ATR0.85813139
63SCYL20.82705278
64SMG10.81257863
65IKBKB0.77235598
66ZAP700.77110460
67STK240.76287788
68MAP2K20.75660375
69BCKDK0.73687261
70MAP3K120.72771739
71PKN20.70910093
72BRSK10.69649140
73MAP3K110.68429419
74STK40.68167290
75CSNK2A10.67406519
76MAP2K30.66391472
77CSNK1E0.64662010
78BRAF0.64407546
79SYK0.62632568
80MST1R0.62350084
81MKNK20.60535210
82KIT0.58680404
83ITK0.57876783
84CDK80.57815088
85CHEK10.57606810
86EIF2AK20.57158111
87CDK60.56829573
88PLK40.56629051
89CDK30.55272640
90IRAK40.54912273
91PAK10.54857178
92ARAF0.54647693
93TESK10.53956172
94IRAK30.53714010
95PIK3CG0.53656996
96CLK10.53367594
97ABL20.53051487
98CHEK20.52838431
99LCK0.51503334
100TNIK0.50336935
101LYN0.49709804
102DAPK30.48808695
103BMPR1B0.48378841
104PAK20.45228050
105PDK20.44782216
106MAPKAPK50.43550837
107PRKCI0.43063791
108CDK10.40183365
109CSF1R0.40028428
110ATM0.40001825
111JAK30.38409519
112CDK20.36156584
113INSRR0.36005798
114PLK30.35656291
115CCNB10.34971196
116ALK0.34951629
117RPS6KA60.34638147
118MAPKAPK20.34500004
119TGFBR20.33707996
120DYRK1B0.33049725
121CDK11A0.31712358
122RPS6KC10.30968753
123RPS6KL10.30968753
124EPHB20.30224985
125MAPK40.30016896
126TBK10.28816939
127DYRK20.28362588
128WNK40.27869048
129STK30.27531019
130PRKDC0.26742988
131DMPK0.23634883
132MUSK0.22880226
133RPS6KA10.21095841
134CDK90.18033397
135AKT10.17858085
136TYRO30.17344302
137FGFR10.16940340

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.46962498
2DNA replication_Homo sapiens_hsa030303.71917851
3Proteasome_Homo sapiens_hsa030503.27968310
4RNA polymerase_Homo sapiens_hsa030203.19238907
5Mismatch repair_Homo sapiens_hsa034303.14139657
6Spliceosome_Homo sapiens_hsa030403.13895849
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58073589
8Homologous recombination_Homo sapiens_hsa034402.30221514
9Nucleotide excision repair_Homo sapiens_hsa034202.28830225
10Pyrimidine metabolism_Homo sapiens_hsa002402.23656108
11RNA transport_Homo sapiens_hsa030132.10469741
12Base excision repair_Homo sapiens_hsa034102.09387772
13Oxidative phosphorylation_Homo sapiens_hsa001902.08449855
14Parkinsons disease_Homo sapiens_hsa050121.98601506
15Protein export_Homo sapiens_hsa030601.78511092
16One carbon pool by folate_Homo sapiens_hsa006701.74611915
17Huntingtons disease_Homo sapiens_hsa050161.59532642
18Non-homologous end-joining_Homo sapiens_hsa034501.51486557
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50582976
20Fanconi anemia pathway_Homo sapiens_hsa034601.50168945
21RNA degradation_Homo sapiens_hsa030181.48691777
22Cell cycle_Homo sapiens_hsa041101.38731778
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38586645
24Systemic lupus erythematosus_Homo sapiens_hsa053221.34250851
25Primary immunodeficiency_Homo sapiens_hsa053401.31184481
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31107818
27Basal transcription factors_Homo sapiens_hsa030221.30145019
28Alzheimers disease_Homo sapiens_hsa050101.27998497
29p53 signaling pathway_Homo sapiens_hsa041151.19890661
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.12506746
31Antigen processing and presentation_Homo sapiens_hsa046121.05679533
32Epstein-Barr virus infection_Homo sapiens_hsa051691.01523180
33Purine metabolism_Homo sapiens_hsa002301.00781616
34mRNA surveillance pathway_Homo sapiens_hsa030150.93130943
35Herpes simplex infection_Homo sapiens_hsa051680.85198455
36Pyruvate metabolism_Homo sapiens_hsa006200.83110172
37Sulfur relay system_Homo sapiens_hsa041220.82639957
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80957317
39Hematopoietic cell lineage_Homo sapiens_hsa046400.77692320
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71060356
41Viral carcinogenesis_Homo sapiens_hsa052030.68219497
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.67570876
43Vitamin digestion and absorption_Homo sapiens_hsa049770.65003744
44Folate biosynthesis_Homo sapiens_hsa007900.63452487
45Glutathione metabolism_Homo sapiens_hsa004800.62425077
46HTLV-I infection_Homo sapiens_hsa051660.62375109
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62015902
48Selenocompound metabolism_Homo sapiens_hsa004500.60213531
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.57764342
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.56220173
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54824573
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54694124
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53745769
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53651894
55Thyroid cancer_Homo sapiens_hsa052160.51640720
56Small cell lung cancer_Homo sapiens_hsa052220.51059181
57Legionellosis_Homo sapiens_hsa051340.50369762
58Measles_Homo sapiens_hsa051620.49948232
59Biosynthesis of amino acids_Homo sapiens_hsa012300.48913555
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48248406
61Alcoholism_Homo sapiens_hsa050340.47231493
62Carbon metabolism_Homo sapiens_hsa012000.45875574
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45793565
64Basal cell carcinoma_Homo sapiens_hsa052170.45006984
65Pentose phosphate pathway_Homo sapiens_hsa000300.44066465
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43793947
67Apoptosis_Homo sapiens_hsa042100.42509468
68Graft-versus-host disease_Homo sapiens_hsa053320.41293235
69Propanoate metabolism_Homo sapiens_hsa006400.39172109
70Arachidonic acid metabolism_Homo sapiens_hsa005900.39135111
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39004418
72Fatty acid elongation_Homo sapiens_hsa000620.37930221
73Asthma_Homo sapiens_hsa053100.37653397
74Cardiac muscle contraction_Homo sapiens_hsa042600.37185178
75Allograft rejection_Homo sapiens_hsa053300.37111135
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36885178
77N-Glycan biosynthesis_Homo sapiens_hsa005100.33834566
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33336615
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32713191
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30987466
81T cell receptor signaling pathway_Homo sapiens_hsa046600.30911788
82B cell receptor signaling pathway_Homo sapiens_hsa046620.30811391
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.30570464
84Acute myeloid leukemia_Homo sapiens_hsa052210.30459300
85Notch signaling pathway_Homo sapiens_hsa043300.30067454
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.29996936
87Wnt signaling pathway_Homo sapiens_hsa043100.29103196
88MicroRNAs in cancer_Homo sapiens_hsa052060.28876249
89Leishmaniasis_Homo sapiens_hsa051400.28544102
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.28348003
91Hepatitis B_Homo sapiens_hsa051610.27997337
92Shigellosis_Homo sapiens_hsa051310.27897357
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27657434
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26400583
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26320582
96Pathways in cancer_Homo sapiens_hsa052000.26274309
97Tyrosine metabolism_Homo sapiens_hsa003500.26272328
98TGF-beta signaling pathway_Homo sapiens_hsa043500.26046928
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25960495
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25821979
101Bladder cancer_Homo sapiens_hsa052190.25497313
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.25060835
103Metabolic pathways_Homo sapiens_hsa011000.23880585
104Steroid biosynthesis_Homo sapiens_hsa001000.21073743
105Other glycan degradation_Homo sapiens_hsa005110.19621333
106Chemical carcinogenesis_Homo sapiens_hsa052040.19575112
107Peroxisome_Homo sapiens_hsa041460.19541908
108HIF-1 signaling pathway_Homo sapiens_hsa040660.18533654
109Toxoplasmosis_Homo sapiens_hsa051450.18153165
110Collecting duct acid secretion_Homo sapiens_hsa049660.17351245
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16942217
112Renin-angiotensin system_Homo sapiens_hsa046140.16675494
113Pertussis_Homo sapiens_hsa051330.16672879
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15907631
115Viral myocarditis_Homo sapiens_hsa054160.15872350
116Autoimmune thyroid disease_Homo sapiens_hsa053200.15704411
117Influenza A_Homo sapiens_hsa051640.15133412
118Hedgehog signaling pathway_Homo sapiens_hsa043400.15021224
119Linoleic acid metabolism_Homo sapiens_hsa005910.14529807
120Colorectal cancer_Homo sapiens_hsa052100.13628100
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13234313
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12821475
123Chronic myeloid leukemia_Homo sapiens_hsa052200.12377302
124Oocyte meiosis_Homo sapiens_hsa041140.11403843
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11376517
126Hippo signaling pathway_Homo sapiens_hsa043900.09522012
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09339500
128Nitrogen metabolism_Homo sapiens_hsa009100.06955842
129Sulfur metabolism_Homo sapiens_hsa009200.06803607
130Fat digestion and absorption_Homo sapiens_hsa049750.06770263
131Galactose metabolism_Homo sapiens_hsa000520.05392820
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.04989609
133Phototransduction_Homo sapiens_hsa047440.04947397
134Regulation of autophagy_Homo sapiens_hsa041400.03017634
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02006047
136Arginine and proline metabolism_Homo sapiens_hsa003300.01998024
137Retinol metabolism_Homo sapiens_hsa008300.01902673
138Melanoma_Homo sapiens_hsa052180.01661617
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.00831820
140Tryptophan metabolism_Homo sapiens_hsa003800.00346415
141Caffeine metabolism_Homo sapiens_hsa00232-0.0098522

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