RPL31P61

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.92806117
2viral transcription (GO:0019083)5.24831941
3translational termination (GO:0006415)5.00864814
4ribosomal small subunit assembly (GO:0000028)4.80838467
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41561139
6ATP synthesis coupled proton transport (GO:0015986)4.41561139
7protein neddylation (GO:0045116)4.25296141
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.09112904
9translational elongation (GO:0006414)4.07385123
10cotranslational protein targeting to membrane (GO:0006613)4.06508711
11protein targeting to ER (GO:0045047)4.02179771
12somite development (GO:0061053)3.98241129
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95238676
14ribosomal small subunit biogenesis (GO:0042274)3.95000430
15chaperone-mediated protein transport (GO:0072321)3.90199737
16establishment of protein localization to endoplasmic reticulum (GO:0072599)3.86784403
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82633263
18negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76523083
19cellular protein complex disassembly (GO:0043624)3.73797093
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72291033
21protein localization to endoplasmic reticulum (GO:0070972)3.72184953
22maturation of SSU-rRNA (GO:0030490)3.63685154
23cell proliferation in forebrain (GO:0021846)3.62229952
24viral life cycle (GO:0019058)3.57755914
25pyrimidine nucleobase catabolic process (GO:0006208)3.57699252
26male meiosis I (GO:0007141)3.44162139
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.42007067
28valine metabolic process (GO:0006573)3.37600547
29regulation of feeding behavior (GO:0060259)3.28120200
30GTP biosynthetic process (GO:0006183)3.28025239
31behavioral response to ethanol (GO:0048149)3.24787120
32membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.24518582
33protein complex disassembly (GO:0043241)3.19642739
34regulation of cilium movement (GO:0003352)3.16695312
35forebrain neuron differentiation (GO:0021879)3.11918727
36translational initiation (GO:0006413)3.10574432
37regulation of isotype switching to IgG isotypes (GO:0048302)3.05128516
38phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.04206394
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03950256
40short-term memory (GO:0007614)3.03006691
41synapsis (GO:0007129)3.02769755
42nucleotide transmembrane transport (GO:1901679)3.01258316
43water-soluble vitamin biosynthetic process (GO:0042364)3.00971622
44macromolecular complex disassembly (GO:0032984)3.00682484
45parturition (GO:0007567)3.00379665
46olfactory bulb development (GO:0021772)3.00199080
47nonmotile primary cilium assembly (GO:0035058)2.97201965
48establishment of mitochondrion localization (GO:0051654)2.95039606
49membrane repolarization during action potential (GO:0086011)2.93017381
50regulation of penile erection (GO:0060405)2.90572572
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89461991
52mitochondrion transport along microtubule (GO:0047497)2.89461991
53epithelial cilium movement (GO:0003351)2.88908305
54negative regulation of DNA-templated transcription, elongation (GO:0032785)2.88372873
55dendritic spine morphogenesis (GO:0060997)2.87523342
56cerebral cortex radially oriented cell migration (GO:0021799)2.83775959
57substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.83053765
58substrate-independent telencephalic tangential migration (GO:0021826)2.83053765
59nucleobase catabolic process (GO:0046113)2.82515171
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.81197372
61positive regulation of potassium ion transmembrane transport (GO:1901381)2.80526279
62membrane repolarization (GO:0086009)2.79112680
63negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77991739
64protein polyglutamylation (GO:0018095)2.76478460
65cellular anion homeostasis (GO:0030002)2.72291142
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72110631
67indolalkylamine metabolic process (GO:0006586)2.71402403
68regulation of microtubule-based movement (GO:0060632)2.71341375
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70844770
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.70844770
71NADH dehydrogenase complex assembly (GO:0010257)2.70844770
72negative regulation of multicellular organism growth (GO:0040015)2.70209488
73kynurenine metabolic process (GO:0070189)2.67345800
74UTP biosynthetic process (GO:0006228)2.66699778
75ATP biosynthetic process (GO:0006754)2.66409625
76protein complex biogenesis (GO:0070271)2.66203294
77negative regulation of mast cell activation (GO:0033004)2.64101367
78phosphatidylcholine acyl-chain remodeling (GO:0036151)2.60712713
79protein K6-linked ubiquitination (GO:0085020)2.57101420
80cell migration in hindbrain (GO:0021535)2.56715433
81protein targeting to membrane (GO:0006612)2.56601400
82negative regulation of appetite (GO:0032099)2.55975378
83negative regulation of response to food (GO:0032096)2.55975378
84spinal cord development (GO:0021510)2.55143508
85synaptic transmission, cholinergic (GO:0007271)2.54838235
86endoderm formation (GO:0001706)2.54247683
87transmission of nerve impulse (GO:0019226)2.53677999
88detection of light stimulus involved in visual perception (GO:0050908)2.52214166
89detection of light stimulus involved in sensory perception (GO:0050962)2.52214166
90regulation of membrane repolarization (GO:0060306)2.51462849
91nuclear-transcribed mRNA catabolic process (GO:0000956)2.51040034
92neuronal action potential (GO:0019228)2.49931696
93UTP metabolic process (GO:0046051)2.49842995
94establishment of nucleus localization (GO:0040023)2.49550072
95positive regulation of sodium ion transmembrane transport (GO:1902307)2.49373280
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48963657
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48963657
98indole-containing compound catabolic process (GO:0042436)2.48796825
99indolalkylamine catabolic process (GO:0046218)2.48796825
100tryptophan catabolic process (GO:0006569)2.48796825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.07684972
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.49979281
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94306854
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75003281
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72852675
6VDR_22108803_ChIP-Seq_LS180_Human2.63179347
7ZNF274_21170338_ChIP-Seq_K562_Hela2.58343984
8IRF1_19129219_ChIP-ChIP_H3396_Human2.53182850
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39976028
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.29802453
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14302006
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05936989
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.04833387
14SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98834631
15REST_21632747_ChIP-Seq_MESCs_Mouse1.95191170
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94581917
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.92933900
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.92794447
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90820283
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.87563728
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81031022
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79134794
23RNF2_27304074_Chip-Seq_NSC_Mouse1.77628368
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77071364
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76794072
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73306751
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66939053
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59569098
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58764525
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58119103
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.54494073
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54348720
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51742491
34EWS_26573619_Chip-Seq_HEK293_Human1.49684421
35MYC_18940864_ChIP-ChIP_HL60_Human1.48474422
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47502081
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44286883
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44286883
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43173099
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40794369
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38656239
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.36501934
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.34796471
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32698679
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32256187
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30338869
47P300_19829295_ChIP-Seq_ESCs_Human1.29006786
48GBX2_23144817_ChIP-Seq_PC3_Human1.29000446
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28900286
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28482213
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.25567015
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.25089612
53CBP_20019798_ChIP-Seq_JUKART_Human1.24467987
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24467987
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23822515
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.23310914
57FUS_26573619_Chip-Seq_HEK293_Human1.22782442
58TAF15_26573619_Chip-Seq_HEK293_Human1.22758486
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.22619995
60ERA_21632823_ChIP-Seq_H3396_Human1.21011520
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17379617
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15806238
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14225494
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14029053
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12017354
66ER_23166858_ChIP-Seq_MCF-7_Human1.10835872
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10579485
68AR_21572438_ChIP-Seq_LNCaP_Human1.08578328
69TAF2_19829295_ChIP-Seq_ESCs_Human1.07609342
70IGF1R_20145208_ChIP-Seq_DFB_Human1.07379683
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07285284
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06942878
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06141793
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03071631
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02037851
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01739895
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01604723
78NCOR_22424771_ChIP-Seq_293T_Human1.00859250
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00066731
80TP53_22573176_ChIP-Seq_HFKS_Human0.99547687
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.98347126
82NANOG_20526341_ChIP-Seq_ESCs_Human0.98292650
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97478495
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97245777
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96857632
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94450136
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.93433770
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.93293113
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91392699
90RUNX2_22187159_ChIP-Seq_PCA_Human0.91277066
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90613509
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90040383
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90040383
94TCF4_22108803_ChIP-Seq_LS180_Human0.89449406
95TCF4_23295773_ChIP-Seq_U87_Human0.89152905
96SMAD4_21799915_ChIP-Seq_A2780_Human0.88310989
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88011552
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.87854881
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87794880
100AR_25329375_ChIP-Seq_VCAP_Human0.87588405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.55081002
2MP0006292_abnormal_olfactory_placode4.24063574
3MP0002653_abnormal_ependyma_morphology3.34557663
4MP0003787_abnormal_imprinting2.57014276
5MP0006276_abnormal_autonomic_nervous2.48731061
6MP0003122_maternal_imprinting2.42764851
7MP0008877_abnormal_DNA_methylation2.33400893
8MP0003011_delayed_dark_adaptation2.27010903
9MP0001188_hyperpigmentation2.25409871
10MP0008789_abnormal_olfactory_epithelium2.22114989
11MP0003646_muscle_fatigue2.21932027
12MP0005394_taste/olfaction_phenotype2.17925804
13MP0005499_abnormal_olfactory_system2.17925804
14MP0004885_abnormal_endolymph2.10596135
15MP0003121_genomic_imprinting2.07906200
16MP0003880_abnormal_central_pattern1.98824511
17MP0000778_abnormal_nervous_system1.90478814
18MP0005551_abnormal_eye_electrophysiolog1.85129858
19MP0001485_abnormal_pinna_reflex1.77630872
20MP0003878_abnormal_ear_physiology1.70885369
21MP0005377_hearing/vestibular/ear_phenot1.70885369
22MP0001984_abnormal_olfaction1.66882767
23MP0001968_abnormal_touch/_nociception1.65514346
24MP0003136_yellow_coat_color1.64080049
25MP0002102_abnormal_ear_morphology1.63361184
26MP0001293_anophthalmia1.63038506
27MP0004142_abnormal_muscle_tone1.62204264
28MP0002736_abnormal_nociception_after1.59928916
29MP0002938_white_spotting1.58422764
30MP0003123_paternal_imprinting1.58112869
31MP0002837_dystrophic_cardiac_calcinosis1.57143679
32MP0005423_abnormal_somatic_nervous1.51782067
33MP0002272_abnormal_nervous_system1.51320835
34MP0000631_abnormal_neuroendocrine_gland1.50454572
35MP0000566_synostosis1.50066817
36MP0002638_abnormal_pupillary_reflex1.49779388
37MP0008872_abnormal_physiological_respon1.49041461
38MP0008875_abnormal_xenobiotic_pharmacok1.46983471
39MP0002160_abnormal_reproductive_system1.45463075
40MP0002822_catalepsy1.39576863
41MP0009745_abnormal_behavioral_response1.39545412
42MP0000049_abnormal_middle_ear1.35808148
43MP0001440_abnormal_grooming_behavior1.35479187
44MP0004742_abnormal_vestibular_system1.34806492
45MP0001529_abnormal_vocalization1.27162828
46MP0002184_abnormal_innervation1.27082138
47MP0005389_reproductive_system_phenotype1.26637916
48MP0002557_abnormal_social/conspecific_i1.26456313
49MP0002234_abnormal_pharynx_morphology1.26251088
50MP0004145_abnormal_muscle_electrophysio1.24519947
51MP0005195_abnormal_posterior_eye1.22882837
52MP0002928_abnormal_bile_duct1.22428529
53MP0001905_abnormal_dopamine_level1.20565494
54MP0002063_abnormal_learning/memory/cond1.19755303
55MP0005084_abnormal_gallbladder_morpholo1.19661244
56MP0006072_abnormal_retinal_apoptosis1.19500170
57MP0002752_abnormal_somatic_nervous1.18176415
58MP0004133_heterotaxia1.17825590
59MP0009046_muscle_twitch1.17810618
60MP0002572_abnormal_emotion/affect_behav1.16315429
61MP0004782_abnormal_surfactant_physiolog1.14843021
62MP0002163_abnormal_gland_morphology1.14688062
63MP0003879_abnormal_hair_cell1.12853747
64MP0008058_abnormal_DNA_repair1.08836492
65MP0003890_abnormal_embryonic-extraembry1.08612967
66MP0003635_abnormal_synaptic_transmissio1.08485222
67MP0000955_abnormal_spinal_cord1.08009380
68MP0001986_abnormal_taste_sensitivity1.07789182
69MP0001486_abnormal_startle_reflex1.07683918
70MP0005645_abnormal_hypothalamus_physiol1.06789075
71MP0000026_abnormal_inner_ear1.05798213
72MP0005646_abnormal_pituitary_gland1.04358454
73MP0010030_abnormal_orbit_morphology1.03425653
74MP0001970_abnormal_pain_threshold1.02769554
75MP0001502_abnormal_circadian_rhythm1.01937510
76MP0002233_abnormal_nose_morphology0.98190879
77MP0005253_abnormal_eye_physiology0.97316845
78MP0002734_abnormal_mechanical_nocicepti0.97183627
79MP0003938_abnormal_ear_development0.95725756
80MP0002733_abnormal_thermal_nociception0.94033953
81MP0002735_abnormal_chemical_nociception0.93780677
82MP0002882_abnormal_neuron_morphology0.93184717
83MP0000534_abnormal_ureter_morphology0.92725434
84MP0001963_abnormal_hearing_physiology0.91825676
85MP0002876_abnormal_thyroid_physiology0.90318861
86MP0002064_seizures0.89950323
87MP0005410_abnormal_fertilization0.89085235
88MP0001919_abnormal_reproductive_system0.87537984
89MP0002210_abnormal_sex_determination0.87440380
90MP0003195_calcinosis0.85968460
91MP0004924_abnormal_behavior0.84457742
92MP0005386_behavior/neurological_phenoty0.84457742
93MP0004859_abnormal_synaptic_plasticity0.83984692
94MP0003942_abnormal_urinary_system0.83823332
95MP0001286_abnormal_eye_development0.81847777
96MP0002152_abnormal_brain_morphology0.81727287
97MP0003119_abnormal_digestive_system0.80829244
98MP0004085_abnormal_heartbeat0.78543992
99MP0002138_abnormal_hepatobiliary_system0.76484606
100MP0004043_abnormal_pH_regulation0.74704381

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.32414338
2Pancreatic fibrosis (HP:0100732)4.00951390
3Absent/shortened dynein arms (HP:0200106)3.81835003
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.81835003
5Molar tooth sign on MRI (HP:0002419)3.59984940
6Abnormality of midbrain morphology (HP:0002418)3.59984940
7Abnormal rod and cone electroretinograms (HP:0008323)3.40557552
8Reticulocytopenia (HP:0001896)3.36593021
9Nephronophthisis (HP:0000090)3.08153160
10Pancreatic cysts (HP:0001737)3.05889897
11Abnormality of the labia minora (HP:0012880)3.01178494
12Hyperventilation (HP:0002883)2.93267498
13True hermaphroditism (HP:0010459)2.84021665
14Abnormal respiratory epithelium morphology (HP:0012253)2.79022668
15Abnormal respiratory motile cilium morphology (HP:0005938)2.79022668
16Cystic liver disease (HP:0006706)2.74300753
17Anencephaly (HP:0002323)2.66365347
18Pendular nystagmus (HP:0012043)2.58235355
19Progressive cerebellar ataxia (HP:0002073)2.55905259
20Chronic hepatic failure (HP:0100626)2.53466898
21Abnormality of the renal medulla (HP:0100957)2.52419422
22Pachygyria (HP:0001302)2.51181980
23Abnormal ciliary motility (HP:0012262)2.45724478
24Medial flaring of the eyebrow (HP:0010747)2.44410093
25Pallor (HP:0000980)2.41905933
26Sclerocornea (HP:0000647)2.41674832
27Acute necrotizing encephalopathy (HP:0006965)2.41549631
28Rib fusion (HP:0000902)2.40468859
29Bony spicule pigmentary retinopathy (HP:0007737)2.39931594
30Lissencephaly (HP:0001339)2.39629736
31Decreased central vision (HP:0007663)2.36916764
32Colon cancer (HP:0003003)2.35467944
33Congenital stationary night blindness (HP:0007642)2.35093000
34Abnormality of cells of the erythroid lineage (HP:0012130)2.34905308
35Abnormality of the 4th metacarpal (HP:0010012)2.31052622
36Short 4th metacarpal (HP:0010044)2.29726679
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29726679
38Macrocytic anemia (HP:0001972)2.28087327
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.25509240
40Asplenia (HP:0001746)2.25313556
41Focal motor seizures (HP:0011153)2.25251178
42Stenosis of the external auditory canal (HP:0000402)2.23347356
43Epileptic encephalopathy (HP:0200134)2.18248411
44Lipid accumulation in hepatocytes (HP:0006561)2.17445978
45Acute encephalopathy (HP:0006846)2.14447054
46Dyskinesia (HP:0100660)2.13229574
47Type II lissencephaly (HP:0007260)2.12153136
48Status epilepticus (HP:0002133)2.10894702
49Bile duct proliferation (HP:0001408)2.10421175
50Abnormal biliary tract physiology (HP:0012439)2.10421175
51Increased hepatocellular lipid droplets (HP:0006565)2.10347877
52Abnormality of the renal cortex (HP:0011035)2.09615547
53Postaxial foot polydactyly (HP:0001830)2.09536341
54Mitochondrial inheritance (HP:0001427)2.08775606
55Septo-optic dysplasia (HP:0100842)2.07772115
56Abnormal respiratory motile cilium physiology (HP:0012261)2.06958783
57Myokymia (HP:0002411)2.06869200
58Progressive macrocephaly (HP:0004481)2.06161868
59Abnormal mitochondria in muscle tissue (HP:0008316)2.05347109
60Shawl scrotum (HP:0000049)2.04077851
61Anophthalmia (HP:0000528)2.03224192
62Focal seizures (HP:0007359)2.01951170
63Absent thumb (HP:0009777)2.01701862
64Gait imbalance (HP:0002141)2.00082609
65Abolished electroretinogram (ERG) (HP:0000550)1.95668163
66Genital tract atresia (HP:0001827)1.95354188
67Polydipsia (HP:0001959)1.93244203
68Abnormal drinking behavior (HP:0030082)1.93244203
693-Methylglutaconic aciduria (HP:0003535)1.93056725
70Hyperglycinemia (HP:0002154)1.92538075
71Nephrogenic diabetes insipidus (HP:0009806)1.86957215
72Aplasia/Hypoplasia of the patella (HP:0006498)1.84377941
73Patellar aplasia (HP:0006443)1.84305416
74Polyphagia (HP:0002591)1.84152675
75Increased CSF lactate (HP:0002490)1.83722651
76Vaginal atresia (HP:0000148)1.82109595
77Renal cortical cysts (HP:0000803)1.81560966
78Congenital primary aphakia (HP:0007707)1.81187421
79Limb dystonia (HP:0002451)1.80824973
80Decreased circulating renin level (HP:0003351)1.80693533
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80146055
82Preaxial hand polydactyly (HP:0001177)1.79548780
83Hypoplasia of the ulna (HP:0003022)1.78177343
84Renal Fanconi syndrome (HP:0001994)1.75864331
85Occipital encephalocele (HP:0002085)1.75094521
86Postaxial hand polydactyly (HP:0001162)1.73583013
87Abnormal number of erythroid precursors (HP:0012131)1.73430199
88Retinal dysplasia (HP:0007973)1.71509391
89Abnormality of renal resorption (HP:0011038)1.70213092
90Congenital hepatic fibrosis (HP:0002612)1.70079369
91Agitation (HP:0000713)1.69823165
92Abnormality of urine glucose concentration (HP:0011016)1.68423374
93Glycosuria (HP:0003076)1.68423374
94Small hand (HP:0200055)1.66649768
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66193556
96Hypoplasia of the brainstem (HP:0002365)1.66193556
97Optic nerve hypoplasia (HP:0000609)1.65924907
98Broad-based gait (HP:0002136)1.65713605
99Optic disc pallor (HP:0000543)1.64940749
100Triphalangeal thumb (HP:0001199)1.64615777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.20115736
2TLK13.18881586
3WNK43.07088455
4MAP4K22.75720624
5WNK32.57155884
6ZAK2.41176527
7TXK2.40101726
8BMPR1B2.33805944
9STK392.19016462
10CDC72.08521282
11MARK11.94851896
12NUAK11.92254954
13GRK11.83833273
14GRK71.82126294
15DYRK21.65385319
16FGFR21.64275726
17ADRBK21.62537760
18TGFBR21.58620919
19MAPK131.54270134
20PIK3CA1.53753243
21PINK11.52794189
22TNIK1.52668106
23CAMKK21.43422219
24CASK1.33720243
25EPHB21.28696585
26TYRO31.28063140
27INSRR1.27450336
28PAK31.26009093
29STK161.19211069
30BCKDK1.18594008
31SGK21.16767977
32SGK4941.16617165
33SGK2231.16617165
34TAOK11.16041069
35CDK191.15042435
36AKT31.10948104
37OXSR11.10302363
38CAMK11.09528079
39NTRK21.05662454
40PRKCG1.02651529
41CAMKK10.98781960
42STK110.98612080
43SIK20.98013300
44MAP3K110.97071531
45MINK10.94665592
46DAPK20.92793335
47VRK10.92692517
48ADRBK10.91350933
49MAP2K70.90258138
50PRKCQ0.88932752
51TIE10.88060130
52MAPK150.86635347
53VRK20.86551318
54PLK10.85798791
55NEK20.84820931
56EPHA40.84501478
57BRAF0.81067586
58PRKACA0.76483759
59MAP3K40.75505663
60LATS10.72407615
61CSNK1G20.69477842
62PLK40.69126986
63RPS6KA60.67442356
64NTRK30.65554561
65PRKCZ0.65054174
66DYRK30.63054649
67CAMK40.62680443
68PHKG20.62363333
69PHKG10.62363333
70PKN10.62258070
71MKNK20.61944826
72SGK10.61528721
73TAOK30.60873170
74GRK50.60098891
75MUSK0.59895167
76CSNK1G30.58291869
77AURKB0.57163240
78NEK10.55605809
79CAMK2A0.54365834
80RPS6KA20.54214051
81PNCK0.54028207
82NME10.52907921
83RPS6KA50.51546443
84AURKA0.51366054
85DYRK1A0.50693148
86SGK30.50318009
87PAK60.48769151
88ACVR1B0.46327172
89RPS6KC10.46032065
90RPS6KL10.46032065
91STK30.43282110
92CSNK1A10.42822816
93PDK20.42660970
94CSNK1A1L0.41616450
95PRKCA0.38944196
96CAMK1G0.38909496
97PLK20.38174458
98OBSCN0.37942282
99ATR0.37723863
100CSNK1G10.36791072

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.79084022
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.81977803
3Sulfur relay system_Homo sapiens_hsa041223.03449425
4Oxidative phosphorylation_Homo sapiens_hsa001902.92564648
5Phototransduction_Homo sapiens_hsa047442.87509438
6Linoleic acid metabolism_Homo sapiens_hsa005912.61152119
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.33852270
8Homologous recombination_Homo sapiens_hsa034402.31024548
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20160853
10Caffeine metabolism_Homo sapiens_hsa002322.16850043
11Parkinsons disease_Homo sapiens_hsa050122.12769204
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09035817
13Cardiac muscle contraction_Homo sapiens_hsa042602.02981280
14Nitrogen metabolism_Homo sapiens_hsa009101.96147094
15Ether lipid metabolism_Homo sapiens_hsa005651.88878700
16Protein export_Homo sapiens_hsa030601.83322862
17Nicotine addiction_Homo sapiens_hsa050331.78097056
18Huntingtons disease_Homo sapiens_hsa050161.67345014
19RNA polymerase_Homo sapiens_hsa030201.65587182
20Fanconi anemia pathway_Homo sapiens_hsa034601.52096646
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46816527
22Alzheimers disease_Homo sapiens_hsa050101.46519802
23RNA degradation_Homo sapiens_hsa030181.43766906
24Tryptophan metabolism_Homo sapiens_hsa003801.42464577
25Basal transcription factors_Homo sapiens_hsa030221.40025211
26Folate biosynthesis_Homo sapiens_hsa007901.39048789
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35995309
28Morphine addiction_Homo sapiens_hsa050321.33766722
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25427328
30Olfactory transduction_Homo sapiens_hsa047401.24710780
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22771952
32Insulin secretion_Homo sapiens_hsa049111.20557853
33Retinol metabolism_Homo sapiens_hsa008301.19047612
34Peroxisome_Homo sapiens_hsa041461.12174825
35Glutamatergic synapse_Homo sapiens_hsa047240.98945143
36Mismatch repair_Homo sapiens_hsa034300.98898033
37Arachidonic acid metabolism_Homo sapiens_hsa005900.98340488
38Vitamin digestion and absorption_Homo sapiens_hsa049770.98245748
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94428519
40Chemical carcinogenesis_Homo sapiens_hsa052040.94424866
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.93843981
42Serotonergic synapse_Homo sapiens_hsa047260.90984626
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90512402
44Asthma_Homo sapiens_hsa053100.88678018
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.87852347
46Circadian entrainment_Homo sapiens_hsa047130.87069282
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.84863930
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82038387
49Nucleotide excision repair_Homo sapiens_hsa034200.81889413
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78573253
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78266714
52Propanoate metabolism_Homo sapiens_hsa006400.77078404
53Fat digestion and absorption_Homo sapiens_hsa049750.76862483
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75323203
55Cholinergic synapse_Homo sapiens_hsa047250.75253753
56Dopaminergic synapse_Homo sapiens_hsa047280.73788419
57One carbon pool by folate_Homo sapiens_hsa006700.73133825
58Taste transduction_Homo sapiens_hsa047420.69772529
59Ovarian steroidogenesis_Homo sapiens_hsa049130.68548458
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68383284
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.67748009
62Basal cell carcinoma_Homo sapiens_hsa052170.61036446
63Steroid biosynthesis_Homo sapiens_hsa001000.60751138
64Selenocompound metabolism_Homo sapiens_hsa004500.60163653
65Butanoate metabolism_Homo sapiens_hsa006500.58288333
66Non-homologous end-joining_Homo sapiens_hsa034500.56875829
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56274799
68GABAergic synapse_Homo sapiens_hsa047270.55405818
69Long-term depression_Homo sapiens_hsa047300.54447739
70Pyrimidine metabolism_Homo sapiens_hsa002400.53539821
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.53181788
72Metabolic pathways_Homo sapiens_hsa011000.52410521
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52325603
74Salivary secretion_Homo sapiens_hsa049700.51986791
75Glycerolipid metabolism_Homo sapiens_hsa005610.51520992
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51471506
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51351793
78Oxytocin signaling pathway_Homo sapiens_hsa049210.48693143
79Autoimmune thyroid disease_Homo sapiens_hsa053200.47615765
80Purine metabolism_Homo sapiens_hsa002300.47274677
81Proteasome_Homo sapiens_hsa030500.47191994
82Hedgehog signaling pathway_Homo sapiens_hsa043400.46072469
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.45219759
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43026625
85Axon guidance_Homo sapiens_hsa043600.42764907
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42084126
87Hippo signaling pathway_Homo sapiens_hsa043900.39179171
88Allograft rejection_Homo sapiens_hsa053300.38757283
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36597015
90Primary immunodeficiency_Homo sapiens_hsa053400.36538309
91Systemic lupus erythematosus_Homo sapiens_hsa053220.35963352
92Gastric acid secretion_Homo sapiens_hsa049710.32637744
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32501124
94Calcium signaling pathway_Homo sapiens_hsa040200.31031939
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30894671
96Dorso-ventral axis formation_Homo sapiens_hsa043200.29981081
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28913806
98ABC transporters_Homo sapiens_hsa020100.28527224
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27595619
100Base excision repair_Homo sapiens_hsa034100.27020807

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