RPL29P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.51837119
2nucleotide transmembrane transport (GO:1901679)5.85276110
3negative regulation of protein oligomerization (GO:0032460)5.63681370
4cytidine metabolic process (GO:0046087)5.12745103
5cytidine catabolic process (GO:0006216)5.12745103
6cytidine deamination (GO:0009972)5.12745103
7maturation of 5.8S rRNA (GO:0000460)4.88585967
8T-helper 1 type immune response (GO:0042088)4.48230942
9protein-cofactor linkage (GO:0018065)4.33165320
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.20115071
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.12654364
12protein import into peroxisome matrix (GO:0016558)3.86764626
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.70680650
14ATP synthesis coupled proton transport (GO:0015986)3.70680650
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60096880
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52900780
17ribosomal small subunit assembly (GO:0000028)3.51415867
18response to interferon-beta (GO:0035456)3.50881567
19positive regulation of T cell mediated cytotoxicity (GO:0001916)3.50427416
20regulation of protein homooligomerization (GO:0032462)3.38954112
21nucleotide transport (GO:0006862)3.37392901
22microglial cell activation (GO:0001774)3.29540817
23regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.27929452
24nephron tubule formation (GO:0072079)3.25213854
25cytolysis (GO:0019835)3.18506060
26iron-sulfur cluster assembly (GO:0016226)3.16121593
27metallo-sulfur cluster assembly (GO:0031163)3.16121593
28negative regulation of telomere maintenance (GO:0032205)3.15042752
29behavioral response to nicotine (GO:0035095)3.14167199
30respiratory electron transport chain (GO:0022904)3.13597759
31electron transport chain (GO:0022900)3.13485891
32regulation of activation of Janus kinase activity (GO:0010533)3.08927314
33rRNA catabolic process (GO:0016075)3.07790371
34regulation of T cell mediated cytotoxicity (GO:0001914)3.06092078
35regulation of isotype switching to IgG isotypes (GO:0048302)3.01961517
36neuron fate determination (GO:0048664)2.99493975
37sequestering of actin monomers (GO:0042989)2.96478046
38nephron tubule morphogenesis (GO:0072078)2.94424599
39nephron epithelium morphogenesis (GO:0072088)2.94424599
40spliceosomal snRNP assembly (GO:0000387)2.93448086
41water-soluble vitamin biosynthetic process (GO:0042364)2.92954580
42viral transcription (GO:0019083)2.92923300
43macrophage chemotaxis (GO:0048246)2.87441862
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84239396
45positive regulation of B cell differentiation (GO:0045579)2.82860245
46cellular response to interferon-beta (GO:0035458)2.81356809
47negative regulation of mast cell activation (GO:0033004)2.80882087
48intracellular protein transmembrane import (GO:0044743)2.79794884
49indolalkylamine metabolic process (GO:0006586)2.79508068
50establishment of protein localization to peroxisome (GO:0072663)2.77772083
51protein localization to peroxisome (GO:0072662)2.77772083
52protein targeting to peroxisome (GO:0006625)2.77772083
53cilium or flagellum-dependent cell motility (GO:0001539)2.76875473
54platelet dense granule organization (GO:0060155)2.76395923
55lipopolysaccharide biosynthetic process (GO:0009103)2.76311965
56positive regulation of interleukin-17 production (GO:0032740)2.75837048
57positive regulation of defense response to virus by host (GO:0002230)2.75105083
58protein complex biogenesis (GO:0070271)2.72489740
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70935208
60ribosomal small subunit biogenesis (GO:0042274)2.70275289
61translational termination (GO:0006415)2.69402630
62sulfation (GO:0051923)2.68627177
63negative regulation of execution phase of apoptosis (GO:1900118)2.68167015
64cornea development in camera-type eye (GO:0061303)2.65781092
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62553090
66positive thymic T cell selection (GO:0045059)2.61671965
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.60818296
68actin nucleation (GO:0045010)2.60023042
69regulation of respiratory gaseous exchange (GO:0043576)2.58307170
70positive regulation of isotype switching (GO:0045830)2.55678850
71translational elongation (GO:0006414)2.55574657
72ATP biosynthetic process (GO:0006754)2.52258322
73regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52067131
74positive regulation of interleukin-8 secretion (GO:2000484)2.52063680
75regulation of B cell receptor signaling pathway (GO:0050855)2.50612696
76positive T cell selection (GO:0043368)2.50509739
77DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.50064253
78adaptation of signaling pathway (GO:0023058)2.49179302
79regulation of T cell receptor signaling pathway (GO:0050856)2.48305181
80cell proliferation in forebrain (GO:0021846)2.46547826
81response to xenobiotic stimulus (GO:0009410)2.46423984
82interferon-gamma secretion (GO:0072643)2.45749728
83histone H4-K12 acetylation (GO:0043983)2.44076727
84negative regulation of viral genome replication (GO:0045071)2.43670525
85mast cell activation involved in immune response (GO:0002279)2.43051161
86mast cell degranulation (GO:0043303)2.43051161
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.41758897
88DNA damage response, signal transduction resulting in transcription (GO:0042772)2.41731875
89primary amino compound metabolic process (GO:1901160)2.41180623
90lipopolysaccharide metabolic process (GO:0008653)2.40373154
91regulation of mitochondrial translation (GO:0070129)2.39878049
92peroxisomal transport (GO:0043574)2.39712444
93negative regulation of cell killing (GO:0031342)2.39397242
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39397242
95positive regulation of T cell mediated immunity (GO:0002711)2.39325862
96glycerophospholipid catabolic process (GO:0046475)2.36637102
97regulation of leukocyte mediated cytotoxicity (GO:0001910)2.35830628
98establishment of protein localization to mitochondrial membrane (GO:0090151)2.35239761
99cellular protein complex disassembly (GO:0043624)2.34772918
100serotonin metabolic process (GO:0042428)2.34539434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14189046
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12994656
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38097506
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98598332
5VDR_22108803_ChIP-Seq_LS180_Human2.87809741
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85390588
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.80333774
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75022346
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.51612426
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49057859
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.47195131
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37163582
13IGF1R_20145208_ChIP-Seq_DFB_Human1.99856593
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82082573
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80636251
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.80195498
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79069313
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.72989849
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71310477
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70680509
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70534275
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70086840
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69797132
24RNF2_27304074_Chip-Seq_NSC_Mouse1.63443725
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59439502
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58993862
27TDRD3_21172665_ChIP-Seq_MCF-7_Human1.58367498
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57757454
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.57593298
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.54559429
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52469693
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.51297032
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.51174757
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49160880
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.48769585
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48560273
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.48560273
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47843524
39NANOG_20526341_ChIP-Seq_ESCs_Human1.46859262
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46070148
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44812956
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44812956
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.44461196
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43866466
45ERA_21632823_ChIP-Seq_H3396_Human1.42001115
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41546365
47MYC_19829295_ChIP-Seq_ESCs_Human1.38975463
48IRF1_19129219_ChIP-ChIP_H3396_Human1.38432437
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36685541
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35701543
51TAF2_19829295_ChIP-Seq_ESCs_Human1.35497929
52AR_21572438_ChIP-Seq_LNCaP_Human1.33136352
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32551173
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.31547053
55HTT_18923047_ChIP-ChIP_STHdh_Human1.29359428
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26143341
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26135297
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25454363
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25310173
60TP53_22573176_ChIP-Seq_HFKS_Human1.24524670
61NANOG_19829295_ChIP-Seq_ESCs_Human1.23531504
62SOX2_19829295_ChIP-Seq_ESCs_Human1.23531504
63P300_19829295_ChIP-Seq_ESCs_Human1.23118369
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22935757
65AR_20517297_ChIP-Seq_VCAP_Human1.22727073
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20969978
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.20622226
68GBX2_23144817_ChIP-Seq_PC3_Human1.18675440
69BCL6_27268052_Chip-Seq_Bcells_Human1.18370511
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18308656
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.16517429
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15299621
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14719020
74NCOR_22424771_ChIP-Seq_293T_Human1.14539317
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.14148818
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12328537
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08870336
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.07931639
79P53_21459846_ChIP-Seq_SAOS-2_Human1.07613336
80E2F1_20622854_ChIP-Seq_HELA_Human1.07522149
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.05052073
82SA1_27219007_Chip-Seq_Bcells_Human1.04350921
83VDR_23849224_ChIP-Seq_CD4+_Human1.03409063
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02947637
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00306116
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.99913045
87RAC3_21632823_ChIP-Seq_H3396_Human0.99763045
88TAF15_26573619_Chip-Seq_HEK293_Human0.99725880
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99422950
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99336509
91REST_21632747_ChIP-Seq_MESCs_Mouse0.98883147
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97421641
93RNF2_27304074_Chip-Seq_ESCs_Mouse0.97140700
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96416361
95SMRT_27268052_Chip-Seq_Bcells_Human0.95893219
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94326472
97CTCF_20526341_ChIP-Seq_ESCs_Human0.94323770
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93223666
99GATA3_27048872_Chip-Seq_THYMUS_Human0.90872645
100ERG_20517297_ChIP-Seq_VCAP_Human0.90105817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.24337390
2MP0006082_CNS_inflammation4.50961957
3MP0005671_abnormal_response_to3.72661641
4MP0001873_stomach_inflammation3.49507525
5MP0006292_abnormal_olfactory_placode2.83569690
6MP0002102_abnormal_ear_morphology2.77208693
7MP0002277_abnormal_respiratory_mucosa2.54175648
8MP0000372_irregular_coat_pigmentation2.45477910
9MP0002876_abnormal_thyroid_physiology2.35835219
10MP0008875_abnormal_xenobiotic_pharmacok2.19975812
11MP0005645_abnormal_hypothalamus_physiol2.18532157
12MP0000685_abnormal_immune_system2.12574431
13MP0009785_altered_susceptibility_to2.09554261
14MP0002822_catalepsy2.08871408
15MP0001905_abnormal_dopamine_level2.08633032
16MP0003011_delayed_dark_adaptation2.06700971
17MP0002132_abnormal_respiratory_system2.02713743
18MP0010386_abnormal_urinary_bladder2.02411716
19MP0005084_abnormal_gallbladder_morpholo1.97687548
20MP0005389_reproductive_system_phenotype1.95751851
21MP0002837_dystrophic_cardiac_calcinosis1.86792187
22MP0001919_abnormal_reproductive_system1.85553078
23MP0003195_calcinosis1.72508852
24MP0006072_abnormal_retinal_apoptosis1.70405837
25MP0002160_abnormal_reproductive_system1.59777548
26MP0003646_muscle_fatigue1.54392881
27MP0004147_increased_porphyrin_level1.48951156
28MP0003763_abnormal_thymus_physiology1.47700158
29MP0001348_abnormal_lacrimal_gland1.44495512
30MP0002138_abnormal_hepatobiliary_system1.44222047
31MP0005646_abnormal_pituitary_gland1.43368380
32MP0005025_abnormal_response_to1.36458375
33MP0000631_abnormal_neuroendocrine_gland1.33949443
34MP0009379_abnormal_foot_pigmentation1.32172432
35MP0003866_abnormal_defecation1.26880244
36MP0003880_abnormal_central_pattern1.26231436
37MP0005551_abnormal_eye_electrophysiolog1.26169164
38MP0003879_abnormal_hair_cell1.14547445
39MP0001663_abnormal_digestive_system1.11457545
40MP0001986_abnormal_taste_sensitivity1.10791611
41MP0002653_abnormal_ependyma_morphology1.09524010
42MP0005360_urolithiasis1.07574086
43MP0005000_abnormal_immune_tolerance1.06576982
44MP0002928_abnormal_bile_duct1.05611662
45MP0001346_abnormal_lacrimal_gland1.05403630
46MP0009333_abnormal_splenocyte_physiolog1.05115753
47MP0006276_abnormal_autonomic_nervous1.05046949
48MP0001800_abnormal_humoral_immune1.04389044
49MP0005166_decreased_susceptibility_to1.03947820
50MP0002148_abnormal_hypersensitivity_rea1.02992544
51MP0005423_abnormal_somatic_nervous1.01979308
52MP0004019_abnormal_vitamin_homeostasis1.00858342
53MP0001968_abnormal_touch/_nociception1.00364183
54MP0002723_abnormal_immune_serum0.99806525
55MP0005085_abnormal_gallbladder_physiolo0.99523137
56MP0004145_abnormal_muscle_electrophysio0.99414564
57MP0003938_abnormal_ear_development0.98968604
58MP0004142_abnormal_muscle_tone0.98005705
59MP0001790_abnormal_immune_system0.96932448
60MP0005387_immune_system_phenotype0.96932448
61MP0000049_abnormal_middle_ear0.96354962
62MP0003252_abnormal_bile_duct0.95672905
63MP0009745_abnormal_behavioral_response0.94988887
64MP0002693_abnormal_pancreas_physiology0.94677128
65MP0008872_abnormal_physiological_respon0.94253747
66MP0002163_abnormal_gland_morphology0.94031774
67MP0008877_abnormal_DNA_methylation0.93266719
68MP0005253_abnormal_eye_physiology0.92249927
69MP0005410_abnormal_fertilization0.91885160
70MP0002272_abnormal_nervous_system0.91471086
71MP0004885_abnormal_endolymph0.89732087
72MP0001835_abnormal_antigen_presentation0.88080951
73MP0001119_abnormal_female_reproductive0.87757720
74MP0002420_abnormal_adaptive_immunity0.87158529
75MP0002452_abnormal_antigen_presenting0.86553863
76MP0002638_abnormal_pupillary_reflex0.86273801
77MP0009046_muscle_twitch0.85866986
78MP0005377_hearing/vestibular/ear_phenot0.85541711
79MP0003878_abnormal_ear_physiology0.85541711
80MP0005647_abnormal_sex_gland0.84171383
81MP0001819_abnormal_immune_cell0.81349176
82MP0004133_heterotaxia0.80920345
83MP0002933_joint_inflammation0.79957067
84MP0002405_respiratory_system_inflammati0.79745976
85MP0003724_increased_susceptibility_to0.78488014
86MP0000026_abnormal_inner_ear0.77663636
87MP0001485_abnormal_pinna_reflex0.74778225
88MP0002095_abnormal_skin_pigmentation0.73175952
89MP0002736_abnormal_nociception_after0.71478505
90MP0003786_premature_aging0.71226995
91MP0003136_yellow_coat_color0.70547596
92MP0001764_abnormal_homeostasis0.69647357
93MP0005636_abnormal_mineral_homeostasis0.69564439
94MP0003950_abnormal_plasma_membrane0.67537046
95MP0005195_abnormal_posterior_eye0.66931533
96MP0002064_seizures0.66013450
97MP0003690_abnormal_glial_cell0.65589603
98MP0005503_abnormal_tendon_morphology0.65023201
99MP0008995_early_reproductive_senescence0.64732389
100MP0002572_abnormal_emotion/affect_behav0.64647739

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)4.50985831
2Aplastic anemia (HP:0001915)3.57871765
3Stomatitis (HP:0010280)3.45444044
4Abnormal finger flexion creases (HP:0006143)3.35331102
5Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.11576619
6Humeroradial synostosis (HP:0003041)3.07630116
7Synostosis involving the elbow (HP:0003938)3.07630116
8Hypothermia (HP:0002045)3.05688754
9Polydipsia (HP:0001959)3.03357911
10Abnormal drinking behavior (HP:0030082)3.03357911
11Delayed closure of the anterior fontanelle (HP:0001476)2.96337926
12Brushfield spots (HP:0001088)2.91864874
13Abnormality of B cell number (HP:0010975)2.90401367
14Tetany (HP:0001281)2.87035296
15Increased hepatocellular lipid droplets (HP:0006565)2.86412949
16Hypomagnesemia (HP:0002917)2.83842013
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.83105210
18Methylmalonic acidemia (HP:0002912)2.72344061
19Mitochondrial inheritance (HP:0001427)2.70311305
20Radial bowing (HP:0002986)2.69784827
21Autoimmune thrombocytopenia (HP:0001973)2.68987716
22Abnormality of the prostate (HP:0008775)2.62441634
23True hermaphroditism (HP:0010459)2.60213478
24Symphalangism affecting the phalanges of the hand (HP:0009773)2.59286827
25Congenital stationary night blindness (HP:0007642)2.58035374
26Aplasia/hypoplasia of the uterus (HP:0008684)2.56358757
27Thyroid-stimulating hormone excess (HP:0002925)2.55247479
28Acute necrotizing encephalopathy (HP:0006965)2.53831934
29Increased intramyocellular lipid droplets (HP:0012240)2.53131899
30Lipid accumulation in hepatocytes (HP:0006561)2.51670885
31Abnormal number of erythroid precursors (HP:0012131)2.51174340
32Abnormality of magnesium homeostasis (HP:0004921)2.45720869
33Nasal polyposis (HP:0100582)2.42981567
34Abnormal mitochondria in muscle tissue (HP:0008316)2.42760778
35Increased CSF lactate (HP:0002490)2.41547300
36Constricted visual fields (HP:0001133)2.39685692
37Renal Fanconi syndrome (HP:0001994)2.38964291
38Elevated erythrocyte sedimentation rate (HP:0003565)2.37491974
39Keratoconus (HP:0000563)2.36343876
40Increased corneal curvature (HP:0100692)2.36343876
41Medial flaring of the eyebrow (HP:0010747)2.35872541
42Asplenia (HP:0001746)2.33385193
43Absent phalangeal crease (HP:0006109)2.33017057
44Methylmalonic aciduria (HP:0012120)2.28454718
45Aplasia/Hypoplasia of the fibula (HP:0006492)2.26149763
46Pancreatic cysts (HP:0001737)2.25716694
47Chronic diarrhea (HP:0002028)2.23512616
48Abolished electroretinogram (ERG) (HP:0000550)2.23421056
49Exertional dyspnea (HP:0002875)2.23201894
50Flat occiput (HP:0005469)2.22012170
51Decreased central vision (HP:0007663)2.21156869
52Oral leukoplakia (HP:0002745)2.19518126
53Pendular nystagmus (HP:0012043)2.18637696
54Aplasia/Hypoplasia of the patella (HP:0006498)2.16677871
55Abnormality of male internal genitalia (HP:0000022)2.16454081
56Concave nail (HP:0001598)2.16012288
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.15671372
58Patellar aplasia (HP:0006443)2.14575530
59Polyuria (HP:0000103)2.14146115
60Split foot (HP:0001839)2.11575774
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10639131
62Abnormal ciliary motility (HP:0012262)2.09626502
63Hypoproteinemia (HP:0003075)2.07956206
64Hypoplastic iliac wings (HP:0002866)2.04877160
65Abnormality of cells of the erythroid lineage (HP:0012130)2.04469388
66Cerebellar dysplasia (HP:0007033)2.03699283
67Acute encephalopathy (HP:0006846)2.02081752
68Increased muscle lipid content (HP:0009058)2.01844416
69Abnormality of T cell number (HP:0011839)2.01529990
70Adactyly (HP:0009776)1.98975192
71Abnormality of urine glucose concentration (HP:0011016)1.98005033
72Glycosuria (HP:0003076)1.98005033
73Respiratory distress (HP:0002098)1.97424524
74Abnormal rod and cone electroretinograms (HP:0008323)1.96777340
75Progressive macrocephaly (HP:0004481)1.95461854
76Morphological abnormality of the middle ear (HP:0008609)1.94013722
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93975485
78Abnormal respiratory motile cilium physiology (HP:0012261)1.93769999
79Ureteral obstruction (HP:0006000)1.92800439
80Type II lissencephaly (HP:0007260)1.92297849
81Abnormality of the nasal mucosa (HP:0000433)1.91812496
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.90596174
83Abnormality of the pubic bones (HP:0003172)1.90448824
84Lymphopenia (HP:0001888)1.89819949
85Attenuation of retinal blood vessels (HP:0007843)1.88859622
86Hepatocellular necrosis (HP:0001404)1.88501539
87Abnormality of cells of the lymphoid lineage (HP:0012140)1.87393057
88Chronic mucocutaneous candidiasis (HP:0002728)1.87063662
89Recurrent cutaneous fungal infections (HP:0011370)1.87063662
90Decreased circulating renin level (HP:0003351)1.86202386
91Abnormality of vitamin B metabolism (HP:0004340)1.83674588
92Oligodactyly (hands) (HP:0001180)1.82616982
93Severe combined immunodeficiency (HP:0004430)1.81057840
94Macrocytic anemia (HP:0001972)1.80501259
95Abnormal urine output (HP:0012590)1.79332376
96IgG deficiency (HP:0004315)1.77869403
97Chronic bronchitis (HP:0004469)1.76308651
98Optic disc pallor (HP:0000543)1.75774217
99Abnormality of T cells (HP:0002843)1.74528320
100Abnormal respiratory epithelium morphology (HP:0012253)1.74167720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.33344949
2MAP3K94.04282711
3PASK3.80250799
4TXK2.88965934
5KDR2.72171754
6TESK22.44613947
7VRK12.43629068
8VRK22.37235212
9ITK2.35008249
10TAF12.31967750
11TLK12.23417066
12TAOK32.13755116
13MAP3K132.08973616
14ADRBK22.02932145
15MARK11.87577311
16TSSK61.86978888
17PKN11.85484454
18NTRK21.83954861
19MUSK1.75444164
20MAP4K21.71518837
21ZAK1.67891348
22GRK11.65018604
23MAP4K11.64815730
24BCKDK1.35486959
25TEC1.29609704
26PNCK1.24753625
27FRK1.22620331
28CDK191.19957408
29WNK31.13044331
30SYK1.11974121
31IKBKB1.10665098
32RPS6KA51.10499673
33BTK1.04234333
34CAMKK11.03277384
35CSNK1G31.02725695
36CSK0.99623731
37MAP2K70.98337585
38WNK40.96902661
39INSRR0.96216819
40MAPKAPK30.94390674
41BMPR1B0.94310993
42CASK0.93063743
43MAP3K110.92749565
44CSNK1G10.91310509
45TYRO30.88719569
46CSNK1G20.88185339
47NUAK10.88132891
48STK160.83944244
49MAPK130.83151805
50TNK20.80070004
51AURKA0.76730183
52TBK10.75973784
53IKBKE0.74850619
54PIK3CG0.74718994
55KIT0.72179136
56FGR0.72082730
57PRKCQ0.71115966
58OBSCN0.69910879
59MAPKAPK50.69483621
60MAP3K140.67760217
61PINK10.65824233
62ABL20.65049000
63MAP3K70.64960682
64CHUK0.61671852
65DAPK30.58213187
66LCK0.55638888
67ERBB30.54663712
68MAP3K120.53234274
69CSF1R0.52173305
70CSNK1A1L0.52031097
71WEE10.51877956
72GRK70.50738525
73ADRBK10.49627934
74ABL10.48852316
75CHEK20.45017241
76LYN0.44238797
77GSK3A0.43338407
78FES0.41849978
79PRKACA0.41601691
80DYRK20.41120269
81LIMK10.41015095
82MAP3K50.40812893
83RPS6KA60.40651204
84TESK10.40571962
85CDK30.40492543
86MKNK10.40106283
87NTRK30.39996153
88MAP3K40.39864311
89CSNK1A10.39661476
90ZAP700.35850359
91PRKCA0.35185515
92PIM20.35082937
93MST40.29552196
94MAPK40.29142536
95CSNK2A10.28857945
96CSNK2A20.28071499
97PRKCE0.28035414
98MATK0.27731793
99TIE10.27645841
100PRKCG0.26404979

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.61787960
2Primary immunodeficiency_Homo sapiens_hsa053403.38398185
3Autoimmune thyroid disease_Homo sapiens_hsa053203.04829396
4Ribosome_Homo sapiens_hsa030102.98748954
5Parkinsons disease_Homo sapiens_hsa050122.97435105
6Graft-versus-host disease_Homo sapiens_hsa053322.93780075
7Allograft rejection_Homo sapiens_hsa053302.83152884
8Asthma_Homo sapiens_hsa053102.50812477
9Type I diabetes mellitus_Homo sapiens_hsa049402.34288495
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.34233595
11Antigen processing and presentation_Homo sapiens_hsa046122.20730742
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19701340
13Proteasome_Homo sapiens_hsa030502.18693495
14Alzheimers disease_Homo sapiens_hsa050102.08701019
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.98326325
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90049956
17Cardiac muscle contraction_Homo sapiens_hsa042601.88144974
18Huntingtons disease_Homo sapiens_hsa050161.82775647
19Systemic lupus erythematosus_Homo sapiens_hsa053221.77799885
20One carbon pool by folate_Homo sapiens_hsa006701.67118052
21Rheumatoid arthritis_Homo sapiens_hsa053231.64324789
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59932322
23Phototransduction_Homo sapiens_hsa047441.48341633
24RNA polymerase_Homo sapiens_hsa030201.47289559
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47035534
26Linoleic acid metabolism_Homo sapiens_hsa005911.44164554
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41360834
28Nitrogen metabolism_Homo sapiens_hsa009101.31598538
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28020781
30Hematopoietic cell lineage_Homo sapiens_hsa046401.27087578
31T cell receptor signaling pathway_Homo sapiens_hsa046601.25593578
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23735512
33Caffeine metabolism_Homo sapiens_hsa002321.12110031
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09781262
35Sulfur metabolism_Homo sapiens_hsa009201.06639182
36Vitamin digestion and absorption_Homo sapiens_hsa049771.05999322
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03254618
38Retinol metabolism_Homo sapiens_hsa008301.03091755
39Viral myocarditis_Homo sapiens_hsa054161.02083765
40Peroxisome_Homo sapiens_hsa041461.01977699
41Sulfur relay system_Homo sapiens_hsa041221.01422417
42Chemical carcinogenesis_Homo sapiens_hsa052040.97696851
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94912574
44RNA degradation_Homo sapiens_hsa030180.93285566
45Basal transcription factors_Homo sapiens_hsa030220.88328545
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85614684
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84602392
48Collecting duct acid secretion_Homo sapiens_hsa049660.83888902
49Staphylococcus aureus infection_Homo sapiens_hsa051500.82934853
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82627774
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82036826
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.80358734
53Protein export_Homo sapiens_hsa030600.78306307
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77931881
55Homologous recombination_Homo sapiens_hsa034400.76549174
56Leishmaniasis_Homo sapiens_hsa051400.74998115
57Nicotine addiction_Homo sapiens_hsa050330.73728572
58Arachidonic acid metabolism_Homo sapiens_hsa005900.72119258
59Olfactory transduction_Homo sapiens_hsa047400.71678161
60Fanconi anemia pathway_Homo sapiens_hsa034600.69718270
61Tryptophan metabolism_Homo sapiens_hsa003800.67461862
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65929991
63Taste transduction_Homo sapiens_hsa047420.65011610
64Alcoholism_Homo sapiens_hsa050340.65009281
65Hedgehog signaling pathway_Homo sapiens_hsa043400.60377349
66Mineral absorption_Homo sapiens_hsa049780.60068056
67Malaria_Homo sapiens_hsa051440.57609725
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.55489952
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.51686192
70Folate biosynthesis_Homo sapiens_hsa007900.50391372
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48843823
72B cell receptor signaling pathway_Homo sapiens_hsa046620.47059519
73Ether lipid metabolism_Homo sapiens_hsa005650.43896142
74Basal cell carcinoma_Homo sapiens_hsa052170.42436550
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42412566
76Epstein-Barr virus infection_Homo sapiens_hsa051690.42092171
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41761005
78Salmonella infection_Homo sapiens_hsa051320.41056101
79Tyrosine metabolism_Homo sapiens_hsa003500.39763126
80Herpes simplex infection_Homo sapiens_hsa051680.39292973
81Purine metabolism_Homo sapiens_hsa002300.38210992
82Ovarian steroidogenesis_Homo sapiens_hsa049130.36862680
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.33313710
84Metabolic pathways_Homo sapiens_hsa011000.32648926
85African trypanosomiasis_Homo sapiens_hsa051430.32373579
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.30868021
87Morphine addiction_Homo sapiens_hsa050320.30540271
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30536898
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29849530
90Regulation of autophagy_Homo sapiens_hsa041400.29346893
91Pyrimidine metabolism_Homo sapiens_hsa002400.28700211
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28279152
93Salivary secretion_Homo sapiens_hsa049700.28134875
94Serotonergic synapse_Homo sapiens_hsa047260.26677395
95Circadian entrainment_Homo sapiens_hsa047130.25997176
96Legionellosis_Homo sapiens_hsa051340.25630409
97Pertussis_Homo sapiens_hsa051330.24704557
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23854774
99Fat digestion and absorption_Homo sapiens_hsa049750.23667625
100Measles_Homo sapiens_hsa051620.22733143

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