RPL29P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.95644719
2ribosomal small subunit assembly (GO:0000028)5.76994366
3viral transcription (GO:0019083)5.40692735
4chaperone-mediated protein transport (GO:0072321)5.26013058
5translational termination (GO:0006415)5.13475740
6behavioral response to nicotine (GO:0035095)5.03152012
7DNA deamination (GO:0045006)4.94848628
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.66455271
9cotranslational protein targeting to membrane (GO:0006613)4.62237501
10water-soluble vitamin biosynthetic process (GO:0042364)4.60215944
11protein targeting to ER (GO:0045047)4.57244461
12ATP synthesis coupled proton transport (GO:0015986)4.43564350
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43564350
14translational elongation (GO:0006414)4.35693592
15protein localization to endoplasmic reticulum (GO:0070972)4.35608077
16ribosomal small subunit biogenesis (GO:0042274)4.34570895
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.32656220
18peptidyl-histidine modification (GO:0018202)4.27774168
19preassembly of GPI anchor in ER membrane (GO:0016254)4.20274034
20maturation of SSU-rRNA (GO:0030490)4.08236764
21piRNA metabolic process (GO:0034587)4.05361596
22translational initiation (GO:0006413)3.99892317
23intracellular protein transmembrane import (GO:0044743)3.94275694
24viral life cycle (GO:0019058)3.93961944
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85046382
26cellular protein complex disassembly (GO:0043624)3.76045293
27translation (GO:0006412)3.75413420
28inner mitochondrial membrane organization (GO:0007007)3.72155216
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68586442
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68586442
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.68565334
32DNA methylation involved in gamete generation (GO:0043046)3.66965445
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63615750
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.58681152
35male meiosis I (GO:0007141)3.48945055
36protein complex biogenesis (GO:0070271)3.41100141
37positive regulation of interleukin-17 production (GO:0032740)3.35342816
38regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.33020637
39positive regulation of protein homooligomerization (GO:0032464)3.32926247
40protein neddylation (GO:0045116)3.31610265
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.29829696
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.27698760
43NADH dehydrogenase complex assembly (GO:0010257)3.27698760
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27698760
45mitochondrial respiratory chain complex assembly (GO:0033108)3.22221508
46fucose catabolic process (GO:0019317)3.18953253
47L-fucose metabolic process (GO:0042354)3.18953253
48L-fucose catabolic process (GO:0042355)3.18953253
49regulation of isotype switching to IgG isotypes (GO:0048302)3.15566843
50protein targeting to mitochondrion (GO:0006626)3.11488690
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10494988
52protein complex disassembly (GO:0043241)3.06676907
53respiratory chain complex IV assembly (GO:0008535)3.04350496
54activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.03643527
55ribosomal large subunit biogenesis (GO:0042273)3.00874569
56GTP biosynthetic process (GO:0006183)2.99928466
57negative regulation of telomere maintenance (GO:0032205)2.97572256
58establishment of protein localization to mitochondrion (GO:0072655)2.97235141
59intracellular protein transmembrane transport (GO:0065002)2.95041807
60rRNA processing (GO:0006364)2.94235414
61positive regulation of isotype switching (GO:0045830)2.92844636
62protein targeting to membrane (GO:0006612)2.91757224
63cytidine metabolic process (GO:0046087)2.91389603
64cytidine catabolic process (GO:0006216)2.91389603
65cytidine deamination (GO:0009972)2.91389603
66response to xenobiotic stimulus (GO:0009410)2.88630967
67macromolecular complex disassembly (GO:0032984)2.88412493
68rRNA metabolic process (GO:0016072)2.86620770
69cellular component biogenesis (GO:0044085)2.85192642
70positive regulation of defense response to virus by host (GO:0002230)2.84679868
71GPI anchor biosynthetic process (GO:0006506)2.83962657
72electron transport chain (GO:0022900)2.83848157
73ribonucleoprotein complex biogenesis (GO:0022613)2.81074038
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77054206
75respiratory electron transport chain (GO:0022904)2.74614477
76pyrimidine nucleotide catabolic process (GO:0006244)2.74290759
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.73051468
78protein localization to mitochondrion (GO:0070585)2.72337182
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72034392
80GPI anchor metabolic process (GO:0006505)2.71566594
81meiosis I (GO:0007127)2.70877288
82ATP biosynthetic process (GO:0006754)2.69830755
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.69734705
84positive regulation of DNA recombination (GO:0045911)2.69505003
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69075074
86interferon-gamma production (GO:0032609)2.68682542
87base-excision repair, AP site formation (GO:0006285)2.68137535
88tRNA processing (GO:0008033)2.66148079
89regulation of immunoglobulin secretion (GO:0051023)2.62054081
90pseudouridine synthesis (GO:0001522)2.60058789
91rRNA modification (GO:0000154)2.59981979
92positive regulation of cell fate commitment (GO:0010455)2.56701918
93mRNA catabolic process (GO:0006402)2.55805554
94negative regulation of reactive oxygen species metabolic process (GO:2000378)2.55373217
95protein transmembrane transport (GO:0071806)2.54925646
96cytochrome complex assembly (GO:0017004)2.52942591
97positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.52379329
98termination of RNA polymerase I transcription (GO:0006363)2.52294523
99ubiquinone biosynthetic process (GO:0006744)2.49644923
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48772419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.31927176
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06034816
3VDR_22108803_ChIP-Seq_LS180_Human3.41772511
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.41522210
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38173929
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.28797054
7ZNF274_21170338_ChIP-Seq_K562_Hela3.13772782
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.88434193
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86566318
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83366904
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53563732
12VDR_23849224_ChIP-Seq_CD4+_Human2.52956030
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.47607730
14FOXP3_21729870_ChIP-Seq_TREG_Human2.33877955
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.25563371
16ELK1_19687146_ChIP-ChIP_HELA_Human2.24545112
17EZH2_22144423_ChIP-Seq_EOC_Human2.02694092
18YY1_21170310_ChIP-Seq_MESCs_Mouse2.01206804
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99930908
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96901107
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.96622740
22TP53_22573176_ChIP-Seq_HFKS_Human1.93607541
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83036532
24MYC_18940864_ChIP-ChIP_HL60_Human1.77999897
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76283484
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.75700945
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73253893
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68708987
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68613934
30IRF1_19129219_ChIP-ChIP_H3396_Human1.66904692
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62319781
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.60672569
33EWS_26573619_Chip-Seq_HEK293_Human1.55070420
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53742437
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51173239
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46924074
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46468203
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44339394
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42327894
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41511796
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37483591
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36882447
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36559199
44NANOG_20526341_ChIP-Seq_ESCs_Human1.33453419
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32692522
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.27328559
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24390780
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24371027
49* TTF2_22483619_ChIP-Seq_HELA_Human1.22519444
50GABP_19822575_ChIP-Seq_HepG2_Human1.20732473
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20730788
52SOX2_19829295_ChIP-Seq_ESCs_Human1.19469131
53NANOG_19829295_ChIP-Seq_ESCs_Human1.19469131
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17867841
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.17306573
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14226072
57XRN2_22483619_ChIP-Seq_HELA_Human1.13270085
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11740492
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11669536
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.10571612
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10504161
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.09460407
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09460407
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08368065
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08010758
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07782200
67AR_20517297_ChIP-Seq_VCAP_Human1.06743004
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04898493
69HOXB7_26014856_ChIP-Seq_BT474_Human1.04794997
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04768614
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04485205
72GATA3_26560356_Chip-Seq_TH2_Human1.03619805
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03352596
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01388999
75RNF2_27304074_Chip-Seq_NSC_Mouse1.01067604
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01049625
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00961335
78MYC_19829295_ChIP-Seq_ESCs_Human1.00518249
79GATA3_21867929_ChIP-Seq_TH1_Mouse1.00028555
80TAF2_19829295_ChIP-Seq_ESCs_Human0.99369656
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98831426
82REST_21632747_ChIP-Seq_MESCs_Mouse0.98526247
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98257979
84STAT1_20625510_ChIP-Seq_HELA_Human0.97603789
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97185042
86CIITA_25753668_ChIP-Seq_RAJI_Human0.96678647
87CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95326312
88P300_19829295_ChIP-Seq_ESCs_Human0.94964219
89IGF1R_20145208_ChIP-Seq_DFB_Human0.94581451
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93712906
91ERA_21632823_ChIP-Seq_H3396_Human0.92813508
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90827143
93E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89664776
94TAF15_26573619_Chip-Seq_HEK293_Human0.87397699
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.87293024
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86264441
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.86155846
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86069109
99NCOR_22424771_ChIP-Seq_293T_Human0.85701864
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84878655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.95849924
2MP0009379_abnormal_foot_pigmentation3.86301780
3MP0003646_muscle_fatigue3.56855764
4MP0005670_abnormal_white_adipose2.75857422
5MP0008789_abnormal_olfactory_epithelium2.46929883
6MP0008877_abnormal_DNA_methylation2.45119611
7MP0001968_abnormal_touch/_nociception2.40760006
8MP0005671_abnormal_response_to2.36578856
9MP0002163_abnormal_gland_morphology2.34959966
10MP0002102_abnormal_ear_morphology2.29000397
11MP0003011_delayed_dark_adaptation2.12314923
12MP0001348_abnormal_lacrimal_gland2.04976365
13MP0002736_abnormal_nociception_after2.02502851
14MP0003806_abnormal_nucleotide_metabolis1.96680137
15MP0002138_abnormal_hepatobiliary_system1.89779730
16MP0001986_abnormal_taste_sensitivity1.88004650
17MP0001835_abnormal_antigen_presentation1.84815120
18MP0005394_taste/olfaction_phenotype1.82611002
19MP0005499_abnormal_olfactory_system1.82611002
20MP0003787_abnormal_imprinting1.78605807
21MP0003786_premature_aging1.77015856
22MP0004742_abnormal_vestibular_system1.73210877
23MP0008872_abnormal_physiological_respon1.70852109
24MP0003878_abnormal_ear_physiology1.69809802
25MP0005377_hearing/vestibular/ear_phenot1.69809802
26MP0002837_dystrophic_cardiac_calcinosis1.62974958
27MP0000685_abnormal_immune_system1.61031075
28MP0000015_abnormal_ear_pigmentation1.60319721
29MP0001790_abnormal_immune_system1.60069388
30MP0005387_immune_system_phenotype1.60069388
31MP0006072_abnormal_retinal_apoptosis1.59985714
32MP0005084_abnormal_gallbladder_morpholo1.59763598
33MP0005379_endocrine/exocrine_gland_phen1.53899546
34MP0001485_abnormal_pinna_reflex1.51079239
35MP0004142_abnormal_muscle_tone1.49023752
36MP0000372_irregular_coat_pigmentation1.47040704
37MP0005551_abnormal_eye_electrophysiolog1.44345927
38MP0005174_abnormal_tail_pigmentation1.42779809
39MP0006036_abnormal_mitochondrial_physio1.42525672
40MP0004145_abnormal_muscle_electrophysio1.41495433
41MP0005645_abnormal_hypothalamus_physiol1.38329431
42MP0002272_abnormal_nervous_system1.37420043
43MP0001293_anophthalmia1.31197039
44MP0009333_abnormal_splenocyte_physiolog1.31126949
45MP0002876_abnormal_thyroid_physiology1.29794945
46MP0003136_yellow_coat_color1.24852787
47MP0001919_abnormal_reproductive_system1.23929709
48MP0008057_abnormal_DNA_replication1.23813713
49MP0001800_abnormal_humoral_immune1.23328790
50MP0003567_abnormal_fetal_cardiomyocyte1.23267228
51MP0001984_abnormal_olfaction1.22414295
52MP0009745_abnormal_behavioral_response1.20853677
53MP0004885_abnormal_endolymph1.17917404
54MP0005389_reproductive_system_phenotype1.16411757
55MP0001501_abnormal_sleep_pattern1.16010318
56MP0002095_abnormal_skin_pigmentation1.15717086
57MP0008875_abnormal_xenobiotic_pharmacok1.14375182
58MP0005167_abnormal_blood-brain_barrier1.12787165
59MP0003763_abnormal_thymus_physiology1.12641933
60MP0000631_abnormal_neuroendocrine_gland1.10255073
61MP0006035_abnormal_mitochondrial_morpho1.09536951
62MP0010030_abnormal_orbit_morphology1.02571981
63MP0005408_hypopigmentation1.01995863
64MP0002723_abnormal_immune_serum1.01225723
65MP0005253_abnormal_eye_physiology1.00784518
66MP0003959_abnormal_lean_body0.98784966
67MP0002148_abnormal_hypersensitivity_rea0.96773915
68MP0002160_abnormal_reproductive_system0.96673579
69MP0001905_abnormal_dopamine_level0.96149567
70MP0002938_white_spotting0.94668287
71MP0001440_abnormal_grooming_behavior0.93487933
72MP0001502_abnormal_circadian_rhythm0.91892998
73MP0002735_abnormal_chemical_nociception0.91391746
74MP0003121_genomic_imprinting0.91342458
75MP0008058_abnormal_DNA_repair0.90196827
76MP0000427_abnormal_hair_cycle0.89848346
77MP0002210_abnormal_sex_determination0.89228693
78MP0001853_heart_inflammation0.88421091
79MP0001529_abnormal_vocalization0.82893192
80MP0001663_abnormal_digestive_system0.81068331
81MP0003252_abnormal_bile_duct0.80990713
82MP0009046_muscle_twitch0.80706247
83MP0002006_tumorigenesis0.79755278
84MP0001486_abnormal_startle_reflex0.79377134
85MP0003122_maternal_imprinting0.79345949
86MP0003880_abnormal_central_pattern0.79122219
87MP0004036_abnormal_muscle_relaxation0.78329552
88MP0000049_abnormal_middle_ear0.77390566
89MP0003938_abnormal_ear_development0.76239371
90MP0005083_abnormal_biliary_tract0.75781212
91MP0001873_stomach_inflammation0.74187644
92MP0003879_abnormal_hair_cell0.72806108
93MP0003718_maternal_effect0.72485268
94MP0003186_abnormal_redox_activity0.71737154
95MP0005075_abnormal_melanosome_morpholog0.71590883
96MP0006276_abnormal_autonomic_nervous0.70565443
97MP0004133_heterotaxia0.70250018
98MP0003866_abnormal_defecation0.69852501
99MP0002452_abnormal_antigen_presenting0.69739093
100MP0005000_abnormal_immune_tolerance0.69032451

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.72539005
2Colon cancer (HP:0003003)3.54528343
3Panhypogammaglobulinemia (HP:0003139)3.47575920
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.46018149
5Pancreatic cysts (HP:0001737)3.30145163
6Methylmalonic aciduria (HP:0012120)3.30075014
7Stomatitis (HP:0010280)3.25366387
8Increased hepatocellular lipid droplets (HP:0006565)3.13525624
9Mitochondrial inheritance (HP:0001427)3.12892091
10Elevated erythrocyte sedimentation rate (HP:0003565)3.09843892
11Acute necrotizing encephalopathy (HP:0006965)3.07130283
12Abnormality of cells of the erythroid lineage (HP:0012130)3.06656859
13Reticulocytopenia (HP:0001896)3.05517761
14Methylmalonic acidemia (HP:0002912)3.03502401
15IgG deficiency (HP:0004315)2.93371382
16Increased muscle lipid content (HP:0009058)2.92588484
17Increased CSF lactate (HP:0002490)2.92090034
18Abnormal biliary tract physiology (HP:0012439)2.86661809
19Bile duct proliferation (HP:0001408)2.86661809
20Renal Fanconi syndrome (HP:0001994)2.82054858
21Absent thumb (HP:0009777)2.80883822
22Progressive macrocephaly (HP:0004481)2.78908416
23Abnormal drinking behavior (HP:0030082)2.77934238
24Polydipsia (HP:0001959)2.77934238
25Acute encephalopathy (HP:0006846)2.76964002
26Increased IgM level (HP:0003496)2.76124098
27Abnormal number of erythroid precursors (HP:0012131)2.71662263
28Pancreatic fibrosis (HP:0100732)2.71020363
29Abnormal mitochondria in muscle tissue (HP:0008316)2.68560847
30Molar tooth sign on MRI (HP:0002419)2.68393967
31Abnormality of midbrain morphology (HP:0002418)2.68393967
32Hepatocellular necrosis (HP:0001404)2.66072401
33Congenital stationary night blindness (HP:0007642)2.59498371
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.57094427
35Enlarged kidneys (HP:0000105)2.56813122
36Congenital, generalized hypertrichosis (HP:0004540)2.52344577
37Adrenal hypoplasia (HP:0000835)2.50643904
38Asplenia (HP:0001746)2.48283527
39Abolished electroretinogram (ERG) (HP:0000550)2.43025494
40Hyperglycinemia (HP:0002154)2.41641167
41Macrocytic anemia (HP:0001972)2.40886918
42Type II lissencephaly (HP:0007260)2.35708500
43True hermaphroditism (HP:0010459)2.34994044
44Nephronophthisis (HP:0000090)2.33947249
45Respiratory difficulties (HP:0002880)2.33470764
46Agammaglobulinemia (HP:0004432)2.33432495
47Pendular nystagmus (HP:0012043)2.32314105
48Supernumerary spleens (HP:0009799)2.31725090
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30271867
50Dicarboxylic aciduria (HP:0003215)2.30271867
513-Methylglutaconic aciduria (HP:0003535)2.29062000
52Hepatic necrosis (HP:0002605)2.26962289
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26580112
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26542948
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26542948
56Chronic mucocutaneous candidiasis (HP:0002728)2.25697322
57Recurrent cutaneous fungal infections (HP:0011370)2.25697322
58Optic disc pallor (HP:0000543)2.23677452
59Abnormality of T cell physiology (HP:0011840)2.23212609
60Abnormal rod and cone electroretinograms (HP:0008323)2.22636150
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22088103
62Hip dysplasia (HP:0001385)2.21136559
63Increased serum lactate (HP:0002151)2.18312230
64Polyuria (HP:0000103)2.16245235
65Respiratory failure (HP:0002878)2.09652222
66Abnormality of the labia minora (HP:0012880)2.08175623
67Lethargy (HP:0001254)2.07522159
68Exertional dyspnea (HP:0002875)2.07492735
69Lactic acidosis (HP:0003128)2.06394556
70Pallor (HP:0000980)2.05442657
71Rib fusion (HP:0000902)2.05332840
72Sclerocornea (HP:0000647)2.04386594
73Septo-optic dysplasia (HP:0100842)2.00376533
74Abnormal ciliary motility (HP:0012262)1.99560868
75Abnormality of the renal medulla (HP:0100957)1.97219107
76Increased intramyocellular lipid droplets (HP:0012240)1.93953359
77Mutism (HP:0002300)1.91689486
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91537856
79Progressive inability to walk (HP:0002505)1.90286898
80Chorioretinal atrophy (HP:0000533)1.90087781
81Abnormality of urine glucose concentration (HP:0011016)1.88818378
82Glycosuria (HP:0003076)1.88818378
83Concave nail (HP:0001598)1.88051333
84Chronic hepatic failure (HP:0100626)1.87922406
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.87769641
86Cerebral edema (HP:0002181)1.87308767
87Neutropenia (HP:0001875)1.86578020
88Cerebral hypomyelination (HP:0006808)1.82775868
89Nephrogenic diabetes insipidus (HP:0009806)1.82657342
90Hypoplasia of the radius (HP:0002984)1.82179122
91Abnormality of the renal cortex (HP:0011035)1.80945792
92Tubular atrophy (HP:0000092)1.80819636
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.80156905
94Cystic liver disease (HP:0006706)1.79567042
95Abnormality of glycine metabolism (HP:0010895)1.79068854
96Abnormality of serine family amino acid metabolism (HP:0010894)1.79068854
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78347978
98Medial flaring of the eyebrow (HP:0010747)1.77933720
99Abnormality of renal resorption (HP:0011038)1.74880665
100Abnormality of vitamin B metabolism (HP:0004340)1.73781025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.63858568
2ADRBK23.42144707
3FRK3.27379878
4ERN13.22728890
5WNK42.82156249
6TLK12.59142746
7DYRK22.36761137
8VRK22.32362487
9NEK12.09942482
10ZAK2.01003526
11BCKDK1.95787805
12PINK11.80664078
13STK391.76339817
14TSSK61.68365058
15MST41.67508410
16GRK11.65930421
17CSNK1G31.65039435
18CDK191.62430020
19CSNK1A1L1.58735655
20MAP2K21.57177457
21CSNK1G21.47010829
22CAMKK21.43646537
23IKBKE1.43153390
24CSNK1G11.42151443
25VRK11.40684970
26TEC1.37297064
27EIF2AK31.36201375
28SRPK11.29092098
29ADRBK11.23851471
30NUAK11.18094123
31BMPR1B1.16802826
32OXSR11.14516233
33NLK1.08654192
34PLK31.08033545
35IKBKB1.07034502
36ITK1.00729483
37FGFR20.99961230
38FES0.99165222
39TRIM280.98470649
40MAP4K20.97131087
41STK160.96123541
42PAK30.95287684
43RPS6KA50.94464668
44EIF2AK10.94318405
45IRAK20.93498081
46MKNK20.92530226
47MAP4K10.91115953
48DAPK20.84510072
49BUB10.80325260
50PDK20.80007395
51STK110.78608079
52TAF10.77957900
53PRKCG0.75893880
54PASK0.75245611
55ACVR1B0.73512496
56LRRK20.72602477
57INSRR0.71264782
58TYRO30.70525656
59PHKG20.68538847
60PHKG10.68538847
61MAP2K60.66892510
62CSNK2A20.66781681
63BTK0.62177326
64MKNK10.61725833
65CSNK1A10.60399239
66STK240.59998243
67PLK10.57467561
68MUSK0.57297316
69MARK30.57164424
70PRKCQ0.56635406
71DAPK30.54190336
72PIK3CA0.50524728
73TNIK0.49235986
74WNK10.48081394
75LYN0.47597415
76MAP3K80.47033942
77CSNK2A10.45547727
78MAPK130.45387517
79TGFBR10.45033117
80MAP2K10.45024588
81TAOK30.44605946
82GRK70.44000861
83JAK30.43172900
84DYRK1A0.43061692
85PRKCZ0.42862121
86PRKCI0.42721902
87SYK0.41406979
88CAMKK10.41150198
89PRKACA0.40606629
90CSNK1E0.40347319
91TIE10.40187595
92PRKCE0.40062386
93MAPKAPK50.39975437
94WEE10.39794667
95BRSK20.39770926
96IGF1R0.39167244
97PRKCD0.38783887
98EIF2AK20.38692944
99PLK20.38685291
100RPS6KA60.37972658

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.81593262
2Asthma_Homo sapiens_hsa053103.22205637
3Allograft rejection_Homo sapiens_hsa053303.02465300
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.93824089
5Oxidative phosphorylation_Homo sapiens_hsa001902.90465164
6Autoimmune thyroid disease_Homo sapiens_hsa053202.90110811
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67206632
8Parkinsons disease_Homo sapiens_hsa050122.62005717
9Graft-versus-host disease_Homo sapiens_hsa053322.49997854
10Proteasome_Homo sapiens_hsa030502.42542419
11Protein export_Homo sapiens_hsa030602.29704469
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20578575
13Type I diabetes mellitus_Homo sapiens_hsa049402.20500015
14Primary immunodeficiency_Homo sapiens_hsa053402.20487292
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91507979
16Homologous recombination_Homo sapiens_hsa034401.85759266
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83448872
18RNA polymerase_Homo sapiens_hsa030201.78822354
19Huntingtons disease_Homo sapiens_hsa050161.77397055
20Alzheimers disease_Homo sapiens_hsa050101.68778418
21Basal transcription factors_Homo sapiens_hsa030221.67296215
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60320664
23Linoleic acid metabolism_Homo sapiens_hsa005911.53047925
24Antigen processing and presentation_Homo sapiens_hsa046121.46646598
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40255658
26Propanoate metabolism_Homo sapiens_hsa006401.36214184
27Sulfur relay system_Homo sapiens_hsa041221.34811400
28Cardiac muscle contraction_Homo sapiens_hsa042601.34797741
29RNA degradation_Homo sapiens_hsa030181.29169729
30Phototransduction_Homo sapiens_hsa047441.26083369
31One carbon pool by folate_Homo sapiens_hsa006701.23989122
32Fanconi anemia pathway_Homo sapiens_hsa034601.21479988
33Viral myocarditis_Homo sapiens_hsa054161.19472468
34Vitamin B6 metabolism_Homo sapiens_hsa007501.10819719
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09357052
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06960189
37Rheumatoid arthritis_Homo sapiens_hsa053231.05152040
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03142636
39RNA transport_Homo sapiens_hsa030131.00813689
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00485028
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99029447
42Pyrimidine metabolism_Homo sapiens_hsa002400.95179505
43Systemic lupus erythematosus_Homo sapiens_hsa053220.95126710
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94951621
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91083261
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90435571
47Nucleotide excision repair_Homo sapiens_hsa034200.88850890
48Base excision repair_Homo sapiens_hsa034100.88084654
49Non-homologous end-joining_Homo sapiens_hsa034500.88043766
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87528269
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87353702
52Arachidonic acid metabolism_Homo sapiens_hsa005900.86331950
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81346516
54Mismatch repair_Homo sapiens_hsa034300.80245729
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.76794501
56Hematopoietic cell lineage_Homo sapiens_hsa046400.73911397
57Nitrogen metabolism_Homo sapiens_hsa009100.72942206
58Ether lipid metabolism_Homo sapiens_hsa005650.72812425
59Olfactory transduction_Homo sapiens_hsa047400.67731441
60Caffeine metabolism_Homo sapiens_hsa002320.66096199
61Peroxisome_Homo sapiens_hsa041460.63898156
62Steroid biosynthesis_Homo sapiens_hsa001000.62436213
63Tryptophan metabolism_Homo sapiens_hsa003800.61904539
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59340992
65Purine metabolism_Homo sapiens_hsa002300.58414431
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.57245499
67p53 signaling pathway_Homo sapiens_hsa041150.56081815
68Spliceosome_Homo sapiens_hsa030400.55003752
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.54977840
70Metabolic pathways_Homo sapiens_hsa011000.54950064
71Nicotine addiction_Homo sapiens_hsa050330.53739718
72Sulfur metabolism_Homo sapiens_hsa009200.51585216
73Selenocompound metabolism_Homo sapiens_hsa004500.49417663
74DNA replication_Homo sapiens_hsa030300.47980005
75Collecting duct acid secretion_Homo sapiens_hsa049660.47374071
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45922328
77Pyruvate metabolism_Homo sapiens_hsa006200.40538087
78T cell receptor signaling pathway_Homo sapiens_hsa046600.39821312
79Butanoate metabolism_Homo sapiens_hsa006500.39453313
80Fat digestion and absorption_Homo sapiens_hsa049750.38927435
81Serotonergic synapse_Homo sapiens_hsa047260.38450681
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.37862353
83Retinol metabolism_Homo sapiens_hsa008300.37704698
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36616624
85Arginine and proline metabolism_Homo sapiens_hsa003300.34950935
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.32891478
87Dorso-ventral axis formation_Homo sapiens_hsa043200.32820229
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.32457133
89Ovarian steroidogenesis_Homo sapiens_hsa049130.30591436
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30346340
91Chemical carcinogenesis_Homo sapiens_hsa052040.29846123
92Fatty acid metabolism_Homo sapiens_hsa012120.29120652
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27837802
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.27017563
95Folate biosynthesis_Homo sapiens_hsa007900.26818401
96Staphylococcus aureus infection_Homo sapiens_hsa051500.23229652
97Measles_Homo sapiens_hsa051620.22680143
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22435376
99GABAergic synapse_Homo sapiens_hsa047270.21357307
100Vitamin digestion and absorption_Homo sapiens_hsa049770.21242759

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