RPL23AP53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.76060069
2response to pheromone (GO:0019236)4.26792178
3negative regulation of mast cell activation (GO:0033004)4.10633653
4protein complex biogenesis (GO:0070271)4.09144981
5platelet dense granule organization (GO:0060155)3.91066793
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88433716
7cytidine deamination (GO:0009972)3.81251504
8cytidine metabolic process (GO:0046087)3.81251504
9cytidine catabolic process (GO:0006216)3.81251504
10mitochondrial respiratory chain complex assembly (GO:0033108)3.76193765
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72504198
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.72504198
13NADH dehydrogenase complex assembly (GO:0010257)3.72504198
14behavioral response to nicotine (GO:0035095)3.68783832
15water-soluble vitamin biosynthetic process (GO:0042364)3.59351874
16piRNA metabolic process (GO:0034587)3.55525346
17respiratory chain complex IV assembly (GO:0008535)3.54509859
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53394107
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53394107
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36043200
21ubiquinone biosynthetic process (GO:0006744)3.32914817
22cytochrome complex assembly (GO:0017004)3.27553190
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.23547077
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23282757
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.21742452
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17245253
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.16748882
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15163818
29ATP synthesis coupled proton transport (GO:0015986)3.15163818
30L-fucose catabolic process (GO:0042355)3.14513598
31fucose catabolic process (GO:0019317)3.14513598
32L-fucose metabolic process (GO:0042354)3.14513598
33protein-cofactor linkage (GO:0018065)3.13591496
34indolalkylamine metabolic process (GO:0006586)3.05683036
35amino acid salvage (GO:0043102)3.04947721
36L-methionine salvage (GO:0071267)3.04947721
37L-methionine biosynthetic process (GO:0071265)3.04947721
38detection of light stimulus involved in sensory perception (GO:0050962)2.99292716
39detection of light stimulus involved in visual perception (GO:0050908)2.99292716
40signal peptide processing (GO:0006465)2.99112452
41regulation of action potential (GO:0098900)2.97988546
42positive regulation of mitochondrial fission (GO:0090141)2.95686684
43ubiquinone metabolic process (GO:0006743)2.95287384
44negative regulation of telomere maintenance (GO:0032205)2.93456995
45tryptophan catabolic process (GO:0006569)2.92752418
46indole-containing compound catabolic process (GO:0042436)2.92752418
47indolalkylamine catabolic process (GO:0046218)2.92752418
48protein localization to cilium (GO:0061512)2.90639034
49regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.89965210
50male meiosis (GO:0007140)2.88258021
51axoneme assembly (GO:0035082)2.85886887
52methionine biosynthetic process (GO:0009086)2.83172427
53positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82642413
54multicellular organism reproduction (GO:0032504)2.82345225
55retinal cone cell development (GO:0046549)2.82328816
56regulation of glucokinase activity (GO:0033131)2.81897682
57regulation of hexokinase activity (GO:1903299)2.81897682
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79815744
59positive regulation of defense response to virus by host (GO:0002230)2.78950213
60sequestering of actin monomers (GO:0042989)2.75083540
61DNA methylation involved in gamete generation (GO:0043046)2.71111491
62termination of RNA polymerase III transcription (GO:0006386)2.70597133
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.70597133
64electron transport chain (GO:0022900)2.68915551
65preassembly of GPI anchor in ER membrane (GO:0016254)2.68688385
66quinone biosynthetic process (GO:1901663)2.65811096
67mannosylation (GO:0097502)2.65508349
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64392634
69proteasome assembly (GO:0043248)2.63423704
70sulfation (GO:0051923)2.61945405
71respiratory electron transport chain (GO:0022904)2.61701183
72adaptation of signaling pathway (GO:0023058)2.60840284
73peptidyl-histidine modification (GO:0018202)2.58602592
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57302113
75negative regulation of nitric-oxide synthase activity (GO:0051001)2.54589428
76synapsis (GO:0007129)2.53479815
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51750360
78positive regulation of prostaglandin secretion (GO:0032308)2.50773191
79cellular ketone body metabolic process (GO:0046950)2.49918779
80DNA demethylation (GO:0080111)2.47866380
81protein neddylation (GO:0045116)2.46764160
82proton transport (GO:0015992)2.46507887
83rhodopsin mediated signaling pathway (GO:0016056)2.44975658
84GPI anchor metabolic process (GO:0006505)2.44898486
85S-adenosylmethionine metabolic process (GO:0046500)2.44270386
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.44101117
87methionine metabolic process (GO:0006555)2.42799514
88tRNA processing (GO:0008033)2.42756084
89hydrogen transport (GO:0006818)2.41772164
90negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.40963873
91rRNA catabolic process (GO:0016075)2.40880803
92base-excision repair, AP site formation (GO:0006285)2.38619569
93kidney morphogenesis (GO:0060993)2.38383145
94negative regulation of heart rate (GO:0010459)2.38092799
95kynurenine metabolic process (GO:0070189)2.37452257
96iron-sulfur cluster assembly (GO:0016226)2.37213158
97metallo-sulfur cluster assembly (GO:0031163)2.37213158
98regulation of regulatory T cell differentiation (GO:0045589)2.37136559
99DNA double-strand break processing (GO:0000729)2.37043681
100hydrogen ion transmembrane transport (GO:1902600)2.36274623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.86936999
2ZNF274_21170338_ChIP-Seq_K562_Hela4.09687370
3VDR_22108803_ChIP-Seq_LS180_Human3.47438949
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.19998831
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07705862
6IGF1R_20145208_ChIP-Seq_DFB_Human2.92649406
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.85472820
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52104339
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42984637
10EZH2_22144423_ChIP-Seq_EOC_Human2.31074971
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.29658713
12GBX2_23144817_ChIP-Seq_PC3_Human2.26188443
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19918689
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.18840916
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99619309
16VDR_23849224_ChIP-Seq_CD4+_Human1.99080275
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90347742
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87031782
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85973479
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83944441
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.79257216
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71299249
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70072830
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.68745018
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67340681
26TP53_22573176_ChIP-Seq_HFKS_Human1.66940726
27ER_23166858_ChIP-Seq_MCF-7_Human1.65949123
28EWS_26573619_Chip-Seq_HEK293_Human1.64352545
29P300_19829295_ChIP-Seq_ESCs_Human1.58839223
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.56732211
31CBP_20019798_ChIP-Seq_JUKART_Human1.54101179
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54101179
33MYC_18940864_ChIP-ChIP_HL60_Human1.53967934
34TAF15_26573619_Chip-Seq_HEK293_Human1.53706260
35FUS_26573619_Chip-Seq_HEK293_Human1.52619663
36ELK1_19687146_ChIP-ChIP_HELA_Human1.49324614
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.47648721
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46262866
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44468828
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42712031
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38850202
42BCAT_22108803_ChIP-Seq_LS180_Human1.36792600
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.36699821
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36699821
45NCOR_22424771_ChIP-Seq_293T_Human1.36273891
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34828019
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34347243
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31574066
49FOXP3_21729870_ChIP-Seq_TREG_Human1.29713118
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28864233
51IRF1_19129219_ChIP-ChIP_H3396_Human1.28346592
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27870539
53AR_20517297_ChIP-Seq_VCAP_Human1.27376157
54SOX2_19829295_ChIP-Seq_ESCs_Human1.26454205
55NANOG_19829295_ChIP-Seq_ESCs_Human1.26454205
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20767415
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20071799
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19547627
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.18419334
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18089246
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17754396
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17725992
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16598356
64GATA3_26560356_Chip-Seq_TH2_Human1.16332705
65NANOG_20526341_ChIP-Seq_ESCs_Human1.16008750
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15685043
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15346414
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13677935
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.12384375
70AR_25329375_ChIP-Seq_VCAP_Human1.12368825
71HTT_18923047_ChIP-ChIP_STHdh_Human1.08147939
72MYC_19829295_ChIP-Seq_ESCs_Human1.06828053
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06223826
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.03703315
75ERA_21632823_ChIP-Seq_H3396_Human1.03037682
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.02833095
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02487542
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02463061
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.02462004
80RNF2_27304074_Chip-Seq_NSC_Mouse1.01834698
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00242462
82HOXB7_26014856_ChIP-Seq_BT474_Human0.98279253
83TCF4_22108803_ChIP-Seq_LS180_Human0.97975659
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97849754
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96806289
86TAF2_19829295_ChIP-Seq_ESCs_Human0.93198547
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92796576
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.92008951
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90947019
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90700112
91SMAD4_21799915_ChIP-Seq_A2780_Human0.90025237
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89930791
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89490377
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.88557026
95STAT3_23295773_ChIP-Seq_U87_Human0.88417657
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87090059
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86046937
98PHF8_20622853_ChIP-Seq_HELA_Human0.85835046
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.84741323
100TCF4_23295773_ChIP-Seq_U87_Human0.84450959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.87250625
2MP0002837_dystrophic_cardiac_calcinosis3.87195293
3MP0008877_abnormal_DNA_methylation3.12943035
4MP0005646_abnormal_pituitary_gland2.55092276
5MP0005645_abnormal_hypothalamus_physiol2.54966062
6MP0003646_muscle_fatigue2.49350480
7MP0006072_abnormal_retinal_apoptosis2.26886088
8MP0000372_irregular_coat_pigmentation2.24619828
9MP0005671_abnormal_response_to2.14320465
10MP0003195_calcinosis2.06972707
11MP0002876_abnormal_thyroid_physiology2.03643035
12MP0003806_abnormal_nucleotide_metabolis1.98178711
13MP0002160_abnormal_reproductive_system1.85586519
14MP0002736_abnormal_nociception_after1.79475436
15MP0001968_abnormal_touch/_nociception1.79403906
16MP0005551_abnormal_eye_electrophysiolog1.77861552
17MP0001984_abnormal_olfaction1.75679774
18MP0006276_abnormal_autonomic_nervous1.70211713
19MP0008872_abnormal_physiological_respon1.70069536
20MP0008875_abnormal_xenobiotic_pharmacok1.68156462
21MP0005389_reproductive_system_phenotype1.64929525
22MP0005410_abnormal_fertilization1.64672588
23MP0002163_abnormal_gland_morphology1.64166286
24MP0005253_abnormal_eye_physiology1.64003160
25MP0009046_muscle_twitch1.63513413
26MP0003011_delayed_dark_adaptation1.62976052
27MP0004885_abnormal_endolymph1.56431626
28MP0003283_abnormal_digestive_organ1.53695865
29MP0001529_abnormal_vocalization1.51697394
30MP0001905_abnormal_dopamine_level1.50923886
31MP0004145_abnormal_muscle_electrophysio1.48824190
32MP0002653_abnormal_ependyma_morphology1.47884457
33MP0005379_endocrine/exocrine_gland_phen1.47335947
34MP0004142_abnormal_muscle_tone1.45882989
35MP0002272_abnormal_nervous_system1.44361595
36MP0001919_abnormal_reproductive_system1.43211747
37MP0003718_maternal_effect1.38085815
38MP0002735_abnormal_chemical_nociception1.36853749
39MP0003880_abnormal_central_pattern1.33323185
40MP0006036_abnormal_mitochondrial_physio1.32727632
41MP0009745_abnormal_behavioral_response1.31136838
42MP0008789_abnormal_olfactory_epithelium1.25651953
43MP0008995_early_reproductive_senescence1.25074632
44MP0001501_abnormal_sleep_pattern1.22619630
45MP0010386_abnormal_urinary_bladder1.22099084
46MP0000631_abnormal_neuroendocrine_gland1.18467377
47MP0005075_abnormal_melanosome_morpholog1.17604357
48MP0001764_abnormal_homeostasis1.15375675
49MP0001986_abnormal_taste_sensitivity1.13831077
50MP0009785_altered_susceptibility_to1.10734949
51MP0009697_abnormal_copulation1.07363181
52MP0008058_abnormal_DNA_repair1.07290307
53MP0002693_abnormal_pancreas_physiology1.06892192
54MP0004742_abnormal_vestibular_system1.05823891
55MP0001929_abnormal_gametogenesis1.05656404
56MP0006292_abnormal_olfactory_placode1.03243739
57MP0002733_abnormal_thermal_nociception1.01538295
58MP0008775_abnormal_heart_ventricle1.00699743
59MP0002638_abnormal_pupillary_reflex0.98577446
60MP0003787_abnormal_imprinting0.98172605
61MP0004147_increased_porphyrin_level0.96625075
62MP0005084_abnormal_gallbladder_morpholo0.95710442
63MP0002210_abnormal_sex_determination0.95224548
64MP0002138_abnormal_hepatobiliary_system0.95215521
65MP0003950_abnormal_plasma_membrane0.95029246
66MP0001485_abnormal_pinna_reflex0.94972663
67MP0000427_abnormal_hair_cycle0.93997315
68MP0003698_abnormal_male_reproductive0.93605631
69MP0001502_abnormal_circadian_rhythm0.93444958
70MP0005394_taste/olfaction_phenotype0.92968203
71MP0005499_abnormal_olfactory_system0.92968203
72MP0004924_abnormal_behavior0.92693631
73MP0005386_behavior/neurological_phenoty0.92693631
74MP0000749_muscle_degeneration0.92455638
75MP0001970_abnormal_pain_threshold0.91895261
76MP0006035_abnormal_mitochondrial_morpho0.90900058
77MP0004215_abnormal_myocardial_fiber0.88092005
78MP0004084_abnormal_cardiac_muscle0.87690824
79MP0003763_abnormal_thymus_physiology0.87088102
80MP0002277_abnormal_respiratory_mucosa0.87052701
81MP0005266_abnormal_metabolism0.86778001
82MP0002148_abnormal_hypersensitivity_rea0.86600066
83MP0000230_abnormal_systemic_arterial0.86130585
84MP0003186_abnormal_redox_activity0.83474811
85MP0002095_abnormal_skin_pigmentation0.82419231
86MP0005187_abnormal_penis_morphology0.82245378
87MP0009840_abnormal_foam_cell0.81986766
88MP0002064_seizures0.81877530
89MP0005636_abnormal_mineral_homeostasis0.79196293
90MP0000653_abnormal_sex_gland0.77125561
91MP0001119_abnormal_female_reproductive0.76829648
92MP0002557_abnormal_social/conspecific_i0.76641755
93MP0001835_abnormal_antigen_presentation0.75930095
94MP0002572_abnormal_emotion/affect_behav0.74951896
95MP0003137_abnormal_impulse_conducting0.73027399
96MP0001486_abnormal_startle_reflex0.71353058
97MP0005332_abnormal_amino_acid0.71077902
98MP0001873_stomach_inflammation0.70715552
99MP0005174_abnormal_tail_pigmentation0.70238270
100MP0001145_abnormal_male_reproductive0.69598496

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.72765255
2Type II lissencephaly (HP:0007260)3.55837831
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.52547889
4Mitochondrial inheritance (HP:0001427)3.39807328
5Acute necrotizing encephalopathy (HP:0006965)3.35084362
63-Methylglutaconic aciduria (HP:0003535)3.32414753
7Congenital stationary night blindness (HP:0007642)3.24290322
8True hermaphroditism (HP:0010459)3.22823802
9Attenuation of retinal blood vessels (HP:0007843)3.14466474
10Lipid accumulation in hepatocytes (HP:0006561)3.14235415
11Increased CSF lactate (HP:0002490)3.12628548
12Pancreatic fibrosis (HP:0100732)3.08942089
13Abnormal mitochondria in muscle tissue (HP:0008316)3.06586960
14Abnormal rod and cone electroretinograms (HP:0008323)3.04333149
15Methylmalonic acidemia (HP:0002912)3.03061467
16Abnormality of midbrain morphology (HP:0002418)2.96133747
17Molar tooth sign on MRI (HP:0002419)2.96133747
18Progressive macrocephaly (HP:0004481)2.95315515
19Abnormality of alanine metabolism (HP:0010916)2.87720626
20Hyperalaninemia (HP:0003348)2.87720626
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87720626
22Increased hepatocellular lipid droplets (HP:0006565)2.87023544
23Acute encephalopathy (HP:0006846)2.82248484
24Chronic hepatic failure (HP:0100626)2.81112882
25Aplastic anemia (HP:0001915)2.80339903
26Hepatocellular necrosis (HP:0001404)2.76922795
27Abnormality of the renal cortex (HP:0011035)2.75591442
28Methylmalonic aciduria (HP:0012120)2.74665910
29Cerebellar dysplasia (HP:0007033)2.63856120
30Renal cortical cysts (HP:0000803)2.62212374
31Hypothermia (HP:0002045)2.60961476
32Hepatic necrosis (HP:0002605)2.60515523
33Nephronophthisis (HP:0000090)2.54592808
34Decreased central vision (HP:0007663)2.48039424
35IgG deficiency (HP:0004315)2.47801506
36Abolished electroretinogram (ERG) (HP:0000550)2.46856660
37Renal Fanconi syndrome (HP:0001994)2.44037941
38Optic disc pallor (HP:0000543)2.39788837
39Retinal dysplasia (HP:0007973)2.39243172
40Medial flaring of the eyebrow (HP:0010747)2.37365089
41Increased serum lactate (HP:0002151)2.35421779
42Increased intramyocellular lipid droplets (HP:0012240)2.33340354
43Aplasia/hypoplasia of the uterus (HP:0008684)2.30315564
44Pendular nystagmus (HP:0012043)2.29724748
45Calf muscle hypertrophy (HP:0008981)2.23190121
46Abnormality of the renal medulla (HP:0100957)2.23042766
47Muscle hypertrophy of the lower extremities (HP:0008968)2.17078959
48Lactic acidosis (HP:0003128)2.16717625
49Absent/shortened dynein arms (HP:0200106)2.16647758
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.16647758
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16624259
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16624259
53Thyroiditis (HP:0100646)2.14688850
54Increased muscle lipid content (HP:0009058)2.13961692
55Stomatitis (HP:0010280)2.13264231
56Male pseudohermaphroditism (HP:0000037)2.12290496
57Large for gestational age (HP:0001520)2.11572677
58Abnormality of vitamin B metabolism (HP:0004340)2.10800378
59Increased corneal curvature (HP:0100692)2.08743845
60Keratoconus (HP:0000563)2.08743845
61Elevated erythrocyte sedimentation rate (HP:0003565)2.07665919
62Severe combined immunodeficiency (HP:0004430)2.07362013
63Ketosis (HP:0001946)2.06304372
64Inability to walk (HP:0002540)2.02384909
65Abnormality of the vitamin B12 metabolism (HP:0004341)2.02291873
66Cystic liver disease (HP:0006706)2.01010821
67Abnormality of eosinophils (HP:0001879)1.97186254
68Hyperventilation (HP:0002883)1.96679756
69Lissencephaly (HP:0001339)1.92165138
70Abnormal drinking behavior (HP:0030082)1.91384504
71Polydipsia (HP:0001959)1.91384504
72Cerebral edema (HP:0002181)1.90968977
73Hypoplasia of the uterus (HP:0000013)1.90266719
74Absent thumb (HP:0009777)1.88980883
75Abnormality of urine glucose concentration (HP:0011016)1.87756995
76Glycosuria (HP:0003076)1.87756995
77Sclerocornea (HP:0000647)1.87675921
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87385038
79Exertional dyspnea (HP:0002875)1.84776324
80Amyotrophic lateral sclerosis (HP:0007354)1.82962325
81Hypoproteinemia (HP:0003075)1.81294286
82Ketoacidosis (HP:0001993)1.79896638
83Eosinophilia (HP:0001880)1.79670618
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.79502214
85Constricted visual fields (HP:0001133)1.79029150
86Hyperglycinemia (HP:0002154)1.78893347
87Abnormality of the pons (HP:0007361)1.78788095
88Gaze-evoked nystagmus (HP:0000640)1.78013523
89Respiratory failure (HP:0002878)1.76820917
90Short tibia (HP:0005736)1.76469960
91Gait imbalance (HP:0002141)1.76427983
92Abnormality of B cell number (HP:0010975)1.76038445
93Abnormality of serum amino acid levels (HP:0003112)1.74732657
94Intestinal atresia (HP:0011100)1.74438443
95Hypoplasia of the pons (HP:0012110)1.74347533
96Bile duct proliferation (HP:0001408)1.74263785
97Abnormal biliary tract physiology (HP:0012439)1.74263785
98Pachygyria (HP:0001302)1.72555716
99Lethargy (HP:0001254)1.72431374
100Congenital primary aphakia (HP:0007707)1.72401813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.23333818
2MAP4K23.74349983
3FRK3.11089334
4ADRBK23.04686752
5TLK13.03315849
6ZAK2.91514214
7TXK2.84647362
8TAOK32.43311143
9GRK12.26914270
10TRIM282.07059909
11PASK1.82878587
12MAP2K71.75695014
13KDR1.72833012
14BCKDK1.69855134
15NUAK11.67893375
16MAP3K41.65152241
17MAPK131.61932751
18TESK21.57127824
19BMPR1B1.51710899
20CSNK1G31.47938575
21INSRR1.42690265
22CSNK1G21.40733806
23WNK31.40524135
24EIF2AK31.36492103
25MAP3K121.33508117
26OBSCN1.31952838
27MST41.27679830
28CSNK1A1L1.26267351
29MUSK1.25273357
30VRK11.21437845
31CASK1.13055792
32STK38L1.12317559
33CSNK1G11.11627644
34RPS6KA51.08928783
35MAP4K11.05518768
36DYRK21.04978782
37WNK41.01861504
38GRK70.98410415
39MYLK0.98382316
40TEC0.97107512
41PAK30.97008291
42MARK30.96468121
43PIM20.93692051
44LIMK10.91795457
45BCR0.88697198
46PRKCQ0.87975486
47TIE10.86191607
48ITK0.85328419
49ADRBK10.84644545
50CDK80.82305662
51ACVR1B0.81976740
52ERBB30.81044509
53MAPKAPK30.78909757
54TNIK0.78121227
55PHKG20.73969486
56PHKG10.73969486
57CAMKK20.73128065
58GRK60.70110139
59IKBKB0.67674421
60SCYL20.66249416
61DAPK20.65632767
62TNK20.63605537
63SYK0.63602872
64PRKCE0.57626308
65MARK10.56056789
66GRK50.54286915
67PIK3CG0.53511456
68OXSR10.52486461
69MAP2K60.51857186
70FES0.50813285
71SRPK10.50442498
72MAPKAPK50.50006998
73EPHA30.49290371
74PKN10.48714362
75PRKCG0.48692105
76VRK20.46891532
77CAMKK10.45882525
78PRKACA0.45063229
79PIM10.44091112
80BTK0.43266191
81KIT0.43071024
82PRKCI0.43007766
83EIF2AK10.42665091
84TGFBR10.41070292
85PTK2B0.40697960
86CAMK2A0.39987097
87LCK0.39791264
88TRPM70.36729359
89IGF1R0.36009290
90PRKCA0.35515858
91STK160.35481834
92RPS6KA40.35249737
93CSNK2A10.34742803
94ROCK10.34274670
95NME10.33731266
96LYN0.33429686
97PLK20.33049555
98FER0.30711114
99STK390.29402557
100CSNK1D0.29384242

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.37078254
2Protein export_Homo sapiens_hsa030602.72826598
3Phototransduction_Homo sapiens_hsa047442.72023807
4Parkinsons disease_Homo sapiens_hsa050122.69212033
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45836292
6Primary immunodeficiency_Homo sapiens_hsa053402.34915953
7Proteasome_Homo sapiens_hsa030502.32271640
8RNA polymerase_Homo sapiens_hsa030202.28019962
9Nitrogen metabolism_Homo sapiens_hsa009102.22395347
10Basal transcription factors_Homo sapiens_hsa030222.14782185
11Butanoate metabolism_Homo sapiens_hsa006501.88489183
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85698151
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.83755152
14Ribosome_Homo sapiens_hsa030101.82281652
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80248859
16Alzheimers disease_Homo sapiens_hsa050101.70225634
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68140878
18Selenocompound metabolism_Homo sapiens_hsa004501.59997671
19RNA degradation_Homo sapiens_hsa030181.58834227
20Regulation of autophagy_Homo sapiens_hsa041401.56737185
21Huntingtons disease_Homo sapiens_hsa050161.55096062
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53424476
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52889618
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49174194
25Olfactory transduction_Homo sapiens_hsa047401.48207279
26One carbon pool by folate_Homo sapiens_hsa006701.48164519
27Linoleic acid metabolism_Homo sapiens_hsa005911.47839284
28Cardiac muscle contraction_Homo sapiens_hsa042601.47625454
29Collecting duct acid secretion_Homo sapiens_hsa049661.46965311
30Propanoate metabolism_Homo sapiens_hsa006401.33162798
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32557306
32Type I diabetes mellitus_Homo sapiens_hsa049401.30484867
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29542736
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29015938
35Tryptophan metabolism_Homo sapiens_hsa003801.28551626
36Peroxisome_Homo sapiens_hsa041461.26373422
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23038522
38Caffeine metabolism_Homo sapiens_hsa002321.21184730
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20728921
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18986794
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.12934837
42Asthma_Homo sapiens_hsa053101.09607940
43Nicotine addiction_Homo sapiens_hsa050331.08404180
44Graft-versus-host disease_Homo sapiens_hsa053321.08097344
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.07995125
46Homologous recombination_Homo sapiens_hsa034401.07118820
47Fanconi anemia pathway_Homo sapiens_hsa034601.06348238
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05412331
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99232062
50Chemical carcinogenesis_Homo sapiens_hsa052040.97061452
51Taste transduction_Homo sapiens_hsa047420.95850802
52Autoimmune thyroid disease_Homo sapiens_hsa053200.95292494
53Pyrimidine metabolism_Homo sapiens_hsa002400.95203783
54Allograft rejection_Homo sapiens_hsa053300.94721183
55Hematopoietic cell lineage_Homo sapiens_hsa046400.92693037
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92184678
57Purine metabolism_Homo sapiens_hsa002300.92037519
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89880407
59Sulfur metabolism_Homo sapiens_hsa009200.88166590
60Rheumatoid arthritis_Homo sapiens_hsa053230.82503607
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81293275
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80083637
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79156980
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76858008
65Nucleotide excision repair_Homo sapiens_hsa034200.75853533
66Retinol metabolism_Homo sapiens_hsa008300.75309763
67Antigen processing and presentation_Homo sapiens_hsa046120.70976616
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70709592
69ABC transporters_Homo sapiens_hsa020100.69732912
70Metabolic pathways_Homo sapiens_hsa011000.68244243
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67082163
72GABAergic synapse_Homo sapiens_hsa047270.65394497
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64699365
74Ether lipid metabolism_Homo sapiens_hsa005650.63117946
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62379777
76Morphine addiction_Homo sapiens_hsa050320.61216574
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57030297
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56788549
79Circadian entrainment_Homo sapiens_hsa047130.53661729
80Arachidonic acid metabolism_Homo sapiens_hsa005900.52921538
81Base excision repair_Homo sapiens_hsa034100.49907822
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.48309758
83Salivary secretion_Homo sapiens_hsa049700.45281164
84T cell receptor signaling pathway_Homo sapiens_hsa046600.43880469
85Insulin secretion_Homo sapiens_hsa049110.43119251
86beta-Alanine metabolism_Homo sapiens_hsa004100.42963666
87Folate biosynthesis_Homo sapiens_hsa007900.42643179
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42327350
89Mineral absorption_Homo sapiens_hsa049780.42173443
90Systemic lupus erythematosus_Homo sapiens_hsa053220.40120770
91Synaptic vesicle cycle_Homo sapiens_hsa047210.39545978
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39080646
93Serotonergic synapse_Homo sapiens_hsa047260.37200491
94Ovarian steroidogenesis_Homo sapiens_hsa049130.35897269
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35588834
96Calcium signaling pathway_Homo sapiens_hsa040200.32862386
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.30656888
98Sulfur relay system_Homo sapiens_hsa041220.30592239
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29868063
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28646157

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