RPL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational termination (GO:0006415)9.77114361
2ribosomal small subunit biogenesis (GO:0042274)9.20266273
3ribosomal small subunit assembly (GO:0000028)9.03060428
4* translational elongation (GO:0006414)8.28044112
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.06363448
6* protein targeting to ER (GO:0045047)7.90367210
7* cotranslational protein targeting to membrane (GO:0006613)7.89529880
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.66307443
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)7.57354197
10* cellular protein complex disassembly (GO:0043624)7.52201445
11* viral life cycle (GO:0019058)7.51405250
12maturation of SSU-rRNA (GO:0030490)7.45481595
13* protein localization to endoplasmic reticulum (GO:0070972)7.34643466
14* translational initiation (GO:0006413)7.17868046
15ribosomal large subunit biogenesis (GO:0042273)6.85299439
16* protein complex disassembly (GO:0043241)6.62085951
17* macromolecular complex disassembly (GO:0032984)6.15778892
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.41292738
19* protein targeting to membrane (GO:0006612)5.28831373
20* mRNA catabolic process (GO:0006402)5.14068765
21ribonucleoprotein complex biogenesis (GO:0022613)4.98237733
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.93564683
23* RNA catabolic process (GO:0006401)4.82623728
24* translation (GO:0006412)4.75315502
25ATP synthesis coupled proton transport (GO:0015986)4.28824147
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28824147
27formation of translation preinitiation complex (GO:0001731)4.17078310
28rRNA processing (GO:0006364)3.87938892
29rRNA metabolic process (GO:0016072)3.74295805
30ncRNA 3-end processing (GO:0043628)3.69407435
31regulation of translational fidelity (GO:0006450)3.65914243
32DNA unwinding involved in DNA replication (GO:0006268)3.55281552
33oxidative phosphorylation (GO:0006119)3.54692075
34* establishment of protein localization to membrane (GO:0090150)3.50433258
35DNA strand elongation involved in DNA replication (GO:0006271)3.44659097
36cellular component biogenesis (GO:0044085)3.41207706
37negative regulation of RNA splicing (GO:0033119)3.31815146
38DNA topological change (GO:0006265)3.30644171
39telomere maintenance via semi-conservative replication (GO:0032201)3.28804558
40DNA strand elongation (GO:0022616)3.24587573
41mitotic chromosome condensation (GO:0007076)3.19531799
42* establishment of protein localization to organelle (GO:0072594)3.19428247
43DNA deamination (GO:0045006)3.11255050
44* protein targeting (GO:0006605)3.09845690
45protein localization to kinetochore (GO:0034501)3.04371209
46DNA replication initiation (GO:0006270)3.01801576
47spliceosomal snRNP assembly (GO:0000387)2.94817863
48folic acid-containing compound biosynthetic process (GO:0009396)2.91212474
49* cellular component disassembly (GO:0022411)2.90422773
50spliceosomal complex assembly (GO:0000245)2.89619571
51DNA replication-dependent nucleosome organization (GO:0034723)2.85363374
52DNA replication-dependent nucleosome assembly (GO:0006335)2.85363374
53telomere maintenance via recombination (GO:0000722)2.84815804
54respiratory electron transport chain (GO:0022904)2.83106495
55regulation of RNA export from nucleus (GO:0046831)2.82352749
56mitotic recombination (GO:0006312)2.78648657
57myeloid cell homeostasis (GO:0002262)2.76763871
58chaperone-mediated protein transport (GO:0072321)2.75842133
59electron transport chain (GO:0022900)2.72536507
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71776402
61ribosome biogenesis (GO:0042254)2.71046282
62kinetochore organization (GO:0051383)2.69868130
63protein localization to chromosome, centromeric region (GO:0071459)2.66182375
64telomere maintenance via telomere lengthening (GO:0010833)2.65903550
65chromatin remodeling at centromere (GO:0031055)2.65759274
66ribosome assembly (GO:0042255)2.65045968
67nucleotide-excision repair, DNA gap filling (GO:0006297)2.64250333
68mitotic nuclear envelope disassembly (GO:0007077)2.63564227
69* gene expression (GO:0010467)2.61593063
70nucleobase-containing small molecule interconversion (GO:0015949)2.60236713
71CENP-A containing nucleosome assembly (GO:0034080)2.60144212
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.59077847
73* protein localization to membrane (GO:0072657)2.58474088
74DNA replication checkpoint (GO:0000076)2.57307296
75RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56730557
76mRNA splicing, via spliceosome (GO:0000398)2.56730557
77termination of RNA polymerase II transcription (GO:0006369)2.56503844
78regulation of gene silencing by miRNA (GO:0060964)2.56035845
79regulation of gene silencing by RNA (GO:0060966)2.56035845
80regulation of posttranscriptional gene silencing (GO:0060147)2.56035845
81RNA splicing, via transesterification reactions (GO:0000375)2.55764712
82histone H2B ubiquitination (GO:0033523)2.54289724
83establishment of integrated proviral latency (GO:0075713)2.52932609
84ncRNA processing (GO:0034470)2.49986199
85negative regulation of DNA repair (GO:0045738)2.49232459
86negative regulation of mRNA processing (GO:0050686)2.48814532
87DNA replication-independent nucleosome organization (GO:0034724)2.48662904
88DNA replication-independent nucleosome assembly (GO:0006336)2.48662904
89ribonucleoprotein complex assembly (GO:0022618)2.48298104
90RNA stabilization (GO:0043489)2.48185791
91mRNA stabilization (GO:0048255)2.48185791
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47398917
93regulation of mitochondrial translation (GO:0070129)2.46916358
94histone mRNA metabolic process (GO:0008334)2.46016906
95regulation of protein heterodimerization activity (GO:0043497)2.45398011
96ATP biosynthetic process (GO:0006754)2.44239993
97kinetochore assembly (GO:0051382)2.41241822
98nuclear envelope disassembly (GO:0051081)2.40869477
99membrane disassembly (GO:0030397)2.40869477
100nuclear pore organization (GO:0006999)2.40795483
101regulation of histone H3-K9 methylation (GO:0051570)2.39536334
102regulation of translational initiation (GO:0006446)2.39475731
103* protein localization to organelle (GO:0033365)2.38534116
104aerobic respiration (GO:0009060)2.37911293
105nucleobase biosynthetic process (GO:0046112)2.36545801
106IMP biosynthetic process (GO:0006188)2.34238614
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.34085842
108mitotic metaphase plate congression (GO:0007080)2.33538014
109ribonucleoprotein complex subunit organization (GO:0071826)2.32879931
110mitotic sister chromatid segregation (GO:0000070)2.30616495
111pseudouridine synthesis (GO:0001522)2.30241991
112DNA duplex unwinding (GO:0032508)2.28662194
113transcription-coupled nucleotide-excision repair (GO:0006283)2.28161550
114sister chromatid segregation (GO:0000819)2.27585786
115DNA geometric change (GO:0032392)2.26723935
116chromatin assembly or disassembly (GO:0006333)2.26673286
117purine nucleoside monophosphate biosynthetic process (GO:0009127)2.26600237
118purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.26600237
119ncRNA metabolic process (GO:0034660)2.26474349
120DNA-templated transcription, termination (GO:0006353)2.24944694
121interferon-gamma secretion (GO:0072643)2.24526904
122positive regulation of viral transcription (GO:0050434)2.23642414
123* single-organism cellular localization (GO:1902580)2.22827512
124nuclear pore complex assembly (GO:0051292)2.21822793
125ribonucleoside triphosphate biosynthetic process (GO:0009201)2.21534848
126regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.21128163
127regulation of nucleobase-containing compound transport (GO:0032239)2.20397315
1283-UTR-mediated mRNA stabilization (GO:0070935)2.20313029
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.20173979
130chromatin assembly (GO:0031497)2.18947737
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.18734774
132negative regulation of translational initiation (GO:0045947)2.18723744
133IMP metabolic process (GO:0046040)2.17623118
134heterochromatin organization (GO:0070828)2.17123659
135* viral transcription (GO:0019083)10.1576566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.96467420
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.71788189
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76623195
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.65899255
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.63590519
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.53103400
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.27498280
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08700684
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83783407
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68754785
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.65100976
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64016107
13* XRN2_22483619_ChIP-Seq_HELA_Human2.61311495
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.49204274
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.47415879
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40275143
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26271832
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21156067
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13702224
20TTF2_22483619_ChIP-Seq_HELA_Human2.12138309
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03513161
22VDR_23849224_ChIP-Seq_CD4+_Human1.96094738
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94321318
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86528616
25MYC_22102868_ChIP-Seq_BL_Human1.85626842
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85195698
27DCP1A_22483619_ChIP-Seq_HELA_Human1.82427125
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81710849
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80504227
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78784569
31ELK1_19687146_ChIP-ChIP_HELA_Human1.77387527
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.71953276
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70649830
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.67349204
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.60709456
36AR_21909140_ChIP-Seq_LNCAP_Human1.60024240
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56932602
38* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53644833
39VDR_21846776_ChIP-Seq_THP-1_Human1.51717391
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50089018
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48505880
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44661466
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42732388
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42540267
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39840765
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38879959
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38879959
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38879959
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38370801
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37545582
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36592147
52GABP_19822575_ChIP-Seq_HepG2_Human1.36460434
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32904666
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31920609
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29861338
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28789340
57CIITA_25753668_ChIP-Seq_RAJI_Human1.27868750
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27251576
59ZNF263_19887448_ChIP-Seq_K562_Human1.26367897
60* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26167630
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26026254
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24200648
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23934982
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20371841
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20264643
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.19324891
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18520064
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18367718
69* KDM5A_27292631_Chip-Seq_BREAST_Human1.17994267
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17805424
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.17168961
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15659774
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15334863
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15265729
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13059119
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12723023
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12288351
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11694113
79MYC_18940864_ChIP-ChIP_HL60_Human1.11280641
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10878479
81NCOR1_26117541_ChIP-Seq_K562_Human1.10703985
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09046915
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08906063
84* CHD1_26751641_Chip-Seq_LNCaP_Human1.08845771
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08372250
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08153035
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07891406
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06667105
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06377820
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06190504
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05927755
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05372470
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05037918
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.03076211
95* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02672839
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01840338
97CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01171200
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99770922
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98898988
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.98801351
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98033383
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96035488
103* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95728653
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95175214
105* SPI1_23547873_ChIP-Seq_NB4_Human0.94545536
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94413438
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94357304
108UTX_26944678_Chip-Seq_JUKART_Human0.93902859
109* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93150116
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.91492053
111* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90601708
112* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90540303
113* MAF_26560356_Chip-Seq_TH1_Human0.89157300
114* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88635664
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88279703
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88080218
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.86965392
118* MAF_26560356_Chip-Seq_TH2_Human0.86469824
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86386306
120* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86230209
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85943021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.05074791
2MP0003693_abnormal_embryo_hatching3.35927605
3MP0004957_abnormal_blastocyst_morpholog3.30618735
4MP0010094_abnormal_chromosome_stability2.76072737
5MP0006292_abnormal_olfactory_placode2.65510572
6MP0003111_abnormal_nucleus_morphology2.63357747
7MP0003077_abnormal_cell_cycle2.58249285
8MP0003941_abnormal_skin_development2.41327546
9MP0000566_synostosis2.39697254
10MP0010352_gastrointestinal_tract_polyps2.27926876
11MP0008057_abnormal_DNA_replication2.02631236
12MP0008007_abnormal_cellular_replicative2.02236249
13MP0002396_abnormal_hematopoietic_system2.00361043
14MP0008932_abnormal_embryonic_tissue1.94409183
15MP0002877_abnormal_melanocyte_morpholog1.82947627
16MP0010030_abnormal_orbit_morphology1.80453847
17MP0002796_impaired_skin_barrier1.78601002
18MP0000490_abnormal_crypts_of1.69671778
19MP0000350_abnormal_cell_proliferation1.64706262
20MP0005501_abnormal_skin_physiology1.60703881
21MP0008995_early_reproductive_senescence1.59878196
22MP0008058_abnormal_DNA_repair1.59293020
23MP0003567_abnormal_fetal_cardiomyocyte1.58768519
24MP0000678_abnormal_parathyroid_gland1.58678171
25MP0001730_embryonic_growth_arrest1.54149427
26MP0004381_abnormal_hair_follicle1.45309860
27MP0001346_abnormal_lacrimal_gland1.45154542
28MP0010234_abnormal_vibrissa_follicle1.41989115
29MP0009053_abnormal_anal_canal1.41604610
30MP0000537_abnormal_urethra_morphology1.41526900
31MP0003705_abnormal_hypodermis_morpholog1.39506140
32MP0003786_premature_aging1.38450458
33MP0006054_spinal_hemorrhage1.37516962
34MP0005076_abnormal_cell_differentiation1.37029866
35MP0003136_yellow_coat_color1.36850754
36MP0004808_abnormal_hematopoietic_stem1.35842401
37MP0003763_abnormal_thymus_physiology1.29893593
38MP0009333_abnormal_splenocyte_physiolog1.29835187
39MP0009672_abnormal_birth_weight1.28061644
40MP0004197_abnormal_fetal_growth/weight/1.27542359
41MP0001697_abnormal_embryo_size1.24677352
42MP0002060_abnormal_skin_morphology1.21831885
43MP0002085_abnormal_embryonic_tissue1.21810408
44MP0005023_abnormal_wound_healing1.20338729
45MP0001672_abnormal_embryogenesis/_devel1.19506871
46MP0005380_embryogenesis_phenotype1.19506871
47MP0000383_abnormal_hair_follicle1.19402157
48MP0003453_abnormal_keratinocyte_physiol1.18549735
49MP0002084_abnormal_developmental_patter1.17606139
50MP0003315_abnormal_perineum_morphology1.17394949
51MP0002166_altered_tumor_susceptibility1.17319947
52MP0003123_paternal_imprinting1.17210723
53MP0001216_abnormal_epidermal_layer1.16912327
54MP0002086_abnormal_extraembryonic_tissu1.15105465
55MP0002080_prenatal_lethality1.14649900
56MP0002019_abnormal_tumor_incidence1.14065515
57MP0003186_abnormal_redox_activity1.09877312
58MP0002132_abnormal_respiratory_system1.08605101
59MP0001188_hyperpigmentation1.07244024
60MP0002098_abnormal_vibrissa_morphology1.06997863
61MP0000762_abnormal_tongue_morphology1.06582966
62MP0002088_abnormal_embryonic_growth/wei1.05903320
63MP0003566_abnormal_cell_adhesion1.05300658
64* MP0000703_abnormal_thymus_morphology1.05250151
65MP0003984_embryonic_growth_retardation1.04465383
66MP0010307_abnormal_tumor_latency1.03635131
67MP0002009_preneoplasia1.02969397
68MP0003942_abnormal_urinary_system1.02233125
69MP0000377_abnormal_hair_follicle1.02058910
70MP0000313_abnormal_cell_death1.00199682
71MP0002282_abnormal_trachea_morphology1.00158072
72MP0000467_abnormal_esophagus_morphology0.99757165
73MP0001293_anophthalmia0.99674684
74MP0002938_white_spotting0.99554519
75MP0005666_abnormal_adipose_tissue0.98720378
76MP0010678_abnormal_skin_adnexa0.97084316
77MP0002006_tumorigenesis0.96271052
78MP0000858_altered_metastatic_potential0.95603075
79MP0005275_abnormal_skin_tensile0.95057341
80MP0002249_abnormal_larynx_morphology0.94936126
81MP0000465_gastrointestinal_hemorrhage0.94519283
82MP0001545_abnormal_hematopoietic_system0.93900867
83MP0005397_hematopoietic_system_phenotyp0.93900867
84MP0001881_abnormal_mammary_gland0.93302279
85MP0005503_abnormal_tendon_morphology0.93289973
86MP0002111_abnormal_tail_morphology0.93129906
87* MP0002398_abnormal_bone_marrow0.92830391
88* MP0002722_abnormal_immune_system0.92073368
89MP0005408_hypopigmentation0.90657920
90MP0005174_abnormal_tail_pigmentation0.89562282
91MP0003890_abnormal_embryonic-extraembry0.89254741
92MP0000049_abnormal_middle_ear0.87471275
93MP0002092_abnormal_eye_morphology0.87165227
94MP0009278_abnormal_bone_marrow0.86378053
95MP0004185_abnormal_adipocyte_glucose0.85943677
96MP0000733_abnormal_muscle_development0.85718394
97MP0000477_abnormal_intestine_morphology0.85015343
98MP0000428_abnormal_craniofacial_morphol0.84073745
99MP0010771_integument_phenotype0.82414307
100MP0000750_abnormal_muscle_regeneration0.82325885
101MP0009250_abnormal_appendicular_skeleto0.81825090
102MP0001800_abnormal_humoral_immune0.81278136
103MP0002095_abnormal_skin_pigmentation0.80970608
104MP0002697_abnormal_eye_size0.79787389
105MP0003937_abnormal_limbs/digits/tail_de0.79755437
106MP0009931_abnormal_skin_appearance0.79319395
107MP0000685_abnormal_immune_system0.79293813
108MP0010155_abnormal_intestine_physiology0.79090948
109MP0001286_abnormal_eye_development0.78639804
110MP0000689_abnormal_spleen_morphology0.77987284
111MP0003718_maternal_effect0.77082551
112MP0010630_abnormal_cardiac_muscle0.76824240
113* MP0002429_abnormal_blood_cell0.75450460
114MP0003861_abnormal_nervous_system0.75349046
115MP0001340_abnormal_eyelid_morphology0.75223558
116MP0003385_abnormal_body_wall0.73886805
117MP0009697_abnormal_copulation0.73824754
118MP0002116_abnormal_craniofacial_bone0.73270560
119MP0001873_stomach_inflammation0.72943470
120MP0003436_decreased_susceptibility_to0.72940522
121MP0002405_respiratory_system_inflammati0.72446590
122MP0002932_abnormal_joint_morphology0.71606461
123MP0002210_abnormal_sex_determination0.71568964
124MP0003938_abnormal_ear_development0.71527345
125MP0002233_abnormal_nose_morphology0.69958526
126MP0002114_abnormal_axial_skeleton0.69738601
127MP0000631_abnormal_neuroendocrine_gland0.69597239
128MP0002234_abnormal_pharynx_morphology0.68042305
129MP0003115_abnormal_respiratory_system0.66547028
130MP0001853_heart_inflammation0.66204651
131MP0003935_abnormal_craniofacial_develop0.66069921
132MP0006036_abnormal_mitochondrial_physio0.64789120
133MP0003959_abnormal_lean_body0.61167114
134MP0003755_abnormal_palate_morphology0.61036582
135MP0002081_perinatal_lethality0.60807640
136MP0001145_abnormal_male_reproductive0.59842066
137MP0003806_abnormal_nucleotide_metabolis0.56984710
138MP0009703_decreased_birth_body0.56658074

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.12994863
2Reticulocytopenia (HP:0001896)8.49825004
3Abnormal number of erythroid precursors (HP:0012131)8.00571636
4Macrocytic anemia (HP:0001972)6.28596188
5Pallor (HP:0000980)5.76535685
6Abnormal hemoglobin (HP:0011902)4.30187815
7Colon cancer (HP:0003003)3.54156884
8Thrombocytosis (HP:0001894)3.02860438
9Abnormality of reticulocytes (HP:0004312)3.00914307
10Trismus (HP:0000211)2.91562526
11Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90863343
12Abnormality of the parietal bone (HP:0002696)2.85691438
13Absent thumb (HP:0009777)2.78369361
14Multiple enchondromatosis (HP:0005701)2.78030538
15Congenital, generalized hypertrichosis (HP:0004540)2.74297807
16Stenosis of the external auditory canal (HP:0000402)2.74038903
17Depressed nasal ridge (HP:0000457)2.72133964
18Woolly hair (HP:0002224)2.71834460
19Selective tooth agenesis (HP:0001592)2.70524658
20Lipid accumulation in hepatocytes (HP:0006561)2.60828712
21Respiratory difficulties (HP:0002880)2.59205634
22Truncus arteriosus (HP:0001660)2.49507759
2311 pairs of ribs (HP:0000878)2.47686671
24Acute necrotizing encephalopathy (HP:0006965)2.40670151
25Thick lower lip vermilion (HP:0000179)2.40643262
26Nasolacrimal duct obstruction (HP:0000579)2.40497655
27Increased intramyocellular lipid droplets (HP:0012240)2.39167826
28Fragile nails (HP:0001808)2.36788437
29Migraine (HP:0002076)2.36429971
30Abnormal mitochondria in muscle tissue (HP:0008316)2.35767349
31Abnormality of cochlea (HP:0000375)2.34890717
32Progressive muscle weakness (HP:0003323)2.34483478
33Atresia of the external auditory canal (HP:0000413)2.33760358
34Seborrheic dermatitis (HP:0001051)2.27303146
35Breast hypoplasia (HP:0003187)2.24907716
36Microvesicular hepatic steatosis (HP:0001414)2.22897145
37Short middle phalanx of the 5th finger (HP:0004220)2.21967259
38Oral leukoplakia (HP:0002745)2.21803166
39Duplication of thumb phalanx (HP:0009942)2.20816444
40Ependymoma (HP:0002888)2.19225585
41Calcaneovalgus deformity (HP:0001848)2.17830567
42Concave nail (HP:0001598)2.17253279
43Basal cell carcinoma (HP:0002671)2.15515107
44Hypoplasia of the radius (HP:0002984)2.14881193
45Triphalangeal thumb (HP:0001199)2.13800081
46Asplenia (HP:0001746)2.13550414
47Aplastic anemia (HP:0001915)2.12884765
48Missing ribs (HP:0000921)2.11115150
49Proximal placement of thumb (HP:0009623)2.09239109
50Ankyloglossia (HP:0010296)2.08852972
51Pseudobulbar signs (HP:0002200)2.05355238
52Abnormality of the lacrimal duct (HP:0011481)2.05315332
53Birth length less than 3rd percentile (HP:0003561)2.05087298
54Medulloblastoma (HP:0002885)2.04380464
55Hyperthyroidism (HP:0000836)2.03268507
56Rhabdomyosarcoma (HP:0002859)2.02588025
57Neoplasm of the pancreas (HP:0002894)2.00907568
58Acute lymphatic leukemia (HP:0006721)2.00686359
59Aplasia/Hypoplasia of the spleen (HP:0010451)1.97761067
60Septo-optic dysplasia (HP:0100842)1.97673306
61Sparse lateral eyebrow (HP:0005338)1.97238468
62Acute encephalopathy (HP:0006846)1.96961180
63Morphological abnormality of the inner ear (HP:0011390)1.95359087
64Deviation of the thumb (HP:0009603)1.94981579
65Increased muscle lipid content (HP:0009058)1.94552322
66Deformed tarsal bones (HP:0008119)1.91197326
67Agnosia (HP:0010524)1.90503266
68Partial duplication of the phalanx of hand (HP:0009999)1.89449103
69Overlapping toe (HP:0001845)1.88316579
70Renal Fanconi syndrome (HP:0001994)1.87862902
71Glossoptosis (HP:0000162)1.87416639
72Cleft eyelid (HP:0000625)1.84897220
73Abnormality of the calcaneus (HP:0008364)1.83609780
74Mitochondrial inheritance (HP:0001427)1.83081827
75Abnormal number of incisors (HP:0011064)1.81493096
76Absent radius (HP:0003974)1.80860703
77Reticulocytosis (HP:0001923)1.77728039
78Squamous cell carcinoma (HP:0002860)1.77704407
79Hypoparathyroidism (HP:0000829)1.77279176
80Broad distal phalanx of finger (HP:0009836)1.76816659
81Abnormality of the nasolacrimal system (HP:0000614)1.76172356
82Rough bone trabeculation (HP:0100670)1.74940652
83Biliary tract neoplasm (HP:0100574)1.74624564
84Patellar aplasia (HP:0006443)1.72835110
85Aplasia/Hypoplasia of the patella (HP:0006498)1.72138697
86Premature ovarian failure (HP:0008209)1.71871340
87Esophageal atresia (HP:0002032)1.70594903
88Poikiloderma (HP:0001029)1.70050266
89Progressive macrocephaly (HP:0004481)1.69625713
90Cerebral edema (HP:0002181)1.69305304
91Bicuspid aortic valve (HP:0001647)1.68794753
92Deep palmar crease (HP:0006191)1.67905045
93Partial duplication of thumb phalanx (HP:0009944)1.67570400
94Increased nuchal translucency (HP:0010880)1.67505830
95Acute myeloid leukemia (HP:0004808)1.67457551
96Myelodysplasia (HP:0002863)1.67289817
97Hypertensive crisis (HP:0100735)1.66553152
98IgM deficiency (HP:0002850)1.66207767
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66103426
100Maternal diabetes (HP:0009800)1.66031921
101Sparse eyelashes (HP:0000653)1.65193103
102Aplasia involving forearm bones (HP:0009822)1.64856445
103Absent forearm bone (HP:0003953)1.64856445
104Bowel incontinence (HP:0002607)1.64111325
105Neoplasm of the colon (HP:0100273)1.63728249
106Rectal prolapse (HP:0002035)1.63411174
107Abnormality of the tricuspid valve (HP:0001702)1.62032257
108Microretrognathia (HP:0000308)1.61367210
109Horseshoe kidney (HP:0000085)1.61087994
110Hypotrichosis (HP:0001006)1.61050898
111Progressive external ophthalmoplegia (HP:0000590)1.61036912
112Supernumerary ribs (HP:0005815)1.60667160
113Gout (HP:0001997)1.60412547
114Ridged nail (HP:0001807)1.58651573
115Amaurosis fugax (HP:0100576)1.58558353
116Aplasia cutis congenita (HP:0001057)1.58545133
117Pili torti (HP:0003777)1.57552122
118Blepharitis (HP:0000498)1.56733779
119Colitis (HP:0002583)1.56379297
120Increased hepatocellular lipid droplets (HP:0006565)1.55471360
121Lip pit (HP:0100267)1.55401137
122Exertional dyspnea (HP:0002875)1.54893771
123Abnormal large intestine physiology (HP:0012700)1.54882322
124Increased density of long bones (HP:0006392)1.54270263
125Aplasia/Hypoplasia of the thymus (HP:0010515)1.53619286
126Homocystinuria (HP:0002156)1.53325438
127Abnormality of homocysteine metabolism (HP:0010919)1.53325438
128Abnormality of the fetal cardiovascular system (HP:0010948)1.52367048
129Abnormal umbilical cord blood vessels (HP:0011403)1.52367048
130Single umbilical artery (HP:0001195)1.52367048
131Abnormality of the preputium (HP:0100587)1.52358001
132Increased CSF lactate (HP:0002490)1.52212103
133Exercise intolerance (HP:0003546)1.51779882
134Milia (HP:0001056)1.51662380
135Overriding aorta (HP:0002623)1.51094165
136Tracheoesophageal fistula (HP:0002575)1.50839678
137Down-sloping shoulders (HP:0200021)1.50558230
138Chromsome breakage (HP:0040012)1.49324523
139Abnormality of the axillary hair (HP:0100134)1.49071651
140Abnormality of secondary sexual hair (HP:0009888)1.49071651
141Deep philtrum (HP:0002002)1.48756523
142Dysphonia (HP:0001618)1.48333819
143Premature skin wrinkling (HP:0100678)1.47514680
144Leukodystrophy (HP:0002415)1.47235749
145Entropion (HP:0000621)1.47158804
146Premature graying of hair (HP:0002216)1.47012849
147Onycholysis (HP:0001806)1.46165342
148Septate vagina (HP:0001153)1.45497103
149Turricephaly (HP:0000262)1.45429887
150Carpal bone hypoplasia (HP:0001498)1.44525257
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.43910637
152Short thumb (HP:0009778)1.43837080
153Abnormality of small intestinal villus morphology (HP:0011472)1.43811908
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.43747237
155Decreased activity of mitochondrial respiratory chain (HP:0008972)1.43747237
156Adenoma sebaceum (HP:0009720)1.43491653
157Angiofibromas (HP:0010615)1.43491653
158Neoplasm of striated muscle (HP:0009728)1.43260142
159Preauricular skin tag (HP:0000384)1.42580856
160Abnormality of the umbilical cord (HP:0010881)1.42291351
161Meckel diverticulum (HP:0002245)1.42236394
162Short nose (HP:0003196)1.41991548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.45914944
2TLK13.80482769
3EEF2K3.18632407
4RPS6KB23.07300475
5SMG13.03001396
6VRK22.92672583
7WEE12.77701464
8BUB12.57323861
9LRRK22.47920245
10CDC72.25521690
11MAP3K102.18799192
12PRPF4B2.03199918
13TGFBR11.99181499
14SRPK11.91997268
15EIF2AK11.90434322
16NEK21.88130629
17TAF11.86598981
18MST41.86335628
19PKN21.84426942
20ICK1.82102842
21PASK1.68686670
22MKNK11.63524054
23DYRK31.60249278
24FLT31.54032496
25STK101.52345219
26TESK21.47927727
27VRK11.47206279
28AURKB1.47203681
29CDK71.47147529
30PIM21.47098565
31MAPKAPK31.46167106
32ILK1.46154202
33LATS21.36577120
34EPHA21.32959979
35RPS6KA41.26941951
36TTK1.22231754
37CDK41.20919753
38MAP3K81.18743026
39ACVR1B1.14904454
40PLK11.12500715
41MAP4K11.11847772
42BRSK21.11439351
43TYRO31.11419778
44PAK41.09945883
45MKNK21.08449636
46CDK121.07210990
47PIK3CG1.06719463
48PIM11.04174323
49TSSK61.04109104
50CDK61.03028227
51KSR20.97965791
52STK160.96185187
53PLK40.96110179
54ATR0.94352841
55SCYL20.90840825
56STK40.90295412
57BLK0.88007471
58KDR0.87945743
59BRAF0.87552780
60PAK20.87378767
61RIPK40.87189279
62MAP3K130.86768662
63NEK10.83889308
64MAP3K30.83801272
65EPHB20.82944588
66TRIB30.82303670
67AURKA0.78999692
68CSNK2A20.78013308
69MAP2K20.78004822
70CHEK10.75592645
71BTK0.74029280
72CLK10.73724416
73RPS6KA50.73453134
74GRK60.73081201
75CHEK20.71217324
76EIF2AK30.70659614
77CSNK1E0.70359199
78PNCK0.69920626
79DMPK0.69215621
80SIK10.68933392
81CDK190.68929942
82MAP2K30.68517239
83ALK0.68474169
84FGFR40.68393666
85BRSK10.68369565
86BRD40.67751080
87MAPK150.66322701
88TEC0.65887469
89MST1R0.63822638
90CDK30.62062804
91KIT0.61842957
92DAPK30.61521430
93IRAK30.60638766
94DYRK1B0.60486086
95RPS6KC10.58574923
96RPS6KL10.58574923
97CDK10.57995787
98CSNK2A10.57160039
99ARAF0.56584499
100PAK10.55912605
101ATM0.55337066
102TYK20.55183827
103CDK20.54029370
104CSF1R0.52714151
105IKBKB0.50658046
106CDK11A0.48901397
107CDK80.47772815
108CCNB10.47325610
109TESK10.46871715
110MAPKAPK50.46568597
111PLK30.46380536
112CDK90.45611711
113TTN0.45321188
114LATS10.45236003
115BMX0.44586825
116STK30.43549099
117WNK10.43302698
118RPS6KA60.43137020
119NME10.43111099
120PDGFRA0.42725162
121AKT20.42661267
122NEK90.41978729
123YES10.41861605
124MAP3K110.41423235
125IRAK20.41285156
126PTK60.41064826
127RPS6KA10.41060119
128DYRK20.40858824
129NLK0.40265188
130PBK0.39766086
131ZAP700.39384309
132LCK0.36958115
133RPS6KB10.36807390
134MTOR0.36758423
135TGFBR20.36468003
136CAMK1D0.36325199
137EIF2AK20.36267866
138STK240.35860612
139MAPKAPK20.35256174
140PRKCI0.34433533
141TRPM70.34335665
142RAF10.30815403
143MAPK140.30519281

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.84880048
2DNA replication_Homo sapiens_hsa030303.89748521
3Mismatch repair_Homo sapiens_hsa034303.40246082
4Spliceosome_Homo sapiens_hsa030403.16725249
5RNA polymerase_Homo sapiens_hsa030202.67361850
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64223775
7RNA transport_Homo sapiens_hsa030132.36587369
8Nucleotide excision repair_Homo sapiens_hsa034202.34651805
9Homologous recombination_Homo sapiens_hsa034402.28412119
10Proteasome_Homo sapiens_hsa030502.18990538
11One carbon pool by folate_Homo sapiens_hsa006702.16454522
12Base excision repair_Homo sapiens_hsa034102.10495332
13Pyrimidine metabolism_Homo sapiens_hsa002401.89009832
14Cell cycle_Homo sapiens_hsa041101.81273359
15Systemic lupus erythematosus_Homo sapiens_hsa053221.67779239
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60765653
17Fanconi anemia pathway_Homo sapiens_hsa034601.57809267
18Non-homologous end-joining_Homo sapiens_hsa034501.48114407
19p53 signaling pathway_Homo sapiens_hsa041151.43094185
20RNA degradation_Homo sapiens_hsa030181.39296934
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.36741460
22mRNA surveillance pathway_Homo sapiens_hsa030151.31313903
23Cardiac muscle contraction_Homo sapiens_hsa042601.28389217
24Basal transcription factors_Homo sapiens_hsa030221.22894968
25Sulfur relay system_Homo sapiens_hsa041221.22819821
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09192086
27Antigen processing and presentation_Homo sapiens_hsa046121.05339007
28Small cell lung cancer_Homo sapiens_hsa052221.03145914
29Epstein-Barr virus infection_Homo sapiens_hsa051691.02176680
30Viral carcinogenesis_Homo sapiens_hsa052030.99241146
31Herpes simplex infection_Homo sapiens_hsa051680.97835049
32Primary immunodeficiency_Homo sapiens_hsa053400.96246838
33Protein export_Homo sapiens_hsa030600.90239269
34Basal cell carcinoma_Homo sapiens_hsa052170.87715158
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86925964
36HTLV-I infection_Homo sapiens_hsa051660.86733809
37Renal cell carcinoma_Homo sapiens_hsa052110.85744252
38Pancreatic cancer_Homo sapiens_hsa052120.84953697
39MicroRNAs in cancer_Homo sapiens_hsa052060.83092201
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81398446
41Parkinsons disease_Homo sapiens_hsa050120.81379149
42Thyroid cancer_Homo sapiens_hsa052160.78239938
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77258524
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76193075
45Huntingtons disease_Homo sapiens_hsa050160.74527164
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73933211
47Pyruvate metabolism_Homo sapiens_hsa006200.71626028
48Purine metabolism_Homo sapiens_hsa002300.71339788
49Bladder cancer_Homo sapiens_hsa052190.69088611
50Carbon metabolism_Homo sapiens_hsa012000.68941864
51Chronic myeloid leukemia_Homo sapiens_hsa052200.66744889
52Oxidative phosphorylation_Homo sapiens_hsa001900.65041446
53Notch signaling pathway_Homo sapiens_hsa043300.63322232
54Pentose phosphate pathway_Homo sapiens_hsa000300.61545435
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61407826
56Hematopoietic cell lineage_Homo sapiens_hsa046400.61003567
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58762118
58Acute myeloid leukemia_Homo sapiens_hsa052210.58677956
59Hippo signaling pathway_Homo sapiens_hsa043900.58017770
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.57119823
61Apoptosis_Homo sapiens_hsa042100.56947897
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55905565
63Glutathione metabolism_Homo sapiens_hsa004800.55746120
64Folate biosynthesis_Homo sapiens_hsa007900.55560352
65TGF-beta signaling pathway_Homo sapiens_hsa043500.55484473
66Alcoholism_Homo sapiens_hsa050340.53600977
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.50575567
68VEGF signaling pathway_Homo sapiens_hsa043700.50080256
69Pathways in cancer_Homo sapiens_hsa052000.49957441
70Measles_Homo sapiens_hsa051620.49764110
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49429506
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.48744585
73Legionellosis_Homo sapiens_hsa051340.48541049
74Hedgehog signaling pathway_Homo sapiens_hsa043400.48523877
75Viral myocarditis_Homo sapiens_hsa054160.48121240
76Adherens junction_Homo sapiens_hsa045200.47369749
77Colorectal cancer_Homo sapiens_hsa052100.45158425
78Proteoglycans in cancer_Homo sapiens_hsa052050.43829915
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.43680022
80Hepatitis B_Homo sapiens_hsa051610.43595783
81B cell receptor signaling pathway_Homo sapiens_hsa046620.42981042
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42406711
83mTOR signaling pathway_Homo sapiens_hsa041500.42075972
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42067068
85Endometrial cancer_Homo sapiens_hsa052130.40992465
86ECM-receptor interaction_Homo sapiens_hsa045120.40032234
87ErbB signaling pathway_Homo sapiens_hsa040120.39117954
88Prostate cancer_Homo sapiens_hsa052150.38894291
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38192210
90Toxoplasmosis_Homo sapiens_hsa051450.37753970
91Prion diseases_Homo sapiens_hsa050200.37301150
92HIF-1 signaling pathway_Homo sapiens_hsa040660.37016501
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.36958926
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35905597
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.35415976
96Alzheimers disease_Homo sapiens_hsa050100.35137419
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35025405
98T cell receptor signaling pathway_Homo sapiens_hsa046600.32461315
99Melanoma_Homo sapiens_hsa052180.30471000
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30447028
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.29585673
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28993084
103Selenocompound metabolism_Homo sapiens_hsa004500.28747186
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28596792
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28138461
106Shigellosis_Homo sapiens_hsa051310.27698710
107Tight junction_Homo sapiens_hsa045300.27308315
108Arachidonic acid metabolism_Homo sapiens_hsa005900.26701634
109Non-small cell lung cancer_Homo sapiens_hsa052230.26605414
110Biosynthesis of amino acids_Homo sapiens_hsa012300.26197456
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26158730
112Leishmaniasis_Homo sapiens_hsa051400.25934965
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.25675586
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24908812
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24782656
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24407826
117Fructose and mannose metabolism_Homo sapiens_hsa000510.23473833
118Wnt signaling pathway_Homo sapiens_hsa043100.23343246
119Influenza A_Homo sapiens_hsa051640.22764971
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22166239
121Insulin signaling pathway_Homo sapiens_hsa049100.21964235
122Metabolic pathways_Homo sapiens_hsa011000.21721257
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19820714
124Glioma_Homo sapiens_hsa052140.18976598
125Melanogenesis_Homo sapiens_hsa049160.18328888
126N-Glycan biosynthesis_Homo sapiens_hsa005100.17122791
127Vitamin digestion and absorption_Homo sapiens_hsa049770.14154557
128Choline metabolism in cancer_Homo sapiens_hsa052310.13540436
129Prolactin signaling pathway_Homo sapiens_hsa049170.13129657
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10802968
131Arginine and proline metabolism_Homo sapiens_hsa003300.10141837

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