RPL21P44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.78489133
2ATP synthesis coupled proton transport (GO:0015986)4.43072331
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.43072331
4nonmotile primary cilium assembly (GO:0035058)4.04039602
5viral transcription (GO:0019083)3.94139253
6serotonin metabolic process (GO:0042428)3.89552114
7translational termination (GO:0006415)3.86799930
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84657767
9indolalkylamine metabolic process (GO:0006586)3.83479729
10primary amino compound metabolic process (GO:1901160)3.76877820
11ribosomal small subunit assembly (GO:0000028)3.73392523
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70563526
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68957061
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.68957061
15NADH dehydrogenase complex assembly (GO:0010257)3.68957061
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.64643347
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62665258
18protein complex biogenesis (GO:0070271)3.60683681
19cotranslational protein targeting to membrane (GO:0006613)3.59178656
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58389855
21ribosomal large subunit biogenesis (GO:0042273)3.56359858
22protein targeting to ER (GO:0045047)3.54421563
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48116911
24activated T cell proliferation (GO:0050798)3.44764019
25lactate metabolic process (GO:0006089)3.44362237
26indole-containing compound metabolic process (GO:0042430)3.41228222
27platelet dense granule organization (GO:0060155)3.39189734
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38240625
29protein localization to endoplasmic reticulum (GO:0070972)3.37912954
30tryptophan catabolic process (GO:0006569)3.35953257
31indole-containing compound catabolic process (GO:0042436)3.35953257
32indolalkylamine catabolic process (GO:0046218)3.35953257
33negative regulation of T cell differentiation in thymus (GO:0033085)3.35492962
34positive regulation of T cell apoptotic process (GO:0070234)3.30354514
35negative regulation of mast cell activation (GO:0033004)3.29597154
36DNA deamination (GO:0045006)3.29125093
37substrate-independent telencephalic tangential migration (GO:0021826)3.24900106
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.24900106
39mitochondrial respiratory chain complex assembly (GO:0033108)3.22088865
40protein neddylation (GO:0045116)3.22068732
41negative regulation of leukocyte chemotaxis (GO:0002689)3.21099815
42translational elongation (GO:0006414)3.16361897
43ribonucleoprotein complex disassembly (GO:0032988)3.10702312
44electron transport chain (GO:0022900)3.09622957
45respiratory electron transport chain (GO:0022904)3.05752405
46tryptophan metabolic process (GO:0006568)3.02960676
47somite development (GO:0061053)3.01686741
48kynurenine metabolic process (GO:0070189)3.00303220
49regulation of cilium movement (GO:0003352)2.99633684
50ATP biosynthetic process (GO:0006754)2.99204287
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98985679
52GTP biosynthetic process (GO:0006183)2.98293417
53organelle disassembly (GO:1903008)2.96082820
54response to pheromone (GO:0019236)2.92145112
55protein-cofactor linkage (GO:0018065)2.91566946
56purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91169592
57anterograde synaptic vesicle transport (GO:0048490)2.91131566
58L-fucose catabolic process (GO:0042355)2.89932375
59fucose catabolic process (GO:0019317)2.89932375
60L-fucose metabolic process (GO:0042354)2.89932375
61cell proliferation in forebrain (GO:0021846)2.87853406
62chaperone-mediated protein transport (GO:0072321)2.86051026
63protein localization to cilium (GO:0061512)2.82352558
64regulation of action potential (GO:0098900)2.80767526
65cellular protein complex disassembly (GO:0043624)2.77193006
66intraciliary transport (GO:0042073)2.75488759
67negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.75384715
68estrogen biosynthetic process (GO:0006703)2.73766414
69positive regulation of lymphocyte apoptotic process (GO:0070230)2.69004535
70head development (GO:0060322)2.68807117
71detection of light stimulus involved in visual perception (GO:0050908)2.67462576
72detection of light stimulus involved in sensory perception (GO:0050962)2.67462576
73cAMP catabolic process (GO:0006198)2.65721313
74viral life cycle (GO:0019058)2.65392873
75hydrogen ion transmembrane transport (GO:1902600)2.63019397
76protein polyglutamylation (GO:0018095)2.62415293
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.62100275
78water-soluble vitamin biosynthetic process (GO:0042364)2.61414080
79proton transport (GO:0015992)2.58733448
80translational initiation (GO:0006413)2.58203725
81cellular biogenic amine catabolic process (GO:0042402)2.58094824
82amine catabolic process (GO:0009310)2.58094824
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51757356
84hydrogen transport (GO:0006818)2.51703674
85axoneme assembly (GO:0035082)2.51424205
86photoreceptor cell maintenance (GO:0045494)2.50310635
87epithelial cilium movement (GO:0003351)2.48734022
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47532404
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47532404
90maturation of SSU-rRNA (GO:0030490)2.46935072
91translation (GO:0006412)2.46624377
92protein prenylation (GO:0018342)2.44176487
93prenylation (GO:0097354)2.44176487
94replication fork processing (GO:0031297)2.43540198
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.42593382
96DNA demethylation (GO:0080111)2.42570424
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41243245
98response to nitrosative stress (GO:0051409)2.40484956
99sulfation (GO:0051923)2.40181577
100DNA double-strand break processing (GO:0000729)2.39297152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.11009073
2VDR_22108803_ChIP-Seq_LS180_Human3.06035557
3ZNF274_21170338_ChIP-Seq_K562_Hela2.83607646
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.59637456
5IGF1R_20145208_ChIP-Seq_DFB_Human2.48045044
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.34715767
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27663331
8EZH2_22144423_ChIP-Seq_EOC_Human2.25824607
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21221937
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20535000
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.14905163
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11990156
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.04092242
14FUS_26573619_Chip-Seq_HEK293_Human1.99961414
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96505859
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92455157
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89060667
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86674476
19EWS_26573619_Chip-Seq_HEK293_Human1.85703335
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77787539
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77772804
22P300_19829295_ChIP-Seq_ESCs_Human1.76768931
23TP53_22573176_ChIP-Seq_HFKS_Human1.75299210
24ELK1_19687146_ChIP-ChIP_HELA_Human1.75127439
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72981893
26ER_23166858_ChIP-Seq_MCF-7_Human1.68485138
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66716311
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65959000
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.62040218
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61070424
31BCAT_22108803_ChIP-Seq_LS180_Human1.59871124
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54487751
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54277145
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50043708
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50043708
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48652381
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47947073
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43678526
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43514355
40VDR_23849224_ChIP-Seq_CD4+_Human1.40380371
41SOX2_19829295_ChIP-Seq_ESCs_Human1.40286211
42NANOG_19829295_ChIP-Seq_ESCs_Human1.40286211
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39247341
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.39085261
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39031491
46IRF1_19129219_ChIP-ChIP_H3396_Human1.38929061
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.35080332
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35078147
49SMAD4_21799915_ChIP-Seq_A2780_Human1.30578505
50* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30509295
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.29920097
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.28512784
53* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28511609
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.28182394
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28182394
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27935097
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27614054
58AR_25329375_ChIP-Seq_VCAP_Human1.26829779
59TCF4_22108803_ChIP-Seq_LS180_Human1.26739814
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26337372
61MYC_18940864_ChIP-ChIP_HL60_Human1.26087699
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.26015537
63TAF15_26573619_Chip-Seq_HEK293_Human1.25884329
64REST_21632747_ChIP-Seq_MESCs_Mouse1.24636059
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24520401
66CBP_20019798_ChIP-Seq_JUKART_Human1.23908531
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23908531
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21694503
69TCF4_23295773_ChIP-Seq_U87_Human1.21689445
70RNF2_27304074_Chip-Seq_NSC_Mouse1.18804324
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.16963423
72AR_20517297_ChIP-Seq_VCAP_Human1.15672508
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.15160498
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.14492653
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13803213
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13525541
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.13353219
78NCOR_22424771_ChIP-Seq_293T_Human1.09725449
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09515221
80MYC_19829295_ChIP-Seq_ESCs_Human1.09311248
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09195869
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.08548272
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08348651
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.08001859
85STAT3_23295773_ChIP-Seq_U87_Human1.07711672
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05695908
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05490076
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03895587
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03371056
90* HOXB7_26014856_ChIP-Seq_BT474_Human1.02890768
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.02817735
92TP53_16413492_ChIP-PET_HCT116_Human1.02580863
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.01962788
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01558404
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.00718001
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00606335
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.00566081
98P53_22387025_ChIP-Seq_ESCs_Mouse1.00229988
99ERG_20517297_ChIP-Seq_VCAP_Human0.99886209
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.99781425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.82929583
2MP0006292_abnormal_olfactory_placode3.72961641
3MP0003787_abnormal_imprinting3.51008613
4MP0008789_abnormal_olfactory_epithelium2.81230569
5MP0004742_abnormal_vestibular_system2.55019445
6MP0002102_abnormal_ear_morphology2.39498123
7MP0004885_abnormal_endolymph2.29712749
8MP0004142_abnormal_muscle_tone2.18943066
9MP0002736_abnormal_nociception_after2.14916292
10MP0008875_abnormal_xenobiotic_pharmacok2.13472063
11MP0001968_abnormal_touch/_nociception2.11751457
12MP0008877_abnormal_DNA_methylation2.10971202
13MP0003121_genomic_imprinting2.10925573
14MP0002837_dystrophic_cardiac_calcinosis2.09419268
15MP0005551_abnormal_eye_electrophysiolog2.03052367
16MP0005394_taste/olfaction_phenotype2.02919353
17MP0005499_abnormal_olfactory_system2.02919353
18MP0006072_abnormal_retinal_apoptosis1.90169500
19MP0008872_abnormal_physiological_respon1.90142645
20MP0000372_irregular_coat_pigmentation1.87976847
21MP0001835_abnormal_antigen_presentation1.86615023
22MP0001485_abnormal_pinna_reflex1.85395789
23MP0006276_abnormal_autonomic_nervous1.79706745
24MP0003646_muscle_fatigue1.76148980
25MP0003122_maternal_imprinting1.56098500
26MP0002272_abnormal_nervous_system1.55137666
27MP0000427_abnormal_hair_cycle1.55009106
28MP0003195_calcinosis1.52332943
29MP0001501_abnormal_sleep_pattern1.49002666
30MP0003011_delayed_dark_adaptation1.46004368
31MP0005379_endocrine/exocrine_gland_phen1.43642503
32MP0004147_increased_porphyrin_level1.40823669
33MP0001919_abnormal_reproductive_system1.38646154
34MP0005377_hearing/vestibular/ear_phenot1.37488238
35MP0003878_abnormal_ear_physiology1.37488238
36MP0001440_abnormal_grooming_behavior1.35108201
37MP0002638_abnormal_pupillary_reflex1.34177342
38MP0005253_abnormal_eye_physiology1.33368784
39MP0000383_abnormal_hair_follicle1.28968254
40MP0001986_abnormal_taste_sensitivity1.28939792
41MP0004145_abnormal_muscle_electrophysio1.28937245
42MP0005389_reproductive_system_phenotype1.25477027
43MP0005645_abnormal_hypothalamus_physiol1.23008326
44MP0002163_abnormal_gland_morphology1.22711579
45MP0005367_renal/urinary_system_phenotyp1.21954089
46MP0000516_abnormal_urinary_system1.21954089
47MP0002938_white_spotting1.21793106
48MP0001529_abnormal_vocalization1.20994666
49MP0001486_abnormal_startle_reflex1.20879755
50MP0009745_abnormal_behavioral_response1.17164652
51MP0002653_abnormal_ependyma_morphology1.16050729
52MP0001905_abnormal_dopamine_level1.15507448
53MP0005646_abnormal_pituitary_gland1.13876845
54MP0005195_abnormal_posterior_eye1.12226070
55MP0001293_anophthalmia1.11837289
56MP0000049_abnormal_middle_ear1.09859112
57MP0002557_abnormal_social/conspecific_i1.08809604
58MP0005174_abnormal_tail_pigmentation1.08660839
59MP0005671_abnormal_response_to1.08655726
60MP0009046_muscle_twitch1.05870428
61MP0002572_abnormal_emotion/affect_behav1.02429293
62MP0003123_paternal_imprinting1.01179836
63MP0001873_stomach_inflammation1.01046115
64MP0001764_abnormal_homeostasis1.00300956
65MP0000569_abnormal_digit_pigmentation0.99090153
66MP0001970_abnormal_pain_threshold0.98748151
67MP0000026_abnormal_inner_ear0.98263811
68MP0003880_abnormal_central_pattern0.98016425
69MP0002095_abnormal_skin_pigmentation0.97567132
70MP0000631_abnormal_neuroendocrine_gland0.97326282
71MP0002876_abnormal_thyroid_physiology0.96332374
72MP0001963_abnormal_hearing_physiology0.95672782
73MP0000778_abnormal_nervous_system0.94768724
74MP0002735_abnormal_chemical_nociception0.91909936
75MP0003186_abnormal_redox_activity0.88868545
76MP0005423_abnormal_somatic_nervous0.88836535
77MP0005410_abnormal_fertilization0.88655915
78MP0000647_abnormal_sebaceous_gland0.88518973
79MP0002752_abnormal_somatic_nervous0.86809076
80MP0008058_abnormal_DNA_repair0.86134536
81MP0009053_abnormal_anal_canal0.85986812
82MP0009785_altered_susceptibility_to0.84754333
83MP0009764_decreased_sensitivity_to0.83973044
84MP0005387_immune_system_phenotype0.82143606
85MP0001790_abnormal_immune_system0.82143606
86MP0000230_abnormal_systemic_arterial0.81439769
87MP0001984_abnormal_olfaction0.80956246
88MP0006054_spinal_hemorrhage0.80797513
89MP0002160_abnormal_reproductive_system0.80328673
90MP0002734_abnormal_mechanical_nocicepti0.77404892
91MP0008775_abnormal_heart_ventricle0.76904423
92MP0002184_abnormal_innervation0.76543969
93MP0001800_abnormal_humoral_immune0.74184550
94MP0005386_behavior/neurological_phenoty0.73519261
95MP0004924_abnormal_behavior0.73519261
96MP0002067_abnormal_sensory_capabilities0.72904453
97MP0002064_seizures0.72812285
98MP0002210_abnormal_sex_determination0.72516297
99MP0003633_abnormal_nervous_system0.70904936
100MP0002148_abnormal_hypersensitivity_rea0.69661931

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.16697263
2Abnormality of midbrain morphology (HP:0002418)4.15942319
3Molar tooth sign on MRI (HP:0002419)4.15942319
4Progressive macrocephaly (HP:0004481)3.71426065
5Mitochondrial inheritance (HP:0001427)3.60960774
6Pancreatic fibrosis (HP:0100732)3.58234786
7Abnormal mitochondria in muscle tissue (HP:0008316)3.42272255
8Acute encephalopathy (HP:0006846)3.39569120
9Pancreatic cysts (HP:0001737)3.37350145
10Increased hepatocellular lipid droplets (HP:0006565)3.34308461
11Type II lissencephaly (HP:0007260)3.27472268
12Medial flaring of the eyebrow (HP:0010747)3.17674984
13Increased CSF lactate (HP:0002490)3.11951639
14True hermaphroditism (HP:0010459)3.08806413
15Lipid accumulation in hepatocytes (HP:0006561)3.03616893
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.97005165
17Absent/shortened dynein arms (HP:0200106)2.97005165
18Congenital stationary night blindness (HP:0007642)2.86950206
19Nephronophthisis (HP:0000090)2.86246899
20Exertional dyspnea (HP:0002875)2.76643365
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74977648
223-Methylglutaconic aciduria (HP:0003535)2.68928587
23Abnormal rod and cone electroretinograms (HP:0008323)2.65981883
24Cerebral edema (HP:0002181)2.65411350
25Cerebellar dysplasia (HP:0007033)2.65290191
26Renal Fanconi syndrome (HP:0001994)2.62069600
27Hepatocellular necrosis (HP:0001404)2.60482084
28Reticulocytopenia (HP:0001896)2.57906167
29Congenital, generalized hypertrichosis (HP:0004540)2.57888117
30Abolished electroretinogram (ERG) (HP:0000550)2.57215579
31Colon cancer (HP:0003003)2.53790274
32Gait imbalance (HP:0002141)2.53636851
33Optic disc pallor (HP:0000543)2.52215191
34Congenital primary aphakia (HP:0007707)2.51830327
35Abnormality of the renal medulla (HP:0100957)2.44870105
36Type 2 muscle fiber atrophy (HP:0003554)2.38084669
37Abnormality of the renal cortex (HP:0011035)2.37624028
38Chronic hepatic failure (HP:0100626)2.26271680
39Nephrogenic diabetes insipidus (HP:0009806)2.25240351
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24612813
41Hyperventilation (HP:0002883)2.23896495
42Decreased central vision (HP:0007663)2.20969494
43Stomatitis (HP:0010280)2.20308856
44Hepatic necrosis (HP:0002605)2.15405326
45Abnormality of DNA repair (HP:0003254)2.12861615
46Increased corneal curvature (HP:0100692)2.12737935
47Keratoconus (HP:0000563)2.12737935
48Optic nerve hypoplasia (HP:0000609)2.11756704
49Neoplasm of the adrenal cortex (HP:0100641)2.05606158
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.03909867
51Abnormal respiratory epithelium morphology (HP:0012253)2.03138403
52Abnormal respiratory motile cilium morphology (HP:0005938)2.03138403
53Abnormal drinking behavior (HP:0030082)2.03011799
54Polydipsia (HP:0001959)2.03011799
55Cystic liver disease (HP:0006706)2.02412414
56Abnormal ciliary motility (HP:0012262)2.01745476
57Severe muscular hypotonia (HP:0006829)1.98782570
58Pendular nystagmus (HP:0012043)1.96374407
59Attenuation of retinal blood vessels (HP:0007843)1.96205242
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93981561
61Sclerocornea (HP:0000647)1.93580792
62Abnormality of renal resorption (HP:0011038)1.92995547
63Leukodystrophy (HP:0002415)1.92061597
64Renal cortical cysts (HP:0000803)1.90948150
65Febrile seizures (HP:0002373)1.90498411
66Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89543146
67Metaphyseal dysplasia (HP:0100255)1.89141616
68Male pseudohermaphroditism (HP:0000037)1.87253224
69Increased serum lactate (HP:0002151)1.86700497
70Lactic acidosis (HP:0003128)1.86141650
71IgG deficiency (HP:0004315)1.85942645
72Postaxial foot polydactyly (HP:0001830)1.85033549
73Increased intramyocellular lipid droplets (HP:0012240)1.83508300
74Vaginal atresia (HP:0000148)1.83108783
75Postaxial hand polydactyly (HP:0001162)1.81909470
76Genital tract atresia (HP:0001827)1.81517609
77Macrocytic anemia (HP:0001972)1.80747831
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.80629415
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79995340
80Constricted visual fields (HP:0001133)1.79739526
81Stenosis of the external auditory canal (HP:0000402)1.79295475
82Abnormality of cells of the erythroid lineage (HP:0012130)1.79020717
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.77131261
84Hypoplasia of the fovea (HP:0007750)1.77131261
85Anencephaly (HP:0002323)1.76787145
86Growth hormone deficiency (HP:0000824)1.75782830
87Inability to walk (HP:0002540)1.74618550
88Poor coordination (HP:0002370)1.74468340
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73035462
90Abnormal hemoglobin (HP:0011902)1.72078523
91Amblyopia (HP:0000646)1.70986742
92Thyroiditis (HP:0100646)1.70647611
93Anophthalmia (HP:0000528)1.70414863
94Focal seizures (HP:0007359)1.70332948
95Tubular atrophy (HP:0000092)1.69740477
96Septo-optic dysplasia (HP:0100842)1.68713894
97Enlarged kidneys (HP:0000105)1.68358508
98Retinal dysplasia (HP:0007973)1.68322345
99Hypoplasia of the ulna (HP:0003022)1.68134506
100Absent thumb (HP:0009777)1.68002686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK23.60253716
2FRK3.29764944
3WEE12.93819202
4NUAK12.74238214
5ACVR1B2.68640251
6BMPR1B2.66076654
7MAP4K22.36667410
8MST42.30732713
9TAOK32.28343602
10TNIK2.25473927
11VRK22.22283366
12ZAK2.18656094
13ADRBK22.14807328
14GRK12.00263765
15WNK31.99113596
16VRK11.91804631
17WNK41.88952239
18CDK81.86886099
19TXK1.86060805
20DYRK21.85098813
21MAP3K121.80713637
22TLK11.74273084
23CASK1.60656373
24PINK11.53678424
25STK161.47787044
26TIE11.37176120
27TAF11.32420342
28INSRR1.25128773
29BRSK11.19999663
30PIK3CA1.18578938
31BMPR21.17807276
32PNCK1.17477802
33MKNK21.15533081
34TEC1.14255161
35EPHB21.12422902
36HIPK21.11171756
37OXSR11.10040282
38CDK191.03722538
39KIT1.02271524
40MAPK130.95732852
41PRKCE0.91028216
42MAPKAPK50.87131091
43PAK30.82713474
44STK390.80832085
45PLK30.76719418
46ITK0.76279274
47PHKG10.75998168
48PHKG20.75998168
49TYRO30.74341093
50CSNK1G30.73777418
51NTRK20.72662564
52ADRBK10.71477903
53FLT30.70985258
54CSNK1G20.70569655
55CSNK1G10.70234711
56TGFBR10.69894704
57EPHA40.67417414
58MUSK0.66965912
59MKNK10.65658475
60MAP2K60.64263163
61PRKCG0.63981329
62OBSCN0.61376493
63MARK30.60515560
64CAMKK20.59390995
65NLK0.57668708
66AKT30.57277623
67GRK50.56906049
68IKBKB0.55368974
69CSNK1A1L0.53866756
70IKBKE0.51907466
71MYLK0.51054628
72WNK10.50026516
73EIF2AK20.49569972
74PRKACA0.49528548
75STK110.49311266
76PLK20.48391083
77CDK40.47897646
78CAMK2A0.46518429
79PRKCZ0.45774026
80EIF2AK30.45607514
81PRKG10.44484411
82ERBB30.44105742
83TRIM280.43583872
84BCR0.41483658
85RPS6KA50.41149007
86FGFR20.40959338
87PRKCI0.40880734
88PRKCA0.40854526
89MARK10.39453692
90PBK0.39441392
91CDK90.38738996
92DYRK1A0.38580099
93AURKB0.37551705
94BTK0.36598418
95JAK30.36533178
96FES0.35943026
97CSNK2A10.35579856
98CAMK10.34857269
99DAPK30.34755722
100CAMK2D0.34273354

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.69383976
2Oxidative phosphorylation_Homo sapiens_hsa001903.34724245
3Asthma_Homo sapiens_hsa053103.18523426
4Protein export_Homo sapiens_hsa030603.12342854
5Parkinsons disease_Homo sapiens_hsa050122.69118615
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.49287651
7Allograft rejection_Homo sapiens_hsa053302.26249337
8Autoimmune thyroid disease_Homo sapiens_hsa053202.17354314
9Graft-versus-host disease_Homo sapiens_hsa053322.14702939
10Homologous recombination_Homo sapiens_hsa034402.03751867
11Caffeine metabolism_Homo sapiens_hsa002322.02179249
12Proteasome_Homo sapiens_hsa030501.99768741
13Cardiac muscle contraction_Homo sapiens_hsa042601.96796811
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92363601
15Type I diabetes mellitus_Homo sapiens_hsa049401.90727028
16RNA polymerase_Homo sapiens_hsa030201.85929731
17Alzheimers disease_Homo sapiens_hsa050101.82923694
18Huntingtons disease_Homo sapiens_hsa050161.80095102
19Basal transcription factors_Homo sapiens_hsa030221.71696714
20Nucleotide excision repair_Homo sapiens_hsa034201.70072306
21Tryptophan metabolism_Homo sapiens_hsa003801.65239780
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63601780
23Linoleic acid metabolism_Homo sapiens_hsa005911.62640797
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58849002
25Nitrogen metabolism_Homo sapiens_hsa009101.57888688
26Phototransduction_Homo sapiens_hsa047441.47035828
27Fanconi anemia pathway_Homo sapiens_hsa034601.44685854
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41959342
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41503956
30RNA degradation_Homo sapiens_hsa030181.33140112
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33032717
32Mismatch repair_Homo sapiens_hsa034301.32115633
33One carbon pool by folate_Homo sapiens_hsa006701.29267794
34Butanoate metabolism_Homo sapiens_hsa006501.25947263
35Propanoate metabolism_Homo sapiens_hsa006401.24372002
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22341520
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20777217
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19839697
39Olfactory transduction_Homo sapiens_hsa047401.17715846
40Primary immunodeficiency_Homo sapiens_hsa053401.17078381
41Rheumatoid arthritis_Homo sapiens_hsa053231.11280177
42Antigen processing and presentation_Homo sapiens_hsa046121.10879263
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.10808434
44Chemical carcinogenesis_Homo sapiens_hsa052041.06571939
45Regulation of autophagy_Homo sapiens_hsa041401.03953013
46Nicotine addiction_Homo sapiens_hsa050330.99310508
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94138849
48Ether lipid metabolism_Homo sapiens_hsa005650.93457109
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92111138
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81998483
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79038907
52Collecting duct acid secretion_Homo sapiens_hsa049660.78674732
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.78659291
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75914012
55Morphine addiction_Homo sapiens_hsa050320.74042260
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73791836
57Insulin secretion_Homo sapiens_hsa049110.70386712
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.67326771
59Arachidonic acid metabolism_Homo sapiens_hsa005900.66992736
60Retinol metabolism_Homo sapiens_hsa008300.66188038
61beta-Alanine metabolism_Homo sapiens_hsa004100.65742044
62Viral myocarditis_Homo sapiens_hsa054160.64091595
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64019647
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62764139
65Peroxisome_Homo sapiens_hsa041460.60535099
66Fat digestion and absorption_Homo sapiens_hsa049750.58192817
67Purine metabolism_Homo sapiens_hsa002300.57213877
68Staphylococcus aureus infection_Homo sapiens_hsa051500.53930162
69Non-homologous end-joining_Homo sapiens_hsa034500.52860721
70Glycerolipid metabolism_Homo sapiens_hsa005610.52143546
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49618754
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48988640
73Serotonergic synapse_Homo sapiens_hsa047260.47829039
74ABC transporters_Homo sapiens_hsa020100.47704488
75Metabolic pathways_Homo sapiens_hsa011000.46920633
76Fatty acid elongation_Homo sapiens_hsa000620.46660516
77RNA transport_Homo sapiens_hsa030130.46287451
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44896228
79Salivary secretion_Homo sapiens_hsa049700.44556037
80Hematopoietic cell lineage_Homo sapiens_hsa046400.43940334
81Circadian entrainment_Homo sapiens_hsa047130.42494907
82Glutamatergic synapse_Homo sapiens_hsa047240.41813988
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41234332
84Taste transduction_Homo sapiens_hsa047420.40765423
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40736474
86Selenocompound metabolism_Homo sapiens_hsa004500.40614605
87Mineral absorption_Homo sapiens_hsa049780.39182587
88Pyrimidine metabolism_Homo sapiens_hsa002400.39155019
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39118339
90Basal cell carcinoma_Homo sapiens_hsa052170.38727775
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34593914
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33604369
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32574316
94Glutathione metabolism_Homo sapiens_hsa004800.32099945
95GABAergic synapse_Homo sapiens_hsa047270.31248432
96Ovarian steroidogenesis_Homo sapiens_hsa049130.27896621
97African trypanosomiasis_Homo sapiens_hsa051430.25870483
98Systemic lupus erythematosus_Homo sapiens_hsa053220.25082985
99Calcium signaling pathway_Homo sapiens_hsa040200.23681805
100Amphetamine addiction_Homo sapiens_hsa050310.23661704

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