RPL21P135

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.60837153
2DNA deamination (GO:0045006)4.72660471
3tryptophan catabolic process (GO:0006569)4.26583060
4indole-containing compound catabolic process (GO:0042436)4.26583060
5indolalkylamine catabolic process (GO:0046218)4.26583060
6fucose catabolic process (GO:0019317)4.14712082
7L-fucose metabolic process (GO:0042354)4.14712082
8L-fucose catabolic process (GO:0042355)4.14712082
9platelet dense granule organization (GO:0060155)4.03359150
10water-soluble vitamin biosynthetic process (GO:0042364)3.92052923
11indolalkylamine metabolic process (GO:0006586)3.91860473
12response to pheromone (GO:0019236)3.90963733
13kynurenine metabolic process (GO:0070189)3.84001914
14tryptophan metabolic process (GO:0006568)3.68163806
15protein complex biogenesis (GO:0070271)3.53903507
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36334033
17axoneme assembly (GO:0035082)3.32469151
18respiratory chain complex IV assembly (GO:0008535)3.22960439
19negative regulation of telomere maintenance (GO:0032205)3.22319286
20piRNA metabolic process (GO:0034587)3.21698267
21mitochondrial respiratory chain complex assembly (GO:0033108)3.21010938
22cellular biogenic amine catabolic process (GO:0042402)3.19591247
23amine catabolic process (GO:0009310)3.19591247
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19001980
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.19001980
26NADH dehydrogenase complex assembly (GO:0010257)3.19001980
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17132735
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17132735
29protein neddylation (GO:0045116)3.14741527
30cytidine deamination (GO:0009972)3.14243636
31cytidine metabolic process (GO:0046087)3.14243636
32cytidine catabolic process (GO:0006216)3.14243636
33detection of light stimulus involved in sensory perception (GO:0050962)3.14202194
34detection of light stimulus involved in visual perception (GO:0050908)3.14202194
35cellular ketone body metabolic process (GO:0046950)3.11812982
36negative regulation of mast cell activation (GO:0033004)3.11037524
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08462190
38cytochrome complex assembly (GO:0017004)3.07491883
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03903422
40indole-containing compound metabolic process (GO:0042430)3.01232256
41mannosylation (GO:0097502)2.98337913
42epithelial cilium movement (GO:0003351)2.96449295
43preassembly of GPI anchor in ER membrane (GO:0016254)2.93603823
44gamma-aminobutyric acid transport (GO:0015812)2.92775570
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87901355
46dopamine transport (GO:0015872)2.87900376
47ketone body metabolic process (GO:1902224)2.86807984
48cornea development in camera-type eye (GO:0061303)2.86780027
49behavioral response to ethanol (GO:0048149)2.79722724
50protein polyglutamylation (GO:0018095)2.79419954
51pyrimidine ribonucleoside catabolic process (GO:0046133)2.76153168
52kidney morphogenesis (GO:0060993)2.76129877
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75831131
54neural tube formation (GO:0001841)2.71480512
55positive regulation of defense response to virus by host (GO:0002230)2.71268872
56parturition (GO:0007567)2.63173880
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62544638
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60277702
59ATP synthesis coupled proton transport (GO:0015986)2.59865825
60energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59865825
61peptidyl-histidine modification (GO:0018202)2.59489099
62retinal cone cell development (GO:0046549)2.57772333
63DNA methylation involved in gamete generation (GO:0043046)2.57402968
64regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57264253
65synaptic transmission, cholinergic (GO:0007271)2.57184272
66positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.56261185
67protein localization to cilium (GO:0061512)2.54514781
68ubiquinone biosynthetic process (GO:0006744)2.53905894
69primary amino compound metabolic process (GO:1901160)2.53886233
70benzene-containing compound metabolic process (GO:0042537)2.53474702
71sulfation (GO:0051923)2.51709348
72regulation of action potential (GO:0098900)2.51092623
73aromatic amino acid family catabolic process (GO:0009074)2.50830161
74regulation of memory T cell differentiation (GO:0043380)2.50772141
75positive regulation of fatty acid transport (GO:2000193)2.50745235
76rhodopsin mediated signaling pathway (GO:0016056)2.49757084
77reciprocal meiotic recombination (GO:0007131)2.49343794
78reciprocal DNA recombination (GO:0035825)2.49343794
79regulation of neurotransmitter uptake (GO:0051580)2.48550074
80adenosine metabolic process (GO:0046085)2.48291802
81adaptation of signaling pathway (GO:0023058)2.47336229
82transmission of nerve impulse (GO:0019226)2.46640609
83nephron tubule morphogenesis (GO:0072078)2.42361776
84nephron epithelium morphogenesis (GO:0072088)2.42361776
85regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.41332297
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41153336
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40794666
88neuronal action potential (GO:0019228)2.39735701
89endoderm formation (GO:0001706)2.39657985
90GPI anchor metabolic process (GO:0006505)2.37906714
91photoreceptor cell development (GO:0042461)2.37669449
92S-adenosylmethionine metabolic process (GO:0046500)2.35682621
93cilium movement (GO:0003341)2.35254134
94negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34506195
95multicellular organism reproduction (GO:0032504)2.34104085
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.33643786
97somite development (GO:0061053)2.33174694
98nonmotile primary cilium assembly (GO:0035058)2.33093371
99cilium morphogenesis (GO:0060271)2.32357358
100ubiquinone metabolic process (GO:0006743)2.32111335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.66388827
2VDR_22108803_ChIP-Seq_LS180_Human3.42326860
3EZH2_22144423_ChIP-Seq_EOC_Human2.71484011
4GBX2_23144817_ChIP-Seq_PC3_Human2.55165550
5IGF1R_20145208_ChIP-Seq_DFB_Human2.51826817
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51015241
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.43402705
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34786019
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27405940
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14191094
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13938944
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08730189
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05772812
14TAF15_26573619_Chip-Seq_HEK293_Human1.97530253
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96748483
16ER_23166858_ChIP-Seq_MCF-7_Human1.94215036
17EWS_26573619_Chip-Seq_HEK293_Human1.94214876
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.92046542
19P300_19829295_ChIP-Seq_ESCs_Human1.91322624
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88760162
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87499951
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80373746
23BCAT_22108803_ChIP-Seq_LS180_Human1.67597040
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63056472
25MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61661451
26FUS_26573619_Chip-Seq_HEK293_Human1.61587150
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61322033
28TP53_22573176_ChIP-Seq_HFKS_Human1.61080207
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58527080
30IRF1_19129219_ChIP-ChIP_H3396_Human1.56653446
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.53702323
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.51288477
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51288477
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50032055
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49836909
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47976087
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.47843681
38CBP_20019798_ChIP-Seq_JUKART_Human1.47328122
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47328122
40NANOG_19829295_ChIP-Seq_ESCs_Human1.46827095
41SOX2_19829295_ChIP-Seq_ESCs_Human1.46827095
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43343987
43MYC_18940864_ChIP-ChIP_HL60_Human1.43196623
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41952181
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40213851
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39863292
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.37373850
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34276294
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34205956
50AR_25329375_ChIP-Seq_VCAP_Human1.32259503
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31195209
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.30467544
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29739679
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28868817
55AR_20517297_ChIP-Seq_VCAP_Human1.28188248
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.28089662
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.27056587
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.26524281
59NCOR_22424771_ChIP-Seq_293T_Human1.24895737
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23749047
61TCF4_23295773_ChIP-Seq_U87_Human1.23342409
62TCF4_22108803_ChIP-Seq_LS180_Human1.22784308
63SMAD4_21799915_ChIP-Seq_A2780_Human1.22739689
64STAT3_23295773_ChIP-Seq_U87_Human1.22385829
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21235770
66ELK1_19687146_ChIP-ChIP_HELA_Human1.18713086
67REST_21632747_ChIP-Seq_MESCs_Mouse1.17984837
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17921453
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.17679994
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17178096
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16707678
72VDR_23849224_ChIP-Seq_CD4+_Human1.16405227
73HOXB7_26014856_ChIP-Seq_BT474_Human1.16380107
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16199388
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13102830
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12883701
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.12313882
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11673050
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.11619709
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.11619268
81RUNX2_22187159_ChIP-Seq_PCA_Human1.11243128
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.10873825
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.10871208
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10728117
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10271948
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10271948
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09371796
88CDX2_22108803_ChIP-Seq_LS180_Human1.07022898
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05986009
90RNF2_27304074_Chip-Seq_NSC_Mouse1.04495336
91P53_22387025_ChIP-Seq_ESCs_Mouse1.04195760
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03742734
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03064226
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.02883476
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02726233
96NANOG_20526341_ChIP-Seq_ESCs_Human1.00235971
97TAF2_19829295_ChIP-Seq_ESCs_Human1.00229137
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99428090
99STAT3_18555785_Chip-Seq_ESCs_Mouse0.99385653
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98207801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.98141303
2MP0002102_abnormal_ear_morphology2.88611070
3MP0002837_dystrophic_cardiac_calcinosis2.57986961
4MP0003195_calcinosis2.55613806
5MP0005551_abnormal_eye_electrophysiolog2.43653006
6MP0005646_abnormal_pituitary_gland2.39726330
7MP0004885_abnormal_endolymph2.36643177
8MP0008872_abnormal_physiological_respon2.30634957
9MP0004147_increased_porphyrin_level2.21878560
10MP0002876_abnormal_thyroid_physiology2.20762133
11MP0003787_abnormal_imprinting2.17968203
12MP0003646_muscle_fatigue2.15905041
13MP0006072_abnormal_retinal_apoptosis2.10377217
14MP0008875_abnormal_xenobiotic_pharmacok2.00281113
15MP0001968_abnormal_touch/_nociception1.99206815
16MP0006292_abnormal_olfactory_placode1.92672313
17MP0000372_irregular_coat_pigmentation1.90806704
18MP0001986_abnormal_taste_sensitivity1.89233480
19MP0005645_abnormal_hypothalamus_physiol1.86213657
20MP0002163_abnormal_gland_morphology1.85309119
21MP0002736_abnormal_nociception_after1.82194094
22MP0004142_abnormal_muscle_tone1.80008280
23MP0009745_abnormal_behavioral_response1.78851381
24MP0005253_abnormal_eye_physiology1.73606368
25MP0001485_abnormal_pinna_reflex1.69738873
26MP0001501_abnormal_sleep_pattern1.68071795
27MP0003880_abnormal_central_pattern1.58706299
28MP0002138_abnormal_hepatobiliary_system1.55677101
29MP0002638_abnormal_pupillary_reflex1.54495982
30MP0002272_abnormal_nervous_system1.52185597
31MP0005671_abnormal_response_to1.51465868
32MP0009046_muscle_twitch1.50600669
33MP0004742_abnormal_vestibular_system1.50012761
34MP0002653_abnormal_ependyma_morphology1.49420843
35MP0003011_delayed_dark_adaptation1.49396912
36MP0005379_endocrine/exocrine_gland_phen1.49354517
37MP0000631_abnormal_neuroendocrine_gland1.47597761
38MP0001486_abnormal_startle_reflex1.45028644
39MP0003283_abnormal_digestive_organ1.44786934
40MP0004043_abnormal_pH_regulation1.44478748
41MP0004145_abnormal_muscle_electrophysio1.43773171
42MP0001905_abnormal_dopamine_level1.36029332
43MP0001529_abnormal_vocalization1.34228599
44MP0003252_abnormal_bile_duct1.33934740
45MP0003878_abnormal_ear_physiology1.32788496
46MP0005377_hearing/vestibular/ear_phenot1.32788496
47MP0000427_abnormal_hair_cycle1.26650630
48MP0000569_abnormal_digit_pigmentation1.25461183
49MP0005389_reproductive_system_phenotype1.22311821
50MP0005085_abnormal_gallbladder_physiolo1.20457350
51MP0005075_abnormal_melanosome_morpholog1.18072745
52MP0006276_abnormal_autonomic_nervous1.17208851
53MP0002938_white_spotting1.17090929
54MP0003136_yellow_coat_color1.16117759
55MP0005084_abnormal_gallbladder_morpholo1.15921646
56MP0002160_abnormal_reproductive_system1.15742805
57MP0001970_abnormal_pain_threshold1.11316999
58MP0001984_abnormal_olfaction1.11252740
59MP0002733_abnormal_thermal_nociception1.10162103
60MP0010386_abnormal_urinary_bladder1.09667061
61MP0002572_abnormal_emotion/affect_behav1.08295152
62MP0002557_abnormal_social/conspecific_i1.08284660
63MP0004133_heterotaxia1.07911006
64MP0005365_abnormal_bile_salt1.03742202
65MP0002234_abnormal_pharynx_morphology1.01980426
66MP0002254_reproductive_system_inflammat1.00322173
67MP0002064_seizures0.99398312
68MP0001919_abnormal_reproductive_system0.97741512
69MP0002095_abnormal_skin_pigmentation0.96716170
70MP0001764_abnormal_homeostasis0.94099606
71MP0005386_behavior/neurological_phenoty0.93430412
72MP0004924_abnormal_behavior0.93430412
73MP0000026_abnormal_inner_ear0.93311510
74MP0005174_abnormal_tail_pigmentation0.92445647
75MP0003718_maternal_effect0.91015039
76MP0001963_abnormal_hearing_physiology0.90687724
77MP0002067_abnormal_sensory_capabilities0.89706739
78MP0005636_abnormal_mineral_homeostasis0.89567909
79MP0006036_abnormal_mitochondrial_physio0.89332374
80MP0005195_abnormal_posterior_eye0.86781156
81MP0008995_early_reproductive_senescence0.86707011
82MP0009764_decreased_sensitivity_to0.86001313
83MP0002693_abnormal_pancreas_physiology0.85527271
84MP0002229_neurodegeneration0.85260527
85MP0001835_abnormal_antigen_presentation0.85186645
86MP0000230_abnormal_systemic_arterial0.85135027
87MP0002735_abnormal_chemical_nociception0.84740604
88MP0003137_abnormal_impulse_conducting0.84389079
89MP0010329_abnormal_lipoprotein_level0.83014526
90MP0005332_abnormal_amino_acid0.80062858
91MP0005410_abnormal_fertilization0.79483446
92MP0002063_abnormal_learning/memory/cond0.78031887
93MP0004215_abnormal_myocardial_fiber0.77462518
94MP0002752_abnormal_somatic_nervous0.75874574
95MP0005360_urolithiasis0.75624261
96MP0003635_abnormal_synaptic_transmissio0.74490543
97MP0008058_abnormal_DNA_repair0.74473326
98MP0008775_abnormal_heart_ventricle0.73194197
99MP0002751_abnormal_autonomic_nervous0.72305399
100MP0004019_abnormal_vitamin_homeostasis0.70932731

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.32913312
2Congenital stationary night blindness (HP:0007642)4.14398261
3Molar tooth sign on MRI (HP:0002419)3.86242284
4Abnormality of midbrain morphology (HP:0002418)3.86242284
5Pancreatic fibrosis (HP:0100732)3.82855839
6True hermaphroditism (HP:0010459)3.72962737
7Abnormality of the renal cortex (HP:0011035)3.72093549
8Nephronophthisis (HP:0000090)3.49018084
9Abnormality of the renal medulla (HP:0100957)3.21003287
10Abnormal rod and cone electroretinograms (HP:0008323)3.08680954
11Attenuation of retinal blood vessels (HP:0007843)3.03340186
12Acute necrotizing encephalopathy (HP:0006965)3.01000206
13Type II lissencephaly (HP:0007260)2.99301449
14Pendular nystagmus (HP:0012043)2.94797986
15Renal cortical cysts (HP:0000803)2.90619891
16Medial flaring of the eyebrow (HP:0010747)2.80780747
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77678985
18Mitochondrial inheritance (HP:0001427)2.76634938
19Tubular atrophy (HP:0000092)2.75767582
20Progressive macrocephaly (HP:0004481)2.70181465
21Methylmalonic acidemia (HP:0002912)2.65992094
22Abolished electroretinogram (ERG) (HP:0000550)2.64157354
23Increased CSF lactate (HP:0002490)2.62730252
24Acute encephalopathy (HP:0006846)2.60224114
25Abnormal mitochondria in muscle tissue (HP:0008316)2.56146411
26Keratoconus (HP:0000563)2.49558108
27Increased corneal curvature (HP:0100692)2.49558108
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47503980
29Abnormality of alanine metabolism (HP:0010916)2.47503980
30Hyperalaninemia (HP:0003348)2.47503980
31Cystic liver disease (HP:0006706)2.47410190
32Hepatocellular necrosis (HP:0001404)2.40674944
33Decreased central vision (HP:0007663)2.36454313
34Methylmalonic aciduria (HP:0012120)2.35706623
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35642355
36Abnormal drinking behavior (HP:0030082)2.32969385
37Polydipsia (HP:0001959)2.32969385
38Inability to walk (HP:0002540)2.31921226
39Hepatic necrosis (HP:0002605)2.31229567
403-Methylglutaconic aciduria (HP:0003535)2.30527095
41Gaze-evoked nystagmus (HP:0000640)2.29954123
42Hyperventilation (HP:0002883)2.28493970
43Congenital, generalized hypertrichosis (HP:0004540)2.27603633
44Sclerocornea (HP:0000647)2.26489144
45Optic disc pallor (HP:0000543)2.24532094
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.22043870
47Polyuria (HP:0000103)2.21214358
48Large for gestational age (HP:0001520)2.16101500
49Chronic hepatic failure (HP:0100626)2.15140318
50IgG deficiency (HP:0004315)2.14121372
51Stomatitis (HP:0010280)2.13312928
52Hypoproteinemia (HP:0003075)2.10714709
53Asplenia (HP:0001746)2.07595218
54Lissencephaly (HP:0001339)2.07147478
55Progressive inability to walk (HP:0002505)2.06165998
56Thyroiditis (HP:0100646)2.05550650
57Intestinal atresia (HP:0011100)2.05495826
58Progressive cerebellar ataxia (HP:0002073)2.01752383
59Furrowed tongue (HP:0000221)1.99400214
60Lipid accumulation in hepatocytes (HP:0006561)1.97229935
61Congenital hepatic fibrosis (HP:0002612)1.97089685
62Gait imbalance (HP:0002141)1.97029682
63Nephrogenic diabetes insipidus (HP:0009806)1.95720451
64Congenital primary aphakia (HP:0007707)1.93982179
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.93612411
66Absent/shortened dynein arms (HP:0200106)1.93612411
67Hypothermia (HP:0002045)1.91859690
68Increased serum lactate (HP:0002151)1.90299093
69Increased hepatocellular lipid droplets (HP:0006565)1.90237727
70Male pseudohermaphroditism (HP:0000037)1.87827380
71Bile duct proliferation (HP:0001408)1.85800182
72Abnormal biliary tract physiology (HP:0012439)1.85800182
73Metabolic alkalosis (HP:0200114)1.85512392
74Genetic anticipation (HP:0003743)1.84822086
75Anencephaly (HP:0002323)1.84678990
76Postaxial foot polydactyly (HP:0001830)1.83871412
77Optic nerve hypoplasia (HP:0000609)1.80920841
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.80135966
79Constricted visual fields (HP:0001133)1.79820273
80Abnormal urine output (HP:0012590)1.79620597
81Elevated erythrocyte sedimentation rate (HP:0003565)1.79580896
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79094496
83Chorioretinal atrophy (HP:0000533)1.78173136
84Disproportionate short-trunk short stature (HP:0003521)1.74531404
85Agitation (HP:0000713)1.73546016
86Abnormal albumin level (HP:0012116)1.73420227
87Hypoalbuminemia (HP:0003073)1.73420227
88Bony spicule pigmentary retinopathy (HP:0007737)1.73100422
89Cerebral edema (HP:0002181)1.72621920
90Cerebellar dysplasia (HP:0007033)1.72564835
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.72105598
92Hypomagnesemia (HP:0002917)1.69801485
93Aplasia/hypoplasia of the uterus (HP:0008684)1.68789771
94Retinal dysplasia (HP:0007973)1.66186200
95Renal Fanconi syndrome (HP:0001994)1.65168990
96Hyperglycinemia (HP:0002154)1.65140970
97Abnormality of vitamin B metabolism (HP:0004340)1.64348122
98Lactic acidosis (HP:0003128)1.64254501
99Stomach cancer (HP:0012126)1.63398603
100Congenital sensorineural hearing impairment (HP:0008527)1.63073509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.83067855
2ADRBK23.52188346
3MAP4K22.97123526
4GRK12.93257059
5TAOK32.85842504
6ZAK2.78521015
7BMPR1B2.65744340
8NUAK12.50739923
9TXK2.50033951
10PINK12.41502310
11WNK42.38358216
12WNK32.17485581
13INSRR1.92318381
14CAMKK21.68122664
15ACVR1B1.65876169
16MAP3K41.54380364
17TLK11.49197618
18OXSR11.45426690
19TRIM281.39069131
20MAPK131.35207192
21MUSK1.34482434
22BCKDK1.34196653
23TEC1.26645537
24PAK31.24242563
25MST41.22843726
26MKNK21.19202866
27TNIK1.16875171
28DAPK21.09266236
29STK391.08174162
30ADRBK11.06371145
31DYRK20.99646780
32CSNK1G10.94778277
33VRK20.94765220
34ITK0.94046962
35EIF2AK30.90423504
36KDR0.90034074
37PRKCE0.89424978
38TIE10.89216017
39CSNK1G30.87625383
40BCR0.87453403
41CDK190.86489047
42VRK10.84786036
43CSNK1G20.84556198
44PLK20.83520928
45ERBB30.82187331
46CASK0.81701581
47PRKCG0.80838258
48PRKCQ0.78582809
49PHKG10.78540398
50PHKG20.78540398
51TGFBR10.76358323
52IKBKB0.73019505
53PIK3CA0.72886380
54CSNK1A1L0.68630187
55GRK70.67666225
56NTRK20.65691182
57STK160.65280402
58MAP3K120.64054753
59MAP4K10.62048139
60NEK20.60036455
61TNK20.58985856
62NTRK30.58763189
63NLK0.58177201
64PASK0.57355663
65PTK2B0.57263100
66MAP2K60.57130477
67STK38L0.56860181
68FLT30.56728808
69MKNK10.56428350
70KIT0.56299218
71MAP2K70.56265922
72FGFR20.55681358
73CAMK10.53504868
74PLK30.52905959
75PRKACA0.51923809
76CCNB10.51535064
77CAMK2A0.51337700
78SYK0.51026691
79MARK10.49721457
80STK30.46314882
81GRK60.46142596
82EPHA40.45392005
83RPS6KA50.45188729
84GRK50.44716571
85PRKCA0.41942229
86TAF10.40610551
87MAPKAPK50.40231867
88PKN10.40093311
89CSNK1A10.39686162
90BRSK20.39674997
91CAMKK10.39181033
92OBSCN0.38873969
93PRKCI0.38853991
94BTK0.37472681
95IGF1R0.34187749
96PRKAA20.33406651
97PLK40.31875784
98LCK0.30978543
99LYN0.30468908
100MAPKAPK30.30000371

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.84937264
2Oxidative phosphorylation_Homo sapiens_hsa001902.79249880
3Protein export_Homo sapiens_hsa030602.50791651
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39314213
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28855483
6Linoleic acid metabolism_Homo sapiens_hsa005912.19697212
7Parkinsons disease_Homo sapiens_hsa050122.17261406
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08891650
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02912071
10Nitrogen metabolism_Homo sapiens_hsa009102.01550026
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.99285880
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91396691
13Butanoate metabolism_Homo sapiens_hsa006501.87519649
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78202442
15Primary immunodeficiency_Homo sapiens_hsa053401.72812632
16Caffeine metabolism_Homo sapiens_hsa002321.72473768
17Tryptophan metabolism_Homo sapiens_hsa003801.72322908
18Homologous recombination_Homo sapiens_hsa034401.70482856
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.68960160
20Proteasome_Homo sapiens_hsa030501.64347474
21RNA polymerase_Homo sapiens_hsa030201.61879360
22Nicotine addiction_Homo sapiens_hsa050331.58975137
23Asthma_Homo sapiens_hsa053101.56911781
24Selenocompound metabolism_Homo sapiens_hsa004501.54221720
25Ether lipid metabolism_Homo sapiens_hsa005651.51893684
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50883254
27Propanoate metabolism_Homo sapiens_hsa006401.50505526
28Basal transcription factors_Homo sapiens_hsa030221.48606698
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44740146
30Cardiac muscle contraction_Homo sapiens_hsa042601.33101512
31Alzheimers disease_Homo sapiens_hsa050101.31442129
32Allograft rejection_Homo sapiens_hsa053301.29867495
33Peroxisome_Homo sapiens_hsa041461.29282568
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.28998098
35Huntingtons disease_Homo sapiens_hsa050161.28420889
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28268557
37Type I diabetes mellitus_Homo sapiens_hsa049401.26918600
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26012534
39Chemical carcinogenesis_Homo sapiens_hsa052041.24089003
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21682769
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21441774
42Autoimmune thyroid disease_Homo sapiens_hsa053201.21099499
43Olfactory transduction_Homo sapiens_hsa047401.19433010
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15138559
45RNA degradation_Homo sapiens_hsa030181.14279344
46Sulfur metabolism_Homo sapiens_hsa009201.13080979
47Morphine addiction_Homo sapiens_hsa050321.12769612
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.11345500
49Regulation of autophagy_Homo sapiens_hsa041401.09523528
50One carbon pool by folate_Homo sapiens_hsa006701.07968323
51Taste transduction_Homo sapiens_hsa047421.07705496
52Retinol metabolism_Homo sapiens_hsa008301.04823249
53Graft-versus-host disease_Homo sapiens_hsa053321.03881614
54Fanconi anemia pathway_Homo sapiens_hsa034601.03869274
55Arachidonic acid metabolism_Homo sapiens_hsa005900.99409980
56Collecting duct acid secretion_Homo sapiens_hsa049660.97057519
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94941103
58Ribosome_Homo sapiens_hsa030100.91294317
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89640461
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88292730
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86408982
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80917808
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79984577
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79043395
65Insulin secretion_Homo sapiens_hsa049110.77191093
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76815588
67ABC transporters_Homo sapiens_hsa020100.76652037
68Serotonergic synapse_Homo sapiens_hsa047260.76452184
69GABAergic synapse_Homo sapiens_hsa047270.75535313
70Purine metabolism_Homo sapiens_hsa002300.72318908
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68749087
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66086006
73Glutamatergic synapse_Homo sapiens_hsa047240.65919989
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65617331
75Circadian entrainment_Homo sapiens_hsa047130.64228238
76Rheumatoid arthritis_Homo sapiens_hsa053230.64069531
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64044078
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63124030
79Metabolic pathways_Homo sapiens_hsa011000.62373895
80Fat digestion and absorption_Homo sapiens_hsa049750.61451894
81Ovarian steroidogenesis_Homo sapiens_hsa049130.61140962
82beta-Alanine metabolism_Homo sapiens_hsa004100.60955796
83Hematopoietic cell lineage_Homo sapiens_hsa046400.58177426
84Salivary secretion_Homo sapiens_hsa049700.56120560
85Pyrimidine metabolism_Homo sapiens_hsa002400.54617861
86Glycerolipid metabolism_Homo sapiens_hsa005610.54465783
87Mineral absorption_Homo sapiens_hsa049780.54134069
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46517745
89Calcium signaling pathway_Homo sapiens_hsa040200.45714402
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45294538
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45231124
92Steroid biosynthesis_Homo sapiens_hsa001000.44232827
93Antigen processing and presentation_Homo sapiens_hsa046120.44205568
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.43675498
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42926005
96Non-homologous end-joining_Homo sapiens_hsa034500.39121484
97Fatty acid degradation_Homo sapiens_hsa000710.37148199
98Nucleotide excision repair_Homo sapiens_hsa034200.32340190
99Histidine metabolism_Homo sapiens_hsa003400.29938066
100Dopaminergic synapse_Homo sapiens_hsa047280.28851353

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