RPL17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.55972471
2* viral transcription (GO:0019083)7.33856232
3* translational termination (GO:0006415)7.10206223
4* translational elongation (GO:0006414)6.22226694
5ribosomal small subunit biogenesis (GO:0042274)6.15195527
6maturation of SSU-rRNA (GO:0030490)5.99291888
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.88450227
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.79532395
9* protein targeting to ER (GO:0045047)5.74924271
10* cotranslational protein targeting to membrane (GO:0006613)5.71976928
11* translational initiation (GO:0006413)5.56774057
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.49905151
13ATP synthesis coupled proton transport (GO:0015986)5.49905151
14* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.49436509
15* viral life cycle (GO:0019058)5.46851797
16* cellular protein complex disassembly (GO:0043624)5.46578359
17* protein localization to endoplasmic reticulum (GO:0070972)5.32132120
18ribosomal large subunit biogenesis (GO:0042273)5.20870492
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06133825
20* protein complex disassembly (GO:0043241)4.91610493
21* macromolecular complex disassembly (GO:0032984)4.58487860
22formation of translation preinitiation complex (GO:0001731)4.36598041
23* protein targeting (GO:0006605)4.31465819
24* nuclear-transcribed mRNA catabolic process (GO:0000956)4.26892376
25DNA unwinding involved in DNA replication (GO:0006268)4.10856960
26* mRNA catabolic process (GO:0006402)4.05538471
27ribonucleoprotein complex biogenesis (GO:0022613)4.03320422
28* protein localization to membrane (GO:0072657)3.89442758
29* RNA catabolic process (GO:0006401)3.89109172
30* protein targeting to membrane (GO:0006612)3.80055588
31chaperone-mediated protein transport (GO:0072321)3.70069502
32folic acid-containing compound biosynthetic process (GO:0009396)3.67494023
33* translation (GO:0006412)3.66139483
34DNA strand elongation involved in DNA replication (GO:0006271)3.51910507
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.50405522
36protein localization to kinetochore (GO:0034501)3.46258122
37DNA strand elongation (GO:0022616)3.32067153
38telomere maintenance via semi-conservative replication (GO:0032201)3.25760261
39mitotic nuclear envelope disassembly (GO:0007077)3.24887800
40rRNA processing (GO:0006364)3.21837477
41negative regulation of RNA splicing (GO:0033119)3.21337029
42* protein localization to organelle (GO:0033365)3.19493834
43ncRNA 3-end processing (GO:0043628)3.18841019
44nuclear pore organization (GO:0006999)3.18284243
45respiratory electron transport chain (GO:0022904)3.15212466
46DNA replication initiation (GO:0006270)3.13843810
47rRNA metabolic process (GO:0016072)3.11280737
48* cellular component disassembly (GO:0022411)3.11111235
49electron transport chain (GO:0022900)3.10982051
50IMP biosynthetic process (GO:0006188)3.06754521
51nuclear pore complex assembly (GO:0051292)3.02814831
52membrane disassembly (GO:0030397)3.01036750
53nuclear envelope disassembly (GO:0051081)3.01036750
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99603510
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99603510
56protein localization to chromosome, centromeric region (GO:0071459)2.99054056
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96307967
58ATP biosynthetic process (GO:0006754)2.94053247
59ribosome assembly (GO:0042255)2.91172957
60telomere maintenance via recombination (GO:0000722)2.90196882
61mitotic chromosome condensation (GO:0007076)2.88524638
62mitotic recombination (GO:0006312)2.85857549
63ribosome biogenesis (GO:0042254)2.85765717
64nucleobase biosynthetic process (GO:0046112)2.83480543
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83203626
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83188628
67DNA duplex unwinding (GO:0032508)2.82675175
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82157282
69IMP metabolic process (GO:0046040)2.81155781
70DNA geometric change (GO:0032392)2.80611855
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78579531
72heterochromatin organization (GO:0070828)2.77997179
73mitotic metaphase plate congression (GO:0007080)2.77882147
74ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74931836
75DNA replication-dependent nucleosome organization (GO:0034723)2.74827335
76DNA replication-dependent nucleosome assembly (GO:0006335)2.74827335
77DNA replication checkpoint (GO:0000076)2.72092348
78protein neddylation (GO:0045116)2.71476242
79telomere maintenance via telomere lengthening (GO:0010833)2.70556959
80antigen processing and presentation of endogenous antigen (GO:0019883)2.70359443
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.67826666
82NADH dehydrogenase complex assembly (GO:0010257)2.67826666
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67826666
84regulation of histone H3-K9 methylation (GO:0051570)2.67174041
85negative regulation of histone methylation (GO:0031061)2.64025117
86cellular component biogenesis (GO:0044085)2.62799656
87regulation of translational fidelity (GO:0006450)2.61683364
88RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61210866
89mRNA splicing, via spliceosome (GO:0000398)2.61210866
90ncRNA processing (GO:0034470)2.60925876
91regulation of spindle organization (GO:0090224)2.60795801
92negative regulation of translational initiation (GO:0045947)2.60707993
93RNA splicing, via transesterification reactions (GO:0000375)2.60618438
94oxidative phosphorylation (GO:0006119)2.59826159
95chromatin remodeling at centromere (GO:0031055)2.59311072
96dosage compensation (GO:0007549)2.56034540
97DNA deamination (GO:0045006)2.55872649
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.54586260
99pyrimidine nucleotide catabolic process (GO:0006244)2.54141936
100spliceosomal snRNP assembly (GO:0000387)2.53354137
101UTP biosynthetic process (GO:0006228)2.53189488
102CENP-A containing nucleosome assembly (GO:0034080)2.52755160
103sister chromatid segregation (GO:0000819)2.51482548
104protein complex biogenesis (GO:0070271)2.51401225
105purine nucleobase biosynthetic process (GO:0009113)2.50833633
106DNA replication-independent nucleosome organization (GO:0034724)2.50737251
107DNA replication-independent nucleosome assembly (GO:0006336)2.50737251
108metaphase plate congression (GO:0051310)2.49283005
109spliceosomal complex assembly (GO:0000245)2.48869174
110mitochondrial respiratory chain complex assembly (GO:0033108)2.47970647
111chromatin assembly or disassembly (GO:0006333)2.47960535
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.47859375
113* establishment of protein localization to membrane (GO:0090150)2.47041047
114mitotic sister chromatid segregation (GO:0000070)2.46275268
115L-serine metabolic process (GO:0006563)2.45348077
116GTP biosynthetic process (GO:0006183)2.44486727
117myeloid cell homeostasis (GO:0002262)2.43247765
118viral mRNA export from host cell nucleus (GO:0046784)2.43235057
1193-UTR-mediated mRNA stabilization (GO:0070935)2.43120706
120regulation of protein heterodimerization activity (GO:0043497)2.42972434
121* establishment of protein localization to organelle (GO:0072594)2.42291999
122T cell apoptotic process (GO:0070231)2.42147456
123regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42070494
124regulation of mitotic spindle organization (GO:0060236)2.40159159
125termination of RNA polymerase II transcription (GO:0006369)2.39598643
126chromatin assembly (GO:0031497)2.39411444
127ribonucleoprotein complex assembly (GO:0022618)2.39336028
128translesion synthesis (GO:0019985)2.39114865
129negative regulation of mRNA processing (GO:0050686)2.38407835
130nuclear envelope organization (GO:0006998)2.38179471
131ribonucleoprotein complex subunit organization (GO:0071826)2.37782161
132* gene expression (GO:0010467)2.37773070
133establishment of integrated proviral latency (GO:0075713)2.37737405
134regulation of mitochondrial translation (GO:0070129)2.35414962
135pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.34564415
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.34523911
137inner mitochondrial membrane organization (GO:0007007)2.34350502
138ncRNA metabolic process (GO:0034660)2.33211567
139nucleoside triphosphate biosynthetic process (GO:0009142)2.31986720
140pattern specification involved in kidney development (GO:0061004)2.31492629
141UTP metabolic process (GO:0046051)2.30202804
142pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.29715675
143tongue development (GO:0043586)2.29659794
144kinetochore organization (GO:0051383)2.29428351
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.29308804
146hypothalamus development (GO:0021854)2.28675963
147CTP metabolic process (GO:0046036)2.27325697
148CTP biosynthetic process (GO:0006241)2.27325697
149purine nucleoside monophosphate biosynthetic process (GO:0009127)2.26026599
150purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.26026599
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.25040696
152termination of RNA polymerase III transcription (GO:0006386)2.25040696
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24663167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.20487744
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.03306117
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67918815
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.59922379
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02650061
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99831273
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.91751096
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64298009
9MYC_22102868_ChIP-Seq_BL_Human2.63720696
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41040817
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32947832
12* XRN2_22483619_ChIP-Seq_HELA_Human2.29986982
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29420464
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.25053987
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.20318866
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.10915021
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02184841
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02037307
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00252754
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94830031
21VDR_23849224_ChIP-Seq_CD4+_Human1.91584494
22* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91080302
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88981371
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82521806
25VDR_21846776_ChIP-Seq_THP-1_Human1.80055059
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76261084
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73741146
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72435160
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.72397035
30FOXP3_21729870_ChIP-Seq_TREG_Human1.72260724
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71918952
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71583292
33MYC_18940864_ChIP-ChIP_HL60_Human1.70631811
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70225360
35* TTF2_22483619_ChIP-Seq_HELA_Human1.70101027
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.69782946
37DCP1A_22483619_ChIP-Seq_HELA_Human1.69629514
38AR_21909140_ChIP-Seq_LNCAP_Human1.67944690
39CIITA_25753668_ChIP-Seq_RAJI_Human1.66882213
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63696717
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59470709
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59364326
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58490747
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56271326
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53154356
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52767696
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52743416
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50717793
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.49893320
50ELK1_19687146_ChIP-ChIP_HELA_Human1.47822608
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47128179
52GABP_19822575_ChIP-Seq_HepG2_Human1.47083040
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45937705
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42629369
55KDM5A_27292631_Chip-Seq_BREAST_Human1.41973417
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40372823
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39949087
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.37307807
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34744367
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34303069
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33410273
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32530567
63MAF_26560356_Chip-Seq_TH1_Human1.32055445
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29581316
65* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29145025
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27890107
67UTX_26944678_Chip-Seq_JUKART_Human1.27428364
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25615388
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24765238
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24186470
71SPI1_23547873_ChIP-Seq_NB4_Human1.23606600
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21590486
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18715485
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18562260
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17555000
76TFEB_21752829_ChIP-Seq_HELA_Human1.17519938
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16224926
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.15979090
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15723340
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15369923
81MYB_26560356_Chip-Seq_TH2_Human1.15178550
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14921799
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13403311
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13378202
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12539516
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12485149
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12399952
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12035161
89TCF7_22412390_ChIP-Seq_EML_Mouse1.11663036
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.10936049
91MYB_26560356_Chip-Seq_TH1_Human1.09944394
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09758630
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09640859
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.08164236
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07831041
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.06076695
97MAF_26560356_Chip-Seq_TH2_Human1.04557266
98IRF1_19129219_ChIP-ChIP_H3396_Human1.03685436
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03590676
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02387618
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.02011257
102* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01653293
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.00301488
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99724268
105* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99258619
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99211939
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98775687
108STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97881236
109VDR_24763502_ChIP-Seq_THP-1_Human0.97619218
110* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97070720
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94739653
112* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94665807
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.94608873
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94392917
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92976407
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91521934
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91049148
118* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90519289
119* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90162892
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.89972243
121CHD1_26751641_Chip-Seq_LNCaP_Human0.88837116
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87599977
123ATF3_27146783_Chip-Seq_COLON_Human0.87494182
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87486137
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.87082623
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86776708
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86240301
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86240301
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86240301
130* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85191841
131SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83296646
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82834236
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.81292907
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80870728
135POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.78789627
136* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76600187
137TET1_21451524_ChIP-Seq_MESCs_Mouse0.76061784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.22965808
2MP0003693_abnormal_embryo_hatching3.79096197
3MP0004957_abnormal_blastocyst_morpholog3.37253897
4MP0003136_yellow_coat_color2.88940625
5MP0010094_abnormal_chromosome_stability2.86040577
6MP0000566_synostosis2.85486179
7MP0003077_abnormal_cell_cycle2.83284853
8MP0003111_abnormal_nucleus_morphology2.81191779
9MP0010352_gastrointestinal_tract_polyps2.76581034
10MP0002938_white_spotting2.64461920
11MP0002396_abnormal_hematopoietic_system2.51753553
12MP0002163_abnormal_gland_morphology2.14800926
13MP0003763_abnormal_thymus_physiology2.12440590
14MP0004808_abnormal_hematopoietic_stem2.02153666
15MP0000490_abnormal_crypts_of1.96763817
16MP0008057_abnormal_DNA_replication1.95365640
17MP0008007_abnormal_cellular_replicative1.93972008
18MP0000049_abnormal_middle_ear1.85264335
19MP0001730_embryonic_growth_arrest1.83400693
20MP0003705_abnormal_hypodermis_morpholog1.81757344
21MP0000350_abnormal_cell_proliferation1.81682488
22MP0009333_abnormal_splenocyte_physiolog1.76433656
23MP0010307_abnormal_tumor_latency1.75161155
24MP0008058_abnormal_DNA_repair1.73516147
25MP0003300_gastrointestinal_ulcer1.73405442
26MP0001286_abnormal_eye_development1.69903071
27MP0003123_paternal_imprinting1.68824588
28MP0002697_abnormal_eye_size1.67950929
29MP0005076_abnormal_cell_differentiation1.66882381
30MP0000685_abnormal_immune_system1.63309128
31MP0002398_abnormal_bone_marrow1.63076317
32MP0006054_spinal_hemorrhage1.59616303
33MP0008932_abnormal_embryonic_tissue1.58529193
34MP0002166_altered_tumor_susceptibility1.57329251
35MP0002160_abnormal_reproductive_system1.56844580
36MP0000703_abnormal_thymus_morphology1.56710747
37MP0008789_abnormal_olfactory_epithelium1.55333039
38MP0010234_abnormal_vibrissa_follicle1.55295292
39MP0001835_abnormal_antigen_presentation1.54519380
40MP0009379_abnormal_foot_pigmentation1.54054171
41MP0001800_abnormal_humoral_immune1.51275326
42MP0003937_abnormal_limbs/digits/tail_de1.48042317
43MP0002722_abnormal_immune_system1.46981751
44MP0005397_hematopoietic_system_phenotyp1.45499310
45MP0001545_abnormal_hematopoietic_system1.45499310
46MP0002019_abnormal_tumor_incidence1.44650308
47MP0000631_abnormal_neuroendocrine_gland1.38333898
48MP0001697_abnormal_embryo_size1.37633100
49MP0000689_abnormal_spleen_morphology1.37445801
50MP0008995_early_reproductive_senescence1.36324281
51MP0003567_abnormal_fetal_cardiomyocyte1.35371628
52MP0005380_embryogenesis_phenotype1.35027108
53MP0001672_abnormal_embryogenesis/_devel1.35027108
54MP0009278_abnormal_bone_marrow1.34258443
55MP0003566_abnormal_cell_adhesion1.33418962
56MP0002080_prenatal_lethality1.32777596
57MP0005394_taste/olfaction_phenotype1.32586833
58MP0005499_abnormal_olfactory_system1.32586833
59MP0004197_abnormal_fetal_growth/weight/1.32239335
60MP0010155_abnormal_intestine_physiology1.32072369
61MP0002086_abnormal_extraembryonic_tissu1.31780912
62MP0003890_abnormal_embryonic-extraembry1.31108872
63MP0003984_embryonic_growth_retardation1.30478499
64MP0002088_abnormal_embryonic_growth/wei1.29477442
65MP0002452_abnormal_antigen_presenting1.28542358
66MP0000858_altered_metastatic_potential1.27736174
67MP0005023_abnormal_wound_healing1.27420765
68MP0001873_stomach_inflammation1.26862448
69MP0002006_tumorigenesis1.26375156
70MP0000716_abnormal_immune_system1.26342267
71MP0002420_abnormal_adaptive_immunity1.25655608
72MP0002429_abnormal_blood_cell1.25644661
73MP0003938_abnormal_ear_development1.24438157
74MP0002249_abnormal_larynx_morphology1.24214235
75MP0002233_abnormal_nose_morphology1.23654444
76MP0001819_abnormal_immune_cell1.23514488
77MP0003942_abnormal_urinary_system1.22914938
78MP0002095_abnormal_skin_pigmentation1.22057644
79MP0000313_abnormal_cell_death1.20781359
80MP0003303_peritoneal_inflammation1.18315657
81MP0002084_abnormal_developmental_patter1.17958792
82MP0005671_abnormal_response_to1.16066017
83MP0002085_abnormal_embryonic_tissue1.14966774
84MP0002405_respiratory_system_inflammati1.13123520
85MP0002638_abnormal_pupillary_reflex1.12959147
86MP0002092_abnormal_eye_morphology1.12704507
87MP0003755_abnormal_palate_morphology1.12650258
88MP0003786_premature_aging1.11811010
89MP0009250_abnormal_appendicular_skeleto1.11487616
90MP0002723_abnormal_immune_serum1.10023946
91MP0000762_abnormal_tongue_morphology1.07423967
92MP0003436_decreased_susceptibility_to1.06243896
93MP0002653_abnormal_ependyma_morphology1.05416383
94MP0001346_abnormal_lacrimal_gland1.05165690
95MP0005387_immune_system_phenotype1.04669022
96MP0001790_abnormal_immune_system1.04669022
97MP0000537_abnormal_urethra_morphology1.03234114
98MP0000465_gastrointestinal_hemorrhage1.03006047
99MP0005000_abnormal_immune_tolerance1.01910399
100MP0004947_skin_inflammation1.01199759
101MP0005408_hypopigmentation0.99300288
102MP0002932_abnormal_joint_morphology0.99273284
103MP0000372_irregular_coat_pigmentation0.97779717
104MP0002210_abnormal_sex_determination0.95873847
105MP0003186_abnormal_redox_activity0.95858050
106MP0009053_abnormal_anal_canal0.95605715
107MP0000477_abnormal_intestine_morphology0.95293657
108MP0003866_abnormal_defecation0.95185504
109MP0005377_hearing/vestibular/ear_phenot0.92930803
110MP0003878_abnormal_ear_physiology0.92930803
111MP0006072_abnormal_retinal_apoptosis0.92896947
112MP0001853_heart_inflammation0.92559282
113MP0005025_abnormal_response_to0.92446070
114MP0000733_abnormal_muscle_development0.92098199
115MP0003861_abnormal_nervous_system0.91472174
116MP0005389_reproductive_system_phenotype0.91305003
117MP0002116_abnormal_craniofacial_bone0.91021053
118MP0002877_abnormal_melanocyte_morpholog0.90995730
119MP0003448_altered_tumor_morphology0.90670192
120MP0001849_ear_inflammation0.88752685
121MP0000678_abnormal_parathyroid_gland0.88631720
122MP0003011_delayed_dark_adaptation0.87812461
123MP0003385_abnormal_body_wall0.86277240
124MP0005379_endocrine/exocrine_gland_phen0.86062436
125MP0003941_abnormal_skin_development0.85246504
126MP0000778_abnormal_nervous_system0.84680221
127MP0005501_abnormal_skin_physiology0.83093829
128MP0003121_genomic_imprinting0.82699227
129MP0003283_abnormal_digestive_organ0.82482131
130MP0001145_abnormal_male_reproductive0.82365266
131MP0001485_abnormal_pinna_reflex0.79946046
132MP0003453_abnormal_keratinocyte_physiol0.79821324
133MP0004133_heterotaxia0.79540379
134MP0010030_abnormal_orbit_morphology0.79196154
135MP0002234_abnormal_pharynx_morphology0.78734410
136MP0005391_vision/eye_phenotype0.78604045
137MP0004142_abnormal_muscle_tone0.78546623
138MP0001529_abnormal_vocalization0.78422912
139MP0001845_abnormal_inflammatory_respons0.76465700
140MP0005174_abnormal_tail_pigmentation0.75944557
141MP0009785_altered_susceptibility_to0.75875474
142MP0000026_abnormal_inner_ear0.75401236
143MP0002109_abnormal_limb_morphology0.74815167
144MP0002132_abnormal_respiratory_system0.74668693
145MP0001293_anophthalmia0.74567437
146MP0003122_maternal_imprinting0.72548581
147MP0001915_intracranial_hemorrhage0.71819321
148MP0005195_abnormal_posterior_eye0.71625875
149MP0003935_abnormal_craniofacial_develop0.71578550
150MP0000750_abnormal_muscle_regeneration0.71290182
151MP0004185_abnormal_adipocyte_glucose0.70243660
152MP0001340_abnormal_eyelid_morphology0.69720288
153MP0000653_abnormal_sex_gland0.69240970
154MP0001216_abnormal_epidermal_layer0.68617447
155MP0000428_abnormal_craniofacial_morphol0.68551726
156MP0005621_abnormal_cell_physiology0.68088796
157MP0005464_abnormal_platelet_physiology0.67612548
158MP0005503_abnormal_tendon_morphology0.66703148
159MP0000534_abnormal_ureter_morphology0.65539048
160MP0009672_abnormal_birth_weight0.64967762
161MP0002114_abnormal_axial_skeleton0.64517834
162MP0000432_abnormal_head_morphology0.63108024
163MP0005075_abnormal_melanosome_morpholog0.62722367
164MP0003315_abnormal_perineum_morphology0.62692647
165MP0000358_abnormal_cell_content/0.62556572
166MP0003119_abnormal_digestive_system0.62540811
167MP0005384_cellular_phenotype0.62188027
168MP0004147_increased_porphyrin_level0.62062925
169MP0002111_abnormal_tail_morphology0.62045871
170MP0002060_abnormal_skin_morphology0.60253647

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.03835334
2Abnormality of cells of the erythroid lineage (HP:0012130)5.91573239
3Abnormal number of erythroid precursors (HP:0012131)5.21901466
4Macrocytic anemia (HP:0001972)4.12776123
5Thrombocytosis (HP:0001894)4.06935503
6Pallor (HP:0000980)3.99898632
7Colon cancer (HP:0003003)3.65963832
8Septo-optic dysplasia (HP:0100842)3.48109248
9Partial duplication of thumb phalanx (HP:0009944)3.34787608
10Increased hepatocellular lipid droplets (HP:0006565)3.13814023
11Partial duplication of the phalanx of hand (HP:0009999)3.13361596
12Acute necrotizing encephalopathy (HP:0006965)3.08164670
13Abnormal hemoglobin (HP:0011902)2.96998605
14Rib fusion (HP:0000902)2.89196666
15Lipid accumulation in hepatocytes (HP:0006561)2.83776118
16Abnormal mitochondria in muscle tissue (HP:0008316)2.81603579
17Multiple enchondromatosis (HP:0005701)2.80237502
18IgM deficiency (HP:0002850)2.79464401
19Oral leukoplakia (HP:0002745)2.78879085
20Mitochondrial inheritance (HP:0001427)2.78336295
21Selective tooth agenesis (HP:0001592)2.73152992
22Triphalangeal thumb (HP:0001199)2.72088179
23Acute encephalopathy (HP:0006846)2.71138794
24Basal cell carcinoma (HP:0002671)2.69865102
25Trismus (HP:0000211)2.69088965
26Duplication of thumb phalanx (HP:0009942)2.67465232
27Aplastic anemia (HP:0001915)2.63188114
28Hypoplasia of the radius (HP:0002984)2.52310711
29T lymphocytopenia (HP:0005403)2.48104065
30Rectal prolapse (HP:0002035)2.47086149
3111 pairs of ribs (HP:0000878)2.40812486
32Recurrent bronchitis (HP:0002837)2.40727002
33Ependymoma (HP:0002888)2.40530606
34Horseshoe kidney (HP:0000085)2.39486743
35Abnormality of reticulocytes (HP:0004312)2.37692663
36Abnormality of the parietal bone (HP:0002696)2.37357514
37Absent thumb (HP:0009777)2.37236550
38Increased CSF lactate (HP:0002490)2.37071304
39Abnormality of T cells (HP:0002843)2.35990331
40Biliary tract neoplasm (HP:0100574)2.32117398
41Chromsome breakage (HP:0040012)2.30125332
42Hepatocellular necrosis (HP:0001404)2.29601487
43Recurrent viral infections (HP:0004429)2.29220053
44Anophthalmia (HP:0000528)2.28948249
45Birth length less than 3rd percentile (HP:0003561)2.28583903
46Increased density of long bones (HP:0006392)2.28580900
47Abnormality of T cell number (HP:0011839)2.28427338
48Progressive macrocephaly (HP:0004481)2.24737617
49Maternal diabetes (HP:0009800)2.23791763
50Neoplasm of the pancreas (HP:0002894)2.21254500
51Ectopic kidney (HP:0000086)2.21152768
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20316743
53Abnormal number of incisors (HP:0011064)2.16365469
54Abnormality of DNA repair (HP:0003254)2.15187216
55Poikiloderma (HP:0001029)2.14760514
56Increased intramyocellular lipid droplets (HP:0012240)2.13153853
57Renal Fanconi syndrome (HP:0001994)2.11810107
58Myelodysplasia (HP:0002863)2.10103651
59Absent septum pellucidum (HP:0001331)2.09947442
60Abnormality of T cell physiology (HP:0011840)2.08559756
61Missing ribs (HP:0000921)2.07814124
62Amaurosis fugax (HP:0100576)2.07307101
63Chronic otitis media (HP:0000389)2.06793624
64Lymphoma (HP:0002665)2.06629181
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04805576
66Respiratory difficulties (HP:0002880)2.03905912
67Abnormality of cochlea (HP:0000375)2.03803645
68Papilloma (HP:0012740)2.01733480
69Verrucae (HP:0200043)2.01733480
70Diastasis recti (HP:0001540)2.01054895
71Abnormality of the fingertips (HP:0001211)2.00994533
72Proximal placement of thumb (HP:0009623)2.00629093
73Deviation of the thumb (HP:0009603)1.98557640
74Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97920102
75Migraine (HP:0002076)1.96866073
76Rhabdomyosarcoma (HP:0002859)1.96176471
77Medulloblastoma (HP:0002885)1.93810145
78Hepatic necrosis (HP:0002605)1.92896953
79Bicuspid aortic valve (HP:0001647)1.92812555
80Cerebral edema (HP:0002181)1.92520291
81Pustule (HP:0200039)1.92203578
82Microretrognathia (HP:0000308)1.91241798
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.89778911
84Atresia of the external auditory canal (HP:0000413)1.89467877
85Cellulitis (HP:0100658)1.88345242
86Abnormality of cells of the lymphoid lineage (HP:0012140)1.88055948
87Breast hypoplasia (HP:0003187)1.87953467
88Rough bone trabeculation (HP:0100670)1.87466902
89Congenital, generalized hypertrichosis (HP:0004540)1.87452969
90Pancreatic fibrosis (HP:0100732)1.85590080
91Abnormality of the anterior horn cell (HP:0006802)1.85354522
92Degeneration of anterior horn cells (HP:0002398)1.85354522
93Ankle contracture (HP:0006466)1.84461452
94Gastrointestinal inflammation (HP:0004386)1.84090511
95Squamous cell carcinoma (HP:0002860)1.83297677
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.83199175
97Hypoplasia of the pons (HP:0012110)1.83170524
98Neoplasm of the colon (HP:0100273)1.82932816
99Adenoma sebaceum (HP:0009720)1.82904276
100Angiofibromas (HP:0010615)1.82904276
101Lymphopenia (HP:0001888)1.82518321
102Thick lower lip vermilion (HP:0000179)1.82416588
103Abnormality of the 4th metacarpal (HP:0010012)1.81170871
104Nasal polyposis (HP:0100582)1.80773755
105Abnormality of the septum pellucidum (HP:0007375)1.80171082
106Agnosia (HP:0010524)1.79236772
107Protrusio acetabuli (HP:0003179)1.79205001
108High pitched voice (HP:0001620)1.79098041
109Gastrointestinal carcinoma (HP:0002672)1.78789041
110Malignant gastrointestinal tract tumors (HP:0006749)1.78789041
111Prominent nose (HP:0000448)1.78626636
112Increased nuchal translucency (HP:0010880)1.77444429
113Panhypogammaglobulinemia (HP:0003139)1.76882316
114Depressed nasal ridge (HP:0000457)1.76749860
115Abnormality of the renal collecting system (HP:0004742)1.74689599
116Hypoplastic pelvis (HP:0008839)1.74229774
117Forearm undergrowth (HP:0009821)1.74043265
118Abnormality of the pons (HP:0007361)1.73902335
119Cellular immunodeficiency (HP:0005374)1.73331194
120Carpal bone hypoplasia (HP:0001498)1.73232508
121Neoplasm of the rectum (HP:0100743)1.73103900
122Increased muscle lipid content (HP:0009058)1.72878096
123Glossoptosis (HP:0000162)1.72435313
124Patellar aplasia (HP:0006443)1.72295463
125Blepharitis (HP:0000498)1.70985760
126Abnormality of the diencephalon (HP:0010662)1.69857439
127Short nose (HP:0003196)1.69277908
128Inflammation of the large intestine (HP:0002037)1.69180069
129Abnormality of B cell number (HP:0010975)1.68761935
130B lymphocytopenia (HP:0010976)1.68761935
131Hypoplasia of the ulna (HP:0003022)1.68460321
132Recurrent fungal infections (HP:0002841)1.68306824
133Hyperacusis (HP:0010780)1.67959826
134Elevated erythrocyte sedimentation rate (HP:0003565)1.67792675
135Abnormality of the calcaneus (HP:0008364)1.67766919
136Leukodystrophy (HP:0002415)1.66585761
137Esophageal atresia (HP:0002032)1.66569890
138Coronal craniosynostosis (HP:0004440)1.66201325
139Aplasia/Hypoplasia of the patella (HP:0006498)1.65638347
140Progressive muscle weakness (HP:0003323)1.65474321
141Hematochezia (HP:0002573)1.65255437
142Increased serum lactate (HP:0002151)1.65184060
143Microvesicular hepatic steatosis (HP:0001414)1.65124654
144IgA deficiency (HP:0002720)1.64861512
145Morphological abnormality of the inner ear (HP:0011390)1.64395663
146Abnormality of the preputium (HP:0100587)1.63985935
147Entropion (HP:0000621)1.63225353
148Abnormality of the nasal mucosa (HP:0000433)1.62929382
149Bilateral microphthalmos (HP:0007633)1.62793990
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.62046114
151Neoplasm of the small intestine (HP:0100833)1.61759082
152Aplasia/Hypoplasia of the thymus (HP:0010515)1.61713622
153Skin tags (HP:0010609)1.61610298
154Tracheoesophageal fistula (HP:0002575)1.61022305
155Overlapping toe (HP:0001845)1.60777061
156Premature graying of hair (HP:0002216)1.60657057
157Stenosis of the external auditory canal (HP:0000402)1.59818084
158Petechiae (HP:0000967)1.59300803
159Asplenia (HP:0001746)1.59200189
160Meckel diverticulum (HP:0002245)1.59141477
161Abnormality of chromosome stability (HP:0003220)1.59099731
162Woolly hair (HP:0002224)1.58708995
163Duplicated collecting system (HP:0000081)1.58074417
164Nasolacrimal duct obstruction (HP:0000579)1.57692259
1653-Methylglutaconic aciduria (HP:0003535)1.56444448
166Abnormality of the ileum (HP:0001549)1.56282250
167Lactic acidosis (HP:0003128)1.55889019
168Short thumb (HP:0009778)1.51571770
169Partial agenesis of the corpus callosum (HP:0001338)1.50208096
170Holoprosencephaly (HP:0001360)1.49670317
171Exertional dyspnea (HP:0002875)1.49657885
172Abnormality of the phalanges of the 2nd finger (HP:0009541)1.48917988
173Exercise intolerance (HP:0003546)1.48419848
174Abnormality of the lacrimal duct (HP:0011481)1.47853239
175Facial cleft (HP:0002006)1.47315406
176Anomalous pulmonary venous return (HP:0010772)1.46678196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.62638839
2VRK23.60411758
3CDK193.57537354
4STK163.49246964
5NME23.16919352
6PKN22.93960417
7CDC72.66486558
8MAP4K12.65207195
9ZAK2.64392782
10WEE12.41603016
11RPS6KB22.40469647
12NEK22.36649671
13LRRK22.28886360
14MAP3K102.18341125
15TRIB32.14249156
16TLK12.06476269
17PASK2.03620996
18BUB12.03594412
19TAF12.02870611
20EIF2AK11.94927721
21RPS6KA41.85009890
22STK101.84638692
23CDK121.79955753
24TGFBR11.69632714
25WNK41.68335699
26NME11.62316429
27FLT31.61724795
28SCYL21.55767839
29TYRO31.55678212
30EPHB21.51564341
31TSSK61.48163780
32DYRK21.45194879
33CDK41.39796069
34AURKB1.37360932
35DAPK31.35572725
36GRK61.35570862
37MAP3K81.35333484
38SRPK11.34260604
39ZAP701.26235156
40NEK11.25645584
41TTK1.24571030
42PAK41.22439413
43CDK71.21878996
44JAK31.20989787
45BRAF1.19944078
46TESK21.18880670
47PIM11.18798401
48DYRK31.18093502
49MAP2K31.16712598
50SMG11.16569101
51CDK81.16276306
52ACVR1B1.14417968
53CDK61.11974086
54EPHA21.11546037
55BTK1.11531226
56ALK1.10962193
57PLK11.09621971
58ATR1.07946055
59BRSK21.06323031
60RPS6KA61.02376990
61MKNK11.01711924
62EIF2AK30.98178024
63ILK0.97964542
64RPS6KL10.97931759
65STK40.95474434
66STK240.94893260
67NUAK10.92094358
68TYK20.91845961
69TTN0.91010488
70PTK60.87028766
71ERN10.86559901
72MST40.82917712
73CHEK10.82699602
74PBK0.81967890
75CAMK1D0.81678785
76NEK90.80190464
77TEC0.80046233
78DYRK1B0.79483890
79MAPK150.74700033
80BLK0.73557978
81PIK3CA0.72671027
82MAPKAPK30.71698850
83PIM20.69292873
84CSF1R0.67589688
85ITK0.67442455
86VRK10.67196703
87BCKDK0.67035606
88WNK10.66741337
89FGFR40.65268063
90PNCK0.63813828
91CSNK1E0.62774462
92BRD40.62445966
93BRSK10.62190781
94PAK20.62159795
95NLK0.61239509
96MAP3K110.60499771
97IKBKB0.59433625
98PDK20.58548651
99STK30.57567580
100TBK10.57534400
101CSNK2A20.57506474
102CDK20.57428434
103MELK0.56130336
104ATM0.54639911
105MAP3K30.54226160
106KIT0.54075345
107TIE10.53691690
108MKNK20.53646270
109MTOR0.53632408
110CHEK20.53439500
111LCK0.52397527
112TESK10.52334330
113DMPK0.51750910
114MAP3K90.51699042
115CAMK1G0.51275303
116FGFR10.51079269
117CHUK0.49228639
118AURKA0.49228363
119FGFR20.48878580
120TXK0.48679659
121KDR0.48612201
122PLK30.47983970
123SYK0.46628725
124FGFR30.46279230
125CDK90.46153058
126CDK10.45049921
127TGFBR20.44548520
128RPS6KA50.44111404
129RPS6KB10.43564846
130BMX0.42595821
131CDK30.41740544
132PAK10.41485265
133AKT10.41207747
134MARK30.40300399
135PLK40.39744518
136AKT20.39199245
137PDGFRA0.38852522
138IKBKE0.38400030
139CSNK2A10.38010486
140ADRBK20.37599986
141BMPR1B0.37421426
142ABL20.34941816
143RPS6KA10.34144490
144RPS6KC10.34108523
145CDK11A0.33745969
146PRKDC0.31585701
147ICK0.30975876
148STK110.30392684
149MAP2K40.29695533
150MAP2K20.29309739
151GRK10.27427327
152INSRR0.26469763
153SGK2230.23783489
154SGK4940.23783489

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.57224716
2DNA replication_Homo sapiens_hsa030303.90874167
3Oxidative phosphorylation_Homo sapiens_hsa001903.46314327
4Mismatch repair_Homo sapiens_hsa034303.32629506
5Parkinsons disease_Homo sapiens_hsa050123.08175946
6Spliceosome_Homo sapiens_hsa030402.99406453
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79110645
8RNA transport_Homo sapiens_hsa030132.60309250
9Huntingtons disease_Homo sapiens_hsa050162.43292901
10One carbon pool by folate_Homo sapiens_hsa006702.43127384
11Base excision repair_Homo sapiens_hsa034102.38041631
12Nucleotide excision repair_Homo sapiens_hsa034202.14815385
13Homologous recombination_Homo sapiens_hsa034402.11297834
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05475117
15Alzheimers disease_Homo sapiens_hsa050102.05280405
16RNA polymerase_Homo sapiens_hsa030202.05041763
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03418343
18Proteasome_Homo sapiens_hsa030502.02643647
19Cell cycle_Homo sapiens_hsa041102.01245089
20Antigen processing and presentation_Homo sapiens_hsa046121.76949299
21Cardiac muscle contraction_Homo sapiens_hsa042601.74099893
22Pyrimidine metabolism_Homo sapiens_hsa002401.69327426
23Primary immunodeficiency_Homo sapiens_hsa053401.69139357
24Non-homologous end-joining_Homo sapiens_hsa034501.62223023
25mRNA surveillance pathway_Homo sapiens_hsa030151.54622487
26p53 signaling pathway_Homo sapiens_hsa041151.49054967
27RNA degradation_Homo sapiens_hsa030181.44838264
28Herpes simplex infection_Homo sapiens_hsa051681.32303340
29Systemic lupus erythematosus_Homo sapiens_hsa053221.29369397
30Fanconi anemia pathway_Homo sapiens_hsa034601.28633441
31Epstein-Barr virus infection_Homo sapiens_hsa051691.23552214
32Viral carcinogenesis_Homo sapiens_hsa052031.18756521
33Hedgehog signaling pathway_Homo sapiens_hsa043401.11064843
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10743075
35Small cell lung cancer_Homo sapiens_hsa052221.09054913
36HTLV-I infection_Homo sapiens_hsa051661.06649174
37Chronic myeloid leukemia_Homo sapiens_hsa052201.05734394
38B cell receptor signaling pathway_Homo sapiens_hsa046621.01254313
39Measles_Homo sapiens_hsa051621.00390028
40Thyroid cancer_Homo sapiens_hsa052160.99860572
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.99327855
42Legionellosis_Homo sapiens_hsa051340.94443500
43Acute myeloid leukemia_Homo sapiens_hsa052210.93440662
44Basal transcription factors_Homo sapiens_hsa030220.92569384
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90336842
46Apoptosis_Homo sapiens_hsa042100.86584986
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.86514049
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85298487
49Sulfur relay system_Homo sapiens_hsa041220.85014929
50Hematopoietic cell lineage_Homo sapiens_hsa046400.83427246
51Leishmaniasis_Homo sapiens_hsa051400.81711020
52MicroRNAs in cancer_Homo sapiens_hsa052060.81486336
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79550335
54Hepatitis B_Homo sapiens_hsa051610.79456332
55T cell receptor signaling pathway_Homo sapiens_hsa046600.78657842
56Pentose phosphate pathway_Homo sapiens_hsa000300.77036557
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.74403976
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73556591
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71911424
60Shigellosis_Homo sapiens_hsa051310.69981721
61Selenocompound metabolism_Homo sapiens_hsa004500.68880656
62Colorectal cancer_Homo sapiens_hsa052100.68518335
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67987818
64Notch signaling pathway_Homo sapiens_hsa043300.67950419
65Toxoplasmosis_Homo sapiens_hsa051450.67875979
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67431276
67Bladder cancer_Homo sapiens_hsa052190.65178923
68Influenza A_Homo sapiens_hsa051640.64837154
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64723429
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.64677682
71Wnt signaling pathway_Homo sapiens_hsa043100.62752030
72Purine metabolism_Homo sapiens_hsa002300.62704900
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62553947
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62291461
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.62287577
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59420898
77Non-small cell lung cancer_Homo sapiens_hsa052230.59246264
78Viral myocarditis_Homo sapiens_hsa054160.58307354
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58122240
80Pyruvate metabolism_Homo sapiens_hsa006200.57717709
81Osteoclast differentiation_Homo sapiens_hsa043800.57666222
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57535496
83HIF-1 signaling pathway_Homo sapiens_hsa040660.57508071
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57328820
85Pancreatic cancer_Homo sapiens_hsa052120.56309353
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55781738
87mTOR signaling pathway_Homo sapiens_hsa041500.54209577
88Proteoglycans in cancer_Homo sapiens_hsa052050.53229949
89Biosynthesis of amino acids_Homo sapiens_hsa012300.51721327
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51259818
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49560834
92Adherens junction_Homo sapiens_hsa045200.49146657
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.48606265
94Protein export_Homo sapiens_hsa030600.48524906
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48424114
96Metabolic pathways_Homo sapiens_hsa011000.48403750
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47969846
98Folate biosynthesis_Homo sapiens_hsa007900.47209463
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46481330
100N-Glycan biosynthesis_Homo sapiens_hsa005100.46223454
101Pathways in cancer_Homo sapiens_hsa052000.44557074
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44251295
103TGF-beta signaling pathway_Homo sapiens_hsa043500.43713776
104Prostate cancer_Homo sapiens_hsa052150.43236759
105Basal cell carcinoma_Homo sapiens_hsa052170.41040331
106Glutathione metabolism_Homo sapiens_hsa004800.39059036
107Platelet activation_Homo sapiens_hsa046110.38786235
108Hippo signaling pathway_Homo sapiens_hsa043900.38219716
109TNF signaling pathway_Homo sapiens_hsa046680.37171315
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36881069
111Endometrial cancer_Homo sapiens_hsa052130.36528314
112Oocyte meiosis_Homo sapiens_hsa041140.35806704
113Fat digestion and absorption_Homo sapiens_hsa049750.34760268
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.34728031
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.34532008
116Linoleic acid metabolism_Homo sapiens_hsa005910.34504930
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32871581
118Vitamin digestion and absorption_Homo sapiens_hsa049770.31237771
119Hepatitis C_Homo sapiens_hsa051600.30262842
120Alcoholism_Homo sapiens_hsa050340.29452774
121Carbon metabolism_Homo sapiens_hsa012000.28637751
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28355543
123Prolactin signaling pathway_Homo sapiens_hsa049170.28345207
124Melanoma_Homo sapiens_hsa052180.24427926
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22051606
126Melanogenesis_Homo sapiens_hsa049160.20962547
127Arachidonic acid metabolism_Homo sapiens_hsa005900.16632990
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.16576872
129Steroid biosynthesis_Homo sapiens_hsa001000.15378508
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13614308
131Peroxisome_Homo sapiens_hsa041460.10820892
132Propanoate metabolism_Homo sapiens_hsa006400.10714216
133Arginine and proline metabolism_Homo sapiens_hsa003300.09018176
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08499211
135Lysine degradation_Homo sapiens_hsa003100.05782063
136Nitrogen metabolism_Homo sapiens_hsa009100.05414104
137Asthma_Homo sapiens_hsa053100.05274131
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.02767908
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02476919
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.01863944
141Tyrosine metabolism_Homo sapiens_hsa003500.00070707
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0308233
143Ether lipid metabolism_Homo sapiens_hsa00565-0.0204541
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0113452

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