RPL13AP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.19979537
2ribosomal small subunit assembly (GO:0000028)8.25755505
3viral transcription (GO:0019083)7.98922785
4translational termination (GO:0006415)7.75193848
5translational elongation (GO:0006414)6.62916611
6cotranslational protein targeting to membrane (GO:0006613)6.16686303
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.11810605
8protein targeting to ER (GO:0045047)6.11274804
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.82980463
10ATP synthesis coupled proton transport (GO:0015986)5.82980463
11cellular protein complex disassembly (GO:0043624)5.82735679
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.80086921
13protein localization to endoplasmic reticulum (GO:0070972)5.77705018
14viral life cycle (GO:0019058)5.72266630
15maturation of SSU-rRNA (GO:0030490)5.69252950
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.64226302
17protein complex disassembly (GO:0043241)4.92552054
18translational initiation (GO:0006413)4.87052187
19macromolecular complex disassembly (GO:0032984)4.67357594
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.62888659
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.62888659
22NADH dehydrogenase complex assembly (GO:0010257)4.62888659
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.29187898
24ribonucleoprotein complex biogenesis (GO:0022613)4.28288802
25DNA deamination (GO:0045006)4.26463139
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22650290
27ribosomal large subunit biogenesis (GO:0042273)4.19473573
28chaperone-mediated protein transport (GO:0072321)4.18602191
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.17433283
30maternal behavior (GO:0042711)4.14098417
31protein targeting to membrane (GO:0006612)4.13639690
32translation (GO:0006412)4.08826274
33nuclear-transcribed mRNA catabolic process (GO:0000956)4.06405268
34cellular response to nicotine (GO:0071316)4.02097211
35cellular component biogenesis (GO:0044085)3.92658134
36respiratory electron transport chain (GO:0022904)3.91001023
37electron transport chain (GO:0022900)3.85291587
38mRNA catabolic process (GO:0006402)3.84385946
39pyrimidine nucleotide catabolic process (GO:0006244)3.80330724
40ATP biosynthetic process (GO:0006754)3.78857967
41positive T cell selection (GO:0043368)3.77476032
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.74594028
43positive regulation of cellular response to oxidative stress (GO:1900409)3.70446675
44positive regulation of response to oxidative stress (GO:1902884)3.70446675
45neurofilament cytoskeleton organization (GO:0060052)3.67243226
46parental behavior (GO:0060746)3.63857585
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63351508
48protein complex biogenesis (GO:0070271)3.62459987
49GTP biosynthetic process (GO:0006183)3.61091553
50positive thymic T cell selection (GO:0045059)3.58596817
51oxygen transport (GO:0015671)3.56587171
52RNA catabolic process (GO:0006401)3.42754417
53cardiovascular system development (GO:0072358)3.40699870
54superoxide anion generation (GO:0042554)3.39668564
55regulation of isotype switching to IgG isotypes (GO:0048302)3.39323248
56behavioral response to nicotine (GO:0035095)3.31467232
57mitochondrial respiratory chain complex assembly (GO:0033108)3.30505542
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29859980
59middle ear morphogenesis (GO:0042474)3.25449513
60hydrogen peroxide biosynthetic process (GO:0050665)3.22928775
61startle response (GO:0001964)3.21758503
62ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19986402
63UTP biosynthetic process (GO:0006228)3.15934846
64axonemal dynein complex assembly (GO:0070286)3.12435966
65negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.11409516
66autophagic vacuole fusion (GO:0000046)3.11118739
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08336815
68auditory receptor cell differentiation (GO:0042491)3.04006699
69protein-cofactor linkage (GO:0018065)2.99295449
70myoblast migration (GO:0051451)2.96272927
71reactive oxygen species biosynthetic process (GO:1903409)2.88377090
72hypothalamus development (GO:0021854)2.87722538
73regulation of B cell receptor signaling pathway (GO:0050855)2.86358615
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84530133
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84530133
76gas transport (GO:0015669)2.82785971
77L-fucose catabolic process (GO:0042355)2.80191809
78fucose catabolic process (GO:0019317)2.80191809
79L-fucose metabolic process (GO:0042354)2.80191809
80substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.79867075
81substrate-independent telencephalic tangential migration (GO:0021826)2.79867075
82rRNA processing (GO:0006364)2.78069408
83UTP metabolic process (GO:0046051)2.76433567
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75248979
85regulation of cellular respiration (GO:0043457)2.74767158
86rRNA metabolic process (GO:0016072)2.74450122
87establishment of protein localization to organelle (GO:0072594)2.74263937
88protein targeting (GO:0006605)2.73595791
89nucleoside triphosphate biosynthetic process (GO:0009142)2.73504100
90outer ear morphogenesis (GO:0042473)2.73385936
91phenylpropanoid metabolic process (GO:0009698)2.72734365
92guanosine-containing compound biosynthetic process (GO:1901070)2.72376550
93establishment of protein localization to membrane (GO:0090150)2.71815169
94regulation of cilium movement (GO:0003352)2.70793333
95ncRNA 3-end processing (GO:0043628)2.70434685
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69614039
97peptidyl-histidine modification (GO:0018202)2.67164499
98preassembly of GPI anchor in ER membrane (GO:0016254)2.64781460
99hydrogen ion transmembrane transport (GO:1902600)2.64580390
100ribosome biogenesis (GO:0042254)2.64008217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.11336916
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.36826258
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.20956083
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.50373879
5EZH2_22144423_ChIP-Seq_EOC_Human3.31008704
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04594163
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.88808597
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.88635748
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.85364871
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83504534
11IRF1_19129219_ChIP-ChIP_H3396_Human2.69187015
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48119247
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.39255728
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36260690
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27563691
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27451385
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20996164
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18932960
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16197956
20VDR_23849224_ChIP-Seq_CD4+_Human2.15977808
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.10103973
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.07678977
23VDR_22108803_ChIP-Seq_LS180_Human2.03301422
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00609131
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.94028036
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.86067996
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76414458
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.75959199
29FOXP3_21729870_ChIP-Seq_TREG_Human1.75613032
30* XRN2_22483619_ChIP-Seq_HELA_Human1.71905368
31VDR_21846776_ChIP-Seq_THP-1_Human1.68936496
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67694209
33GABP_19822575_ChIP-Seq_HepG2_Human1.66863115
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.63927136
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61913454
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58552146
37ZNF274_21170338_ChIP-Seq_K562_Hela1.51344225
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45087625
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41501421
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40365969
41MYC_18940864_ChIP-ChIP_HL60_Human1.37090314
42STAT1_20625510_ChIP-Seq_HELA_Human1.36390471
43TTF2_22483619_ChIP-Seq_HELA_Human1.36223041
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26017963
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25804874
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24069876
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23799927
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23141666
49SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21164421
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.20432884
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20360196
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20305853
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20025685
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20022530
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17809843
56ELK1_19687146_ChIP-ChIP_HELA_Human1.17511391
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17236799
58TP53_22573176_ChIP-Seq_HFKS_Human1.17179465
59NANOG_20526341_ChIP-Seq_ESCs_Human1.16866710
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15482351
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15362221
62IGF1R_20145208_ChIP-Seq_DFB_Human1.14028082
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10811031
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10811031
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10811031
66CTCF_26484167_Chip-Seq_Bcells_Mouse1.05434509
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04863634
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04205649
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04090020
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04081445
71RUNX_20019798_ChIP-Seq_JUKART_Human1.03914875
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01659852
73SPI1_20517297_ChIP-Seq_HL60_Human1.01397327
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00400873
75CTCF_20526341_ChIP-Seq_ESCs_Human0.98037956
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97548286
77BCL6_27268052_Chip-Seq_Bcells_Human0.97017490
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96780350
79MAF_26560356_Chip-Seq_TH2_Human0.95446566
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94950633
81FOXP1_21924763_ChIP-Seq_HESCs_Human0.94284821
82GATA3_21867929_ChIP-Seq_TH1_Mouse0.94043979
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94005790
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93615449
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.93438982
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93385711
87ERA_21632823_ChIP-Seq_H3396_Human0.92774140
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92708082
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91618601
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90837742
91UTX_26944678_Chip-Seq_JUKART_Human0.90463042
92MYC_19829295_ChIP-Seq_ESCs_Human0.89496292
93MYB_26560356_Chip-Seq_TH2_Human0.89197233
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88288593
95JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87922197
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87318624
97CIITA_25753668_ChIP-Seq_RAJI_Human0.86993629
98GATA3_26560356_Chip-Seq_TH2_Human0.85133071
99E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84265625
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83998585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.81245873
2MP0005377_hearing/vestibular/ear_phenot4.24828285
3MP0003878_abnormal_ear_physiology4.24828285
4MP0002163_abnormal_gland_morphology3.23441650
5MP0000569_abnormal_digit_pigmentation3.17142353
6MP0004145_abnormal_muscle_electrophysio3.01902076
7MP0006292_abnormal_olfactory_placode2.93741900
8MP0002928_abnormal_bile_duct2.69558009
9MP0008995_early_reproductive_senescence2.50809855
10MP0005671_abnormal_response_to2.44513988
11MP0003646_muscle_fatigue2.44059598
12MP0003787_abnormal_imprinting2.19171118
13MP0004885_abnormal_endolymph2.12708094
14MP0003186_abnormal_redox_activity2.12033489
15MP0004142_abnormal_muscle_tone2.10287190
16MP0005075_abnormal_melanosome_morpholog1.99963662
17MP0004742_abnormal_vestibular_system1.99011323
18MP0003806_abnormal_nucleotide_metabolis1.96133249
19MP0005084_abnormal_gallbladder_morpholo1.95527433
20MP0009333_abnormal_splenocyte_physiolog1.93106228
21MP0001849_ear_inflammation1.92873993
22MP0003786_premature_aging1.87454421
23MP0000049_abnormal_middle_ear1.85629435
24MP0003763_abnormal_thymus_physiology1.80528229
25MP0004381_abnormal_hair_follicle1.75916882
26MP0005379_endocrine/exocrine_gland_phen1.75318292
27MP0004858_abnormal_nervous_system1.74646399
28MP0002277_abnormal_respiratory_mucosa1.70384532
29MP0000685_abnormal_immune_system1.68582219
30MP0001800_abnormal_humoral_immune1.68014638
31MP0004147_increased_porphyrin_level1.57119941
32MP0005174_abnormal_tail_pigmentation1.54550635
33MP0003195_calcinosis1.53128030
34MP0002095_abnormal_skin_pigmentation1.46881697
35MP0003656_abnormal_erythrocyte_physiolo1.43378872
36MP0001835_abnormal_antigen_presentation1.36976496
37MP0000015_abnormal_ear_pigmentation1.35205911
38MP0002132_abnormal_respiratory_system1.33353007
39MP0008058_abnormal_DNA_repair1.32572021
40MP0005389_reproductive_system_phenotype1.27837360
41MP0002405_respiratory_system_inflammati1.27806210
42MP0002723_abnormal_immune_serum1.27686017
43MP0001188_hyperpigmentation1.23506017
44MP0005551_abnormal_eye_electrophysiolog1.23040180
45MP0000703_abnormal_thymus_morphology1.19788144
46MP0002398_abnormal_bone_marrow1.19625977
47MP0000013_abnormal_adipose_tissue1.18703945
48MP0002102_abnormal_ear_morphology1.15636640
49MP0002420_abnormal_adaptive_immunity1.15225045
50MP0001819_abnormal_immune_cell1.11628049
51MP0002160_abnormal_reproductive_system1.09693194
52MP0008877_abnormal_DNA_methylation1.08736102
53MP0001270_distended_abdomen1.06386839
54MP0008875_abnormal_xenobiotic_pharmacok1.05751600
55MP0001986_abnormal_taste_sensitivity1.04904380
56MP0000372_irregular_coat_pigmentation1.04685300
57MP0001919_abnormal_reproductive_system1.01930092
58MP0000716_abnormal_immune_system1.00382719
59MP0001790_abnormal_immune_system0.99883274
60MP0005387_immune_system_phenotype0.99883274
61MP0002452_abnormal_antigen_presenting0.95684231
62MP0001485_abnormal_pinna_reflex0.95553322
63MP0001905_abnormal_dopamine_level0.94580439
64MP0009785_altered_susceptibility_to0.94197073
65MP0002722_abnormal_immune_system0.93422675
66MP0005000_abnormal_immune_tolerance0.91675501
67MP0002429_abnormal_blood_cell0.91333002
68MP0005025_abnormal_response_to0.89868143
69MP0003879_abnormal_hair_cell0.89703850
70MP0000689_abnormal_spleen_morphology0.89680282
71MP0002638_abnormal_pupillary_reflex0.89090947
72MP0001440_abnormal_grooming_behavior0.86838090
73MP0003866_abnormal_defecation0.86494485
74MP0000750_abnormal_muscle_regeneration0.85902085
75MP0000762_abnormal_tongue_morphology0.82433530
76MP0002148_abnormal_hypersensitivity_rea0.81416963
77MP0003121_genomic_imprinting0.81002987
78MP0001663_abnormal_digestive_system0.78579670
79MP0005647_abnormal_sex_gland0.78134294
80MP0001293_anophthalmia0.75517337
81MP0001764_abnormal_homeostasis0.73439543
82MP0000678_abnormal_parathyroid_gland0.73391785
83MP0005266_abnormal_metabolism0.72648089
84MP0006036_abnormal_mitochondrial_physio0.72453369
85MP0003724_increased_susceptibility_to0.72029333
86MP0005636_abnormal_mineral_homeostasis0.71234419
87MP0008872_abnormal_physiological_respon0.70781704
88MP0008775_abnormal_heart_ventricle0.69598600
89MP0004130_abnormal_muscle_cell0.67849096
90MP0003943_abnormal_hepatobiliary_system0.66068033
91MP0002210_abnormal_sex_determination0.65148302
92MP0010307_abnormal_tumor_latency0.65012981
93MP0001661_extended_life_span0.64823054
94MP0005195_abnormal_posterior_eye0.64067771
95MP0006276_abnormal_autonomic_nervous0.63956849
96MP0009765_abnormal_xenobiotic_induced0.63933048
97MP0003011_delayed_dark_adaptation0.62971094
98MP0005646_abnormal_pituitary_gland0.62930714
99MP0002938_white_spotting0.62845211
100MP0001873_stomach_inflammation0.62270445

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.84480889
2Acute necrotizing encephalopathy (HP:0006965)4.63028964
3Acute encephalopathy (HP:0006846)4.54194201
4Abnormality of cells of the erythroid lineage (HP:0012130)4.52867739
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47486240
6Reticulocytopenia (HP:0001896)4.25533610
7Abnormal mitochondria in muscle tissue (HP:0008316)4.20574357
8Pallor (HP:0000980)4.00391045
9Limb hypertonia (HP:0002509)3.97340765
10Mitochondrial inheritance (HP:0001427)3.95843411
11Abnormal hemoglobin (HP:0011902)3.86276481
12Progressive macrocephaly (HP:0004481)3.77414307
13Cerebral edema (HP:0002181)3.75196970
14Macrocytic anemia (HP:0001972)3.70941822
15Abnormal number of erythroid precursors (HP:0012131)3.60838535
16Increased CSF lactate (HP:0002490)3.59788601
17Absent/shortened dynein arms (HP:0200106)3.36499320
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.36499320
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.35805788
20Increased hepatocellular lipid droplets (HP:0006565)3.10849609
21Increased intramyocellular lipid droplets (HP:0012240)3.08591305
22Abnormal rod and cone electroretinograms (HP:0008323)3.01212707
233-Methylglutaconic aciduria (HP:0003535)2.98220555
24Lipid accumulation in hepatocytes (HP:0006561)2.97420071
25Abnormality of macular pigmentation (HP:0008002)2.93154342
26Hyperglycinemia (HP:0002154)2.89714094
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85250219
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85250219
29Renal Fanconi syndrome (HP:0001994)2.85184940
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80589976
31Abnormal respiratory epithelium morphology (HP:0012253)2.79406678
32Abnormal respiratory motile cilium morphology (HP:0005938)2.79406678
33Increased muscle lipid content (HP:0009058)2.70123800
34Hepatocellular necrosis (HP:0001404)2.70007441
35Abnormality of T cells (HP:0002843)2.62325711
36Exertional dyspnea (HP:0002875)2.60813614
37Hyperglycinuria (HP:0003108)2.54656698
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.53504066
39Pendular nystagmus (HP:0012043)2.47549437
40Abnormality of T cell number (HP:0011839)2.45342979
41Lactic acidosis (HP:0003128)2.41175032
42Abnormality of DNA repair (HP:0003254)2.39477957
43Asplenia (HP:0001746)2.38158220
44T lymphocytopenia (HP:0005403)2.35779173
45Abnormal ciliary motility (HP:0012262)2.34946557
46Nephronophthisis (HP:0000090)2.32391727
47Hepatic necrosis (HP:0002605)2.29128396
48Microcytic anemia (HP:0001935)2.24458288
49Gastrointestinal infarctions (HP:0005244)2.23964894
50Respiratory difficulties (HP:0002880)2.22960172
51Increased serum lactate (HP:0002151)2.20421807
52Ketosis (HP:0001946)2.20082347
53Abnormality of T cell physiology (HP:0011840)2.19434867
54Abnormality of pyrimidine metabolism (HP:0004353)2.16096059
55Elevated erythrocyte sedimentation rate (HP:0003565)2.13837536
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13523915
57Abnormal respiratory motile cilium physiology (HP:0012261)2.11768478
58Septo-optic dysplasia (HP:0100842)2.10611842
59Poikilocytosis (HP:0004447)2.06709254
60Optic disc pallor (HP:0000543)2.02458005
61Deep palmar crease (HP:0006191)1.99021605
62Large eyes (HP:0001090)1.98374562
63Lethargy (HP:0001254)1.98149967
64Bilateral sensorineural hearing impairment (HP:0008619)1.97241544
65Hypochromic anemia (HP:0001931)1.96710744
66Abnormality of the renal medulla (HP:0100957)1.96541083
67Nasal polyposis (HP:0100582)1.95003254
68Congenital stationary night blindness (HP:0007642)1.92672523
69Decreased central vision (HP:0007663)1.92018377
70IgG deficiency (HP:0004315)1.91750861
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91697077
72Degeneration of the lateral corticospinal tracts (HP:0002314)1.91697077
73Vitreoretinal degeneration (HP:0000655)1.90543690
74Respiratory failure (HP:0002878)1.90534649
75Abolished electroretinogram (ERG) (HP:0000550)1.90018606
76Abnormality of glycine metabolism (HP:0010895)1.86170665
77Abnormality of serine family amino acid metabolism (HP:0010894)1.86170665
78Broad distal phalanx of finger (HP:0009836)1.85245283
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84994218
80Truncus arteriosus (HP:0001660)1.83552623
81Hypochromic microcytic anemia (HP:0004840)1.83016196
82Abnormality of renal resorption (HP:0011038)1.80697844
83Abnormality of midbrain morphology (HP:0002418)1.79922057
84Molar tooth sign on MRI (HP:0002419)1.79922057
85Absent thumb (HP:0009777)1.78403898
86Stenosis of the external auditory canal (HP:0000402)1.77185089
87Type 2 muscle fiber atrophy (HP:0003554)1.77023708
88Hyperthyroidism (HP:0000836)1.72545294
89Agitation (HP:0000713)1.71282585
90Rectal prolapse (HP:0002035)1.71121188
91IgM deficiency (HP:0002850)1.69992699
92Dysphonia (HP:0001618)1.69697069
93Constricted visual fields (HP:0001133)1.69365263
94Type II lissencephaly (HP:0007260)1.69198797
95Exercise intolerance (HP:0003546)1.68905699
96Limb dystonia (HP:0002451)1.67162927
97Leukodystrophy (HP:0002415)1.64831481
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63783136
99Pancytopenia (HP:0001876)1.63687639
100Abnormality of incisor morphology (HP:0011063)1.62861506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.04658380
2BCKDK4.03621982
3MAP3K134.02133087
4TXK3.90531630
5ARAF3.33614680
6TAOK33.08872750
7MAP4K13.05147691
8DMPK2.50900803
9MAP3K92.37271400
10LRRK22.27449659
11CAMKK22.00341541
12IRAK41.99197318
13BRAF1.97359338
14ZAK1.84786161
15BTK1.78393414
16RIPK41.71492616
17CDK41.46782584
18ADRBK21.44132776
19FES1.37811511
20RPS6KA51.33341575
21MOS1.31845028
22EPHA41.29289178
23WNK41.28585112
24RAF11.22588422
25GRK11.22051756
26PRKCQ1.21393657
27STK41.20196487
28KDR1.19695486
29GRK61.18746289
30PIK3CG1.16937623
31CSK1.09177155
32CAMK1D1.09125978
33SYK1.08350781
34PLK41.05295094
35IKBKE1.04610286
36KSR21.03384927
37CAMKK11.03224892
38ITK1.03213525
39NUAK11.02069743
40AKT31.00629431
41TEC0.97524317
42PDK20.96775315
43JAK30.94533403
44RPS6KA60.94252683
45PIM10.93537352
46FRK0.93275261
47ADRBK10.90007890
48IRAK20.85925751
49RPS6KL10.85261795
50RPS6KC10.85261795
51STK110.84539916
52CDK190.83880659
53CDC70.80362315
54LCK0.79573727
55DYRK20.77787787
56IKBKB0.76258103
57SGK10.72868966
58LYN0.72290955
59BLK0.68931983
60CSNK2A20.66122341
61RPS6KB20.66096127
62MATK0.64217876
63CAMK10.60883383
64PASK0.60624489
65WNK10.56094609
66DYRK1B0.55924824
67DYRK30.55117339
68TIE10.54320417
69MAPK120.53698058
70MUSK0.50496915
71CAMK1G0.50025599
72TNK20.49086087
73PRKCH0.47672996
74AURKA0.46909606
75PINK10.46443171
76FGR0.46323623
77AURKB0.45958581
78SGK2230.42818724
79SGK4940.42818724
80MAP3K100.41719128
81PRKACA0.41202947
82MAPKAPK50.40632376
83BMPR1B0.40612813
84ILK0.40256905
85GRK50.39502913
86PIK3CA0.39396588
87TLK10.38978493
88CHEK10.38543341
89ATR0.36553626
90MARK20.36437341
91AKT10.36091861
92CSNK2A10.35789849
93PAK30.35491987
94NLK0.34242478
95TYRO30.33245398
96OBSCN0.33097030
97RPS6KA10.32283823
98IGF1R0.31251934
99EIF2AK10.30900240
100SGK30.30815915

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.45790197
2Oxidative phosphorylation_Homo sapiens_hsa001904.44957605
3Parkinsons disease_Homo sapiens_hsa050123.93525436
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.92313267
5Huntingtons disease_Homo sapiens_hsa050162.70789230
6Alzheimers disease_Homo sapiens_hsa050102.60917321
7Cardiac muscle contraction_Homo sapiens_hsa042602.36340759
8RNA polymerase_Homo sapiens_hsa030202.06506595
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03263770
10Linoleic acid metabolism_Homo sapiens_hsa005911.97253695
11Primary immunodeficiency_Homo sapiens_hsa053401.94549222
12Basal transcription factors_Homo sapiens_hsa030221.82829480
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82234266
14Sulfur metabolism_Homo sapiens_hsa009201.80733131
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73891638
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70309712
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59436645
18Pyrimidine metabolism_Homo sapiens_hsa002401.55878617
19Sulfur relay system_Homo sapiens_hsa041221.45403858
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43064633
21One carbon pool by folate_Homo sapiens_hsa006701.40137466
22Fatty acid biosynthesis_Homo sapiens_hsa000611.39703418
23Graft-versus-host disease_Homo sapiens_hsa053321.22169567
24Allograft rejection_Homo sapiens_hsa053301.16291658
25Homologous recombination_Homo sapiens_hsa034401.16030093
26Autoimmune thyroid disease_Homo sapiens_hsa053201.15326248
27Asthma_Homo sapiens_hsa053101.14342332
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13233906
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.11908003
30Propanoate metabolism_Homo sapiens_hsa006401.09623503
31Arachidonic acid metabolism_Homo sapiens_hsa005901.08705404
32Protein export_Homo sapiens_hsa030601.06110473
33Proteasome_Homo sapiens_hsa030501.06078249
34Spliceosome_Homo sapiens_hsa030401.00846350
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97931465
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96848363
37Base excision repair_Homo sapiens_hsa034100.93789119
38Malaria_Homo sapiens_hsa051440.91322210
39RNA degradation_Homo sapiens_hsa030180.90065715
40Fanconi anemia pathway_Homo sapiens_hsa034600.86727100
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85601077
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81748077
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81092428
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.79847002
45Hematopoietic cell lineage_Homo sapiens_hsa046400.75868637
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75041631
47T cell receptor signaling pathway_Homo sapiens_hsa046600.74889680
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74126163
49B cell receptor signaling pathway_Homo sapiens_hsa046620.73249358
50Ether lipid metabolism_Homo sapiens_hsa005650.73206500
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72541566
52Fat digestion and absorption_Homo sapiens_hsa049750.72429437
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68123290
54Dorso-ventral axis formation_Homo sapiens_hsa043200.65986768
55Systemic lupus erythematosus_Homo sapiens_hsa053220.65860603
56Purine metabolism_Homo sapiens_hsa002300.65486841
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65160506
58Metabolic pathways_Homo sapiens_hsa011000.64971828
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.63227689
60Type I diabetes mellitus_Homo sapiens_hsa049400.62278795
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.61638116
62Leishmaniasis_Homo sapiens_hsa051400.61272328
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.59433548
64Nitrogen metabolism_Homo sapiens_hsa009100.57187626
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56893818
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55234500
67RNA transport_Homo sapiens_hsa030130.53413880
68Nucleotide excision repair_Homo sapiens_hsa034200.48767001
69Olfactory transduction_Homo sapiens_hsa047400.46420518
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45194422
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44696274
72Mismatch repair_Homo sapiens_hsa034300.42022352
73Measles_Homo sapiens_hsa051620.41807309
74Phototransduction_Homo sapiens_hsa047440.41538709
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41309907
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40185895
77Folate biosynthesis_Homo sapiens_hsa007900.40040253
78Antigen processing and presentation_Homo sapiens_hsa046120.38822494
79Chemokine signaling pathway_Homo sapiens_hsa040620.38498672
80Peroxisome_Homo sapiens_hsa041460.37461177
81Nicotine addiction_Homo sapiens_hsa050330.35541964
82DNA replication_Homo sapiens_hsa030300.35253027
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34443376
84Tyrosine metabolism_Homo sapiens_hsa003500.33224918
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29019770
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28868335
87Rheumatoid arthritis_Homo sapiens_hsa053230.28514097
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.28188340
89Pancreatic secretion_Homo sapiens_hsa049720.27406445
90Morphine addiction_Homo sapiens_hsa050320.26701977
91Herpes simplex infection_Homo sapiens_hsa051680.26301873
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23946430
93Non-small cell lung cancer_Homo sapiens_hsa052230.22557166
94Staphylococcus aureus infection_Homo sapiens_hsa051500.22272695
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20755159
96ABC transporters_Homo sapiens_hsa020100.20343972
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19954241
98Epstein-Barr virus infection_Homo sapiens_hsa051690.19539655
99Melanoma_Homo sapiens_hsa052180.19065014
100Notch signaling pathway_Homo sapiens_hsa043300.19003931

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