RPL13AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.18765394
2translational termination (GO:0006415)7.82768830
3ribosomal small subunit assembly (GO:0000028)7.68262997
4translational elongation (GO:0006414)6.69167595
5ribosomal small subunit biogenesis (GO:0042274)6.66435510
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.59548209
7cotranslational protein targeting to membrane (GO:0006613)6.50295542
8protein targeting to ER (GO:0045047)6.48472349
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.19341939
10protein localization to endoplasmic reticulum (GO:0070972)6.07482863
11cellular protein complex disassembly (GO:0043624)5.93682583
12maturation of SSU-rRNA (GO:0030490)5.82058810
13viral life cycle (GO:0019058)5.79738408
14ATP synthesis coupled proton transport (GO:0015986)5.68234737
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.68234737
16DNA deamination (GO:0045006)5.60023585
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.59703650
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.52631002
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.52567180
20translational initiation (GO:0006413)5.14128092
21protein complex disassembly (GO:0043241)4.96431237
22cytidine deamination (GO:0009972)4.73732550
23cytidine metabolic process (GO:0046087)4.73732550
24cytidine catabolic process (GO:0006216)4.73732550
25chaperone-mediated protein transport (GO:0072321)4.69987694
26macromolecular complex disassembly (GO:0032984)4.66718788
27behavioral response to nicotine (GO:0035095)4.35588345
28ribosomal large subunit biogenesis (GO:0042273)4.35434274
29protein targeting to membrane (GO:0006612)4.27164477
30protein neddylation (GO:0045116)4.17978782
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15002296
32pyrimidine ribonucleoside catabolic process (GO:0046133)4.11164876
33protein complex biogenesis (GO:0070271)4.09900627
34* translation (GO:0006412)4.06261867
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96935795
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.96935795
37NADH dehydrogenase complex assembly (GO:0010257)3.96935795
38respiratory electron transport chain (GO:0022904)3.95635340
39electron transport chain (GO:0022900)3.92616250
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.89516383
41mitochondrial respiratory chain complex assembly (GO:0033108)3.70434269
42mRNA catabolic process (GO:0006402)3.68076155
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.65543583
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57575198
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57575198
46negative regulation of telomere maintenance (GO:0032205)3.56210263
47ATP biosynthetic process (GO:0006754)3.38599030
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32201675
49RNA catabolic process (GO:0006401)3.30493305
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28219822
51cellular component biogenesis (GO:0044085)3.15065936
52GTP biosynthetic process (GO:0006183)3.11943383
53water-soluble vitamin biosynthetic process (GO:0042364)3.10482480
54ribonucleoprotein complex biogenesis (GO:0022613)3.06232209
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05280633
56hydrogen ion transmembrane transport (GO:1902600)3.04524322
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94596373
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94336463
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93972014
60cell proliferation in forebrain (GO:0021846)2.91652059
61somite development (GO:0061053)2.88005796
62positive regulation of T cell apoptotic process (GO:0070234)2.86589701
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.84480443
64termination of RNA polymerase III transcription (GO:0006386)2.84480443
65establishment of protein localization to membrane (GO:0090150)2.83528827
66negative regulation of telomerase activity (GO:0051974)2.81556150
67substrate-independent telencephalic tangential migration (GO:0021826)2.81146325
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.81146325
69positive regulation of cell fate commitment (GO:0010455)2.78592210
70proton transport (GO:0015992)2.77283845
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76767534
72CTP metabolic process (GO:0046036)2.74158856
73CTP biosynthetic process (GO:0006241)2.74158856
74rRNA processing (GO:0006364)2.73137895
75rRNA metabolic process (GO:0016072)2.71885728
76regulation of isotype switching to IgG isotypes (GO:0048302)2.70471708
77regulation of activation of Janus kinase activity (GO:0010533)2.69725671
78hydrogen transport (GO:0006818)2.69240053
79cellular anion homeostasis (GO:0030002)2.65596963
80protein targeting (GO:0006605)2.64338863
81positive regulation of respiratory burst (GO:0060267)2.57837778
82nucleoside triphosphate biosynthetic process (GO:0009142)2.57676891
83regulation of telomerase activity (GO:0051972)2.57178475
84platelet dense granule organization (GO:0060155)2.56583867
85negative regulation of T cell differentiation in thymus (GO:0033085)2.56218058
86protein-cofactor linkage (GO:0018065)2.55158815
87pyrimidine ribonucleoside metabolic process (GO:0046131)2.55049685
88UTP biosynthetic process (GO:0006228)2.54736333
89positive regulation of defense response to virus by host (GO:0002230)2.53996413
90tongue development (GO:0043586)2.53862384
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52574910
92establishment of protein localization to organelle (GO:0072594)2.52167820
93cytochrome complex assembly (GO:0017004)2.49049364
94respiratory chain complex IV assembly (GO:0008535)2.47315650
95pyrimidine nucleotide catabolic process (GO:0006244)2.44980754
96sequestering of actin monomers (GO:0042989)2.44436091
97positive regulation of prostaglandin secretion (GO:0032308)2.42744703
98fucose catabolic process (GO:0019317)2.40182563
99L-fucose metabolic process (GO:0042354)2.40182563
100L-fucose catabolic process (GO:0042355)2.40182563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40111168
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00608935
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76125346
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.23655785
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97189458
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89370355
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78630964
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.76621546
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75029351
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53103856
11VDR_22108803_ChIP-Seq_LS180_Human2.32616906
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.30736939
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30039741
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00493809
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.96773595
16MYC_18940864_ChIP-ChIP_HL60_Human1.94443130
17ZNF274_21170338_ChIP-Seq_K562_Hela1.92451741
18VDR_23849224_ChIP-Seq_CD4+_Human1.85840551
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81969961
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.75336876
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74190504
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61333192
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60920533
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.58461497
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57697784
26FOXP3_21729870_ChIP-Seq_TREG_Human1.51946196
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48953916
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.47306403
29TP53_22573176_ChIP-Seq_HFKS_Human1.47197397
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42129797
31IGF1R_20145208_ChIP-Seq_DFB_Human1.41032445
32ELK1_19687146_ChIP-ChIP_HELA_Human1.40500374
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.39849855
34NANOG_20526341_ChIP-Seq_ESCs_Human1.38030808
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37205971
36TAF2_19829295_ChIP-Seq_ESCs_Human1.37154002
37IRF1_19129219_ChIP-ChIP_H3396_Human1.36932548
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.35211820
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33200365
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.32492567
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.31384781
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29391593
43ERA_21632823_ChIP-Seq_H3396_Human1.28726443
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28144652
45TTF2_22483619_ChIP-Seq_HELA_Human1.28111883
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26936452
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25816051
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25327847
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24558395
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.24303537
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24272172
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.23543930
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23084314
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.23084314
55NCOR_22424771_ChIP-Seq_293T_Human1.21498110
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20165122
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19956049
58AR_20517297_ChIP-Seq_VCAP_Human1.19375218
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19230464
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19101471
61XRN2_22483619_ChIP-Seq_HELA_Human1.18004765
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.16933261
63EWS_26573619_Chip-Seq_HEK293_Human1.16675076
64CTCF_20526341_ChIP-Seq_ESCs_Human1.12625696
65P53_21459846_ChIP-Seq_SAOS-2_Human1.12124825
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11727452
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11464878
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09731290
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09664016
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09239349
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07498828
72REST_21632747_ChIP-Seq_MESCs_Mouse1.06848376
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06306176
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06289680
75PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06231858
76* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04932177
77FUS_26573619_Chip-Seq_HEK293_Human1.04927323
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04187532
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.03942385
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03430280
81MYC_19829295_ChIP-Seq_ESCs_Human1.02937845
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01923676
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01517150
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01451181
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01324637
86RNF2_27304074_Chip-Seq_NSC_Mouse1.00265289
87BCL6_27268052_Chip-Seq_Bcells_Human0.99428756
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99029056
89MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98736874
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97990667
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.96033424
92RNF2_27304074_Chip-Seq_ESCs_Mouse0.94801781
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94025690
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93852130
95FOXH1_21741376_ChIP-Seq_ESCs_Human0.93220919
96SA1_27219007_Chip-Seq_Bcells_Human0.93060514
97ERG_20517297_ChIP-Seq_VCAP_Human0.92645463
98HOXB7_26014856_ChIP-Seq_BT474_Human0.92537231
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91645618
100GATA3_21867929_ChIP-Seq_TH1_Mouse0.91066457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.01970239
2MP0006292_abnormal_olfactory_placode4.58746320
3MP0002234_abnormal_pharynx_morphology3.34899103
4MP0005671_abnormal_response_to2.61884388
5MP0002653_abnormal_ependyma_morphology2.57975413
6MP0002163_abnormal_gland_morphology2.55422340
7MP0003646_muscle_fatigue2.43680457
8MP0001873_stomach_inflammation2.29848363
9MP0003787_abnormal_imprinting2.24695375
10MP0008789_abnormal_olfactory_epithelium2.02383288
11MP0008877_abnormal_DNA_methylation1.99925176
12MP0002102_abnormal_ear_morphology1.85221367
13MP0004142_abnormal_muscle_tone1.82936159
14MP0006072_abnormal_retinal_apoptosis1.74472055
15MP0002837_dystrophic_cardiac_calcinosis1.72252906
16MP0008872_abnormal_physiological_respon1.68383802
17MP0008875_abnormal_xenobiotic_pharmacok1.66587787
18MP0005551_abnormal_eye_electrophysiolog1.64691465
19MP0003011_delayed_dark_adaptation1.63999465
20MP0000049_abnormal_middle_ear1.61130209
21MP0005394_taste/olfaction_phenotype1.60675830
22MP0005499_abnormal_olfactory_system1.60675830
23MP0004885_abnormal_endolymph1.58564134
24MP0003878_abnormal_ear_physiology1.55869752
25MP0005377_hearing/vestibular/ear_phenot1.55869752
26MP0005645_abnormal_hypothalamus_physiol1.52961631
27MP0005379_endocrine/exocrine_gland_phen1.48106734
28MP0001293_anophthalmia1.47087616
29MP0001485_abnormal_pinna_reflex1.43251591
30MP0006276_abnormal_autonomic_nervous1.40361449
31MP0001188_hyperpigmentation1.34444051
32MP0002277_abnormal_respiratory_mucosa1.33193020
33MP0004147_increased_porphyrin_level1.33100145
34MP0000372_irregular_coat_pigmentation1.28340510
35MP0000631_abnormal_neuroendocrine_gland1.26828580
36MP0002938_white_spotting1.24707739
37MP0001968_abnormal_touch/_nociception1.24666811
38MP0005646_abnormal_pituitary_gland1.24042078
39MP0002736_abnormal_nociception_after1.20433638
40MP0003880_abnormal_central_pattern1.20085707
41MP0000566_synostosis1.19619090
42MP0005389_reproductive_system_phenotype1.16935413
43MP0002638_abnormal_pupillary_reflex1.16800625
44MP0001905_abnormal_dopamine_level1.15400751
45MP0001919_abnormal_reproductive_system1.13536910
46MP0010030_abnormal_orbit_morphology1.13201621
47MP0004145_abnormal_muscle_electrophysio1.12729840
48MP0001986_abnormal_taste_sensitivity1.09379020
49MP0002272_abnormal_nervous_system1.07940126
50MP0008995_early_reproductive_senescence1.06764098
51MP0004133_heterotaxia1.06738812
52MP0001800_abnormal_humoral_immune1.05536986
53MP0005075_abnormal_melanosome_morpholog1.05043033
54MP0001984_abnormal_olfaction1.03582805
55MP0004742_abnormal_vestibular_system1.02951343
56MP0005084_abnormal_gallbladder_morpholo1.02605734
57MP0002095_abnormal_skin_pigmentation1.01544039
58MP0001440_abnormal_grooming_behavior1.00766341
59MP0001835_abnormal_antigen_presentation1.00581104
60MP0002160_abnormal_reproductive_system0.99832757
61MP0001529_abnormal_vocalization0.99174369
62MP0005253_abnormal_eye_physiology0.98546829
63MP0003122_maternal_imprinting0.98184821
64MP0003938_abnormal_ear_development0.97401823
65MP0005423_abnormal_somatic_nervous0.97130822
66MP0001663_abnormal_digestive_system0.95446595
67MP0009745_abnormal_behavioral_response0.95143887
68MP0003136_yellow_coat_color0.93490513
69MP0005195_abnormal_posterior_eye0.93292123
70MP0003121_genomic_imprinting0.93070031
71MP0002822_catalepsy0.91201447
72MP0002876_abnormal_thyroid_physiology0.90405344
73MP0003763_abnormal_thymus_physiology0.90153490
74MP0001348_abnormal_lacrimal_gland0.88036605
75MP0005360_urolithiasis0.86534747
76MP0000026_abnormal_inner_ear0.86431890
77MP0003283_abnormal_digestive_organ0.83808163
78MP0009333_abnormal_splenocyte_physiolog0.82885269
79MP0002752_abnormal_somatic_nervous0.82453190
80MP0002138_abnormal_hepatobiliary_system0.80842052
81MP0002148_abnormal_hypersensitivity_rea0.80278920
82MP0002733_abnormal_thermal_nociception0.79498617
83MP0002723_abnormal_immune_serum0.79403364
84MP0003123_paternal_imprinting0.78856742
85MP0001970_abnormal_pain_threshold0.78836805
86MP0002184_abnormal_innervation0.77137439
87MP0008058_abnormal_DNA_repair0.76692041
88MP0005000_abnormal_immune_tolerance0.75649983
89MP0009785_altered_susceptibility_to0.75503758
90MP0005174_abnormal_tail_pigmentation0.73140776
91MP0001790_abnormal_immune_system0.71923414
92MP0005387_immune_system_phenotype0.71923414
93MP0003866_abnormal_defecation0.71858559
94MP0001963_abnormal_hearing_physiology0.70882039
95MP0002420_abnormal_adaptive_immunity0.70153545
96MP0001819_abnormal_immune_cell0.68838903
97MP0003567_abnormal_fetal_cardiomyocyte0.68094676
98MP0005381_digestive/alimentary_phenotyp0.66078751
99MP0009764_decreased_sensitivity_to0.65341251
100MP0003806_abnormal_nucleotide_metabolis0.65317077

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.53691077
2Abnormality of cells of the erythroid lineage (HP:0012130)4.35480017
3Acute necrotizing encephalopathy (HP:0006965)4.06975067
4Increased hepatocellular lipid droplets (HP:0006565)3.88109893
5Mitochondrial inheritance (HP:0001427)3.87471795
6Abnormal number of erythroid precursors (HP:0012131)3.82015873
7Macrocytic anemia (HP:0001972)3.67400787
8Abnormal mitochondria in muscle tissue (HP:0008316)3.61945587
9Increased IgM level (HP:0003496)3.57624966
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.56430202
11Lipid accumulation in hepatocytes (HP:0006561)3.51093766
12Acute encephalopathy (HP:0006846)3.44259207
13Renal Fanconi syndrome (HP:0001994)3.42370556
14Abnormality of midbrain morphology (HP:0002418)3.39514898
15Molar tooth sign on MRI (HP:0002419)3.39514898
16Increased CSF lactate (HP:0002490)3.36393524
17Progressive macrocephaly (HP:0004481)3.25992969
18Pancreatic fibrosis (HP:0100732)3.14605983
19Pancreatic cysts (HP:0001737)3.09054950
20Congenital stationary night blindness (HP:0007642)3.06066247
21Abnormal rod and cone electroretinograms (HP:0008323)2.94066797
22Increased intramyocellular lipid droplets (HP:0012240)2.91447717
23Pallor (HP:0000980)2.85959456
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84869673
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84869673
26Hepatocellular necrosis (HP:0001404)2.74344911
27True hermaphroditism (HP:0010459)2.67499490
28IgG deficiency (HP:0004315)2.66967859
29Elevated erythrocyte sedimentation rate (HP:0003565)2.65025794
30Autoimmune thrombocytopenia (HP:0001973)2.64661376
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64106181
32Cerebral edema (HP:0002181)2.63068429
33Type II lissencephaly (HP:0007260)2.62892970
34Exertional dyspnea (HP:0002875)2.62859730
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.59282414
363-Methylglutaconic aciduria (HP:0003535)2.58239405
37Nephronophthisis (HP:0000090)2.50180970
38Hepatic necrosis (HP:0002605)2.45615901
39Septo-optic dysplasia (HP:0100842)2.44393064
40Increased muscle lipid content (HP:0009058)2.41806981
41Optic disc pallor (HP:0000543)2.41682599
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.37483181
43Absent/shortened dynein arms (HP:0200106)2.37483181
44Rib fusion (HP:0000902)2.30459013
45Abnormality of renal resorption (HP:0011038)2.27505891
46Hyperglycinemia (HP:0002154)2.27196676
47Severe combined immunodeficiency (HP:0004430)2.26515614
48Medial flaring of the eyebrow (HP:0010747)2.25709927
49Polydipsia (HP:0001959)2.25247267
50Abnormal drinking behavior (HP:0030082)2.25247267
51Asplenia (HP:0001746)2.23403588
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.22369777
53Pendular nystagmus (HP:0012043)2.21942323
54Stomatitis (HP:0010280)2.21355371
55Congenital, generalized hypertrichosis (HP:0004540)2.21060012
56Abnormality of eosinophils (HP:0001879)2.20505711
57Aplastic anemia (HP:0001915)2.19432142
58Abnormality of urine glucose concentration (HP:0011016)2.19305292
59Glycosuria (HP:0003076)2.19305292
60Colon cancer (HP:0003003)2.18438612
61Absent thumb (HP:0009777)2.17743755
62Stenosis of the external auditory canal (HP:0000402)2.17037379
63Cystic liver disease (HP:0006706)2.16074757
64Abnormality of T cell number (HP:0011839)2.13716532
65Sclerocornea (HP:0000647)2.13267253
66Increased serum lactate (HP:0002151)2.09019366
67Abolished electroretinogram (ERG) (HP:0000550)2.06417991
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05782738
69Autoimmune hemolytic anemia (HP:0001890)2.05391061
70Lactic acidosis (HP:0003128)2.04260177
71Respiratory difficulties (HP:0002880)2.02457710
72Hyperphosphaturia (HP:0003109)2.02143191
73Abnormality of the renal medulla (HP:0100957)2.01196210
74Abnormal respiratory epithelium morphology (HP:0012253)2.00344412
75Abnormal respiratory motile cilium morphology (HP:0005938)2.00344412
76Lethargy (HP:0001254)1.96670552
77Abnormality of T cells (HP:0002843)1.92525665
78Decreased central vision (HP:0007663)1.92222995
79Abnormality of the renal cortex (HP:0011035)1.90813630
80Anterior segment dysgenesis (HP:0007700)1.90355237
81Respiratory failure (HP:0002878)1.89012685
82Chronic hepatic failure (HP:0100626)1.88348829
83Nonprogressive disorder (HP:0003680)1.88128767
84Abnormality of the renal collecting system (HP:0004742)1.85730688
85Abnormality of T cell physiology (HP:0011840)1.85618575
86Abnormality of the labia minora (HP:0012880)1.81422538
87Abnormal respiratory motile cilium physiology (HP:0012261)1.80569184
88Cerebellar dysplasia (HP:0007033)1.78505452
89Depressed nasal ridge (HP:0000457)1.78471514
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78178690
91Polyuria (HP:0000103)1.77608569
92Abnormal ciliary motility (HP:0012262)1.77285021
93Hypoplasia of the radius (HP:0002984)1.76735119
94Neutropenia (HP:0001875)1.75922747
95Supernumerary spleens (HP:0009799)1.73294174
96Hypoplasia of the pons (HP:0012110)1.73099555
97Methylmalonic acidemia (HP:0002912)1.71812911
98Abnormality of the pons (HP:0007361)1.71674999
99Thyroiditis (HP:0100646)1.70587988
100Constricted visual fields (HP:0001133)1.68491268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.75849500
2BCKDK3.36161732
3TXK3.31333741
4CDK193.12046266
5VRK23.06812330
6PIK3CA2.54872787
7ADRBK22.45114115
8WNK42.42137217
9TAOK32.21027065
10ZAK2.11238225
11MAP4K22.08305923
12GRK12.04301746
13NUAK11.86108213
14KDR1.83299518
15STK161.83023642
16DYRK21.69287791
17LIMK11.68861629
18MAP4K11.60825248
19TESK21.59280929
20TIE11.52109022
21OXSR11.50199064
22VRK11.47324531
23PASK1.39750576
24MAP2K61.39472247
25CAMKK21.39253593
26NME11.35345710
27KIT1.35162686
28TAF11.34122809
29PINK11.26112442
30MAP3K111.23969790
31FRK1.10796296
32BMPR1B1.10224589
33WNK31.05913790
34TEC1.04778006
35GRK71.02515362
36STK390.97780603
37MUSK0.97425332
38PRKCQ0.96770708
39EPHB20.94397954
40PRKCG0.93762716
41GRK60.88618516
42ITK0.88099629
43ADRBK10.88064218
44PLK40.86837658
45BTK0.80852175
46GRK50.79467093
47LRRK20.78763587
48IKBKB0.76498362
49INSRR0.76223496
50CDK80.74069125
51CAMKK10.73082232
52SYK0.70242337
53LCK0.69241276
54DAPK30.68451800
55AURKA0.64544756
56CAMK10.62684793
57STK110.61149912
58RPS6KA50.59650810
59MATK0.58174916
60CSNK2A20.55035078
61TNIK0.52378520
62MAP3K120.52074864
63PRKACA0.52063638
64MST40.50376000
65DAPK20.49818529
66CDC70.49304154
67PAK30.49214031
68CSNK1G10.48529934
69MAP3K40.46149672
70MAPK130.45669758
71PIM10.45009230
72TNK20.44330613
73PRKCA0.42796583
74PRKCH0.42784072
75RPS6KA60.42695280
76CSNK1G30.42679384
77LYN0.42586709
78FES0.42567342
79OBSCN0.42435958
80CSNK2A10.41879127
81MARK30.41287626
82IKBKE0.40648618
83NME20.39134049
84NTRK20.39126063
85MAP3K60.38981139
86TESK10.38494955
87CSNK1G20.38220458
88PHKG10.37231018
89PHKG20.37231018
90MAP2K70.36246070
91SGK2230.35428283
92SGK4940.35428283
93NEK20.33976900
94WNK10.33790500
95AURKB0.33627817
96TAOK20.33594075
97TGFBR10.33529617
98CHEK20.32361638
99MAPKAPK50.31590535
100CSNK1A10.30748395

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.56823143
2Oxidative phosphorylation_Homo sapiens_hsa001904.18067653
3Parkinsons disease_Homo sapiens_hsa050123.28131271
4Primary immunodeficiency_Homo sapiens_hsa053402.77616000
5RNA polymerase_Homo sapiens_hsa030202.42898645
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31053680
7Alzheimers disease_Homo sapiens_hsa050102.27990667
8Huntingtons disease_Homo sapiens_hsa050162.25053963
9Sulfur relay system_Homo sapiens_hsa041222.21594744
10Linoleic acid metabolism_Homo sapiens_hsa005912.18789038
11Cardiac muscle contraction_Homo sapiens_hsa042602.16281691
12Caffeine metabolism_Homo sapiens_hsa002322.14751786
13Proteasome_Homo sapiens_hsa030502.11643372
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87987558
15Protein export_Homo sapiens_hsa030601.87027538
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80064254
17Phototransduction_Homo sapiens_hsa047441.79249817
18Allograft rejection_Homo sapiens_hsa053301.73388247
19Homologous recombination_Homo sapiens_hsa034401.64860719
20Autoimmune thyroid disease_Homo sapiens_hsa053201.62615146
21Graft-versus-host disease_Homo sapiens_hsa053321.58272835
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55350433
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38207058
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36087790
25Type I diabetes mellitus_Homo sapiens_hsa049401.31954029
26RNA degradation_Homo sapiens_hsa030181.28232502
27Pyrimidine metabolism_Homo sapiens_hsa002401.28153362
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27876784
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20807366
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13672820
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.13574391
32Asthma_Homo sapiens_hsa053101.08631907
33Ether lipid metabolism_Homo sapiens_hsa005651.06378305
34Arachidonic acid metabolism_Homo sapiens_hsa005901.02012352
35Fanconi anemia pathway_Homo sapiens_hsa034601.00727117
36Nucleotide excision repair_Homo sapiens_hsa034201.00542742
37Mismatch repair_Homo sapiens_hsa034301.00251048
38Hematopoietic cell lineage_Homo sapiens_hsa046401.00134149
39Fat digestion and absorption_Homo sapiens_hsa049750.98588582
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97469843
41Basal transcription factors_Homo sapiens_hsa030220.94984862
42Retinol metabolism_Homo sapiens_hsa008300.94742453
43Nitrogen metabolism_Homo sapiens_hsa009100.93526271
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89865089
45Chemical carcinogenesis_Homo sapiens_hsa052040.86264052
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.85636321
47One carbon pool by folate_Homo sapiens_hsa006700.85316457
48Peroxisome_Homo sapiens_hsa041460.85217398
49DNA replication_Homo sapiens_hsa030300.84895747
50Nicotine addiction_Homo sapiens_hsa050330.84679893
51Purine metabolism_Homo sapiens_hsa002300.84321749
52Tryptophan metabolism_Homo sapiens_hsa003800.84022860
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.82341202
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81485097
55Antigen processing and presentation_Homo sapiens_hsa046120.78258905
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75608651
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75230030
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73078530
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70796195
60Folate biosynthesis_Homo sapiens_hsa007900.69689658
61Butanoate metabolism_Homo sapiens_hsa006500.69126483
62T cell receptor signaling pathway_Homo sapiens_hsa046600.66576543
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65918166
64Propanoate metabolism_Homo sapiens_hsa006400.65621484
65Olfactory transduction_Homo sapiens_hsa047400.62454064
66Metabolic pathways_Homo sapiens_hsa011000.62262643
67Vitamin digestion and absorption_Homo sapiens_hsa049770.59327642
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58709330
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.55389410
70Basal cell carcinoma_Homo sapiens_hsa052170.55385963
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54866771
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53886136
73Rheumatoid arthritis_Homo sapiens_hsa053230.49585253
74African trypanosomiasis_Homo sapiens_hsa051430.49370176
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49017277
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48140440
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47135380
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44694285
79Base excision repair_Homo sapiens_hsa034100.44519078
80Spliceosome_Homo sapiens_hsa030400.44353359
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43360973
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42871440
83Collecting duct acid secretion_Homo sapiens_hsa049660.41365534
84Hedgehog signaling pathway_Homo sapiens_hsa043400.40282002
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38974584
86Morphine addiction_Homo sapiens_hsa050320.38590912
87Selenocompound metabolism_Homo sapiens_hsa004500.38219869
88Taste transduction_Homo sapiens_hsa047420.36233112
89RNA transport_Homo sapiens_hsa030130.36004293
90Measles_Homo sapiens_hsa051620.30367654
91Mineral absorption_Homo sapiens_hsa049780.29562217
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28930934
93Ovarian steroidogenesis_Homo sapiens_hsa049130.28074505
94Regulation of autophagy_Homo sapiens_hsa041400.26491213
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.23928742
96Malaria_Homo sapiens_hsa051440.22789990
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.19356558
98Salivary secretion_Homo sapiens_hsa049700.19185380
99Glycerolipid metabolism_Homo sapiens_hsa005610.18372552
100Systemic lupus erythematosus_Homo sapiens_hsa053220.16616743

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