RPL13AP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.39128906
2DNA deamination (GO:0045006)6.91705508
3viral transcription (GO:0019083)6.48065299
4translational termination (GO:0006415)6.18642181
5cytidine catabolic process (GO:0006216)5.71929872
6cytidine deamination (GO:0009972)5.71929872
7cytidine metabolic process (GO:0046087)5.71929872
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.68998972
9ribosomal small subunit biogenesis (GO:0042274)5.54032498
10translational elongation (GO:0006414)5.47194993
11maturation of SSU-rRNA (GO:0030490)5.46924955
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29875107
13cotranslational protein targeting to membrane (GO:0006613)5.20378767
14protein targeting to ER (GO:0045047)5.17955980
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.93537245
16protein localization to endoplasmic reticulum (GO:0070972)4.89662591
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.86273508
18viral life cycle (GO:0019058)4.67567205
19cellular protein complex disassembly (GO:0043624)4.59746788
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.43592621
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31550360
22ATP synthesis coupled proton transport (GO:0015986)4.31550360
23translational initiation (GO:0006413)4.14570921
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14012801
25ribosomal large subunit biogenesis (GO:0042273)3.97605380
26behavioral response to nicotine (GO:0035095)3.91055750
27protein complex disassembly (GO:0043241)3.78861946
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.73268503
29protein neddylation (GO:0045116)3.66847951
30iron-sulfur cluster assembly (GO:0016226)3.66366647
31metallo-sulfur cluster assembly (GO:0031163)3.66366647
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59032074
33macromolecular complex disassembly (GO:0032984)3.57951399
34translation (GO:0006412)3.54883263
35protein complex biogenesis (GO:0070271)3.54803331
36positive regulation of prostaglandin secretion (GO:0032308)3.46960211
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46958987
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.45177523
39NADH dehydrogenase complex assembly (GO:0010257)3.45177523
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45177523
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39241290
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39241290
43protein targeting to membrane (GO:0006612)3.37408116
44pseudouridine synthesis (GO:0001522)3.35850730
45chaperone-mediated protein transport (GO:0072321)3.34062283
46ribonucleoprotein complex biogenesis (GO:0022613)3.28871985
47base-excision repair, AP site formation (GO:0006285)3.21880631
48electron transport chain (GO:0022900)3.21678826
49cellular component biogenesis (GO:0044085)3.18488087
50respiratory electron transport chain (GO:0022904)3.17753358
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.10379689
52mitochondrial respiratory chain complex assembly (GO:0033108)3.09665636
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.07799787
54positive regulation of defense response to virus by host (GO:0002230)3.07283134
55pyrimidine nucleotide catabolic process (GO:0006244)3.00168251
56positive regulation of fatty acid transport (GO:2000193)2.95347183
57mRNA catabolic process (GO:0006402)2.92042932
58preassembly of GPI anchor in ER membrane (GO:0016254)2.91829454
59deoxyribonucleotide catabolic process (GO:0009264)2.91692276
60pyrimidine nucleoside catabolic process (GO:0046135)2.89884973
61water-soluble vitamin biosynthetic process (GO:0042364)2.89242596
62GPI anchor metabolic process (GO:0006505)2.87198364
63ubiquinone biosynthetic process (GO:0006744)2.84347608
64regulation of regulatory T cell differentiation (GO:0045589)2.82266784
65positive regulation of icosanoid secretion (GO:0032305)2.77864901
66positive thymic T cell selection (GO:0045059)2.77847058
67GPI anchor biosynthetic process (GO:0006506)2.77845856
68positive regulation of respiratory burst (GO:0060267)2.76995171
69deoxyribose phosphate catabolic process (GO:0046386)2.76290653
70positive T cell selection (GO:0043368)2.74118646
71negative regulation by host of viral transcription (GO:0043922)2.71835055
72sequestering of actin monomers (GO:0042989)2.68977708
73mannosylation (GO:0097502)2.68665251
74negative regulation of telomere maintenance (GO:0032205)2.68282345
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62384122
76RNA catabolic process (GO:0006401)2.61318641
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60493757
78positive regulation of calcium-mediated signaling (GO:0050850)2.59794200
79positive regulation of T cell apoptotic process (GO:0070234)2.58723405
80negative T cell selection (GO:0043383)2.58717724
81positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57420927
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56761878
83piRNA metabolic process (GO:0034587)2.56682265
84ATP biosynthetic process (GO:0006754)2.56471901
85purine deoxyribonucleotide catabolic process (GO:0009155)2.55457497
86regulation of prostaglandin secretion (GO:0032306)2.55209426
87ncRNA 3-end processing (GO:0043628)2.55132295
88pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54831327
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.53368474
90rRNA processing (GO:0006364)2.52181787
91purine nucleoside triphosphate biosynthetic process (GO:0009145)2.51268402
92rRNA metabolic process (GO:0016072)2.50343242
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49482322
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49194344
95response to pheromone (GO:0019236)2.48861714
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.48770075
97Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46192388
98platelet dense granule organization (GO:0060155)2.46012038
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45855353
100DNA demethylation (GO:0080111)2.45264671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.38451403
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.37123542
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.27160968
4EZH2_22144423_ChIP-Seq_EOC_Human2.99635209
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73891422
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69936197
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55263259
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48041798
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.46261122
10VDR_22108803_ChIP-Seq_LS180_Human2.44631346
11ZNF274_21170338_ChIP-Seq_K562_Hela2.43015511
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42336296
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39373739
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.34542976
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32679174
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.22029667
17VDR_23849224_ChIP-Seq_CD4+_Human2.09919979
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.05896589
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02085560
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99777578
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85231416
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73074271
23MYC_18940864_ChIP-ChIP_HL60_Human1.71216573
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67307230
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65247047
26FOXP3_21729870_ChIP-Seq_TREG_Human1.60399529
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57260570
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57022879
29IGF1R_20145208_ChIP-Seq_DFB_Human1.55527039
30* TP53_22573176_ChIP-Seq_HFKS_Human1.55292423
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.51068942
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50087817
33* NANOG_20526341_ChIP-Seq_ESCs_Human1.47921843
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.46585336
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45713791
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45145702
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.43813979
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38103509
39IRF1_19129219_ChIP-ChIP_H3396_Human1.37181716
40BCL6_27268052_Chip-Seq_Bcells_Human1.35819858
41NCOR_22424771_ChIP-Seq_293T_Human1.33749020
42AR_20517297_ChIP-Seq_VCAP_Human1.32868576
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31527393
44TAF2_19829295_ChIP-Seq_ESCs_Human1.31329322
45GATA3_26560356_Chip-Seq_TH2_Human1.30979762
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.28666565
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.27494965
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27494965
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26342613
50ERA_21632823_ChIP-Seq_H3396_Human1.25943825
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25509636
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25433694
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24942723
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23394676
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.19131947
56MYC_19829295_ChIP-Seq_ESCs_Human1.18911548
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18446859
58MYB_26560356_Chip-Seq_TH2_Human1.18296856
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16875526
60* CTCF_20526341_ChIP-Seq_ESCs_Human1.16682218
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.14074283
62ELK1_19687146_ChIP-ChIP_HELA_Human1.14070068
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12274218
64* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12173911
65EWS_26573619_Chip-Seq_HEK293_Human1.10794918
66P300_27268052_Chip-Seq_Bcells_Human1.09561077
67RUNX_20019798_ChIP-Seq_JUKART_Human1.09043634
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08572274
69P53_21459846_ChIP-Seq_SAOS-2_Human1.08408759
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06973332
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06699531
72GATA3_27048872_Chip-Seq_THYMUS_Human1.06620004
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06096884
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05671892
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.05167214
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04908306
77E2F1_20622854_ChIP-Seq_HELA_Human1.04362673
78ERG_20517297_ChIP-Seq_VCAP_Human1.04193913
79TTF2_22483619_ChIP-Seq_HELA_Human1.03246949
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.02874415
81STAT1_20625510_ChIP-Seq_HELA_Human1.02748302
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00637818
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00043457
84HTT_18923047_ChIP-ChIP_STHdh_Human0.99827681
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.99419173
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99179926
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99144440
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98350732
89CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97983302
90RNF2_27304074_Chip-Seq_NSC_Mouse0.96331253
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96274028
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.96164689
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.96053123
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.95830437
95NANOG_19829295_ChIP-Seq_ESCs_Human0.95136402
96SOX2_19829295_ChIP-Seq_ESCs_Human0.95136402
97ER_23166858_ChIP-Seq_MCF-7_Human0.94964160
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.94963707
99SA1_27219007_Chip-Seq_Bcells_Human0.94718804
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93519327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.04750612
2MP0005671_abnormal_response_to3.84371354
3MP0006292_abnormal_olfactory_placode3.46846221
4MP0004147_increased_porphyrin_level2.92657051
5MP0003646_muscle_fatigue2.80536749
6MP0002102_abnormal_ear_morphology2.68728561
7MP0009333_abnormal_splenocyte_physiolog2.07734132
8MP0002837_dystrophic_cardiac_calcinosis2.06018796
9MP0009785_altered_susceptibility_to1.94941037
10MP0005645_abnormal_hypothalamus_physiol1.93657761
11MP0008872_abnormal_physiological_respon1.90274772
12MP0005646_abnormal_pituitary_gland1.86208923
13MP0006072_abnormal_retinal_apoptosis1.80896047
14MP0001968_abnormal_touch/_nociception1.78941374
15MP0001835_abnormal_antigen_presentation1.75210306
16MP0002163_abnormal_gland_morphology1.74489397
17MP0005551_abnormal_eye_electrophysiolog1.65157245
18MP0001873_stomach_inflammation1.63153314
19MP0001800_abnormal_humoral_immune1.61430495
20MP0001905_abnormal_dopamine_level1.58224055
21MP0002148_abnormal_hypersensitivity_rea1.57993617
22MP0003011_delayed_dark_adaptation1.55419359
23MP0002653_abnormal_ependyma_morphology1.53598969
24MP0004885_abnormal_endolymph1.48538447
25MP0002876_abnormal_thyroid_physiology1.47792582
26MP0004145_abnormal_muscle_electrophysio1.46179344
27MP0005000_abnormal_immune_tolerance1.43895695
28MP0003763_abnormal_thymus_physiology1.42154430
29MP0002723_abnormal_immune_serum1.41569127
30MP0001986_abnormal_taste_sensitivity1.40043340
31MP0005389_reproductive_system_phenotype1.39878605
32MP0008875_abnormal_xenobiotic_pharmacok1.39004060
33MP0002160_abnormal_reproductive_system1.37579649
34MP0005075_abnormal_melanosome_morpholog1.35910609
35MP0001790_abnormal_immune_system1.32428446
36MP0005387_immune_system_phenotype1.32428446
37MP0005084_abnormal_gallbladder_morpholo1.31960057
38MP0005377_hearing/vestibular/ear_phenot1.30987267
39MP0003878_abnormal_ear_physiology1.30987267
40MP0002420_abnormal_adaptive_immunity1.29503742
41MP0000372_irregular_coat_pigmentation1.28716888
42MP0001819_abnormal_immune_cell1.25377528
43MP0004142_abnormal_muscle_tone1.24453544
44MP0000678_abnormal_parathyroid_gland1.21895560
45MP0002234_abnormal_pharynx_morphology1.21683607
46MP0002095_abnormal_skin_pigmentation1.21617061
47MP0006276_abnormal_autonomic_nervous1.19775413
48MP0005025_abnormal_response_to1.18611814
49MP0002638_abnormal_pupillary_reflex1.18201771
50MP0008877_abnormal_DNA_methylation1.16923405
51MP0003195_calcinosis1.14718164
52MP0002736_abnormal_nociception_after1.13035583
53MP0000685_abnormal_immune_system1.12574602
54MP0003806_abnormal_nucleotide_metabolis1.12434389
55MP0001919_abnormal_reproductive_system1.12131944
56MP0005253_abnormal_eye_physiology1.11751120
57MP0000049_abnormal_middle_ear1.11237248
58MP0009764_decreased_sensitivity_to1.07548760
59MP0003866_abnormal_defecation1.06571721
60MP0002452_abnormal_antigen_presenting1.03911421
61MP0002138_abnormal_hepatobiliary_system1.00356651
62MP0000716_abnormal_immune_system0.99581471
63MP0002735_abnormal_chemical_nociception0.97967945
64MP0001764_abnormal_homeostasis0.96836540
65MP0003186_abnormal_redox_activity0.96830015
66MP0005410_abnormal_fertilization0.94385008
67MP0009745_abnormal_behavioral_response0.94247385
68MP0008789_abnormal_olfactory_epithelium0.93315761
69MP0002398_abnormal_bone_marrow0.93215034
70MP0002405_respiratory_system_inflammati0.92344609
71MP0002272_abnormal_nervous_system0.92264558
72MP0003786_premature_aging0.91401640
73MP0003880_abnormal_central_pattern0.90851001
74MP0001485_abnormal_pinna_reflex0.89646621
75MP0008995_early_reproductive_senescence0.88768001
76MP0005379_endocrine/exocrine_gland_phen0.87769556
77MP0004043_abnormal_pH_regulation0.87683226
78MP0000631_abnormal_neuroendocrine_gland0.87064778
79MP0002277_abnormal_respiratory_mucosa0.86652910
80MP0008058_abnormal_DNA_repair0.85563414
81MP0002733_abnormal_thermal_nociception0.85140256
82MP0001845_abnormal_inflammatory_respons0.84896848
83MP0003137_abnormal_impulse_conducting0.83818442
84MP0003787_abnormal_imprinting0.83498918
85MP0001963_abnormal_hearing_physiology0.82822801
86MP0000689_abnormal_spleen_morphology0.82338031
87MP0005360_urolithiasis0.82037399
88MP0001348_abnormal_lacrimal_gland0.81325979
89MP0002933_joint_inflammation0.81089110
90MP0009643_abnormal_urine_homeostasis0.80048393
91MP0005174_abnormal_tail_pigmentation0.79824923
92MP0004742_abnormal_vestibular_system0.79657171
93MP0005636_abnormal_mineral_homeostasis0.79407707
94MP0006036_abnormal_mitochondrial_physio0.79019392
95MP0001970_abnormal_pain_threshold0.78899801
96MP0001663_abnormal_digestive_system0.78820013
97MP0000230_abnormal_systemic_arterial0.78124790
98MP0010155_abnormal_intestine_physiology0.76727559
99MP0008469_abnormal_protein_level0.75681683
100MP0002429_abnormal_blood_cell0.74835187

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.05694705
2Abnormality of cells of the erythroid lineage (HP:0012130)3.98346546
3Acute necrotizing encephalopathy (HP:0006965)3.93511663
4Congenital stationary night blindness (HP:0007642)3.85049160
5Mitochondrial inheritance (HP:0001427)3.80748074
6Reticulocytopenia (HP:0001896)3.66493753
7Abnormal mitochondria in muscle tissue (HP:0008316)3.59068651
8Abnormal number of erythroid precursors (HP:0012131)3.57414379
9Acute encephalopathy (HP:0006846)3.41210499
10Abnormal rod and cone electroretinograms (HP:0008323)3.35451909
11Elevated erythrocyte sedimentation rate (HP:0003565)3.34322304
12Hepatocellular necrosis (HP:0001404)3.31755013
13Pancreatic cysts (HP:0001737)3.25357326
14Increased CSF lactate (HP:0002490)3.25260060
15Aplastic anemia (HP:0001915)3.18987158
16IgG deficiency (HP:0004315)3.17728486
17Severe combined immunodeficiency (HP:0004430)3.15441290
18Progressive macrocephaly (HP:0004481)3.15011466
19Molar tooth sign on MRI (HP:0002419)3.06328546
20Abnormality of midbrain morphology (HP:0002418)3.06328546
21Increased hepatocellular lipid droplets (HP:0006565)3.04945069
22Lipid accumulation in hepatocytes (HP:0006561)3.02921793
23Macrocytic anemia (HP:0001972)2.98140357
24Increased intramyocellular lipid droplets (HP:0012240)2.90894209
25Renal Fanconi syndrome (HP:0001994)2.89005744
26Hepatic necrosis (HP:0002605)2.88329222
273-Methylglutaconic aciduria (HP:0003535)2.81031517
28Pancreatic fibrosis (HP:0100732)2.80351532
29Pallor (HP:0000980)2.73233660
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73153523
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73153523
32True hermaphroditism (HP:0010459)2.71836977
33Optic disc pallor (HP:0000543)2.66698395
34Abolished electroretinogram (ERG) (HP:0000550)2.62808886
35Cerebral edema (HP:0002181)2.61156206
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60768630
37Increased muscle lipid content (HP:0009058)2.60567487
38Hypoproteinemia (HP:0003075)2.48012992
39Pendular nystagmus (HP:0012043)2.46896627
40Microretrognathia (HP:0000308)2.44653659
41Abnormality of B cell number (HP:0010975)2.41576414
42Attenuation of retinal blood vessels (HP:0007843)2.40415977
43Panhypogammaglobulinemia (HP:0003139)2.40296827
44Decreased central vision (HP:0007663)2.39157095
45Thyroiditis (HP:0100646)2.37557243
46T lymphocytopenia (HP:0005403)2.35528014
47Nephronophthisis (HP:0000090)2.34584565
48Increased serum lactate (HP:0002151)2.31848379
49Abnormality of T cell number (HP:0011839)2.29569070
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26992132
51Combined immunodeficiency (HP:0005387)2.25479793
52Absent thumb (HP:0009777)2.24436075
53Type II lissencephaly (HP:0007260)2.24133757
54Increased IgM level (HP:0003496)2.21697046
55Lactic acidosis (HP:0003128)2.21258405
56Stenosis of the external auditory canal (HP:0000402)2.19448237
57Exertional dyspnea (HP:0002875)2.17786097
58Polydipsia (HP:0001959)2.16874055
59Abnormal drinking behavior (HP:0030082)2.16874055
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14428272
61B lymphocytopenia (HP:0010976)2.13904759
62Agammaglobulinemia (HP:0004432)2.13442552
63Abnormality of T cells (HP:0002843)2.11811139
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.09948013
65Abnormal respiratory epithelium morphology (HP:0012253)2.07494118
66Abnormal respiratory motile cilium morphology (HP:0005938)2.07494118
67Abnormality of the renal cortex (HP:0011035)2.06286278
68Asplenia (HP:0001746)2.05145717
69Constricted visual fields (HP:0001133)2.02808887
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.01539281
71Absent/shortened dynein arms (HP:0200106)2.01539281
72Abnormality of the prostate (HP:0008775)2.00990647
73Lethargy (HP:0001254)1.99887758
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98461586
75Abnormality of DNA repair (HP:0003254)1.94947891
76Increased corneal curvature (HP:0100692)1.92949486
77Keratoconus (HP:0000563)1.92949486
78Abnormality of the renal medulla (HP:0100957)1.92754551
79Pancytopenia (HP:0001876)1.92168490
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.91872527
81Medial flaring of the eyebrow (HP:0010747)1.91722300
82Cystic liver disease (HP:0006706)1.89304536
83Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88116336
84Hyperglycinemia (HP:0002154)1.87828201
85Birth length less than 3rd percentile (HP:0003561)1.87633881
86Respiratory failure (HP:0002878)1.86180375
87Autoimmune hemolytic anemia (HP:0001890)1.84517859
88Colon cancer (HP:0003003)1.83697343
89Polyuria (HP:0000103)1.83562545
90Encephalitis (HP:0002383)1.82237917
91Stomatitis (HP:0010280)1.81788325
92Type 2 muscle fiber atrophy (HP:0003554)1.81733498
93Abnormality of renal resorption (HP:0011038)1.81376140
94Abnormal ciliary motility (HP:0012262)1.81360234
95Abnormality of eosinophils (HP:0001879)1.80833670
96Abnormality of urine glucose concentration (HP:0011016)1.79672484
97Glycosuria (HP:0003076)1.79672484
98Chronic hepatic failure (HP:0100626)1.78197580
99Abnormal respiratory motile cilium physiology (HP:0012261)1.77276530
100Exercise intolerance (HP:0003546)1.76610227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.08318328
2BCKDK3.66418222
3KDR3.50991563
4TESK23.32144911
5ADRBK23.22247355
6TLK12.72901495
7MAP4K22.66613529
8PASK2.62125510
9ZAK2.52628485
10GRK12.38926175
11TAOK32.38118673
12WNK42.32413592
13MAP4K12.01785985
14BMPR1B1.98977205
15CDK191.98452338
16STK161.97998800
17VRK21.84547641
18NUAK11.65553320
19TIE11.63228514
20ITK1.50500512
21MUSK1.49570382
22TEC1.49093388
23PINK11.48364764
24CAMKK11.48133451
25DAPK21.46253006
26MAP3K111.27100086
27SYK1.21521690
28FRK1.19913212
29KIT1.16577018
30PRKCQ1.12927052
31VRK11.10657941
32ADRBK11.10327391
33LIMK11.08614182
34NME11.08316845
35IKBKB1.06354143
36FES1.03566918
37STK390.98267285
38INSRR0.96985318
39BTK0.95656764
40SCYL20.94452782
41DYRK20.92545491
42IKBKE0.91624111
43LCK0.89572696
44PIM20.82903287
45GRK60.81985970
46GRK70.81857344
47RPS6KA50.79942213
48FLT30.76656881
49ACVR1B0.76491341
50ABL20.75049429
51MAP2K60.74868625
52CAMKK20.74483303
53NME20.74281366
54WNK30.73419873
55LYN0.72033700
56TNK20.70573436
57LRRK20.69337859
58MAPKAPK30.66447593
59PIK3CA0.66121626
60TGFBR10.66001606
61MAP3K120.65972823
62CSF1R0.62262524
63OBSCN0.60879362
64TBK10.59741998
65PIM10.59164656
66MAPK130.58402166
67OXSR10.57330820
68AURKA0.52555897
69RPS6KA60.52476151
70BUB10.52368522
71PIK3CG0.50811637
72DAPK30.49168736
73PRKACA0.48585450
74CAMK10.47419964
75NEK20.47062494
76DAPK10.44922835
77PRKCA0.44517273
78JAK30.44018577
79CSNK2A20.41212452
80CSNK2A10.40441327
81NEK10.40168676
82CSK0.38876051
83IGF1R0.38776011
84CAMK2A0.38328242
85SIK20.38233663
86TESK10.37676519
87PRKCD0.37586310
88PRKCG0.34730500
89CDK80.34313553
90RPS6KA40.33583108
91MAP2K70.32532462
92ZAP700.31974159
93PRKCH0.31871749
94MYLK0.30542891
95RPS6KB20.28436957
96CSNK1A10.26821285
97RPS6KC10.25782493
98RPS6KL10.25782493
99MAP2K20.25291428
100ABL10.25206633

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.50846258
2Primary immunodeficiency_Homo sapiens_hsa053403.71262073
3Oxidative phosphorylation_Homo sapiens_hsa001903.45310507
4Parkinsons disease_Homo sapiens_hsa050122.81080396
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53928651
6Proteasome_Homo sapiens_hsa030502.51233581
7Allograft rejection_Homo sapiens_hsa053302.16218538
8Linoleic acid metabolism_Homo sapiens_hsa005912.13690589
9Graft-versus-host disease_Homo sapiens_hsa053322.09255998
10Autoimmune thyroid disease_Homo sapiens_hsa053202.08016734
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03740791
12RNA polymerase_Homo sapiens_hsa030202.01753793
13Phototransduction_Homo sapiens_hsa047441.97112112
14Asthma_Homo sapiens_hsa053101.92224373
15Alzheimers disease_Homo sapiens_hsa050101.88253243
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87190145
17Huntingtons disease_Homo sapiens_hsa050161.81787254
18Sulfur relay system_Homo sapiens_hsa041221.80724037
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.78622298
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77979976
21Cardiac muscle contraction_Homo sapiens_hsa042601.67027216
22Type I diabetes mellitus_Homo sapiens_hsa049401.66615081
23Antigen processing and presentation_Homo sapiens_hsa046121.62732457
24Hematopoietic cell lineage_Homo sapiens_hsa046401.62395784
25Homologous recombination_Homo sapiens_hsa034401.38828142
26Nitrogen metabolism_Homo sapiens_hsa009101.37292331
27Protein export_Homo sapiens_hsa030601.34141600
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31001367
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23179068
30Pyrimidine metabolism_Homo sapiens_hsa002401.17208419
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13673826
32RNA degradation_Homo sapiens_hsa030181.11272108
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10283846
34Rheumatoid arthritis_Homo sapiens_hsa053231.09806161
35One carbon pool by folate_Homo sapiens_hsa006701.06966498
36Arachidonic acid metabolism_Homo sapiens_hsa005901.05750864
37Caffeine metabolism_Homo sapiens_hsa002321.05527557
38Olfactory transduction_Homo sapiens_hsa047401.01852852
39Peroxisome_Homo sapiens_hsa041461.01370626
40Ether lipid metabolism_Homo sapiens_hsa005651.00502448
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97787704
42Chemical carcinogenesis_Homo sapiens_hsa052040.93531112
43Fanconi anemia pathway_Homo sapiens_hsa034600.92277696
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.91654791
45Butanoate metabolism_Homo sapiens_hsa006500.91317967
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89309543
47Retinol metabolism_Homo sapiens_hsa008300.88995342
48T cell receptor signaling pathway_Homo sapiens_hsa046600.87243209
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86947100
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86818878
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85262194
52Basal transcription factors_Homo sapiens_hsa030220.83159240
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82442541
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80521373
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78799625
56Nucleotide excision repair_Homo sapiens_hsa034200.77807661
57Base excision repair_Homo sapiens_hsa034100.77732183
58Purine metabolism_Homo sapiens_hsa002300.76638246
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74944822
60Fat digestion and absorption_Homo sapiens_hsa049750.74726615
61Propanoate metabolism_Homo sapiens_hsa006400.73088522
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.70728288
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.69924200
64Nicotine addiction_Homo sapiens_hsa050330.69595903
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68172627
66Tryptophan metabolism_Homo sapiens_hsa003800.67996836
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67837092
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64728569
69DNA replication_Homo sapiens_hsa030300.62597020
70Metabolic pathways_Homo sapiens_hsa011000.61328667
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60095651
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.57010996
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.54827074
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53900561
75Mismatch repair_Homo sapiens_hsa034300.49149579
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45716788
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44345135
78Malaria_Homo sapiens_hsa051440.43640995
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43553191
80Taste transduction_Homo sapiens_hsa047420.43168463
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.42057413
82Systemic lupus erythematosus_Homo sapiens_hsa053220.41683988
83Viral myocarditis_Homo sapiens_hsa054160.41267750
84Spliceosome_Homo sapiens_hsa030400.39761184
85Morphine addiction_Homo sapiens_hsa050320.39401002
86Collecting duct acid secretion_Homo sapiens_hsa049660.39298572
87Ovarian steroidogenesis_Homo sapiens_hsa049130.37503426
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37354732
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35875421
90Sulfur metabolism_Homo sapiens_hsa009200.35664872
91Tyrosine metabolism_Homo sapiens_hsa003500.35260324
92Regulation of autophagy_Homo sapiens_hsa041400.33499139
93RNA transport_Homo sapiens_hsa030130.32871759
94Measles_Homo sapiens_hsa051620.32716728
95Salivary secretion_Homo sapiens_hsa049700.32377799
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30398646
97Serotonergic synapse_Homo sapiens_hsa047260.29766742
98Staphylococcus aureus infection_Homo sapiens_hsa051500.28961725
99ABC transporters_Homo sapiens_hsa020100.27945835
100Selenocompound metabolism_Homo sapiens_hsa004500.27846139

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