RPL13AP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)6.42336133
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.79590316
3DNA deamination (GO:0045006)5.36877468
4somite development (GO:0061053)5.14155917
5axoneme assembly (GO:0035082)5.08167623
6regulation of cilium movement (GO:0003352)4.99656588
7epithelial cilium movement (GO:0003351)4.79686503
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.76941067
9chemical homeostasis within a tissue (GO:0048875)4.76679861
10protein polyglutamylation (GO:0018095)4.69839294
11cilium movement (GO:0003341)4.64906686
12axonemal dynein complex assembly (GO:0070286)4.52236583
13cilium or flagellum-dependent cell motility (GO:0001539)4.48572671
14response to pheromone (GO:0019236)4.24689231
15positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.19251873
16regulation of memory T cell differentiation (GO:0043380)4.12125547
17adaptation of signaling pathway (GO:0023058)4.02666666
18retinal cone cell development (GO:0046549)4.01777639
19nonmotile primary cilium assembly (GO:0035058)3.91014810
20cellular response to exogenous dsRNA (GO:0071360)3.90701089
21motile cilium assembly (GO:0044458)3.84694310
22production of molecular mediator involved in inflammatory response (GO:0002532)3.83295201
23reflex (GO:0060004)3.60569103
24activated T cell proliferation (GO:0050798)3.50152375
25striatum development (GO:0021756)3.40887807
26one-carbon compound transport (GO:0019755)3.38699958
27positive T cell selection (GO:0043368)3.38096874
28regulation of vasculogenesis (GO:2001212)3.36526939
29glycosphingolipid biosynthetic process (GO:0006688)3.32651590
30cellular response to nitric oxide (GO:0071732)3.29990592
31leukotriene biosynthetic process (GO:0019370)3.24464992
32phosphatidylinositol acyl-chain remodeling (GO:0036149)3.22267517
33phosphatidylserine acyl-chain remodeling (GO:0036150)3.18408132
34lipoxygenase pathway (GO:0019372)3.18196492
35positive regulation of defense response to virus by host (GO:0002230)3.17125436
36regulation of microtubule-based movement (GO:0060632)3.16255268
37water-soluble vitamin biosynthetic process (GO:0042364)3.14674881
38positive regulation of T cell cytokine production (GO:0002726)3.14233386
39phosphatidylcholine acyl-chain remodeling (GO:0036151)3.13912402
40phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.13692595
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09078751
42left/right axis specification (GO:0070986)3.06096224
43cytidine deamination (GO:0009972)3.05170630
44cytidine metabolic process (GO:0046087)3.05170630
45cytidine catabolic process (GO:0006216)3.05170630
46neuronal action potential propagation (GO:0019227)3.04693463
47regulation of immunoglobulin secretion (GO:0051023)2.98484913
48kidney morphogenesis (GO:0060993)2.97357240
49rRNA modification (GO:0000154)2.95453806
50negative regulation of alpha-beta T cell differentiation (GO:0046639)2.94683951
51regulation of regulatory T cell differentiation (GO:0045589)2.94399037
52detection of light stimulus involved in visual perception (GO:0050908)2.94324899
53detection of light stimulus involved in sensory perception (GO:0050962)2.94324899
54cellular response to interferon-beta (GO:0035458)2.93911162
55negative T cell selection (GO:0043383)2.92938981
56preassembly of GPI anchor in ER membrane (GO:0016254)2.90862660
57NAD biosynthetic process (GO:0009435)2.88479136
58urate metabolic process (GO:0046415)2.86296248
59response to gravity (GO:0009629)2.84694131
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80324999
61positive regulation of vasculogenesis (GO:2001214)2.80301828
62indolalkylamine metabolic process (GO:0006586)2.78715262
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.78136755
64GPI anchor metabolic process (GO:0006505)2.77229231
65pyrimidine nucleobase catabolic process (GO:0006208)2.71691778
66negative regulation of appetite (GO:0032099)2.71271886
67negative regulation of response to food (GO:0032096)2.71271886
68positive regulation of T cell differentiation in thymus (GO:0033089)2.69149577
69valine metabolic process (GO:0006573)2.68838295
70positive regulation of phosphatase activity (GO:0010922)2.68159081
71cilium morphogenesis (GO:0060271)2.67340742
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.67034780
73regulation of appetite (GO:0032098)2.61212210
74respiratory gaseous exchange (GO:0007585)2.60780781
75tryptophan catabolic process (GO:0006569)2.58715696
76indole-containing compound catabolic process (GO:0042436)2.58715696
77indolalkylamine catabolic process (GO:0046218)2.58715696
78cellular response to leptin stimulus (GO:0044320)2.58121302
79response to interferon-beta (GO:0035456)2.57619725
80ATP synthesis coupled proton transport (GO:0015986)2.56591726
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56591726
82sodium ion homeostasis (GO:0055078)2.55658141
83negative regulation of mast cell activation (GO:0033004)2.53624950
84cilium organization (GO:0044782)2.52167343
85glycolipid biosynthetic process (GO:0009247)2.51911460
86arachidonic acid secretion (GO:0050482)2.50980753
87icosanoid secretion (GO:0032309)2.50980753
88thalamus development (GO:0021794)2.49023109
89protein homotrimerization (GO:0070207)2.48381928
90cellular ketone body metabolic process (GO:0046950)2.48308456
91organelle membrane fusion (GO:0090174)2.48223154
92positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.47828629
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.47492004
94cellular response to reactive nitrogen species (GO:1902170)2.47355556
95negative regulation of T-helper cell differentiation (GO:0045623)2.47031501
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.47031501
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.46554862
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46233088
99regulation of response to food (GO:0032095)2.42531035
100regulation of defense response to virus by host (GO:0050691)2.42493141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.49028489
2VDR_22108803_ChIP-Seq_LS180_Human4.14870392
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17223771
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.97100594
5EZH2_22144423_ChIP-Seq_EOC_Human2.74051727
6ZNF274_21170338_ChIP-Seq_K562_Hela2.54840058
7IGF1R_20145208_ChIP-Seq_DFB_Human2.53739820
8GBX2_23144817_ChIP-Seq_PC3_Human2.50134634
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40769253
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36828241
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08135587
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.06094213
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00142964
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97236484
15TAF15_26573619_Chip-Seq_HEK293_Human1.89621204
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89172570
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87245294
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84198828
19CBP_20019798_ChIP-Seq_JUKART_Human1.81027811
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.81027811
21* ER_23166858_ChIP-Seq_MCF-7_Human1.78582671
22P300_19829295_ChIP-Seq_ESCs_Human1.77965226
23EWS_26573619_Chip-Seq_HEK293_Human1.74905532
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68691376
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64823168
26AR_21572438_ChIP-Seq_LNCaP_Human1.60428633
27FUS_26573619_Chip-Seq_HEK293_Human1.60023833
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59630764
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58358574
30TCF4_22108803_ChIP-Seq_LS180_Human1.53118325
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.52686014
32SMAD4_21799915_ChIP-Seq_A2780_Human1.52255523
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50990082
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49469432
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48129800
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48036358
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46705905
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41704930
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37408629
40STAT3_23295773_ChIP-Seq_U87_Human1.36513171
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35854757
42TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33651272
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28964965
44AR_20517297_ChIP-Seq_VCAP_Human1.25482665
45BCAT_22108803_ChIP-Seq_LS180_Human1.24637142
46AR_25329375_ChIP-Seq_VCAP_Human1.24544784
47TCF4_23295773_ChIP-Seq_U87_Human1.24529723
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24351833
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23851395
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23145006
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22292325
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.22178422
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.22142640
54TP53_22573176_ChIP-Seq_HFKS_Human1.21116232
55GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20685444
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18071412
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.17804065
58SOX2_19829295_ChIP-Seq_ESCs_Human1.17479436
59NANOG_19829295_ChIP-Seq_ESCs_Human1.17479436
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.16531650
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15878323
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.15018973
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14132340
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12763533
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12529419
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.12529419
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12417640
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12245801
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11173696
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.10704508
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09378642
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08776045
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.08582622
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08143000
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.07925357
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06797581
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06545876
78DROSHA_22980978_ChIP-Seq_HELA_Human1.06408790
79IRF1_19129219_ChIP-ChIP_H3396_Human1.06349354
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06210394
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05245272
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04244204
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02807042
84OCT4_20526341_ChIP-Seq_ESCs_Human1.01714248
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.00350656
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.99539246
87* SMAD3_21741376_ChIP-Seq_EPCs_Human0.99327861
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.98428190
89CDX2_22108803_ChIP-Seq_LS180_Human0.98303249
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98065733
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97848573
92* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97456925
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96601895
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96487027
95P53_22387025_ChIP-Seq_ESCs_Mouse0.95884996
96NCOR_22424771_ChIP-Seq_293T_Human0.93488103
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.93487198
98TAF2_19829295_ChIP-Seq_ESCs_Human0.93358610
99HOXB7_26014856_ChIP-Seq_BT474_Human0.92989205
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.92372263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog3.70457206
2MP0008995_early_reproductive_senescence3.25335966
3MP0001986_abnormal_taste_sensitivity3.24421582
4MP0003950_abnormal_plasma_membrane2.74232957
5MP0001984_abnormal_olfaction2.64570564
6MP0003724_increased_susceptibility_to2.63939024
7MP0001968_abnormal_touch/_nociception2.58919648
8MP0005671_abnormal_response_to2.56955530
9MP0005423_abnormal_somatic_nervous2.48570510
10MP0002736_abnormal_nociception_after2.46063915
11MP0005551_abnormal_eye_electrophysiolog2.25620380
12MP0002254_reproductive_system_inflammat2.22984768
13MP0001958_emphysema2.12071288
14MP0001486_abnormal_startle_reflex2.07736128
15MP0003195_calcinosis1.98064586
16MP0002653_abnormal_ependyma_morphology1.95385633
17MP0008058_abnormal_DNA_repair1.94553927
18MP0002102_abnormal_ear_morphology1.91016942
19MP0005646_abnormal_pituitary_gland1.88819576
20MP0005253_abnormal_eye_physiology1.80998020
21MP0001501_abnormal_sleep_pattern1.76642992
22MP0006292_abnormal_olfactory_placode1.71043507
23MP0003436_decreased_susceptibility_to1.66457147
24MP0002234_abnormal_pharynx_morphology1.65488167
25MP0002876_abnormal_thyroid_physiology1.60521021
26MP0004145_abnormal_muscle_electrophysio1.53560899
27MP0000613_abnormal_salivary_gland1.52247707
28MP0002090_abnormal_vision1.51751274
29MP0009379_abnormal_foot_pigmentation1.51498862
30MP0005084_abnormal_gallbladder_morpholo1.50446844
31MP0002148_abnormal_hypersensitivity_rea1.47553023
32MP0002733_abnormal_thermal_nociception1.46351352
33MP0001440_abnormal_grooming_behavior1.45290444
34MP0000569_abnormal_digit_pigmentation1.45214144
35MP0001542_abnormal_bone_strength1.37036081
36MP0001970_abnormal_pain_threshold1.36681591
37MP0003866_abnormal_defecation1.34916697
38MP0001790_abnormal_immune_system1.32386360
39MP0005387_immune_system_phenotype1.32386360
40MP0002272_abnormal_nervous_system1.30047665
41MP0009053_abnormal_anal_canal1.29706171
42MP0005085_abnormal_gallbladder_physiolo1.26263437
43MP0005636_abnormal_mineral_homeostasis1.21379855
44MP0002282_abnormal_trachea_morphology1.19497244
45MP0009785_altered_susceptibility_to1.19377278
46MP0008789_abnormal_olfactory_epithelium1.19267385
47MP0005647_abnormal_sex_gland1.17868155
48MP0003283_abnormal_digestive_organ1.17079859
49MP0008004_abnormal_stomach_pH1.15266487
50MP0004885_abnormal_endolymph1.15180662
51MP0001346_abnormal_lacrimal_gland1.13744469
52MP0005332_abnormal_amino_acid1.13606830
53MP0001502_abnormal_circadian_rhythm1.13352754
54MP0005195_abnormal_posterior_eye1.10615872
55MP0002166_altered_tumor_susceptibility1.10290587
56MP0002734_abnormal_mechanical_nocicepti1.09337961
57MP0002572_abnormal_emotion/affect_behav1.08994312
58MP0001529_abnormal_vocalization1.06630258
59MP0001835_abnormal_antigen_presentation1.05703970
60MP0003137_abnormal_impulse_conducting1.02933682
61MP0005310_abnormal_salivary_gland1.02589220
62MP0001905_abnormal_dopamine_level1.01732284
63MP0000685_abnormal_immune_system1.00343185
64MP0002095_abnormal_skin_pigmentation0.99309143
65MP0002006_tumorigenesis0.97630819
66MP0005174_abnormal_tail_pigmentation0.96084895
67MP0005388_respiratory_system_phenotype0.94707709
68MP0002133_abnormal_respiratory_system0.94707709
69MP0002138_abnormal_hepatobiliary_system0.93023814
70MP0006072_abnormal_retinal_apoptosis0.92873842
71MP0001853_heart_inflammation0.92124233
72MP0002557_abnormal_social/conspecific_i0.90600858
73MP0005360_urolithiasis0.88943920
74MP0004142_abnormal_muscle_tone0.87931185
75MP0009643_abnormal_urine_homeostasis0.87744663
76MP0000631_abnormal_neuroendocrine_gland0.87672418
77MP0002168_other_aberrant_phenotype0.87605505
78MP0000639_abnormal_adrenal_gland0.85902846
79MP0009046_muscle_twitch0.83824228
80MP0010329_abnormal_lipoprotein_level0.83292336
81MP0002064_seizures0.83066523
82MP0003786_premature_aging0.82404735
83MP0000372_irregular_coat_pigmentation0.79018955
84MP0005167_abnormal_blood-brain_barrier0.77775627
85MP0010368_abnormal_lymphatic_system0.77709630
86MP0003136_yellow_coat_color0.77264809
87MP0001765_abnormal_ion_homeostasis0.76640156
88MP0003878_abnormal_ear_physiology0.75433764
89MP0005377_hearing/vestibular/ear_phenot0.75433764
90MP0001293_anophthalmia0.75345379
91MP0001664_abnormal_digestion0.74809352
92MP0002405_respiratory_system_inflammati0.74182425
93MP0000427_abnormal_hair_cycle0.74021571
94MP0003045_fibrosis0.73049632
95MP0009745_abnormal_behavioral_response0.72179052
96MP0001533_abnormal_skeleton_physiology0.70411198
97MP0005000_abnormal_immune_tolerance0.69379125
98MP0002067_abnormal_sensory_capabilities0.68667074
99MP0004043_abnormal_pH_regulation0.68490837
100MP0002063_abnormal_learning/memory/cond0.66882664

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.67321835
2Absent/shortened dynein arms (HP:0200106)5.67321835
3Interstitial pulmonary disease (HP:0006530)4.85875574
4Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.77659139
5Visual hallucinations (HP:0002367)4.44200113
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.43849416
7Abnormal respiratory motile cilium morphology (HP:0005938)4.21343262
8Abnormal respiratory epithelium morphology (HP:0012253)4.21343262
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.19089805
10Abnormal ciliary motility (HP:0012262)4.14403838
11Chronic bronchitis (HP:0004469)4.09717396
12Prostate neoplasm (HP:0100787)3.85679007
13Abnormal respiratory motile cilium physiology (HP:0012261)3.70397446
14Increased cerebral lipofuscin (HP:0011813)3.48567685
15Testicular atrophy (HP:0000029)3.38733554
16Tachypnea (HP:0002789)3.37652154
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34461304
18Tubulointerstitial fibrosis (HP:0005576)3.31142717
19Medial flaring of the eyebrow (HP:0010747)3.30973247
20Autoimmune thrombocytopenia (HP:0001973)3.21979049
21Abnormality of the renal cortex (HP:0011035)3.17167974
22Elevated erythrocyte sedimentation rate (HP:0003565)3.17041203
23Methylmalonic acidemia (HP:0002912)3.08354295
24Abnormal rod and cone electroretinograms (HP:0008323)3.02411844
25Renal cortical cysts (HP:0000803)2.94605943
26Exertional dyspnea (HP:0002875)2.91426552
27Abnormality of midbrain morphology (HP:0002418)2.89169643
28Molar tooth sign on MRI (HP:0002419)2.89169643
29Pancreatic cysts (HP:0001737)2.87014630
30Alveolar cell carcinoma (HP:0006519)2.86819351
31Asplenia (HP:0001746)2.84654962
32Abnormality of the prostate (HP:0008775)2.81512865
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.80763801
34Tubulointerstitial abnormality (HP:0001969)2.79927656
35Rhinitis (HP:0012384)2.78070586
36Congenital stationary night blindness (HP:0007642)2.69007751
37Pancreatic fibrosis (HP:0100732)2.67163707
38Nephronophthisis (HP:0000090)2.64238040
39Abolished electroretinogram (ERG) (HP:0000550)2.52361154
40Autoimmune hemolytic anemia (HP:0001890)2.48633184
41Decreased circulating renin level (HP:0003351)2.47018922
42Abnormal drinking behavior (HP:0030082)2.44044372
43Polydipsia (HP:0001959)2.44044372
44True hermaphroditism (HP:0010459)2.42571341
45Neoplasm of the tracheobronchial system (HP:0100552)2.41472726
46Tubulointerstitial nephritis (HP:0001970)2.31754609
47Abnormality of the renal medulla (HP:0100957)2.28774609
483-Methylglutaconic aciduria (HP:0003535)2.26054391
49Bronchiectasis (HP:0002110)2.24106289
50Tubular atrophy (HP:0000092)2.23270653
51Abnormality of the vitamin B12 metabolism (HP:0004341)2.20478117
52Hypoplasia of the fovea (HP:0007750)2.18685934
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.18685934
54Pulmonary fibrosis (HP:0002206)2.18033517
55Congenital primary aphakia (HP:0007707)2.14375347
56Hypoproteinemia (HP:0003075)2.13194882
57Focal motor seizures (HP:0011153)2.09889835
58Gait imbalance (HP:0002141)2.09112846
59Adactyly (HP:0009776)2.08648286
60Spastic diplegia (HP:0001264)2.07344196
61Respiratory distress (HP:0002098)2.07185064
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06388275
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06388275
64Bronchitis (HP:0012387)2.05825442
65Hemiparesis (HP:0001269)2.03073407
66Hyperactive renin-angiotensin system (HP:0000841)1.99883395
67Abnormality of vitamin B metabolism (HP:0004340)1.98456679
68Nephrogenic diabetes insipidus (HP:0009806)1.97546368
69Insidious onset (HP:0003587)1.96766476
70Termporal pattern (HP:0011008)1.96766476
71Chronic hepatic failure (HP:0100626)1.95527703
72Opisthotonus (HP:0002179)1.90548222
73Systemic lupus erythematosus (HP:0002725)1.87808659
74Panhypogammaglobulinemia (HP:0003139)1.87798959
75Acute necrotizing encephalopathy (HP:0006965)1.86338461
76Methylmalonic aciduria (HP:0012120)1.84732687
77Abnormality of purine metabolism (HP:0004352)1.84054436
78Abnormality of the fovea (HP:0000493)1.82043098
79Attenuation of retinal blood vessels (HP:0007843)1.81982050
80Abnormal number of erythroid precursors (HP:0012131)1.81937056
81Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81879231
82Central scotoma (HP:0000603)1.81768713
83Renal salt wasting (HP:0000127)1.80949614
84Polyuria (HP:0000103)1.78478495
85Abnormality of alanine metabolism (HP:0010916)1.78132692
86Hyperalaninemia (HP:0003348)1.78132692
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78132692
88Abnormality of the fingertips (HP:0001211)1.77182007
89Parakeratosis (HP:0001036)1.76569526
90Cystic liver disease (HP:0006706)1.76508891
91Constricted visual fields (HP:0001133)1.73831081
92Abnormality of renin-angiotensin system (HP:0000847)1.72253111
93Thyroiditis (HP:0100646)1.72073101
94Bony spicule pigmentary retinopathy (HP:0007737)1.70250600
95Dyschromatopsia (HP:0007641)1.67596447
96Papilledema (HP:0001085)1.67205757
97Abnormality of T cell physiology (HP:0011840)1.66954163
98Abnormality of cells of the erythroid lineage (HP:0012130)1.66363731
99Pheochromocytoma (HP:0002666)1.65138843
100Optic disc pallor (HP:0000543)1.61992330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.44856476
2FRK3.79115019
3MAP4K23.34373412
4TLK13.21250059
5EPHA33.06151955
6MST42.57044401
7TIE12.03003876
8DAPK22.01380563
9PINK12.00625582
10MAP4K11.75569129
11MKNK11.75445673
12MAPK151.64652419
13FES1.55113979
14GRK11.53008568
15NEK11.52829261
16EPHB21.51796332
17PKN21.51319260
18AKT31.49922010
19BMPR21.49718973
20ADRBK21.47442508
21BCKDK1.45471867
22MAPKAPK31.43312368
23NUAK11.37515725
24MYLK1.36419520
25ZAK1.35307933
26WNK31.32939143
27TAOK31.28434726
28IKBKB1.20847893
29RPS6KA51.19411636
30WEE11.12246179
31JAK11.11244607
32BMPR1B1.10256742
33MAPK131.05094731
34STK241.04098917
35PNCK1.01367020
36GRK70.93234616
37PAK30.92513546
38PIK3CA0.92396074
39MAPKAPK50.91983676
40DAPK10.89533705
41CASK0.89483819
42PRKCG0.85980389
43INSRR0.85894511
44CAMK2A0.85055252
45CSNK1A1L0.84901883
46TBK10.81473200
47PRKCQ0.80294198
48ZAP700.80041622
49WNK40.79061993
50KIT0.78236029
51FLT30.77107827
52GRK50.76901704
53CHUK0.76800039
54CAMK2G0.74245789
55PRKCE0.73752828
56SRPK10.70910574
57TGFBR10.69055742
58ERBB20.68483519
59TRIM280.66164072
60LYN0.65772000
61STK38L0.64603530
62CAMK2D0.63040020
63CSNK1G30.59418396
64CSNK1G20.58893756
65LRRK20.58034681
66CAMKK20.57463743
67ADRBK10.56619769
68PTK2B0.56238573
69TGFBR20.55810579
70BCR0.54720903
71JAK20.54306998
72TNK20.53559259
73PRKCA0.53289823
74DYRK20.53091838
75SYK0.51974067
76PRKACA0.51856299
77MAP3K120.51224725
78PRKCI0.50028146
79CSNK1G10.49874520
80NME20.49194700
81STK160.48691570
82KDR0.48264370
83PRKACB0.47330187
84IGF1R0.46350778
85FER0.46104687
86IRAK10.44324400
87CSNK2A10.44269217
88ERBB30.44194831
89SGK20.43854221
90SGK10.41969344
91BRSK20.41604329
92EGFR0.41526862
93CSNK1A10.40714916
94AURKA0.40552838
95MAPK70.40265789
96GSK3A0.39696938
97TEC0.38456461
98SRC0.37731703
99CSK0.36800814
100TYK20.36427235

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.04067632
2Asthma_Homo sapiens_hsa053103.03175090
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.00152353
4Graft-versus-host disease_Homo sapiens_hsa053322.75545524
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.45846074
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36358294
7Phototransduction_Homo sapiens_hsa047442.32406193
8Allograft rejection_Homo sapiens_hsa053302.27640570
9Antigen processing and presentation_Homo sapiens_hsa046122.23522953
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.22133139
11Type I diabetes mellitus_Homo sapiens_hsa049402.16290124
12Autoimmune thyroid disease_Homo sapiens_hsa053202.00025686
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88977436
14Oxidative phosphorylation_Homo sapiens_hsa001901.76219044
15Ether lipid metabolism_Homo sapiens_hsa005651.72711282
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70432523
17Histidine metabolism_Homo sapiens_hsa003401.70029190
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67651942
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66670368
20Nicotine addiction_Homo sapiens_hsa050331.60483517
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58473561
22Tryptophan metabolism_Homo sapiens_hsa003801.51541490
23Mineral absorption_Homo sapiens_hsa049781.49450727
24Protein export_Homo sapiens_hsa030601.46601719
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45204039
26Staphylococcus aureus infection_Homo sapiens_hsa051501.38724763
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37506058
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34078906
29Taste transduction_Homo sapiens_hsa047421.32998110
30Ribosome_Homo sapiens_hsa030101.30710207
31Primary immunodeficiency_Homo sapiens_hsa053401.28779044
32Rheumatoid arthritis_Homo sapiens_hsa053231.25714987
33Arachidonic acid metabolism_Homo sapiens_hsa005901.22851499
34Propanoate metabolism_Homo sapiens_hsa006401.21907737
35beta-Alanine metabolism_Homo sapiens_hsa004101.20768606
36Chemical carcinogenesis_Homo sapiens_hsa052041.17776612
37Cardiac muscle contraction_Homo sapiens_hsa042601.14895563
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13318085
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.12181819
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11116288
41ABC transporters_Homo sapiens_hsa020101.04254901
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.01899521
43Ovarian steroidogenesis_Homo sapiens_hsa049131.01825283
44Parkinsons disease_Homo sapiens_hsa050121.00299419
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99850517
46Pertussis_Homo sapiens_hsa051330.97905475
47Huntingtons disease_Homo sapiens_hsa050160.96555383
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93261050
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92998500
50Butanoate metabolism_Homo sapiens_hsa006500.92703580
51Salivary secretion_Homo sapiens_hsa049700.92483523
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90793261
53Regulation of autophagy_Homo sapiens_hsa041400.90115176
54Serotonergic synapse_Homo sapiens_hsa047260.88082121
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87801669
56Nitrogen metabolism_Homo sapiens_hsa009100.85846933
57Basal transcription factors_Homo sapiens_hsa030220.83257165
58RNA degradation_Homo sapiens_hsa030180.81449551
59RNA polymerase_Homo sapiens_hsa030200.80007207
60Fanconi anemia pathway_Homo sapiens_hsa034600.77788268
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74902647
62Retinol metabolism_Homo sapiens_hsa008300.72437296
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.72049225
64Hematopoietic cell lineage_Homo sapiens_hsa046400.71515042
65Morphine addiction_Homo sapiens_hsa050320.71469615
66Alzheimers disease_Homo sapiens_hsa050100.71369885
67Renin secretion_Homo sapiens_hsa049240.68052312
68Tyrosine metabolism_Homo sapiens_hsa003500.67806466
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.66370784
70Systemic lupus erythematosus_Homo sapiens_hsa053220.65726549
71GABAergic synapse_Homo sapiens_hsa047270.64646773
72Olfactory transduction_Homo sapiens_hsa047400.64112168
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.63653243
74Proteasome_Homo sapiens_hsa030500.63608751
75Circadian entrainment_Homo sapiens_hsa047130.63594666
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63533052
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62827949
78Homologous recombination_Homo sapiens_hsa034400.58935775
79Caffeine metabolism_Homo sapiens_hsa002320.58750219
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58357183
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58229930
82Selenocompound metabolism_Homo sapiens_hsa004500.55672294
83Glutamatergic synapse_Homo sapiens_hsa047240.53939210
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49510511
85Phagosome_Homo sapiens_hsa041450.47565811
86Viral myocarditis_Homo sapiens_hsa054160.46070520
87Phenylalanine metabolism_Homo sapiens_hsa003600.46050820
88Herpes simplex infection_Homo sapiens_hsa051680.45135122
89Steroid biosynthesis_Homo sapiens_hsa001000.44304562
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43446623
91Insulin secretion_Homo sapiens_hsa049110.42499909
92Fatty acid degradation_Homo sapiens_hsa000710.42217759
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41801756
94One carbon pool by folate_Homo sapiens_hsa006700.41557122
95Dorso-ventral axis formation_Homo sapiens_hsa043200.39820826
96Amphetamine addiction_Homo sapiens_hsa050310.39456725
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38217738
98Oxytocin signaling pathway_Homo sapiens_hsa049210.37415607
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36802664
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35121908

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