RPL12P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.89446806
2viral transcription (GO:0019083)7.40758851
3translational termination (GO:0006415)7.21551578
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.29181740
5cotranslational protein targeting to membrane (GO:0006613)6.23052309
6protein targeting to ER (GO:0045047)6.15790147
7translational elongation (GO:0006414)6.03449120
8establishment of protein localization to endoplasmic reticulum (GO:0072599)5.90815415
9maturation of SSU-rRNA (GO:0030490)5.90139308
10protein localization to endoplasmic reticulum (GO:0070972)5.84140588
11ribosomal small subunit biogenesis (GO:0042274)5.76881978
12fucose catabolic process (GO:0019317)5.62099096
13L-fucose metabolic process (GO:0042354)5.62099096
14L-fucose catabolic process (GO:0042355)5.62099096
15cellular protein complex disassembly (GO:0043624)5.40065662
16viral life cycle (GO:0019058)5.22140799
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.14873245
18translational initiation (GO:0006413)4.88166778
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.77388892
20NADH dehydrogenase complex assembly (GO:0010257)4.77388892
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.77388892
22adenosine metabolic process (GO:0046085)4.68394035
23water-soluble vitamin biosynthetic process (GO:0042364)4.65181775
24ribosomal large subunit biogenesis (GO:0042273)4.54909689
25protein complex disassembly (GO:0043241)4.53808310
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38145658
27macromolecular complex disassembly (GO:0032984)4.37542318
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.28856926
29ATP synthesis coupled proton transport (GO:0015986)4.28856926
30protein complex biogenesis (GO:0070271)4.21771149
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13049458
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.11843676
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.11843676
34protein targeting to membrane (GO:0006612)4.11641115
35DNA damage response, detection of DNA damage (GO:0042769)4.08696237
36translation (GO:0006412)4.05980589
37mitochondrial respiratory chain complex assembly (GO:0033108)3.81633298
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.73971210
39respiratory electron transport chain (GO:0022904)3.69438981
40electron transport chain (GO:0022900)3.64826210
41proteasome assembly (GO:0043248)3.60399019
42behavioral response to nicotine (GO:0035095)3.58504922
43mRNA catabolic process (GO:0006402)3.51215505
44cellular component biogenesis (GO:0044085)3.50090987
45ribonucleoprotein complex biogenesis (GO:0022613)3.48492210
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.47477458
47DNA deamination (GO:0045006)3.37992679
48regulation of meiosis I (GO:0060631)3.33027989
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31010447
50negative regulation of appetite (GO:0032099)3.29012194
51negative regulation of response to food (GO:0032096)3.29012194
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26366458
53artery development (GO:0060840)3.24741415
54GTP biosynthetic process (GO:0006183)3.19221621
55RNA catabolic process (GO:0006401)3.17615644
56regulation of sequestering of triglyceride (GO:0010889)3.13905801
57chaperone-mediated protein transport (GO:0072321)3.13467869
58folic acid-containing compound biosynthetic process (GO:0009396)3.12335740
59inner mitochondrial membrane organization (GO:0007007)3.10613425
60purine nucleotide salvage (GO:0032261)3.09732809
61negative regulation of DNA biosynthetic process (GO:2000279)3.09388672
62negative regulation of telomerase activity (GO:0051974)3.05397249
63lateral sprouting from an epithelium (GO:0060601)3.01529976
64spliceosomal complex assembly (GO:0000245)2.96017002
65positive regulation of fatty acid transport (GO:2000193)2.93665282
66positive regulation of prostaglandin secretion (GO:0032308)2.90531254
67otic vesicle formation (GO:0030916)2.88467698
68somite development (GO:0061053)2.88146467
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.87702363
70ncRNA 3-end processing (GO:0043628)2.87139682
71tRNA modification (GO:0006400)2.86913794
72resolution of meiotic recombination intermediates (GO:0000712)2.86058909
73rRNA processing (GO:0006364)2.85549162
74tRNA processing (GO:0008033)2.81394468
75rRNA metabolic process (GO:0016072)2.81389575
76negative regulation of telomere maintenance (GO:0032205)2.79247645
77establishment of protein localization to membrane (GO:0090150)2.76263901
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75316170
79positive regulation of meiosis (GO:0045836)2.74462374
80pteridine-containing compound biosynthetic process (GO:0042559)2.72259997
81regulation of appetite (GO:0032098)2.68159517
82protein targeting (GO:0006605)2.67428691
83rRNA modification (GO:0000154)2.64972391
84chromatin remodeling at centromere (GO:0031055)2.63048426
85detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.62780508
86piRNA metabolic process (GO:0034587)2.60455053
87platelet dense granule organization (GO:0060155)2.60032033
88mitochondrial RNA metabolic process (GO:0000959)2.59570073
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59514883
90hydrogen ion transmembrane transport (GO:1902600)2.58832435
91establishment of protein localization to organelle (GO:0072594)2.58748497
92positive regulation of meiotic cell cycle (GO:0051446)2.58206903
93CENP-A containing nucleosome assembly (GO:0034080)2.57411634
94termination of RNA polymerase III transcription (GO:0006386)2.55313008
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.55313008
96pseudouridine synthesis (GO:0001522)2.54320979
97regulation of response to food (GO:0032095)2.52527254
98telomere maintenance via telomerase (GO:0007004)2.52257181
99UTP biosynthetic process (GO:0006228)2.50879530
100protein neddylation (GO:0045116)2.50502355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.88031480
2EZH2_22144423_ChIP-Seq_EOC_Human4.62354062
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21779673
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40365814
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40047147
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13986825
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80103669
8VDR_22108803_ChIP-Seq_LS180_Human2.68329563
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49646501
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.45381559
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44272858
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41479971
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28278295
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96993930
15ELK1_19687146_ChIP-ChIP_HELA_Human1.91902459
16MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88368027
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86193259
18FOXP3_21729870_ChIP-Seq_TREG_Human1.84467420
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.79503038
20EWS_26573619_Chip-Seq_HEK293_Human1.77594342
21VDR_23849224_ChIP-Seq_CD4+_Human1.75805267
22ZNF274_21170338_ChIP-Seq_K562_Hela1.73614302
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70757866
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69910716
25FUS_26573619_Chip-Seq_HEK293_Human1.67839692
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65078671
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.64905486
28TTF2_22483619_ChIP-Seq_HELA_Human1.60914703
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60532706
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51578328
31IRF1_19129219_ChIP-ChIP_H3396_Human1.49449910
32MYC_18940864_ChIP-ChIP_HL60_Human1.49091291
33TP53_22573176_ChIP-Seq_HFKS_Human1.46086852
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.44348937
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43928268
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41506555
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40140387
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37725701
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34635614
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.34553581
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33143206
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29695965
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29589257
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29500676
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.29415112
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27669115
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26982198
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.26872887
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24068447
50NCOR_22424771_ChIP-Seq_293T_Human1.21864194
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21655631
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21262006
53BCAT_22108803_ChIP-Seq_LS180_Human1.21138716
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20798886
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20135576
56GBX2_23144817_ChIP-Seq_PC3_Human1.17439200
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17219396
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.16607129
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16553148
60ER_23166858_ChIP-Seq_MCF-7_Human1.14758010
61RNF2_27304074_Chip-Seq_NSC_Mouse1.14184200
62SOX2_19829295_ChIP-Seq_ESCs_Human1.12775517
63NANOG_19829295_ChIP-Seq_ESCs_Human1.12775517
64ERG_20517297_ChIP-Seq_VCAP_Human1.11847842
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.09513799
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07706024
67XRN2_22483619_ChIP-Seq_HELA_Human1.07138844
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06985565
69MYC_19829295_ChIP-Seq_ESCs_Human1.06581517
70IGF1R_20145208_ChIP-Seq_DFB_Human1.04107431
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02498469
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00557167
73P300_19829295_ChIP-Seq_ESCs_Human0.99764762
74REST_21632747_ChIP-Seq_MESCs_Mouse0.98844444
75ERA_21632823_ChIP-Seq_H3396_Human0.98422029
76AR_20517297_ChIP-Seq_VCAP_Human0.98051509
77GATA3_21878914_ChIP-Seq_MCF-7_Human0.95802161
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95025724
79MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94400786
80CBP_20019798_ChIP-Seq_JUKART_Human0.94299926
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94299926
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92227625
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91710452
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90360818
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.89608002
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89575602
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88560669
88NANOG_20526341_ChIP-Seq_ESCs_Human0.88472252
89GABP_19822575_ChIP-Seq_HepG2_Human0.87861162
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.87303077
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86442218
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86256505
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85811929
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.85668925
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84036534
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83738500
97HOXB7_26014856_ChIP-Seq_BT474_Human0.82471733
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.82321541
99E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82212220
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81808559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.91949263
2MP0009379_abnormal_foot_pigmentation4.12425015
3MP0003283_abnormal_digestive_organ3.55238094
4MP0006292_abnormal_olfactory_placode3.33540133
5MP0002938_white_spotting3.22854403
6MP0005646_abnormal_pituitary_gland3.01976514
7MP0008877_abnormal_DNA_methylation2.60115754
8MP0002163_abnormal_gland_morphology2.50190431
9MP0010030_abnormal_orbit_morphology2.47917704
10MP0002876_abnormal_thyroid_physiology2.37800613
11MP0000566_synostosis2.20934245
12MP0002138_abnormal_hepatobiliary_system2.03478517
13MP0004147_increased_porphyrin_level2.01032828
14MP0006276_abnormal_autonomic_nervous1.98764552
15MP0005075_abnormal_melanosome_morpholog1.97980203
16MP0002736_abnormal_nociception_after1.96257034
17MP0004885_abnormal_endolymph1.92435459
18MP0001968_abnormal_touch/_nociception1.87733997
19MP0008872_abnormal_physiological_respon1.85741506
20MP0008995_early_reproductive_senescence1.72002366
21MP0008789_abnormal_olfactory_epithelium1.68938318
22MP0004133_heterotaxia1.66459496
23MP0004142_abnormal_muscle_tone1.62528727
24MP0000372_irregular_coat_pigmentation1.60910269
25MP0000631_abnormal_neuroendocrine_gland1.60830191
26MP0002102_abnormal_ear_morphology1.60590668
27MP0002095_abnormal_skin_pigmentation1.59785512
28MP0001346_abnormal_lacrimal_gland1.57769914
29MP0005171_absent_coat_pigmentation1.57050238
30MP0005379_endocrine/exocrine_gland_phen1.53330494
31MP0002837_dystrophic_cardiac_calcinosis1.53090154
32MP0009697_abnormal_copulation1.50642962
33MP0006072_abnormal_retinal_apoptosis1.49645632
34MP0002234_abnormal_pharynx_morphology1.45097385
35MP0004145_abnormal_muscle_electrophysio1.43470584
36MP0003787_abnormal_imprinting1.42334442
37MP0003938_abnormal_ear_development1.41882199
38MP0005551_abnormal_eye_electrophysiolog1.37162734
39MP0003186_abnormal_redox_activity1.34606434
40MP0002735_abnormal_chemical_nociception1.33665496
41MP0010386_abnormal_urinary_bladder1.29863840
42MP0008875_abnormal_xenobiotic_pharmacok1.27775408
43MP0000049_abnormal_middle_ear1.26246353
44MP0001485_abnormal_pinna_reflex1.20919670
45MP0000026_abnormal_inner_ear1.20347724
46MP0004381_abnormal_hair_follicle1.20115227
47MP0005408_hypopigmentation1.17836373
48MP0002160_abnormal_reproductive_system1.17279977
49MP0003880_abnormal_central_pattern1.16502960
50MP0002277_abnormal_respiratory_mucosa1.06375444
51MP0009745_abnormal_behavioral_response1.06145224
52MP0003718_maternal_effect1.05490060
53MP0003011_delayed_dark_adaptation1.04243519
54MP0002282_abnormal_trachea_morphology1.04033520
55MP0001984_abnormal_olfaction1.02315355
56MP0005389_reproductive_system_phenotype1.01723087
57MP0000613_abnormal_salivary_gland0.96667364
58MP0008775_abnormal_heart_ventricle0.95785649
59MP0005394_taste/olfaction_phenotype0.94128805
60MP0005499_abnormal_olfactory_system0.94128805
61MP0005645_abnormal_hypothalamus_physiol0.92010435
62MP0003121_genomic_imprinting0.91711911
63MP0003937_abnormal_limbs/digits/tail_de0.90186150
64MP0002733_abnormal_thermal_nociception0.89641966
65MP0003119_abnormal_digestive_system0.89397529
66MP0003786_premature_aging0.86543129
67MP0002653_abnormal_ependyma_morphology0.86221169
68MP0001963_abnormal_hearing_physiology0.84880184
69MP0005084_abnormal_gallbladder_morpholo0.84127975
70MP0000230_abnormal_systemic_arterial0.80692466
71MP0009250_abnormal_appendicular_skeleto0.78776158
72MP0000534_abnormal_ureter_morphology0.78608145
73MP0002210_abnormal_sex_determination0.78505895
74MP0005670_abnormal_white_adipose0.77987355
75MP0000383_abnormal_hair_follicle0.77005712
76MP0001970_abnormal_pain_threshold0.76931891
77MP0003122_maternal_imprinting0.75847417
78MP0001919_abnormal_reproductive_system0.75680806
79MP0002272_abnormal_nervous_system0.73003885
80MP0002184_abnormal_innervation0.71931757
81MP0008058_abnormal_DNA_repair0.71907049
82MP0001986_abnormal_taste_sensitivity0.71826857
83MP0003646_muscle_fatigue0.70823850
84MP0002734_abnormal_mechanical_nocicepti0.70715679
85MP0009053_abnormal_anal_canal0.70553362
86MP0003936_abnormal_reproductive_system0.70469733
87MP0003183_abnormal_peptide_metabolism0.68862513
88MP0003806_abnormal_nucleotide_metabolis0.68478972
89MP0002233_abnormal_nose_morphology0.68438818
90MP0005253_abnormal_eye_physiology0.68381968
91MP0001293_anophthalmia0.67777795
92MP0003137_abnormal_impulse_conducting0.67767302
93MP0005636_abnormal_mineral_homeostasis0.67521467
94MP0005195_abnormal_posterior_eye0.67024861
95MP0000653_abnormal_sex_gland0.65189485
96MP0001440_abnormal_grooming_behavior0.64949323
97MP0001764_abnormal_homeostasis0.63928023
98MP0002638_abnormal_pupillary_reflex0.62845536
99MP0001119_abnormal_female_reproductive0.62576751
100MP0005377_hearing/vestibular/ear_phenot0.62093487

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.96393424
2Abnormality of cells of the erythroid lineage (HP:0012130)4.69079844
3Abnormality of the labia minora (HP:0012880)4.51235677
4Abnormality of alanine metabolism (HP:0010916)4.10097665
5Hyperalaninemia (HP:0003348)4.10097665
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.10097665
7Abnormal number of erythroid precursors (HP:0012131)4.08350054
8Acute necrotizing encephalopathy (HP:0006965)3.84371032
9Stenosis of the external auditory canal (HP:0000402)3.81244348
10Macrocytic anemia (HP:0001972)3.43707508
11Mitochondrial inheritance (HP:0001427)3.41714163
12Abnormal mitochondria in muscle tissue (HP:0008316)3.21368791
13Increased CSF lactate (HP:0002490)3.20514094
14Acute encephalopathy (HP:0006846)3.17416817
15Progressive macrocephaly (HP:0004481)3.09463793
16Septo-optic dysplasia (HP:0100842)3.03867496
17Pallor (HP:0000980)2.98238968
18Hepatocellular necrosis (HP:0001404)2.90571473
19Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87195881
20Pancreatic cysts (HP:0001737)2.82365865
21Esophageal atresia (HP:0002032)2.82081870
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75618075
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.75315957
24Constricted visual fields (HP:0001133)2.75015041
25Abnormality of midbrain morphology (HP:0002418)2.71963417
26Molar tooth sign on MRI (HP:0002419)2.71963417
27Cerebral edema (HP:0002181)2.68247841
28Abnormality of the renal collecting system (HP:0004742)2.66252305
29Renal Fanconi syndrome (HP:0001994)2.64547110
30Pancreatic fibrosis (HP:0100732)2.58010829
31Partial duplication of thumb phalanx (HP:0009944)2.55893232
32Absent septum pellucidum (HP:0001331)2.55311961
33Hepatic necrosis (HP:0002605)2.55274052
34Absent thumb (HP:0009777)2.54925088
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54882658
36Increased hepatocellular lipid droplets (HP:0006565)2.53722248
37Abnormality of the middle phalanges of the toes (HP:0010183)2.53375028
38Short hallux (HP:0010109)2.51677350
39Cystic liver disease (HP:0006706)2.51158794
40Asplenia (HP:0001746)2.45979035
41True hermaphroditism (HP:0010459)2.44091002
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.41855421
43Congenital, generalized hypertrichosis (HP:0004540)2.39890706
44Lipid accumulation in hepatocytes (HP:0006561)2.38630277
45Chromsome breakage (HP:0040012)2.36141029
46Partial duplication of the phalanx of hand (HP:0009999)2.34113817
47Abnormality of the aortic arch (HP:0012303)2.28849663
48Duplicated collecting system (HP:0000081)2.28553357
49Abnormality of cochlea (HP:0000375)2.27705358
50Aplasia/Hypoplasia of the hallux (HP:0008362)2.27181474
51Increased serum lactate (HP:0002151)2.24397897
52Gastrointestinal atresia (HP:0002589)2.23137801
53Triphalangeal thumb (HP:0001199)2.22981990
54Congenital sensorineural hearing impairment (HP:0008527)2.20214892
55Increased corneal curvature (HP:0100692)2.17303299
56Keratoconus (HP:0000563)2.17303299
57Optic disc pallor (HP:0000543)2.14921896
58Abnormal rod and cone electroretinograms (HP:0008323)2.14267118
59Abnormality of serum amino acid levels (HP:0003112)2.12405508
60Abolished electroretinogram (ERG) (HP:0000550)2.08810839
61Maternal diabetes (HP:0009800)2.06373192
62Increased serum pyruvate (HP:0003542)2.03783013
63Congenital stationary night blindness (HP:0007642)2.02618384
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00543976
65Lethargy (HP:0001254)1.96538778
66Nephronophthisis (HP:0000090)1.96506618
67Pendular nystagmus (HP:0012043)1.96328794
68Cutaneous finger syndactyly (HP:0010554)1.95010175
69Colon cancer (HP:0003003)1.94330932
70Duplication of thumb phalanx (HP:0009942)1.91188001
71Methylmalonic acidemia (HP:0002912)1.90885216
72Lactic acidosis (HP:0003128)1.90792698
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90038582
74Fused cervical vertebrae (HP:0002949)1.89091973
75Decreased central vision (HP:0007663)1.88362191
76Horseshoe kidney (HP:0000085)1.84759141
77Medial flaring of the eyebrow (HP:0010747)1.84336536
78Abnormality of the septum pellucidum (HP:0007375)1.84054482
79Hypoplasia of the radius (HP:0002984)1.83710711
80Mesomelia (HP:0003027)1.83100664
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.82967832
82Adrenal hypoplasia (HP:0000835)1.81426357
83Cutaneous syndactyly (HP:0012725)1.80789297
84Anencephaly (HP:0002323)1.80566618
85Birth length less than 3rd percentile (HP:0003561)1.80431418
86Hyperglycinemia (HP:0002154)1.79811192
87Neutropenia (HP:0001875)1.79027331
88Respiratory failure (HP:0002878)1.78847359
89Abnormality of the phalanges of the 5th finger (HP:0004213)1.78595520
90Symphalangism affecting the phalanges of the hand (HP:0009773)1.77617639
91Exercise intolerance (HP:0003546)1.77372068
92Chronic otitis media (HP:0000389)1.74692952
93Abnormality of the ileum (HP:0001549)1.73734865
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.72549991
95Generalized aminoaciduria (HP:0002909)1.71692164
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.69533939
97Hypoplasia of the ulna (HP:0003022)1.69310613
98Large for gestational age (HP:0001520)1.65436842
99Genital tract atresia (HP:0001827)1.65158084
100Humeroradial synostosis (HP:0003041)1.64984467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK24.26516257
2BCKDK2.83558559
3MAP2K62.82622541
4TLK12.61221613
5MAP4K22.59687948
6VRK22.59176928
7MAP3K122.13348541
8GRK12.10865360
9EPHB21.89256094
10PASK1.86095490
11WNK41.85005205
12NME11.78122633
13NME21.65974503
14FGFR21.63404040
15ADRBK21.63050137
16PDK21.57684852
17FRK1.56830939
18TNIK1.55565346
19STK391.55282341
20DYRK21.52465753
21WNK31.52311161
22FES1.50625116
23BUB11.49809518
24NUAK11.46400973
25KDR1.44292585
26ACVR1B1.40055205
27MAP3K111.35096988
28MST41.31818679
29TAF11.27925773
30PLK41.24651757
31VRK11.22065674
32CDK81.21904600
33BMPR1B1.20407475
34CAMK11.19307790
35DAPK21.18514806
36TGFBR11.17469958
37CDK191.13586797
38NEK11.11491751
39INSRR1.07250178
40LRRK21.01797736
41PINK11.01624521
42OXSR11.00652809
43SGK4940.96011922
44SGK2230.96011922
45CDC70.95317567
46STK160.95204886
47AURKA0.92059645
48IRAK40.91261846
49ZAK0.88028979
50PRKCQ0.87351397
51MAP3K50.82613354
52TEC0.82522613
53MAP2K70.81577882
54TAOK30.80943050
55TXK0.80150691
56ADRBK10.79325024
57LMTK20.78677179
58OBSCN0.78561900
59DAPK30.77073365
60CCNB10.76396798
61PRKCE0.73966117
62PHKG10.73309607
63PHKG20.73309607
64STK40.66001790
65AURKB0.65440370
66PLK20.65087173
67ATR0.64293748
68STK240.62949636
69CSNK2A20.59713858
70ITK0.59022666
71MUSK0.58678004
72CSNK1A10.57715882
73PAK30.57147260
74CASK0.55025934
75KIT0.53568363
76PRKACA0.53469675
77WNK10.52245712
78PIM20.52175751
79CSNK2A10.49593986
80EIF2AK10.46837860
81CHEK20.45624081
82STK38L0.44433300
83PRKCG0.44318029
84MYLK0.44170031
85PAK60.43473488
86SGK20.42099690
87PNCK0.41454294
88PIK3CA0.41325100
89PRKCH0.39309696
90PRKCA0.38914700
91PLK10.38769541
92RPS6KB20.37881152
93ABL20.37417899
94PLK30.36731510
95EPHA40.35119404
96CDK90.34708503
97PRKCI0.34327112
98RPS6KA50.33848474
99PKN10.32867140
100NTRK20.32588004

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.27126408
2Oxidative phosphorylation_Homo sapiens_hsa001904.24028747
3Parkinsons disease_Homo sapiens_hsa050123.44852664
4Protein export_Homo sapiens_hsa030603.08745410
5Proteasome_Homo sapiens_hsa030502.99396947
6Homologous recombination_Homo sapiens_hsa034402.70768323
7Huntingtons disease_Homo sapiens_hsa050162.47575694
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.33979339
9Mismatch repair_Homo sapiens_hsa034302.29031675
10Alzheimers disease_Homo sapiens_hsa050102.28042949
11Cardiac muscle contraction_Homo sapiens_hsa042602.11190222
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05893338
13RNA polymerase_Homo sapiens_hsa030202.02656545
14One carbon pool by folate_Homo sapiens_hsa006701.94337741
15Primary immunodeficiency_Homo sapiens_hsa053401.81690014
16Basal transcription factors_Homo sapiens_hsa030221.67766280
17RNA degradation_Homo sapiens_hsa030181.65824587
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.61600847
19DNA replication_Homo sapiens_hsa030301.55042949
20Caffeine metabolism_Homo sapiens_hsa002321.44619921
21Fanconi anemia pathway_Homo sapiens_hsa034601.43982140
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42736806
23Nucleotide excision repair_Homo sapiens_hsa034201.41315205
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37830639
25Linoleic acid metabolism_Homo sapiens_hsa005911.37332209
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27438272
27Phototransduction_Homo sapiens_hsa047441.27303864
28Purine metabolism_Homo sapiens_hsa002301.27115721
29Pyrimidine metabolism_Homo sapiens_hsa002401.17149079
30Collecting duct acid secretion_Homo sapiens_hsa049661.10857676
31Non-homologous end-joining_Homo sapiens_hsa034501.07066762
32Propanoate metabolism_Homo sapiens_hsa006401.07042234
33Folate biosynthesis_Homo sapiens_hsa007901.05779098
34Butanoate metabolism_Homo sapiens_hsa006501.05400887
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05161518
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03062438
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01337200
38Olfactory transduction_Homo sapiens_hsa047400.97939152
39Ether lipid metabolism_Homo sapiens_hsa005650.97125426
40Regulation of autophagy_Homo sapiens_hsa041400.96443927
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92905504
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91408120
43Asthma_Homo sapiens_hsa053100.91396290
44RNA transport_Homo sapiens_hsa030130.91299258
45Peroxisome_Homo sapiens_hsa041460.91025797
46Base excision repair_Homo sapiens_hsa034100.89999397
47Taste transduction_Homo sapiens_hsa047420.87575364
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.86073901
49Sulfur relay system_Homo sapiens_hsa041220.83369706
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.79680104
51Tryptophan metabolism_Homo sapiens_hsa003800.77060090
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.74879829
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74139214
54Nitrogen metabolism_Homo sapiens_hsa009100.73976480
55Fatty acid biosynthesis_Homo sapiens_hsa000610.72484642
56Mineral absorption_Homo sapiens_hsa049780.69215042
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68137426
58Metabolic pathways_Homo sapiens_hsa011000.67351506
59Chemical carcinogenesis_Homo sapiens_hsa052040.65550561
60Allograft rejection_Homo sapiens_hsa053300.63008337
61Nicotine addiction_Homo sapiens_hsa050330.62965612
62Hematopoietic cell lineage_Homo sapiens_hsa046400.61248997
63Autoimmune thyroid disease_Homo sapiens_hsa053200.60885600
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60800581
65Spliceosome_Homo sapiens_hsa030400.59990121
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59891411
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58166550
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57671209
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55577281
70Arachidonic acid metabolism_Homo sapiens_hsa005900.55554909
71Steroid biosynthesis_Homo sapiens_hsa001000.55435910
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55414453
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54088288
74Basal cell carcinoma_Homo sapiens_hsa052170.53057294
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52411736
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51249932
77Morphine addiction_Homo sapiens_hsa050320.48137798
78Hedgehog signaling pathway_Homo sapiens_hsa043400.43649740
79mRNA surveillance pathway_Homo sapiens_hsa030150.43065210
80Glycerolipid metabolism_Homo sapiens_hsa005610.41105075
81Sulfur metabolism_Homo sapiens_hsa009200.40746106
82Retinol metabolism_Homo sapiens_hsa008300.40251235
83Salivary secretion_Homo sapiens_hsa049700.39397813
84Fat digestion and absorption_Homo sapiens_hsa049750.37168471
85GABAergic synapse_Homo sapiens_hsa047270.32937829
86Rheumatoid arthritis_Homo sapiens_hsa053230.32237524
87Glutathione metabolism_Homo sapiens_hsa004800.30756793
88beta-Alanine metabolism_Homo sapiens_hsa004100.30543459
89Type I diabetes mellitus_Homo sapiens_hsa049400.30329398
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29623448
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29272693
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28579969
93Graft-versus-host disease_Homo sapiens_hsa053320.28048162
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26520733
95Tyrosine metabolism_Homo sapiens_hsa003500.25849387
96Glutamatergic synapse_Homo sapiens_hsa047240.25371531
97Dorso-ventral axis formation_Homo sapiens_hsa043200.24638138
98Cocaine addiction_Homo sapiens_hsa050300.21622498
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21616199
100Serotonergic synapse_Homo sapiens_hsa047260.19332022

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