RPL10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.81811978
2ribosomal small subunit assembly (GO:0000028)6.13295983
3cytidine deamination (GO:0009972)6.10602149
4cytidine metabolic process (GO:0046087)6.10602149
5cytidine catabolic process (GO:0006216)6.10602149
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.00516425
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30481350
8ATP synthesis coupled proton transport (GO:0015986)5.30481350
9viral transcription (GO:0019083)5.26906673
10pyrimidine ribonucleoside catabolic process (GO:0046133)5.20532768
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15481210
12translational termination (GO:0006415)5.03512230
13translational elongation (GO:0006414)4.71906770
14protein neddylation (GO:0045116)4.61878096
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57093272
16protein targeting to ER (GO:0045047)4.48747403
17cotranslational protein targeting to membrane (GO:0006613)4.48454668
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.33073069
19maturation of SSU-rRNA (GO:0030490)4.29527044
20protein localization to endoplasmic reticulum (GO:0070972)4.27845949
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.26314634
22respiratory electron transport chain (GO:0022904)4.07351969
23electron transport chain (GO:0022900)4.04415340
24ribosomal small subunit biogenesis (GO:0042274)3.92577228
25viral life cycle (GO:0019058)3.79924207
26regulation of regulatory T cell differentiation (GO:0045589)3.77771222
27cellular protein complex disassembly (GO:0043624)3.76702249
28sequestering of actin monomers (GO:0042989)3.74182956
29protein complex biogenesis (GO:0070271)3.64200463
30positive thymic T cell selection (GO:0045059)3.58928634
31ribosomal large subunit biogenesis (GO:0042273)3.53906461
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49793383
33translational initiation (GO:0006413)3.46524886
34positive T cell selection (GO:0043368)3.45681586
35translation (GO:0006412)3.37927139
36behavioral response to nicotine (GO:0035095)3.36323974
37termination of RNA polymerase III transcription (GO:0006386)3.31659991
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.31659991
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30691526
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.29940078
41water-soluble vitamin biosynthetic process (GO:0042364)3.28235085
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.28171789
43NADH dehydrogenase complex assembly (GO:0010257)3.28171789
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28171789
45mitochondrial respiratory chain complex assembly (GO:0033108)3.28025466
46proteasome assembly (GO:0043248)3.22777963
47regulation of isotype switching to IgG isotypes (GO:0048302)3.21881157
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18358511
49actin nucleation (GO:0045010)3.17224074
50negative T cell selection (GO:0043383)3.12180145
51ATP biosynthetic process (GO:0006754)3.11845814
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09550547
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07855973
54regulation of cellular amino acid metabolic process (GO:0006521)3.03777233
55GTP biosynthetic process (GO:0006183)3.02282202
56regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.02073008
57protein complex disassembly (GO:0043241)3.01014173
58hydrogen ion transmembrane transport (GO:1902600)3.00984485
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00593260
60positive regulation of tolerance induction (GO:0002645)2.99649909
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98528548
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.98033932
63negative regulation of T cell apoptotic process (GO:0070233)2.97960135
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96635514
65pyrimidine nucleoside catabolic process (GO:0046135)2.96327607
66metallo-sulfur cluster assembly (GO:0031163)2.94232973
67iron-sulfur cluster assembly (GO:0016226)2.94232973
68protein targeting to membrane (GO:0006612)2.90787865
69cytolysis (GO:0019835)2.90496897
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89728160
71chaperone-mediated protein transport (GO:0072321)2.89128963
72macromolecular complex disassembly (GO:0032984)2.85605529
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85412985
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85412985
75response to pheromone (GO:0019236)2.85138230
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84528288
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84528288
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84528288
79proton transport (GO:0015992)2.84341603
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83218345
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83218345
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.81761099
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81376637
84positive regulation of prostaglandin secretion (GO:0032308)2.80150295
85platelet dense granule organization (GO:0060155)2.79715083
86hydrogen transport (GO:0006818)2.77803815
87positive regulation of defense response to virus by host (GO:0002230)2.77249027
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76752071
89response to interferon-beta (GO:0035456)2.75937283
90base-excision repair, AP site formation (GO:0006285)2.75567830
91regulation of chronic inflammatory response (GO:0002676)2.75252236
92regulation of T cell tolerance induction (GO:0002664)2.74349404
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.74310581
94cellular component biogenesis (GO:0044085)2.73719656
95positive regulation of calcium-mediated signaling (GO:0050850)2.71575441
96positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.71172901
97regulation of B cell receptor signaling pathway (GO:0050855)2.70789019
98signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67663324
99signal transduction involved in DNA damage checkpoint (GO:0072422)2.67663324
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67283399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14576119
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.71399256
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.50588704
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.47135759
5VDR_22108803_ChIP-Seq_LS180_Human3.07941703
6EZH2_22144423_ChIP-Seq_EOC_Human3.04887618
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94724069
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86542581
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85123187
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83670897
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.73088280
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67390899
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54385063
14VDR_23849224_ChIP-Seq_CD4+_Human2.39642135
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.34547942
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27355225
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22425430
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20852976
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05437081
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04845611
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86774143
22ZNF274_21170338_ChIP-Seq_K562_Hela1.86695364
23FOXP3_21729870_ChIP-Seq_TREG_Human1.81600732
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77881771
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.70127377
26IGF1R_20145208_ChIP-Seq_DFB_Human1.65458074
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.59324714
28MYC_18940864_ChIP-ChIP_HL60_Human1.57299906
29ELK1_19687146_ChIP-ChIP_HELA_Human1.52198952
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50162221
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.49316648
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47651761
33MYB_26560356_Chip-Seq_TH2_Human1.45872130
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.45015155
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44821458
36PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.43498383
37TP53_22573176_ChIP-Seq_HFKS_Human1.42891056
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42296673
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40749465
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40420266
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36738459
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34741122
43AR_20517297_ChIP-Seq_VCAP_Human1.32850666
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32474814
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31732771
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31103764
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29970951
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26800245
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26015138
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.23923363
51NANOG_20526341_ChIP-Seq_ESCs_Human1.23727597
52TAF2_19829295_ChIP-Seq_ESCs_Human1.22447706
53NCOR_22424771_ChIP-Seq_293T_Human1.21020078
54GATA3_26560356_Chip-Seq_TH2_Human1.20066573
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.18868552
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.17670574
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17670574
58IRF1_19129219_ChIP-ChIP_H3396_Human1.17217124
59EWS_26573619_Chip-Seq_HEK293_Human1.16214700
60BCL6_27268052_Chip-Seq_Bcells_Human1.14806028
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14291661
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13620924
63MYC_19829295_ChIP-Seq_ESCs_Human1.11897238
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.10326298
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10184660
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09459686
67ER_23166858_ChIP-Seq_MCF-7_Human1.09411547
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08468555
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07873516
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06780030
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05943988
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05824571
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05701187
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05251151
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04607220
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.03624523
77CTCF_20526341_ChIP-Seq_ESCs_Human1.03472352
78GATA3_27048872_Chip-Seq_THYMUS_Human1.03135106
79ERA_21632823_ChIP-Seq_H3396_Human1.02731283
80RUNX_20019798_ChIP-Seq_JUKART_Human1.01639809
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01422972
82HTT_18923047_ChIP-ChIP_STHdh_Human1.01276639
83ERG_20517297_ChIP-Seq_VCAP_Human1.00854006
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00303059
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.00072174
86TTF2_22483619_ChIP-Seq_HELA_Human0.98691288
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95007934
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94845236
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94713003
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94481084
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93376866
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92971418
93FUS_26573619_Chip-Seq_HEK293_Human0.92853106
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.92851052
95NANOG_19829295_ChIP-Seq_ESCs_Human0.91851267
96SOX2_19829295_ChIP-Seq_ESCs_Human0.91851267
97P53_21459846_ChIP-Seq_SAOS-2_Human0.91798580
98P300_27268052_Chip-Seq_Bcells_Human0.90147070
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89920625
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89903499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.78333270
2MP0009379_abnormal_foot_pigmentation3.15067833
3MP0001835_abnormal_antigen_presentation3.08161686
4MP0004145_abnormal_muscle_electrophysio2.52019670
5MP0002102_abnormal_ear_morphology2.46381432
6MP0003763_abnormal_thymus_physiology2.37284712
7MP0009785_altered_susceptibility_to2.36433489
8MP0001873_stomach_inflammation2.29303052
9MP0009333_abnormal_splenocyte_physiolog2.21783011
10MP0004147_increased_porphyrin_level2.11698582
11MP0003646_muscle_fatigue2.09583738
12MP0006072_abnormal_retinal_apoptosis2.08320143
13MP0006292_abnormal_olfactory_placode2.01428849
14MP0008872_abnormal_physiological_respon1.92081131
15MP0003806_abnormal_nucleotide_metabolis1.83521416
16MP0003866_abnormal_defecation1.80686383
17MP0000372_irregular_coat_pigmentation1.80332706
18MP0001800_abnormal_humoral_immune1.78682177
19MP0005646_abnormal_pituitary_gland1.77867977
20MP0002148_abnormal_hypersensitivity_rea1.77697999
21MP0005000_abnormal_immune_tolerance1.76496886
22MP0005645_abnormal_hypothalamus_physiol1.73643911
23MP0005551_abnormal_eye_electrophysiolog1.68505658
24MP0001968_abnormal_touch/_nociception1.67765503
25MP0002166_altered_tumor_susceptibility1.62869163
26MP0002837_dystrophic_cardiac_calcinosis1.61743022
27MP0002723_abnormal_immune_serum1.60548302
28MP0002638_abnormal_pupillary_reflex1.60097306
29MP0002420_abnormal_adaptive_immunity1.58082953
30MP0002163_abnormal_gland_morphology1.57067255
31MP0001905_abnormal_dopamine_level1.56357599
32MP0001819_abnormal_immune_cell1.53351066
33MP0005377_hearing/vestibular/ear_phenot1.49535349
34MP0003878_abnormal_ear_physiology1.49535349
35MP0004142_abnormal_muscle_tone1.49391241
36MP0001790_abnormal_immune_system1.49235557
37MP0005387_immune_system_phenotype1.49235557
38MP0008875_abnormal_xenobiotic_pharmacok1.49113240
39MP0002736_abnormal_nociception_after1.48869510
40MP0005025_abnormal_response_to1.47836181
41MP0000685_abnormal_immune_system1.45913498
42MP0004885_abnormal_endolymph1.44835796
43MP0002277_abnormal_respiratory_mucosa1.43243771
44MP0001919_abnormal_reproductive_system1.40891265
45MP0003786_premature_aging1.40034267
46MP0005389_reproductive_system_phenotype1.33187126
47MP0005075_abnormal_melanosome_morpholog1.33052384
48MP0002095_abnormal_skin_pigmentation1.28392830
49MP0005253_abnormal_eye_physiology1.26960271
50MP0003011_delayed_dark_adaptation1.26545077
51MP0008877_abnormal_DNA_methylation1.25255753
52MP0002452_abnormal_antigen_presenting1.24896727
53MP0002006_tumorigenesis1.24851512
54MP0003195_calcinosis1.24300487
55MP0002933_joint_inflammation1.19892808
56MP0005084_abnormal_gallbladder_morpholo1.19341031
57MP0000716_abnormal_immune_system1.16524484
58MP0006082_CNS_inflammation1.14614603
59MP0002405_respiratory_system_inflammati1.11548436
60MP0003787_abnormal_imprinting1.10403340
61MP0001986_abnormal_taste_sensitivity1.09676745
62MP0002138_abnormal_hepatobiliary_system1.09479727
63MP0002398_abnormal_bone_marrow1.08209511
64MP0001485_abnormal_pinna_reflex1.07070635
65MP0002876_abnormal_thyroid_physiology1.06480256
66MP0002160_abnormal_reproductive_system1.05695272
67MP0006276_abnormal_autonomic_nervous1.05140814
68MP0001845_abnormal_inflammatory_respons1.01428324
69MP0004742_abnormal_vestibular_system0.99642138
70MP0005083_abnormal_biliary_tract0.99277759
71MP0010155_abnormal_intestine_physiology0.97554881
72MP0000689_abnormal_spleen_morphology0.96669038
73MP0000703_abnormal_thymus_morphology0.95455745
74MP0005410_abnormal_fertilization0.94898220
75MP0006036_abnormal_mitochondrial_physio0.93242441
76MP0002722_abnormal_immune_system0.93124701
77MP0009764_decreased_sensitivity_to0.92975012
78MP0002234_abnormal_pharynx_morphology0.92915350
79MP0002429_abnormal_blood_cell0.87617310
80MP0001529_abnormal_vocalization0.87293127
81MP0009745_abnormal_behavioral_response0.86759133
82MP0003283_abnormal_digestive_organ0.85920174
83MP0008995_early_reproductive_senescence0.85243890
84MP0005379_endocrine/exocrine_gland_phen0.83654120
85MP0005636_abnormal_mineral_homeostasis0.83232802
86MP0002272_abnormal_nervous_system0.79700970
87MP0008789_abnormal_olfactory_epithelium0.79301997
88MP0001764_abnormal_homeostasis0.78912696
89MP0003880_abnormal_central_pattern0.77991788
90MP0008469_abnormal_protein_level0.76034780
91MP0002693_abnormal_pancreas_physiology0.75968885
92MP0001970_abnormal_pain_threshold0.74600020
93MP0001663_abnormal_digestive_system0.73335147
94MP0010386_abnormal_urinary_bladder0.71346210
95MP0002653_abnormal_ependyma_morphology0.70724256
96MP0003137_abnormal_impulse_conducting0.70168832
97MP0005360_urolithiasis0.69765428
98MP0001440_abnormal_grooming_behavior0.69617231
99MP0000049_abnormal_middle_ear0.69069402
100MP0001963_abnormal_hearing_physiology0.68940799

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.85013000
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.66668109
3Mitochondrial inheritance (HP:0001427)4.59833167
4Abnormal mitochondria in muscle tissue (HP:0008316)4.36552663
5Elevated erythrocyte sedimentation rate (HP:0003565)4.30370735
6Aplastic anemia (HP:0001915)4.10870370
7Congenital stationary night blindness (HP:0007642)4.08914921
8Acute encephalopathy (HP:0006846)3.98771146
9Progressive macrocephaly (HP:0004481)3.97992802
10Increased CSF lactate (HP:0002490)3.87975791
113-Methylglutaconic aciduria (HP:0003535)3.82728993
12Increased hepatocellular lipid droplets (HP:0006565)3.81702595
13Abnormal rod and cone electroretinograms (HP:0008323)3.64231165
14Hepatocellular necrosis (HP:0001404)3.53148268
15IgG deficiency (HP:0004315)3.52728625
16Renal Fanconi syndrome (HP:0001994)3.42967473
17Lipid accumulation in hepatocytes (HP:0006561)3.40982171
18Increased intramyocellular lipid droplets (HP:0012240)3.15515700
19Cerebral edema (HP:0002181)3.14703905
20Hepatic necrosis (HP:0002605)3.07061240
21Pancreatic cysts (HP:0001737)2.98004495
22Decreased central vision (HP:0007663)2.94778282
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92943710
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92943710
25Optic disc pallor (HP:0000543)2.92844305
26Increased IgM level (HP:0003496)2.89656656
27Abnormality of cells of the erythroid lineage (HP:0012130)2.89276801
28Attenuation of retinal blood vessels (HP:0007843)2.78650362
29Abnormality of T cell number (HP:0011839)2.76163004
30Exertional dyspnea (HP:0002875)2.75278571
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.75031709
32T lymphocytopenia (HP:0005403)2.74297986
33Abnormality of midbrain morphology (HP:0002418)2.70423682
34Molar tooth sign on MRI (HP:0002419)2.70423682
35Reticulocytopenia (HP:0001896)2.69142228
36Abnormal number of erythroid precursors (HP:0012131)2.69077766
37Hypoproteinemia (HP:0003075)2.68055752
38Autoimmune hemolytic anemia (HP:0001890)2.65537193
39Severe combined immunodeficiency (HP:0004430)2.63170905
40Increased muscle lipid content (HP:0009058)2.61054218
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60292191
42Increased serum lactate (HP:0002151)2.57913105
43Abnormality of the prostate (HP:0008775)2.54945343
44Stomatitis (HP:0010280)2.53741214
45Lactic acidosis (HP:0003128)2.52512746
46Macrocytic anemia (HP:0001972)2.50280985
47Abolished electroretinogram (ERG) (HP:0000550)2.47516019
48Congenital, generalized hypertrichosis (HP:0004540)2.46263569
49Pancreatic fibrosis (HP:0100732)2.44119046
50Constricted visual fields (HP:0001133)2.44055790
51Pendular nystagmus (HP:0012043)2.42323838
52Abnormality of B cell number (HP:0010975)2.34620621
53True hermaphroditism (HP:0010459)2.33137734
54Respiratory failure (HP:0002878)2.32795739
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31848094
56Abnormality of T cells (HP:0002843)2.30685112
57Stenosis of the external auditory canal (HP:0000402)2.22868192
58Exercise intolerance (HP:0003546)2.21734032
59Increased corneal curvature (HP:0100692)2.20600775
60Keratoconus (HP:0000563)2.20600775
61Pancytopenia (HP:0001876)2.13103972
62Abnormality of renal resorption (HP:0011038)2.10910204
63Pallor (HP:0000980)2.10750292
64Lethargy (HP:0001254)2.07720352
65Type 2 muscle fiber atrophy (HP:0003554)2.06364989
66Thyroiditis (HP:0100646)2.05471300
67Leukodystrophy (HP:0002415)1.99250869
68Type II lissencephaly (HP:0007260)1.97642614
69Methylmalonic acidemia (HP:0002912)1.97491386
70Asplenia (HP:0001746)1.96988110
71Respiratory difficulties (HP:0002880)1.92228559
72Glycosuria (HP:0003076)1.90491123
73Abnormality of urine glucose concentration (HP:0011016)1.90491123
74Autoimmune thrombocytopenia (HP:0001973)1.90454777
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.89708602
76Hyperphosphaturia (HP:0003109)1.89013624
77B lymphocytopenia (HP:0010976)1.88029347
78Abnormality of eosinophils (HP:0001879)1.87618784
79Absent thumb (HP:0009777)1.87496915
80Renal cortical cysts (HP:0000803)1.87231320
81Abnormality of the renal cortex (HP:0011035)1.83946556
82Colon cancer (HP:0003003)1.83361838
83Nephronophthisis (HP:0000090)1.81730562
84Combined immunodeficiency (HP:0005387)1.81310410
85Sclerocornea (HP:0000647)1.81253151
86Encephalitis (HP:0002383)1.79579005
87Muscle fiber atrophy (HP:0100295)1.77967690
88Prostate neoplasm (HP:0100787)1.77387460
89Methylmalonic aciduria (HP:0012120)1.77354110
90Type I transferrin isoform profile (HP:0003642)1.72528908
91Chronic diarrhea (HP:0002028)1.71511556
92Polydipsia (HP:0001959)1.70714290
93Abnormal drinking behavior (HP:0030082)1.70714290
94Generalized aminoaciduria (HP:0002909)1.68776081
95X-linked dominant inheritance (HP:0001423)1.65487442
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65457610
97Abnormality of alanine metabolism (HP:0010916)1.65457610
98Hyperalaninemia (HP:0003348)1.65457610
99Abnormal albumin level (HP:0012116)1.61934165
100Hypoalbuminemia (HP:0003073)1.61934165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.12508600
2TESK24.26340120
3KDR4.15546230
4VRK23.07755315
5BCKDK2.88884579
6TLK12.67347290
7ADRBK22.42198799
8MAP4K12.34055770
9GRK12.33473218
10ZAK2.27994881
11MAP4K22.10025440
12TAOK31.99252453
13NUAK11.98759790
14LIMK11.96407065
15TIE11.95768237
16VRK11.92782290
17MUSK1.91444656
18ITK1.88743799
19PASK1.76450042
20CDK191.75200719
21TEC1.65554635
22NME21.53133183
23TESK11.40855118
24WNK41.39285723
25STK161.34664462
26SYK1.22582292
27FRK1.14201462
28FES1.11426937
29WNK31.04262844
30PRKCQ1.03517764
31CAMKK21.03057444
32MST41.02414832
33BTK1.00944225
34OBSCN0.99875152
35IKBKB0.99248371
36MAP3K110.98021868
37INSRR0.97329421
38GRK60.96834725
39PINK10.96353341
40KIT0.94494911
41LCK0.93618914
42OXSR10.86306160
43NME10.85044773
44DYRK20.83284780
45RPS6KA50.82906656
46MAP2K60.81678066
47MAPKAPK30.79165983
48CSK0.78833977
49MAP3K120.78224316
50CAMKK10.72005654
51PHKG20.71619372
52PHKG10.71619372
53LYN0.71487295
54CSNK1G30.70357820
55ADRBK10.70145730
56GRK70.70054620
57TNK20.69942493
58PIK3CA0.69810408
59DAPK10.67425833
60AURKA0.66278330
61MAPK130.64021670
62SCYL20.62019045
63IKBKE0.58705961
64CSNK1G20.58081185
65ZAP700.57126392
66CSF1R0.56564631
67STK390.55338709
68DAPK30.54681619
69MAPKAPK50.54576069
70BUB10.52653558
71JAK30.52643203
72PIK3CG0.51985645
73MAP2K70.50251570
74GRK50.49998800
75PRKACA0.49351688
76MYLK0.49037512
77BMPR20.47588836
78DAPK20.46784957
79PRKCA0.46220677
80CSNK1G10.44607918
81CSNK2A10.43086658
82TBK10.42881838
83CSNK2A20.42265508
84IGF1R0.41760821
85ILK0.41574926
86CSNK1A1L0.40876331
87TAF10.40856617
88BMPR1B0.39874918
89FLT30.39076524
90PIM10.38093122
91CAMK10.35280923
92PRKCH0.31419417
93LRRK20.31349449
94FYN0.31107246
95CAMK2A0.29826047
96ATR0.28955026
97RPS6KA40.28477301
98PRKCD0.27654979
99HCK0.27548749
100AURKB0.27222626

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.73581201
2Oxidative phosphorylation_Homo sapiens_hsa001904.07172715
3Proteasome_Homo sapiens_hsa030504.02635659
4Primary immunodeficiency_Homo sapiens_hsa053403.44146118
5Parkinsons disease_Homo sapiens_hsa050123.38182051
6RNA polymerase_Homo sapiens_hsa030202.64956580
7Autoimmune thyroid disease_Homo sapiens_hsa053202.50355328
8Graft-versus-host disease_Homo sapiens_hsa053322.48861162
9Allograft rejection_Homo sapiens_hsa053302.48246450
10Alzheimers disease_Homo sapiens_hsa050102.29293603
11Asthma_Homo sapiens_hsa053102.20313469
12Huntingtons disease_Homo sapiens_hsa050162.18683308
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05680629
14Cardiac muscle contraction_Homo sapiens_hsa042602.02348975
15Protein export_Homo sapiens_hsa030602.01966235
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01953002
17Antigen processing and presentation_Homo sapiens_hsa046121.92777726
18Type I diabetes mellitus_Homo sapiens_hsa049401.85463169
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.79596255
20Phototransduction_Homo sapiens_hsa047441.69966871
21Hematopoietic cell lineage_Homo sapiens_hsa046401.58207008
22Linoleic acid metabolism_Homo sapiens_hsa005911.49241852
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42058207
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38325917
25Pyrimidine metabolism_Homo sapiens_hsa002401.32505526
26Rheumatoid arthritis_Homo sapiens_hsa053231.29170969
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23872505
28Homologous recombination_Homo sapiens_hsa034401.22390417
29T cell receptor signaling pathway_Homo sapiens_hsa046601.16942562
30Nitrogen metabolism_Homo sapiens_hsa009101.16335561
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14268186
32RNA degradation_Homo sapiens_hsa030181.10102107
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04409560
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01127563
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00837296
36One carbon pool by folate_Homo sapiens_hsa006700.99592103
37Purine metabolism_Homo sapiens_hsa002300.96500469
38Peroxisome_Homo sapiens_hsa041460.96164351
39Nucleotide excision repair_Homo sapiens_hsa034200.93377810
40Basal transcription factors_Homo sapiens_hsa030220.92585093
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87710813
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85918890
43Systemic lupus erythematosus_Homo sapiens_hsa053220.82976875
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80595581
45Base excision repair_Homo sapiens_hsa034100.80491220
46Olfactory transduction_Homo sapiens_hsa047400.77645348
47Viral myocarditis_Homo sapiens_hsa054160.75971698
48DNA replication_Homo sapiens_hsa030300.74408946
49Fanconi anemia pathway_Homo sapiens_hsa034600.74072043
50Spliceosome_Homo sapiens_hsa030400.73425485
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71493492
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70892039
53Caffeine metabolism_Homo sapiens_hsa002320.70839576
54Chemical carcinogenesis_Homo sapiens_hsa052040.69597985
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.69376829
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.68731682
57Propanoate metabolism_Homo sapiens_hsa006400.67884367
58Arachidonic acid metabolism_Homo sapiens_hsa005900.67699798
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66317745
60Sulfur metabolism_Homo sapiens_hsa009200.64746039
61Retinol metabolism_Homo sapiens_hsa008300.62320035
62Ether lipid metabolism_Homo sapiens_hsa005650.60461482
63Regulation of autophagy_Homo sapiens_hsa041400.59625188
64Butanoate metabolism_Homo sapiens_hsa006500.59596354
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.58479282
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58254485
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.56789090
68Metabolic pathways_Homo sapiens_hsa011000.56737728
69Collecting duct acid secretion_Homo sapiens_hsa049660.55626242
70Tryptophan metabolism_Homo sapiens_hsa003800.53795819
71Fat digestion and absorption_Homo sapiens_hsa049750.53232861
72Mismatch repair_Homo sapiens_hsa034300.52360200
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.51806827
74Measles_Homo sapiens_hsa051620.50541568
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49897816
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49128174
77Nicotine addiction_Homo sapiens_hsa050330.48317798
78Malaria_Homo sapiens_hsa051440.44723800
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43854995
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.43742638
81Morphine addiction_Homo sapiens_hsa050320.42318407
82Sulfur relay system_Homo sapiens_hsa041220.41666092
83Folate biosynthesis_Homo sapiens_hsa007900.40777776
84Taste transduction_Homo sapiens_hsa047420.39944614
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39089661
86RNA transport_Homo sapiens_hsa030130.38662327
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32954569
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30373257
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29007150
90Salivary secretion_Homo sapiens_hsa049700.28005821
91Staphylococcus aureus infection_Homo sapiens_hsa051500.27382667
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25319606
93Epstein-Barr virus infection_Homo sapiens_hsa051690.25203733
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24541544
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24447608
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23378393
97Ovarian steroidogenesis_Homo sapiens_hsa049130.19501033
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16884378
99Glutathione metabolism_Homo sapiens_hsa004800.16286324
100Serotonergic synapse_Homo sapiens_hsa047260.15937296

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