RPL10L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of retinoic acid receptor signaling pathway (GO:0048385)9.90126949
2response to gravity (GO:0009629)7.24610611
3skeletal muscle tissue regeneration (GO:0043403)5.90901568
4piRNA metabolic process (GO:0034587)5.84831013
5striated muscle atrophy (GO:0014891)5.76583913
6synaptonemal complex assembly (GO:0007130)5.44707291
7regulation of skeletal muscle contraction (GO:0014819)5.39244870
8muscle atrophy (GO:0014889)5.36890771
9skeletal muscle adaptation (GO:0043501)5.33144591
10synaptonemal complex organization (GO:0070193)5.11682458
11ribosomal small subunit assembly (GO:0000028)4.86773418
12mitotic metaphase plate congression (GO:0007080)4.73332729
13DNA replication checkpoint (GO:0000076)4.55156875
14purine nucleobase biosynthetic process (GO:0009113)4.55100909
15DNA methylation involved in gamete generation (GO:0043046)4.49919229
16chaperone-mediated protein transport (GO:0072321)4.31334286
17nucleobase biosynthetic process (GO:0046112)4.30629077
18negative regulation of muscle hypertrophy (GO:0014741)4.26483204
19ribosome assembly (GO:0042255)4.24689924
20male meiosis (GO:0007140)4.19650002
21ribosome biogenesis (GO:0042254)4.19518315
22DNA replication initiation (GO:0006270)4.16775317
23viral transcription (GO:0019083)4.12177653
24nuclear pore organization (GO:0006999)4.11950320
25DNA replication-dependent nucleosome assembly (GO:0006335)4.10688875
26DNA replication-dependent nucleosome organization (GO:0034723)4.10688875
27chromosome organization involved in meiosis (GO:0070192)4.09372951
28meiotic nuclear division (GO:0007126)4.01833667
29pseudouridine synthesis (GO:0001522)3.96238279
30translational termination (GO:0006415)3.95541420
31maturation of SSU-rRNA (GO:0030490)3.94007887
32metaphase plate congression (GO:0051310)3.93078280
33translational elongation (GO:0006414)3.90505179
34formation of translation preinitiation complex (GO:0001731)3.88330411
35chromatin remodeling at centromere (GO:0031055)3.86273005
36male meiosis I (GO:0007141)3.85695848
37nuclear pore complex assembly (GO:0051292)3.85026568
38response to muscle activity (GO:0014850)3.84451311
39protein K6-linked ubiquitination (GO:0085020)3.77258106
40DNA deamination (GO:0045006)3.75648572
41histone exchange (GO:0043486)3.74714547
42regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.74352565
43regulation of meiosis I (GO:0060631)3.72034742
44kinetochore assembly (GO:0051382)3.70440177
45meiosis I (GO:0007127)3.69281666
46actin-myosin filament sliding (GO:0033275)3.68262088
47muscle filament sliding (GO:0030049)3.68262088
48kinetochore organization (GO:0051383)3.68181108
49DNA strand elongation involved in DNA replication (GO:0006271)3.66970226
50mitotic nuclear envelope disassembly (GO:0007077)3.66203108
51cellular component biogenesis (GO:0044085)3.64924263
52protein localization to chromosome, centromeric region (GO:0071459)3.64330421
53ribonucleoprotein complex biogenesis (GO:0022613)3.64300400
54positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.64251775
55histone H3-K9 demethylation (GO:0033169)3.63003831
56CENP-A containing nucleosome assembly (GO:0034080)3.59450711
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59126717
58regulation of posttranscriptional gene silencing (GO:0060147)3.58272910
59regulation of gene silencing by miRNA (GO:0060964)3.58272910
60regulation of gene silencing by RNA (GO:0060966)3.58272910
61regulation of spindle organization (GO:0090224)3.57568588
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51421341
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.51421341
64NADH dehydrogenase complex assembly (GO:0010257)3.51421341
65positive regulation of prostaglandin secretion (GO:0032308)3.49872183
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49262596
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46520696
68protein localization to kinetochore (GO:0034501)3.45998306
69DNA strand elongation (GO:0022616)3.45714427
70translational initiation (GO:0006413)3.43112300
71DNA replication-independent nucleosome organization (GO:0034724)3.42641843
72DNA replication-independent nucleosome assembly (GO:0006336)3.42641843
73meiotic cell cycle process (GO:1903046)3.42565778
74rRNA modification (GO:0000154)3.42328645
75attachment of spindle microtubules to kinetochore (GO:0008608)3.41602085
76meiotic chromosome segregation (GO:0045132)3.41335579
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40463859
78nuclear envelope disassembly (GO:0051081)3.39663355
79membrane disassembly (GO:0030397)3.39663355
80protein complex biogenesis (GO:0070271)3.37908974
81reciprocal meiotic recombination (GO:0007131)3.36857740
82reciprocal DNA recombination (GO:0035825)3.36857740
83mitotic sister chromatid segregation (GO:0000070)3.34648416
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.34472011
85mitochondrial respiratory chain complex assembly (GO:0033108)3.32966942
86multicellular organism reproduction (GO:0032504)3.31597906
87cotranslational protein targeting to membrane (GO:0006613)3.31168953
88regulation of nuclear cell cycle DNA replication (GO:0033262)3.31106109
89spliceosomal snRNP assembly (GO:0000387)3.29736122
90protein targeting to ER (GO:0045047)3.28101466
91telomere maintenance via semi-conservative replication (GO:0032201)3.27286302
92folic acid metabolic process (GO:0046655)3.26915837
93establishment of chromosome localization (GO:0051303)3.25886836
94* translation (GO:0006412)3.25741329
95IMP biosynthetic process (GO:0006188)3.25375905
96microtubule depolymerization (GO:0007019)3.24637037
97rRNA processing (GO:0006364)3.24388623
98regulation of chromosome segregation (GO:0051983)3.23857786
99chaperone-mediated protein complex assembly (GO:0051131)3.23716240
100regulation of histone H3-K9 methylation (GO:0051570)3.23537404
101somatic hypermutation of immunoglobulin genes (GO:0016446)3.23363268
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23363268
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.19319936
104positive regulation of chromosome segregation (GO:0051984)3.19090102
105binding of sperm to zona pellucida (GO:0007339)3.18072387
106positive regulation of protein homooligomerization (GO:0032464)3.17538162
107DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.17477573
108rRNA metabolic process (GO:0016072)3.16947151
109spermatid development (GO:0007286)3.16340796
110regulation of DNA methylation (GO:0044030)3.16133940
111protein polyglutamylation (GO:0018095)3.14553935
112protein localization to endoplasmic reticulum (GO:0070972)3.14144656
113regulation of helicase activity (GO:0051095)3.13518923
114transcription from RNA polymerase I promoter (GO:0006360)3.13233300
115regulation of centrosome cycle (GO:0046605)3.12887213
116protein targeting to mitochondrion (GO:0006626)3.12717005
117regulation of mitotic spindle organization (GO:0060236)3.12494016
118transcription from mitochondrial promoter (GO:0006390)3.11671030
119proteasome assembly (GO:0043248)3.11658333
120fusion of sperm to egg plasma membrane (GO:0007342)3.11483944
121establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11287110
122regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.10304020
123ribosomal large subunit biogenesis (GO:0042273)3.10134468
124actin-mediated cell contraction (GO:0070252)3.10088216
125negative regulation of chromosome segregation (GO:0051985)3.09742521
126termination of RNA polymerase I transcription (GO:0006363)3.07017949
127pore complex assembly (GO:0046931)3.06271711
128blastocyst development (GO:0001824)3.05616433
129viral life cycle (GO:0019058)3.05247753
130regulation of mitochondrial translation (GO:0070129)3.05140621
131termination of RNA polymerase III transcription (GO:0006386)3.04666847
132transcription elongation from RNA polymerase III promoter (GO:0006385)3.04666847
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04631378
134sperm-egg recognition (GO:0035036)3.04087595
135transcription elongation from RNA polymerase I promoter (GO:0006362)3.02423426
136GTP biosynthetic process (GO:0006183)3.02417230
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02167585
138negative regulation of sister chromatid segregation (GO:0033046)3.02167585
139negative regulation of mitotic sister chromatid separation (GO:2000816)3.02167585
140negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02167585
141telomere maintenance via recombination (GO:0000722)3.01545261
142spindle checkpoint (GO:0031577)3.00772733
143regulation of centriole replication (GO:0046599)2.98657335
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.98498317
145ribosomal small subunit biogenesis (GO:0042274)2.97984346
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97629086
147response to activity (GO:0014823)2.97529715
148maturation of 5.8S rRNA (GO:0000460)2.96803623
149gene silencing by RNA (GO:0031047)2.96246931
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95269780
151cellular protein complex disassembly (GO:0043624)2.95077261
152DNA damage response, signal transduction resulting in transcription (GO:0042772)2.93665190
153regulation of G0 to G1 transition (GO:0070316)2.91344863
154ncRNA processing (GO:0034470)2.90917030
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88747938
156positive regulation of histone H3-K4 methylation (GO:0051571)2.87057791
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85757542
158regulation of female receptivity (GO:0045924)2.82442202
159positive regulation of meiosis (GO:0045836)2.80841914
160establishment of protein localization to mitochondrion (GO:0072655)2.79664936
161rRNA methylation (GO:0031167)2.78826938
162positive regulation of meiotic cell cycle (GO:0051446)2.76235879
163autophagic vacuole assembly (GO:0000045)2.73035225
164behavioral response to nicotine (GO:0035095)2.71557216
165guanosine-containing compound biosynthetic process (GO:1901070)2.71297902
166protein localization to mitochondrion (GO:0070585)2.69727010
167tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69246217
168RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69246217
169protein-cofactor linkage (GO:0018065)2.68560494
170UTP biosynthetic process (GO:0006228)2.67800179
171response to electrical stimulus (GO:0051602)2.66903324
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66655602
173ATP synthesis coupled proton transport (GO:0015986)2.66655602
174transcription from RNA polymerase III promoter (GO:0006383)2.66204677
175positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65751113
176myoblast migration (GO:0051451)2.65279744
177negative regulation of skeletal muscle tissue development (GO:0048642)2.65246121
178negative regulation of retinoic acid receptor signaling pathway (GO:0048387)11.3862839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94656229
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.53721821
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.40404934
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.06491868
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.05465872
6VDR_22108803_ChIP-Seq_LS180_Human3.99100903
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.52105850
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.29554730
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19014446
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13770151
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.85546487
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81902853
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76770763
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74805815
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74301520
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70072231
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.69996418
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.68957367
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58118149
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56430443
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.45437326
22EZH2_22144423_ChIP-Seq_EOC_Human2.43222448
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.43134871
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39336401
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33178561
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31461175
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31461175
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31461175
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30196800
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30139171
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20365474
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.19859884
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.18177491
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15558325
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11835119
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11140849
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04423322
38XRN2_22483619_ChIP-Seq_HELA_Human2.03792087
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02201719
40AR_21909140_ChIP-Seq_LNCAP_Human2.01788854
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97539538
42VDR_23849224_ChIP-Seq_CD4+_Human1.94451705
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88780645
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87859345
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.86800081
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86766262
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81143820
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.77955949
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73992879
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71434274
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67506384
52TP53_22573176_ChIP-Seq_HFKS_Human1.66900094
53DCP1A_22483619_ChIP-Seq_HELA_Human1.65453252
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63512455
55GABP_19822575_ChIP-Seq_HepG2_Human1.63407558
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62875502
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62132690
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61087286
59ZNF274_21170338_ChIP-Seq_K562_Hela1.60073041
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.58686343
61IRF1_19129219_ChIP-ChIP_H3396_Human1.57455420
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56036764
63FOXP3_21729870_ChIP-Seq_TREG_Human1.55304001
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55111376
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52447170
66MYC_18940864_ChIP-ChIP_HL60_Human1.51806018
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50905791
68TTF2_22483619_ChIP-Seq_HELA_Human1.50404659
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45864560
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43137033
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43117600
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42154964
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37855556
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35497178
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35472488
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34756075
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33822501
78KDM5A_27292631_Chip-Seq_BREAST_Human1.31193020
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31120998
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24772780
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24534385
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23552732
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20141574
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19427471
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.16303569
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15522518
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15234010
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.15151995
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15082196
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14857581
91ELK1_19687146_ChIP-ChIP_HELA_Human1.14091712
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12733213
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11408169
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10217245
95SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09929745
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.09640648
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09610497
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07141943
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06942655
100ELF5_23300383_ChIP-Seq_T47D_Human1.06831804
101TAF15_26573619_Chip-Seq_HEK293_Human1.05703867
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.04232803
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02530068
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.01892218
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01336711
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01299046
107CIITA_25753668_ChIP-Seq_RAJI_Human1.01261551
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01041564
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00604806
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00182137
111KAP1_27257070_Chip-Seq_ESCs_Mouse0.99491870
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98231065
113* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98004105
114NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97213113
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97201679
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96709926
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96615276
118ZNF263_19887448_ChIP-Seq_K562_Human0.95401767
119STAT1_20625510_ChIP-Seq_HELA_Human0.94963819
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94791571
121POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94236985
122CTCF_20526341_ChIP-Seq_ESCs_Human0.94097587
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93942782
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93922889
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91571941
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91378731
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91296127
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90045681
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.89855219
130RAC3_21632823_ChIP-Seq_H3396_Human0.89686950
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89652020
132MYC_19829295_ChIP-Seq_ESCs_Human0.89402429
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.89294979
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86423645
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86055876
136TFEB_21752829_ChIP-Seq_HELA_Human0.85445620
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85040692
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.84664603
139RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84383958
140NCOR_22424771_ChIP-Seq_293T_Human0.83224186
141LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82834289
142* ERA_21632823_ChIP-Seq_H3396_Human0.82288179
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78710293
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.78356742
145NANOG_20526341_ChIP-Seq_ESCs_Human0.77844820
146FOXP1_21924763_ChIP-Seq_HESCs_Human0.77814799
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.76817293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43351879
2MP0008877_abnormal_DNA_methylation4.65860556
3MP0003111_abnormal_nucleus_morphology4.60571530
4MP0010094_abnormal_chromosome_stability4.45780810
5MP0004957_abnormal_blastocyst_morpholog4.36987553
6MP0008057_abnormal_DNA_replication4.19818534
7MP0008058_abnormal_DNA_repair3.76172805
8MP0003077_abnormal_cell_cycle3.61514127
9MP0004145_abnormal_muscle_electrophysio3.51964217
10MP0005410_abnormal_fertilization3.44522279
11MP0009379_abnormal_foot_pigmentation3.19429386
12MP0002138_abnormal_hepatobiliary_system3.17723111
13MP0000747_muscle_weakness2.92390667
14MP0002210_abnormal_sex_determination2.86259486
15MP0003786_premature_aging2.85664890
16MP0001929_abnormal_gametogenesis2.81549892
17MP0001986_abnormal_taste_sensitivity2.62946153
18MP0003718_maternal_effect2.57917089
19MP0003806_abnormal_nucleotide_metabolis2.57794138
20MP0008932_abnormal_embryonic_tissue2.52564070
21MP0003123_paternal_imprinting2.49407913
22MP0005423_abnormal_somatic_nervous2.46971129
23MP0008007_abnormal_cellular_replicative2.44863571
24MP0001145_abnormal_male_reproductive2.44387551
25MP0002089_abnormal_postnatal_growth/wei2.44370224
26MP0001730_embryonic_growth_arrest2.43288184
27MP0003698_abnormal_male_reproductive2.38924279
28MP0002653_abnormal_ependyma_morphology2.33191519
29MP0002277_abnormal_respiratory_mucosa2.14658575
30MP0000653_abnormal_sex_gland2.12546644
31MP0000350_abnormal_cell_proliferation2.08630628
32MP0001968_abnormal_touch/_nociception1.97102725
33MP0010307_abnormal_tumor_latency1.85721341
34MP0004036_abnormal_muscle_relaxation1.82146868
35MP0008995_early_reproductive_senescence1.77525507
36MP0005380_embryogenesis_phenotype1.76423813
37MP0001672_abnormal_embryogenesis/_devel1.76423813
38MP0000372_irregular_coat_pigmentation1.75907274
39MP0005083_abnormal_biliary_tract1.72849616
40MP0002736_abnormal_nociception_after1.68071217
41MP0000049_abnormal_middle_ear1.66285381
42MP0003950_abnormal_plasma_membrane1.64408913
43MP0004133_heterotaxia1.61932933
44MP0001697_abnormal_embryo_size1.61382836
45MP0000427_abnormal_hair_cycle1.59840899
46MP0002085_abnormal_embryonic_tissue1.59579447
47MP0010352_gastrointestinal_tract_polyps1.57236913
48MP0002160_abnormal_reproductive_system1.54462600
49MP0002161_abnormal_fertility/fecundity1.53969528
50MP0003941_abnormal_skin_development1.50680536
51MP0002080_prenatal_lethality1.47580673
52MP0003984_embryonic_growth_retardation1.46576434
53MP0002084_abnormal_developmental_patter1.45959596
54MP0005646_abnormal_pituitary_gland1.43506991
55MP0002088_abnormal_embryonic_growth/wei1.42088314
56MP0003136_yellow_coat_color1.40529079
57MP0000759_abnormal_skeletal_muscle1.40515604
58MP0003938_abnormal_ear_development1.39243601
59MP0000749_muscle_degeneration1.38235138
60MP0003959_abnormal_lean_body1.36054181
61MP0004197_abnormal_fetal_growth/weight/1.34218659
62MP0002095_abnormal_skin_pigmentation1.33234845
63MP0002106_abnormal_muscle_physiology1.32204996
64MP0001502_abnormal_circadian_rhythm1.31343487
65MP0008872_abnormal_physiological_respon1.30297874
66MP0002086_abnormal_extraembryonic_tissu1.30272697
67MP0001293_anophthalmia1.27848562
68MP0005645_abnormal_hypothalamus_physiol1.26703965
69MP0000313_abnormal_cell_death1.23800164
70MP0008789_abnormal_olfactory_epithelium1.23566287
71MP0003315_abnormal_perineum_morphology1.22837940
72MP0004142_abnormal_muscle_tone1.22518968
73MP0003119_abnormal_digestive_system1.20787426
74MP0002108_abnormal_muscle_morphology1.13258040
75MP0005389_reproductive_system_phenotype1.12265668
76MP0008875_abnormal_xenobiotic_pharmacok1.11293942
77MP0001119_abnormal_female_reproductive1.10418137
78MP0005620_abnormal_muscle_contractility1.04917881
79MP0003890_abnormal_embryonic-extraembry1.04886225
80MP0001905_abnormal_dopamine_level1.04292584
81MP0000678_abnormal_parathyroid_gland1.03496289
82MP0005395_other_phenotype1.02402504
83MP0003567_abnormal_fetal_cardiomyocyte1.02349588
84MP0005369_muscle_phenotype1.02197421
85MP0005377_hearing/vestibular/ear_phenot1.01762644
86MP0003878_abnormal_ear_physiology1.01762644
87MP0004885_abnormal_endolymph1.00882126
88MP0002102_abnormal_ear_morphology1.00859605
89MP0002019_abnormal_tumor_incidence0.99089610
90MP0006072_abnormal_retinal_apoptosis0.98275094
91MP0003186_abnormal_redox_activity0.97200809
92MP0000358_abnormal_cell_content/0.95291826
93MP0006292_abnormal_olfactory_placode0.93468576
94MP0009250_abnormal_appendicular_skeleto0.92352760
95MP0004087_abnormal_muscle_fiber0.92161725
96MP0005076_abnormal_cell_differentiation0.91967512
97MP0003699_abnormal_female_reproductive0.89868100
98MP0000631_abnormal_neuroendocrine_gland0.87487150
99MP0008260_abnormal_autophagy0.85564170
100MP0003936_abnormal_reproductive_system0.84493113
101MP0005266_abnormal_metabolism0.82879034
102MP0005551_abnormal_eye_electrophysiolog0.82689009
103MP0003283_abnormal_digestive_organ0.80046007
104MP0003121_genomic_imprinting0.79887535
105MP0000733_abnormal_muscle_development0.79580308
106MP0000490_abnormal_crypts_of0.79485590
107MP0002272_abnormal_nervous_system0.79282340
108MP0005394_taste/olfaction_phenotype0.77865750
109MP0005499_abnormal_olfactory_system0.77865750
110MP0000516_abnormal_urinary_system0.77535675
111MP0005367_renal/urinary_system_phenotyp0.77535675
112MP0003646_muscle_fatigue0.77355598
113MP0005670_abnormal_white_adipose0.76623046
114MP0001661_extended_life_span0.74224810
115MP0006276_abnormal_autonomic_nervous0.73912741
116MP0002163_abnormal_gland_morphology0.73763128
117MP0002184_abnormal_innervation0.73719694
118MP0005384_cellular_phenotype0.73192202
119MP0001881_abnormal_mammary_gland0.73043339
120MP0009672_abnormal_birth_weight0.72560474
121MP0002837_dystrophic_cardiac_calcinosis0.72251093
122MP0001835_abnormal_antigen_presentation0.69264311
123MP0002876_abnormal_thyroid_physiology0.69034212
124MP0002735_abnormal_chemical_nociception0.68631610
125MP0005621_abnormal_cell_physiology0.68615932
126MP0009703_decreased_birth_body0.68424505
127MP0001348_abnormal_lacrimal_gland0.67788451
128MP0000613_abnormal_salivary_gland0.67141309
129MP0001849_ear_inflammation0.66617406
130MP0000750_abnormal_muscle_regeneration0.65368061
131MP0005647_abnormal_sex_gland0.64919163
132MP0002332_abnormal_exercise_endurance0.64533211
133MP0002751_abnormal_autonomic_nervous0.64153619
134MP0006035_abnormal_mitochondrial_morpho0.63515339
135MP0000470_abnormal_stomach_morphology0.63314620
136MP0002269_muscular_atrophy0.62116836
137MP0000647_abnormal_sebaceous_gland0.61838100
138MP0002111_abnormal_tail_morphology0.61679112
139MP0004233_abnormal_muscle_weight0.61310012
140MP0002092_abnormal_eye_morphology0.61062687
141MP0001919_abnormal_reproductive_system0.60339691
142MP0004808_abnormal_hematopoietic_stem0.58718232
143MP0006036_abnormal_mitochondrial_physio0.58431692
144MP0003937_abnormal_limbs/digits/tail_de0.58264912
145MP0005397_hematopoietic_system_phenotyp0.57730230
146MP0001545_abnormal_hematopoietic_system0.57730230
147MP0001286_abnormal_eye_development0.57459825
148MP0010030_abnormal_orbit_morphology0.55415597
149MP0003861_abnormal_nervous_system0.55006250
150MP0001727_abnormal_embryo_implantation0.54559673
151MP0009053_abnormal_anal_canal0.53283865
152MP0000432_abnormal_head_morphology0.53210443
153MP0003221_abnormal_cardiomyocyte_apopto0.52915155
154MP0002396_abnormal_hematopoietic_system0.52553518
155MP0005023_abnormal_wound_healing0.52203705
156MP0000537_abnormal_urethra_morphology0.47962100
157MP0009840_abnormal_foam_cell0.47660972
158MP0002127_abnormal_cardiovascular_syste0.46613731
159MP0000627_abnormal_mammary_gland0.45566741
160MP0009333_abnormal_splenocyte_physiolog0.45070573

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.76815447
2Breast hypoplasia (HP:0003187)5.62766530
3Impulsivity (HP:0100710)4.59259234
4Palpebral edema (HP:0100540)4.55280441
5Abnormality of the anterior horn cell (HP:0006802)4.37756950
6Degeneration of anterior horn cells (HP:0002398)4.37756950
7Carpal bone hypoplasia (HP:0001498)4.33821924
8Abnormality of the labia minora (HP:0012880)3.99877195
9Acute necrotizing encephalopathy (HP:0006965)3.94183492
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.82430112
11Abnormal spermatogenesis (HP:0008669)3.60982379
12Supernumerary spleens (HP:0009799)3.58490656
13Mitochondrial inheritance (HP:0001427)3.55124164
14Absent radius (HP:0003974)3.54093814
15Cerebral hypomyelination (HP:0006808)3.50506093
16Increased CSF lactate (HP:0002490)3.49923305
17Patellar aplasia (HP:0006443)3.49600921
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.46349751
19Abnormal mitochondria in muscle tissue (HP:0008316)3.45821733
20Ependymoma (HP:0002888)3.41349501
21Mask-like facies (HP:0000298)3.35904708
22Aplasia involving forearm bones (HP:0009822)3.34311234
23Absent forearm bone (HP:0003953)3.34311234
24Absent phalangeal crease (HP:0006109)3.32099965
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.30963354
26Chromsome breakage (HP:0040012)3.30012211
27Increased hepatocellular lipid droplets (HP:0006565)3.27822134
28Aplasia/Hypoplasia of the patella (HP:0006498)3.27768428
29Progressive macrocephaly (HP:0004481)3.22955151
30Absent thumb (HP:0009777)3.17482599
31Azoospermia (HP:0000027)3.17256347
32Nemaline bodies (HP:0003798)3.17237821
33Selective tooth agenesis (HP:0001592)3.12963110
34Renal Fanconi syndrome (HP:0001994)3.10768838
35Absent/shortened dynein arms (HP:0200106)3.09154258
36Dynein arm defect of respiratory motile cilia (HP:0012255)3.09154258
37Acute encephalopathy (HP:0006846)3.09003425
38Meckel diverticulum (HP:0002245)3.07229389
39Premature ovarian failure (HP:0008209)3.05580083
40Myopathic facies (HP:0002058)3.02305692
41Distal arthrogryposis (HP:0005684)3.02064238
42Rough bone trabeculation (HP:0100670)2.95606250
43Testicular atrophy (HP:0000029)2.94799272
44Aplasia/hypoplasia of the humerus (HP:0006507)2.92892704
45Short tibia (HP:0005736)2.91447631
46Abnormality of the ileum (HP:0001549)2.91413491
47Microretrognathia (HP:0000308)2.89204422
48Lipid accumulation in hepatocytes (HP:0006561)2.86672063
49Abnormality of the preputium (HP:0100587)2.86049989
50Reticulocytopenia (HP:0001896)2.84380608
51Ulnar deviation of the wrist (HP:0003049)2.83212300
52Microglossia (HP:0000171)2.80975410
533-Methylglutaconic aciduria (HP:0003535)2.78786006
54Round ear (HP:0100830)2.76941373
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.76420978
56Abnormality of chromosome stability (HP:0003220)2.76296399
57Hepatocellular necrosis (HP:0001404)2.75588888
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74918019
59Abnormality of the lower motor neuron (HP:0002366)2.73606160
60Fibular aplasia (HP:0002990)2.72559670
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.72208967
62Aplasia/hypoplasia of the uterus (HP:0008684)2.68491410
63Oral leukoplakia (HP:0002745)2.65256252
64Abnormal respiratory epithelium morphology (HP:0012253)2.64907079
65Abnormal respiratory motile cilium morphology (HP:0005938)2.64907079
66Increased serum lactate (HP:0002151)2.62459876
67Abnormal finger flexion creases (HP:0006143)2.61169090
68Horseshoe kidney (HP:0000085)2.60300425
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.56793352
70Hyperkalemia (HP:0002153)2.52458542
71Hypoplasia of the uterus (HP:0000013)2.52223532
72Abnormality of cells of the erythroid lineage (HP:0012130)2.51594116
73Pendular nystagmus (HP:0012043)2.50921968
74Medulloblastoma (HP:0002885)2.50591177
75Conjunctival hamartoma (HP:0100780)2.48345865
76Short humerus (HP:0005792)2.48006894
77Adrenal hypoplasia (HP:0000835)2.47006277
78Hepatic necrosis (HP:0002605)2.46235008
79Concave nail (HP:0001598)2.44987881
80Rhabdomyosarcoma (HP:0002859)2.43198446
81Pancreatic fibrosis (HP:0100732)2.42837263
82Agnosia (HP:0010524)2.41227783
83Muscle fiber inclusion bodies (HP:0100299)2.40886852
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39482137
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39107996
86Colon cancer (HP:0003003)2.38496914
87Hyperglycinemia (HP:0002154)2.37361229
88Ureteral duplication (HP:0000073)2.36706522
89Duplicated collecting system (HP:0000081)2.34032825
90Abnormal number of erythroid precursors (HP:0012131)2.31593056
91Exertional dyspnea (HP:0002875)2.30922706
92Rhinitis (HP:0012384)2.30432715
93Pancreatic cysts (HP:0001737)2.28239766
94Delayed CNS myelination (HP:0002188)2.27988965
95Hypoplasia of the radius (HP:0002984)2.27053881
96Exercise-induced myalgia (HP:0003738)2.27032189
97Small intestinal stenosis (HP:0012848)2.26830984
98Duodenal stenosis (HP:0100867)2.26830984
99Reduced antithrombin III activity (HP:0001976)2.26335124
100Abnormality of abdominal situs (HP:0011620)2.26172350
101Abdominal situs inversus (HP:0003363)2.26172350
102Type I transferrin isoform profile (HP:0003642)2.26004093
103Chronic bronchitis (HP:0004469)2.25526641
104Secondary amenorrhea (HP:0000869)2.25186169
105Abnormal respiratory motile cilium physiology (HP:0012261)2.24653279
106Rectovaginal fistula (HP:0000143)2.24441367
107Rectal fistula (HP:0100590)2.24441367
108Facial hemangioma (HP:0000329)2.24267696
109Abnormal rod and cone electroretinograms (HP:0008323)2.23488333
110Maternal diabetes (HP:0009800)2.23393864
111Decreased circulating renin level (HP:0003351)2.23296936
112Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23207897
113Facial cleft (HP:0002006)2.22779858
114Abnormality of the astrocytes (HP:0100707)2.22769222
115Astrocytoma (HP:0009592)2.22769222
116Trismus (HP:0000211)2.22225553
117Exercise intolerance (HP:0003546)2.22053744
118Periorbital edema (HP:0100539)2.21091595
119Aplasia/Hypoplasia of the tongue (HP:0010295)2.20614873
120Posterior subcapsular cataract (HP:0007787)2.19963689
121Respiratory difficulties (HP:0002880)2.18294821
122Neoplasm of the pancreas (HP:0002894)2.18120185
123Spinal muscular atrophy (HP:0007269)2.16443648
124Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15950916
125Cerebral edema (HP:0002181)2.15775186
126Sloping forehead (HP:0000340)2.15618299
127Facial edema (HP:0000282)2.15335241
128Multiple enchondromatosis (HP:0005701)2.15173639
129Breast aplasia (HP:0100783)2.14392419
130Abnormality of alanine metabolism (HP:0010916)2.13909392
131Hyperalaninemia (HP:0003348)2.13909392
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13909392
133Glioma (HP:0009733)2.13732070
134Lactic acidosis (HP:0003128)2.13284326
135Bone marrow hypocellularity (HP:0005528)2.13088473
136Median cleft lip (HP:0000161)2.12518939
137Hyperphosphatemia (HP:0002905)2.11178754
138Shawl scrotum (HP:0000049)2.10342919
139CNS hypomyelination (HP:0003429)2.09415499
140Cleft eyelid (HP:0000625)2.08771183
141Abnormal trabecular bone morphology (HP:0100671)2.08076815
142Ectopic kidney (HP:0000086)2.07330201
143Molar tooth sign on MRI (HP:0002419)2.06333274
144Abnormality of midbrain morphology (HP:0002418)2.06333274
145Stenosis of the external auditory canal (HP:0000402)2.05998363
146Increased intramyocellular lipid droplets (HP:0012240)2.05375976
147Prostate neoplasm (HP:0100787)2.04941922
148Personality changes (HP:0000751)2.04406883
149Male infertility (HP:0003251)2.04350905
150Reduced subcutaneous adipose tissue (HP:0003758)2.03380563
151Aplasia/Hypoplasia of the breasts (HP:0010311)2.03284210
152Hyperglycinuria (HP:0003108)2.02305246
153Triphalangeal thumb (HP:0001199)2.01451116
154Oligodactyly (HP:0012165)2.00538211
155Short thumb (HP:0009778)2.00442379
156Progressive muscle weakness (HP:0003323)1.97765129
157Neoplasm of the oral cavity (HP:0100649)1.97637842
158Squamous cell carcinoma (HP:0002860)1.97016437
159Infertility (HP:0000789)1.96682973
160Tracheoesophageal fistula (HP:0002575)1.95601729
161Abnormality of the nasal septum (HP:0000419)1.95587364
162Amyotrophic lateral sclerosis (HP:0007354)1.93040842
163Congenital stationary night blindness (HP:0007642)1.92323069
164Gonadotropin excess (HP:0000837)1.92299048
165Optic disc pallor (HP:0000543)1.91567957
166Myelodysplasia (HP:0002863)1.91249828
167Symphalangism affecting the phalanges of the hand (HP:0009773)1.90531195
168Abnormal number of incisors (HP:0011064)1.89691561
169Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89425122
170Premature graying of hair (HP:0002216)1.89003500
171Abnormality of the duodenum (HP:0002246)1.88807884
172Abnormality of the pons (HP:0007361)1.88344237
173Biliary tract neoplasm (HP:0100574)1.87707815
174Tongue fasciculations (HP:0001308)1.86939732
175Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86248957
176Abnormal protein N-linked glycosylation (HP:0012347)1.86248957
177Abnormal protein glycosylation (HP:0012346)1.86248957
178Abnormal glycosylation (HP:0012345)1.86248957
179Fused cervical vertebrae (HP:0002949)1.85290316
180Abnormality of renal resorption (HP:0011038)1.85262141
181Congenital, generalized hypertrichosis (HP:0004540)1.82743110
182Calcaneovalgus deformity (HP:0001848)1.81937265
183Deformed tarsal bones (HP:0008119)1.81595874
184Hamartoma of the eye (HP:0010568)1.80267541
185Hyperglycemia (HP:0003074)1.79984205
186Forearm undergrowth (HP:0009821)1.79090257
187Severe muscular hypotonia (HP:0006829)1.78412581
188Hypoplasia of the pons (HP:0012110)1.77897720
189Insulin-resistant diabetes mellitus (HP:0000831)1.77531266
190Opisthotonus (HP:0002179)1.76804994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.63644255
2BUB14.40877872
3VRK24.06380946
4PDK43.61429720
5PDK33.61429720
6CDC73.39790419
7TIE13.32474988
8NEK23.01016979
9WNK42.87068437
10PHKG22.85578650
11PHKG12.85578650
12NUAK12.79592662
13TTK2.76952492
14PDK22.68425586
15EIF2AK12.57284119
16SRPK12.55954786
17PNCK2.36882354
18PLK42.33371391
19EPHA22.33274409
20PLK12.27052832
21AKT32.23800792
22NEK12.23216949
23CDK121.98979293
24STK391.93974899
25ACVR1B1.92604732
26WNK11.88924653
27DYRK31.85064540
28TSSK61.83306145
29BMPR1B1.72413549
30STK38L1.72387809
31LIMK11.72263518
32BRSK21.61803186
33MKNK21.61157525
34PLK31.60768881
35CDK71.59245903
36MAP4K21.55919306
37TESK11.55822157
38CHEK21.55592972
39TESK21.54972614
40OBSCN1.50803399
41EIF2AK31.48455987
42NME21.45995603
43RPS6KB21.43480148
44ATR1.43352605
45STK161.42286170
46MKNK11.41997096
47TEC1.41744601
48AURKB1.40971401
49GRK11.39625117
50AURKA1.36535189
51CDK191.35875124
52CHEK11.29117982
53MUSK1.19936718
54VRK11.14539734
55TAF11.13278826
56PASK1.10398829
57LATS21.08352187
58CAMKK21.06319036
59BRSK11.05714248
60OXSR11.04874243
61CDK41.03334119
62ICK1.02525304
63CSNK1G10.99955738
64CCNB10.98762233
65MAPKAPK30.98421215
66ZAK0.97054265
67ADRBK20.96527198
68TLK10.96365680
69PAK40.94673412
70PIK3CA0.93388358
71ILK0.93050692
72CDK20.89159603
73MAP3K80.89108740
74LMTK20.88757491
75CDK80.87374493
76PIM20.86143775
77STK40.85973014
78ATM0.85924789
79BRAF0.85277219
80ALK0.84899134
81PRKCI0.81435032
82TAOK30.79248299
83STK30.75165847
84CSNK2A20.73091208
85CSNK1G30.72565921
86CSNK1G20.72461250
87DYRK20.71886462
88DAPK10.71543253
89PAK10.70242396
90PINK10.69594494
91MAP3K120.69420872
92STK380.68322198
93LRRK20.67744436
94ARAF0.67477325
95BCKDK0.67345783
96CSNK2A10.66704765
97RPS6KA40.64331143
98CAMK1D0.64299721
99CDK10.64271617
100EIF2AK20.61440413
101TXK0.61252092
102CSNK1A1L0.59419280
103CAMK2G0.59126879
104BRD40.59002252
105PIM10.58817683
106CDK90.57750511
107MELK0.57724635
108PBK0.57334462
109GRK50.57300712
110CSNK1E0.56175040
111JAK30.52666618
112PRKD30.50916855
113MTOR0.49983748
114MAPK130.49816518
115MET0.49023852
116TYRO30.42175332
117PAK60.41851752
118INSRR0.40217546
119CSNK1A10.39334580
120MAP2K70.38188044
121CDK60.36517829
122GRK70.36051696
123KDR0.35599428
124SCYL20.34112588
125CSNK1D0.31744892
126NME10.30883492
127WNK30.29894989
128RPS6KA50.29481244
129STK100.28788760
130PRKDC0.28251017
131PRKG10.27780724
132PRKACA0.25353363
133MOS0.25146585
134GSK3B0.25118313
135PKN10.24919807
136TNIK0.24496977
137PIK3CG0.23872803
138ITK0.23451276
139PRKACB0.23280513
140MAPK140.21526106
141IRAK30.20963074
142MARK30.20684423
143NEK60.19926609
144MAPK100.16982178
145STK240.15024198
146MAPK10.12121191
147MST40.10943755
148ABL20.10424594
149PRKAA10.10062356
150CDK30.09222638
151DYRK1B0.08656902
152AKT20.07413385
153MAP3K30.07155046
154MAPK80.07019830
155AKT10.06919202

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.58766543
2DNA replication_Homo sapiens_hsa030304.12823372
3RNA polymerase_Homo sapiens_hsa030203.92057435
4Mismatch repair_Homo sapiens_hsa034303.86112906
5RNA transport_Homo sapiens_hsa030133.62912168
6Proteasome_Homo sapiens_hsa030503.54431128
7Spliceosome_Homo sapiens_hsa030403.15233108
8Homologous recombination_Homo sapiens_hsa034402.89017202
9Basal transcription factors_Homo sapiens_hsa030222.82189939
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.78015131
11Nucleotide excision repair_Homo sapiens_hsa034202.70220536
12Fanconi anemia pathway_Homo sapiens_hsa034602.69238240
13* Ribosome_Homo sapiens_hsa030102.68409204
14Vitamin B6 metabolism_Homo sapiens_hsa007502.59276922
15Cell cycle_Homo sapiens_hsa041102.54875191
16Pyrimidine metabolism_Homo sapiens_hsa002402.53541077
17One carbon pool by folate_Homo sapiens_hsa006702.47017567
18Base excision repair_Homo sapiens_hsa034102.44537849
19Asthma_Homo sapiens_hsa053102.43994915
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28720138
21mRNA surveillance pathway_Homo sapiens_hsa030152.02022430
22RNA degradation_Homo sapiens_hsa030181.69521479
23Non-homologous end-joining_Homo sapiens_hsa034501.62885538
24Alzheimers disease_Homo sapiens_hsa050101.62492841
25Cardiac muscle contraction_Homo sapiens_hsa042601.61398448
26Purine metabolism_Homo sapiens_hsa002301.55718201
27Allograft rejection_Homo sapiens_hsa053301.54450637
28p53 signaling pathway_Homo sapiens_hsa041151.53845026
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.52620339
30Nitrogen metabolism_Homo sapiens_hsa009101.51056215
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47894837
32Selenocompound metabolism_Homo sapiens_hsa004501.43779800
33Autoimmune thyroid disease_Homo sapiens_hsa053201.41914464
34Oocyte meiosis_Homo sapiens_hsa041141.41526285
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.37648301
36Sulfur metabolism_Homo sapiens_hsa009201.30993833
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28061597
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27467878
39Pentose phosphate pathway_Homo sapiens_hsa000301.24478284
40Biosynthesis of amino acids_Homo sapiens_hsa012301.22446117
41Epstein-Barr virus infection_Homo sapiens_hsa051691.18056200
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17442632
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.17385690
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16770098
45Protein export_Homo sapiens_hsa030601.08881174
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96252052
47Folate biosynthesis_Homo sapiens_hsa007900.93457126
48Huntingtons disease_Homo sapiens_hsa050160.92399087
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.92138551
50Fructose and mannose metabolism_Homo sapiens_hsa000510.86636304
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85522751
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83848787
53Glutathione metabolism_Homo sapiens_hsa004800.79816803
54Carbon metabolism_Homo sapiens_hsa012000.79425224
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.79257747
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78352463
57Type I diabetes mellitus_Homo sapiens_hsa049400.78351159
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77751045
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76311771
60Regulation of autophagy_Homo sapiens_hsa041400.73633599
61Graft-versus-host disease_Homo sapiens_hsa053320.71391435
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70096476
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68754230
64Sulfur relay system_Homo sapiens_hsa041220.65504104
65Systemic lupus erythematosus_Homo sapiens_hsa053220.65105787
66Insulin secretion_Homo sapiens_hsa049110.61540061
67Linoleic acid metabolism_Homo sapiens_hsa005910.58666284
68Viral carcinogenesis_Homo sapiens_hsa052030.57361532
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56269984
70Antigen processing and presentation_Homo sapiens_hsa046120.55968896
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55156682
72Peroxisome_Homo sapiens_hsa041460.55100674
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53001369
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.52821167
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52301591
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50156237
77Herpes simplex infection_Homo sapiens_hsa051680.50137308
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49044740
79Phototransduction_Homo sapiens_hsa047440.48861593
80Pyruvate metabolism_Homo sapiens_hsa006200.45774526
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44969917
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44441157
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44006167
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42244858
85Chemical carcinogenesis_Homo sapiens_hsa052040.41402149
86Salivary secretion_Homo sapiens_hsa049700.40550400
87Metabolic pathways_Homo sapiens_hsa011000.39875142
88Hippo signaling pathway_Homo sapiens_hsa043900.39654849
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39587189
90Rheumatoid arthritis_Homo sapiens_hsa053230.39256962
91Arachidonic acid metabolism_Homo sapiens_hsa005900.37583762
92HTLV-I infection_Homo sapiens_hsa051660.37571922
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36481238
94Arginine and proline metabolism_Homo sapiens_hsa003300.33139958
95TGF-beta signaling pathway_Homo sapiens_hsa043500.32285085
96Hedgehog signaling pathway_Homo sapiens_hsa043400.31174974
97Thyroid cancer_Homo sapiens_hsa052160.30805167
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29139920
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27464743
100Olfactory transduction_Homo sapiens_hsa047400.26853806
101Retinol metabolism_Homo sapiens_hsa008300.25265934
102Basal cell carcinoma_Homo sapiens_hsa052170.24756279
103Calcium signaling pathway_Homo sapiens_hsa040200.24672431
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22656989
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22023577
106Vitamin digestion and absorption_Homo sapiens_hsa049770.21972239
107MicroRNAs in cancer_Homo sapiens_hsa052060.21945985
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21886021
109Oxytocin signaling pathway_Homo sapiens_hsa049210.21721649
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.21633980
111Caffeine metabolism_Homo sapiens_hsa002320.21463266
112Tight junction_Homo sapiens_hsa045300.21237952
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20539762
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20385537
115N-Glycan biosynthesis_Homo sapiens_hsa005100.19902053
116Fatty acid biosynthesis_Homo sapiens_hsa000610.19378698
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17846745
118mTOR signaling pathway_Homo sapiens_hsa041500.17714709
119Parkinsons disease_Homo sapiens_hsa050120.17394492
120Glycerolipid metabolism_Homo sapiens_hsa005610.16205134
121Galactose metabolism_Homo sapiens_hsa000520.15931771
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14981036
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14579655
124Viral myocarditis_Homo sapiens_hsa054160.14460776
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.14322362
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14055163
127HIF-1 signaling pathway_Homo sapiens_hsa040660.09897835
128Oxidative phosphorylation_Homo sapiens_hsa001900.08429786
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07916944
130Small cell lung cancer_Homo sapiens_hsa052220.07070661
131Renin-angiotensin system_Homo sapiens_hsa046140.06725521
132Propanoate metabolism_Homo sapiens_hsa006400.06701938
133Alcoholism_Homo sapiens_hsa050340.06525813
134Notch signaling pathway_Homo sapiens_hsa043300.06078781
135Fat digestion and absorption_Homo sapiens_hsa049750.05921567
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.04667263
137Legionellosis_Homo sapiens_hsa051340.03139630
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02808196
139Wnt signaling pathway_Homo sapiens_hsa043100.02252112
140Glucagon signaling pathway_Homo sapiens_hsa049220.01645411
141Ether lipid metabolism_Homo sapiens_hsa005650.01421803
142Mineral absorption_Homo sapiens_hsa04978-0.0252408
143Pathways in cancer_Homo sapiens_hsa05200-0.0072690

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