RPGRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell maintenance (GO:0045494)9.88655996
2GMP metabolic process (GO:0046037)9.51790259
3* photoreceptor cell development (GO:0042461)9.18992146
4retinal rod cell development (GO:0046548)9.03690405
5* eye photoreceptor cell development (GO:0042462)8.70891504
6detection of light stimulus involved in visual perception (GO:0050908)7.79079792
7detection of light stimulus involved in sensory perception (GO:0050962)7.79079792
8phototransduction (GO:0007602)7.21460741
9phototransduction, visible light (GO:0007603)6.98456274
10detection of light stimulus (GO:0009583)6.90465855
11detection of visible light (GO:0009584)6.76547452
12sulfation (GO:0051923)6.60136181
13* visual perception (GO:0007601)6.58634110
14* sensory perception of light stimulus (GO:0050953)6.51062063
15behavioral response to nicotine (GO:0035095)5.62262036
16* retina development in camera-type eye (GO:0060041)5.53762924
17protein-chromophore linkage (GO:0018298)5.49823609
18cellular response to light stimulus (GO:0071482)5.24873816
19cell proliferation in forebrain (GO:0021846)5.23015196
20eye photoreceptor cell differentiation (GO:0001754)5.18513386
21photoreceptor cell differentiation (GO:0046530)5.18513386
22DNA deamination (GO:0045006)5.02214044
23detection of external stimulus (GO:0009581)4.72893322
24detection of abiotic stimulus (GO:0009582)4.66008015
25otic vesicle formation (GO:0030916)4.53908710
26ribosomal small subunit assembly (GO:0000028)4.52173527
27positive regulation of guanylate cyclase activity (GO:0031284)4.32786088
28water-soluble vitamin biosynthetic process (GO:0042364)4.30167136
29nonmotile primary cilium assembly (GO:0035058)4.27592021
30negative regulation of mast cell activation (GO:0033004)4.18581470
31regulation of guanylate cyclase activity (GO:0031282)3.83686846
32cellular response to ATP (GO:0071318)3.83126536
33indole-containing compound catabolic process (GO:0042436)3.75817682
34indolalkylamine catabolic process (GO:0046218)3.75817682
35tryptophan catabolic process (GO:0006569)3.75817682
36negative regulation of systemic arterial blood pressure (GO:0003085)3.75025333
37cellular response to radiation (GO:0071478)3.69589502
38positive regulation of cAMP-mediated signaling (GO:0043950)3.63180204
39regulation of collateral sprouting (GO:0048670)3.61378567
40regulation of glomerulus development (GO:0090192)3.57788996
41regulation of posttranscriptional gene silencing (GO:0060147)3.50564608
42regulation of gene silencing by miRNA (GO:0060964)3.50564608
43regulation of gene silencing by RNA (GO:0060966)3.50564608
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49364962
45protein heterotetramerization (GO:0051290)3.46194513
46protein polyglutamylation (GO:0018095)3.42932454
47telomere maintenance via semi-conservative replication (GO:0032201)3.42434545
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.37322368
49NADH dehydrogenase complex assembly (GO:0010257)3.37322368
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37322368
51kynurenine metabolic process (GO:0070189)3.37313937
52indolalkylamine metabolic process (GO:0006586)3.35784368
53gamma-aminobutyric acid transport (GO:0015812)3.29261531
54transmission of nerve impulse (GO:0019226)3.27344443
55epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.24448800
56tryptophan metabolic process (GO:0006568)3.19784193
57axoneme assembly (GO:0035082)3.15352107
58negative regulation of telomere maintenance (GO:0032205)3.15227419
59prenylation (GO:0097354)3.13175867
60protein prenylation (GO:0018342)3.13175867
61viral transcription (GO:0019083)3.12222696
62retina homeostasis (GO:0001895)3.10633915
63* sensory perception (GO:0007600)3.09854782
64cytidine catabolic process (GO:0006216)3.06777617
65cytidine deamination (GO:0009972)3.06777617
66cytidine metabolic process (GO:0046087)3.06777617
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.04226424
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.03352495
693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.03352495
70retina layer formation (GO:0010842)3.02275146
71pharyngeal system development (GO:0060037)3.02062943
72telomere maintenance via recombination (GO:0000722)3.01760692
73negative regulation of appetite (GO:0032099)2.99294616
74negative regulation of response to food (GO:0032096)2.99294616
75limb bud formation (GO:0060174)2.96094788
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95517351
77protein complex biogenesis (GO:0070271)2.95407814
78regulation of cGMP metabolic process (GO:0030823)2.94645133
79translational termination (GO:0006415)2.93878570
80kidney morphogenesis (GO:0060993)2.92802227
81regulation of DNA endoreduplication (GO:0032875)2.91035997
82protein neddylation (GO:0045116)2.90966390
83regulation of action potential (GO:0098900)2.90479312
84lung morphogenesis (GO:0060425)2.89610312
85regulation of cell proliferation involved in kidney development (GO:1901722)2.86638040
86response to light stimulus (GO:0009416)2.85847521
87somite development (GO:0061053)2.84377355
88negative regulation by host of viral transcription (GO:0043922)2.84364878
89estrogen biosynthetic process (GO:0006703)2.83019332
90forebrain morphogenesis (GO:0048853)2.82947530
91ribosomal small subunit biogenesis (GO:0042274)2.82333969
92DNA strand elongation involved in DNA replication (GO:0006271)2.80946876
93protein localization to cilium (GO:0061512)2.80307393
94negative regulation of axon extension involved in axon guidance (GO:0048843)2.76944413
95guanosine-containing compound biosynthetic process (GO:1901070)2.75707412
96indole-containing compound metabolic process (GO:0042430)2.75354835
97regulation of phospholipid biosynthetic process (GO:0071071)2.74425064
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73483290
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.72894636
100spinal cord motor neuron differentiation (GO:0021522)2.71936543
101DNA strand elongation (GO:0022616)2.71336819
102N-acetylglucosamine metabolic process (GO:0006044)2.69582681
103embryonic hindlimb morphogenesis (GO:0035116)2.68098108
104positive regulation of fatty acid oxidation (GO:0046321)2.67776606
105pyrimidine ribonucleoside catabolic process (GO:0046133)2.67655581
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67574400
107dorsal/ventral axis specification (GO:0009950)2.66410670
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65438207
109mitotic recombination (GO:0006312)2.64120739
110amine catabolic process (GO:0009310)2.62616337
111cellular biogenic amine catabolic process (GO:0042402)2.62616337
112adaptation of signaling pathway (GO:0023058)2.62339457
113mitochondrial respiratory chain complex assembly (GO:0033108)2.62079473
114male meiosis I (GO:0007141)2.61629047
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61612836
116cell morphogenesis involved in neuron differentiation (GO:0048667)2.61447821
117cotranslational protein targeting to membrane (GO:0006613)2.61445091
118pituitary gland development (GO:0021983)2.60793567
119mannosylation (GO:0097502)2.60494706
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.59517811
121nephron tubule morphogenesis (GO:0072078)2.58929461
122nephron epithelium morphogenesis (GO:0072088)2.58929461
123* neuron development (GO:0048666)2.58243091
124positive regulation of triglyceride biosynthetic process (GO:0010867)2.58084714
125maturation of SSU-rRNA (GO:0030490)2.57977229
126protein targeting to ER (GO:0045047)2.57432247
127proteasome assembly (GO:0043248)2.57284326
128regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.57250899
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57239778
130platelet dense granule organization (GO:0060155)2.56439103
131lymphoid progenitor cell differentiation (GO:0002320)2.55803594
132negative regulation of cardiac muscle tissue development (GO:0055026)2.55333837
133postsynaptic membrane organization (GO:0001941)2.53992346
134detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.53534725
135regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.52878366
136mesonephros development (GO:0001823)2.52408415
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51733054
138flavonoid metabolic process (GO:0009812)2.51317664
139translational elongation (GO:0006414)2.49385256
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49248140
141cellular anion homeostasis (GO:0030002)2.48028115
142protein localization to endoplasmic reticulum (GO:0070972)2.47530267
143presynaptic membrane organization (GO:0097090)2.47499807
144motile cilium assembly (GO:0044458)2.47353506
145peptidyl-threonine dephosphorylation (GO:0035970)2.47324955
146righting reflex (GO:0060013)2.46146341
147response to UV-C (GO:0010225)2.46096550
148neuronal action potential (GO:0019228)2.45615007
149activated T cell proliferation (GO:0050798)2.45035563
150negative regulation of axon guidance (GO:1902668)2.45010203
151presynaptic membrane assembly (GO:0097105)2.44893047
152DNA ligation (GO:0006266)2.44563751
153respiratory chain complex IV assembly (GO:0008535)2.44510861
154negative regulation of astrocyte differentiation (GO:0048712)2.44223573
155facial nerve structural organization (GO:0021612)2.44221318
156viral mRNA export from host cell nucleus (GO:0046784)2.43964053
157DNA replication initiation (GO:0006270)2.43957943
158positive regulation of potassium ion transmembrane transport (GO:1901381)2.42860051
159pyrimidine nucleotide catabolic process (GO:0006244)2.42714539
160pseudouridine synthesis (GO:0001522)2.42342464
161telomere maintenance via telomere lengthening (GO:0010833)2.40755218
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40135457
163establishment of protein localization to endoplasmic reticulum (GO:0072599)2.39674807
164piRNA metabolic process (GO:0034587)2.39475061
165protein localization to synapse (GO:0035418)2.39221781
166nucleotide-excision repair, DNA gap filling (GO:0006297)2.39045898
167positive regulation of neurotransmitter transport (GO:0051590)2.38123772
168nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.36139611
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34386928
170negative regulation of interleukin-1 beta production (GO:0032691)2.33821436
171epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.33739047
172negative regulation of Rho protein signal transduction (GO:0035024)2.33582541
173ATP synthesis coupled proton transport (GO:0015986)2.32763434
174energy coupled proton transport, down electrochemical gradient (GO:0015985)2.32763434
175histone H2A acetylation (GO:0043968)2.32527711
176positive regulation of cGMP biosynthetic process (GO:0030828)2.30866451
177nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.27639257
178viral life cycle (GO:0019058)2.25823041
179termination of RNA polymerase III transcription (GO:0006386)2.24813289
180transcription elongation from RNA polymerase III promoter (GO:0006385)2.24813289
181deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.24203268
182GDP-mannose metabolic process (GO:0019673)2.22566819
183intra-S DNA damage checkpoint (GO:0031573)2.21710683
184histone H3-K4 trimethylation (GO:0080182)2.19671450
185cellular protein complex disassembly (GO:0043624)2.19278534
186CENP-A containing nucleosome assembly (GO:0034080)2.18361258
187response to pheromone (GO:0019236)2.17927444
188regulation of rhodopsin mediated signaling pathway (GO:0022400)12.0706877
189rhodopsin mediated signaling pathway (GO:0016056)11.8274938
190retinal cone cell development (GO:0046549)10.0878651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42072503
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38812951
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06394666
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.04079984
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00446462
6ZNF274_21170338_ChIP-Seq_K562_Hela2.98169443
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91837521
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75703679
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.74601427
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70119890
11SCL_19346495_ChIP-Seq_HPC-7_Human2.63873675
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.61741954
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60851690
14GBX2_23144817_ChIP-Seq_PC3_Human2.58383874
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57895979
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.48714774
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47303978
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39170638
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.35721275
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32831834
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32522997
22CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.21482530
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17417885
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16616313
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16403607
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.13887603
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12657210
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06964320
29FUS_26573619_Chip-Seq_HEK293_Human2.06360797
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.05446997
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.03829110
32EWS_26573619_Chip-Seq_HEK293_Human2.02277146
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98040678
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97627768
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94136532
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93586599
37VDR_23849224_ChIP-Seq_CD4+_Human1.92121047
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90123169
39FOXP3_21729870_ChIP-Seq_TREG_Human1.88210497
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87675489
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87072038
42P300_19829295_ChIP-Seq_ESCs_Human1.83374090
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82602124
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77517688
45ER_23166858_ChIP-Seq_MCF-7_Human1.76391089
46TAF15_26573619_Chip-Seq_HEK293_Human1.74571681
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74521963
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74421259
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71569158
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68418174
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67820125
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.67498212
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67054388
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67034365
55BCAT_22108803_ChIP-Seq_LS180_Human1.65303856
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.64290835
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62055311
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61739977
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.61320102
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60428953
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59654095
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59570009
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.58120499
64* CIITA_25753668_ChIP-Seq_RAJI_Human1.54635102
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54428607
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54045315
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53582785
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52856981
69TTF2_22483619_ChIP-Seq_HELA_Human1.52258582
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50158528
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.49333221
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48539976
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48539976
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.47561482
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46462571
76* CBP_20019798_ChIP-Seq_JUKART_Human1.44889553
77* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44889553
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44843070
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42651776
80SPI1_23547873_ChIP-Seq_NB4_Human1.41942115
81* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41676046
82XRN2_22483619_ChIP-Seq_HELA_Human1.38983514
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36149556
84MYC_18940864_ChIP-ChIP_HL60_Human1.34817064
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33196019
86IGF1R_20145208_ChIP-Seq_DFB_Human1.33036186
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.33009492
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.32477803
89REST_21632747_ChIP-Seq_MESCs_Mouse1.32184735
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29610143
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28451386
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26690003
93ELK1_19687146_ChIP-ChIP_HELA_Human1.25659723
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24763121
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23960818
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23724626
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23684114
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22866148
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22356896
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22103864
101GABP_19822575_ChIP-Seq_HepG2_Human1.21829013
102RNF2_27304074_Chip-Seq_NSC_Mouse1.21815489
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21636199
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.20883493
105NCOR_22424771_ChIP-Seq_293T_Human1.20544660
106TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20293495
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.19987011
108IRF1_19129219_ChIP-ChIP_H3396_Human1.19093319
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.18143762
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18004243
111DCP1A_22483619_ChIP-Seq_HELA_Human1.16036144
112AR_25329375_ChIP-Seq_VCAP_Human1.15889117
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15462843
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15418885
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14704097
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13649745
117STAT3_23295773_ChIP-Seq_U87_Human1.13604902
118ERG_20517297_ChIP-Seq_VCAP_Human1.13331206
119TCF4_23295773_ChIP-Seq_U87_Human1.12841637
120SMAD4_21799915_ChIP-Seq_A2780_Human1.12066257
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.10164397
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10154823
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09689836
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09550747
125YY1_22570637_ChIP-Seq_MALME-3M_Human1.09306313
126TCF4_22108803_ChIP-Seq_LS180_Human1.09299130
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08705697
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07566978
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07254878
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07049183
131TP53_22573176_ChIP-Seq_HFKS_Human1.05282401
132ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05272273
133FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04590058
134FOXA1_25329375_ChIP-Seq_VCAP_Human1.04590058
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04470087
136SOX2_19829295_ChIP-Seq_ESCs_Human1.04115138
137NANOG_19829295_ChIP-Seq_ESCs_Human1.04115138
138PIAS1_25552417_ChIP-Seq_VCAP_Human1.04100651
139P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03666259
140E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03017709
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02625197
142FLI1_21867929_ChIP-Seq_TH2_Mouse1.01447711
143RUNX2_22187159_ChIP-Seq_PCA_Human1.01358458
144SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00939726
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00614535
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00155161
147EZH2_27294783_Chip-Seq_ESCs_Mouse0.98495619
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.98101703
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98083470
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.97594013
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96726789
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.95535573
153RNF2_27304074_Chip-Seq_ESCs_Mouse0.94809328
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94729373
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.93501468
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93493329
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93263642
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.93226260
159VDR_21846776_ChIP-Seq_THP-1_Human0.92848305
160NANOG_20526341_ChIP-Seq_ESCs_Human0.91506243
161MYB_26560356_Chip-Seq_TH1_Human0.89455114
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85796291
163SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85594205
164NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85432668
165LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85173731
166GATA3_21867929_ChIP-Seq_CD8_Mouse0.85029585
167SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84914820
168ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84529716
169VDR_22108803_ChIP-Seq_LS180_Human0.84459040
170MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83945715
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83835322
172POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82828678
173* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82811077
174RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82784982
175EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81468278
176EZH2_22144423_ChIP-Seq_EOC_Human0.80985607
177GATA1_19941827_ChIP-Seq_MEL_Mouse0.80067904
178MYC_22102868_ChIP-Seq_BL_Human0.80061708
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78503980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.57345780
2* MP0005551_abnormal_eye_electrophysiolog7.74387475
3MP0006072_abnormal_retinal_apoptosis5.94821276
4MP0005253_abnormal_eye_physiology5.63898417
5MP0006292_abnormal_olfactory_placode3.78005687
6* MP0005195_abnormal_posterior_eye3.28756667
7MP0002138_abnormal_hepatobiliary_system3.23083745
8MP0002638_abnormal_pupillary_reflex3.22290942
9MP0001324_abnormal_eye_pigmentation3.22080294
10MP0005391_vision/eye_phenotype2.81532542
11MP0003195_calcinosis2.80282581
12MP0001986_abnormal_taste_sensitivity2.52826745
13MP0005646_abnormal_pituitary_gland2.42192815
14MP0003950_abnormal_plasma_membrane2.39279397
15MP0002277_abnormal_respiratory_mucosa2.24888932
16* MP0002229_neurodegeneration2.21624223
17MP0001485_abnormal_pinna_reflex2.12408064
18MP0002653_abnormal_ependyma_morphology2.08405009
19MP0004134_abnormal_chest_morphology2.01293288
20MP0005389_reproductive_system_phenotype1.93020431
21MP0005423_abnormal_somatic_nervous1.91402456
22MP0005084_abnormal_gallbladder_morpholo1.84989227
23MP0001968_abnormal_touch/_nociception1.81947640
24MP0001764_abnormal_homeostasis1.77947844
25* MP0002752_abnormal_somatic_nervous1.77321550
26MP0008872_abnormal_physiological_respon1.75439625
27MP0001188_hyperpigmentation1.69681495
28MP0009379_abnormal_foot_pigmentation1.68865099
29MP0008058_abnormal_DNA_repair1.67715369
30MP0002735_abnormal_chemical_nociception1.58439544
31MP0002928_abnormal_bile_duct1.57473701
32MP0002837_dystrophic_cardiac_calcinosis1.56397844
33MP0008007_abnormal_cellular_replicative1.55419875
34MP0008789_abnormal_olfactory_epithelium1.55270437
35MP0002090_abnormal_vision1.53839964
36MP0003787_abnormal_imprinting1.53579695
37MP0005083_abnormal_biliary_tract1.48494806
38MP0005409_darkened_coat_color1.45927609
39MP0009745_abnormal_behavioral_response1.45428633
40MP0002736_abnormal_nociception_after1.42398719
41MP0001486_abnormal_startle_reflex1.41993068
42MP0005499_abnormal_olfactory_system1.39304331
43MP0005394_taste/olfaction_phenotype1.39304331
44MP0004145_abnormal_muscle_electrophysio1.39144082
45MP0002733_abnormal_thermal_nociception1.38574095
46MP0001502_abnormal_circadian_rhythm1.38112320
47MP0005377_hearing/vestibular/ear_phenot1.37742725
48MP0003878_abnormal_ear_physiology1.37742725
49MP0005174_abnormal_tail_pigmentation1.35724432
50MP0000465_gastrointestinal_hemorrhage1.32111105
51MP0000569_abnormal_digit_pigmentation1.29480695
52MP0004133_heterotaxia1.27250794
53MP0003938_abnormal_ear_development1.26439361
54MP0001970_abnormal_pain_threshold1.25274884
55MP0004130_abnormal_muscle_cell1.22998159
56MP0002734_abnormal_mechanical_nocicepti1.22843696
57MP0001919_abnormal_reproductive_system1.21444630
58MP0004742_abnormal_vestibular_system1.19388850
59MP0002876_abnormal_thyroid_physiology1.15668572
60MP0009250_abnormal_appendicular_skeleto1.15289129
61MP0009046_muscle_twitch1.13018396
62MP0005075_abnormal_melanosome_morpholog1.12196076
63MP0000613_abnormal_salivary_gland1.11613367
64MP0000678_abnormal_parathyroid_gland1.09984447
65MP0003638_abnormal_response/metabolism_1.09957224
66MP0002396_abnormal_hematopoietic_system1.08066266
67MP0005410_abnormal_fertilization1.06910688
68MP0002102_abnormal_ear_morphology1.05202884
69MP0002163_abnormal_gland_morphology1.04982832
70MP0002064_seizures1.04069427
71MP0010094_abnormal_chromosome_stability1.04022278
72MP0001440_abnormal_grooming_behavior1.01502244
73* MP0002882_abnormal_neuron_morphology1.00378610
74MP0008057_abnormal_DNA_replication0.99050840
75MP0003693_abnormal_embryo_hatching0.97602765
76MP0003136_yellow_coat_color0.97364456
77MP0001835_abnormal_antigen_presentation0.96450219
78MP0009764_decreased_sensitivity_to0.95968233
79MP0003937_abnormal_limbs/digits/tail_de0.95821707
80MP0006276_abnormal_autonomic_nervous0.94907063
81MP0009333_abnormal_splenocyte_physiolog0.93309801
82MP0001984_abnormal_olfaction0.92192237
83MP0000015_abnormal_ear_pigmentation0.91937449
84MP0003252_abnormal_bile_duct0.91068506
85MP0003635_abnormal_synaptic_transmissio0.87523830
86MP0003698_abnormal_male_reproductive0.86909733
87MP0004885_abnormal_endolymph0.85584701
88MP0008877_abnormal_DNA_methylation0.84310185
89MP0000631_abnormal_neuroendocrine_gland0.83872160
90MP0003567_abnormal_fetal_cardiomyocyte0.83828490
91MP0002095_abnormal_skin_pigmentation0.81628447
92MP0000490_abnormal_crypts_of0.81236840
93MP0003786_premature_aging0.81168001
94MP0003942_abnormal_urinary_system0.81114672
95MP0001905_abnormal_dopamine_level0.80275278
96MP0005197_abnormal_uvea_morphology0.80190719
97MP0000230_abnormal_systemic_arterial0.80035041
98MP0003119_abnormal_digestive_system0.79494837
99MP0005671_abnormal_response_to0.79217913
100MP0003077_abnormal_cell_cycle0.79107787
101MP0002572_abnormal_emotion/affect_behav0.78632016
102MP0002938_white_spotting0.78409332
103MP0003763_abnormal_thymus_physiology0.78149890
104MP0001929_abnormal_gametogenesis0.77536296
105MP0002063_abnormal_learning/memory/cond0.77381850
106MP0002009_preneoplasia0.76033995
107MP0001800_abnormal_humoral_immune0.76010033
108MP0009765_abnormal_xenobiotic_induced0.74709664
109MP0002067_abnormal_sensory_capabilities0.74034799
110MP0004808_abnormal_hematopoietic_stem0.73981347
111MP0003880_abnormal_central_pattern0.72343990
112MP0008995_early_reproductive_senescence0.71142531
113MP0002210_abnormal_sex_determination0.70615425
114MP0001119_abnormal_female_reproductive0.70433959
115MP0003724_increased_susceptibility_to0.70194873
116MP0002282_abnormal_trachea_morphology0.69721632
117MP0004782_abnormal_surfactant_physiolog0.69603608
118MP0009785_altered_susceptibility_to0.69292113
119MP0003111_abnormal_nucleus_morphology0.68604912
120MP0002557_abnormal_social/conspecific_i0.68216512
121MP0001545_abnormal_hematopoietic_system0.67547795
122MP0005397_hematopoietic_system_phenotyp0.67547795
123MP0001542_abnormal_bone_strength0.66293300
124MP0001286_abnormal_eye_development0.65177502
125MP0002148_abnormal_hypersensitivity_rea0.65160405
126MP0001963_abnormal_hearing_physiology0.65004512
127MP0000372_irregular_coat_pigmentation0.63309967
128MP0002398_abnormal_bone_marrow0.63137249
129MP0004142_abnormal_muscle_tone0.62351405
130MP0002160_abnormal_reproductive_system0.60484074
131MP0003646_muscle_fatigue0.59117482
132MP0002751_abnormal_autonomic_nervous0.56874345
133MP0002166_altered_tumor_susceptibility0.56066645
134MP0003943_abnormal_hepatobiliary_system0.55870621
135MP0004147_increased_porphyrin_level0.54320245
136MP0000681_abnormal_thyroid_gland0.53752172
137MP0003879_abnormal_hair_cell0.53186841
138MP0004019_abnormal_vitamin_homeostasis0.52874723
139MP0001853_heart_inflammation0.52707038
140MP0002132_abnormal_respiratory_system0.52573853
141MP0004381_abnormal_hair_follicle0.52154904
142MP0005025_abnormal_response_to0.51740155
143MP0002127_abnormal_cardiovascular_syste0.51458109
144MP0001145_abnormal_male_reproductive0.51144530
145MP0000689_abnormal_spleen_morphology0.51022115
146MP0002272_abnormal_nervous_system0.50962063
147MP0000049_abnormal_middle_ear0.50761073
148MP0000026_abnormal_inner_ear0.50591344
149MP0003315_abnormal_perineum_morphology0.49137728
150MP0008260_abnormal_autophagy0.49048674
151MP0002420_abnormal_adaptive_immunity0.48501081
152MP0000653_abnormal_sex_gland0.48145668
153MP0002722_abnormal_immune_system0.47988913
154MP0001819_abnormal_immune_cell0.47791390
155MP0000716_abnormal_immune_system0.47400929
156MP0001293_anophthalmia0.47053800
157MP0000313_abnormal_cell_death0.46952406
158MP0002723_abnormal_immune_serum0.46534397
159MP0001346_abnormal_lacrimal_gland0.45344143
160MP0002429_abnormal_blood_cell0.45343244

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal rod and cone electroretinograms (HP:0008323)9.82070435
2Bony spicule pigmentary retinopathy (HP:0007737)9.41779783
3Central scotoma (HP:0000603)7.86720782
4* Pendular nystagmus (HP:0012043)7.86599943
5Chorioretinal atrophy (HP:0000533)7.72234456
6Pigmentary retinal degeneration (HP:0001146)7.06325814
7* Abolished electroretinogram (ERG) (HP:0000550)6.77281876
8Abnormality of macular pigmentation (HP:0008002)6.70602564
9Dyschromatopsia (HP:0007641)6.66473907
10Scotoma (HP:0000575)6.49974686
11* Attenuation of retinal blood vessels (HP:0007843)6.13392377
12* Decreased central vision (HP:0007663)5.85172329
13* Severe visual impairment (HP:0001141)5.17734446
14Cone-rod dystrophy (HP:0000548)4.90235695
15Constricted visual fields (HP:0001133)4.89148509
16Posterior subcapsular cataract (HP:0007787)4.87481850
17* Photophobia (HP:0000613)4.86071094
18Type II diabetes mellitus (HP:0005978)4.71582498
19* Macular degeneration (HP:0000608)4.43352184
20* Keratoconus (HP:0000563)4.28768488
21* Increased corneal curvature (HP:0100692)4.28768488
22Vitreoretinal degeneration (HP:0000655)4.09905914
23Retinitis pigmentosa (HP:0000510)3.77701048
24Genetic anticipation (HP:0003743)3.64996752
25Progressive cerebellar ataxia (HP:0002073)3.12512217
26Asplenia (HP:0001746)2.99311227
273-Methylglutaconic aciduria (HP:0003535)2.95551877
28Methylmalonic acidemia (HP:0002912)2.95409563
29Hypoplastic pelvis (HP:0008839)2.93943820
30Progressive visual loss (HP:0000529)2.90971447
31Aplasia/Hypoplasia of the spleen (HP:0010451)2.90694897
32Methylmalonic aciduria (HP:0012120)2.87394586
33Congenital sensorineural hearing impairment (HP:0008527)2.86900246
34Agitation (HP:0000713)2.80828086
35Abnormality of homocysteine metabolism (HP:0010919)2.78553643
36Homocystinuria (HP:0002156)2.78553643
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.73917977
38Optic disc pallor (HP:0000543)2.72956332
39Porencephaly (HP:0002132)2.72326294
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.70257418
41Choroideremia (HP:0001139)2.64393121
42Congenital, generalized hypertrichosis (HP:0004540)2.60494536
43Abnormality of DNA repair (HP:0003254)2.58543285
44Confusion (HP:0001289)2.57798454
45Type I transferrin isoform profile (HP:0003642)2.56092510
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49327432
47Subcapsular cataract (HP:0000523)2.45854702
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.30720236
49Conjunctival hamartoma (HP:0100780)2.25198899
50Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24327405
51Small hand (HP:0200055)2.24268571
52Congenital primary aphakia (HP:0007707)2.22902446
53Medial flaring of the eyebrow (HP:0010747)2.21893382
54Wide nasal bridge (HP:0000431)2.21848766
55Absent thumb (HP:0009777)2.18244128
56Reduced antithrombin III activity (HP:0001976)2.18196396
57Gait imbalance (HP:0002141)2.16636730
58Abnormal number of erythroid precursors (HP:0012131)2.16332302
59Abnormality of the phalanges of the 5th finger (HP:0004213)2.13959974
60Chronic hepatic failure (HP:0100626)2.11743865
61Nephrogenic diabetes insipidus (HP:0009806)2.11330183
62Abnormality of the proximal phalanges of the hand (HP:0009834)2.10520640
63Mitochondrial inheritance (HP:0001427)2.08660705
64Gaze-evoked nystagmus (HP:0000640)2.08289892
65Abnormality of chromosome stability (HP:0003220)2.08236052
66Abnormality of the ileum (HP:0001549)2.08128030
67Meckel diverticulum (HP:0002245)2.07799673
68Hemiplegia (HP:0002301)2.07174855
69Absent septum pellucidum (HP:0001331)2.06901045
70Acute necrotizing encephalopathy (HP:0006965)2.06789521
71Abnormality of cells of the erythroid lineage (HP:0012130)2.06186744
72Stomach cancer (HP:0012126)2.05344589
73Congenital stationary night blindness (HP:0007642)11.3350493
74* Absent rod-and cone-mediated responses on ERG (HP:0007688)10.8534644
75Hypoplasia of the fovea (HP:0007750)1.94100832
76Aplasia/Hypoplasia of the fovea (HP:0008060)1.94100832
77Anomalous pulmonary venous return (HP:0010772)1.92389314
78Goiter (HP:0000853)1.90390244
79Abnormality of the renal collecting system (HP:0004742)1.89466958
80Abnormality of the vitamin B12 metabolism (HP:0004341)1.88900024
81Hypoplasia of the uterus (HP:0000013)1.88540290
82Oral leukoplakia (HP:0002745)1.84986598
83Progressive macrocephaly (HP:0004481)1.84259080
84Type II lissencephaly (HP:0007260)1.83768976
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80935964
86Abnormality of the nasal septum (HP:0000419)1.80772749
87Abnormality of the renal cortex (HP:0011035)1.80620203
88Aplasia/hypoplasia of the uterus (HP:0008684)1.80297111
89* Furrowed tongue (HP:0000221)1.80002329
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77641963
91Short 4th metacarpal (HP:0010044)1.77641963
92Recurrent sinusitis (HP:0011108)1.77531150
93Horizontal nystagmus (HP:0000666)1.77188865
94Abnormality of the middle phalanges of the toes (HP:0010183)1.77054409
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.76781593
96Colon cancer (HP:0003003)1.76548926
97Stomatitis (HP:0010280)1.76231215
98Abnormality of vitamin B metabolism (HP:0004340)1.75744617
99Abnormality of the fovea (HP:0000493)1.75264411
100Elevated erythrocyte sedimentation rate (HP:0003565)1.75258369
101Short femoral neck (HP:0100864)1.73220500
102Hypogonadotrophic hypogonadism (HP:0000044)1.71125426
103Gonadotropin excess (HP:0000837)1.70811984
104Ectopic kidney (HP:0000086)1.70370447
105Aplastic anemia (HP:0001915)1.68512452
106Short hallux (HP:0010109)1.67964009
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67234791
108Abnormal protein N-linked glycosylation (HP:0012347)1.67234791
109Abnormal protein glycosylation (HP:0012346)1.67234791
110Abnormal glycosylation (HP:0012345)1.67234791
111Hyperventilation (HP:0002883)1.67138374
112Poor coordination (HP:0002370)1.66882267
113Abnormality of the pulmonary veins (HP:0011718)1.66688433
114Hypothermia (HP:0002045)1.65322969
115Cleft eyelid (HP:0000625)1.64900047
116Abnormality of the septum pellucidum (HP:0007375)1.64658642
117Decreased circulating renin level (HP:0003351)1.64448668
118Thyroid-stimulating hormone excess (HP:0002925)1.64346888
119* Anencephaly (HP:0002323)1.63920065
120Increased CSF lactate (HP:0002490)1.63159879
121Abnormality of the preputium (HP:0100587)1.63063635
122Aplasia/Hypoplasia of the hallux (HP:0008362)1.62751801
123Short tibia (HP:0005736)1.62290778
124Clubbing of toes (HP:0100760)1.62243478
125* True hermaphroditism (HP:0010459)1.61984783
126Pallor (HP:0000980)1.59825746
127Reticulocytopenia (HP:0001896)1.59376673
128* Optic atrophy (HP:0000648)1.57483302
129Absent/shortened dynein arms (HP:0200106)1.52729900
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.52729900
131* Pancreatic fibrosis (HP:0100732)1.51505239
132Chorioretinal coloboma (HP:0000567)1.50254551
133Aplasia/Hypoplasia of the lens (HP:0008063)1.49906437
134Type 2 muscle fiber atrophy (HP:0003554)1.49586722
135Interstitial pulmonary disease (HP:0006530)1.47320236
136Abnormality of midbrain morphology (HP:0002418)1.46154772
137Molar tooth sign on MRI (HP:0002419)1.46154772
138Polar cataract (HP:0010696)1.45344566
139Nonprogressive disorder (HP:0003680)1.38606678
140Vaginal atresia (HP:0000148)1.34984026
141Nephronophthisis (HP:0000090)1.32889787
142Aplasia/Hypoplasia of the macula (HP:0008059)1.32035947
143Genital tract atresia (HP:0001827)1.31211684
144Albinism (HP:0001022)1.29080727
145Retinal atrophy (HP:0001105)1.29063321
146* Pancreatic cysts (HP:0001737)1.27957053
147Muscle fiber atrophy (HP:0100295)1.27860480
148Optic nerve hypoplasia (HP:0000609)1.27417150
149Abnormality of the heme biosynthetic pathway (HP:0010472)1.26988892
150Abnormality of dental color (HP:0011073)1.26445444
151Optic nerve coloboma (HP:0000588)1.26197387
152Septo-optic dysplasia (HP:0100842)1.26193810
153Astigmatism (HP:0000483)1.21593395
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.20944982
155Lymphopenia (HP:0001888)1.20041507
156Abnormal respiratory epithelium morphology (HP:0012253)1.19820836
157Abnormal respiratory motile cilium morphology (HP:0005938)1.19820836
158Abnormality of the columella (HP:0009929)1.17962813
159Acute lymphatic leukemia (HP:0006721)1.13965315
160Abnormality of cells of the lymphoid lineage (HP:0012140)1.13313523
161* Aplasia/Hypoplasia of the tongue (HP:0010295)1.13164124
162Severe Myopia (HP:0011003)1.12242009
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.11364634
164Aplasia/Hypoplasia affecting the retina (HP:0008061)1.09698793
165* Sclerocornea (HP:0000647)1.09433805
166Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.09363907
167Birth length less than 3rd percentile (HP:0003561)1.09234879
168Increased hepatocellular lipid droplets (HP:0006565)1.08438653
169Abnormality of the fingertips (HP:0001211)1.08170768
170Abnormality of the renal medulla (HP:0100957)1.06507114
171Median cleft lip (HP:0000161)1.03979868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.19843740
2TNIK5.15241969
3FRK3.68341879
4MKNK23.56755598
5STK163.10245555
6MUSK2.99927489
7MKNK12.85121175
8EIF2AK32.33730393
9WEE12.28111934
10CASK2.12953103
11SRPK12.10899224
12WNK32.05638861
13IRAK21.95153409
14NLK1.89659292
15NME21.89328013
16PBK1.79511304
17TEC1.75173205
18TAF11.73483814
19PINK11.68480257
20KIT1.66084453
21MAP3K101.56573719
22MAP4K21.48728650
23VRK11.47101555
24DYRK21.45051951
25TLK11.44536390
26VRK21.43985279
27IRAK41.37164422
28YES11.33976817
29INSRR1.32009718
30DYRK31.29811123
31MAP2K71.28913037
32EIF2AK21.27641129
33NTRK21.27403012
34BUB11.25840461
35MAP3K41.22588777
36FES1.22030926
37PIM21.17932530
38BCKDK1.17252657
39MAP3K91.15733825
40DAPK21.11922742
41CDK191.10911166
42GRK61.10691093
43ACVR1B1.10635767
44HIPK21.10397936
45GRK71.08369861
46NEK21.08260758
47CAMK11.08112841
48PRPF4B1.02965141
49CDC71.02938088
50OXSR11.02100439
51WNK41.01902557
52EIF2AK10.99828076
53BTK0.99349354
54MARK10.94203521
55CDK30.91094900
56RPS6KA40.86442418
57BRD40.85359534
58CCNB10.84856604
59CDK70.84644539
60MST40.83449796
61PRKCG0.83191568
62ADRBK20.82606123
63BRSK20.82354593
64PAK30.81679477
65IRAK30.81513157
66ATR0.80498695
67CSK0.80259671
68IKBKE0.78265004
69NTRK30.77923448
70TXK0.75750970
71CLK10.74189229
72PRKCQ0.72912466
73KDR0.72261433
74IRAK10.71833704
75PTK2B0.69594275
76DYRK1A0.68851957
77STK110.67808813
78ITK0.67045454
79IKBKB0.66676294
80FLT30.66160038
81PIM10.65678700
82PLK40.65509520
83CAMKK20.64918239
84PLK10.63167110
85SCYL20.63004632
86CSNK1G20.61640360
87SGK4940.61538127
88TAOK30.60975229
89DYRK1B0.60673223
90SGK20.58326037
91ADRBK10.58052987
92PRKCH0.57680447
93TIE10.57586993
94HCK0.55936999
95CHEK20.55866277
96MAPK130.55334475
97PRKCE0.54888684
98MAP2K40.54885377
99SYK0.53518877
100PRKACA0.53516878
101CSNK1G10.52663875
102NME10.52124518
103PRKD20.51352777
104PLK30.50743965
105AKT30.50230794
106MAP3K120.50020606
107PRKCZ0.49517580
108MAPK40.49014891
109RPS6KA60.48923702
110CSNK2A10.48768975
111MAP3K140.48240135
112STK390.48073548
113MAP3K110.47575084
114ERBB20.47441015
115LYN0.47316217
116PKN10.47279549
117PNCK0.46868163
118CSF1R0.46035507
119MAP4K10.45896937
120LCK0.45692591
121GRK50.45031967
122ZAK0.44803876
123MAPK120.44517792
124ATM0.44436883
125MARK30.44273982
126CAMK2A0.43821990
127SIK20.42814227
128CSNK1G30.42562258
129TNK20.42502953
130NEK60.42472088
131ABL10.42404125
132CSNK1A10.41364909
133MYLK0.41142312
134ABL20.40481198
135RPS6KA50.38789044
136MATK0.38719546
137CSNK2A20.38452441
138NUAK10.38446477
139IGF1R0.38318649
140STK380.38203766
141PLK20.36034936
142TGFBR10.35910110
143CHUK0.34613181
144PIK3CA0.34384705
145CDK10.33444252
146MAPK70.33338263
147CSNK1A1L0.33270215
148AURKA0.32175658
149CDK80.31836458
150BMPR1B0.31722184
151BLK0.31237250
152TBK10.30051792
153SGK2230.29623764

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.92241611
2Ribosome_Homo sapiens_hsa030102.64596539
3Mismatch repair_Homo sapiens_hsa034302.21569962
4Phototransduction_Homo sapiens_hsa0474412.6512563
5Homologous recombination_Homo sapiens_hsa034401.94550092
6Base excision repair_Homo sapiens_hsa034101.90713731
7Spliceosome_Homo sapiens_hsa030401.83822471
8RNA polymerase_Homo sapiens_hsa030201.80384382
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80316603
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75229479
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75218695
12Nitrogen metabolism_Homo sapiens_hsa009101.71984281
13Alzheimers disease_Homo sapiens_hsa050101.62815248
14Taste transduction_Homo sapiens_hsa047421.62491118
15Fanconi anemia pathway_Homo sapiens_hsa034601.60723725
16Pyrimidine metabolism_Homo sapiens_hsa002401.57958723
17Purine metabolism_Homo sapiens_hsa002301.54457898
18Nucleotide excision repair_Homo sapiens_hsa034201.48185907
19Hedgehog signaling pathway_Homo sapiens_hsa043401.43279925
20Basal transcription factors_Homo sapiens_hsa030221.39184618
21Chemical carcinogenesis_Homo sapiens_hsa052041.34856325
22RNA degradation_Homo sapiens_hsa030181.34639230
23Vitamin digestion and absorption_Homo sapiens_hsa049771.33916478
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33137777
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28006477
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22465691
27Non-homologous end-joining_Homo sapiens_hsa034501.21219876
28Selenocompound metabolism_Homo sapiens_hsa004501.18697827
29Melanoma_Homo sapiens_hsa052181.18377078
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18044388
31Protein export_Homo sapiens_hsa030601.16782721
32Tryptophan metabolism_Homo sapiens_hsa003801.13670630
33Caffeine metabolism_Homo sapiens_hsa002321.13167986
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.08739453
35N-Glycan biosynthesis_Homo sapiens_hsa005101.07612027
36Proteasome_Homo sapiens_hsa030501.06567585
37Basal cell carcinoma_Homo sapiens_hsa052171.05897750
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01434423
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98526808
40Synaptic vesicle cycle_Homo sapiens_hsa047210.95836441
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93012997
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90907404
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89736093
44Dorso-ventral axis formation_Homo sapiens_hsa043200.88619153
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87456351
46Ether lipid metabolism_Homo sapiens_hsa005650.86334504
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83603784
48Glycerolipid metabolism_Homo sapiens_hsa005610.82351679
49Olfactory transduction_Homo sapiens_hsa047400.82327240
50Primary immunodeficiency_Homo sapiens_hsa053400.82108521
51RNA transport_Homo sapiens_hsa030130.81216383
52Herpes simplex infection_Homo sapiens_hsa051680.79729341
53Cell cycle_Homo sapiens_hsa041100.78959689
54mRNA surveillance pathway_Homo sapiens_hsa030150.75944825
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75333674
56Regulation of autophagy_Homo sapiens_hsa041400.73777490
57Insulin secretion_Homo sapiens_hsa049110.73456627
58Retinol metabolism_Homo sapiens_hsa008300.69171060
59Staphylococcus aureus infection_Homo sapiens_hsa051500.68871248
60Circadian rhythm_Homo sapiens_hsa047100.67797446
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66143473
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64387962
63ABC transporters_Homo sapiens_hsa020100.61017624
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.60277402
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59067217
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56698065
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56219447
68Huntingtons disease_Homo sapiens_hsa050160.54847209
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54647000
70p53 signaling pathway_Homo sapiens_hsa041150.54567906
71Sulfur relay system_Homo sapiens_hsa041220.54147626
72Calcium signaling pathway_Homo sapiens_hsa040200.54062306
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53982031
74GABAergic synapse_Homo sapiens_hsa047270.53602312
75Allograft rejection_Homo sapiens_hsa053300.52967002
76MAPK signaling pathway_Homo sapiens_hsa040100.52942413
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.52159237
78Ovarian steroidogenesis_Homo sapiens_hsa049130.51646848
79Butanoate metabolism_Homo sapiens_hsa006500.51402951
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50695688
81Type I diabetes mellitus_Homo sapiens_hsa049400.50495940
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49782443
83Peroxisome_Homo sapiens_hsa041460.49265383
84cAMP signaling pathway_Homo sapiens_hsa040240.49001063
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47680693
86Thyroid cancer_Homo sapiens_hsa052160.47036017
87Rheumatoid arthritis_Homo sapiens_hsa053230.45971520
88Ras signaling pathway_Homo sapiens_hsa040140.45339715
89T cell receptor signaling pathway_Homo sapiens_hsa046600.44724738
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44672495
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44407498
92Measles_Homo sapiens_hsa051620.44317874
93Hematopoietic cell lineage_Homo sapiens_hsa046400.44104515
94One carbon pool by folate_Homo sapiens_hsa006700.42530529
95Type II diabetes mellitus_Homo sapiens_hsa049300.41655929
96Arachidonic acid metabolism_Homo sapiens_hsa005900.41112206
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38505704
98Morphine addiction_Homo sapiens_hsa050320.38334865
99Serotonergic synapse_Homo sapiens_hsa047260.37977506
100Cholinergic synapse_Homo sapiens_hsa047250.37852142
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37191051
102Alcoholism_Homo sapiens_hsa050340.36388079
103Asthma_Homo sapiens_hsa053100.35032184
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.34673204
105Cardiac muscle contraction_Homo sapiens_hsa042600.34650403
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34297828
107Pentose phosphate pathway_Homo sapiens_hsa000300.34081767
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.33492282
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.32267644
110Epstein-Barr virus infection_Homo sapiens_hsa051690.32175869
111Circadian entrainment_Homo sapiens_hsa047130.31709756
112Oxidative phosphorylation_Homo sapiens_hsa001900.31397548
113Glutamatergic synapse_Homo sapiens_hsa047240.30573979
114Systemic lupus erythematosus_Homo sapiens_hsa053220.27806905
115Other glycan degradation_Homo sapiens_hsa005110.27583107
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27397474
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26342007
118Fructose and mannose metabolism_Homo sapiens_hsa000510.26038387
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.25880200
120Folate biosynthesis_Homo sapiens_hsa007900.25054114
121Acute myeloid leukemia_Homo sapiens_hsa052210.24741447
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23899917
123Sphingolipid metabolism_Homo sapiens_hsa006000.23649281
124Parkinsons disease_Homo sapiens_hsa050120.23290835
125Galactose metabolism_Homo sapiens_hsa000520.22764479
126Antigen processing and presentation_Homo sapiens_hsa046120.22117615
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22079480
128Notch signaling pathway_Homo sapiens_hsa043300.21137328
129Linoleic acid metabolism_Homo sapiens_hsa005910.18930115
130Influenza A_Homo sapiens_hsa051640.17869789
131Autoimmune thyroid disease_Homo sapiens_hsa053200.17659555
132Nicotine addiction_Homo sapiens_hsa050330.15624765
133Metabolic pathways_Homo sapiens_hsa011000.15520489
134Wnt signaling pathway_Homo sapiens_hsa043100.15320831
135Leishmaniasis_Homo sapiens_hsa051400.15108054
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14467441
137Graft-versus-host disease_Homo sapiens_hsa053320.13901144
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13351678
139B cell receptor signaling pathway_Homo sapiens_hsa046620.12278446
140HIF-1 signaling pathway_Homo sapiens_hsa040660.11479796
141HTLV-I infection_Homo sapiens_hsa051660.11280667
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.10837253
143Inositol phosphate metabolism_Homo sapiens_hsa005620.10730798
144Dopaminergic synapse_Homo sapiens_hsa047280.09230027
145Malaria_Homo sapiens_hsa051440.08963756
146Oocyte meiosis_Homo sapiens_hsa041140.08310761

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