RPGR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)6.27002071
2centriole assembly (GO:0098534)5.39536005
3cilium or flagellum-dependent cell motility (GO:0001539)5.27578410
4left/right axis specification (GO:0070986)4.80010937
5cilium movement (GO:0003341)4.74794958
6axonemal dynein complex assembly (GO:0070286)4.53383088
7neutrophil mediated immunity (GO:0002446)4.45484832
8epithelial cilium movement (GO:0003351)4.26734864
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11268305
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04862142
11auditory behavior (GO:0031223)4.03503293
12response to pheromone (GO:0019236)4.03163252
13protein localization to synapse (GO:0035418)3.89734246
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82332257
15startle response (GO:0001964)3.81048748
16positive regulation of tolerance induction (GO:0002645)3.80252715
17protein localization to cilium (GO:0061512)3.79087610
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78379313
19regulation of cilium movement (GO:0003352)3.76885464
20* intraciliary transport (GO:0042073)3.76747774
21establishment of protein localization to Golgi (GO:0072600)3.75958404
22protein targeting to Golgi (GO:0000042)3.75202185
23axoneme assembly (GO:0035082)3.67135204
24neuron cell-cell adhesion (GO:0007158)3.63566380
25response to auditory stimulus (GO:0010996)3.61281554
26innervation (GO:0060384)3.57336825
27mechanosensory behavior (GO:0007638)3.57250526
28regulation of tolerance induction (GO:0002643)3.55592792
29vocalization behavior (GO:0071625)3.53121389
30synaptic transmission, glutamatergic (GO:0035249)3.52410792
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.50212198
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43550387
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42421757
34cellular extravasation (GO:0045123)3.38166329
35neuron-neuron synaptic transmission (GO:0007270)3.33889685
36neuronal stem cell maintenance (GO:0097150)3.30236856
37myeloid leukocyte mediated immunity (GO:0002444)3.27536988
38neuron fate determination (GO:0048664)3.25132346
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.22930830
40regulation of centriole replication (GO:0046599)3.22563739
41synaptic vesicle exocytosis (GO:0016079)3.21482497
42regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.19258475
43ventricular system development (GO:0021591)3.19233980
44axonal fasciculation (GO:0007413)3.18731682
45regulation of DNA endoreduplication (GO:0032875)3.18425650
46* cilium organization (GO:0044782)3.17337618
47cochlea development (GO:0090102)3.14506086
48glutamate receptor signaling pathway (GO:0007215)3.14153618
49* microtubule-based movement (GO:0007018)3.13976518
50sperm motility (GO:0030317)3.13897313
51* cilium assembly (GO:0042384)3.13839042
52microglial cell activation (GO:0001774)3.13035608
53negative regulation of humoral immune response (GO:0002921)3.11412796
54neuron recognition (GO:0008038)3.10909541
55* cell projection assembly (GO:0030031)3.10652192
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06898104
57negative regulation of organelle assembly (GO:1902116)3.05094589
58motile cilium assembly (GO:0044458)3.04941047
59layer formation in cerebral cortex (GO:0021819)3.03780592
60regulation of glutamate receptor signaling pathway (GO:1900449)3.03083083
61interkinetic nuclear migration (GO:0022027)3.02950351
62regulation of synaptic vesicle exocytosis (GO:2000300)3.01147648
63protein K11-linked deubiquitination (GO:0035871)2.99050239
64positive regulation of synapse maturation (GO:0090129)2.98077309
65smoothened signaling pathway (GO:0007224)2.97265817
66regulation of cardioblast proliferation (GO:0003264)2.95470551
67regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95470551
68postsynaptic membrane organization (GO:0001941)2.94654026
69synaptic vesicle maturation (GO:0016188)2.94501651
70leukocyte migration involved in inflammatory response (GO:0002523)2.93618923
71regulation of interleukin-6 biosynthetic process (GO:0045408)2.92906235
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.89096430
73response to histamine (GO:0034776)2.86447240
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85075362
75positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84514127
76auditory receptor cell differentiation (GO:0042491)2.82857397
77negative regulation of immunoglobulin mediated immune response (GO:0002890)2.82249062
78negative regulation of B cell mediated immunity (GO:0002713)2.82249062
79positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.81970754
80dendritic spine morphogenesis (GO:0060997)2.81949645
81radial glial cell differentiation (GO:0060019)2.80331181
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79419166
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.79419166
84regulation of translation, ncRNA-mediated (GO:0045974)2.79419166
85transmission of nerve impulse (GO:0019226)2.78762168
86righting reflex (GO:0060013)2.77103194
87centrosome localization (GO:0051642)2.77082237
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76837425
89striatum development (GO:0021756)2.76482395
90membrane hyperpolarization (GO:0060081)2.76181759
91eye photoreceptor cell differentiation (GO:0001754)2.75856504
92photoreceptor cell differentiation (GO:0046530)2.75856504
93intra-S DNA damage checkpoint (GO:0031573)2.75170908
94central nervous system projection neuron axonogenesis (GO:0021952)2.74743662
95dendrite development (GO:0016358)2.73250741
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72901249
97presynaptic membrane assembly (GO:0097105)2.72727145
98microtubule bundle formation (GO:0001578)2.72402871
99photoreceptor cell maintenance (GO:0045494)2.71960610
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.70674497
101detection of molecule of bacterial origin (GO:0032490)2.70541075
102regulation of dopamine metabolic process (GO:0042053)2.69623227
103regulation of catecholamine metabolic process (GO:0042069)2.69623227
104glutamate secretion (GO:0014047)2.69250542
105retinal rod cell development (GO:0046548)2.69103672
106synapse assembly (GO:0007416)2.68266752
107microtubule depolymerization (GO:0007019)2.67992807
108CENP-A containing nucleosome assembly (GO:0034080)2.67834905
109regulation of feeding behavior (GO:0060259)2.66869115
110regulation of synaptic vesicle transport (GO:1902803)2.64742901
111monoubiquitinated protein deubiquitination (GO:0035520)2.64053758
112killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.63010138
113disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.63010138
114synaptic vesicle endocytosis (GO:0048488)2.61962113
115regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.61420692
116protein polyglutamylation (GO:0018095)2.60256102
117positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.59897799
118cerebellum development (GO:0021549)2.58608285
119long-term memory (GO:0007616)2.58540472
120protein localization to Golgi apparatus (GO:0034067)2.57349421
121limb bud formation (GO:0060174)2.56424063
122cilium morphogenesis (GO:0060271)2.56286463
123chromatin remodeling at centromere (GO:0031055)2.55536790
124hindbrain development (GO:0030902)2.54951340
125neurotransmitter-gated ion channel clustering (GO:0072578)2.54421384
126GTP biosynthetic process (GO:0006183)2.54363668
127regulation of sister chromatid cohesion (GO:0007063)2.54280407
128pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54243683
129maintenance of gastrointestinal epithelium (GO:0030277)2.54045198
130presynaptic membrane organization (GO:0097090)2.53177410
131regulation of microtubule-based movement (GO:0060632)2.53164869
132regulation of neuronal synaptic plasticity (GO:0048168)2.53011069
133long-term synaptic potentiation (GO:0060291)2.51900758
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51358791
135regulation of vesicle fusion (GO:0031338)2.50969191
136maintenance of protein location in nucleus (GO:0051457)2.49664783
137determination of left/right symmetry (GO:0007368)2.49319515
138histone mRNA catabolic process (GO:0071044)2.48937288
139regulation of interleukin-8 secretion (GO:2000482)2.48635947
140nonmotile primary cilium assembly (GO:0035058)2.48309689
141head development (GO:0060322)2.48072164
142microtubule polymerization or depolymerization (GO:0031109)2.46179313
143retinal ganglion cell axon guidance (GO:0031290)2.45887544
144definitive hemopoiesis (GO:0060216)2.45633473
145behavioral defense response (GO:0002209)2.45483383
146behavioral fear response (GO:0001662)2.45483383
147positive regulation of interleukin-8 secretion (GO:2000484)2.45272126
148cullin deneddylation (GO:0010388)2.44937522
149membrane depolarization during action potential (GO:0086010)2.43949205
150pyrimidine nucleotide catabolic process (GO:0006244)2.43924268
151locomotory exploration behavior (GO:0035641)2.43277755
152positive regulation of membrane potential (GO:0045838)2.42814365
153pancreas development (GO:0031016)2.41989817
154regulation of postsynaptic membrane potential (GO:0060078)2.41947222
155hippocampus development (GO:0021766)2.41666250
156regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41139893
157* cellular component assembly involved in morphogenesis (GO:0010927)2.40568772
158left/right pattern formation (GO:0060972)2.39701157
159neural tube formation (GO:0001841)2.38785305
160synapsis (GO:0007129)2.38555444
161terpenoid biosynthetic process (GO:0016114)2.38460334
162histone exchange (GO:0043486)2.37020111
163lateral ventricle development (GO:0021670)2.36331023
164determination of bilateral symmetry (GO:0009855)2.35055523
165* organelle assembly (GO:0070925)2.34401060
166specification of symmetry (GO:0009799)2.34203172
167acrosome reaction (GO:0007340)2.32626724
168negative regulation of T cell differentiation in thymus (GO:0033085)2.32222177
169regulation of germinal center formation (GO:0002634)2.28168702
170platelet dense granule organization (GO:0060155)2.27835602
171kinetochore assembly (GO:0051382)2.24343940
172resolution of meiotic recombination intermediates (GO:0000712)2.23998615
173response to xenobiotic stimulus (GO:0009410)2.23682211
174mitotic G2 DNA damage checkpoint (GO:0007095)2.22918442
175rRNA catabolic process (GO:0016075)2.22661063
176protein K6-linked ubiquitination (GO:0085020)2.21999872
177regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.21833278
178negative regulation of complement activation (GO:0045916)2.20647926
179fusion of sperm to egg plasma membrane (GO:0007342)2.19955044
180limb development (GO:0060173)2.19853627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41428505
2GBX2_23144817_ChIP-Seq_PC3_Human3.79103394
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85203989
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.73092003
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.65712466
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63583981
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40855106
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40590574
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36440465
10TAF15_26573619_Chip-Seq_HEK293_Human2.28950301
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26275727
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.19275577
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.16742683
14REST_21632747_ChIP-Seq_MESCs_Mouse2.15576849
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15055286
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12539138
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11014446
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09031101
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08650877
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08095662
21FUS_26573619_Chip-Seq_HEK293_Human2.04202005
22RNF2_27304074_Chip-Seq_NSC_Mouse2.02607082
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01283643
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96562280
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95258816
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92461586
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.92259101
28P300_19829295_ChIP-Seq_ESCs_Human1.91788703
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84514466
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79046288
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76000283
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70359404
33IGF1R_20145208_ChIP-Seq_DFB_Human1.69812050
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.67874556
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.67336790
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66400528
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65821175
38ZNF274_21170338_ChIP-Seq_K562_Hela1.65599397
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.65412796
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.65094000
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64404791
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62474699
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62474699
44BCAT_22108803_ChIP-Seq_LS180_Human1.62250432
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62040089
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59144158
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58836948
48CBP_20019798_ChIP-Seq_JUKART_Human1.58678666
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58678666
50ELK1_19687146_ChIP-ChIP_HELA_Human1.57543751
51EWS_26573619_Chip-Seq_HEK293_Human1.57376728
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.56869032
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.54738398
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.53187731
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51785806
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.50842500
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48795335
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.47978085
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45784211
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.42493502
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41901296
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41589430
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40924654
64DROSHA_22980978_ChIP-Seq_HELA_Human1.40665499
65VDR_22108803_ChIP-Seq_LS180_Human1.39618922
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38782851
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38712002
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36503721
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33947595
70TCF4_22108803_ChIP-Seq_LS180_Human1.33614531
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33035361
72SOX9_26525672_Chip-Seq_HEART_Mouse1.31574305
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31208783
74VDR_23849224_ChIP-Seq_CD4+_Human1.30784753
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27904932
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27411890
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27411890
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26614887
79CDX2_22108803_ChIP-Seq_LS180_Human1.25905579
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25638821
81STAT3_23295773_ChIP-Seq_U87_Human1.25569068
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24755726
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23803359
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22610533
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.21705135
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20434341
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20261383
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.20042146
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20023890
90TP53_16413492_ChIP-PET_HCT116_Human1.19411299
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19229611
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19170102
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18803019
94GATA3_26560356_Chip-Seq_TH2_Human1.17913395
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17816108
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17797871
97* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17570524
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17411552
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17259827
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16855950
101ER_23166858_ChIP-Seq_MCF-7_Human1.16543519
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15792284
103* TCF4_23295773_ChIP-Seq_U87_Human1.14604657
104P53_22387025_ChIP-Seq_ESCs_Mouse1.14419428
105SALL4_22934838_ChIP-ChIP_CD34+_Human1.13215164
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.13101607
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12933039
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12899876
109AR_25329375_ChIP-Seq_VCAP_Human1.12629236
110NANOG_19829295_ChIP-Seq_ESCs_Human1.12373484
111SOX2_19829295_ChIP-Seq_ESCs_Human1.12373484
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.12140620
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.11909598
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.11352110
115ETV1_20927104_ChIP-Seq_GIST48_Human1.11059220
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10971210
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10566270
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.10349886
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08691644
120P300_18555785_Chip-Seq_ESCs_Mouse1.08160812
121ESR1_20079471_ChIP-ChIP_T-47D_Human1.07573910
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07151777
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06708673
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06540162
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06476935
126AR_21572438_ChIP-Seq_LNCaP_Human1.05685781
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.05372426
128RUNX2_22187159_ChIP-Seq_PCA_Human1.05371954
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04306615
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03177558
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02065420
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.01745228
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.01435858
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00979816
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00057143
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.99334307
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.98862271
138RUNX_20019798_ChIP-Seq_JUKART_Human0.98766167
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98750598
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.98489767
141TBL1_22424771_ChIP-Seq_293T_Human0.98461363
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.97990507
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97955666
144* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97700901
145VDR_24787735_ChIP-Seq_THP-1_Human0.97693004
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.97651969
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96816368
148AR_19668381_ChIP-Seq_PC3_Human0.96397026
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96154076
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.96144129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.22713125
2MP0006054_spinal_hemorrhage3.60612531
3MP0004859_abnormal_synaptic_plasticity3.52473143
4MP0003880_abnormal_central_pattern3.45787644
5MP0003195_calcinosis3.32550874
6MP0003122_maternal_imprinting2.60036820
7MP0002277_abnormal_respiratory_mucosa2.57175407
8MP0003635_abnormal_synaptic_transmissio2.55381356
9MP0000569_abnormal_digit_pigmentation2.52673797
10MP0006292_abnormal_olfactory_placode2.47840776
11MP0006072_abnormal_retinal_apoptosis2.39758082
12MP0003787_abnormal_imprinting2.37520258
13MP0001968_abnormal_touch/_nociception2.34119392
14MP0002928_abnormal_bile_duct2.28899482
15MP0005646_abnormal_pituitary_gland2.24785303
16MP0002063_abnormal_learning/memory/cond2.23309850
17MP0003121_genomic_imprinting2.22631695
18MP0010368_abnormal_lymphatic_system2.22515611
19MP0002736_abnormal_nociception_after2.20623847
20MP0002132_abnormal_respiratory_system2.17383215
21MP0009745_abnormal_behavioral_response2.17301624
22MP0001879_abnormal_lymphatic_vessel2.13589018
23MP0003828_pulmonary_edema2.11476020
24MP0004270_analgesia2.05571293
25MP0000778_abnormal_nervous_system2.05496050
26MP0002572_abnormal_emotion/affect_behav2.02560898
27MP0000465_gastrointestinal_hemorrhage2.00680461
28MP0000383_abnormal_hair_follicle2.00134787
29MP0005423_abnormal_somatic_nervous1.98790713
30MP0004133_heterotaxia1.98299918
31MP0008004_abnormal_stomach_pH1.94548536
32MP0005551_abnormal_eye_electrophysiolog1.90356427
33MP0000631_abnormal_neuroendocrine_gland1.90004649
34MP0002735_abnormal_chemical_nociception1.88296745
35MP0001984_abnormal_olfaction1.84161303
36MP0002064_seizures1.81347413
37MP0001486_abnormal_startle_reflex1.81040723
38MP0004883_abnormal_blood_vessel1.80695932
39MP0003950_abnormal_plasma_membrane1.80643444
40MP0002653_abnormal_ependyma_morphology1.78629651
41MP0005174_abnormal_tail_pigmentation1.74600171
42MP0003943_abnormal_hepatobiliary_system1.73339632
43MP0001529_abnormal_vocalization1.72963036
44MP0009046_muscle_twitch1.72619480
45MP0002282_abnormal_trachea_morphology1.72335123
46MP0005408_hypopigmentation1.72081674
47MP0002734_abnormal_mechanical_nocicepti1.70204880
48MP0008877_abnormal_DNA_methylation1.68594717
49MP0001293_anophthalmia1.66714614
50MP0002184_abnormal_innervation1.63633431
51MP0002272_abnormal_nervous_system1.62879393
52MP0005075_abnormal_melanosome_morpholog1.59630136
53MP0005167_abnormal_blood-brain_barrier1.59514743
54MP0005394_taste/olfaction_phenotype1.59368512
55MP0005499_abnormal_olfactory_system1.59368512
56MP0001986_abnormal_taste_sensitivity1.59059018
57MP0002557_abnormal_social/conspecific_i1.58407691
58* MP0005253_abnormal_eye_physiology1.57835652
59MP0005164_abnormal_response_to1.57278702
60MP0001188_hyperpigmentation1.56844055
61MP0001324_abnormal_eye_pigmentation1.55570396
62MP0003136_yellow_coat_color1.53808052
63MP0001502_abnormal_circadian_rhythm1.52176424
64MP0002405_respiratory_system_inflammati1.50917833
65MP0002102_abnormal_ear_morphology1.49818659
66MP0000049_abnormal_middle_ear1.49188325
67MP0003283_abnormal_digestive_organ1.49077797
68MP0002822_catalepsy1.48152940
69MP0006276_abnormal_autonomic_nervous1.47883436
70MP0002067_abnormal_sensory_capabilities1.47719652
71MP0005248_abnormal_Harderian_gland1.46181865
72MP0002638_abnormal_pupillary_reflex1.41160625
73MP0002168_other_aberrant_phenotype1.40414619
74MP0008789_abnormal_olfactory_epithelium1.39100248
75MP0003878_abnormal_ear_physiology1.36719350
76MP0005377_hearing/vestibular/ear_phenot1.36719350
77MP0001440_abnormal_grooming_behavior1.35092971
78MP0001485_abnormal_pinna_reflex1.32443266
79MP0005084_abnormal_gallbladder_morpholo1.30093308
80MP0000534_abnormal_ureter_morphology1.29637018
81MP0002882_abnormal_neuron_morphology1.28897122
82MP0001970_abnormal_pain_threshold1.26824559
83MP0002733_abnormal_thermal_nociception1.25493413
84MP0005645_abnormal_hypothalamus_physiol1.24005233
85MP0004811_abnormal_neuron_physiology1.22844629
86MP0003123_paternal_imprinting1.22346994
87MP0004043_abnormal_pH_regulation1.21260844
88MP0009764_decreased_sensitivity_to1.20646701
89MP0001501_abnormal_sleep_pattern1.19931916
90MP0005395_other_phenotype1.19576130
91MP0003890_abnormal_embryonic-extraembry1.16985129
92* MP0002752_abnormal_somatic_nervous1.15711945
93MP0002152_abnormal_brain_morphology1.15058067
94MP0001905_abnormal_dopamine_level1.14947692
95MP0000955_abnormal_spinal_cord1.14673440
96MP0002751_abnormal_autonomic_nervous1.12839476
97MP0010678_abnormal_skin_adnexa1.12257209
98MP0002419_abnormal_innate_immunity1.10833036
99MP0003861_abnormal_nervous_system1.10827781
100MP0004381_abnormal_hair_follicle1.10489776
101MP0002095_abnormal_skin_pigmentation1.09784643
102MP0004924_abnormal_behavior1.09207326
103MP0005386_behavior/neurological_phenoty1.09207326
104MP0003942_abnormal_urinary_system1.08979502
105MP0008057_abnormal_DNA_replication1.08974829
106MP0010386_abnormal_urinary_bladder1.08176354
107MP0005187_abnormal_penis_morphology1.07951450
108MP0003698_abnormal_male_reproductive1.07116019
109MP0008058_abnormal_DNA_repair1.06895748
110MP0003938_abnormal_ear_development1.06525141
111MP0000372_irregular_coat_pigmentation1.05733604
112MP0001963_abnormal_hearing_physiology1.05194210
113MP0005410_abnormal_fertilization1.04804185
114MP0003656_abnormal_erythrocyte_physiolo1.04013120
115MP0000537_abnormal_urethra_morphology1.03748976
116MP0000026_abnormal_inner_ear1.02424635
117MP0000427_abnormal_hair_cycle1.01348596
118MP0003252_abnormal_bile_duct1.01044761
119MP0009765_abnormal_xenobiotic_induced0.97113584
120MP0004885_abnormal_endolymph0.96985852
121MP0005195_abnormal_posterior_eye0.96864604
122MP0002909_abnormal_adrenal_gland0.96232187
123MP0001800_abnormal_humoral_immune0.95483962
124MP0004742_abnormal_vestibular_system0.94054479
125MP0002234_abnormal_pharynx_morphology0.93829416
126MP0002249_abnormal_larynx_morphology0.93656140
127MP0002938_white_spotting0.93457662
128MP0001835_abnormal_antigen_presentation0.92654414
129MP0002066_abnormal_motor_capabilities/c0.91539070
130* MP0005391_vision/eye_phenotype0.91368611
131MP0005310_abnormal_salivary_gland0.90404596
132MP0003718_maternal_effect0.89839079
133MP0008875_abnormal_xenobiotic_pharmacok0.88989769
134MP0003119_abnormal_digestive_system0.88040766
135MP0003755_abnormal_palate_morphology0.86915798
136MP0010030_abnormal_orbit_morphology0.86548349
137MP0008995_early_reproductive_senescence0.85624072
138MP0000015_abnormal_ear_pigmentation0.83416023
139MP0005397_hematopoietic_system_phenotyp0.83182447
140MP0001545_abnormal_hematopoietic_system0.83182447
141MP0001929_abnormal_gametogenesis0.82565327
142MP0001853_heart_inflammation0.82562431
143MP0001286_abnormal_eye_development0.82277171
144MP0002723_abnormal_immune_serum0.82045659
145MP0010307_abnormal_tumor_latency0.82013723
146MP0002233_abnormal_nose_morphology0.80773217
147MP0003937_abnormal_limbs/digits/tail_de0.80753055
148MP0003303_peritoneal_inflammation0.80617725
149MP0003011_delayed_dark_adaptation0.80593190
150MP0002229_neurodegeneration0.79634704
151MP0002160_abnormal_reproductive_system0.79349079
152MP0002177_abnormal_outer_ear0.78783513
153MP0002837_dystrophic_cardiac_calcinosis0.78547353
154MP0004808_abnormal_hematopoietic_stem0.78437929
155MP0002127_abnormal_cardiovascular_syste0.78114272
156MP0000678_abnormal_parathyroid_gland0.77997600
157MP0000653_abnormal_sex_gland0.77736876
158MP0009115_abnormal_fat_cell0.77165973
159MP0000249_abnormal_blood_vessel0.76909272
160MP0009250_abnormal_appendicular_skeleto0.75062438
161MP0002116_abnormal_craniofacial_bone0.74555214
162MP0005376_homeostasis/metabolism_phenot0.73758683
163MP0004215_abnormal_myocardial_fiber0.73689026
164MP0002420_abnormal_adaptive_immunity0.73512079
165MP0009785_altered_susceptibility_to0.73271377
166MP0002452_abnormal_antigen_presenting0.72009879
167MP0005025_abnormal_response_to0.71922013
168MP0001819_abnormal_immune_cell0.70100515
169MP0009697_abnormal_copulation0.69996482
170MP0002210_abnormal_sex_determination0.69024136
171MP0009763_increased_sensitivity_to0.66276401
172MP0002163_abnormal_gland_morphology0.63151385

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)5.20052008
2Abnormal respiratory motile cilium physiology (HP:0012261)4.96307585
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.73463348
4Pancreatic fibrosis (HP:0100732)4.59729921
5True hermaphroditism (HP:0010459)4.57645358
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.45984243
7Absent/shortened dynein arms (HP:0200106)4.45984243
8Abnormal respiratory epithelium morphology (HP:0012253)4.42107540
9Abnormal respiratory motile cilium morphology (HP:0005938)4.42107540
10Gait imbalance (HP:0002141)4.11054401
11Medial flaring of the eyebrow (HP:0010747)3.97758144
12Congenital primary aphakia (HP:0007707)3.95083667
13Nasal polyposis (HP:0100582)3.90148563
14Rhinitis (HP:0012384)3.61493329
15Nephrogenic diabetes insipidus (HP:0009806)3.60778849
16Focal motor seizures (HP:0011153)3.54451373
17Abnormality of the nasal mucosa (HP:0000433)3.33532239
18Pancreatic cysts (HP:0001737)3.26809094
19Genital tract atresia (HP:0001827)3.18883903
20Poor coordination (HP:0002370)3.18157302
21Supernumerary spleens (HP:0009799)3.16269312
22Vaginal atresia (HP:0000148)3.10132325
23Tubulointerstitial nephritis (HP:0001970)3.09380520
24* Bronchitis (HP:0012387)3.08848575
25* Chronic sinusitis (HP:0011109)3.01266770
26Occipital encephalocele (HP:0002085)2.98070313
27Abnormality of midbrain morphology (HP:0002418)2.91657794
28Molar tooth sign on MRI (HP:0002419)2.91657794
29Recurrent sinusitis (HP:0011108)2.87222406
30Infertility (HP:0000789)2.86546520
31Nephronophthisis (HP:0000090)2.83076512
32Chronic hepatic failure (HP:0100626)2.82843612
33Male infertility (HP:0003251)2.79281419
34Epileptic encephalopathy (HP:0200134)2.74564121
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.73354955
36Abnormality of the renal medulla (HP:0100957)2.68697735
37Severe visual impairment (HP:0001141)2.68229043
38Cystic liver disease (HP:0006706)2.65651356
39Recurrent otitis media (HP:0000403)2.56259100
40Postaxial foot polydactyly (HP:0001830)2.53944796
41Focal seizures (HP:0007359)2.49343082
42Congenital hepatic fibrosis (HP:0002612)2.46771048
43Chronic otitis media (HP:0000389)2.41898815
44Febrile seizures (HP:0002373)2.38910192
45Abnormal rod and cone electroretinograms (HP:0008323)2.33687168
46Anencephaly (HP:0002323)2.32799748
47Specific learning disability (HP:0001328)2.30686032
48Preaxial hand polydactyly (HP:0001177)2.30548743
49Facial cleft (HP:0002006)2.27856709
50Tubular atrophy (HP:0000092)2.27389993
51Central scotoma (HP:0000603)2.26788349
52Postaxial hand polydactyly (HP:0001162)2.26334991
53Morphological abnormality of the middle ear (HP:0008609)2.26029587
54Chronic bronchitis (HP:0004469)2.23251344
55Oligodactyly (hands) (HP:0001180)2.23154480
56Congenital stationary night blindness (HP:0007642)2.22200654
57Sclerocornea (HP:0000647)2.20167214
58Aplasia/Hypoplasia of the lens (HP:0008063)2.17271618
59Abnormality of the labia minora (HP:0012880)2.17123564
60Bony spicule pigmentary retinopathy (HP:0007737)2.13191444
61Oculomotor apraxia (HP:0000657)2.12839882
62Pendular nystagmus (HP:0012043)2.09746196
63Atonic seizures (HP:0010819)2.08878969
64Abnormality of macular pigmentation (HP:0008002)2.08794695
65Myokymia (HP:0002411)2.05237905
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04443308
67Protruding tongue (HP:0010808)2.02984054
68Tubulointerstitial abnormality (HP:0001969)2.00893251
69Abnormal biliary tract physiology (HP:0012439)1.98543072
70Bile duct proliferation (HP:0001408)1.98543072
71Broad foot (HP:0001769)1.97769048
72Absence seizures (HP:0002121)1.94341831
73Multicystic kidney dysplasia (HP:0000003)1.93044978
74Male pseudohermaphroditism (HP:0000037)1.91576665
75Bronchiectasis (HP:0002110)1.89673881
76Broad-based gait (HP:0002136)1.88091303
77Enlarged kidneys (HP:0000105)1.86852837
78Decreased testicular size (HP:0008734)1.85127114
79Hyperventilation (HP:0002883)1.84447716
80Median cleft lip (HP:0000161)1.83793231
81Volvulus (HP:0002580)1.83140820
82Abnormal hair whorl (HP:0010721)1.82523984
83Bifid tongue (HP:0010297)1.80043415
84Dialeptic seizures (HP:0011146)1.75962755
85Progressive cerebellar ataxia (HP:0002073)1.75175974
86Limb dystonia (HP:0002451)1.72440267
87Fibular hypoplasia (HP:0003038)1.71904416
88Sex reversal (HP:0012245)1.70962298
89Abnormal sex determination (HP:0012244)1.70962298
90Visual hallucinations (HP:0002367)1.70907777
91Septo-optic dysplasia (HP:0100842)1.70468852
92Narrow forehead (HP:0000341)1.68840193
93Epileptiform EEG discharges (HP:0011182)1.68415897
94Excessive salivation (HP:0003781)1.68363896
95Drooling (HP:0002307)1.68363896
96Nephroblastoma (Wilms tumor) (HP:0002667)1.67094989
97Stenosis of the external auditory canal (HP:0000402)1.66897053
98Scotoma (HP:0000575)1.66826970
99Renal dysplasia (HP:0000110)1.65920571
100Generalized tonic-clonic seizures (HP:0002069)1.65464403
101Prominent nasal bridge (HP:0000426)1.64875969
102Abnormality of the renal cortex (HP:0011035)1.64633851
103Micropenis (HP:0000054)1.64357909
104Abnormality of abdominal situs (HP:0011620)1.64341832
105Abdominal situs inversus (HP:0003363)1.64341832
106Furrowed tongue (HP:0000221)1.62664429
107Hip dysplasia (HP:0001385)1.62310599
108* Retinitis pigmentosa (HP:0000510)1.61942324
109Anophthalmia (HP:0000528)1.61851506
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.61460893
111Abnormality of the lacrimal duct (HP:0011481)1.61172940
112Abnormality of the renal collecting system (HP:0004742)1.61172716
113Embryonal renal neoplasm (HP:0011794)1.61047036
114Dental crowding (HP:0000678)1.60486768
115Hepatoblastoma (HP:0002884)1.59962162
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.55950528
117Asplenia (HP:0001746)1.51380859
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.49814381
119Elevated erythrocyte sedimentation rate (HP:0003565)1.48275817
120Neoplasm of the tracheobronchial system (HP:0100552)1.47755136
121Aganglionic megacolon (HP:0002251)1.47003033
122Nephropathy (HP:0000112)1.45173766
123Recurrent bacterial skin infections (HP:0005406)1.44728572
124Gastrointestinal atresia (HP:0002589)1.44397537
125Papillary thyroid carcinoma (HP:0002895)1.43705660
126Glucose intolerance (HP:0000833)1.43334018
127Alveolar cell carcinoma (HP:0006519)1.38390022
128Gonadotropin excess (HP:0000837)1.37275171
129* Recurrent bronchitis (HP:0002837)1.37113100
130Hyperactive renin-angiotensin system (HP:0000841)1.36539626
131Portal hypertension (HP:0001409)1.35293409
132Hyperkalemia (HP:0002153)1.33838178
133Rhabdomyosarcoma (HP:0002859)1.33413410
134Renal cortical cysts (HP:0000803)1.32953508
135Esophageal atresia (HP:0002032)1.32580788
136Short foot (HP:0001773)1.32450418
137Oligodactyly (HP:0012165)1.32374822
138Short tibia (HP:0005736)1.32010719
139Stage 5 chronic kidney disease (HP:0003774)1.30103702
140Nephrotic syndrome (HP:0000100)1.28639747
141Recurrent abscess formation (HP:0002722)1.27920667
142Holoprosencephaly (HP:0001360)1.27440593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.03280921
2MARK13.38209802
3EPHA43.28777711
4NTRK33.12099186
5CASK2.89884073
6PNCK2.85016923
7BCR2.65471519
8MAP3K42.47113054
9MST42.39320143
10NTRK22.33028296
11ERBB32.29613836
12MAP2K72.23853847
13MAPK132.12348188
14BMPR1B2.01949919
15KSR11.95097827
16TNIK1.90404902
17TAOK31.90296372
18CSK1.81704051
19SIK31.81578239
20TEC1.70001730
21STK161.61736063
22MINK11.61017466
23PRKD31.55014503
24MAPK151.54491323
25PLK41.46429093
26SRPK11.40372056
27CSNK1A1L1.37284149
28MKNK11.37095545
29IRAK11.33999413
30FRK1.33612989
31UHMK11.32533879
32PLK21.32302259
33BRSK21.30448271
34NLK1.28751737
35BRD41.25181504
36AKT31.24681489
37CSNK1G31.22062207
38PTK2B1.19537757
39CSNK1G21.18278865
40NEK11.17467080
41DAPK21.16655581
42MAP2K41.15480809
43BLK1.13277207
44MKNK21.11974835
45MAP3K121.09886620
46CSNK1G11.06465733
47SGK21.05750493
48PLK31.04833708
49TRIM281.04459055
50WNK11.04177018
51IRAK41.03832718
52DAPK11.03075769
53IKBKE1.02786800
54BRAF1.02480267
55TYRO31.02411611
56WNK31.01440080
57PAK31.01304799
58STK240.98066726
59ACVR1B0.95942342
60WEE10.95729715
61BCKDK0.95389568
62CDC42BPA0.94776973
63MAP3K90.94765301
64CDK30.94483037
65PRKCG0.94311475
66VRK10.93786140
67CDK50.92584267
68NUAK10.91441312
69PAK60.91348979
70BUB10.91001252
71SIK20.90957300
72BMPR20.90119164
73RIPK40.89889550
74STK100.89445212
75PLK10.88934424
76PIK3CG0.88330483
77INSRR0.87402763
78PASK0.86807419
79SGK2230.86311706
80SGK4940.86311706
81CAMK2B0.86037264
82CAMK2A0.85089865
83CDC70.83717509
84EPHB10.82867326
85FER0.82700900
86PIK3CA0.82351791
87DYRK1A0.82335046
88CCNB10.81641821
89STK390.80219317
90PDK20.80124426
91FGR0.79373807
92YES10.78652424
93GRK10.78573924
94LRRK20.78228092
95TGFBR20.77068847
96NME10.76650826
97PRPF4B0.75166264
98NEK60.74451629
99MAP3K20.72784448
100STK38L0.70303803
101EIF2AK30.69732833
102ERBB20.68034470
103PDK30.65656372
104PDK40.65656372
105DYRK30.65445972
106DYRK20.65054225
107TGFBR10.64512755
108FGFR10.61756897
109PRKAA20.61683138
110PRKCE0.61235606
111GRK50.60957489
112STK380.60521351
113TSSK60.60398483
114CSNK1E0.59966898
115MARK30.59548980
116STK40.58021768
117TYK20.54483703
118CDK190.53879347
119RPS6KA20.53777719
120IRAK20.53097558
121HCK0.52472468
122PRKCQ0.52409144
123GRK70.51933711
124PHKG20.51851645
125PHKG10.51851645
126MAP3K50.51804174
127CDK180.51719212
128BTK0.50660706
129FES0.50281382
130MAP4K20.48828591
131SGK30.48734920
132CAMKK20.48669794
133TRPM70.48485772
134MAPK100.46415955
135CDK90.46026836
136CAMKK10.45687653
137ZAK0.45263614
138RPS6KA30.44933662
139ADRBK20.44452936
140MATK0.44193947
141MELK0.43883537
142GSK3B0.43656072
143CHUK0.43277393
144PRKACB0.41849700
145CAMK40.41778776
146CDK150.41665395
147CAMK10.41526260
148MAPK90.41458045
149CDK10.41008978
150LYN0.40158814
151CDK140.39697157
152TXK0.39677295
153IKBKB0.39452064
154KIT0.38704009
155MARK20.38583868
156RAF10.38515904
157CAMK1G0.38097109
158CAMK2D0.37927509
159ZAP700.37811048
160PRKG10.37538416
161ATM0.37404506
162SGK10.36988517
163CDK80.36478487

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31197614
2Phototransduction_Homo sapiens_hsa047442.90199227
3Synaptic vesicle cycle_Homo sapiens_hsa047212.80930717
4Circadian entrainment_Homo sapiens_hsa047132.73339168
5GABAergic synapse_Homo sapiens_hsa047272.63851004
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56526102
7Olfactory transduction_Homo sapiens_hsa047402.52248528
8Morphine addiction_Homo sapiens_hsa050322.51772008
9Amphetamine addiction_Homo sapiens_hsa050312.45537716
10Taste transduction_Homo sapiens_hsa047422.33846443
11Protein export_Homo sapiens_hsa030602.30644550
12Glutamatergic synapse_Homo sapiens_hsa047242.30287175
13Insulin secretion_Homo sapiens_hsa049112.29755608
14Long-term potentiation_Homo sapiens_hsa047202.26944770
15Dopaminergic synapse_Homo sapiens_hsa047282.11723367
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09690805
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03757716
18Serotonergic synapse_Homo sapiens_hsa047261.99393033
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93999854
20Cocaine addiction_Homo sapiens_hsa050301.85227880
21Collecting duct acid secretion_Homo sapiens_hsa049661.83390094
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77253912
23Cholinergic synapse_Homo sapiens_hsa047251.66687777
24Propanoate metabolism_Homo sapiens_hsa006401.65898829
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58537412
26Proteasome_Homo sapiens_hsa030501.57871102
27Axon guidance_Homo sapiens_hsa043601.57385980
28Renin secretion_Homo sapiens_hsa049241.53242327
29Long-term depression_Homo sapiens_hsa047301.52399993
30Legionellosis_Homo sapiens_hsa051341.47414889
31Oocyte meiosis_Homo sapiens_hsa041141.46315191
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45529275
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43227603
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41802049
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41506315
36Calcium signaling pathway_Homo sapiens_hsa040201.40830782
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39379196
38Glutathione metabolism_Homo sapiens_hsa004801.36705557
39Gap junction_Homo sapiens_hsa045401.36693789
40Salivary secretion_Homo sapiens_hsa049701.35611014
41Malaria_Homo sapiens_hsa051441.35313410
42Circadian rhythm_Homo sapiens_hsa047101.30254256
43Oxytocin signaling pathway_Homo sapiens_hsa049211.29185544
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24843468
45Notch signaling pathway_Homo sapiens_hsa043301.22936158
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22362775
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21416984
48Chemical carcinogenesis_Homo sapiens_hsa052041.20991696
49Vibrio cholerae infection_Homo sapiens_hsa051101.19278591
50Melanogenesis_Homo sapiens_hsa049161.18726951
51Fanconi anemia pathway_Homo sapiens_hsa034601.16721854
52Wnt signaling pathway_Homo sapiens_hsa043101.16338369
53Regulation of autophagy_Homo sapiens_hsa041401.15048444
54cAMP signaling pathway_Homo sapiens_hsa040241.14714269
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12161274
56African trypanosomiasis_Homo sapiens_hsa051431.10638241
57Alcoholism_Homo sapiens_hsa050341.10123849
58Gastric acid secretion_Homo sapiens_hsa049711.09935411
59Leishmaniasis_Homo sapiens_hsa051401.08330423
60Huntingtons disease_Homo sapiens_hsa050161.05268015
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04365487
62Complement and coagulation cascades_Homo sapiens_hsa046101.03547499
63ABC transporters_Homo sapiens_hsa020101.03322215
64Ribosome_Homo sapiens_hsa030101.03079093
65Hematopoietic cell lineage_Homo sapiens_hsa046401.01970479
66GnRH signaling pathway_Homo sapiens_hsa049121.01090554
67Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00732080
68Basal transcription factors_Homo sapiens_hsa030220.99516689
69Cardiac muscle contraction_Homo sapiens_hsa042600.98303105
70Fatty acid biosynthesis_Homo sapiens_hsa000610.98041082
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96842098
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96825640
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.96183451
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95025453
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93644430
76TGF-beta signaling pathway_Homo sapiens_hsa043500.93613743
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92370899
78mRNA surveillance pathway_Homo sapiens_hsa030150.92194589
79Spliceosome_Homo sapiens_hsa030400.90521439
80Measles_Homo sapiens_hsa051620.90140513
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87476378
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.86992230
83Peroxisome_Homo sapiens_hsa041460.86953075
84Glucagon signaling pathway_Homo sapiens_hsa049220.86651232
85Hedgehog signaling pathway_Homo sapiens_hsa043400.86365830
86Osteoclast differentiation_Homo sapiens_hsa043800.85577096
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.84865168
88Basal cell carcinoma_Homo sapiens_hsa052170.84236912
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84177520
90RNA degradation_Homo sapiens_hsa030180.83935927
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82725106
92Staphylococcus aureus infection_Homo sapiens_hsa051500.80198410
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79949689
94Graft-versus-host disease_Homo sapiens_hsa053320.79705147
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.79452613
96p53 signaling pathway_Homo sapiens_hsa041150.79239181
97Estrogen signaling pathway_Homo sapiens_hsa049150.76482818
98Type II diabetes mellitus_Homo sapiens_hsa049300.76236239
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75778590
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.74605746
101Dorso-ventral axis formation_Homo sapiens_hsa043200.74490921
102TNF signaling pathway_Homo sapiens_hsa046680.73593569
103Arachidonic acid metabolism_Homo sapiens_hsa005900.72718703
104Purine metabolism_Homo sapiens_hsa002300.71952645
105beta-Alanine metabolism_Homo sapiens_hsa004100.71183491
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71099986
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70923855
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70844216
109Oxidative phosphorylation_Homo sapiens_hsa001900.70043156
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69399938
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68359881
112Butanoate metabolism_Homo sapiens_hsa006500.66854051
113Choline metabolism in cancer_Homo sapiens_hsa052310.66625023
114Colorectal cancer_Homo sapiens_hsa052100.64775935
115Herpes simplex infection_Homo sapiens_hsa051680.62276577
116ErbB signaling pathway_Homo sapiens_hsa040120.61471520
117Alzheimers disease_Homo sapiens_hsa050100.61373778
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60208897
119Hippo signaling pathway_Homo sapiens_hsa043900.59717667
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58294727
121RNA transport_Homo sapiens_hsa030130.57938661
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57634510
123Influenza A_Homo sapiens_hsa051640.57540103
124Mismatch repair_Homo sapiens_hsa034300.57282804
125Adherens junction_Homo sapiens_hsa045200.56872030
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.56516491
127Phenylalanine metabolism_Homo sapiens_hsa003600.56187828
128Inositol phosphate metabolism_Homo sapiens_hsa005620.56134413
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54687736
130MAPK signaling pathway_Homo sapiens_hsa040100.54639724
131Parkinsons disease_Homo sapiens_hsa050120.53245327
132Thyroid hormone synthesis_Homo sapiens_hsa049180.53243015
133Tuberculosis_Homo sapiens_hsa051520.52426760
134Allograft rejection_Homo sapiens_hsa053300.52277734
135Salmonella infection_Homo sapiens_hsa051320.51219790
136Histidine metabolism_Homo sapiens_hsa003400.51192775
137Pancreatic cancer_Homo sapiens_hsa052120.50657836
138Type I diabetes mellitus_Homo sapiens_hsa049400.50577026
139Ras signaling pathway_Homo sapiens_hsa040140.50020230
140RNA polymerase_Homo sapiens_hsa030200.48648985
141Autoimmune thyroid disease_Homo sapiens_hsa053200.47849171
142Cell cycle_Homo sapiens_hsa041100.47417082
143Glioma_Homo sapiens_hsa052140.47376406
144Endometrial cancer_Homo sapiens_hsa052130.46980115
145Dilated cardiomyopathy_Homo sapiens_hsa054140.46251049
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45168553
147Chemokine signaling pathway_Homo sapiens_hsa040620.44529548
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44065996
149Rheumatoid arthritis_Homo sapiens_hsa053230.43888714
150Nitrogen metabolism_Homo sapiens_hsa009100.42978626
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42869246
152Prostate cancer_Homo sapiens_hsa052150.42404381
153HIF-1 signaling pathway_Homo sapiens_hsa040660.41850416
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41366434
155Pancreatic secretion_Homo sapiens_hsa049720.40899158
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.39173959
157Tight junction_Homo sapiens_hsa045300.36450110
158Nucleotide excision repair_Homo sapiens_hsa034200.36373549
159Rap1 signaling pathway_Homo sapiens_hsa040150.33172035
160Non-homologous end-joining_Homo sapiens_hsa034500.32420905
161Base excision repair_Homo sapiens_hsa034100.31190074
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30781525
163Homologous recombination_Homo sapiens_hsa034400.30688184
164Ovarian steroidogenesis_Homo sapiens_hsa049130.30171341
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30153491
166Lysine degradation_Homo sapiens_hsa003100.28017314
167Non-small cell lung cancer_Homo sapiens_hsa052230.27531469
168Melanoma_Homo sapiens_hsa052180.25717780

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