RPAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of telomere maintenance via telomerase (GO:0032210)7.43114700
2polyketide metabolic process (GO:0030638)7.19796753
3doxorubicin metabolic process (GO:0044598)7.19796753
4daunorubicin metabolic process (GO:0044597)7.19796753
5protein localization to kinetochore (GO:0034501)6.14287286
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.51042374
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.23661160
8CENP-A containing nucleosome assembly (GO:0034080)5.21240209
9chromatin remodeling at centromere (GO:0031055)5.14622537
10DNA replication checkpoint (GO:0000076)5.07365523
11rRNA modification (GO:0000154)5.00518556
12mitotic sister chromatid segregation (GO:0000070)4.98147601
13rRNA methylation (GO:0031167)4.96811059
14negative regulation of cell cycle G2/M phase transition (GO:1902750)4.74310289
15protein localization to chromosome, centromeric region (GO:0071459)4.66947855
16negative regulation of epidermis development (GO:0045683)4.64007902
17histone H4-K12 acetylation (GO:0043983)4.59840543
18maintenance of protein location in nucleus (GO:0051457)4.57844127
19regulation of mammary gland epithelial cell proliferation (GO:0033599)4.57618046
20aminoglycoside antibiotic metabolic process (GO:0030647)4.57104955
21rRNA transcription (GO:0009303)4.52465207
22DNA replication-dependent nucleosome organization (GO:0034723)4.49763975
23DNA replication-dependent nucleosome assembly (GO:0006335)4.49763975
24histone H4-K8 acetylation (GO:0043982)4.48953707
25histone H4-K5 acetylation (GO:0043981)4.48953707
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.46621810
27negative regulation of telomerase activity (GO:0051974)4.45812561
28kinetochore organization (GO:0051383)4.41357977
29DNA replication-independent nucleosome organization (GO:0034724)4.40197407
30DNA replication-independent nucleosome assembly (GO:0006336)4.40197407
31regulation of MHC class I biosynthetic process (GO:0045343)4.39341733
32somite rostral/caudal axis specification (GO:0032525)4.32325562
33histone exchange (GO:0043486)4.30878216
34negative regulation of gene silencing (GO:0060969)4.25862625
35ribosome biogenesis (GO:0042254)4.25484899
36DNA strand elongation involved in DNA replication (GO:0006271)4.21955271
37establishment of integrated proviral latency (GO:0075713)4.20763945
38sister chromatid segregation (GO:0000819)4.17949046
39telomere maintenance via semi-conservative replication (GO:0032201)4.17656208
40regulation of telomere maintenance (GO:0032204)4.16616366
41negative regulation of telomere maintenance (GO:0032205)4.06989013
42DNA strand elongation (GO:0022616)4.05155609
43cullin deneddylation (GO:0010388)3.99454345
44mitotic sister chromatid cohesion (GO:0007064)3.98350092
45DNA double-strand break processing (GO:0000729)3.96858159
46formation of translation preinitiation complex (GO:0001731)3.93031290
47regulation of centriole replication (GO:0046599)3.90051673
48negative regulation of epidermal cell differentiation (GO:0045605)3.88133253
49negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.86676671
50regulation of translation in response to stress (GO:0043555)3.84136135
51DNA replication initiation (GO:0006270)3.83120557
52mitotic recombination (GO:0006312)3.80701183
53nuclear pore complex assembly (GO:0051292)3.79074213
54maturation of 5.8S rRNA (GO:0000460)3.78730551
55positive regulation of DNA-dependent DNA replication (GO:2000105)3.77492414
56DNA ligation (GO:0006266)3.76354815
57telomere maintenance via recombination (GO:0000722)3.74882807
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.74268158
59double-strand break repair via nonhomologous end joining (GO:0006303)3.72399474
60non-recombinational repair (GO:0000726)3.72399474
61regulation of mitotic spindle checkpoint (GO:1903504)3.72058758
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.72058758
63mitotic chromosome condensation (GO:0007076)3.66991801
64regulation of response to osmotic stress (GO:0047484)3.65820922
65pseudouridine synthesis (GO:0001522)3.64895674
66nuclear pore organization (GO:0006999)3.64526868
67heterochromatin organization (GO:0070828)3.63485932
68regulation of DNA endoreduplication (GO:0032875)3.63333759
69protein deneddylation (GO:0000338)3.62459782
70kinetochore assembly (GO:0051382)3.61808441
71regulation of helicase activity (GO:0051095)3.60909778
72DNA damage response, detection of DNA damage (GO:0042769)3.59352507
73regulation of cilium movement (GO:0003352)3.57009636
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.55438007
75regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55438007
76ribonucleoprotein complex biogenesis (GO:0022613)3.55247192
77mitotic metaphase plate congression (GO:0007080)3.52581718
78proteasome assembly (GO:0043248)3.51198462
79protein localization to chromosome (GO:0034502)3.49737134
80replication fork processing (GO:0031297)3.48943083
81DNA unwinding involved in DNA replication (GO:0006268)3.44113945
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.43238428
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43238428
84histone H4-K16 acetylation (GO:0043984)3.42547528
85establishment of viral latency (GO:0019043)3.42335988
86regulation of mitotic sister chromatid separation (GO:0010965)3.42322724
87regulation of mitotic sister chromatid segregation (GO:0033047)3.42322724
88regulation of sister chromatid segregation (GO:0033045)3.42322724
89IMP biosynthetic process (GO:0006188)3.42055478
90transcription from mitochondrial promoter (GO:0006390)3.40196218
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.39547268
92muscle organ morphogenesis (GO:0048644)3.38396270
93ribosome assembly (GO:0042255)3.38361197
94presynaptic membrane organization (GO:0097090)3.36837212
95establishment of chromosome localization (GO:0051303)3.36789596
96chromatin assembly (GO:0031497)3.35041195
97mitotic G2/M transition checkpoint (GO:0044818)3.32708153
98regulation of chromosome segregation (GO:0051983)3.30943013
99notochord development (GO:0030903)3.30183696
100spindle assembly checkpoint (GO:0071173)3.25840614
101histone H2A acetylation (GO:0043968)3.25445176
102DNA topological change (GO:0006265)3.25409568
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.22857884
104DNA duplex unwinding (GO:0032508)3.22454949
105nuclear envelope disassembly (GO:0051081)3.22444456
106membrane disassembly (GO:0030397)3.22444456
107DNA catabolic process, exonucleolytic (GO:0000738)3.21961742
108IMP metabolic process (GO:0046040)3.21481651
109cytidine deamination (GO:0009972)3.21303782
110cytidine metabolic process (GO:0046087)3.21303782
111cytidine catabolic process (GO:0006216)3.21303782
112meiotic chromosome segregation (GO:0045132)3.20894612
113DNA geometric change (GO:0032392)3.19319949
114regulation of centrosome cycle (GO:0046605)3.18934130
115histone mRNA metabolic process (GO:0008334)3.18888397
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18260793
117quinone metabolic process (GO:1901661)3.17756668
118telomere maintenance via telomere lengthening (GO:0010833)3.17617150
119somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.16986567
120isotype switching (GO:0045190)3.16986567
121somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.16986567
122chromatin assembly or disassembly (GO:0006333)3.16946850
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16471952
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16433948
125ATP-dependent chromatin remodeling (GO:0043044)3.16261946
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15743886
127regulation of chromatin silencing (GO:0031935)3.13017502
128regulation of telomerase activity (GO:0051972)3.10707001
129spindle assembly (GO:0051225)3.07599672
130nucleoside transmembrane transport (GO:1901642)3.06397267
131spindle checkpoint (GO:0031577)3.06274510
132microtubule depolymerization (GO:0007019)3.05573920
133mitotic spindle assembly checkpoint (GO:0007094)3.04847031
134negative regulation of DNA recombination (GO:0045910)3.04415120
135negative regulation of chromosome segregation (GO:0051985)3.04162537
136centriole replication (GO:0007099)3.03564187
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03204621
138regulation of DNA-dependent DNA replication (GO:0090329)3.03073185
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02924584
140negative regulation of sister chromatid segregation (GO:0033046)3.02924584
141negative regulation of mitotic sister chromatid separation (GO:2000816)3.02924584
142negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02924584
143nucleobase biosynthetic process (GO:0046112)3.02430406
144purine nucleobase biosynthetic process (GO:0009113)3.02015523
145postreplication repair (GO:0006301)2.99913277
146pore complex assembly (GO:0046931)2.99222028
147mitotic G2 DNA damage checkpoint (GO:0007095)2.97599447
148regulation of double-strand break repair (GO:2000779)2.97365853
149resolution of meiotic recombination intermediates (GO:0000712)2.96601117
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96353593
151mitotic nuclear envelope disassembly (GO:0007077)2.95540251
152microtubule severing (GO:0051013)2.95150897
153attachment of spindle microtubules to kinetochore (GO:0008608)2.95124835
154positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94920086
155protein neddylation (GO:0045116)2.94006342
156histone arginine methylation (GO:0034969)2.92822790
157cell fate commitment involved in formation of primary germ layer (GO:0060795)2.91612076
158mitotic spindle checkpoint (GO:0071174)2.91279388
159mitochondrial RNA metabolic process (GO:0000959)2.89330642
160ribosomal small subunit biogenesis (GO:0042274)2.87445798
161pre-miRNA processing (GO:0031054)2.83443362
162regulation of gene silencing (GO:0060968)2.82963214
163spliceosomal complex assembly (GO:0000245)2.81341322
164cellular component biogenesis (GO:0044085)2.81063640
165rRNA processing (GO:0006364)2.80214189
166metaphase plate congression (GO:0051310)2.79624415
167regulation of gene silencing by miRNA (GO:0060964)2.77439628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.50655093
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.58895330
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.58895330
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.58895330
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.40185960
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78120309
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.73600108
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.50676773
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.28849583
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.21406357
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84721726
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77193001
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63112192
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.58143560
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53223317
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.49522813
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.44011753
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38892022
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38484844
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37399918
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33638396
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32196380
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31498656
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.28095289
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28037388
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.20901393
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.11529344
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.11009518
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03903592
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01487688
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.01153300
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.00954022
33TCF3_18692474_ChIP-Seq_MESCs_Mouse1.94260054
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.93299400
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93181018
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83548841
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83531569
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80953207
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.79630464
40NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.79380358
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78512542
42EWS_26573619_Chip-Seq_HEK293_Human1.75158753
43FOXP3_21729870_ChIP-Seq_TREG_Human1.75058991
44IRF1_19129219_ChIP-ChIP_H3396_Human1.74658992
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73451689
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72378555
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70714432
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65526628
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64403879
50XRN2_22483619_ChIP-Seq_HELA_Human1.60291889
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60074347
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57356682
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56881062
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56566374
55VDR_23849224_ChIP-Seq_CD4+_Human1.55815780
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55041330
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54332960
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53665654
59FUS_26573619_Chip-Seq_HEK293_Human1.53663184
60AR_21909140_ChIP-Seq_LNCAP_Human1.52880291
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49074720
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48720513
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48131785
64MYC_18940864_ChIP-ChIP_HL60_Human1.47520264
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47107866
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47062320
67GABP_19822575_ChIP-Seq_HepG2_Human1.46782747
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46069999
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45863725
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42590697
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42174878
72TTF2_22483619_ChIP-Seq_HELA_Human1.41794229
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37521244
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35525274
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35425272
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34435844
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32261723
78DCP1A_22483619_ChIP-Seq_HELA_Human1.32153569
79POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.25529371
80TAF15_26573619_Chip-Seq_HEK293_Human1.24558496
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.20907401
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18287588
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.18134981
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16835004
85TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14816146
86NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14439419
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14343792
88IGF1R_20145208_ChIP-Seq_DFB_Human1.13928674
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.13857822
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13706515
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12452406
92E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10130756
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09652945
94NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09175060
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09103937
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07660766
97KDM5A_27292631_Chip-Seq_BREAST_Human1.06713341
98ELK1_19687146_ChIP-ChIP_HELA_Human1.06105777
99MYC_22102868_ChIP-Seq_BL_Human1.05874755
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04716353
101ZNF274_21170338_ChIP-Seq_K562_Hela1.04682180
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.03245590
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03038807
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02542749
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02463628
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01457148
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00626002
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99210146
109CIITA_25753668_ChIP-Seq_RAJI_Human0.97883954
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97321903
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96357850
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95230185
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95201569
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95189813
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.94720312
116NANOG_16518401_ChIP-PET_MESCs_Mouse0.94521651
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94179338
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.92310788
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.90810738
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88312899
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87114176
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.86354972
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86154729
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85547388
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84943896
126TFEB_21752829_ChIP-Seq_HELA_Human0.84776043
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83876299
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80930671
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80903820
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.79710634
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79535737
132VDR_22108803_ChIP-Seq_LS180_Human0.78365282
133P300_19829295_ChIP-Seq_ESCs_Human0.78147349
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77971975
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.77081296
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75021793
137SALL4_22934838_ChIP-ChIP_CD34+_Human0.71104565
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68000276
139ELF5_23300383_ChIP-Seq_T47D_Human0.67641246
140ER_23166858_ChIP-Seq_MCF-7_Human0.65355764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.87106756
2MP0004957_abnormal_blastocyst_morpholog3.81579749
3MP0008057_abnormal_DNA_replication3.42083929
4MP0009697_abnormal_copulation3.27083763
5MP0003890_abnormal_embryonic-extraembry3.22760325
6MP0003011_delayed_dark_adaptation3.05014251
7MP0004264_abnormal_extraembryonic_tissu2.95023973
8MP0005499_abnormal_olfactory_system2.90390229
9MP0005394_taste/olfaction_phenotype2.90390229
10MP0003111_abnormal_nucleus_morphology2.90243125
11MP0010094_abnormal_chromosome_stability2.79106566
12MP0003693_abnormal_embryo_hatching2.74348634
13MP0003077_abnormal_cell_cycle2.67279881
14MP0003122_maternal_imprinting2.62974232
15MP0010352_gastrointestinal_tract_polyps2.55068594
16MP0003121_genomic_imprinting2.54608523
17MP0002254_reproductive_system_inflammat2.53704529
18MP0002396_abnormal_hematopoietic_system2.42521778
19MP0003123_paternal_imprinting2.40274826
20MP0008058_abnormal_DNA_repair2.39663759
21MP0005075_abnormal_melanosome_morpholog2.36489281
22MP0006035_abnormal_mitochondrial_morpho2.19658933
23MP0002102_abnormal_ear_morphology2.07473948
24MP0003786_premature_aging2.07402383
25MP0001672_abnormal_embryogenesis/_devel2.02361966
26MP0005380_embryogenesis_phenotype2.02361966
27MP0002653_abnormal_ependyma_morphology1.92925537
28MP0005248_abnormal_Harderian_gland1.89317490
29MP0000350_abnormal_cell_proliferation1.87718191
30MP0002332_abnormal_exercise_endurance1.86005449
31MP0010030_abnormal_orbit_morphology1.80046430
32MP0008932_abnormal_embryonic_tissue1.77242089
33MP0001730_embryonic_growth_arrest1.75017930
34MP0002088_abnormal_embryonic_growth/wei1.74682731
35MP0003984_embryonic_growth_retardation1.74370369
36MP0003938_abnormal_ear_development1.72830430
37MP0004858_abnormal_nervous_system1.68365974
38MP0006072_abnormal_retinal_apoptosis1.67765984
39MP0001293_anophthalmia1.67563352
40MP0005257_abnormal_intraocular_pressure1.66738549
41MP0003941_abnormal_skin_development1.65520398
42MP0000678_abnormal_parathyroid_gland1.64427629
43MP0001529_abnormal_vocalization1.63111871
44MP0010307_abnormal_tumor_latency1.57395287
45MP0002085_abnormal_embryonic_tissue1.56166845
46MP0008007_abnormal_cellular_replicative1.54741610
47MP0003119_abnormal_digestive_system1.53272131
48MP0010234_abnormal_vibrissa_follicle1.49576696
49MP0002127_abnormal_cardiovascular_syste1.45505607
50MP0003806_abnormal_nucleotide_metabolis1.45335428
51MP0000569_abnormal_digit_pigmentation1.42853312
52MP0002086_abnormal_extraembryonic_tissu1.39020161
53MP0008789_abnormal_olfactory_epithelium1.32837808
54MP0002084_abnormal_developmental_patter1.32302216
55MP0003315_abnormal_perineum_morphology1.30897312
56MP0000049_abnormal_middle_ear1.27656656
57MP0003221_abnormal_cardiomyocyte_apopto1.26217724
58MP0001697_abnormal_embryo_size1.24096869
59MP0002277_abnormal_respiratory_mucosa1.23581038
60MP0005084_abnormal_gallbladder_morpholo1.20559350
61MP0002080_prenatal_lethality1.16444361
62MP0004197_abnormal_fetal_growth/weight/1.15945696
63MP0009672_abnormal_birth_weight1.15867571
64MP0002092_abnormal_eye_morphology1.15832714
65MP0000490_abnormal_crypts_of1.15821062
66MP0002932_abnormal_joint_morphology1.14377222
67MP0003718_maternal_effect1.13905305
68MP0000313_abnormal_cell_death1.11838688
69MP0002938_white_spotting1.10116721
70MP0009379_abnormal_foot_pigmentation1.10070588
71MP0000428_abnormal_craniofacial_morphol1.08728962
72MP0004133_heterotaxia1.06795089
73MP0003937_abnormal_limbs/digits/tail_de1.06185760
74MP0002114_abnormal_axial_skeleton1.03916093
75MP0003567_abnormal_fetal_cardiomyocyte1.02591391
76MP0002132_abnormal_respiratory_system0.99688818
77MP0000762_abnormal_tongue_morphology0.98928661
78MP0001849_ear_inflammation0.98812490
79MP0002233_abnormal_nose_morphology0.98514439
80MP0008995_early_reproductive_senescence0.98505342
81MP0002697_abnormal_eye_size0.97203249
82MP0006054_spinal_hemorrhage0.96597532
83MP0002009_preneoplasia0.95124876
84MP0002751_abnormal_autonomic_nervous0.95047035
85MP0005266_abnormal_metabolism0.94704567
86MP0004233_abnormal_muscle_weight0.90023357
87MP0003935_abnormal_craniofacial_develop0.89456723
88MP0005408_hypopigmentation0.89416175
89MP0003787_abnormal_imprinting0.89258182
90MP0001145_abnormal_male_reproductive0.88885514
91MP0003186_abnormal_redox_activity0.86625173
92MP0002210_abnormal_sex_determination0.86507229
93MP0001984_abnormal_olfaction0.85336413
94MP0000358_abnormal_cell_content/0.84103023
95MP0000372_irregular_coat_pigmentation0.83525359
96MP0002234_abnormal_pharynx_morphology0.82912032
97MP0004381_abnormal_hair_follicle0.82581306
98MP0005187_abnormal_penis_morphology0.82521412
99MP0003755_abnormal_palate_morphology0.82177652
100MP0000432_abnormal_head_morphology0.81515871
101MP0002160_abnormal_reproductive_system0.80717568
102MP0000647_abnormal_sebaceous_gland0.80606744
103MP0002090_abnormal_vision0.80306317
104MP0001188_hyperpigmentation0.80038808
105MP0001727_abnormal_embryo_implantation0.78967156
106MP0005253_abnormal_eye_physiology0.78183237
107MP0003136_yellow_coat_color0.78078115
108MP0005391_vision/eye_phenotype0.78010997
109MP0002019_abnormal_tumor_incidence0.75974465
110MP0010678_abnormal_skin_adnexa0.75772749
111MP0008770_decreased_survivor_rate0.75538435
112MP0001119_abnormal_female_reproductive0.75410203
113MP0001286_abnormal_eye_development0.75138619
114MP0002177_abnormal_outer_ear0.73424335
115MP0001324_abnormal_eye_pigmentation0.72343374
116MP0005395_other_phenotype0.72182725
117MP0002116_abnormal_craniofacial_bone0.71587115
118MP0000750_abnormal_muscle_regeneration0.71481464
119MP0003861_abnormal_nervous_system0.71229627
120MP0002269_muscular_atrophy0.70003228
121MP0008877_abnormal_DNA_methylation0.69485231
122MP0002249_abnormal_larynx_morphology0.67914118
123MP0005171_absent_coat_pigmentation0.67459874
124MP0005384_cellular_phenotype0.67155730
125MP0009703_decreased_birth_body0.66782782
126MP0000427_abnormal_hair_cycle0.64569951
127MP0006036_abnormal_mitochondrial_physio0.63918662
128MP0004084_abnormal_cardiac_muscle0.63764127
129MP0002081_perinatal_lethality0.62522827
130MP0000653_abnormal_sex_gland0.62471466
131MP0001929_abnormal_gametogenesis0.61942792
132MP0003698_abnormal_male_reproductive0.61574130
133MP0002111_abnormal_tail_morphology0.60379445
134MP0003705_abnormal_hypodermis_morpholog0.60172457
135MP0002098_abnormal_vibrissa_morphology0.59409963
136MP0004215_abnormal_myocardial_fiber0.59381744
137MP0000631_abnormal_neuroendocrine_gland0.58208443
138MP0005389_reproductive_system_phenotype0.55721393
139MP0001485_abnormal_pinna_reflex0.55295629

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.72503361
2Bilateral microphthalmos (HP:0007633)5.71013979
3Multiple enchondromatosis (HP:0005701)4.62615604
4Hypochromic microcytic anemia (HP:0004840)4.55964295
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42225361
6Abnormality of the lower motor neuron (HP:0002366)4.02077379
7Ragged-red muscle fibers (HP:0003200)3.97266389
8Chromsome breakage (HP:0040012)3.94616627
9Volvulus (HP:0002580)3.83635627
10Ependymoma (HP:0002888)3.83572425
11Nephroblastoma (Wilms tumor) (HP:0002667)3.69089556
12Astrocytoma (HP:0009592)3.68371840
13Abnormality of the astrocytes (HP:0100707)3.68371840
14Rib fusion (HP:0000902)3.66282162
15Embryonal renal neoplasm (HP:0011794)3.42175271
16Rhabdomyosarcoma (HP:0002859)3.32121587
17Medulloblastoma (HP:0002885)3.18567618
18Supernumerary spleens (HP:0009799)3.16736818
19Meckel diverticulum (HP:0002245)3.11279809
20Neoplasm of striated muscle (HP:0009728)3.11229056
21Abnormal lung lobation (HP:0002101)3.10139371
22Glioma (HP:0009733)2.97334205
23Rectovaginal fistula (HP:0000143)2.93928696
24Rectal fistula (HP:0100590)2.93928696
25Abnormality of the ileum (HP:0001549)2.93678802
26Microretrognathia (HP:0000308)2.90845674
27Hypoplasia of the fovea (HP:0007750)2.89791633
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.89791633
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.81946449
30Impulsivity (HP:0100710)2.78298999
31Bifid tongue (HP:0010297)2.75204621
32Trismus (HP:0000211)2.69212727
33Aplasia/hypoplasia of the humerus (HP:0006507)2.66386922
34Testicular atrophy (HP:0000029)2.63605309
35Amyotrophic lateral sclerosis (HP:0007354)2.61690891
36Increased nuchal translucency (HP:0010880)2.59941467
37Abnormality of the carotid arteries (HP:0005344)2.58324442
38Shawl scrotum (HP:0000049)2.56511861
39Fused cervical vertebrae (HP:0002949)2.55889856
40Atresia of the external auditory canal (HP:0000413)2.55246040
41Partial duplication of thumb phalanx (HP:0009944)2.50938995
42Colon cancer (HP:0003003)2.50763153
43Intestinal fistula (HP:0100819)2.50591436
44Abnormality of alanine metabolism (HP:0010916)2.48653644
45Hyperalaninemia (HP:0003348)2.48653644
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48653644
47Increased hepatocellular lipid droplets (HP:0006565)2.48467893
48Acute necrotizing encephalopathy (HP:0006965)2.47127240
49Duodenal stenosis (HP:0100867)2.45756683
50Small intestinal stenosis (HP:0012848)2.45756683
51Short humerus (HP:0005792)2.41376267
52Methylmalonic acidemia (HP:0002912)2.41186435
53Abnormality of glycolysis (HP:0004366)2.40575023
54Increased serum pyruvate (HP:0003542)2.40575023
55Acute encephalopathy (HP:0006846)2.40557166
56Cortical dysplasia (HP:0002539)2.39719748
57Vaginal fistula (HP:0004320)2.39199234
58Clubbing of toes (HP:0100760)2.38466986
59Abnormality of methionine metabolism (HP:0010901)2.38393844
60Malignant neoplasm of the central nervous system (HP:0100836)2.35079772
61Abnormality of the preputium (HP:0100587)2.31374774
62Pendular nystagmus (HP:0012043)2.30071463
63Tented upper lip vermilion (HP:0010804)2.29190089
64Increased CSF lactate (HP:0002490)2.28548190
65Progressive muscle weakness (HP:0003323)2.28170948
66Triphalangeal thumb (HP:0001199)2.27353581
67Facial cleft (HP:0002006)2.27325377
68Horizontal nystagmus (HP:0000666)2.26696571
69Embryonal neoplasm (HP:0002898)2.24409300
70Abnormality of the labia minora (HP:0012880)2.24381857
71Premature ovarian failure (HP:0008209)2.22053030
72Gonadotropin excess (HP:0000837)2.21212995
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.19749273
74Abnormal mitochondria in muscle tissue (HP:0008316)2.19647181
75Upper motor neuron abnormality (HP:0002127)2.19225657
76Abnormality of the fovea (HP:0000493)2.19109788
77Aplastic anemia (HP:0001915)2.18914940
78Microvesicular hepatic steatosis (HP:0001414)2.18128219
79Partial duplication of the phalanx of hand (HP:0009999)2.16381866
80Glossoptosis (HP:0000162)2.15582082
81Lipid accumulation in hepatocytes (HP:0006561)2.15122353
82Breast hypoplasia (HP:0003187)2.14778237
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.14002565
84Preauricular skin tag (HP:0000384)2.13586237
85Anomalous pulmonary venous return (HP:0010772)2.13463924
86Birth length less than 3rd percentile (HP:0003561)2.13147977
87Increased serum lactate (HP:0002151)2.12056367
88Abnormality of the salivary glands (HP:0010286)2.11773828
89Degeneration of anterior horn cells (HP:0002398)2.09670483
90Abnormality of the anterior horn cell (HP:0006802)2.09670483
91Abnormality of the phalanges of the hallux (HP:0010057)2.07765582
92Ectopic kidney (HP:0000086)2.07724698
93Reduced antithrombin III activity (HP:0001976)2.06433105
94Progressive macrocephaly (HP:0004481)2.05761937
95Inability to walk (HP:0002540)2.05576429
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05061528
97Sloping forehead (HP:0000340)2.04976280
98Abnormality of chromosome stability (HP:0003220)2.04902082
99Neoplasm of the oral cavity (HP:0100649)2.04482876
100Cerebral edema (HP:0002181)2.04134269
101Nervous tissue neoplasm (HP:0030060)2.03733508
102Neuroectodermal neoplasm (HP:0030061)2.03733508
103Neuroepithelial neoplasm (HP:0030063)2.03733508
104Tetraplegia (HP:0002445)2.02994506
105Myelodysplasia (HP:0002863)2.00592930
106Tongue fasciculations (HP:0001308)1.99517399
107Preauricular pit (HP:0004467)1.98800214
108Periauricular skin pits (HP:0100277)1.98800214
109Megaloblastic anemia (HP:0001889)1.96801336
110Congenital primary aphakia (HP:0007707)1.96784066
111Abnormality of the duodenum (HP:0002246)1.96308669
112Abnormal cartilage morphology (HP:0002763)1.95483271
113Generalized hypotonia (HP:0001290)1.94391654
114Duplication of thumb phalanx (HP:0009942)1.94377666
115Abnormality of serum amino acid levels (HP:0003112)1.92172114
116Medial flaring of the eyebrow (HP:0010747)1.92047652
117Thyroid carcinoma (HP:0002890)1.91927694
118Abnormality of chromosome segregation (HP:0002916)1.90395473
119Type I transferrin isoform profile (HP:0003642)1.89668452
1203-Methylglutaconic aciduria (HP:0003535)1.89620552
121Patellar aplasia (HP:0006443)1.88437820
122Mitochondrial inheritance (HP:0001427)1.86701622
123Difficulty climbing stairs (HP:0003551)1.86299546
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85364937
125Neoplasm of the colon (HP:0100273)1.83937038
126Neuroblastoma (HP:0003006)1.83484481
127Primitive neuroectodermal tumor (HP:0030065)1.83484481
128Neuroblastic tumors (HP:0004376)1.83484481
129Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.83484481
130Poor head control (HP:0002421)1.82983373
131Papillary thyroid carcinoma (HP:0002895)1.82719906
132Abnormality of the pulmonary veins (HP:0011718)1.81353069
133Absent radius (HP:0003974)1.79586461
134Skin tags (HP:0010609)1.79568499
135Pancreatic fibrosis (HP:0100732)1.79521431
136Astigmatism (HP:0000483)1.77505851
137Stenosis of the external auditory canal (HP:0000402)1.77469722
138Long clavicles (HP:0000890)1.77270783
139Cafe-au-lait spot (HP:0000957)1.76658908
140Genital tract atresia (HP:0001827)1.74665778
141Nephrogenic diabetes insipidus (HP:0009806)1.74374062
142Gait imbalance (HP:0002141)1.73319817
143Ovarian neoplasm (HP:0100615)1.71648192
144Vaginal atresia (HP:0000148)1.71307744
145Renal cortical cysts (HP:0000803)1.70803536
146Abnormal hair whorl (HP:0010721)1.67696718
147Abnormality of homocysteine metabolism (HP:0010919)1.66651852
148Homocystinuria (HP:0002156)1.66651852
149Absent thumb (HP:0009777)1.65648257
150Absent forearm bone (HP:0003953)1.64594723
151Aplasia involving forearm bones (HP:0009822)1.64594723
152Choanal atresia (HP:0000453)1.62479045
153Hypoplasia of the pons (HP:0012110)1.61984092
154Short tibia (HP:0005736)1.61642522
155Poor coordination (HP:0002370)1.60899119
156Lactic acidosis (HP:0003128)1.59320933
157Arteriovenous malformation (HP:0100026)1.59142274
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.57442901
159Abnormal protein glycosylation (HP:0012346)1.56808853
160Abnormal glycosylation (HP:0012345)1.56808853
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56808853
162Abnormal protein N-linked glycosylation (HP:0012347)1.56808853
163Abnormality of the pons (HP:0007361)1.56097832
164Anal atresia (HP:0002023)1.55522092
165Neoplasm of the adrenal gland (HP:0100631)1.54843948
166Biliary tract neoplasm (HP:0100574)1.54244010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.82215621
2GRK54.47855129
3GRK63.49440105
4TTK3.37942844
5BUB13.19798009
6MST43.08180992
7ADRBK23.00664855
8GRK12.87294008
9WEE12.57375436
10ERN12.47775248
11NUAK12.44410458
12PBK2.28262335
13CSF1R2.27135145
14CDC72.25158160
15TRIM282.21513721
16PLK12.01658251
17CDK71.96726012
18VRK21.93443672
19GRK71.89474291
20SRPK11.88120633
21TYRO31.87797185
22MAPK71.86417356
23CHEK21.83238649
24TAF11.76256169
25STK101.71349159
26AKT31.68146111
27MOS1.68013787
28EPHA21.66106567
29BMPR1B1.58940419
30NEK21.55625938
31TGFBR21.53722479
32BRD41.53319824
33MATK1.46933418
34PNCK1.42490522
35EIF2AK11.41094945
36BCR1.40139908
37CHEK11.26515652
38ERBB31.24447328
39BRSK21.18874713
40WNK11.17827917
41AURKA1.17181189
42WNK31.15602057
43RPS6KA41.12412566
44PLK21.11641787
45PAK41.08851998
46CAMK41.06235585
47NEK11.05216913
48LATS21.03058604
49STK31.01574362
50DYRK30.98959250
51AURKB0.96842396
52PLK40.93774952
53CSNK1G30.87646010
54PLK30.86388212
55RPS6KB20.86180860
56MARK20.85367169
57EIF2AK20.84267158
58BRAF0.82260345
59BRSK10.82252645
60LATS10.81577973
61CCNB10.80834227
62TSSK60.80235363
63ALK0.78695913
64PRKCI0.78447211
65AKT20.77665111
66PRKG20.76866939
67TNIK0.76858977
68ADRBK10.76617332
69SCYL20.74419301
70ACVR1B0.74034780
71ATR0.73836172
72STK390.72521990
73MAP3K40.71593289
74ERBB40.71581443
75CDK20.71226983
76MAP3K120.70234600
77CSNK1A1L0.69720130
78VRK10.69531983
79CDK80.68325551
80RAF10.66026927
81PASK0.65717758
82MAP2K40.62638193
83DYRK20.61900119
84MKNK20.61763011
85YES10.61479849
86NME20.59127224
87ATM0.59022953
88CDK30.58873854
89CDK40.58582411
90MKNK10.58293265
91STK40.57246147
92CSNK1G10.55634488
93TEC0.54935471
94PAK10.54319511
95CDK10.53014850
96CSNK1E0.52942585
97FRK0.50346461
98OBSCN0.46935267
99MAPK120.45279283
100MAP3K100.45218122
101HIPK20.44422318
102MAP3K140.43520679
103EIF2AK30.43339535
104PDK40.42606010
105PDK30.42606010
106PRKCG0.42432718
107MAP2K60.41666042
108CSNK1G20.40753785
109MAP2K70.40507552
110DMPK0.38967186
111NTRK10.38952222
112FGFR30.38840233
113PRKDC0.37002240
114FGFR10.36997822
115TLK10.36938860
116ARAF0.36522547
117CDK60.36368379
118OXSR10.35967622
119BCKDK0.33802880
120WNK40.33467543
121ZAK0.33125518
122CSNK2A10.32575992
123STK38L0.32027574
124STK160.31820131
125TGFBR10.30910922
126MAPKAPK30.30458479
127DYRK1A0.28909963
128BMPR20.28598260
129PRKACB0.28396829
130CDK190.27839495
131CDK90.27501485
132MAP3K80.26765936
133NME10.26735474
134GSK3B0.26714255
135MTOR0.26310336
136CSNK2A20.25495923
137PDK20.25451957
138MAPK40.25371884
139MAP4K20.24689977
140NEK60.24595876
141CDK11A0.22446651
142CSNK1D0.21752286
143CDK150.20095263
144CDK180.19845156
145MELK0.19575334

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.30608500
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.08450964
3DNA replication_Homo sapiens_hsa030303.39822564
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.23135871
5RNA transport_Homo sapiens_hsa030133.10882202
6Mismatch repair_Homo sapiens_hsa034303.07350409
7RNA polymerase_Homo sapiens_hsa030202.98023530
8Protein export_Homo sapiens_hsa030602.95275081
9Homologous recombination_Homo sapiens_hsa034402.75119697
10Ribosome_Homo sapiens_hsa030102.74941542
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71091264
12Spliceosome_Homo sapiens_hsa030402.54463938
13Cell cycle_Homo sapiens_hsa041102.43865522
14Fanconi anemia pathway_Homo sapiens_hsa034602.41778262
15Base excision repair_Homo sapiens_hsa034102.33608041
16Fructose and mannose metabolism_Homo sapiens_hsa000512.33303158
17Proteasome_Homo sapiens_hsa030502.16039910
18Pyrimidine metabolism_Homo sapiens_hsa002401.98491424
19RNA degradation_Homo sapiens_hsa030181.97246057
20Nucleotide excision repair_Homo sapiens_hsa034201.95649859
21Basal transcription factors_Homo sapiens_hsa030221.85603661
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84004367
23mRNA surveillance pathway_Homo sapiens_hsa030151.78478265
24One carbon pool by folate_Homo sapiens_hsa006701.73497135
25Propanoate metabolism_Homo sapiens_hsa006401.71459536
26Non-homologous end-joining_Homo sapiens_hsa034501.61530306
27Arachidonic acid metabolism_Homo sapiens_hsa005901.54437569
28Pyruvate metabolism_Homo sapiens_hsa006201.52438944
29Steroid biosynthesis_Homo sapiens_hsa001001.47474250
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39478417
31Galactose metabolism_Homo sapiens_hsa000521.34465707
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31816344
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26196915
34p53 signaling pathway_Homo sapiens_hsa041151.21907774
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21375702
36Purine metabolism_Homo sapiens_hsa002301.17657843
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17247256
38Linoleic acid metabolism_Homo sapiens_hsa005911.10900122
39Selenocompound metabolism_Homo sapiens_hsa004501.08913572
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05429449
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00112208
42Thyroid cancer_Homo sapiens_hsa052160.99419963
43Fatty acid elongation_Homo sapiens_hsa000620.98239866
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89246372
45Oocyte meiosis_Homo sapiens_hsa041140.88250131
46Alzheimers disease_Homo sapiens_hsa050100.86578239
47Regulation of autophagy_Homo sapiens_hsa041400.86103331
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85048025
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81339232
50mTOR signaling pathway_Homo sapiens_hsa041500.80361167
51Pentose phosphate pathway_Homo sapiens_hsa000300.75912764
52Folate biosynthesis_Homo sapiens_hsa007900.70526197
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.68814698
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67549573
55Basal cell carcinoma_Homo sapiens_hsa052170.65868723
56Huntingtons disease_Homo sapiens_hsa050160.64280867
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.59760462
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54396338
59Biosynthesis of amino acids_Homo sapiens_hsa012300.54171588
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53025127
61Colorectal cancer_Homo sapiens_hsa052100.52569348
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52531202
63MicroRNAs in cancer_Homo sapiens_hsa052060.52415863
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52252947
65Butanoate metabolism_Homo sapiens_hsa006500.48495846
66Herpes simplex infection_Homo sapiens_hsa051680.48445951
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47892984
68Hippo signaling pathway_Homo sapiens_hsa043900.47765856
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46623300
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46218618
71Epstein-Barr virus infection_Homo sapiens_hsa051690.45725120
72Inositol phosphate metabolism_Homo sapiens_hsa005620.43781146
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43596328
74Pathways in cancer_Homo sapiens_hsa052000.43446482
75Wnt signaling pathway_Homo sapiens_hsa043100.39705872
76TGF-beta signaling pathway_Homo sapiens_hsa043500.39350625
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37948698
78Fatty acid metabolism_Homo sapiens_hsa012120.37767645
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.37674057
80HTLV-I infection_Homo sapiens_hsa051660.37575622
81Hedgehog signaling pathway_Homo sapiens_hsa043400.37221301
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.37217131
83Viral carcinogenesis_Homo sapiens_hsa052030.36754493
84Carbon metabolism_Homo sapiens_hsa012000.36660453
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36016319
86Circadian rhythm_Homo sapiens_hsa047100.34024257
87Phototransduction_Homo sapiens_hsa047440.32646923
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32567051
89Ovarian steroidogenesis_Homo sapiens_hsa049130.32357706
90Metabolic pathways_Homo sapiens_hsa011000.32248738
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31872174
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30752953
93Sulfur relay system_Homo sapiens_hsa041220.30018122
94Peroxisome_Homo sapiens_hsa041460.29194583
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26481472
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26447075
97N-Glycan biosynthesis_Homo sapiens_hsa005100.26075770
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25726559
99Alcoholism_Homo sapiens_hsa050340.25234500
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23980140
101Lysine degradation_Homo sapiens_hsa003100.22651990
102Ether lipid metabolism_Homo sapiens_hsa005650.22011239
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.21873879
104Long-term depression_Homo sapiens_hsa047300.21800221
105Parkinsons disease_Homo sapiens_hsa050120.20943719
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20117965
107Acute myeloid leukemia_Homo sapiens_hsa052210.20047533
108Non-small cell lung cancer_Homo sapiens_hsa052230.19375535
109Endometrial cancer_Homo sapiens_hsa052130.19271704
110Cardiac muscle contraction_Homo sapiens_hsa042600.19252593
111beta-Alanine metabolism_Homo sapiens_hsa004100.17967810
112Legionellosis_Homo sapiens_hsa051340.17723387
113Rap1 signaling pathway_Homo sapiens_hsa040150.16166477
114Oxidative phosphorylation_Homo sapiens_hsa001900.15565416
115Nitrogen metabolism_Homo sapiens_hsa009100.15297610
116Primary immunodeficiency_Homo sapiens_hsa053400.15203414
117Apoptosis_Homo sapiens_hsa042100.14635906
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.14400805
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13274125
120Choline metabolism in cancer_Homo sapiens_hsa052310.13189894
121Adherens junction_Homo sapiens_hsa045200.12047469
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11962857
123Arginine and proline metabolism_Homo sapiens_hsa003300.11629411
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11323871
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10810728
126Systemic lupus erythematosus_Homo sapiens_hsa053220.10745831
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10249595
128Glutathione metabolism_Homo sapiens_hsa004800.10176837
129Olfactory transduction_Homo sapiens_hsa047400.09048315
130Taste transduction_Homo sapiens_hsa047420.08643669
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08557947
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08373606
133Sulfur metabolism_Homo sapiens_hsa009200.08152707
134Shigellosis_Homo sapiens_hsa051310.07444060
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07248200
136Nicotine addiction_Homo sapiens_hsa050330.06163270
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05891327
138Collecting duct acid secretion_Homo sapiens_hsa049660.04445611

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