RP1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, and two C-terminal large repetitive regions, both of which contain a high percentage of glutamine and glutamic acid residues. This protein is a retinal-specific protein. Its exact length varies among individuals due to the presence of a 16aa repeat in the first C-terminal repetitive region. The 16aa repeat is encoded by the highly polymorphic 48-bp repeat, and 1-6 copies of the 16aa repeat have been identified in normal individuals. The current reference sequence shown here has a single copy of the 16aa repeat. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Mutations in this gene cause occult macular dystrophy (OMD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of visible light (GO:0009584)9.97742805
2* visual perception (GO:0007601)8.77345289
3* sensory perception of light stimulus (GO:0050953)8.67048986
4protein-chromophore linkage (GO:0018298)8.52312667
5positive regulation of guanylate cyclase activity (GO:0031284)8.19078819
6photoreceptor cell differentiation (GO:0046530)7.81073917
7eye photoreceptor cell differentiation (GO:0001754)7.81073917
8cellular response to light stimulus (GO:0071482)7.55039338
9regulation of guanylate cyclase activity (GO:0031282)7.39552414
10detection of external stimulus (GO:0009581)7.10452397
11retina development in camera-type eye (GO:0060041)6.98975412
12detection of abiotic stimulus (GO:0009582)6.96059452
13regulation of cGMP metabolic process (GO:0030823)5.69614528
14L-fucose catabolic process (GO:0042355)5.19382147
15fucose catabolic process (GO:0019317)5.19382147
16L-fucose metabolic process (GO:0042354)5.19382147
17behavioral response to nicotine (GO:0035095)5.17569996
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.16128433
19regulation of clathrin-mediated endocytosis (GO:2000369)4.98806937
20adaptation of signaling pathway (GO:0023058)4.92272695
21cellular response to radiation (GO:0071478)4.85110124
22positive regulation of cGMP biosynthetic process (GO:0030828)4.81829943
23cell morphogenesis involved in neuron differentiation (GO:0048667)4.65940096
24nonmotile primary cilium assembly (GO:0035058)4.64397361
25regulation of cGMP biosynthetic process (GO:0030826)4.51966522
26tryptophan catabolic process (GO:0006569)4.40323153
27indole-containing compound catabolic process (GO:0042436)4.40323153
28indolalkylamine catabolic process (GO:0046218)4.40323153
29indolalkylamine metabolic process (GO:0006586)4.29884943
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.25393327
31piRNA metabolic process (GO:0034587)4.25211676
32regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.24896526
33positive regulation of cGMP metabolic process (GO:0030825)4.23358210
34kynurenine metabolic process (GO:0070189)4.17898496
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.17801262
36cellular ketone body metabolic process (GO:0046950)4.17428041
37retina layer formation (GO:0010842)4.13626136
38peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.10638511
39* sensory perception (GO:0007600)4.10263650
40prenylation (GO:0097354)4.02361287
41protein prenylation (GO:0018342)4.02361287
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99228014
43estrogen biosynthetic process (GO:0006703)3.95363690
44tryptophan metabolic process (GO:0006568)3.91729091
45response to light stimulus (GO:0009416)3.90512024
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90129934
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.89997969
48negative regulation of receptor-mediated endocytosis (GO:0048261)3.83749381
49detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.77407867
50regulation of voltage-gated calcium channel activity (GO:1901385)3.77323595
51ketone body metabolic process (GO:1902224)3.74445380
52DNA deamination (GO:0045006)3.70016856
53mannosylation (GO:0097502)3.69095537
54retina homeostasis (GO:0001895)3.66255952
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64258569
56preassembly of GPI anchor in ER membrane (GO:0016254)3.53826224
57neural tube formation (GO:0001841)3.48267598
58* neuron development (GO:0048666)3.45733021
59cilium or flagellum-dependent cell motility (GO:0001539)3.45291507
60protein localization to synapse (GO:0035418)3.44896703
61phosphatidylinositol acyl-chain remodeling (GO:0036149)3.43938650
62DNA methylation involved in gamete generation (GO:0043046)3.43430526
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37340987
64CDP-diacylglycerol biosynthetic process (GO:0016024)3.36597648
65synaptic vesicle maturation (GO:0016188)3.33084820
66platelet dense granule organization (GO:0060155)3.28126262
67gamma-aminobutyric acid transport (GO:0015812)3.23159492
68cellular biogenic amine catabolic process (GO:0042402)3.18777449
69amine catabolic process (GO:0009310)3.18777449
70indole-containing compound metabolic process (GO:0042430)3.17722904
71respiratory chain complex IV assembly (GO:0008535)3.16753062
72auditory receptor cell stereocilium organization (GO:0060088)3.12721809
73retinoid metabolic process (GO:0001523)3.08866909
74CDP-diacylglycerol metabolic process (GO:0046341)3.08822369
75reflex (GO:0060004)3.08774993
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08186304
77protein K11-linked deubiquitination (GO:0035871)3.07825190
78protein polyglutamylation (GO:0018095)3.05496598
79phosphatidylserine acyl-chain remodeling (GO:0036150)3.04848682
80lipoprotein transport (GO:0042953)3.03890455
81axoneme assembly (GO:0035082)3.03426133
82multicellular organism reproduction (GO:0032504)3.01594861
83membrane hyperpolarization (GO:0060081)3.00131870
84rRNA catabolic process (GO:0016075)2.99657242
85synaptic vesicle docking involved in exocytosis (GO:0016081)2.97872884
86sulfation (GO:0051923)2.96118159
87positive regulation of neurotransmitter transport (GO:0051590)2.92898718
88phospholipid translocation (GO:0045332)2.91028517
89lipid translocation (GO:0034204)2.91028517
90diterpenoid metabolic process (GO:0016101)2.86742543
91regulation of meiosis I (GO:0060631)2.86488874
92cytochrome complex assembly (GO:0017004)2.86167793
93cAMP catabolic process (GO:0006198)2.85837847
94short-term memory (GO:0007614)2.83336412
95positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.79233089
96cilium morphogenesis (GO:0060271)2.78554316
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.78264279
98proline transport (GO:0015824)2.77494410
99regulation of cilium movement (GO:0003352)2.76353928
100water-soluble vitamin biosynthetic process (GO:0042364)2.76202285
101epithelial cilium movement (GO:0003351)2.75054814
102chemosensory behavior (GO:0007635)2.74742401
103double-strand break repair via homologous recombination (GO:0000724)2.73763628
104reciprocal meiotic recombination (GO:0007131)2.73581893
105reciprocal DNA recombination (GO:0035825)2.73581893
106post-embryonic morphogenesis (GO:0009886)2.73523862
107signal peptide processing (GO:0006465)2.72624192
108recombinational repair (GO:0000725)2.72512353
109regulation of hippo signaling (GO:0035330)2.72051837
110positive regulation of sodium ion transmembrane transport (GO:1902307)2.71362615
111cellular response to ATP (GO:0071318)2.70576136
112RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69612325
113negative regulation of mast cell activation (GO:0033004)2.69292846
114inner ear receptor stereocilium organization (GO:0060122)2.69230267
115cornea development in camera-type eye (GO:0061303)2.67292894
116response to radiation (GO:0009314)2.65592514
117behavioral response to ethanol (GO:0048149)2.65323933
118phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64701714
119neuronal action potential (GO:0019228)2.62084380
120regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.61958026
121regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.61958026
122terpenoid metabolic process (GO:0006721)2.61918745
123regulation of glucokinase activity (GO:0033131)2.60134982
124regulation of hexokinase activity (GO:1903299)2.60134982
125cyclic nucleotide catabolic process (GO:0009214)2.60083312
126primary amino compound metabolic process (GO:1901160)2.59693375
127adenosine metabolic process (GO:0046085)2.58577070
128cell wall macromolecule catabolic process (GO:0016998)2.58130397
129protein-cofactor linkage (GO:0018065)2.57780539
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56931776
131negative regulation of telomere maintenance (GO:0032205)2.55121497
132synaptic transmission, cholinergic (GO:0007271)2.55085852
133benzene-containing compound metabolic process (GO:0042537)2.54915746
134thyroid hormone metabolic process (GO:0042403)2.54915096
135negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.54865385
136response to histamine (GO:0034776)2.54305579
137vitamin A metabolic process (GO:0006776)2.53185435
138retinol metabolic process (GO:0042572)2.53123930
139fucosylation (GO:0036065)2.51941105
140cell wall macromolecule metabolic process (GO:0044036)2.51765341
141protein heterotetramerization (GO:0051290)2.51293812
142C-terminal protein amino acid modification (GO:0018410)2.50616155
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50412666
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50412666
145protein complex biogenesis (GO:0070271)2.50071591
146GPI anchor metabolic process (GO:0006505)2.50066661
147cilium organization (GO:0044782)2.48756921
148ubiquinone biosynthetic process (GO:0006744)2.48642287
149aromatic amino acid family catabolic process (GO:0009074)2.48024855
150sperm motility (GO:0030317)2.47944320
151regulation of action potential (GO:0098900)2.47912685
152regulation of penile erection (GO:0060405)2.46922928
153DNA double-strand break processing (GO:0000729)2.46261369
154cellular response to abiotic stimulus (GO:0071214)2.44976935
155spinal cord motor neuron differentiation (GO:0021522)2.44932541
156amino acid salvage (GO:0043102)2.44603492
157L-methionine biosynthetic process (GO:0071265)2.44603492
158arachidonic acid secretion (GO:0050482)2.43053129
159icosanoid secretion (GO:0032309)2.43053129
160dopamine receptor signaling pathway (GO:0007212)2.42531630
161sodium ion export (GO:0071436)2.42436755
162cellular potassium ion homeostasis (GO:0030007)2.40450663
163lactate metabolic process (GO:0006089)2.40429748
164negative regulation of cation channel activity (GO:2001258)2.40200735
165negative regulation of transcription regulatory region DNA binding (GO:2000678)2.39692940
166positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.39112263
167establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.38957760
168mitochondrion transport along microtubule (GO:0047497)2.38957760
169negative regulation of calcium ion transmembrane transport (GO:1903170)2.34302389
170negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.34302389
171potassium ion homeostasis (GO:0055075)2.32642251
172glutamate secretion (GO:0014047)2.29530250
173response to pheromone (GO:0019236)2.27900158
174positive regulation of vesicle fusion (GO:0031340)2.26985056
175regulation of rhodopsin mediated signaling pathway (GO:0022400)17.9704319
176rhodopsin mediated signaling pathway (GO:0016056)17.6458710
177retinal cone cell development (GO:0046549)13.8840727
178eye photoreceptor cell development (GO:0042462)11.9926035
179* photoreceptor cell development (GO:0042461)11.7876070
180retinal rod cell development (GO:0046548)11.4257449
181* photoreceptor cell maintenance (GO:0045494)11.2346712
182phototransduction (GO:0007602)10.7510395
183GMP metabolic process (GO:0046037)10.5791191
184phototransduction, visible light (GO:0007603)10.5535852
185detection of light stimulus involved in visual perception (GO:0050908)10.4294484
186detection of light stimulus involved in sensory perception (GO:0050962)10.4294484
187detection of light stimulus (GO:0009583)10.1541305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.18693464
2ZNF274_21170338_ChIP-Seq_K562_Hela4.00109632
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93097585
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92067719
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58386727
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45141664
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36818051
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.32952778
9GBX2_23144817_ChIP-Seq_PC3_Human2.27045882
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19662059
11DROSHA_22980978_ChIP-Seq_HELA_Human2.18697220
12TAF15_26573619_Chip-Seq_HEK293_Human2.11629179
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.11188624
14VDR_22108803_ChIP-Seq_LS180_Human2.10284036
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05130437
16BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.02451190
17ER_23166858_ChIP-Seq_MCF-7_Human2.00116056
18EZH2_22144423_ChIP-Seq_EOC_Human1.98667617
19FUS_26573619_Chip-Seq_HEK293_Human1.98418475
20KDM2B_26808549_Chip-Seq_K562_Human1.92657797
21EWS_26573619_Chip-Seq_HEK293_Human1.87713937
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85071268
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83949247
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83566649
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78956105
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77480777
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77356662
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75894060
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.75376981
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74850148
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.74654067
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.72079147
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.71400034
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70837462
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67706634
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.67649258
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66326533
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63469947
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63370675
40REST_21632747_ChIP-Seq_MESCs_Mouse1.62034430
41CBP_20019798_ChIP-Seq_JUKART_Human1.61462292
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61462292
43TP53_22573176_ChIP-Seq_HFKS_Human1.61108244
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60881558
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60875194
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.59746954
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58384413
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58384413
49AR_21572438_ChIP-Seq_LNCaP_Human1.57092876
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55521445
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55237447
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55237447
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.52300635
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49711141
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49232911
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48483560
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.48115090
58* AR_19668381_ChIP-Seq_PC3_Human1.47094940
59CTCF_27219007_Chip-Seq_Bcells_Human1.46368433
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44921267
61AR_25329375_ChIP-Seq_VCAP_Human1.44114253
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.44028954
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.43927543
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.42390079
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42390079
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41987634
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.40632900
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.39587735
69NANOG_19829295_ChIP-Seq_ESCs_Human1.39051071
70SOX2_19829295_ChIP-Seq_ESCs_Human1.39051071
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38891588
72IRF1_19129219_ChIP-ChIP_H3396_Human1.38870233
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38488994
74SMC4_20622854_ChIP-Seq_HELA_Human1.38362705
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37845511
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35976115
77TCF4_22108803_ChIP-Seq_LS180_Human1.34834819
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34285963
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33474969
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.32755289
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.32390231
82TBL1_22424771_ChIP-Seq_293T_Human1.32024412
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31104478
84SMAD4_21799915_ChIP-Seq_A2780_Human1.31019635
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30639910
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.30095140
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.29629844
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28367629
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28315081
90CREB1_26743006_Chip-Seq_LNCaP_Human1.28080018
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.27526460
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.27441009
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26114669
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25075701
95MYC_18940864_ChIP-ChIP_HL60_Human1.23467234
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23162121
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.21681867
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.21589262
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21129076
100HOXB7_26014856_ChIP-Seq_BT474_Human1.21056787
101IRF8_22096565_ChIP-ChIP_GC-B_Human1.20808783
102AR_20517297_ChIP-Seq_VCAP_Human1.20784662
103RUNX2_22187159_ChIP-Seq_PCA_Human1.20243541
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.17485201
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17475637
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17090166
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15795340
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.15359023
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.15337162
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14852742
111CDX2_22108803_ChIP-Seq_LS180_Human1.14550032
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13958989
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.13497455
114STAT3_23295773_ChIP-Seq_U87_Human1.12963331
115BCAT_22108803_ChIP-Seq_LS180_Human1.12506363
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11976746
117EGR1_19032775_ChIP-ChIP_M12_Human1.11810211
118TAF2_19829295_ChIP-Seq_ESCs_Human1.11702393
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.11688269
120* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11316888
121NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.10158439
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10137766
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10118060
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10025224
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09123824
126MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08864451
127IGF1R_20145208_ChIP-Seq_DFB_Human1.08785427
128SMAD4_21741376_ChIP-Seq_HESCs_Human1.07820152
129P68_20966046_ChIP-Seq_HELA_Human1.06598858
130ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04942021
131MYC_19829295_ChIP-Seq_ESCs_Human1.04338225
132ERA_21632823_ChIP-Seq_H3396_Human1.03801821
133JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02277198
134DPY_21335234_ChIP-Seq_ESCs_Mouse1.02203360
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01758645
136SMAD4_21741376_ChIP-Seq_ESCs_Human1.01691160
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01676710
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.01339630
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00992957
140KDM2B_26808549_Chip-Seq_DND41_Human1.00971042
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.00614794
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99997675
143SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99974654
144RNF2_27304074_Chip-Seq_NSC_Mouse0.99574997
145* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98947498
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98687177
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.98473431
148P53_22387025_ChIP-Seq_ESCs_Mouse0.98445107
149CTCF_20526341_ChIP-Seq_ESCs_Human0.98209231
150SA1_27219007_Chip-Seq_Bcells_Human0.97671312
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97650580
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96829144
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96753640
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.96480298
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.96334901
156OCT4_19829295_ChIP-Seq_ESCs_Human0.96286380
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95728329
158EST1_17652178_ChIP-ChIP_JURKAT_Human0.95709539
159* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95682922
160TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95564957
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94900810
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.94454485
163* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94172174
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93319417
165CBP_21632823_ChIP-Seq_H3396_Human0.93216904
166WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92628579
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90849829
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90741448
169SMAD3_21741376_ChIP-Seq_ESCs_Human0.89485541
170NCOR_22424771_ChIP-Seq_293T_Human0.89445174
171KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87987771
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87796430
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.87676642
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86034018
175TCF4_23295773_ChIP-Seq_U87_Human0.85912454
176GF1_26923725_Chip-Seq_HPCs_Mouse0.85887150
177FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85244037
178P300_19829295_ChIP-Seq_ESCs_Human0.85047113
179MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85004919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.30216283
2MP0005253_abnormal_eye_physiology6.88299468
3MP0006072_abnormal_retinal_apoptosis6.64066240
4* MP0005195_abnormal_posterior_eye3.86429982
5MP0001324_abnormal_eye_pigmentation3.70818574
6MP0003950_abnormal_plasma_membrane3.50786690
7MP0005391_vision/eye_phenotype3.39876021
8MP0003195_calcinosis3.37293678
9MP0008877_abnormal_DNA_methylation3.22108836
10MP0002638_abnormal_pupillary_reflex2.88264753
11MP0002090_abnormal_vision2.80375708
12* MP0002229_neurodegeneration2.52293206
13MP0005423_abnormal_somatic_nervous2.49545848
14MP0005645_abnormal_hypothalamus_physiol2.32095130
15MP0000569_abnormal_digit_pigmentation2.27848846
16MP0002837_dystrophic_cardiac_calcinosis2.26446557
17MP0002138_abnormal_hepatobiliary_system2.21136703
18MP0000372_irregular_coat_pigmentation2.19850943
19MP0005646_abnormal_pituitary_gland2.18399973
20MP0001501_abnormal_sleep_pattern2.12278578
21MP0002876_abnormal_thyroid_physiology2.01523447
22MP0001764_abnormal_homeostasis2.00610639
23MP0003011_delayed_dark_adaptation11.3311568
24MP0003646_muscle_fatigue1.93253258
25MP0002653_abnormal_ependyma_morphology1.89869869
26* MP0002752_abnormal_somatic_nervous1.89578235
27MP0002736_abnormal_nociception_after1.85613867
28MP0008875_abnormal_xenobiotic_pharmacok1.82287396
29MP0008872_abnormal_physiological_respon1.81735756
30MP0003136_yellow_coat_color1.72987261
31MP0001986_abnormal_taste_sensitivity1.72640323
32MP0003787_abnormal_imprinting1.66283894
33MP0005377_hearing/vestibular/ear_phenot1.66264549
34MP0003878_abnormal_ear_physiology1.66264549
35MP0001485_abnormal_pinna_reflex1.65366272
36MP0002735_abnormal_chemical_nociception1.56249441
37MP0006276_abnormal_autonomic_nervous1.51227534
38MP0005174_abnormal_tail_pigmentation1.50464763
39MP0005084_abnormal_gallbladder_morpholo1.43555795
40* MP0002882_abnormal_neuron_morphology1.39150409
41MP0004147_increased_porphyrin_level1.38695229
42MP0001502_abnormal_circadian_rhythm1.35244393
43MP0004019_abnormal_vitamin_homeostasis1.33615587
44MP0001970_abnormal_pain_threshold1.30789510
45MP0000427_abnormal_hair_cycle1.28679240
46MP0005410_abnormal_fertilization1.27474163
47MP0002733_abnormal_thermal_nociception1.26746373
48MP0003718_maternal_effect1.23456887
49MP0002938_white_spotting1.22470515
50MP0004885_abnormal_endolymph1.21778380
51MP0008775_abnormal_heart_ventricle1.20617054
52MP0000383_abnormal_hair_follicle1.18376614
53MP0005085_abnormal_gallbladder_physiolo1.18166960
54MP0006292_abnormal_olfactory_placode1.14095816
55MP0005389_reproductive_system_phenotype1.10738032
56MP0004133_heterotaxia1.09217439
57MP0002160_abnormal_reproductive_system1.05716651
58MP0005197_abnormal_uvea_morphology1.03835988
59MP0004270_analgesia1.03815684
60MP0002095_abnormal_skin_pigmentation1.03768471
61MP0005499_abnormal_olfactory_system0.99927126
62MP0005394_taste/olfaction_phenotype0.99927126
63MP0000230_abnormal_systemic_arterial0.98398664
64MP0008995_early_reproductive_senescence0.96143590
65MP0003698_abnormal_male_reproductive0.95998007
66MP0004233_abnormal_muscle_weight0.95491004
67MP0002693_abnormal_pancreas_physiology0.94155233
68MP0005075_abnormal_melanosome_morpholog0.93608698
69MP0001984_abnormal_olfaction0.90917133
70MP0005167_abnormal_blood-brain_barrier0.89602458
71MP0009764_decreased_sensitivity_to0.88731148
72MP0003634_abnormal_glial_cell0.87714338
73MP0003137_abnormal_impulse_conducting0.86583221
74MP0005171_absent_coat_pigmentation0.86486134
75MP0005187_abnormal_penis_morphology0.85209068
76MP0001929_abnormal_gametogenesis0.85187249
77MP0008789_abnormal_olfactory_epithelium0.85055087
78MP0005332_abnormal_amino_acid0.84678132
79MP0010329_abnormal_lipoprotein_level0.84563023
80MP0001486_abnormal_startle_reflex0.82869162
81MP0002127_abnormal_cardiovascular_syste0.80834529
82MP0002163_abnormal_gland_morphology0.79738573
83MP0000015_abnormal_ear_pigmentation0.77708942
84MP0001905_abnormal_dopamine_level0.77678669
85MP0001756_abnormal_urination0.77357849
86MP0005379_endocrine/exocrine_gland_phen0.76789432
87MP0001919_abnormal_reproductive_system0.76703185
88MP0005671_abnormal_response_to0.75871883
89MP0000538_abnormal_urinary_bladder0.75782361
90MP0003880_abnormal_central_pattern0.75671719
91MP0002272_abnormal_nervous_system0.74358080
92MP0004859_abnormal_synaptic_plasticity0.72274972
93MP0002332_abnormal_exercise_endurance0.70621289
94MP0001286_abnormal_eye_development0.66234864
95MP0002064_seizures0.58517079
96MP0003635_abnormal_synaptic_transmissio0.57845234
97MP0009046_muscle_twitch0.56486179
98MP0002734_abnormal_mechanical_nocicepti0.55373065
99MP0000465_gastrointestinal_hemorrhage0.48867839
100MP0005248_abnormal_Harderian_gland0.48842952
101MP0002697_abnormal_eye_size0.47642695
102MP0001963_abnormal_hearing_physiology0.44344871
103MP0005376_homeostasis/metabolism_phenot0.41808816
104MP0002063_abnormal_learning/memory/cond0.41552771
105MP0002067_abnormal_sensory_capabilities0.40391008
106MP0003890_abnormal_embryonic-extraembry0.39166472
107MP0004215_abnormal_myocardial_fiber0.35806540
108MP0009745_abnormal_behavioral_response0.34818027
109MP0009780_abnormal_chondrocyte_physiolo0.34671780
110MP0004924_abnormal_behavior0.34048259
111MP0005386_behavior/neurological_phenoty0.34048259
112MP0002572_abnormal_emotion/affect_behav0.32900081
113MP0005193_abnormal_anterior_eye0.32065004
114MP0001968_abnormal_touch/_nociception0.31109751
115MP0010030_abnormal_orbit_morphology0.30819208
116MP0004085_abnormal_heartbeat0.29831497
117MP0004742_abnormal_vestibular_system0.29668169
118MP0001915_intracranial_hemorrhage0.29592153
119MP0004782_abnormal_surfactant_physiolog0.28777721
120MP0002152_abnormal_brain_morphology0.28472719
121MP0002184_abnormal_innervation0.28465294
122MP0004043_abnormal_pH_regulation0.27898873
123MP0000631_abnormal_neuroendocrine_gland0.27502294
124MP0000778_abnormal_nervous_system0.26869296
125MP0004811_abnormal_neuron_physiology0.26438092
126MP0008569_lethality_at_weaning0.26211433
127MP0002102_abnormal_ear_morphology0.24774079
128MP0003633_abnormal_nervous_system0.24709421
129MP0005595_abnormal_vascular_smooth0.24417387
130MP0005620_abnormal_muscle_contractility0.24249752
131MP0002066_abnormal_motor_capabilities/c0.24093603
132MP0005076_abnormal_cell_differentiation0.24043646
133MP0003632_abnormal_nervous_system0.22798290
134MP0003045_fibrosis0.22249079
135MP0008961_abnormal_basal_metabolism0.21908372
136MP0002234_abnormal_pharynx_morphology0.21044275
137MP0004145_abnormal_muscle_electrophysio0.20700646
138MP0000026_abnormal_inner_ear0.20123613
139MP0003705_abnormal_hypodermis_morpholog0.19445289
140MP0003631_nervous_system_phenotype0.18516210
141MP0004142_abnormal_muscle_tone0.17769157
142MP0003943_abnormal_hepatobiliary_system0.17574738
143MP0002928_abnormal_bile_duct0.17063983
144MP0001293_anophthalmia0.16928080
145MP0002909_abnormal_adrenal_gland0.16056695
146MP0010386_abnormal_urinary_bladder0.15726633
147MP0000955_abnormal_spinal_cord0.15217586
148MP0001177_atelectasis0.15207866
149MP0003252_abnormal_bile_duct0.14798790
150MP0002092_abnormal_eye_morphology0.13951643
151MP0002557_abnormal_social/conspecific_i0.12813675
152MP0003861_abnormal_nervous_system0.12670975
153MP0000751_myopathy0.11411907
154MP0003638_abnormal_response/metabolism_0.11330747
155MP0008004_abnormal_stomach_pH0.10915150
156MP0002108_abnormal_muscle_morphology0.09987511
157MP0005257_abnormal_intraocular_pressure0.09946599

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)9.41330044
2Pigmentary retinal degeneration (HP:0001146)9.17588722
3Central scotoma (HP:0000603)8.64894971
4Pendular nystagmus (HP:0012043)8.40976137
5Scotoma (HP:0000575)7.72789897
6Abolished electroretinogram (ERG) (HP:0000550)7.54901322
7Abnormality of macular pigmentation (HP:0008002)7.32534700
8Attenuation of retinal blood vessels (HP:0007843)7.10388795
9Dyschromatopsia (HP:0007641)6.99226090
10Decreased central vision (HP:0007663)6.30695937
11Type II diabetes mellitus (HP:0005978)5.71722147
12Posterior subcapsular cataract (HP:0007787)5.46789584
13Photophobia (HP:0000613)5.46083225
14Macular degeneration (HP:0000608)5.33782900
15Increased corneal curvature (HP:0100692)5.33344897
16Keratoconus (HP:0000563)5.33344897
17Vitreoretinal degeneration (HP:0000655)5.20851411
18Cone-rod dystrophy (HP:0000548)5.08354592
19Severe visual impairment (HP:0001141)4.97734346
20Constricted visual fields (HP:0001133)4.67249963
21Retinitis pigmentosa (HP:0000510)4.26769833
22Choroideremia (HP:0001139)4.25475093
23Type II lissencephaly (HP:0007260)3.79649393
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.73334535
25Nephronophthisis (HP:0000090)3.65893272
26Abnormality of the renal cortex (HP:0011035)3.57667967
27Abnormality of the renal medulla (HP:0100957)3.31951007
28Subcapsular cataract (HP:0000523)3.31289750
29Chronic hepatic failure (HP:0100626)3.21710807
30Abnormal drinking behavior (HP:0030082)3.16081168
31Polydipsia (HP:0001959)3.16081168
32Retinal atrophy (HP:0001105)3.09180926
33Hyperventilation (HP:0002883)2.96271223
34Renal cortical cysts (HP:0000803)2.79346408
35Congenital, generalized hypertrichosis (HP:0004540)2.78563653
36Tubular atrophy (HP:0000092)2.64581034
37Wide nasal bridge (HP:0000431)2.56316370
38Inability to walk (HP:0002540)2.54629196
39Large for gestational age (HP:0001520)2.54516340
40Polyuria (HP:0000103)2.52886818
41Hypothermia (HP:0002045)2.50912598
42* Progressive visual loss (HP:0000529)2.50030718
43Gaze-evoked nystagmus (HP:0000640)2.49142479
44Abnormal biliary tract physiology (HP:0012439)2.39089086
45Bile duct proliferation (HP:0001408)2.39089086
46Optic disc pallor (HP:0000543)2.32753116
47Congenital sensorineural hearing impairment (HP:0008527)2.27398732
48Hypomagnesemia (HP:0002917)2.26918474
49Progressive inability to walk (HP:0002505)2.24896080
50Retinal dysplasia (HP:0007973)2.21283221
51Concave nail (HP:0001598)2.20863180
52Abnormality of alanine metabolism (HP:0010916)2.11066838
53Hyperalaninemia (HP:0003348)2.11066838
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11066838
55Decreased circulating renin level (HP:0003351)2.10845832
56Methylmalonic aciduria (HP:0012120)2.09980383
57Absent/shortened dynein arms (HP:0200106)2.09903424
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.09903424
59Gait imbalance (HP:0002141)2.08287077
60Lissencephaly (HP:0001339)2.07806542
61Severe muscular hypotonia (HP:0006829)2.07533410
62Stomach cancer (HP:0012126)2.06310119
63Thyroid-stimulating hormone excess (HP:0002925)2.06141228
64Congenital primary aphakia (HP:0007707)2.05763424
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.05274231
66Abnormal urine output (HP:0012590)2.01618813
67Optic nerve hypoplasia (HP:0000609)2.01569418
68Male pseudohermaphroditism (HP:0000037)2.01540800
69Congenital stationary night blindness (HP:0007642)13.8555474
70Bony spicule pigmentary retinopathy (HP:0007737)11.6019342
71Absent rod-and cone-mediated responses on ERG (HP:0007688)11.3678208
72Abnormal rod and cone electroretinograms (HP:0008323)10.6016771
73Fair hair (HP:0002286)1.98575576
74Increased CSF lactate (HP:0002490)1.94998219
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.94498950
76Clumsiness (HP:0002312)1.92866777
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91830675
78Intestinal atresia (HP:0011100)1.90381903
79Postaxial foot polydactyly (HP:0001830)1.88506064
80Interstitial pulmonary disease (HP:0006530)1.88356552
81Ketosis (HP:0001946)1.85518468
82Polar cataract (HP:0010696)1.84600701
83Small hand (HP:0200055)1.84509683
84Hepatic necrosis (HP:0002605)1.84030797
85Abnormal respiratory motile cilium morphology (HP:0005938)1.82512425
86Abnormal respiratory epithelium morphology (HP:0012253)1.82512425
87Ketoacidosis (HP:0001993)1.81993246
88Nephrogenic diabetes insipidus (HP:0009806)1.81110203
89Tetany (HP:0001281)1.80360741
90Hypoplasia of the pons (HP:0012110)1.79638656
91Methylmalonic acidemia (HP:0002912)1.78727647
92Pachygyria (HP:0001302)1.78400460
93Asplenia (HP:0001746)1.77567105
94Mitochondrial inheritance (HP:0001427)1.77279559
95Occipital encephalocele (HP:0002085)1.76658454
96Abnormality of renal excretion (HP:0011036)1.75997257
97Abnormality of the pons (HP:0007361)1.75005145
98Stomatitis (HP:0010280)1.74694561
99Hyperglycinuria (HP:0003108)1.73939526
100Hemiparesis (HP:0001269)1.73645384
101Oligodactyly (hands) (HP:0001180)1.71869113
102Acute necrotizing encephalopathy (HP:0006965)1.71567864
103Hepatocellular necrosis (HP:0001404)1.70876515
104Medial flaring of the eyebrow (HP:0010747)1.70156957
105Optic atrophy (HP:0000648)1.61519020
106Poor coordination (HP:0002370)1.56953278
107Horizontal nystagmus (HP:0000666)1.48316508
108True hermaphroditism (HP:0010459)1.45738343
109Vaginal atresia (HP:0000148)1.42017065
110Severe Myopia (HP:0011003)1.39034597
111Pancreatic fibrosis (HP:0100732)1.36158185
112Genital tract atresia (HP:0001827)1.35752573
113Aplasia/Hypoplasia of the lens (HP:0008063)1.23888856
114Abnormality of the fovea (HP:0000493)1.20652971
115Cystic liver disease (HP:0006706)1.18607552
116Visual hallucinations (HP:0002367)1.15128655
117Dysdiadochokinesis (HP:0002075)1.14784919
118Retinal detachment (HP:0000541)1.13376033
119Hypoplasia of the fovea (HP:0007750)1.12852809
120Aplasia/Hypoplasia of the fovea (HP:0008060)1.12852809
121Recurrent sinusitis (HP:0011108)1.10714544
122Epileptic encephalopathy (HP:0200134)1.09257223
123Pancreatic cysts (HP:0001737)1.09008382
124Sclerocornea (HP:0000647)1.06968721
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.04524567
126Febrile seizures (HP:0002373)0.96607319
127Astigmatism (HP:0000483)0.96372598
128Aplasia/Hypoplasia of the macula (HP:0008059)0.94788827
129Chorioretinal coloboma (HP:0000567)0.92691292
130Hypermetropia (HP:0000540)0.90601587
131Aplasia/Hypoplasia affecting the retina (HP:0008061)0.89621890
132Furrowed tongue (HP:0000221)0.87589802
133Specific learning disability (HP:0001328)0.85456409
134Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.84984721
135Left ventricular hypertrophy (HP:0001712)0.83621423
136Truncal ataxia (HP:0002078)0.82606217
137Cerebellar dysplasia (HP:0007033)0.81502486
138Broad foot (HP:0001769)0.80815169
139Abnormality of the lower motor neuron (HP:0002366)0.79026091
140Progressive cerebellar ataxia (HP:0002073)0.78416591
141Decreased testicular size (HP:0008734)0.77785669
142Asthma (HP:0002099)0.77254338
143Prolonged QT interval (HP:0001657)0.72266187
144Anencephaly (HP:0002323)0.70742287
145Macroorchidism (HP:0000053)0.68853352
146Lymphopenia (HP:0001888)0.64928515
147Abnormality of midbrain morphology (HP:0002418)0.64051078
148Molar tooth sign on MRI (HP:0002419)0.64051078
149Supranuclear gaze palsy (HP:0000605)0.63739431
150Genetic anticipation (HP:0003743)0.63504312
151Abnormality of the fingertips (HP:0001211)0.63248068
152Congenital hepatic fibrosis (HP:0002612)0.63143551
153Anophthalmia (HP:0000528)0.63078658
154Aqueductal stenosis (HP:0002410)0.60064738
155Depression (HP:0000716)0.59527468
156Postaxial hand polydactyly (HP:0001162)0.58694724
157Hypoventilation (HP:0002791)0.58331275
158Abnormality of cells of the lymphoid lineage (HP:0012140)0.58145584
159Hypodontia (HP:0000668)0.57407713
160Generalized myoclonic seizures (HP:0002123)0.57056067
161Insomnia (HP:0100785)0.56840020
162Dental crowding (HP:0000678)0.55590723
163Intention tremor (HP:0002080)0.55244898
164Broad-based gait (HP:0002136)0.54217214
165Short foot (HP:0001773)0.54145260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.97721570
2ADRBK23.68617454
3PINK13.13962921
4IRAK23.04187538
5BMPR1B3.00782944
6MAP4K22.99573838
7MAP3K102.76363556
8ZAK2.46083562
9NUAK12.18287876
10ACVR1B2.12671862
11TLK12.00795118
12GRK111.4600407
13WNK31.96821153
14SIK21.91555304
15CAMK1G1.64980812
16OXSR11.61456530
17STK391.57271286
18BCKDK1.56048035
19DAPK21.53530717
20MAPK131.51699611
21TXK1.51048720
22CASK1.48387742
23CDK121.44829909
24HIPK21.43772081
25PAK61.39849907
26SGK4941.35013177
27SGK2231.35013177
28ICK1.33998047
29CAMK1D1.33925557
30ADRBK11.32246573
31BRD41.28135274
32ERBB21.27298355
33PNCK1.23112273
34MARK11.21056615
35CAMKK21.20699896
36PRKD31.19510425
37MAPK71.19011405
38PRKCH1.18428787
39TIE11.18071946
40TEC1.17445934
41MAPK121.14358062
42MAP3K41.12621213
43NEK11.12141214
44TRIM281.09961327
45CSNK1D1.09289996
46PRKCE1.06786725
47STK381.06073539
48TGFBR11.05776856
49INSRR1.05599900
50PTK2B1.05449020
51MAP2K61.02152775
52TAOK31.02072769
53MKNK21.01757810
54TNK20.96741812
55MAPKAPK30.95608519
56SCYL20.94707964
57PRKCZ0.93340361
58WNK10.93025171
59RPS6KA40.92921113
60FLT30.88903712
61DYRK20.87681126
62CAMKK10.84824409
63SGK20.84470254
64SGK30.82824658
65FGFR20.82809610
66GRK50.79655507
67IKBKB0.78683602
68DYRK1B0.77840732
69TNIK0.76434644
70DYRK1A0.75957127
71PRKCB0.74829531
72EIF2AK30.71683525
73ITK0.71523156
74BRSK20.71437226
75MAPK150.71129196
76PRKAA10.71041803
77VRK10.71028815
78LATS10.70410094
79MST40.67900507
80MAPKAPK50.67415335
81NEK20.65574990
82KIT0.64912624
83SIK10.64401384
84PLK20.63991397
85STK30.63774005
86STK38L0.62314588
87FER0.62249681
88GRK70.62245061
89RPS6KA30.60923970
90PRKACG0.60870515
91MKNK10.60511056
92PRKCQ0.59971375
93IRAK10.58269296
94CAMK2D0.56361835
95SGK10.55351798
96PRKD20.54869849
97RPS6KA50.54611202
98AKT30.53136449
99TRPM70.53124159
100CDK50.52642895
101MUSK0.52046890
102CSNK1G20.51525283
103CDK90.51248459
104FES0.51079063
105PRKAA20.49484753
106CSNK1G30.49112742
107CDK30.48890057
108GSK3B0.48762985
109STK110.48627000
110PRKDC0.48023472
111ALK0.47945775
112CSNK1G10.47923864
113SYK0.47489029
114PLK30.46626541
115OBSCN0.46573400
116MAPK140.46350681
117MINK10.45549871
118MAPK100.45479997
119ERBB30.45110960
120PLK40.44917566
121MAPK90.44663092
122PRKCI0.43279346
123PIK3CA0.43121519
124CAMK10.42977075
125CHUK0.41830608
126PIK3CG0.41242185
127CAMK40.40192325
128EPHA30.40175211
129FRK0.38938822
130IGF1R0.38655547
131CDK10.38491985
132CAMK2A0.38439569
133CCNB10.37914993
134MAP3K70.37841285
135NTRK20.37761010
136TTK0.37690371
137CSNK1A10.37449511
138NTRK30.37302563
139ABL10.36621060
140MAP2K40.36290409
141WNK40.36087405
142AKT20.35916851
143CDC42BPA0.35738873
144STK160.35695886
145CDK80.35305035
146PHKG10.34949377
147PHKG20.34949377
148PRKG10.33353387
149MAP2K10.33114352
150PRKCG0.32791685
151NEK60.31918023
152PKN10.31744185
153CSNK1E0.31480434
154RIPK10.31409503
155LYN0.30753293
156MAP2K70.30461468
157PRKD10.29978408
158PRKACA0.29110743
159MAP3K90.28656646
160RET0.26322370
161PRKCA0.25903718
162MAPK80.25573039
163FYN0.25252682
164PAK30.23319356
165ATM0.22426843
166PRPF4B0.22372244
167CSNK1A1L0.21785207
168PDGFRB0.21744963

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52824919
2Butanoate metabolism_Homo sapiens_hsa006502.46201651
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31417558
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20883551
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15383395
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12466710
7Ether lipid metabolism_Homo sapiens_hsa005652.07816721
8Tryptophan metabolism_Homo sapiens_hsa003802.01366134
9Homologous recombination_Homo sapiens_hsa034402.00726748
10Phototransduction_Homo sapiens_hsa0474415.6545783
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95861606
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93537804
13Synaptic vesicle cycle_Homo sapiens_hsa047211.75478729
14RNA polymerase_Homo sapiens_hsa030201.71102526
15Oxidative phosphorylation_Homo sapiens_hsa001901.66204826
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58709910
17Propanoate metabolism_Homo sapiens_hsa006401.55404278
18Olfactory transduction_Homo sapiens_hsa047401.54322450
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.51416893
20Basal transcription factors_Homo sapiens_hsa030221.46627288
21Fanconi anemia pathway_Homo sapiens_hsa034601.45435493
22Arachidonic acid metabolism_Homo sapiens_hsa005901.43829051
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40389057
24Taste transduction_Homo sapiens_hsa047421.35132715
25Selenocompound metabolism_Homo sapiens_hsa004501.33071846
26GABAergic synapse_Homo sapiens_hsa047271.31941438
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.31691877
28Nitrogen metabolism_Homo sapiens_hsa009101.31243683
29Protein export_Homo sapiens_hsa030601.27209913
30One carbon pool by folate_Homo sapiens_hsa006701.24855761
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.21392818
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17931936
33Chemical carcinogenesis_Homo sapiens_hsa052041.17095110
34Asthma_Homo sapiens_hsa053101.16782779
35Regulation of autophagy_Homo sapiens_hsa041401.15638467
36Parkinsons disease_Homo sapiens_hsa050121.11671321
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11353336
38beta-Alanine metabolism_Homo sapiens_hsa004101.04203075
39Peroxisome_Homo sapiens_hsa041461.00978453
40Cholinergic synapse_Homo sapiens_hsa047250.99462340
41Ovarian steroidogenesis_Homo sapiens_hsa049130.95971004
42Type I diabetes mellitus_Homo sapiens_hsa049400.95301795
43RNA degradation_Homo sapiens_hsa030180.91664534
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91487703
45Circadian entrainment_Homo sapiens_hsa047130.89608902
46Glutamatergic synapse_Homo sapiens_hsa047240.89583753
47Sulfur metabolism_Homo sapiens_hsa009200.88157053
48Graft-versus-host disease_Homo sapiens_hsa053320.87809753
49Retinol metabolism_Homo sapiens_hsa008300.87204252
50Morphine addiction_Homo sapiens_hsa050320.85841644
51Huntingtons disease_Homo sapiens_hsa050160.84185892
52Dopaminergic synapse_Homo sapiens_hsa047280.82950415
53Circadian rhythm_Homo sapiens_hsa047100.81112466
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78163830
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77528779
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76085503
57Fatty acid degradation_Homo sapiens_hsa000710.74213245
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74115564
59Allograft rejection_Homo sapiens_hsa053300.73571918
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72744823
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71138394
62Dorso-ventral axis formation_Homo sapiens_hsa043200.70618589
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70436463
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69455902
65Alzheimers disease_Homo sapiens_hsa050100.67762655
66Sulfur relay system_Homo sapiens_hsa041220.67589265
67ABC transporters_Homo sapiens_hsa020100.67228433
68Autoimmune thyroid disease_Homo sapiens_hsa053200.66597978
69Histidine metabolism_Homo sapiens_hsa003400.66481254
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63702561
71Primary immunodeficiency_Homo sapiens_hsa053400.63034194
72Serotonergic synapse_Homo sapiens_hsa047260.61936147
73Metabolic pathways_Homo sapiens_hsa011000.61063368
74Insulin secretion_Homo sapiens_hsa049110.60492890
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57835236
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57311667
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56784227
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54777178
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53135196
80Nicotine addiction_Homo sapiens_hsa050330.52422400
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51533875
82Sphingolipid metabolism_Homo sapiens_hsa006000.49644065
83Oxytocin signaling pathway_Homo sapiens_hsa049210.48150335
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46772972
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46666320
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46402074
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46167750
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46078025
89Fatty acid metabolism_Homo sapiens_hsa012120.45978462
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45890179
91Pyrimidine metabolism_Homo sapiens_hsa002400.45889764
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.43696640
93mTOR signaling pathway_Homo sapiens_hsa041500.43575976
94Vitamin digestion and absorption_Homo sapiens_hsa049770.43433525
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42373187
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39640113
97cAMP signaling pathway_Homo sapiens_hsa040240.39384292
98Inositol phosphate metabolism_Homo sapiens_hsa005620.39187694
99Non-homologous end-joining_Homo sapiens_hsa034500.38822237
100Fructose and mannose metabolism_Homo sapiens_hsa000510.35843029
101Renin secretion_Homo sapiens_hsa049240.35433357
102Salivary secretion_Homo sapiens_hsa049700.35394830
103Arginine biosynthesis_Homo sapiens_hsa002200.34923957
104Dilated cardiomyopathy_Homo sapiens_hsa054140.34866486
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33586293
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.33059729
107Gastric acid secretion_Homo sapiens_hsa049710.32879087
108Lysine degradation_Homo sapiens_hsa003100.32407060
109Cocaine addiction_Homo sapiens_hsa050300.32165231
110Rheumatoid arthritis_Homo sapiens_hsa053230.31765726
111Arginine and proline metabolism_Homo sapiens_hsa003300.31354518
112Cardiac muscle contraction_Homo sapiens_hsa042600.31314263
113Glycerolipid metabolism_Homo sapiens_hsa005610.30828656
114Type II diabetes mellitus_Homo sapiens_hsa049300.30293509
115Long-term potentiation_Homo sapiens_hsa047200.30075616
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27217397
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.27016538
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26845583
119Purine metabolism_Homo sapiens_hsa002300.26590204
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25029863
121Glucagon signaling pathway_Homo sapiens_hsa049220.24270440
122Amphetamine addiction_Homo sapiens_hsa050310.24061558
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.22831514
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22425854
125HIF-1 signaling pathway_Homo sapiens_hsa040660.22321123
126Alcoholism_Homo sapiens_hsa050340.22251874
127Bile secretion_Homo sapiens_hsa049760.22237771
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21793629
129Chemokine signaling pathway_Homo sapiens_hsa040620.21406888
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.21336821
131AMPK signaling pathway_Homo sapiens_hsa041520.21114950
132Fatty acid elongation_Homo sapiens_hsa000620.20498450
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20235808
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17845011
135GnRH signaling pathway_Homo sapiens_hsa049120.17566532
136Tight junction_Homo sapiens_hsa045300.16294198
137Biosynthesis of amino acids_Homo sapiens_hsa012300.16229945
138Ras signaling pathway_Homo sapiens_hsa040140.15970521
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.15210580
140mRNA surveillance pathway_Homo sapiens_hsa030150.14719020
141Thyroid hormone synthesis_Homo sapiens_hsa049180.14712827
142Pancreatic secretion_Homo sapiens_hsa049720.14308843
143Glioma_Homo sapiens_hsa052140.14266377
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.13650347
145Galactose metabolism_Homo sapiens_hsa000520.12148895
146Caffeine metabolism_Homo sapiens_hsa002320.12136732
147Calcium signaling pathway_Homo sapiens_hsa040200.11950595
148Insulin resistance_Homo sapiens_hsa049310.11574564
149MAPK signaling pathway_Homo sapiens_hsa040100.11158715
150Choline metabolism in cancer_Homo sapiens_hsa052310.10670450
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10493075
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.09876687
153Renal cell carcinoma_Homo sapiens_hsa052110.09835284
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09196239
155Fatty acid biosynthesis_Homo sapiens_hsa000610.08517205
156Hippo signaling pathway_Homo sapiens_hsa043900.08469951
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07310111
158Fat digestion and absorption_Homo sapiens_hsa049750.06808567
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06657867
160Mineral absorption_Homo sapiens_hsa049780.06416801
161ErbB signaling pathway_Homo sapiens_hsa040120.06296521
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06236669
163Wnt signaling pathway_Homo sapiens_hsa043100.05825929
164Melanogenesis_Homo sapiens_hsa049160.05504705
165Collecting duct acid secretion_Homo sapiens_hsa049660.05467423
166Linoleic acid metabolism_Homo sapiens_hsa005910.05033618
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.04212807
168Endocytosis_Homo sapiens_hsa041440.04107974

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