ROPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.80631923
2melanin metabolic process (GO:0006582)9.73099077
3axonemal dynein complex assembly (GO:0070286)9.69339738
4motile cilium assembly (GO:0044458)9.57722507
5spermatid development (GO:0007286)9.42036860
6secondary metabolite biosynthetic process (GO:0044550)9.07448888
7cilium movement (GO:0003341)8.07260557
8response to pheromone (GO:0019236)7.96419725
9single fertilization (GO:0007338)7.58445237
10regulation of cilium movement (GO:0003352)7.56476680
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.40384332
12sperm capacitation (GO:0048240)7.16908443
13male meiosis (GO:0007140)6.93267835
14synaptonemal complex organization (GO:0070193)6.88276609
15synaptonemal complex assembly (GO:0007130)6.81239896
16spermatid nucleus differentiation (GO:0007289)6.51870442
17piRNA metabolic process (GO:0034587)6.49500741
18spermatogenesis (GO:0007283)6.25776409
19fertilization (GO:0009566)6.25759568
20male gamete generation (GO:0048232)6.23418082
21organic cation transport (GO:0015695)6.19380839
22negative regulation of inclusion body assembly (GO:0090084)6.13188671
23microtubule depolymerization (GO:0007019)6.08741289
24gamete generation (GO:0007276)5.73583376
25calcium ion-dependent exocytosis (GO:0017156)5.60391132
26regulation of inclusion body assembly (GO:0090083)5.31177349
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.30495830
28germ cell development (GO:0007281)5.22959871
29cell recognition (GO:0008037)5.20552056
30sexual reproduction (GO:0019953)5.07296572
31ventricular system development (GO:0021591)5.01270308
32ketone body metabolic process (GO:1902224)4.86495083
33melanocyte differentiation (GO:0030318)4.83182543
34pigment cell differentiation (GO:0050931)4.78039760
35tyrosine metabolic process (GO:0006570)4.76550652
36single strand break repair (GO:0000012)4.68708631
37glycerol ether metabolic process (GO:0006662)4.65635291
38chromosome organization involved in meiosis (GO:0070192)4.63552450
39microtubule severing (GO:0051013)4.53613344
40multicellular organismal reproductive process (GO:0048609)4.50657900
41chromosome condensation (GO:0030261)4.43109354
42regulation of microtubule-based movement (GO:0060632)4.42643989
43ether metabolic process (GO:0018904)4.30353385
44male meiosis I (GO:0007141)4.29266247
45DNA methylation involved in gamete generation (GO:0043046)4.26631777
46DNA packaging (GO:0006323)4.20888902
47melanosome organization (GO:0032438)4.17538174
48meiotic nuclear division (GO:0007126)4.16074972
49seminiferous tubule development (GO:0072520)4.11919351
50endosome to melanosome transport (GO:0035646)4.02014330
51endosome to pigment granule transport (GO:0043485)4.02014330
52phenol-containing compound biosynthetic process (GO:0046189)3.98008060
53protein K11-linked deubiquitination (GO:0035871)3.95484555
54pigment granule organization (GO:0048753)3.87921521
55regulation of Rab GTPase activity (GO:0032313)3.87731737
56positive regulation of Rab GTPase activity (GO:0032851)3.87731737
57monoubiquitinated protein deubiquitination (GO:0035520)3.84742673
58left/right pattern formation (GO:0060972)3.82584642
59synaptic transmission, dopaminergic (GO:0001963)3.74974339
60regulation of p38MAPK cascade (GO:1900744)3.73385569
61chaperone-mediated protein complex assembly (GO:0051131)3.71677245
62coenzyme catabolic process (GO:0009109)3.68752189
63sequestering of actin monomers (GO:0042989)3.68682373
64cellular ketone body metabolic process (GO:0046950)3.65453892
65developmental pigmentation (GO:0048066)3.63708851
66multicellular organismal development (GO:0007275)3.60579724
67phosphatidylethanolamine biosynthetic process (GO:0006646)3.58518539
68genitalia morphogenesis (GO:0035112)3.47216450
69establishment of protein localization to Golgi (GO:0072600)3.46282583
70meiosis I (GO:0007127)3.39879963
71phosphatidylethanolamine metabolic process (GO:0046337)3.38580613
72protein targeting to Golgi (GO:0000042)3.36673866
73rRNA methylation (GO:0031167)3.35082001
74positive regulation of macrophage activation (GO:0043032)3.23781499
75microtubule polymerization or depolymerization (GO:0031109)3.21864401
76protein polyglutamylation (GO:0018095)3.19945023
77centriole assembly (GO:0098534)3.17936689
78pigmentation (GO:0043473)3.16493308
79carnitine transport (GO:0015879)3.11720804
80amino-acid betaine transport (GO:0015838)3.11720804
81nucleus organization (GO:0006997)3.10708248
82neuroepithelial cell differentiation (GO:0060563)3.08578147
83meiotic cell cycle (GO:0051321)3.06008789
84protein localization to cilium (GO:0061512)3.03120821
85protein refolding (GO:0042026)2.99502325
86peristalsis (GO:0030432)2.99066933
87retrograde transport, vesicle recycling within Golgi (GO:0000301)2.98681758
88carnitine transmembrane transport (GO:1902603)2.96449025
89regulation of spindle checkpoint (GO:0090231)2.93712330
90C4-dicarboxylate transport (GO:0015740)2.91712522
91polyol catabolic process (GO:0046174)2.91199466
92glycolytic process (GO:0006096)2.91055625
93enteric nervous system development (GO:0048484)2.90353239
94centriole replication (GO:0007099)2.89150483
95cilium organization (GO:0044782)2.87249539
96microtubule nucleation (GO:0007020)2.86690160
97response to acidic pH (GO:0010447)2.85486389
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84648523
99regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.83593623
100regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.83593623
101alditol metabolic process (GO:0019400)2.83504940
102signal peptide processing (GO:0006465)2.83178053
103centrosome duplication (GO:0051298)2.81342878
104cornea development in camera-type eye (GO:0061303)2.81053706
105cilium assembly (GO:0042384)2.76971380
106phasic smooth muscle contraction (GO:0014821)2.75494921
107cellular component assembly involved in morphogenesis (GO:0010927)2.74427715
108pigment biosynthetic process (GO:0046148)2.74133107
109microtubule-based movement (GO:0007018)2.74114527
110detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.72705191
111interferon-gamma secretion (GO:0072643)2.71905912
112nucleoside diphosphate phosphorylation (GO:0006165)2.71552951
113rRNA modification (GO:0000154)2.69886297
114negative regulation of organelle assembly (GO:1902116)2.68863651
115intraciliary transport (GO:0042073)2.67394119
116negative regulation of transcription by competitive promoter binding (GO:0010944)2.67243016
117axoneme assembly (GO:0035082)2.65890717
118lactate metabolic process (GO:0006089)2.63740949
119cilium morphogenesis (GO:0060271)2.63565604
120synapsis (GO:0007129)2.61688039
121chromatin silencing (GO:0006342)2.60975686
122protein-DNA complex disassembly (GO:0032986)2.60718694
123nucleosome disassembly (GO:0006337)2.60718694
124meiotic cell cycle process (GO:1903046)2.59455444
125negative regulation of Rho protein signal transduction (GO:0035024)2.55902353
126positive regulation of neuroblast proliferation (GO:0002052)2.55667135
127peripheral nervous system development (GO:0007422)2.55516436
128regulation of endothelial cell differentiation (GO:0045601)2.54413999
129response to methylmercury (GO:0051597)2.53360860
130RNA localization (GO:0006403)2.50213928
131polyamine biosynthetic process (GO:0006596)2.50162573
132glycerol metabolic process (GO:0006071)2.49997654
133mitotic sister chromatid cohesion (GO:0007064)2.49353689
134dendritic spine organization (GO:0097061)2.48458424
135peptidyl-threonine dephosphorylation (GO:0035970)2.46990042
136GTP biosynthetic process (GO:0006183)2.46279072
137behavioral response to cocaine (GO:0048148)2.45603474
138regulation of cytokine production involved in inflammatory response (GO:1900015)2.42972331
139cell wall macromolecule catabolic process (GO:0016998)16.4091038
140cell wall macromolecule metabolic process (GO:0044036)16.4091038
141fusion of sperm to egg plasma membrane (GO:0007342)14.4995797
142sperm motility (GO:0030317)13.1373218
143acrosome assembly (GO:0001675)11.8981566
144sperm-egg recognition (GO:0035036)11.8952691
145multicellular organism reproduction (GO:0032504)11.7079943
146acrosome reaction (GO:0007340)11.5049262
147plasma membrane fusion (GO:0045026)11.0716557
148melanin biosynthetic process (GO:0042438)10.8283792
149cell-cell recognition (GO:0009988)10.6682685
150binding of sperm to zona pellucida (GO:0007339)10.5604664
151reproduction (GO:0000003)10.2335435
152epithelial cilium movement (GO:0003351)10.0115840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.73026840
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.82871911
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.66572136
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39931479
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19083425
6EZH2_22144423_ChIP-Seq_EOC_Human3.17751967
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09623247
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84288364
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59036875
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.37276417
11FUS_26573619_Chip-Seq_HEK293_Human2.32961257
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27770267
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21566076
14* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18131798
15AR_21572438_ChIP-Seq_LNCaP_Human2.13688315
16ER_23166858_ChIP-Seq_MCF-7_Human2.12159201
17VDR_22108803_ChIP-Seq_LS180_Human2.09092519
18* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.06740828
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06064848
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01938371
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.00769802
22P300_19829295_ChIP-Seq_ESCs_Human1.99868825
23ZNF274_21170338_ChIP-Seq_K562_Hela1.95425900
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.95278892
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.91111318
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88382555
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.87681750
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.82453947
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.79915332
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.77553969
31SMAD4_21741376_ChIP-Seq_EPCs_Human1.76433754
32AR_25329375_ChIP-Seq_VCAP_Human1.75260380
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73123488
34STAT1_17558387_ChIP-Seq_HELA_Human1.72658454
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.72298521
36KDM2B_26808549_Chip-Seq_REH_Human1.70978151
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70552273
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.69831617
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69544360
40TAL1_26923725_Chip-Seq_HPCs_Mouse1.65468424
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64329935
42RBPJ_21746931_ChIP-Seq_IB4_Human1.64080883
43STAT3_23295773_ChIP-Seq_U87_Human1.61881474
44SMAD4_21799915_ChIP-Seq_A2780_Human1.60655169
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.60382577
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.60329446
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59646197
48GBX2_23144817_ChIP-Seq_PC3_Human1.58191533
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.56590573
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.56214071
51CBX2_22325352_ChIP-Seq_293T-Rex_Human1.55651078
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.54982420
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.54483167
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53999098
55FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53072015
56HNFA_21074721_ChIP-Seq_CACO-2_Human1.52365782
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52137936
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.51603490
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50347678
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50095883
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49016748
62* TCF4_23295773_ChIP-Seq_U87_Human1.48981532
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48757534
64GATA6_21074721_ChIP-Seq_CACO-2_Human1.48617770
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48607583
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48149159
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.47666447
68TBL1_22424771_ChIP-Seq_293T_Human1.47090925
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47066168
70CBP_20019798_ChIP-Seq_JUKART_Human1.47066168
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.45931665
72PHF8_20622853_ChIP-Seq_HELA_Human1.45889375
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.44462363
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41467784
75ETV1_20927104_ChIP-Seq_GIST48_Human1.41054666
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.40569461
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40074794
78HOXB7_26014856_ChIP-Seq_BT474_Human1.39826450
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.38519799
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.38514293
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38506844
82NANOG_20526341_ChIP-Seq_ESCs_Human1.37364359
83MYC_19829295_ChIP-Seq_ESCs_Human1.36984116
84NFYA_21822215_ChIP-Seq_K562_Human1.36953872
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.36008988
86RAC3_21632823_ChIP-Seq_H3396_Human1.35937148
87ERA_21632823_ChIP-Seq_H3396_Human1.34322484
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.32376973
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31538244
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31113076
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.30461293
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.29946380
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29753600
94* NANOG_19829295_ChIP-Seq_ESCs_Human1.28935912
95* SOX2_19829295_ChIP-Seq_ESCs_Human1.28935912
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.28494105
97CJUN_26792858_Chip-Seq_BT549_Human1.26832346
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25296996
99TP53_18474530_ChIP-ChIP_U2OS_Human1.24969398
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24466263
101* REST_21632747_ChIP-Seq_MESCs_Mouse1.24166209
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22892095
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22538696
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.22213506
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.21419293
106* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20355772
107FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20323291
108GF1_26923725_Chip-Seq_HPCs_Mouse1.19549714
109P53_22387025_ChIP-Seq_ESCs_Mouse1.19523127
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19121019
111TCF4_22108803_ChIP-Seq_LS180_Human1.18722512
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17791243
113* P53_21459846_ChIP-Seq_SAOS-2_Human1.17434193
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17343854
115CDX2_22108803_ChIP-Seq_LS180_Human1.17126635
116DROSHA_22980978_ChIP-Seq_HELA_Human1.15109109
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15097135
118MITF_21258399_ChIP-Seq_MELANOMA_Human1.13938644
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13759278
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13746118
121P300_18555785_Chip-Seq_ESCs_Mouse1.13087736
122CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12313314
123RXR_22108803_ChIP-Seq_LS180_Human1.12029402
124RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11983549
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11157096
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10907342
127TAF2_19829295_ChIP-Seq_ESCs_Human1.10793738
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.10793313
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10683008
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10581077
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10581077
132AHR_22903824_ChIP-Seq_MCF-7_Human1.09880492
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09706619
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09451857
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08268098
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08200809
137OCT1_27270436_Chip-Seq_PROSTATE_Human1.07180097
138ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06548102
139* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06445130
140SPI1_26923725_Chip-Seq_HPCs_Mouse1.06326139
141EZH2_27294783_Chip-Seq_NPCs_Mouse1.06010099
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05976040
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05663618
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05459765
145ESET_19884257_ChIP-Seq_ESCs_Mouse1.05223856
146SOX9_26525672_Chip-Seq_HEART_Mouse1.05078074
147RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05068734
148SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04506848
149PIAS1_25552417_ChIP-Seq_VCAP_Human1.04439709
150FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03719232
151FOXA1_25329375_ChIP-Seq_VCAP_Human1.03719232
152TAF15_26573619_Chip-Seq_HEK293_Human1.02289277
153SOX2_18555785_Chip-Seq_ESCs_Mouse1.00825744
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00503047
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00459924
156* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99493057
157STAT3_18555785_Chip-Seq_ESCs_Mouse0.99082114
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98492950
159* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98106456
160PU1_27457419_Chip-Seq_LIVER_Mouse0.97278564
161SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96998547
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96210187
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.96059905
164CTCF_18555785_Chip-Seq_ESCs_Mouse0.95165546
165GF1B_26923725_Chip-Seq_HPCs_Mouse0.95164442
166PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93549758
167ERG_20517297_ChIP-Seq_VCAP_Human0.93087563
168FLI1_21867929_ChIP-Seq_CD8_Mouse0.92453151
169RNF2_27304074_Chip-Seq_NSC_Mouse0.91849669
170E2F1_18555785_Chip-Seq_ESCs_Mouse0.91568589
171* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91539350
172NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.91142246
173NFYB_21822215_ChIP-Seq_K562_Human0.89807310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.24187856
2MP0005408_hypopigmentation6.34846835
3MP0003698_abnormal_male_reproductive6.13895474
4MP0000372_irregular_coat_pigmentation5.78165696
5MP0001929_abnormal_gametogenesis5.58119051
6MP0003136_yellow_coat_color4.88896204
7MP0000015_abnormal_ear_pigmentation4.54173095
8MP0005075_abnormal_melanosome_morpholog4.36911352
9MP0008877_abnormal_DNA_methylation4.07841179
10MP0002095_abnormal_skin_pigmentation3.87806099
11MP0004381_abnormal_hair_follicle3.65580342
12MP0002210_abnormal_sex_determination3.44896952
13MP0005174_abnormal_tail_pigmentation3.41379506
14MP0002161_abnormal_fertility/fecundity3.31866571
15MP0001145_abnormal_male_reproductive2.96035391
16MP0000371_diluted_coat_color2.75624884
17MP0005670_abnormal_white_adipose2.63033883
18MP0000653_abnormal_sex_gland2.58195855
19MP0002653_abnormal_ependyma_morphology2.57487647
20MP0005451_abnormal_body_composition2.50688030
21MP0005257_abnormal_intraocular_pressure2.11188370
22MP0002938_white_spotting2.08480622
23MP0002075_abnormal_coat/hair_pigmentati2.04513296
24MP0005410_abnormal_fertilization16.3890769
25MP0004233_abnormal_muscle_weight1.88223626
26MP0002877_abnormal_melanocyte_morpholog1.78638812
27MP0001186_pigmentation_phenotype1.76706969
28MP0002160_abnormal_reproductive_system1.75255323
29MP0005248_abnormal_Harderian_gland1.74893347
30MP0005623_abnormal_meninges_morphology1.49837282
31MP0003646_muscle_fatigue1.46444313
32MP0003718_maternal_effect1.42869081
33MP0002822_catalepsy1.42586608
34MP0001881_abnormal_mammary_gland1.31365662
35MP0000427_abnormal_hair_cycle1.29186748
36MP0002282_abnormal_trachea_morphology1.18016947
37MP0001348_abnormal_lacrimal_gland1.16811517
38MP0001765_abnormal_ion_homeostasis1.16209835
39MP0001984_abnormal_olfaction1.08636345
40MP0009046_muscle_twitch1.06577219
41MP0001485_abnormal_pinna_reflex1.05737684
42MP0008058_abnormal_DNA_repair1.01962867
43MP0002234_abnormal_pharynx_morphology0.96249491
44MP0005423_abnormal_somatic_nervous0.92462955
45MP0005197_abnormal_uvea_morphology0.91192389
46MP0005647_abnormal_sex_gland0.91046347
47MP0005389_reproductive_system_phenotype0.87008365
48MP0002102_abnormal_ear_morphology0.85781323
49MP0000579_abnormal_nail_morphology0.77879138
50MP0001905_abnormal_dopamine_level0.65407340
51MP0003172_abnormal_lysosome_physiology0.65228047
52MP0001963_abnormal_hearing_physiology0.64786797
53MP0002098_abnormal_vibrissa_morphology0.64247004
54MP0005636_abnormal_mineral_homeostasis0.64182115
55MP0003115_abnormal_respiratory_system0.63927949
56MP0000367_abnormal_coat/_hair0.62676479
57MP0002638_abnormal_pupillary_reflex0.61025023
58MP0002090_abnormal_vision0.60358348
59MP0000383_abnormal_hair_follicle0.59393799
60MP0000647_abnormal_sebaceous_gland0.59026736
61MP0008995_early_reproductive_senescence0.58010490
62MP0005379_endocrine/exocrine_gland_phen0.57633704
63MP0002928_abnormal_bile_duct0.56238656
64MP0009697_abnormal_copulation0.55774610
65MP0005395_other_phenotype0.55416602
66MP0003806_abnormal_nucleotide_metabolis0.54676238
67MP0002177_abnormal_outer_ear0.54384420
68MP0000678_abnormal_parathyroid_gland0.53951071
69MP0002269_muscular_atrophy0.53856316
70MP0003011_delayed_dark_adaptation0.53742409
71MP0010094_abnormal_chromosome_stability0.53058367
72MP0001324_abnormal_eye_pigmentation0.52354656
73MP0000026_abnormal_inner_ear0.52233877
74MP0006036_abnormal_mitochondrial_physio0.52096034
75MP0004885_abnormal_endolymph0.51421661
76MP0004036_abnormal_muscle_relaxation0.51019524
77MP0000358_abnormal_cell_content/0.49940168
78MP0003878_abnormal_ear_physiology0.49037226
79MP0005377_hearing/vestibular/ear_phenot0.49037226
80MP0005551_abnormal_eye_electrophysiolog0.48400131
81MP0000377_abnormal_hair_follicle0.48274363
82MP0002909_abnormal_adrenal_gland0.47867624
83MP0005666_abnormal_adipose_tissue0.47598838
84MP0003699_abnormal_female_reproductive0.47312105
85MP0004147_increased_porphyrin_level0.45248004
86MP0001486_abnormal_startle_reflex0.44865826
87MP0002272_abnormal_nervous_system0.44737342
88MP0006276_abnormal_autonomic_nervous0.44644536
89MP0003950_abnormal_plasma_membrane0.44372226
90MP0001501_abnormal_sleep_pattern0.43250493
91MP0002067_abnormal_sensory_capabilities0.41739302
92MP0005409_darkened_coat_color0.41718667
93MP0001293_anophthalmia0.41597347
94MP0001764_abnormal_homeostasis0.40610229
95MP0000627_abnormal_mammary_gland0.40370599
96MP0002735_abnormal_chemical_nociception0.40198608
97MP0003329_amyloid_beta_deposits0.40175049
98MP0002971_abnormal_brown_adipose0.40172744
99MP0008770_decreased_survivor_rate0.40158597
100MP0002139_abnormal_hepatobiliary_system0.39867940
101MP0009745_abnormal_behavioral_response0.39607804
102MP0002736_abnormal_nociception_after0.39055974
103MP0010678_abnormal_skin_adnexa0.37812735
104MP0004019_abnormal_vitamin_homeostasis0.37436499
105MP0003633_abnormal_nervous_system0.37276764
106MP0009115_abnormal_fat_cell0.36787799
107MP0005253_abnormal_eye_physiology0.36683249
108MP0006035_abnormal_mitochondrial_morpho0.36440828
109MP0000749_muscle_degeneration0.35766528
110MP0003936_abnormal_reproductive_system0.35502505
111MP0003880_abnormal_central_pattern0.35256854
112MP0009053_abnormal_anal_canal0.34692913
113MP0000639_abnormal_adrenal_gland0.34656932
114MP0000920_abnormal_myelination0.33138115
115MP0001119_abnormal_female_reproductive0.32287181
116MP0002572_abnormal_emotion/affect_behav0.31580020
117MP0004484_altered_response_of0.31258618
118MP0004811_abnormal_neuron_physiology0.30801845
119MP0004133_heterotaxia0.29264118
120MP0002132_abnormal_respiratory_system0.27398133
121MP0010307_abnormal_tumor_latency0.26941633
122MP0001968_abnormal_touch/_nociception0.26544192
123MP0005646_abnormal_pituitary_gland0.26496066
124MP0005391_vision/eye_phenotype0.26145249
125MP0003632_abnormal_nervous_system0.25724378
126MP0003631_nervous_system_phenotype0.25314113
127MP0003111_abnormal_nucleus_morphology0.23987697
128MP0000534_abnormal_ureter_morphology0.23942190
129MP0002152_abnormal_brain_morphology0.23600126
130MP0005397_hematopoietic_system_phenotyp0.23399988
131MP0001545_abnormal_hematopoietic_system0.23399988
132MP0003861_abnormal_nervous_system0.23336781
133MP0005319_abnormal_enzyme/_coenzyme0.22252933
134MP0001661_extended_life_span0.21201494
135MP0008875_abnormal_xenobiotic_pharmacok0.21063040
136MP0005365_abnormal_bile_salt0.20848749
137MP0000604_amyloidosis0.20301217
138MP0001730_embryonic_growth_arrest0.19383279
139MP0003942_abnormal_urinary_system0.19338226
140MP0004145_abnormal_muscle_electrophysio0.19038902
141MP0005535_abnormal_body_temperature0.19018207
142MP0002169_no_abnormal_phenotype0.18766777
143MP0002873_normal_phenotype0.18529058
144MP0003879_abnormal_hair_cell0.17647377
145MP0008569_lethality_at_weaning0.17438635
146MP0002229_neurodegeneration0.17336165
147MP0009278_abnormal_bone_marrow0.17309845
148MP0003948_abnormal_gas_homeostasis0.17293441
149MP0000313_abnormal_cell_death0.17184333
150MP0002084_abnormal_developmental_patter0.17107102
151MP0002693_abnormal_pancreas_physiology0.17106339
152MP0003959_abnormal_lean_body0.16785231
153MP0005195_abnormal_posterior_eye0.15727246
154MP0008057_abnormal_DNA_replication0.15382133
155MP0004742_abnormal_vestibular_system0.15317862
156MP0004270_analgesia0.15267479
157MP0002118_abnormal_lipid_homeostasis0.14976803
158MP0003786_premature_aging0.14171104
159MP0000569_abnormal_digit_pigmentation0.13507411
160MP0004130_abnormal_muscle_cell0.13091616
161MP0001849_ear_inflammation0.12625350
162MP0002752_abnormal_somatic_nervous0.12546876
163MP0004043_abnormal_pH_regulation0.12250070
164MP0001270_distended_abdomen0.12244693
165MP0000001_mammalian_phenotype0.11772707
166MP0004084_abnormal_cardiac_muscle0.11726156
167MP0002557_abnormal_social/conspecific_i0.11558392

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.31980155
2Abnormal respiratory motile cilium morphology (HP:0005938)9.31980155
3Abnormal respiratory motile cilium physiology (HP:0012261)9.25778012
4White forelock (HP:0002211)8.09465319
5Patchy hypopigmentation of hair (HP:0011365)7.75630426
6Rhinitis (HP:0012384)7.64613401
7Abnormal ciliary motility (HP:0012262)7.45615290
8Chronic bronchitis (HP:0004469)7.39303359
9Nasal polyposis (HP:0100582)6.40436486
10Infertility (HP:0000789)6.38464360
11Hypoplasia of the fovea (HP:0007750)6.32759995
12Aplasia/Hypoplasia of the fovea (HP:0008060)6.32759995
13Blue irides (HP:0000635)5.92191462
14Aplasia/Hypoplasia of the macula (HP:0008059)5.82085740
15Ocular albinism (HP:0001107)5.65308993
16Abnormality of the fovea (HP:0000493)5.44920932
17Aplasia/Hypoplasia affecting the retina (HP:0008061)5.39370174
18Congenital sensorineural hearing impairment (HP:0008527)5.26945300
19Abnormality of the nasal mucosa (HP:0000433)5.26426804
20Severe visual impairment (HP:0001141)5.07437729
21Iris hypopigmentation (HP:0007730)4.83300901
22Albinism (HP:0001022)4.76225030
23Bronchitis (HP:0012387)4.49165471
24Bronchiectasis (HP:0002110)4.46979067
25Generalized hypopigmentation (HP:0007513)4.41432323
26Abnormal auditory evoked potentials (HP:0006958)4.34409541
27Hypopigmentation of the fundus (HP:0007894)4.18761792
28Male infertility (HP:0003251)4.12903735
29Nephronophthisis (HP:0000090)4.11974437
30Abnormality of macular pigmentation (HP:0008002)3.91693582
31Hypoplasia of the iris (HP:0007676)3.90911202
32Spastic paraparesis (HP:0002313)3.52624641
33Abnormal spermatogenesis (HP:0008669)3.45038352
34Premature graying of hair (HP:0002216)3.44685747
35Recurrent sinusitis (HP:0011108)3.41644705
36Heterochromia iridis (HP:0001100)3.40838669
37Adrenal hypoplasia (HP:0000835)3.39238190
38Cone-rod dystrophy (HP:0000548)3.24406580
39Attenuation of retinal blood vessels (HP:0007843)3.23140258
40Recurrent otitis media (HP:0000403)3.22194253
41Medial flaring of the eyebrow (HP:0010747)3.21455610
42Bony spicule pigmentary retinopathy (HP:0007737)3.20605064
43Absent epiphyses (HP:0010577)3.17276884
44Abnormality of the renal medulla (HP:0100957)3.11192514
45Cutaneous melanoma (HP:0012056)2.98301062
46Peripheral hypomyelination (HP:0007182)2.89083902
47Tubulointerstitial nephritis (HP:0001970)2.88559164
48Chronic hepatic failure (HP:0100626)2.84712353
49Flat capital femoral epiphysis (HP:0003370)2.77956249
50Cerebral hypomyelination (HP:0006808)2.77908884
51Abnormality of midbrain morphology (HP:0002418)2.66450700
52Molar tooth sign on MRI (HP:0002419)2.66450700
53Tubular atrophy (HP:0000092)2.59017765
54Congenital stationary night blindness (HP:0007642)2.56996567
55Recurrent bronchitis (HP:0002837)2.55740213
56Azoospermia (HP:0000027)2.50861242
57Abnormal rod and cone electroretinograms (HP:0008323)2.47466056
58Abnormality of the epiphysis of the femoral head (HP:0010574)2.42340525
59Hypoplastic ischia (HP:0003175)2.36410175
60Impulsivity (HP:0100710)2.36285522
61Pili torti (HP:0003777)2.35945720
62Tubulointerstitial abnormality (HP:0001969)2.34716017
63Generalized hypopigmentation of hair (HP:0011358)2.34524461
64Freckling (HP:0001480)2.30577674
65Abnormality of femoral epiphyses (HP:0006499)2.28060568
66Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.28060568
67Paraparesis (HP:0002385)2.26968749
68Underdeveloped nasal alae (HP:0000430)2.25394481
69Abnormality of the femoral head (HP:0003368)2.21935133
70Horizontal nystagmus (HP:0000666)2.21860832
71Gait imbalance (HP:0002141)2.17999792
72Congenital primary aphakia (HP:0007707)2.17649928
73Resting tremor (HP:0002322)2.13669325
74Lip pit (HP:0100267)2.12951389
75Photophobia (HP:0000613)2.09844723
76Cholecystitis (HP:0001082)2.05898087
77Abnormal gallbladder physiology (HP:0012438)2.05898087
78Morphological abnormality of the inner ear (HP:0011390)2.03912595
79Increased corneal curvature (HP:0100692)2.03832897
80Keratoconus (HP:0000563)2.03832897
81Gonadotropin excess (HP:0000837)2.01183365
82Astigmatism (HP:0000483)2.00004708
83Dynein arm defect of respiratory motile cilia (HP:0012255)13.2516377
84Absent/shortened dynein arms (HP:0200106)13.2516377
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1293455
86Hyperkalemia (HP:0002153)1.99881607
87Retinal dysplasia (HP:0007973)1.99173238
88Abnormality of the ischium (HP:0003174)1.96562568
89Large for gestational age (HP:0001520)1.91895074
90Abnormality of the nasal septum (HP:0000419)1.90887394
91Upper limb muscle weakness (HP:0003484)1.88685158
92Chronic sinusitis (HP:0011109)1.88121305
93Nephrogenic diabetes insipidus (HP:0009806)1.86493364
94Macular degeneration (HP:0000608)1.84527823
95Abnormality of the astrocytes (HP:0100707)1.83984573
96Astrocytoma (HP:0009592)1.83984573
97Dyschromatopsia (HP:0007641)1.81895436
98Atelectasis (HP:0100750)1.80739149
99Atonic seizures (HP:0010819)1.80246797
100Aplasia/Hypoplasia of the lens (HP:0008063)1.79843413
101Stage 5 chronic kidney disease (HP:0003774)1.79397768
102Tubulointerstitial fibrosis (HP:0005576)1.79384782
103Enlarged epiphyses (HP:0010580)1.79244889
104Postaxial foot polydactyly (HP:0001830)1.78636377
105Concave nail (HP:0001598)1.77758425
106Tongue fasciculations (HP:0001308)1.74894293
107Asymmetric septal hypertrophy (HP:0001670)1.74338484
108Type II lissencephaly (HP:0007260)1.72960623
109Heterotopia (HP:0002282)1.71398097
110Decreased central vision (HP:0007663)1.69890033
111Congenital hepatic fibrosis (HP:0002612)1.69041931
112Hand muscle atrophy (HP:0009130)1.68190597
113Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67070171
114Polydipsia (HP:0001959)1.66956187
115Abnormal drinking behavior (HP:0030082)1.66956187
116Potter facies (HP:0002009)1.66206881
117Facial shape deformation (HP:0011334)1.66206881
118Spastic tetraparesis (HP:0001285)1.65763923
119Abnormality of saccadic eye movements (HP:0000570)1.65068564
120Abnormality of renal excretion (HP:0011036)1.64445312
121Abnormality of the renal cortex (HP:0011035)1.64218016
122CNS hypomyelination (HP:0003429)1.63830275
123Poor coordination (HP:0002370)1.63549660
124Vaginal atresia (HP:0000148)1.63385814
125Muscle fibrillation (HP:0010546)1.61024784
126Genital tract atresia (HP:0001827)1.60817055
127Postaxial hand polydactyly (HP:0001162)1.60066438
128Pancreatic cysts (HP:0001737)1.58264315
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56725996
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.56505683
131Median cleft lip (HP:0000161)1.56494383
132Abnormality of the dental root (HP:0006486)1.55616910
133Taurodontia (HP:0000679)1.55616910
134Abnormality of permanent molar morphology (HP:0011071)1.55616910
135True hermaphroditism (HP:0010459)1.55248566
136Abnormal hair laboratory examination (HP:0003328)1.54874522
137Postural instability (HP:0002172)1.54735361
138Choroideremia (HP:0001139)1.54709676
139Oculomotor apraxia (HP:0000657)1.48855029
140Optic nerve hypoplasia (HP:0000609)1.48635055
141Bundle branch block (HP:0011710)1.48064446
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.47655972
143Abnormality of the neuromuscular junction (HP:0003398)1.46640614
144Fatigable weakness (HP:0003473)1.46640614
145Short ribs (HP:0000773)1.45779198
146Abnormal biliary tract physiology (HP:0012439)1.45295955
147Bile duct proliferation (HP:0001408)1.45295955
148Abnormality of molar (HP:0011077)1.44766330
149Abnormality of molar morphology (HP:0011070)1.44766330
150Abnormality of ocular smooth pursuit (HP:0000617)1.44555183
151Cerebellar dysplasia (HP:0007033)1.44017698
152Abnormality of the dental pulp (HP:0006479)1.43131488
153Renal dysplasia (HP:0000110)1.42932151
154Impaired smooth pursuit (HP:0007772)1.42081379
155Easy fatigability (HP:0003388)1.41951806
156Bell-shaped thorax (HP:0001591)1.40706765
157Double outlet right ventricle (HP:0001719)1.39329148
158Congenital malformation of the right heart (HP:0011723)1.39329148
159Facial cleft (HP:0002006)1.37345234
160Pancreatic fibrosis (HP:0100732)1.34650594
161Sensory axonal neuropathy (HP:0003390)1.34413491
162Hemorrhage of the eye (HP:0011885)1.30304456
163Cystic liver disease (HP:0006706)1.29893642
164Microglossia (HP:0000171)1.27798614
165Fibular hypoplasia (HP:0003038)1.26237947
166Type 2 muscle fiber atrophy (HP:0003554)1.26045640
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.25655850
168Abnormality of the lower motor neuron (HP:0002366)1.24867619
169Vascular calcification (HP:0004934)1.24865957
170Constricted visual fields (HP:0001133)1.24775734
171Abnormality of dentin (HP:0010299)1.24450122
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.24239453
173Abnormal urine output (HP:0012590)1.23964450
174Renovascular hypertension (HP:0100817)1.22606553
175Supernumerary spleens (HP:0009799)1.22446801
176Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.22410695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.07657154
2PDK49.07657154
3PDK25.89652416
4TESK15.52111240
5PRKD34.09055330
6FRK3.88475536
7DDR23.75000151
8ICK3.68848922
9PLK23.01448835
10TRIM282.78743487
11BMPR1B2.43700131
12INSRR2.27045512
13STK162.16837632
14FER2.06527877
15PTK2B2.03606753
16MST1R1.96165795
17SIK31.90646134
18CDK71.89914605
19MAP4K21.88629552
20WNK41.81032068
21STK391.77513049
22MAP3K31.63639766
23STK381.60543851
24BRD41.53400219
25ACVR1B1.51002423
26PNCK1.49005130
27NEK21.42036842
28PIK3CA1.30074178
29DYRK1B1.18231853
30PDK11.16899326
31TNIK1.10330507
32TAF11.07523336
33CDK191.05588561
34IRAK11.05422771
35PIK3CG1.04527787
36PRKAA21.01296497
37FGFR11.00272114
38CSNK1G20.97161710
39LMTK20.96793036
40CAMK1D0.88875353
41CSNK1A1L0.87243141
42CSNK1G10.86902245
43PAK30.85964814
44ERBB20.84363565
45CSNK1G30.80828715
46EIF2AK30.77203114
47EIF2AK10.75965189
48ERBB40.75601502
49NME20.75364782
50TYRO30.73990006
51MKNK10.73380164
52ERBB30.72108788
53BCR0.71551405
54PLK40.71245365
55NTRK30.68755073
56MAP2K10.68169553
57GRK10.67906967
58DYRK30.67490613
59PRKD10.63951408
60MET0.63904896
61PDPK10.63414430
62CHEK20.62435217
63IRAK20.62085324
64WNK10.61608530
65PASK0.59832959
66CCNB10.57684224
67MAP2K60.57178067
68MAPK150.55705720
69RIPK40.54828807
70STK30.53937420
71BMPR20.52734139
72PRKCH0.52270037
73MKNK20.52000327
74TESK20.51942651
75EEF2K0.48944614
76MINK10.48655644
77TTK0.47155907
78CASK0.46919753
79GRK50.46145157
80CDK30.45150704
81MAP3K20.43560763
82MAPK10.42472316
83STK38L0.39755068
84MUSK0.39181489
85CAMK1G0.38533936
86LIMK10.38033055
87DYRK1A0.37995227
88PINK10.37783030
89CHEK10.36083489
90CDK120.36038516
91VRK20.34503656
92SGK10.34269101
93NUAK10.33645333
94CSNK1A10.33538588
95PRKCE0.33336652
96ADRBK20.31404197
97PAK10.30785586
98OXSR10.29635066
99BRSK20.29528698
100MARK10.29297117
101WEE10.29012940
102PLK30.27426699
103PRKCG0.27307150
104FGFR20.26003188
105ATM0.24661193
106NTRK20.24544772
107PAK20.22679321
108MTOR0.20331961
109NEK60.19897122
110MARK20.19053712
111PKN10.18550614
112ATR0.18051451
113PRKAA10.17085569
114RIPK10.16962610
115YES10.16925137
116MAP3K100.15938694
117CAMKK10.15720614
118CDC70.14573639
119MARK30.14477328
120MAPKAPK50.14018158
121PRKCZ0.13475241
122PLK10.13236963
123PRKG20.13203047
124RPS6KB10.13202223
125BRSK10.10288496
126PRKCQ0.09421433
127CDK150.08199129
128PAK40.07560144
129PRKG10.06558716
130CDK180.05887237
131CSNK2A10.05665853
132PRKACG0.05003396
133RPS6KA10.04766855
134GSK3B0.04686009
135CDK11A0.04306818
136CAMK2A0.04211526
137EGFR0.03829897
138CSNK2A20.03750789
139CSNK1D0.03719071
140CDK140.02811632
141PDGFRB0.02774974
142MAP3K50.02751712
143CDK20.02109978
144CSF1R0.02011333
145CDK60.01936750
146STK110.01935497
147ZAP700.01526654
148PRKCB0.01218894
149BRAF0.00516796
150WNK30.00485509
151MAPK80.00460295
152CDK10.00310395
153PRKCA0.00137491
154STK10-0.0300772
155CDK4-0.0296606
156PIM1-0.0288822
157PRKACA-0.0288261
158GSK3A-0.0195488
159RPS6KA3-0.0161071
160PRKACB-0.0154943
161PRKCD-0.0068130
162MAP3K4-0.0003689

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.53509447
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34069143
3Fatty acid biosynthesis_Homo sapiens_hsa000613.91739076
4Pyruvate metabolism_Homo sapiens_hsa006203.62577514
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.58645654
6Vitamin B6 metabolism_Homo sapiens_hsa007503.55876093
7Olfactory transduction_Homo sapiens_hsa047403.05573997
8Propanoate metabolism_Homo sapiens_hsa006402.86300688
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76605590
10Linoleic acid metabolism_Homo sapiens_hsa005912.68967416
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.63458992
12Glucagon signaling pathway_Homo sapiens_hsa049222.55168974
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.49702858
14Basal transcription factors_Homo sapiens_hsa030222.43920810
15Tyrosine metabolism_Homo sapiens_hsa003502.39560965
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.32297475
17Selenocompound metabolism_Homo sapiens_hsa004502.28367572
18Proteasome_Homo sapiens_hsa030502.26603780
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.24006995
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20657034
21Phototransduction_Homo sapiens_hsa047442.13308134
22Glycerolipid metabolism_Homo sapiens_hsa005612.02622289
23Nitrogen metabolism_Homo sapiens_hsa009101.98688025
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94851967
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93919568
26Pentose phosphate pathway_Homo sapiens_hsa000301.90784712
27Oocyte meiosis_Homo sapiens_hsa041141.90064830
28Butanoate metabolism_Homo sapiens_hsa006501.86000578
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78951412
30PPAR signaling pathway_Homo sapiens_hsa033201.78830505
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.58447493
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.57725180
33Non-homologous end-joining_Homo sapiens_hsa034501.56476349
34RNA polymerase_Homo sapiens_hsa030201.55175678
35Carbon metabolism_Homo sapiens_hsa012001.51201097
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49474430
37Mineral absorption_Homo sapiens_hsa049781.48244377
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.46137481
39Cardiac muscle contraction_Homo sapiens_hsa042601.46089130
40Amphetamine addiction_Homo sapiens_hsa050311.46044764
41Melanogenesis_Homo sapiens_hsa049161.44086251
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37817600
43Fanconi anemia pathway_Homo sapiens_hsa034601.35634691
44Fructose and mannose metabolism_Homo sapiens_hsa000511.35582394
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34595983
46Fat digestion and absorption_Homo sapiens_hsa049751.31684619
47beta-Alanine metabolism_Homo sapiens_hsa004101.31456492
48Dorso-ventral axis formation_Homo sapiens_hsa043201.31300385
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29142618
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28360230
51Ether lipid metabolism_Homo sapiens_hsa005651.27781032
52Huntingtons disease_Homo sapiens_hsa050161.25762764
53Lysine degradation_Homo sapiens_hsa003101.19264258
54Glutathione metabolism_Homo sapiens_hsa004801.16846297
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15445879
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15128018
57Fatty acid degradation_Homo sapiens_hsa000711.14775518
58Fatty acid metabolism_Homo sapiens_hsa012121.14398294
59Peroxisome_Homo sapiens_hsa041461.09929773
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.08638187
61Renin secretion_Homo sapiens_hsa049241.06887878
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05293151
63Collecting duct acid secretion_Homo sapiens_hsa049661.03133472
64Systemic lupus erythematosus_Homo sapiens_hsa053221.02300317
65Purine metabolism_Homo sapiens_hsa002301.02163726
66Antigen processing and presentation_Homo sapiens_hsa046121.01739095
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00336962
68Homologous recombination_Homo sapiens_hsa034400.95476715
69Oxidative phosphorylation_Homo sapiens_hsa001900.94641221
70mRNA surveillance pathway_Homo sapiens_hsa030150.94241828
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93293556
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91464637
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91355464
74Biosynthesis of amino acids_Homo sapiens_hsa012300.89777381
75Morphine addiction_Homo sapiens_hsa050320.84153948
76Bile secretion_Homo sapiens_hsa049760.81909603
77Insulin secretion_Homo sapiens_hsa049110.81739792
78RNA transport_Homo sapiens_hsa030130.81017959
79Renin-angiotensin system_Homo sapiens_hsa046140.79267042
80Chemical carcinogenesis_Homo sapiens_hsa052040.79052659
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78315478
82Inositol phosphate metabolism_Homo sapiens_hsa005620.75901972
83Allograft rejection_Homo sapiens_hsa053300.75572362
84Tryptophan metabolism_Homo sapiens_hsa003800.74029179
85Arginine and proline metabolism_Homo sapiens_hsa003300.73616762
86Parkinsons disease_Homo sapiens_hsa050120.72665205
87Thyroid hormone synthesis_Homo sapiens_hsa049180.72331428
88Graft-versus-host disease_Homo sapiens_hsa053320.70229799
89Autoimmune thyroid disease_Homo sapiens_hsa053200.69685691
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69288887
91Estrogen signaling pathway_Homo sapiens_hsa049150.68314709
92Hedgehog signaling pathway_Homo sapiens_hsa043400.67937242
93Long-term potentiation_Homo sapiens_hsa047200.67181007
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66939640
95Synaptic vesicle cycle_Homo sapiens_hsa047210.66457513
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.65150381
97Nicotine addiction_Homo sapiens_hsa050330.62860095
98Calcium signaling pathway_Homo sapiens_hsa040200.62577159
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61473424
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.61015221
101Protein export_Homo sapiens_hsa030600.60705238
102Arachidonic acid metabolism_Homo sapiens_hsa005900.60429946
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59685134
104Alzheimers disease_Homo sapiens_hsa050100.59105926
105Histidine metabolism_Homo sapiens_hsa003400.57767374
106Protein digestion and absorption_Homo sapiens_hsa049740.56160448
107Galactose metabolism_Homo sapiens_hsa000520.54299652
108Adherens junction_Homo sapiens_hsa045200.53657963
109Pancreatic secretion_Homo sapiens_hsa049720.52436367
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52304794
111ABC transporters_Homo sapiens_hsa020100.51566967
112Legionellosis_Homo sapiens_hsa051340.51396422
113Salivary secretion_Homo sapiens_hsa049700.49455259
114Taste transduction_Homo sapiens_hsa047420.47773432
115Gastric acid secretion_Homo sapiens_hsa049710.46753562
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46737030
117Metabolic pathways_Homo sapiens_hsa011000.45074280
118Alcoholism_Homo sapiens_hsa050340.45026286
119N-Glycan biosynthesis_Homo sapiens_hsa005100.43572530
120Sulfur metabolism_Homo sapiens_hsa009200.42105262
121AMPK signaling pathway_Homo sapiens_hsa041520.41355459
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41073243
123Circadian entrainment_Homo sapiens_hsa047130.40578605
124Endocytosis_Homo sapiens_hsa041440.40547870
125RNA degradation_Homo sapiens_hsa030180.40113783
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40054240
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39267938
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38657177
129Type I diabetes mellitus_Homo sapiens_hsa049400.38420733
130Fatty acid elongation_Homo sapiens_hsa000620.36262323
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36169986
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36133835
133cAMP signaling pathway_Homo sapiens_hsa040240.35783211
134Retinol metabolism_Homo sapiens_hsa008300.34909440
135Sphingolipid metabolism_Homo sapiens_hsa006000.32862427
136One carbon pool by folate_Homo sapiens_hsa006700.32106865
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.32067789
138VEGF signaling pathway_Homo sapiens_hsa043700.20267579
139Cocaine addiction_Homo sapiens_hsa050300.20113661
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19342635
141Pyrimidine metabolism_Homo sapiens_hsa002400.16467763
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16316883
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13919120
144HIF-1 signaling pathway_Homo sapiens_hsa040660.10261435
145Viral carcinogenesis_Homo sapiens_hsa052030.09522786
146Salmonella infection_Homo sapiens_hsa051320.09307712
147Wnt signaling pathway_Homo sapiens_hsa043100.06647374
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.05953835
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05331609

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