ROCK1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.82853934
2cilium or flagellum-dependent cell motility (GO:0001539)7.72877264
3tryptophan catabolic process (GO:0006569)6.75610253
4indole-containing compound catabolic process (GO:0042436)6.75610253
5indolalkylamine catabolic process (GO:0046218)6.75610253
6indolalkylamine metabolic process (GO:0006586)6.50236396
7kynurenine metabolic process (GO:0070189)6.42327438
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)6.23303673
9regulation of hippo signaling (GO:0035330)5.78892278
10tryptophan metabolic process (GO:0006568)5.51446788
11regulation of posttranscriptional gene silencing (GO:0060147)5.50483180
12regulation of gene silencing by miRNA (GO:0060964)5.50483180
13regulation of gene silencing by RNA (GO:0060966)5.50483180
14tachykinin receptor signaling pathway (GO:0007217)5.25745470
15UDP-N-acetylglucosamine metabolic process (GO:0006047)4.81592621
16indole-containing compound metabolic process (GO:0042430)4.73511170
17photoreceptor cell maintenance (GO:0045494)4.64561005
18negative regulation of cytosolic calcium ion concentration (GO:0051481)4.59947505
19respiratory tube development (GO:0030323)4.54645310
20monoubiquitinated protein deubiquitination (GO:0035520)4.53987358
21auditory receptor cell stereocilium organization (GO:0060088)4.52903595
22NAD biosynthetic process (GO:0009435)4.48115767
23benzene-containing compound metabolic process (GO:0042537)4.47046903
24positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.46267223
25behavioral response to ethanol (GO:0048149)4.46042896
26reflex (GO:0060004)4.43802678
27histone H4-K12 acetylation (GO:0043983)4.40208085
28detection of mechanical stimulus involved in sensory perception (GO:0050974)4.27049187
29serotonin metabolic process (GO:0042428)4.15536228
30detection of light stimulus involved in sensory perception (GO:0050962)4.12051628
31detection of light stimulus involved in visual perception (GO:0050908)4.12051628
32negative regulation of calcium ion transport into cytosol (GO:0010523)4.10248623
33protein K48-linked deubiquitination (GO:0071108)4.08897951
34cellular ketone body metabolic process (GO:0046950)3.95357804
35cellular biogenic amine catabolic process (GO:0042402)3.87330468
36amine catabolic process (GO:0009310)3.87330468
37detection of mechanical stimulus (GO:0050982)3.77148283
38flavonoid metabolic process (GO:0009812)3.75767833
39primary amino compound metabolic process (GO:1901160)3.71889541
40lipid translocation (GO:0034204)3.68867572
41phospholipid translocation (GO:0045332)3.68867572
42positive regulation of developmental pigmentation (GO:0048087)3.67291551
43righting reflex (GO:0060013)3.66176950
44regulation of pigment cell differentiation (GO:0050932)3.64363462
45thyroid hormone metabolic process (GO:0042403)3.63872253
46aromatic amino acid family metabolic process (GO:0009072)3.63036843
47neural tube formation (GO:0001841)3.59571444
48aromatic amino acid family catabolic process (GO:0009074)3.56575497
49regulation of acrosome reaction (GO:0060046)3.55859756
50behavioral response to nicotine (GO:0035095)3.55418921
51snRNA transcription (GO:0009301)3.54266110
52regulation of skeletal muscle contraction (GO:0014819)3.53457531
53response to misfolded protein (GO:0051788)3.49527702
54ketone body metabolic process (GO:1902224)3.45975289
55inner ear receptor stereocilium organization (GO:0060122)3.43320843
56dicarboxylic acid biosynthetic process (GO:0043650)3.40784179
57cellular response to sterol (GO:0036315)3.38369828
58negative regulation of keratinocyte proliferation (GO:0010839)3.37789525
59opioid receptor signaling pathway (GO:0038003)3.36833852
60nicotinamide nucleotide biosynthetic process (GO:0019359)3.36790862
61pyridine nucleotide biosynthetic process (GO:0019363)3.36790862
62xenobiotic catabolic process (GO:0042178)3.32751301
63negative regulation of complement activation (GO:0045916)3.32531221
64membrane depolarization during action potential (GO:0086010)3.32434799
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27105975
66sphingoid metabolic process (GO:0046519)3.25417865
67cytokine biosynthetic process (GO:0042089)3.21330829
68regulation of establishment of cell polarity (GO:2000114)3.21056660
69sulfation (GO:0051923)3.17991127
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15662034
71regulation of sarcomere organization (GO:0060297)3.15103931
72cilium movement (GO:0003341)3.14062565
73positive regulation of uterine smooth muscle contraction (GO:0070474)3.13595010
74neuronal action potential (GO:0019228)3.11667990
75regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09984725
76protein K63-linked deubiquitination (GO:0070536)3.09845261
77oxidative demethylation (GO:0070989)3.09614748
78positive regulation of cell cycle G2/M phase transition (GO:1902751)3.07129955
79positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.07129955
80response to nitrosative stress (GO:0051409)3.06845667
81inner cell mass cell proliferation (GO:0001833)3.06148526
82dicarboxylic acid catabolic process (GO:0043649)3.04598907
83positive regulation of vasculogenesis (GO:2001214)2.96611574
84regulation of establishment or maintenance of cell polarity (GO:0032878)2.96163511
85regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.95981529
86negative regulation of cAMP-mediated signaling (GO:0043951)2.93011128
87negative regulation of protein activation cascade (GO:2000258)2.88972478
88establishment of protein localization to Golgi (GO:0072600)2.88277267
89gamma-aminobutyric acid transport (GO:0015812)2.87228658
90negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.83975009
91drug catabolic process (GO:0042737)2.83439587
92retinal cone cell development (GO:0046549)2.81639649
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.78882550
94cellular response to ethanol (GO:0071361)2.78809060
95regulation of vasculogenesis (GO:2001212)2.76787182
96one-carbon compound transport (GO:0019755)2.75242810
97skeletal muscle tissue regeneration (GO:0043403)2.72084551
98striated muscle atrophy (GO:0014891)2.71806942
99response to caffeine (GO:0031000)2.70001059
100L-methionine biosynthetic process (GO:0071265)2.69826394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.70601152
2VDR_22108803_ChIP-Seq_LS180_Human3.63351867
3EZH2_22144423_ChIP-Seq_EOC_Human3.40267421
4IGF1R_20145208_ChIP-Seq_DFB_Human2.99838798
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75852206
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56054309
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35980521
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30852313
9TAF15_26573619_Chip-Seq_HEK293_Human2.24992085
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17700182
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.17374736
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16389291
13DROSHA_22980978_ChIP-Seq_HELA_Human2.08510359
14STAT3_23295773_ChIP-Seq_U87_Human2.05256963
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01477887
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99957448
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98533649
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.93882904
19ZNF274_21170338_ChIP-Seq_K562_Hela1.92666807
20P300_19829295_ChIP-Seq_ESCs_Human1.88324151
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86708354
22BCAT_22108803_ChIP-Seq_LS180_Human1.81865372
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80449373
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78949832
25SMAD4_21799915_ChIP-Seq_A2780_Human1.77552139
26ER_23166858_ChIP-Seq_MCF-7_Human1.76693372
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73379089
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69966833
29TCF4_23295773_ChIP-Seq_U87_Human1.67424561
30AR_21572438_ChIP-Seq_LNCaP_Human1.61509227
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53959400
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52674081
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52674081
34CBP_20019798_ChIP-Seq_JUKART_Human1.50444585
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50444585
36PRDM14_20953172_ChIP-Seq_ESCs_Human1.49960869
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49073645
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48394552
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47988890
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.47841758
41FUS_26573619_Chip-Seq_HEK293_Human1.47505355
42EWS_26573619_Chip-Seq_HEK293_Human1.45129356
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44021254
44AR_25329375_ChIP-Seq_VCAP_Human1.43191188
45TCF4_22108803_ChIP-Seq_LS180_Human1.42851770
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42255582
47AHR_22903824_ChIP-Seq_MCF-7_Human1.40368903
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39025149
49RXR_22108803_ChIP-Seq_LS180_Human1.38683705
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.34961217
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.33275921
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32936115
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32643817
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31686991
55RUNX2_22187159_ChIP-Seq_PCA_Human1.31233444
56CDX2_22108803_ChIP-Seq_LS180_Human1.29549070
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29407286
58NANOG_19829295_ChIP-Seq_ESCs_Human1.23911117
59SOX2_19829295_ChIP-Seq_ESCs_Human1.23911117
60CJUN_26792858_Chip-Seq_BT549_Human1.22738443
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.22440857
62REST_21632747_ChIP-Seq_MESCs_Mouse1.22147386
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.21889753
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21314074
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20659694
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19891750
67KDM2B_26808549_Chip-Seq_REH_Human1.19536469
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19228524
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16471130
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.13562799
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12353736
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12312294
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.12036891
74OCT1_27270436_Chip-Seq_PROSTATE_Human1.11738776
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.11386568
76AR_19668381_ChIP-Seq_PC3_Human1.11241734
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10886134
78TP53_18474530_ChIP-ChIP_U2OS_Human1.10163598
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08513680
80TP53_16413492_ChIP-PET_HCT116_Human1.07735475
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.07540600
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07017299
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04817230
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04301044
85TP53_22573176_ChIP-Seq_HFKS_Human1.04048803
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03936184
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03543557
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.02181644
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01956890
90SMAD3_21741376_ChIP-Seq_ESCs_Human1.01689921
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00266317
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99618330
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99554329
94TP63_23658742_ChIP-Seq_EP156T_Human0.98504663
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98473687
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98473687
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98448855
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98405206
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.97364329
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95286586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.70189118
2MP0008057_abnormal_DNA_replication4.20035027
3MP0003195_calcinosis3.95813995
4MP0001501_abnormal_sleep_pattern3.82088295
5MP0003950_abnormal_plasma_membrane3.23836000
6MP0005377_hearing/vestibular/ear_phenot3.00410265
7MP0003878_abnormal_ear_physiology3.00410265
8MP0001968_abnormal_touch/_nociception2.94364782
9MP0003879_abnormal_hair_cell2.91982218
10MP0001485_abnormal_pinna_reflex2.87246244
11MP0003646_muscle_fatigue2.85794754
12MP0005670_abnormal_white_adipose2.85498908
13MP0009046_muscle_twitch2.82596320
14MP0005551_abnormal_eye_electrophysiolog2.61158695
15MP0003045_fibrosis2.56649745
16MP0002736_abnormal_nociception_after2.54161573
17MP0000569_abnormal_digit_pigmentation2.43002845
18MP0004043_abnormal_pH_regulation2.29906453
19MP0006054_spinal_hemorrhage2.25720141
20MP0003136_yellow_coat_color2.20634008
21MP0009053_abnormal_anal_canal1.99797321
22MP0003252_abnormal_bile_duct1.98166420
23MP0010386_abnormal_urinary_bladder1.98063505
24MP0005410_abnormal_fertilization1.91044549
25MP0006276_abnormal_autonomic_nervous1.90140770
26MP0009745_abnormal_behavioral_response1.75768431
27MP0000538_abnormal_urinary_bladder1.73313207
28MP0005167_abnormal_blood-brain_barrier1.55148010
29MP0002168_other_aberrant_phenotype1.51091583
30MP0002733_abnormal_thermal_nociception1.50992434
31MP0002928_abnormal_bile_duct1.50603950
32MP0005310_abnormal_salivary_gland1.49712989
33MP0000427_abnormal_hair_cycle1.44917973
34MP0001664_abnormal_digestion1.41179073
35MP0000230_abnormal_systemic_arterial1.39846906
36MP0008961_abnormal_basal_metabolism1.36314671
37MP0005646_abnormal_pituitary_gland1.35714557
38MP0001970_abnormal_pain_threshold1.35685406
39MP0001486_abnormal_startle_reflex1.32670628
40MP0000383_abnormal_hair_follicle1.31148032
41MP0003633_abnormal_nervous_system1.29703154
42MP0002272_abnormal_nervous_system1.29580108
43MP0005645_abnormal_hypothalamus_physiol1.28783643
44MP0002064_seizures1.27936872
45MP0008872_abnormal_physiological_respon1.26419834
46MP0002735_abnormal_chemical_nociception1.23119031
47MP0002067_abnormal_sensory_capabilities1.21576660
48MP0002572_abnormal_emotion/affect_behav1.20408920
49MP0003183_abnormal_peptide_metabolism1.20070577
50MP0001963_abnormal_hearing_physiology1.15605563
51MP0002229_neurodegeneration1.15255693
52MP0002876_abnormal_thyroid_physiology1.13808040
53MP0005253_abnormal_eye_physiology1.12714094
54MP0004130_abnormal_muscle_cell1.09907449
55MP0001986_abnormal_taste_sensitivity1.09548579
56MP0005085_abnormal_gallbladder_physiolo1.09003184
57MP0005647_abnormal_sex_gland1.07197646
58MP0003635_abnormal_synaptic_transmissio1.04047030
59MP0005360_urolithiasis1.02602817
60MP0000371_diluted_coat_color1.01710240
61MP0005503_abnormal_tendon_morphology1.00505850
62MP0004036_abnormal_muscle_relaxation1.00182686
63MP0004147_increased_porphyrin_level0.99944870
64MP0003698_abnormal_male_reproductive0.99885093
65MP0002693_abnormal_pancreas_physiology0.98279639
66MP0004145_abnormal_muscle_electrophysio0.97803500
67MP0005266_abnormal_metabolism0.97244932
68MP0000026_abnormal_inner_ear0.94022739
69MP0005171_absent_coat_pigmentation0.93716250
70MP0004085_abnormal_heartbeat0.91096216
71MP0005595_abnormal_vascular_smooth0.90756147
72MP0001756_abnormal_urination0.88289232
73MP0005395_other_phenotype0.88236252
74MP0009764_decreased_sensitivity_to0.87099247
75MP0003638_abnormal_response/metabolism_0.84455328
76MP0004742_abnormal_vestibular_system0.84293988
77MP0000372_irregular_coat_pigmentation0.84221921
78MP0002090_abnormal_vision0.83611241
79MP0003631_nervous_system_phenotype0.83180943
80MP0006082_CNS_inflammation0.82109655
81MP0001661_extended_life_span0.81581233
82MP0001984_abnormal_olfaction0.81541235
83MP0000470_abnormal_stomach_morphology0.81435764
84MP0002102_abnormal_ear_morphology0.80406338
85MP0002557_abnormal_social/conspecific_i0.78830328
86MP0004215_abnormal_myocardial_fiber0.77174782
87MP0003959_abnormal_lean_body0.76753376
88MP0005275_abnormal_skin_tensile0.74984636
89MP0002938_white_spotting0.73757800
90MP0003119_abnormal_digestive_system0.72433647
91MP0001873_stomach_inflammation0.69756156
92MP0004142_abnormal_muscle_tone0.69684518
93MP0003868_abnormal_feces_composition0.68604056
94MP0000631_abnormal_neuroendocrine_gland0.68420062
95MP0003941_abnormal_skin_development0.66983067
96MP0005195_abnormal_posterior_eye0.66285470
97MP0005174_abnormal_tail_pigmentation0.63844737
98MP0002063_abnormal_learning/memory/cond0.62561542
99MP0001440_abnormal_grooming_behavior0.60330133
100MP0001765_abnormal_ion_homeostasis0.60006718

Predicted human phenotypes

RankGene SetZ-score
1Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.90748838
2Increased neuronal autofluorescent lipopigment (HP:0002074)5.65986320
3Genetic anticipation (HP:0003743)5.37557634
4Attenuation of retinal blood vessels (HP:0007843)5.07649935
5Ileus (HP:0002595)5.00602564
6Central scotoma (HP:0000603)4.69176468
7Pancreatic cysts (HP:0001737)4.68766857
8Increased cerebral lipofuscin (HP:0011813)4.65895125
9Congenital sensorineural hearing impairment (HP:0008527)4.62314712
10Gaze-evoked nystagmus (HP:0000640)4.62159120
11Clumsiness (HP:0002312)4.49785190
12Progressive cerebellar ataxia (HP:0002073)4.35529578
13Bony spicule pigmentary retinopathy (HP:0007737)4.31250616
14Dysmetric saccades (HP:0000641)3.91055796
15Cystic liver disease (HP:0006706)3.62201516
16True hermaphroditism (HP:0010459)3.47240541
17Pancreatic fibrosis (HP:0100732)3.43226749
18Abnormal ciliary motility (HP:0012262)3.40039751
19Facial diplegia (HP:0001349)3.33975952
20Congenital stationary night blindness (HP:0007642)3.33596711
21Scotoma (HP:0000575)3.29153099
22Decreased circulating renin level (HP:0003351)3.24416495
23Abnormality of binocular vision (HP:0011514)3.22414809
24Diplopia (HP:0000651)3.22414809
25Increased corneal curvature (HP:0100692)3.18904190
26Keratoconus (HP:0000563)3.18904190
27Abolished electroretinogram (ERG) (HP:0000550)3.07720786
28Abnormality of the renal cortex (HP:0011035)3.03149871
29Hyperventilation (HP:0002883)2.95516319
30Constricted visual fields (HP:0001133)2.89390629
31Focal seizures (HP:0007359)2.87427506
32Potter facies (HP:0002009)2.75999412
33Facial shape deformation (HP:0011334)2.75999412
34Protruding tongue (HP:0010808)2.74202394
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.71740361
36Abnormal respiratory motile cilium physiology (HP:0012261)2.70591074
37Preaxial foot polydactyly (HP:0001841)2.69454508
38Chronic hepatic failure (HP:0100626)2.60984076
39Enlarged kidneys (HP:0000105)2.57575599
40Abnormality of the renal medulla (HP:0100957)2.52178593
41Large for gestational age (HP:0001520)2.51769238
42Abnormal drinking behavior (HP:0030082)2.50454025
43Polydipsia (HP:0001959)2.50454025
44Thyroid-stimulating hormone excess (HP:0002925)2.48070709
45Abnormality of alanine metabolism (HP:0010916)2.46651016
46Hyperalaninemia (HP:0003348)2.46651016
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46651016
48Absent/shortened dynein arms (HP:0200106)2.44543593
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.44543593
50Congenital hepatic fibrosis (HP:0002612)2.43088139
51Dialeptic seizures (HP:0011146)2.43075883
52Febrile seizures (HP:0002373)2.42792420
53Tubulointerstitial fibrosis (HP:0005576)2.39542594
54Absent speech (HP:0001344)2.38281132
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33941923
56Sclerocornea (HP:0000647)2.32082181
57Absence seizures (HP:0002121)2.30582794
58Prostate neoplasm (HP:0100787)2.29703580
59Cerebellar dysplasia (HP:0007033)2.29624436
60Abnormality of macular pigmentation (HP:0008002)2.27888478
61Furrowed tongue (HP:0000221)2.26523001
62Fair hair (HP:0002286)2.26433208
63Medial flaring of the eyebrow (HP:0010747)2.24815217
64Progressive visual loss (HP:0000529)2.23335487
65Hypothermia (HP:0002045)2.21336622
66Difficulty walking (HP:0002355)2.20331226
67Molar tooth sign on MRI (HP:0002419)2.19968417
68Abnormality of midbrain morphology (HP:0002418)2.19968417
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15287160
70Nephronophthisis (HP:0000090)2.11583984
71Tubular atrophy (HP:0000092)2.10402313
72Type II lissencephaly (HP:0007260)2.08875642
73Tubulointerstitial abnormality (HP:0001969)2.07425842
74Hydroxyprolinuria (HP:0003080)2.04921012
75Abnormality of proline metabolism (HP:0010907)2.04921012
76Portal hypertension (HP:0001409)2.01562205
77Retinitis pigmentosa (HP:0000510)2.01454431
78Urinary bladder sphincter dysfunction (HP:0002839)2.01238076
79Hypoplastic ischia (HP:0003175)1.99708834
80Proximal tubulopathy (HP:0000114)1.99098426
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.97979863
82Abnormality of the ischium (HP:0003174)1.97465085
83Polyuria (HP:0000103)1.96571320
84Poikiloderma (HP:0001029)1.96002252
85Decreased central vision (HP:0007663)1.92381976
86Postural instability (HP:0002172)1.91906028
87Spastic paraplegia (HP:0001258)1.91048612
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89283109
89Abnormality of renin-angiotensin system (HP:0000847)1.88631407
90Impaired smooth pursuit (HP:0007772)1.87533349
91Severe visual impairment (HP:0001141)1.86351908
92Abnormal rod and cone electroretinograms (HP:0008323)1.86149312
93Abnormality of the hepatic vasculature (HP:0006707)1.86013770
94Inability to walk (HP:0002540)1.84785150
95Congenital primary aphakia (HP:0007707)1.84291072
96Gait imbalance (HP:0002141)1.84028363
97Focal motor seizures (HP:0011153)1.82835397
98Small hand (HP:0200055)1.80854796
99Hyperkalemia (HP:0002153)1.80487663
100Opisthotonus (HP:0002179)1.77185655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.75677978
2ACVR1B2.80854823
3BMPR1B2.80753749
4PIK3CG2.77678623
5INSRR2.34775497
6FRK12.3801447
7NTRK31.95566994
8OXSR11.72846042
9STK38L1.71904703
10TAOK31.71292623
11ADRBK11.61016966
12TIE11.56457430
13GRK11.53685291
14PINK11.46875298
15ZAK1.40829023
16TNK21.33491243
17STK391.29781408
18TGFBR11.20749537
19TEC1.20189965
20DAPK21.19347205
21MKNK21.12236903
22FER1.11637872
23CDK191.07831613
24KDR1.00572415
25WNK30.99310843
26STK380.98632459
27LATS10.96984777
28PRKCG0.93976334
29MAP3K70.91444817
30STK30.89525622
31PTK2B0.84292538
32ITK0.83706816
33PRKCE0.78243436
34TRPM70.76769367
35MYLK0.76709796
36PRKAA20.76395884
37NUAK10.69642671
38PIK3CA0.69375747
39MELK0.67771049
40KIT0.66471321
41TXK0.66172517
42CASK0.64087652
43CAMK2A0.63661026
44MAPKAPK30.58264087
45TLK10.56612276
46MAPK130.56076334
47WNK40.54177844
48NEK20.53952200
49MARK30.50412227
50MUSK0.49803204
51SGK20.49491224
52MAP3K40.49097578
53BTK0.47382416
54MAPK150.46586867
55MAPKAPK50.46417954
56IRAK10.45747242
57CHUK0.44967337
58IKBKB0.44684518
59PRKG20.43654507
60PRKACB0.40846982
61OBSCN0.40426785
62CDK30.39155247
63CAMK10.38760990
64DDR20.38505043
65PRKAA10.38384666
66MAPK110.38275534
67MKNK10.36819974
68NLK0.35302862
69PDK10.35252447
70PKN10.34472765
71SYK0.33487100
72AKT30.32401351
73PRKCB0.32366852
74PRKCH0.31415320
75CHEK20.31342085
76MAP2K10.31035408
77PRKCA0.30659730
78RPS6KA60.30446090
79GRK70.29554639
80MAP2K60.29464952
81FES0.29460741
82PRKACA0.29241598
83SGK2230.26427470
84SGK4940.26427470
85RPS6KA50.26190617
86BLK0.25013872
87MAP4K20.24828303
88PRKCQ0.23251961
89HCK0.22305901
90GRK50.21721516
91IGF1R0.21170095
92LCK0.20393350
93MAP3K90.20286676
94RPS6KA30.20119030
95EIF2AK30.19081366
96PRKG10.18279661
97MAPK70.17292086
98CSNK1D0.17238718
99AKT10.17232559
100LYN0.17217471

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020103.53178283
2Tryptophan metabolism_Homo sapiens_hsa003803.21397323
3Butanoate metabolism_Homo sapiens_hsa006502.99324677
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54521397
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.34690487
6Nicotine addiction_Homo sapiens_hsa050332.32436990
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.30476871
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21798818
9Linoleic acid metabolism_Homo sapiens_hsa005912.07097378
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05801837
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03236399
12Phototransduction_Homo sapiens_hsa047442.01460039
13Nitrogen metabolism_Homo sapiens_hsa009101.95204682
14Histidine metabolism_Homo sapiens_hsa003401.85399718
15Morphine addiction_Homo sapiens_hsa050321.85142027
16Homologous recombination_Homo sapiens_hsa034401.74996372
17Chemical carcinogenesis_Homo sapiens_hsa052041.74519588
18Retinol metabolism_Homo sapiens_hsa008301.72850258
19Olfactory transduction_Homo sapiens_hsa047401.72785268
20Glycerolipid metabolism_Homo sapiens_hsa005611.67176372
21Salivary secretion_Homo sapiens_hsa049701.59924490
22Ovarian steroidogenesis_Homo sapiens_hsa049131.59415320
23Taste transduction_Homo sapiens_hsa047421.59327201
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57995982
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.57749448
26Circadian entrainment_Homo sapiens_hsa047131.49168850
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47818825
28Calcium signaling pathway_Homo sapiens_hsa040201.42568913
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39581743
30Ether lipid metabolism_Homo sapiens_hsa005651.35683609
31Serotonergic synapse_Homo sapiens_hsa047261.30858365
32Glutamatergic synapse_Homo sapiens_hsa047241.29288856
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26861751
34beta-Alanine metabolism_Homo sapiens_hsa004101.26136886
35GABAergic synapse_Homo sapiens_hsa047271.17168851
36Pancreatic secretion_Homo sapiens_hsa049721.13389966
37Graft-versus-host disease_Homo sapiens_hsa053321.13310641
38Fatty acid biosynthesis_Homo sapiens_hsa000611.12311294
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10117119
40Sphingolipid metabolism_Homo sapiens_hsa006001.05941586
41Arachidonic acid metabolism_Homo sapiens_hsa005901.04225397
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03823897
43Gastric acid secretion_Homo sapiens_hsa049711.02348924
44Selenocompound metabolism_Homo sapiens_hsa004501.01434553
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01404628
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98262640
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.95069557
48Protein digestion and absorption_Homo sapiens_hsa049740.94878287
49Fatty acid degradation_Homo sapiens_hsa000710.89314995
50Oxytocin signaling pathway_Homo sapiens_hsa049210.88114607
51Dorso-ventral axis formation_Homo sapiens_hsa043200.86132340
52Sulfur relay system_Homo sapiens_hsa041220.85934160
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84152909
54Insulin secretion_Homo sapiens_hsa049110.83441268
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.81674929
56Renin secretion_Homo sapiens_hsa049240.81015549
57Platelet activation_Homo sapiens_hsa046110.79356308
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79045720
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.78351145
60ECM-receptor interaction_Homo sapiens_hsa045120.77488707
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76966813
62Bile secretion_Homo sapiens_hsa049760.76798806
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75603005
64Cholinergic synapse_Homo sapiens_hsa047250.74904215
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72882533
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64182023
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64070897
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.62789242
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59593882
70One carbon pool by folate_Homo sapiens_hsa006700.59395941
71Asthma_Homo sapiens_hsa053100.58227889
72Long-term depression_Homo sapiens_hsa047300.57887640
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55561731
74cAMP signaling pathway_Homo sapiens_hsa040240.55153583
75Complement and coagulation cascades_Homo sapiens_hsa046100.54369043
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54270635
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52974520
78Lysine degradation_Homo sapiens_hsa003100.52862513
79Propanoate metabolism_Homo sapiens_hsa006400.52337486
80Dilated cardiomyopathy_Homo sapiens_hsa054140.49902596
81Vitamin digestion and absorption_Homo sapiens_hsa049770.49164295
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44086081
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43435219
84N-Glycan biosynthesis_Homo sapiens_hsa005100.43257266
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42003179
86Fat digestion and absorption_Homo sapiens_hsa049750.41732381
87Ras signaling pathway_Homo sapiens_hsa040140.41089267
88Type II diabetes mellitus_Homo sapiens_hsa049300.40545823
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40514708
90Glutathione metabolism_Homo sapiens_hsa004800.40364258
91Mineral absorption_Homo sapiens_hsa049780.39797750
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.39245275
93Starch and sucrose metabolism_Homo sapiens_hsa005000.38856022
94PPAR signaling pathway_Homo sapiens_hsa033200.37998329
95Estrogen signaling pathway_Homo sapiens_hsa049150.37499077
96Fanconi anemia pathway_Homo sapiens_hsa034600.37021038
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36749904
98Autoimmune thyroid disease_Homo sapiens_hsa053200.36104799
99Purine metabolism_Homo sapiens_hsa002300.35756122
100Allograft rejection_Homo sapiens_hsa053300.35483727

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