RNF41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.90749802
2synaptic vesicle maturation (GO:0016188)4.87821010
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83115724
4synaptic vesicle exocytosis (GO:0016079)4.81942481
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76382061
6layer formation in cerebral cortex (GO:0021819)4.69479108
7regulation of synaptic vesicle exocytosis (GO:2000300)4.61609773
8locomotory exploration behavior (GO:0035641)4.59105061
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.42850756
10glutamate secretion (GO:0014047)4.30277172
11positive regulation of synapse maturation (GO:0090129)4.29267445
12negative regulation of microtubule polymerization (GO:0031115)4.25956652
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21486822
14vocalization behavior (GO:0071625)4.20823453
15protein localization to synapse (GO:0035418)4.20730868
16regulation of synapse structural plasticity (GO:0051823)4.20576545
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11554300
18cell migration in hindbrain (GO:0021535)4.05688035
19regulation of synaptic vesicle transport (GO:1902803)3.98570811
20neuron cell-cell adhesion (GO:0007158)3.95343300
21regulation of glutamate receptor signaling pathway (GO:1900449)3.74823083
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.69784386
23exploration behavior (GO:0035640)3.64139301
24positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58869364
25cellular potassium ion homeostasis (GO:0030007)3.50338128
26neuronal action potential propagation (GO:0019227)3.47492346
27neurotransmitter secretion (GO:0007269)3.38220263
28axonal fasciculation (GO:0007413)3.37910405
29regulation of neuronal synaptic plasticity (GO:0048168)3.37883920
30activation of protein kinase A activity (GO:0034199)3.31384646
31positive regulation of vesicle fusion (GO:0031340)3.24715640
32proline transport (GO:0015824)3.23377647
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22088789
34neuron recognition (GO:0008038)3.21875499
35negative regulation of Rho protein signal transduction (GO:0035024)3.21638482
36dendrite morphogenesis (GO:0048813)3.19938944
37synaptic vesicle endocytosis (GO:0048488)3.19934282
38dendritic spine morphogenesis (GO:0060997)3.19007977
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.16642582
40clathrin coat assembly (GO:0048268)3.12826580
41sodium ion export (GO:0071436)3.07921885
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04863718
43neuromuscular process controlling balance (GO:0050885)3.04191483
44mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.03628351
45regulation of neurotransmitter secretion (GO:0046928)2.98515245
46vesicle transport along microtubule (GO:0047496)2.97553503
47membrane depolarization during action potential (GO:0086010)2.96971052
48cerebellar Purkinje cell differentiation (GO:0021702)2.96121056
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95978641
50blood vessel maturation (GO:0001955)2.95575785
51long-term memory (GO:0007616)2.95191063
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94925489
53regulation of synapse maturation (GO:0090128)2.94853524
54positive regulation of membrane potential (GO:0045838)2.87985160
55organelle transport along microtubule (GO:0072384)2.87474407
56synaptic transmission, glutamatergic (GO:0035249)2.85781320
57behavioral response to nicotine (GO:0035095)2.85522621
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85135103
59regulation of synaptic plasticity (GO:0048167)2.85118270
60regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83037958
61axon cargo transport (GO:0008088)2.81967200
62neuromuscular synaptic transmission (GO:0007274)2.79862881
63peptidyl-arginine omega-N-methylation (GO:0035247)2.79088505
64cerebellar Purkinje cell layer development (GO:0021680)2.79014135
65glutamate receptor signaling pathway (GO:0007215)2.76357267
66regulation of postsynaptic membrane potential (GO:0060078)2.75981423
67urinary tract smooth muscle contraction (GO:0014848)2.74616098
68gamma-aminobutyric acid signaling pathway (GO:0007214)2.74522055
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.73848390
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73248375
71membrane depolarization (GO:0051899)2.73205022
72positive regulation of action potential (GO:0045760)2.72552561
73neuron-neuron synaptic transmission (GO:0007270)2.71134314
74regulation of neurotransmitter transport (GO:0051588)2.70850172
75ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.70730734
76negative regulation of cardiac muscle hypertrophy (GO:0010614)2.70306403
77innervation (GO:0060384)2.68891952
78peptidyl-arginine N-methylation (GO:0035246)2.66510383
79peptidyl-arginine methylation (GO:0018216)2.66510383
80neuromuscular process controlling posture (GO:0050884)2.66403590
81negative regulation of muscle hypertrophy (GO:0014741)2.64788519
82cell communication by electrical coupling (GO:0010644)2.64667391
83neuronal action potential (GO:0019228)2.64577459
84dopamine receptor signaling pathway (GO:0007212)2.64334176
85regulation of synaptic transmission, GABAergic (GO:0032228)2.63898996
86synaptic vesicle transport (GO:0048489)2.62807397
87establishment of synaptic vesicle localization (GO:0097480)2.62807397
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62673958
89establishment of nucleus localization (GO:0040023)2.61385426
90synapse assembly (GO:0007416)2.60897154
91neurotransmitter-gated ion channel clustering (GO:0072578)2.58883735
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58715629
93establishment of vesicle localization (GO:0051650)2.58507438
94behavioral defense response (GO:0002209)2.57923566
95behavioral fear response (GO:0001662)2.57923566
96axon extension (GO:0048675)2.57629575
97neurotransmitter transport (GO:0006836)2.57482260
98hippocampus development (GO:0021766)2.57363766
99positive regulation of protein targeting to membrane (GO:0090314)2.57235044
100central nervous system projection neuron axonogenesis (GO:0021952)2.55912054
101ATP hydrolysis coupled proton transport (GO:0015991)2.55823736
102energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.55823736
103postsynaptic membrane organization (GO:0001941)2.55336351
104cerebellar granule cell differentiation (GO:0021707)2.55090298
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.54434759
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.54195478
107regulation of dendritic spine morphogenesis (GO:0061001)2.54044872
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53917365
109calcium ion-dependent exocytosis (GO:0017156)2.53580562
110pyrimidine nucleobase catabolic process (GO:0006208)2.52918378
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.52780121
112regulation of ARF protein signal transduction (GO:0032012)2.52536857
113intraspecies interaction between organisms (GO:0051703)2.52507807
114social behavior (GO:0035176)2.52507807
115positive regulation of dendritic spine development (GO:0060999)2.51080522
116anterograde synaptic vesicle transport (GO:0048490)2.49828289
117type B pancreatic cell proliferation (GO:0044342)2.48514294
118artery development (GO:0060840)2.44499436
119startle response (GO:0001964)2.44148417
120acidic amino acid transport (GO:0015800)2.43559069
121cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.42702624
122positive regulation of neurotransmitter transport (GO:0051590)2.40421738
123regulation of membrane repolarization (GO:0060306)2.39959431
124regulation of action potential (GO:0098900)2.39017248
125nodal signaling pathway (GO:0038092)2.38512833
126pericardium development (GO:0060039)2.38129921
127anterograde axon cargo transport (GO:0008089)2.37971368
128retinal cone cell development (GO:0046549)2.37499970
129positive regulation of synapse assembly (GO:0051965)2.37208502
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33871158
131anatomical structure maturation (GO:0071695)2.33278801
132regulation of respiratory system process (GO:0044065)2.33270656
133response to gravity (GO:0009629)2.31696214
134regulation of vesicle fusion (GO:0031338)2.30958462
135neuronal ion channel clustering (GO:0045161)2.30028728
136dermatan sulfate biosynthetic process (GO:0030208)2.29852885
137neuron remodeling (GO:0016322)2.28692596
138L-glutamate transport (GO:0015813)2.28053967
139fear response (GO:0042596)2.27995026
140inner ear receptor cell development (GO:0060119)2.27704715
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27455246
142regulation of synapse assembly (GO:0051963)2.27057608
143endocardial cushion development (GO:0003197)2.26644386
144glycine transport (GO:0015816)2.25382731
145protein import into peroxisome matrix (GO:0016558)2.25170286
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.24260608
147presynaptic membrane organization (GO:0097090)2.23003118
148regulation of protein targeting to membrane (GO:0090313)2.22096788
149synapse organization (GO:0050808)2.18778345
150synaptic transmission (GO:0007268)2.18651619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47390620
2* REST_21632747_ChIP-Seq_MESCs_Mouse2.94032329
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.70710926
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.67283731
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58323210
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55879869
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.52345091
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.51157058
9GBX2_23144817_ChIP-Seq_PC3_Human2.44063780
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39253997
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37785527
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35864384
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32397279
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32188106
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32188106
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24332742
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21348751
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.19363216
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16882399
20ZNF274_21170338_ChIP-Seq_K562_Hela2.12509060
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11010614
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10469177
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09988119
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.09908018
25DROSHA_22980978_ChIP-Seq_HELA_Human2.09531819
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.09391038
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06970601
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06315181
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.06309225
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02657051
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00008378
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98438932
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96104642
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90646075
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88991455
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85503646
37AR_21572438_ChIP-Seq_LNCaP_Human1.72462539
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68307904
39KDM2B_26808549_Chip-Seq_K562_Human1.66157574
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.65837838
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63503902
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60812536
43* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58137712
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.57714259
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53278917
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49676573
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48028725
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42933875
49TET1_21490601_ChIP-Seq_MESCs_Mouse1.41363196
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40598141
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.39563452
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38731896
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38707310
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33775521
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32324037
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.31907368
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31364817
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30349473
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30091503
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29134493
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27921453
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26644429
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26505702
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25288050
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24721108
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19286608
67CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17448537
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16246077
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15284828
70KDM2B_26808549_Chip-Seq_DND41_Human1.15098712
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15012059
72TAF15_26573619_Chip-Seq_HEK293_Human1.13934916
73TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13412764
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13385226
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13325636
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13325636
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12898059
78IRF1_19129219_ChIP-ChIP_H3396_Human1.11129583
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09685328
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08109599
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.08018301
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07891964
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07213681
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.04845470
85TP53_22127205_ChIP-Seq_IMR90_Human1.03983370
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.02902417
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.02466523
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.01791780
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01687809
90AR_19668381_ChIP-Seq_PC3_Human1.00853688
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00274155
92STAT3_23295773_ChIP-Seq_U87_Human0.99908212
93RNF2_27304074_Chip-Seq_NSC_Mouse0.99134402
94LXR_22292898_ChIP-Seq_THP-1_Human0.98254214
95ZNF263_19887448_ChIP-Seq_K562_Human0.97895360
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97420795
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95181781
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95050176
99CTCF_27219007_Chip-Seq_Bcells_Human0.94623106
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94193019
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93179165
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93115910
103POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.90848924
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.90400412
105SMAD4_21799915_ChIP-Seq_A2780_Human0.90393630
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90094605
107MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89817368
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89483581
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89150645
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88944446
111ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88017826
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86587564
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.86420790
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85191559
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83813385
116OCT4_19829295_ChIP-Seq_ESCs_Human0.83489343
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83143558
118KLF4_19829295_ChIP-Seq_ESCs_Human0.82869310
119P300_19829295_ChIP-Seq_ESCs_Human0.82742479
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82482106
121BRD4_25478319_ChIP-Seq_HGPS_Human0.82217279
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82079224
123JUN_21703547_ChIP-Seq_K562_Human0.82067215
124TCF4_23295773_ChIP-Seq_U87_Human0.81613454
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.81460274
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80887340
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.80644734
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80601888
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.80599029
130SMC4_20622854_ChIP-Seq_HELA_Human0.80208840
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.80077524
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79590631
133* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79350199
134* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78805723
135IGF1R_20145208_ChIP-Seq_DFB_Human0.78762570
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78730038
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.78691978
138CREB1_26743006_Chip-Seq_LNCaP_Human0.78258462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.44558345
2MP0004270_analgesia3.68561987
3MP0003635_abnormal_synaptic_transmissio3.36714293
4MP0003880_abnormal_central_pattern3.27948658
5MP0008438_abnormal_cutaneous_collagen3.23896802
6MP0001968_abnormal_touch/_nociception3.20909104
7MP0002735_abnormal_chemical_nociception2.83580019
8MP0002734_abnormal_mechanical_nocicepti2.69818077
9MP0002063_abnormal_learning/memory/cond2.65136690
10MP0009046_muscle_twitch2.60825356
11MP0004858_abnormal_nervous_system2.58927525
12MP0002736_abnormal_nociception_after2.48858950
13MP0002064_seizures2.40040897
14MP0000569_abnormal_digit_pigmentation2.39479675
15MP0005503_abnormal_tendon_morphology2.37966920
16MP0005423_abnormal_somatic_nervous2.29984032
17MP0002733_abnormal_thermal_nociception2.28513080
18MP0002184_abnormal_innervation2.27007040
19MP0001984_abnormal_olfaction2.22013689
20MP0009745_abnormal_behavioral_response2.21795383
21MP0006276_abnormal_autonomic_nervous2.19289231
22MP0003122_maternal_imprinting2.14868408
23MP0001970_abnormal_pain_threshold2.14666083
24MP0002572_abnormal_emotion/affect_behav2.07434817
25MP0000778_abnormal_nervous_system2.05367039
26MP0004811_abnormal_neuron_physiology2.04020078
27MP0005645_abnormal_hypothalamus_physiol1.96973855
28MP0003705_abnormal_hypodermis_morpholog1.96973089
29MP0002272_abnormal_nervous_system1.95779295
30MP0003279_aneurysm1.94109154
31MP0002102_abnormal_ear_morphology1.77455370
32MP0002067_abnormal_sensory_capabilities1.77154736
33MP0004133_heterotaxia1.75599885
34MP0009384_cardiac_valve_regurgitation1.73507579
35MP0002653_abnormal_ependyma_morphology1.72544991
36MP0001958_emphysema1.71635789
37MP0002254_reproductive_system_inflammat1.69022501
38MP0010386_abnormal_urinary_bladder1.66296239
39MP0001440_abnormal_grooming_behavior1.65911576
40MP0000955_abnormal_spinal_cord1.65479494
41MP0009780_abnormal_chondrocyte_physiolo1.64532454
42MP0002557_abnormal_social/conspecific_i1.63119409
43MP0001486_abnormal_startle_reflex1.57608142
44MP0003329_amyloid_beta_deposits1.54238726
45MP0000750_abnormal_muscle_regeneration1.47504375
46MP0008569_lethality_at_weaning1.46691577
47MP0004272_abnormal_basement_membrane1.44514552
48MP0002909_abnormal_adrenal_gland1.44212544
49MP0002882_abnormal_neuron_morphology1.41392111
50MP0003879_abnormal_hair_cell1.37259911
51MP0001542_abnormal_bone_strength1.34494408
52MP0003942_abnormal_urinary_system1.29825442
53MP0005394_taste/olfaction_phenotype1.29789167
54MP0005499_abnormal_olfactory_system1.29789167
55MP0004130_abnormal_muscle_cell1.28225815
56MP0005623_abnormal_meninges_morphology1.28144762
57MP0005386_behavior/neurological_phenoty1.25559042
58MP0004924_abnormal_behavior1.25559042
59MP0001986_abnormal_taste_sensitivity1.20715936
60MP0002066_abnormal_motor_capabilities/c1.20595672
61MP0002152_abnormal_brain_morphology1.19212258
62MP0002751_abnormal_autonomic_nervous1.16733368
63MP0003121_genomic_imprinting1.14689657
64MP0003183_abnormal_peptide_metabolism1.13709494
65MP0001501_abnormal_sleep_pattern1.13018373
66MP0005084_abnormal_gallbladder_morpholo1.12613763
67MP0000013_abnormal_adipose_tissue1.09923732
68MP0005275_abnormal_skin_tensile1.06988349
69MP0003787_abnormal_imprinting1.06169655
70MP0002295_abnormal_pulmonary_circulatio1.05553418
71MP0003634_abnormal_glial_cell1.04988703
72MP0004134_abnormal_chest_morphology1.04291237
73MP0000751_myopathy1.04216886
74MP0004742_abnormal_vestibular_system1.03867594
75MP0003172_abnormal_lysosome_physiology1.03744048
76MP0002928_abnormal_bile_duct1.03303885
77MP0009250_abnormal_appendicular_skeleto1.00845554
78MP0005508_abnormal_skeleton_morphology0.99715877
79MP0002822_catalepsy0.99261855
80MP0003941_abnormal_skin_development0.94995814
81MP0005410_abnormal_fertilization0.94370281
82MP0003137_abnormal_impulse_conducting0.93671584
83MP0006072_abnormal_retinal_apoptosis0.93622766
84MP0000538_abnormal_urinary_bladder0.93560601
85MP0004145_abnormal_muscle_electrophysio0.93083929
86MP0001661_extended_life_span0.92818722
87MP0003633_abnormal_nervous_system0.91248679
88MP0000759_abnormal_skeletal_muscle0.89897452
89MP0003861_abnormal_nervous_system0.89778719
90MP0001299_abnormal_eye_distance/0.89687484
91MP0002638_abnormal_pupillary_reflex0.89389629
92MP0000749_muscle_degeneration0.87902755
93MP0004885_abnormal_endolymph0.87690387
94MP0003303_peritoneal_inflammation0.87526445
95MP0002234_abnormal_pharynx_morphology0.87039730
96MP0005551_abnormal_eye_electrophysiolog0.86869249
97MP0008789_abnormal_olfactory_epithelium0.85990416
98MP0000767_abnormal_smooth_muscle0.84690050
99MP0004233_abnormal_muscle_weight0.83383772
100MP0002108_abnormal_muscle_morphology0.82076944
101MP0002752_abnormal_somatic_nervous0.81782140
102MP0001177_atelectasis0.81218771
103MP0002160_abnormal_reproductive_system0.80238839
104MP0000003_abnormal_adipose_tissue0.79862453
105MP0000015_abnormal_ear_pigmentation0.79540669
106MP0005595_abnormal_vascular_smooth0.77828047
107MP0001529_abnormal_vocalization0.77669367
108MP0003631_nervous_system_phenotype0.77494528
109MP0001502_abnormal_circadian_rhythm0.77033222
110MP0003959_abnormal_lean_body0.76703522
111MP0002229_neurodegeneration0.76154065
112MP0004085_abnormal_heartbeat0.76127013
113MP0002876_abnormal_thyroid_physiology0.76088467
114MP0003011_delayed_dark_adaptation0.74297323
115MP0000631_abnormal_neuroendocrine_gland0.73323856
116MP0008260_abnormal_autophagy0.72928728
117MP0005620_abnormal_muscle_contractility0.71755304
118MP0002089_abnormal_postnatal_growth/wei0.71051379
119MP0005187_abnormal_penis_morphology0.69958423
120MP0003283_abnormal_digestive_organ0.68382575
121MP0004142_abnormal_muscle_tone0.68149197
122MP0002069_abnormal_eating/drinking_beha0.67417483
123MP0001905_abnormal_dopamine_level0.67362046
124MP0005646_abnormal_pituitary_gland0.66970734
125MP0003091_abnormal_cell_migration0.66570919
126MP0000604_amyloidosis0.66149015
127MP0003123_paternal_imprinting0.63754825
128MP0001348_abnormal_lacrimal_gland0.63011473
129MP0008961_abnormal_basal_metabolism0.60662332
130MP0008877_abnormal_DNA_methylation0.60268628
131MP0000534_abnormal_ureter_morphology0.58732740
132MP0001188_hyperpigmentation0.58197294
133MP0003698_abnormal_male_reproductive0.56658244
134MP0010769_abnormal_survival0.55991366
135MP0003938_abnormal_ear_development0.55478091
136MP0000681_abnormal_thyroid_gland0.53862242
137MP0002081_perinatal_lethality0.53173447
138MP0001963_abnormal_hearing_physiology0.53108796
139MP0010768_mortality/aging0.52829491
140MP0002082_postnatal_lethality0.52446359
141MP0010770_preweaning_lethality0.52446359

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.10813303
2Focal motor seizures (HP:0011153)4.88110083
3Visual hallucinations (HP:0002367)4.30534522
4Focal seizures (HP:0007359)4.24253523
5Mutism (HP:0002300)4.04873049
6Supranuclear gaze palsy (HP:0000605)3.79560610
7Premature rupture of membranes (HP:0001788)3.44276968
8Failure to thrive in infancy (HP:0001531)3.26306343
9Atonic seizures (HP:0010819)3.24756623
10Polyphagia (HP:0002591)3.22602592
11Progressive cerebellar ataxia (HP:0002073)3.21877062
12Entropion (HP:0000621)3.15650172
13Action tremor (HP:0002345)3.10912792
14Ankle clonus (HP:0011448)3.07613469
15Protrusio acetabuli (HP:0003179)3.01219945
16Abnormality of dentin (HP:0010299)2.99244422
17Abnormal eating behavior (HP:0100738)2.97848617
18Absence seizures (HP:0002121)2.92246142
19Epileptic encephalopathy (HP:0200134)2.87306852
20Dialeptic seizures (HP:0011146)2.84977526
21Genu recurvatum (HP:0002816)2.76250491
22Broad metatarsal (HP:0001783)2.75660875
23Calf muscle hypertrophy (HP:0008981)2.73383175
24Depression (HP:0000716)2.73217932
25Truncal ataxia (HP:0002078)2.70281007
26Amyotrophic lateral sclerosis (HP:0007354)2.66172789
27Neoplasm of the adrenal cortex (HP:0100641)2.54917591
28Papilledema (HP:0001085)2.52057479
29Febrile seizures (HP:0002373)2.51090225
30Aortic dissection (HP:0002647)2.50206454
31Progressive inability to walk (HP:0002505)2.46023787
32Termporal pattern (HP:0011008)2.45393271
33Insidious onset (HP:0003587)2.45393271
34Soft skin (HP:0000977)2.44754330
35Vascular tortuosity (HP:0004948)2.43563546
36Limb dystonia (HP:0002451)2.41617434
37Apathy (HP:0000741)2.41553852
38Shallow orbits (HP:0000586)2.39380114
39Wrist flexion contracture (HP:0001239)2.39110024
40Pointed chin (HP:0000307)2.38258975
41Abnormality of the lower motor neuron (HP:0002366)2.37909529
42Poikiloderma (HP:0001029)2.37240060
43Megalencephaly (HP:0001355)2.36445999
44Agitation (HP:0000713)2.36196406
45Aortic aneurysm (HP:0004942)2.35765313
46Neuronal loss in central nervous system (HP:0002529)2.35088860
47Amblyopia (HP:0000646)2.34397537
48Generalized tonic-clonic seizures (HP:0002069)2.32926695
49Diminished motivation (HP:0000745)2.32387613
50Shoulder girdle muscle weakness (HP:0003547)2.32273025
51Broad-based gait (HP:0002136)2.31705140
52Upper limb amyotrophy (HP:0009129)2.31699321
53Distal upper limb amyotrophy (HP:0007149)2.31699321
54Poor eye contact (HP:0000817)2.31545020
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30086424
56Hypoplasia of the brainstem (HP:0002365)2.30086424
57Hyperventilation (HP:0002883)2.29712389
58Urinary urgency (HP:0000012)2.25702907
59Overgrowth (HP:0001548)2.25584709
60Hypoventilation (HP:0002791)2.24948632
61Hyperextensible skin (HP:0000974)2.24463030
62Type II lissencephaly (HP:0007260)2.23942529
63Bladder diverticulum (HP:0000015)2.22691115
64Delusions (HP:0000746)2.22400645
65Impaired smooth pursuit (HP:0007772)2.22321231
66Abnormality of the calf musculature (HP:0001430)2.19842609
67Muscle hypertrophy of the lower extremities (HP:0008968)2.19174619
68Absent speech (HP:0001344)2.16560492
69Drooling (HP:0002307)2.16177238
70Excessive salivation (HP:0003781)2.16177238
71Insomnia (HP:0100785)2.15978407
72Prolonged QT interval (HP:0001657)2.14188937
73Cerebral hypomyelination (HP:0006808)2.13696514
74Pheochromocytoma (HP:0002666)2.13526127
75Aplasia of the musculature (HP:0100854)2.12613858
76Bradycardia (HP:0001662)2.11546885
77Lower limb muscle weakness (HP:0007340)2.09070887
78Impaired social interactions (HP:0000735)2.07854804
79Abnormal social behavior (HP:0012433)2.07854804
80Arterial tortuosity (HP:0005116)2.06808753
81Bowel diverticulosis (HP:0005222)2.06358944
82Gait imbalance (HP:0002141)2.05038409
83Torticollis (HP:0000473)2.03420170
84Upper limb muscle weakness (HP:0003484)2.01638259
85Abnormality of ocular smooth pursuit (HP:0000617)2.00546706
86Retinal dysplasia (HP:0007973)2.00515016
87Peripheral hypomyelination (HP:0007182)2.00042796
88Abnormality of pain sensation (HP:0010832)1.99738142
89Impaired pain sensation (HP:0007328)1.99738142
90Inability to walk (HP:0002540)1.99723331
91Lissencephaly (HP:0001339)1.99693270
92Esotropia (HP:0000565)1.99586316
93Abnormality of the corticospinal tract (HP:0002492)1.97937535
94Thin bony cortex (HP:0002753)1.97654805
95Spastic gait (HP:0002064)1.97477976
96Genetic anticipation (HP:0003743)1.94694042
97Dysmetria (HP:0001310)1.94452065
98Increased corneal curvature (HP:0100692)1.93409955
99Keratoconus (HP:0000563)1.93409955
100Gowers sign (HP:0003391)1.92576894
101Stridor (HP:0010307)1.90221330
102Abnormal pancreas size (HP:0012094)1.88896704
103Hypoplastic nipples (HP:0002557)1.88832331
104Hyperacusis (HP:0010780)1.87311349
105Rapidly progressive (HP:0003678)1.87072750
106Deep palmar crease (HP:0006191)1.86271003
107Delayed gross motor development (HP:0002194)1.85827607
108Neuroendocrine neoplasm (HP:0100634)1.85347534
109Spastic tetraparesis (HP:0001285)1.85342330
110Spinal rigidity (HP:0003306)1.84087462
111Hemiparesis (HP:0001269)1.83918471
112Open mouth (HP:0000194)1.83688288
113Pelvic girdle muscle weakness (HP:0003749)1.82981536
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.82549421
115Myotonia (HP:0002486)1.82303041
116Stereotypic behavior (HP:0000733)1.81392555
117Aqueductal stenosis (HP:0002410)1.80825772
118Cerebral inclusion bodies (HP:0100314)1.79356499
119Inappropriate behavior (HP:0000719)1.79332727
120Gaze-evoked nystagmus (HP:0000640)1.78523844
121Neoplasm of the peripheral nervous system (HP:0100007)1.77451187
122Abnormality of the labia minora (HP:0012880)1.75984960
123Impaired vibration sensation in the lower limbs (HP:0002166)1.75936917
124Sleep apnea (HP:0010535)1.75171124
125Abnormality of the musculature of the pelvis (HP:0001469)1.74448430
126Abnormality of the hip-girdle musculature (HP:0001445)1.74448430
127Abnormal EKG (HP:0003115)1.73257385
128Hypoplasia of the corpus callosum (HP:0002079)1.72920932
129Anxiety (HP:0000739)1.72650600
130Fetal akinesia sequence (HP:0001989)1.72577046
131Annular pancreas (HP:0001734)1.72111909
132Nephronophthisis (HP:0000090)1.71796473
133Congenital primary aphakia (HP:0007707)1.71670614
134Facial diplegia (HP:0001349)1.70835313
135Bradykinesia (HP:0002067)1.70797562
136Hand muscle atrophy (HP:0009130)1.70710050
137Focal dystonia (HP:0004373)1.70692332
138Pachygyria (HP:0001302)1.69556033
139Polymicrogyria (HP:0002126)1.69539278
140Complete atrioventricular canal defect (HP:0001674)1.69402676
141Generalized hypotonia (HP:0001290)1.69231175
142Abnormality of the astrocytes (HP:0100707)1.69149757
143Astrocytoma (HP:0009592)1.69149757
144Aplasia/Hypoplasia of the lens (HP:0008063)1.69141149
145Clonus (HP:0002169)1.68570044
146Urinary bladder sphincter dysfunction (HP:0002839)1.68357933
147Hypercortisolism (HP:0001578)1.68340626
148Nonprogressive disorder (HP:0003680)1.68130150
149Hemiplegia (HP:0002301)1.68032009
150Epileptiform EEG discharges (HP:0011182)1.67948332
151Akinesia (HP:0002304)1.65748587
152Dysdiadochokinesis (HP:0002075)1.65572057
153EEG with generalized epileptiform discharges (HP:0011198)1.65413082
154Specific learning disability (HP:0001328)1.64037948
155Bundle branch block (HP:0011710)1.63994120
156Atrioventricular canal defect (HP:0006695)1.63447300
157Neoplasm of the heart (HP:0100544)1.63127324
158Nephrogenic diabetes insipidus (HP:0009806)1.61922598
159Ankle contracture (HP:0006466)1.61298008
160Morphological abnormality of the middle ear (HP:0008609)1.61236302
161Type 1 muscle fiber predominance (HP:0003803)1.61220109
162Obstructive sleep apnea (HP:0002870)1.61089997
163Broad ribs (HP:0000885)1.59890681
164Narrow nasal bridge (HP:0000446)1.59329003
165Testicular atrophy (HP:0000029)1.58803823
166Medial flaring of the eyebrow (HP:0010747)1.54653905
167Abnormality of the pulmonary veins (HP:0011718)1.54008971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.18011048
2MARK13.96749079
3NTRK33.36729444
4MAP3K43.31095618
5MINK13.04164367
6AKT33.02538447
7MAP2K72.43631494
8PAK62.32259548
9KSR22.22037407
10ZAK2.11168288
11KSR12.09267684
12TIE12.05380553
13LATS22.00488812
14MAP2K41.96970007
15MAP3K121.94932921
16NTRK11.94842162
17MUSK1.93578722
18PRKD21.91633715
19CAMKK11.85091104
20NTRK21.73223894
21PINK11.70319487
22ARAF1.66868038
23FRK1.63099304
24DAPK21.61458053
25SIK21.58713002
26CAMKK21.58374419
27PRKD31.57761165
28CDK51.51677375
29MYLK1.50941503
30WNK41.47448919
31TLK11.42724445
32EPHA41.41859352
33CASK1.40873714
34DAPK11.39811480
35CAMK1D1.39596308
36SGK21.32864221
37CDK191.29792908
38CDK141.26682439
39SCYL21.26280778
40CDK181.26250608
41RET1.25080286
42TESK21.24238696
43LIMK11.24156208
44GRK51.20473967
45SIK31.19945156
46CDK151.19250370
47STK391.17068354
48DYRK21.15761273
49GRK11.15369125
50FES1.14281000
51TRIB31.13788671
52LMTK21.13463610
53MAPK131.12277848
54PHKG21.11882499
55PHKG11.11882499
56TESK11.11324266
57FLT31.08736814
58SGK31.06048264
59CCNB11.03215081
60TNIK1.02733744
61CDK11A1.02416138
62TAOK11.02323463
63NUAK11.02259607
64UHMK11.02206877
65PRKCG1.00804171
66ALK1.00048713
67RIPK40.99220983
68PAK30.98534080
69WNK30.97897143
70LATS10.96449844
71PAK20.94741543
72MAP3K60.94458786
73NEK10.93319771
74ICK0.93083069
75PLK20.93070298
76PRKAA10.90922634
77OXSR10.87478847
78RIPK10.81940015
79PTK2B0.81740966
80STK380.81715737
81EEF2K0.81267891
82PRKCE0.78833033
83TYRO30.77907129
84CSNK1G20.77048917
85TAOK20.75090620
86MAPKAPK50.74829575
87PNCK0.74702705
88DMPK0.72415639
89FER0.72350357
90BRAF0.72303256
91PRPF4B0.70239855
92RPS6KA20.70162852
93ADRBK20.68857246
94CSNK1A1L0.67025685
95PIK3CG0.64564028
96SGK2230.64060824
97SGK4940.64060824
98WNK10.62924671
99MAP3K20.62831981
100ADRBK10.62265653
101TSSK60.61430926
102DYRK1A0.60780446
103PKN20.60683940
104RAF10.59309589
105CAMK10.58439400
106CSNK1G10.58205309
107DYRK1B0.57968135
108ILK0.55851840
109DAPK30.55670802
110MAP3K10.55384100
111STK110.55147218
112CAMK2B0.54893684
113TNK20.54442315
114EPHB20.53534912
115CSNK1G30.53467001
116FYN0.52348784
117PRKCZ0.51337777
118PDK10.50830016
119CAMK1G0.50002931
120RPS6KA60.49800237
121MAP2K10.49740861
122PDPK10.48465634
123MAPK120.48385144
124CAMK2A0.47308615
125BCR0.47230453
126PRKCH0.46318365
127HIPK20.45635467
128PTK20.44732432
129MAP3K130.44505723
130PDK40.44146194
131PDK30.44146194
132BRSK10.44001341
133* MARK20.43093171
134MAPK100.42749454
135CAMK40.40268022
136MAP2K60.40209261
137PRKAA20.39864298
138MAPK90.38229627
139NME10.35942987
140ROCK20.35530885
141PRKCI0.31753844
142ERBB30.31604838
143PAK10.31171882

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.23991804
2Olfactory transduction_Homo sapiens_hsa047402.51133068
3Nicotine addiction_Homo sapiens_hsa050332.47995077
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20112763
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00202598
6Long-term potentiation_Homo sapiens_hsa047201.96873146
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96509459
8GABAergic synapse_Homo sapiens_hsa047271.88153420
9Circadian entrainment_Homo sapiens_hsa047131.86808503
10Dopaminergic synapse_Homo sapiens_hsa047281.80440658
11Selenocompound metabolism_Homo sapiens_hsa004501.79836195
12Morphine addiction_Homo sapiens_hsa050321.77978137
13Glutamatergic synapse_Homo sapiens_hsa047241.69380309
14Insulin secretion_Homo sapiens_hsa049111.64726191
15Collecting duct acid secretion_Homo sapiens_hsa049661.63669415
16Cholinergic synapse_Homo sapiens_hsa047251.58430629
17Amphetamine addiction_Homo sapiens_hsa050311.53842495
18Vibrio cholerae infection_Homo sapiens_hsa051101.46720803
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45084961
20Salivary secretion_Homo sapiens_hsa049701.43440284
21Gap junction_Homo sapiens_hsa045401.39407634
22Gastric acid secretion_Homo sapiens_hsa049711.38555877
23GnRH signaling pathway_Homo sapiens_hsa049121.36048598
24Taste transduction_Homo sapiens_hsa047421.35412271
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32843463
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32381925
27Oxytocin signaling pathway_Homo sapiens_hsa049211.31309736
28Circadian rhythm_Homo sapiens_hsa047101.29910930
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.29800104
30Oocyte meiosis_Homo sapiens_hsa041141.29085085
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28131474
32Glioma_Homo sapiens_hsa052141.28036866
33Long-term depression_Homo sapiens_hsa047301.27909224
34Estrogen signaling pathway_Homo sapiens_hsa049151.21523024
35Axon guidance_Homo sapiens_hsa043601.20640128
36Renin secretion_Homo sapiens_hsa049241.19057201
37ErbB signaling pathway_Homo sapiens_hsa040121.15711957
38Cocaine addiction_Homo sapiens_hsa050301.12914715
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12805911
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10007553
41Serotonergic synapse_Homo sapiens_hsa047261.09369150
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07918222
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05941521
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05625083
45Type II diabetes mellitus_Homo sapiens_hsa049301.03651046
46VEGF signaling pathway_Homo sapiens_hsa043701.02662421
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02063863
48Vitamin B6 metabolism_Homo sapiens_hsa007501.00441353
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00135449
50* Endocytosis_Homo sapiens_hsa041440.98750464
51Calcium signaling pathway_Homo sapiens_hsa040200.98615486
52Renal cell carcinoma_Homo sapiens_hsa052110.95470418
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92195573
54mTOR signaling pathway_Homo sapiens_hsa041500.90256892
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.90250903
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89651948
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88754072
58Colorectal cancer_Homo sapiens_hsa052100.88219158
59cAMP signaling pathway_Homo sapiens_hsa040240.87891042
60Melanogenesis_Homo sapiens_hsa049160.87589313
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86919201
62Focal adhesion_Homo sapiens_hsa045100.85806544
63MAPK signaling pathway_Homo sapiens_hsa040100.84655561
64AMPK signaling pathway_Homo sapiens_hsa041520.82602338
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81882019
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81353840
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80854593
68Endometrial cancer_Homo sapiens_hsa052130.80717964
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80682193
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80653223
71Hedgehog signaling pathway_Homo sapiens_hsa043400.80599470
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80059489
73Phagosome_Homo sapiens_hsa041450.79714918
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78977877
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77725649
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76612354
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76592875
78Glucagon signaling pathway_Homo sapiens_hsa049220.74193647
79Alcoholism_Homo sapiens_hsa050340.74015259
80Rap1 signaling pathway_Homo sapiens_hsa040150.73785372
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73435874
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72787005
83Non-small cell lung cancer_Homo sapiens_hsa052230.72253032
84Choline metabolism in cancer_Homo sapiens_hsa052310.67578488
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66865054
86Melanoma_Homo sapiens_hsa052180.66821176
87Ras signaling pathway_Homo sapiens_hsa040140.65922461
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.65286324
89Salmonella infection_Homo sapiens_hsa051320.64831422
90Proteoglycans in cancer_Homo sapiens_hsa052050.64612926
91Shigellosis_Homo sapiens_hsa051310.64388336
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64081390
93Dorso-ventral axis formation_Homo sapiens_hsa043200.63985718
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63673611
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62644123
96RNA polymerase_Homo sapiens_hsa030200.62414215
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.62296622
98Tight junction_Homo sapiens_hsa045300.60466972
99Insulin signaling pathway_Homo sapiens_hsa049100.60418402
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60374795
101Dilated cardiomyopathy_Homo sapiens_hsa054140.58991408
102Ovarian steroidogenesis_Homo sapiens_hsa049130.58913405
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58636965
104FoxO signaling pathway_Homo sapiens_hsa040680.57814731
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57604204
106ECM-receptor interaction_Homo sapiens_hsa045120.57526626
107Lysosome_Homo sapiens_hsa041420.56403581
108Cardiac muscle contraction_Homo sapiens_hsa042600.56023260
109Prolactin signaling pathway_Homo sapiens_hsa049170.55254651
110Phototransduction_Homo sapiens_hsa047440.54493014
111Basal cell carcinoma_Homo sapiens_hsa052170.53770180
112Chronic myeloid leukemia_Homo sapiens_hsa052200.53652821
113Thyroid hormone synthesis_Homo sapiens_hsa049180.52719695
114Pancreatic secretion_Homo sapiens_hsa049720.52673152
115Inositol phosphate metabolism_Homo sapiens_hsa005620.51046036
116Regulation of autophagy_Homo sapiens_hsa041400.49745276
117B cell receptor signaling pathway_Homo sapiens_hsa046620.48706344
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46877766
119N-Glycan biosynthesis_Homo sapiens_hsa005100.45755623
120Wnt signaling pathway_Homo sapiens_hsa043100.45001659
121Hippo signaling pathway_Homo sapiens_hsa043900.44882112
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44198410
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42844825
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42605897

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