RNF31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.21000263
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.15861168
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.15861168
4antigen processing and presentation of endogenous antigen (GO:0019883)5.80913680
5regulation of gamma-delta T cell activation (GO:0046643)4.78067181
6regulation of gamma-delta T cell differentiation (GO:0045586)4.73286715
7response to type I interferon (GO:0034340)4.44360031
8regulation of interleukin-12 biosynthetic process (GO:0045075)4.41068035
9cellular response to type I interferon (GO:0071357)4.38286100
10type I interferon signaling pathway (GO:0060337)4.38286100
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36587101
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.36587101
13modulation by symbiont of host immune response (GO:0052553)4.36587101
14positive regulation by symbiont of host defense response (GO:0052509)4.36587101
15modulation by symbiont of host defense response (GO:0052031)4.36587101
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36587101
17negative regulation of erythrocyte differentiation (GO:0045647)4.31024339
18NIK/NF-kappaB signaling (GO:0038061)4.26832404
19positive regulation of interferon-alpha production (GO:0032727)4.26240070
20positive thymic T cell selection (GO:0045059)4.25377632
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.24278261
22detection of bacterium (GO:0016045)4.16851487
23detection of other organism (GO:0098543)4.15518907
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14557834
25regulation of interferon-alpha production (GO:0032647)4.07602874
26T cell migration (GO:0072678)4.00348715
27regulation of type I interferon-mediated signaling pathway (GO:0060338)3.89753476
28regulation of interferon-beta biosynthetic process (GO:0045357)3.84831770
29interferon-gamma-mediated signaling pathway (GO:0060333)3.75826973
30immunoglobulin mediated immune response (GO:0016064)3.70013704
31negative thymic T cell selection (GO:0045060)3.64079913
32negative regulation of cell killing (GO:0031342)3.64060375
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64060375
34negative T cell selection (GO:0043383)3.56952989
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55708898
36regulation of B cell receptor signaling pathway (GO:0050855)3.50096053
37positive regulation of interferon-beta production (GO:0032728)3.50047915
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49543196
39detection of external biotic stimulus (GO:0098581)3.48210266
40leukocyte aggregation (GO:0070486)3.40948205
41macrophage activation involved in immune response (GO:0002281)3.39156706
42thymic T cell selection (GO:0045061)3.36392824
43JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.36229949
44positive T cell selection (GO:0043368)3.35133930
45negative regulation of interleukin-12 production (GO:0032695)3.32671385
46regulation of response to interferon-gamma (GO:0060330)3.32231139
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.32080230
48cellular response to virus (GO:0098586)3.30320410
49response to host immune response (GO:0052572)3.25231797
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25231797
51response to muramyl dipeptide (GO:0032495)3.22148313
52regulation of T-helper 2 cell differentiation (GO:0045628)3.22117550
53T cell selection (GO:0045058)3.20428034
54response to interferon-alpha (GO:0035455)3.16625250
55positive regulation of antigen processing and presentation (GO:0002579)3.15060785
56regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.13292234
57response to peptidoglycan (GO:0032494)3.13155058
58positive regulation of humoral immune response (GO:0002922)3.11215670
59cellular extravasation (GO:0045123)3.10685201
60regulation of alpha-beta T cell proliferation (GO:0046640)3.08396408
61detection of biotic stimulus (GO:0009595)3.06870232
62detection of molecule of bacterial origin (GO:0032490)3.06269464
63mannose metabolic process (GO:0006013)3.06201924
64cellular response to interferon-beta (GO:0035458)3.06141900
65B cell mediated immunity (GO:0019724)3.05072171
66positive regulation of B cell differentiation (GO:0045579)3.04281341
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.03934330
68I-kappaB phosphorylation (GO:0007252)3.03159437
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02709888
70response to host (GO:0075136)3.02709888
71response to host defenses (GO:0052200)3.02709888
72antigen processing and presentation via MHC class Ib (GO:0002475)2.99836555
73B cell receptor signaling pathway (GO:0050853)2.99828451
74negative regulation of T cell mediated immunity (GO:0002710)2.98478361
75negative regulation of innate immune response (GO:0045824)2.97111479
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96982642
77interferon-gamma production (GO:0032609)2.95766302
78neutrophil activation involved in immune response (GO:0002283)2.95730426
79negative regulation of cytokine production involved in immune response (GO:0002719)2.95560763
80negative regulation of viral release from host cell (GO:1902187)2.95407306
81cellular response to zinc ion (GO:0071294)2.94367035
82cellular response to interferon-gamma (GO:0071346)2.93424359
83pinocytosis (GO:0006907)2.92594654
84negative regulation of leukocyte mediated immunity (GO:0002704)2.92346109
85defense response to protozoan (GO:0042832)2.92263988
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88890566
87myeloid dendritic cell activation (GO:0001773)2.88428249
88modulation by symbiont of host cellular process (GO:0044068)2.88074646
89leukocyte cell-cell adhesion (GO:0007159)2.87479421
90natural killer cell differentiation (GO:0001779)2.87458016
91mature B cell differentiation (GO:0002335)2.86952976
92regulation of interferon-beta production (GO:0032648)2.85408789
93regulation of B cell differentiation (GO:0045577)2.84508922
94negative regulation of viral genome replication (GO:0045071)2.84362669
95tolerance induction (GO:0002507)2.83717573
96myeloid dendritic cell differentiation (GO:0043011)2.83428636
97regulation of leukocyte degranulation (GO:0043300)2.82853453
98positive regulation of natural killer cell differentiation (GO:0032825)2.81353677
99regulation of RIG-I signaling pathway (GO:0039535)2.80151342
100embryonic process involved in female pregnancy (GO:0060136)2.79293924
101negative regulation of type 2 immune response (GO:0002829)2.79244838
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79190417
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77832136
104germinal center formation (GO:0002467)2.77564876
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.76300836
106response to interleukin-15 (GO:0070672)2.74668071
107regulation of mast cell degranulation (GO:0043304)2.72064125
108respiratory burst (GO:0045730)2.71380432
109response to protozoan (GO:0001562)2.70626436
110regulation of integrin activation (GO:0033623)2.68664850
111cellular response to exogenous dsRNA (GO:0071360)2.68610722
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.67892331
113lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67164171
114modulation by virus of host process (GO:0019054)2.64896640
115positive regulation of immunoglobulin mediated immune response (GO:0002891)2.64473704
116positive regulation of B cell mediated immunity (GO:0002714)2.64473704
117negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63871429
118response to interferon-beta (GO:0035456)2.63862550
119positive regulation of isotype switching (GO:0045830)2.63349233
120regulation of interleukin-12 production (GO:0032655)2.61358277
121regulation of T cell tolerance induction (GO:0002664)2.60952050
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60563141
1233-UTR-mediated mRNA stabilization (GO:0070935)2.60511630
124regulation of antigen processing and presentation (GO:0002577)2.59985917
125positive regulation of histone deacetylation (GO:0031065)2.59665378
126regulation of type 2 immune response (GO:0002828)2.57297198
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57019153
128positive regulation of type 2 immune response (GO:0002830)2.55988851
129positive regulation of cytokine biosynthetic process (GO:0042108)2.54987460
130myeloid cell activation involved in immune response (GO:0002275)2.52963574
131natural killer cell activation (GO:0030101)2.50469761
132regulation of T cell receptor signaling pathway (GO:0050856)2.49848423
133regulation of T-helper 1 cell differentiation (GO:0045625)2.49661682
134apoptotic process involved in morphogenesis (GO:0060561)2.46191294
135regulation of necroptotic process (GO:0060544)2.45775253
136CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.45722354
137regulation of tolerance induction (GO:0002643)2.45473487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22253456
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88166767
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.88043100
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.79940788
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.78562598
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60729069
7* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46909573
8E2F7_22180533_ChIP-Seq_HELA_Human3.27327771
9MYC_22102868_ChIP-Seq_BL_Human3.14539837
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88927674
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88692835
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.71914345
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.70481188
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58414060
15VDR_21846776_ChIP-Seq_THP-1_Human2.56648547
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55718551
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.51885762
18MAF_26560356_Chip-Seq_TH1_Human2.39884241
19* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37519011
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36483006
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35386533
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27710499
23SCL_19346495_ChIP-Seq_HPC-7_Human2.23476632
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20318404
25UTX_26944678_Chip-Seq_JUKART_Human2.12262069
26MYB_26560356_Chip-Seq_TH2_Human2.12033235
27GATA1_22025678_ChIP-Seq_K562_Human2.11187202
28TCF7_22412390_ChIP-Seq_EML_Mouse2.10544800
29MYB_26560356_Chip-Seq_TH1_Human2.09306568
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03018072
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00248558
32RUNX_20019798_ChIP-Seq_JUKART_Human1.94625372
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89851408
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89383328
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88757048
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81484917
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.79083504
38KDM2B_26808549_Chip-Seq_DND41_Human1.77943740
39SPI1_23547873_ChIP-Seq_NB4_Human1.77562389
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77374305
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77187530
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77097548
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76360562
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76167812
45VDR_24763502_ChIP-Seq_THP-1_Human1.73505623
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70719067
47SPI1_23127762_ChIP-Seq_K562_Human1.68766006
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.65736131
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63038167
50KDM2B_26808549_Chip-Seq_K562_Human1.57055902
51MAF_26560356_Chip-Seq_TH2_Human1.56357451
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.56042317
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52241430
54P68_20966046_ChIP-Seq_HELA_Human1.40734790
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.40609741
56CIITA_25753668_ChIP-Seq_RAJI_Human1.39787572
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.38776249
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36219048
59* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35142605
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33664978
61SMC4_20622854_ChIP-Seq_HELA_Human1.33051652
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31822493
63* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30658201
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29955895
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28943878
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28218237
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27702959
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27133803
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26160759
70GATA3_27048872_Chip-Seq_THYMUS_Human1.26023757
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25610886
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23049458
73ZNF263_19887448_ChIP-Seq_K562_Human1.22138287
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20312915
75PU_27001747_Chip-Seq_BMDM_Mouse1.20075374
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.19277821
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17039584
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14885481
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14609085
80CREB1_26743006_Chip-Seq_LNCaP_Human1.12661182
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12514928
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11671435
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11205098
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10729900
85LXR_22292898_ChIP-Seq_THP-1_Human1.10171879
86NCOR1_26117541_ChIP-Seq_K562_Human1.10171850
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10084687
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08739103
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.07280237
90* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05725558
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04765449
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04634069
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.04048784
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03491038
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02250455
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02108990
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01464335
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.00952133
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99961458
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99203321
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98987558
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98263907
103RXR_22158963_ChIP-Seq_LIVER_Mouse0.98048689
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98029570
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.94855587
106TFEB_21752829_ChIP-Seq_HELA_Human0.92862454
107RACK7_27058665_Chip-Seq_MCF-7_Human0.92198895
108GATA3_26560356_Chip-Seq_TH2_Human0.90723235
109GATA1_19941826_ChIP-Seq_K562_Human0.90638814
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88318348
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84653808
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83823057
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83217596
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82634041
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82059376
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81663224
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80868366
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80769941
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78350982
120BCL6_27268052_Chip-Seq_Bcells_Human0.77424569
121SPI1_20517297_ChIP-Seq_HL60_Human0.77407491
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.77393474
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75901136
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.75827923
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75129043
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73261047
127BCOR_27268052_Chip-Seq_Bcells_Human0.72867054
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72838601
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72703120
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72391983
131GATA2_19941826_ChIP-Seq_K562_Human0.72286695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.83196795
2MP0005451_abnormal_body_composition3.34852624
3MP0000685_abnormal_immune_system3.19715093
4MP0003303_peritoneal_inflammation3.03599453
5MP0001790_abnormal_immune_system3.02636584
6MP0005387_immune_system_phenotype3.02636584
7MP0003436_decreased_susceptibility_to2.92676221
8MP0001800_abnormal_humoral_immune2.88364236
9MP0005671_abnormal_response_to2.86923268
10MP0004510_myositis2.81905913
11MP0009785_altered_susceptibility_to2.75973454
12MP0003763_abnormal_thymus_physiology2.60248769
13MP0005000_abnormal_immune_tolerance2.58212984
14MP0008260_abnormal_autophagy2.53478746
15MP0005025_abnormal_response_to2.52409888
16MP0002452_abnormal_antigen_presenting2.50736060
17MP0002723_abnormal_immune_serum2.42745997
18MP0003724_increased_susceptibility_to2.34593488
19MP0002166_altered_tumor_susceptibility2.30451650
20MP0001819_abnormal_immune_cell2.30016403
21MP0006082_CNS_inflammation2.29880104
22MP0002420_abnormal_adaptive_immunity2.28448108
23MP0009278_abnormal_bone_marrow2.22440007
24MP0002419_abnormal_innate_immunity2.20486660
25MP0002398_abnormal_bone_marrow2.20477278
26MP0002148_abnormal_hypersensitivity_rea2.13168818
27MP0002396_abnormal_hematopoietic_system2.09078363
28MP0003300_gastrointestinal_ulcer2.07100539
29MP0004947_skin_inflammation2.07066039
30MP0000716_abnormal_immune_system1.99183768
31MP0010155_abnormal_intestine_physiology1.92783236
32MP0002405_respiratory_system_inflammati1.90725425
33MP0002006_tumorigenesis1.86382998
34MP0001545_abnormal_hematopoietic_system1.83542281
35MP0005397_hematopoietic_system_phenotyp1.83542281
36MP0005464_abnormal_platelet_physiology1.83324375
37MP0000689_abnormal_spleen_morphology1.77997412
38MP0001853_heart_inflammation1.77088806
39MP0010352_gastrointestinal_tract_polyps1.76530927
40MP0002722_abnormal_immune_system1.72072801
41MP0009333_abnormal_splenocyte_physiolog1.69560118
42MP0002429_abnormal_blood_cell1.68753793
43MP0004808_abnormal_hematopoietic_stem1.68041115
44MP0001845_abnormal_inflammatory_respons1.67660022
45MP0001873_stomach_inflammation1.67379254
46MP0005310_abnormal_salivary_gland1.61356600
47MP0009840_abnormal_foam_cell1.55186985
48MP0000703_abnormal_thymus_morphology1.54470357
49MP0005076_abnormal_cell_differentiation1.50319041
50MP0003172_abnormal_lysosome_physiology1.49438476
51MP0003191_abnormal_cellular_cholesterol1.44983302
52MP0003866_abnormal_defecation1.40196168
53MP0004381_abnormal_hair_follicle1.40133436
54MP0001533_abnormal_skeleton_physiology1.39958268
55MP0008469_abnormal_protein_level1.33613081
56MP0004858_abnormal_nervous_system1.29133738
57MP0010307_abnormal_tumor_latency1.27347471
58MP0001849_ear_inflammation1.25055600
59MP0004185_abnormal_adipocyte_glucose1.24031099
60MP0005058_abnormal_lysosome_morphology1.22949705
61MP0003448_altered_tumor_morphology1.21369628
62MP0000569_abnormal_digit_pigmentation1.18441673
63MP0003566_abnormal_cell_adhesion1.16359046
64MP0000490_abnormal_crypts_of1.09030249
65MP0001348_abnormal_lacrimal_gland1.06953771
66MP0003828_pulmonary_edema1.02915533
67MP0002138_abnormal_hepatobiliary_system1.02151923
68MP0000858_altered_metastatic_potential1.01122872
69MP0002132_abnormal_respiratory_system1.00704911
70MP0005666_abnormal_adipose_tissue0.99736853
71MP0009764_decreased_sensitivity_to0.99238392
72MP0002933_joint_inflammation0.99004495
73MP0008961_abnormal_basal_metabolism0.97700302
74MP0005023_abnormal_wound_healing0.96540529
75MP0003183_abnormal_peptide_metabolism0.94860702
76MP0003705_abnormal_hypodermis_morpholog0.94823857
77MP0000343_altered_response_to0.92686432
78MP0009763_increased_sensitivity_to0.91015748
79MP0005409_darkened_coat_color0.90617968
80MP0000371_diluted_coat_color0.88247382
81MP0002019_abnormal_tumor_incidence0.88201496
82MP0008057_abnormal_DNA_replication0.86899731
83MP0001663_abnormal_digestive_system0.85097772
84MP0005390_skeleton_phenotype0.85068923
85MP0000609_abnormal_liver_physiology0.84739618
86MP0003045_fibrosis0.83485529
87MP0002254_reproductive_system_inflammat0.82223628
88MP0000465_gastrointestinal_hemorrhage0.81893089
89MP0002998_abnormal_bone_remodeling0.79639889
90MP0004264_abnormal_extraembryonic_tissu0.79619583
91MP0004883_abnormal_blood_vessel0.78321909
92MP0003091_abnormal_cell_migration0.77754132
93MP0003329_amyloid_beta_deposits0.77587439
94MP0003690_abnormal_glial_cell0.77549010
95MP0003077_abnormal_cell_cycle0.76999291
96MP0003453_abnormal_keratinocyte_physiol0.76742021
97MP0001851_eye_inflammation0.76418078
98MP0002089_abnormal_postnatal_growth/wei0.75414972
99MP0003075_altered_response_to0.75065272
100MP0005670_abnormal_white_adipose0.73750435
101MP0000678_abnormal_parathyroid_gland0.72574132
102MP0003693_abnormal_embryo_hatching0.70412904
103MP0005375_adipose_tissue_phenotype0.70301697
104MP0003111_abnormal_nucleus_morphology0.66941456
105MP0005166_decreased_susceptibility_to0.65866914
106MP0000598_abnormal_liver_morphology0.65557924
107MP0005621_abnormal_cell_physiology0.65386464
108MP0005174_abnormal_tail_pigmentation0.64906174
109MP0010094_abnormal_chromosome_stability0.64839229
110MP0000249_abnormal_blood_vessel0.64025498
111MP0000313_abnormal_cell_death0.63656159
112MP0008874_decreased_physiological_sensi0.62821074
113MP0003279_aneurysm0.62477166
114MP0002877_abnormal_melanocyte_morpholog0.62360282
115MP0009931_abnormal_skin_appearance0.62321433
116MP0002136_abnormal_kidney_physiology0.62087906
117MP0003943_abnormal_hepatobiliary_system0.60138271
118MP0000767_abnormal_smooth_muscle0.59597020
119MP0001915_intracranial_hemorrhage0.59561386
120MP0000604_amyloidosis0.57525048
121MP0005083_abnormal_biliary_tract0.56509827
122MP0002277_abnormal_respiratory_mucosa0.54659946

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.89839089
2Autoimmune thrombocytopenia (HP:0001973)4.56505659
3Recurrent abscess formation (HP:0002722)4.45502369
4Recurrent viral infections (HP:0004429)4.38263530
5Recurrent fungal infections (HP:0002841)4.28779884
6Chronic otitis media (HP:0000389)4.19757945
7Recurrent bacterial skin infections (HP:0005406)3.93686984
8Elevated erythrocyte sedimentation rate (HP:0003565)3.89125310
9Abnormality of the fingertips (HP:0001211)3.64423694
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.56593008
11Mediastinal lymphadenopathy (HP:0100721)3.53659455
12Myositis (HP:0100614)3.52873189
13Pustule (HP:0200039)3.34904003
14Recurrent bronchitis (HP:0002837)3.32004152
15Nasal polyposis (HP:0100582)3.27828568
16Recurrent gram-negative bacterial infections (HP:0005420)3.26055866
17Increased IgE level (HP:0003212)3.19905483
18Colitis (HP:0002583)3.18511397
19Vasculitis (HP:0002633)3.18405055
20Chronic mucocutaneous candidiasis (HP:0002728)3.14208093
21Recurrent cutaneous fungal infections (HP:0011370)3.14208093
22Panhypogammaglobulinemia (HP:0003139)3.10215100
23Abnormality of the nasal mucosa (HP:0000433)3.05740676
24Abnormality of T cell number (HP:0011839)3.03050169
25IgM deficiency (HP:0002850)3.02279377
26T lymphocytopenia (HP:0005403)2.98427736
27Deep venous thrombosis (HP:0002625)2.95556386
28Orchitis (HP:0100796)2.92850320
29Abnormality of T cells (HP:0002843)2.91070101
30Cellulitis (HP:0100658)2.88454420
31Recurrent skin infections (HP:0001581)2.88291968
32Abnormality of macrophages (HP:0004311)2.87369061
33Gastrointestinal inflammation (HP:0004386)2.85168168
34Inflammation of the large intestine (HP:0002037)2.83631256
35Stomatitis (HP:0010280)2.73882707
36Abnormality of T cell physiology (HP:0011840)2.72614963
37Periodontitis (HP:0000704)2.72128793
38Gingivitis (HP:0000230)2.68554879
39Emphysema (HP:0002097)2.68140976
40Optic neuritis (HP:0100653)2.66686278
41Retrobulbar optic neuritis (HP:0100654)2.66686278
42Meningitis (HP:0001287)2.61865071
43Eosinophilia (HP:0001880)2.61671124
44Pulmonary infiltrates (HP:0002113)2.59819538
45Interstitial pulmonary disease (HP:0006530)2.59456851
46Spontaneous hematomas (HP:0007420)2.56306798
47Arterial thrombosis (HP:0004420)2.55720275
48Leukocytosis (HP:0001974)2.55578272
49Lymphopenia (HP:0001888)2.54448091
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.52612609
51Hemorrhage of the eye (HP:0011885)2.50618741
52Agammaglobulinemia (HP:0004432)2.47911848
53Chronic diarrhea (HP:0002028)2.44214602
54Loss of speech (HP:0002371)2.38787620
55IgA deficiency (HP:0002720)2.38753927
56Granulocytopenia (HP:0001913)2.38055690
57Systemic lupus erythematosus (HP:0002725)2.34003614
58Hypergammaglobulinemia (HP:0010702)2.33939512
59Gingival bleeding (HP:0000225)2.32510836
60Chronic sinusitis (HP:0011109)2.32382379
61Hemoptysis (HP:0002105)2.29023157
62Gastrointestinal stroma tumor (HP:0100723)2.28876229
63Combined immunodeficiency (HP:0005387)2.26078580
64Obstructive lung disease (HP:0006536)2.24480973
65Chronic obstructive pulmonary disease (HP:0006510)2.24480973
66Thrombocytosis (HP:0001894)2.24211808
67Abnormality of B cell number (HP:0010975)2.21801657
68B lymphocytopenia (HP:0010976)2.21801657
69Hypochromic anemia (HP:0001931)2.21683223
70Increased IgM level (HP:0003496)2.21011588
71Autoimmune hemolytic anemia (HP:0001890)2.20875058
72Broad face (HP:0000283)2.20641442
73Severe combined immunodeficiency (HP:0004430)2.18390588
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17763147
75Chest pain (HP:0100749)2.16568335
76Abnormality of eosinophils (HP:0001879)2.15413908
77Thin bony cortex (HP:0002753)2.14317641
78Petechiae (HP:0000967)2.13532821
79Dysostosis multiplex (HP:0000943)2.12840874
80Osteomyelitis (HP:0002754)2.11984352
81Obstructive sleep apnea (HP:0002870)2.11026628
82Increased cerebral lipofuscin (HP:0011813)2.10446948
83Prolonged bleeding time (HP:0003010)2.10373791
84Epistaxis (HP:0000421)2.07753142
85Purpura (HP:0000979)2.07614319
86Cerebral aneurysm (HP:0004944)2.07076807
87Basal ganglia calcification (HP:0002135)2.06390866
88Polygenic inheritance (HP:0010982)2.06222443
89Increased connective tissue (HP:0009025)2.03584928
90Keratoconjunctivitis sicca (HP:0001097)2.03161237
91Abnormality of the peritoneum (HP:0002585)2.02721423
92IgG deficiency (HP:0004315)2.01395520
93Amyloidosis (HP:0011034)2.01305119
94Joint swelling (HP:0001386)2.01110314
95Encephalitis (HP:0002383)2.01079668
96Gastrointestinal infarctions (HP:0005244)2.00666884
97Peritonitis (HP:0002586)2.00226337
98Pulmonary embolism (HP:0002204)2.00218983
99Segmental peripheral demyelination/remyelination (HP:0003481)2.00078511
100Thyroiditis (HP:0100646)1.99673963
101Flat acetabular roof (HP:0003180)1.99155895
102Skin ulcer (HP:0200042)1.98455662
103Thoracic kyphosis (HP:0002942)1.97240846
104Abnormality of the thoracic spine (HP:0100711)1.96989084
105Myopathic facies (HP:0002058)1.96268442
106Cheilitis (HP:0100825)1.96069265
107Metaphyseal cupping (HP:0003021)1.95394798
108Increased serum ferritin (HP:0003281)1.94924036
109Centrally nucleated skeletal muscle fibers (HP:0003687)1.94229405
110Frequent falls (HP:0002359)1.94154758
111Abnormality of liposaccharide metabolism (HP:0010968)1.93575872
112Abnormality of glycosphingolipid metabolism (HP:0004343)1.93575872
113Abnormality of glycolipid metabolism (HP:0010969)1.93575872
114Hematochezia (HP:0002573)1.93217162
115Abnormal platelet volume (HP:0011876)1.93015619
116Leukopenia (HP:0001882)1.91414218
117Porencephaly (HP:0002132)1.90444690
118Hyperacusis (HP:0010780)1.88324904
119Keratoconjunctivitis (HP:0001096)1.87344036
120Papilloma (HP:0012740)1.86256932
121Verrucae (HP:0200043)1.86256932
122Abnormality of the endocardium (HP:0004306)1.85896658
123Lymphoma (HP:0002665)1.85824208
124Myocardial infarction (HP:0001658)1.83972775
125Urticaria (HP:0001025)1.83580377
126Long eyelashes (HP:0000527)1.83000991
127Persistence of primary teeth (HP:0006335)1.82235794
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.81757742
129Restrictive lung disease (HP:0002091)1.78387120
130Hypertriglyceridemia (HP:0002155)1.76929793
131Easy fatigability (HP:0003388)1.75754455
132Viral hepatitis (HP:0006562)1.73119139
133Episodic fever (HP:0001954)1.73098687
134Aneurysm (HP:0002617)1.72017403
135Glomerulopathy (HP:0100820)1.71517710
136Distal lower limb amyotrophy (HP:0008944)1.71195989
137Slow saccadic eye movements (HP:0000514)1.69399605
138Joint hemorrhage (HP:0005261)1.68811956
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67473078
140Abnormality of polysaccharide metabolism (HP:0011012)1.67473078
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67473078
142Glomerulonephritis (HP:0000099)1.66277362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.20234594
2TYK23.36146540
3PRPF4B3.06958136
4MAP3K143.02136015
5ERN12.82452903
6SMG12.79085939
7IKBKE2.74875809
8CDK122.74161956
9JAK32.67649065
10TBK12.60828696
11MAP3K102.51833316
12TXK2.48004635
13JAK12.47046992
14FGFR42.21210528
15ICK2.05461008
16ZAP702.00171956
17IRAK41.96919428
18MAP3K131.94160350
19KIT1.86598211
20PKN21.84861881
21GRK61.82594933
22TRIB31.69720858
23EEF2K1.64841569
24STK101.61601778
25IKBKB1.59137392
26BRD41.59092679
27CSK1.56146038
28SIK21.50289379
29BLK1.48916397
30CHUK1.45345600
31BTK1.37814234
32TGFBR21.34521819
33IRAK31.34357795
34HCK1.33321446
35ITK1.29141043
36SYK1.28788649
37MARK21.27963930
38TTN1.26836241
39RIPK11.26163095
40EPHB11.25415891
41CDC42BPA1.24064412
42PTK61.23335177
43MAP3K11.23181999
44CSF1R1.21777468
45FGFR31.21486449
46MAP2K31.17964687
47RIPK41.17697056
48NLK1.17068283
49JAK21.11004308
50LCK1.09596621
51TAOK21.07212966
52KSR21.07030125
53PIM11.05280678
54PRKD21.03631654
55RPS6KA40.98945016
56TAOK30.96698366
57SIK10.95203034
58MARK30.95021495
59NEK90.91460719
60PDPK10.89819805
61MAP3K60.88879406
62SIK30.87314568
63LRRK20.86664608
64MAP3K70.85968571
65ALK0.85244951
66TYRO30.82796291
67CLK10.81985568
68CAMK1D0.81046324
69CDK40.79477272
70TEC0.79152418
71FLT30.78976153
72RPS6KA20.77176258
73STK40.75468286
74EPHA30.75374885
75PDK10.74784836
76PDGFRA0.74483876
77LYN0.73329252
78DYRK1B0.71928960
79MATK0.71369944
80KDR0.70991649
81TAOK10.66628805
82MAP2K20.65192090
83RET0.64754720
84BMX0.63288514
85MAPK120.61042057
86PRKCH0.61022963
87MAPK110.59175134
88IRAK20.58916548
89MAP3K110.58754065
90TGFBR10.55944690
91HIPK20.52197251
92TESK20.51244910
93CAMK1G0.50619588
94MAPK70.50033724
95MTOR0.49655970
96SGK30.49109760
97TNK20.48935811
98ATR0.48798381
99DDR20.48296736
100NEK20.47394479
101RPS6KA60.47293736
102MAP3K50.46447128
103FGR0.46250984
104RPS6KB20.45762321
105PAK40.45275782
106TRPM70.44852927
107TSSK60.43360053
108PRKG20.41402215
109FES0.40371298
110CDK60.39325685
111PIM20.38976112
112DMPK0.38827362
113FYN0.38477376
114MAP3K80.38359054
115IRAK10.36919651
116EGFR0.36650245
117CDK90.36526497
118RPS6KC10.36051919
119RPS6KL10.36051919
120ABL10.35001143
121EPHA20.34875516
122NME20.34725535
123MAPK40.34116004
124MELK0.33654008
125PDGFRB0.32803411
126PRKCQ0.32659667
127MAP3K20.31679018
128CAMK40.31303236
129MAPKAPK20.30938700
130MAP3K30.30364845
131RPS6KA50.27119527
132RPS6KA10.26999556

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.97281093
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.86864447
3Leishmaniasis_Homo sapiens_hsa051402.78219828
4Measles_Homo sapiens_hsa051622.57485202
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43008293
6Osteoclast differentiation_Homo sapiens_hsa043802.31521522
7B cell receptor signaling pathway_Homo sapiens_hsa046622.30648809
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27453170
9Herpes simplex infection_Homo sapiens_hsa051682.16514261
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13449067
11Influenza A_Homo sapiens_hsa051642.10233144
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.09911928
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97537297
14Staphylococcus aureus infection_Homo sapiens_hsa051501.93629414
15Antigen processing and presentation_Homo sapiens_hsa046121.89272822
16Toxoplasmosis_Homo sapiens_hsa051451.85072356
17Allograft rejection_Homo sapiens_hsa053301.79021198
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77018938
19T cell receptor signaling pathway_Homo sapiens_hsa046601.71695413
20TNF signaling pathway_Homo sapiens_hsa046681.69524481
21Graft-versus-host disease_Homo sapiens_hsa053321.65213707
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63316526
23Legionellosis_Homo sapiens_hsa051341.59906169
24Hematopoietic cell lineage_Homo sapiens_hsa046401.58928808
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.57006567
26Acute myeloid leukemia_Homo sapiens_hsa052211.55998025
27Tuberculosis_Homo sapiens_hsa051521.53119544
28Hepatitis B_Homo sapiens_hsa051611.46781490
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46390633
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45151506
31Apoptosis_Homo sapiens_hsa042101.41673247
32Viral myocarditis_Homo sapiens_hsa054161.39986798
33Pertussis_Homo sapiens_hsa051331.39752948
34Chemokine signaling pathway_Homo sapiens_hsa040621.36292566
35Hepatitis C_Homo sapiens_hsa051601.35064973
36Chronic myeloid leukemia_Homo sapiens_hsa052201.34671702
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25957129
38Malaria_Homo sapiens_hsa051441.24390428
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.14238546
40Shigellosis_Homo sapiens_hsa051311.12344663
41Caffeine metabolism_Homo sapiens_hsa002321.10159101
42Bladder cancer_Homo sapiens_hsa052191.08420616
43Asthma_Homo sapiens_hsa053101.08136724
44Pancreatic cancer_Homo sapiens_hsa052121.05081231
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03622383
46Notch signaling pathway_Homo sapiens_hsa043301.01585572
47Small cell lung cancer_Homo sapiens_hsa052221.01193459
48Renal cell carcinoma_Homo sapiens_hsa052110.97587363
49Lysine degradation_Homo sapiens_hsa003100.96802796
50Prolactin signaling pathway_Homo sapiens_hsa049170.96260353
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91030958
52Insulin resistance_Homo sapiens_hsa049310.89889471
53Epstein-Barr virus infection_Homo sapiens_hsa051690.89545239
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.87549940
55HTLV-I infection_Homo sapiens_hsa051660.87416337
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85372337
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.84620839
58Salmonella infection_Homo sapiens_hsa051320.84141388
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.83349186
60Prion diseases_Homo sapiens_hsa050200.83266669
61ErbB signaling pathway_Homo sapiens_hsa040120.82181655
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.81985598
63African trypanosomiasis_Homo sapiens_hsa051430.81254525
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80832611
65GnRH signaling pathway_Homo sapiens_hsa049120.80682246
66Platelet activation_Homo sapiens_hsa046110.80562967
67Viral carcinogenesis_Homo sapiens_hsa052030.79084072
68Choline metabolism in cancer_Homo sapiens_hsa052310.76909386
69Autoimmune thyroid disease_Homo sapiens_hsa053200.75767744
70Type II diabetes mellitus_Homo sapiens_hsa049300.75677968
71Thyroid cancer_Homo sapiens_hsa052160.74509297
72Other glycan degradation_Homo sapiens_hsa005110.71528096
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71366461
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.70168469
75Base excision repair_Homo sapiens_hsa034100.69655154
76Phagosome_Homo sapiens_hsa041450.68850803
77Lysosome_Homo sapiens_hsa041420.68849109
78Endocytosis_Homo sapiens_hsa041440.68844965
79Glioma_Homo sapiens_hsa052140.68329824
80ABC transporters_Homo sapiens_hsa020100.68151766
81HIF-1 signaling pathway_Homo sapiens_hsa040660.67091258
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66415913
83mTOR signaling pathway_Homo sapiens_hsa041500.65991911
84Type I diabetes mellitus_Homo sapiens_hsa049400.65582295
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.62780431
86Complement and coagulation cascades_Homo sapiens_hsa046100.62118019
87Non-small cell lung cancer_Homo sapiens_hsa052230.60036809
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59996145
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59797900
90Fructose and mannose metabolism_Homo sapiens_hsa000510.58762937
91VEGF signaling pathway_Homo sapiens_hsa043700.58010343
92Pentose phosphate pathway_Homo sapiens_hsa000300.57631806
93Amoebiasis_Homo sapiens_hsa051460.56164152
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54444883
95Colorectal cancer_Homo sapiens_hsa052100.53005930
96FoxO signaling pathway_Homo sapiens_hsa040680.47625865
97p53 signaling pathway_Homo sapiens_hsa041150.46311254
98One carbon pool by folate_Homo sapiens_hsa006700.46227304
99MicroRNAs in cancer_Homo sapiens_hsa052060.45923064
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43346111
101Adherens junction_Homo sapiens_hsa045200.42858382
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42436026
103Rheumatoid arthritis_Homo sapiens_hsa053230.42347282
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40074589
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38162709
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36608222
107Proteoglycans in cancer_Homo sapiens_hsa052050.33337205
108Endometrial cancer_Homo sapiens_hsa052130.31999319
109Prostate cancer_Homo sapiens_hsa052150.30980486
110Inositol phosphate metabolism_Homo sapiens_hsa005620.30834931
111MAPK signaling pathway_Homo sapiens_hsa040100.30533572
112Insulin signaling pathway_Homo sapiens_hsa049100.27717104
113Dorso-ventral axis formation_Homo sapiens_hsa043200.27385988
114DNA replication_Homo sapiens_hsa030300.26518696
115Pathways in cancer_Homo sapiens_hsa052000.25518801
116Galactose metabolism_Homo sapiens_hsa000520.24577653
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22475746

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