RNF223

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.85648249
2central nervous system myelination (GO:0022010)7.85648249
3fatty acid elongation (GO:0030497)5.96438786
4glycerophospholipid catabolic process (GO:0046475)5.29331987
5long-chain fatty acid biosynthetic process (GO:0042759)5.25698025
6establishment of skin barrier (GO:0061436)4.95702363
7cholesterol biosynthetic process (GO:0006695)4.86116856
8ensheathment of neurons (GO:0007272)4.84698384
9axon ensheathment (GO:0008366)4.84698384
10regulation of collateral sprouting (GO:0048670)4.83239326
11myelination (GO:0042552)4.79411692
12neuron cell-cell adhesion (GO:0007158)4.77385146
13positive regulation of glomerulus development (GO:0090193)4.75476942
14dendritic spine morphogenesis (GO:0060997)4.60436942
15regulation of glomerulus development (GO:0090192)4.34038128
16regulation of water loss via skin (GO:0033561)4.26443431
17eosinophil chemotaxis (GO:0048245)4.22086114
18sterol biosynthetic process (GO:0016126)4.19933680
19phosphatidylserine acyl-chain remodeling (GO:0036150)4.15078767
20negative regulation of protein localization to cell surface (GO:2000009)4.09010518
21phosphatidylinositol acyl-chain remodeling (GO:0036149)4.04372844
22intestinal epithelial cell development (GO:0060576)3.99790242
23keratinocyte development (GO:0003334)3.97043688
24behavioral response to nicotine (GO:0035095)3.86133167
25negative regulation of neurotransmitter transport (GO:0051589)3.83301463
26negative regulation of neurotransmitter secretion (GO:0046929)3.81984488
27eye photoreceptor cell differentiation (GO:0001754)3.78023947
28photoreceptor cell differentiation (GO:0046530)3.78023947
29low-density lipoprotein particle remodeling (GO:0034374)3.77528772
30eosinophil migration (GO:0072677)3.74360419
31fucose catabolic process (GO:0019317)3.71832797
32L-fucose metabolic process (GO:0042354)3.71832797
33L-fucose catabolic process (GO:0042355)3.71832797
34membrane tubulation (GO:0097320)3.68379454
35lateral sprouting from an epithelium (GO:0060601)3.67023291
36positive regulation of cellular response to insulin stimulus (GO:1900078)3.65743521
37positive regulation of amino acid transport (GO:0051957)3.63433195
38regulation of glutamate secretion (GO:0014048)3.63218590
39protein K11-linked deubiquitination (GO:0035871)3.61887664
40isoprenoid biosynthetic process (GO:0008299)3.61260466
41limb bud formation (GO:0060174)3.58154514
42positive regulation of keratinocyte differentiation (GO:0045618)3.57274346
43keratinization (GO:0031424)3.56685221
44mating behavior (GO:0007617)3.53737022
45L-amino acid import (GO:0043092)3.52052977
46phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.45340155
47positive regulation of T-helper 1 type immune response (GO:0002827)3.44330663
48phosphatidylserine metabolic process (GO:0006658)3.41992062
49establishment of mitochondrion localization (GO:0051654)3.39049674
50hepatocyte apoptotic process (GO:0097284)3.38332051
51piRNA metabolic process (GO:0034587)3.35955746
52negative regulation of axon extension (GO:0030517)3.31129389
53positive regulation of meiotic cell cycle (GO:0051446)3.30204961
54oligodendrocyte differentiation (GO:0048709)3.22387297
55head development (GO:0060322)3.21539105
56multicellular organismal water homeostasis (GO:0050891)3.20242999
57water-soluble vitamin biosynthetic process (GO:0042364)3.19479457
58phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.18457574
59dopaminergic neuron differentiation (GO:0071542)3.16667698
60DNA deamination (GO:0045006)3.12567270
61positive regulation of epidermal cell differentiation (GO:0045606)3.11555721
62transmission of nerve impulse (GO:0019226)3.09159307
63response to histamine (GO:0034776)3.09061465
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.08058808
65negative regulation of axonogenesis (GO:0050771)3.07948989
663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.07098932
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.07098932
68calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03747282
69positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.03719276
70kynurenine metabolic process (GO:0070189)3.02621845
71neuron recognition (GO:0008038)3.01901352
72ectoderm development (GO:0007398)3.01624916
73positive regulation of cellular amine metabolic process (GO:0033240)3.01217104
74cornea development in camera-type eye (GO:0061303)3.00748771
75cranial nerve morphogenesis (GO:0021602)2.99298793
76peristalsis (GO:0030432)2.99282691
77desmosome organization (GO:0002934)2.97971001
78preassembly of GPI anchor in ER membrane (GO:0016254)2.97526578
79cellular ketone body metabolic process (GO:0046950)2.96053521
80response to lipoprotein particle (GO:0055094)2.93220914
81indole-containing compound catabolic process (GO:0042436)2.88346115
82indolalkylamine catabolic process (GO:0046218)2.88346115
83tryptophan catabolic process (GO:0006569)2.88346115
84presynaptic membrane organization (GO:0097090)2.87561689
85axonal fasciculation (GO:0007413)2.86617356
86apical protein localization (GO:0045176)2.85656243
87regulation of hippo signaling (GO:0035330)2.85008813
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84158959
89peptidyl-histidine modification (GO:0018202)2.83533690
90platelet dense granule organization (GO:0060155)2.82939803
91ceramide biosynthetic process (GO:0046513)2.82501519
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.80296664
93positive regulation of interleukin-8 secretion (GO:2000484)2.80232811
94nitric oxide biosynthetic process (GO:0006809)2.80202588
95detection of light stimulus involved in sensory perception (GO:0050962)2.78790657
96detection of light stimulus involved in visual perception (GO:0050908)2.78790657
97alditol phosphate metabolic process (GO:0052646)2.78512932
98presynaptic membrane assembly (GO:0097105)2.77926669
99norepinephrine metabolic process (GO:0042415)2.74941209
100cerebral cortex radially oriented cell migration (GO:0021799)2.74868600
101phosphatidylcholine acyl-chain remodeling (GO:0036151)2.74782151
102substantia nigra development (GO:0021762)2.74765457
103keratinocyte differentiation (GO:0030216)2.73902361
104N-acetylglucosamine metabolic process (GO:0006044)2.73701834
105long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.73102007
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.73084978
107myelin maintenance (GO:0043217)2.72444285
108long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.72324042
109DNA methylation involved in gamete generation (GO:0043046)2.71752632
110rRNA modification (GO:0000154)2.70866598
111dopamine biosynthetic process (GO:0042416)2.70279251
112ketone body metabolic process (GO:1902224)2.69341625
113positive regulation of interleukin-17 production (GO:0032740)2.69252877
114indolalkylamine metabolic process (GO:0006586)2.68629345
115astrocyte development (GO:0014002)2.68470106
116positive regulation of epidermis development (GO:0045684)2.68381499
117neurotransmitter catabolic process (GO:0042135)2.67654737
118cardiac right ventricle morphogenesis (GO:0003215)2.66591380
119activated T cell proliferation (GO:0050798)2.66379474
120hair cycle (GO:0042633)2.65545103
121molting cycle (GO:0042303)2.65545103
122spinal cord motor neuron differentiation (GO:0021522)2.65423807
123pyrimidine-containing compound transmembrane transport (GO:0072531)2.65140496
124phosphatidic acid metabolic process (GO:0046473)2.65100775
125phosphatidic acid biosynthetic process (GO:0006654)2.65100775
126sulfation (GO:0051923)2.64566778
127lung secretory cell differentiation (GO:0061140)2.64253058
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.64078883
129positive regulation of neurological system process (GO:0031646)2.63858276
130response to food (GO:0032094)2.63602217
131DNA double-strand break processing (GO:0000729)2.63232009
132epidermal cell differentiation (GO:0009913)2.60689889
133regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.59767748
134positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.59767748
135amino acid import (GO:0043090)2.59402899
136reflex (GO:0060004)2.59231075
137negative regulation of organelle assembly (GO:1902116)2.58692726
138pseudouridine synthesis (GO:0001522)2.58307122
139regulation of action potential (GO:0098900)2.58250664
140ephrin receptor signaling pathway (GO:0048013)2.58110530
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58005361
142photoreceptor cell development (GO:0042461)2.57654360
143regulation of cell proliferation involved in kidney development (GO:1901722)2.57303226
144regulation of phospholipid biosynthetic process (GO:0071071)2.56663483
145asymmetric protein localization (GO:0008105)2.56084972
146water homeostasis (GO:0030104)2.54946929
147mitotic nuclear envelope reassembly (GO:0007084)2.54887936
148nuclear envelope reassembly (GO:0031468)2.54887936
149positive regulation of synapse assembly (GO:0051965)2.54683873
150response to pheromone (GO:0019236)2.54398466
151regulation of establishment or maintenance of cell polarity (GO:0032878)2.53946195
152positive regulation of oligodendrocyte differentiation (GO:0048714)2.52752825
153respiratory chain complex IV assembly (GO:0008535)2.52546367
154peripheral nervous system axon ensheathment (GO:0032292)2.52490605
155myelination in peripheral nervous system (GO:0022011)2.52490605
156peripheral nervous system development (GO:0007422)2.51763037
157GPI anchor metabolic process (GO:0006505)2.51680028
158phasic smooth muscle contraction (GO:0014821)2.50073204
159detection of temperature stimulus involved in sensory perception (GO:0050961)2.49249621
160detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.49249621
161NADH dehydrogenase complex assembly (GO:0010257)2.48891384
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48891384
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.48891384
164regulation of interleukin-8 secretion (GO:2000482)2.48869401
165regulation of establishment of cell polarity (GO:2000114)2.46663249
166regulation of hexokinase activity (GO:1903299)2.41194331
167regulation of glucokinase activity (GO:0033131)2.41194331
168eye photoreceptor cell development (GO:0042462)2.41075149
169transepithelial transport (GO:0070633)2.40074579
170rRNA methylation (GO:0031167)2.38692791
171protein complex biogenesis (GO:0070271)2.37627759
172termination of RNA polymerase I transcription (GO:0006363)2.35972180
173regulation of T-helper 1 type immune response (GO:0002825)2.35877667
174auditory receptor cell stereocilium organization (GO:0060088)2.34681536
175epidermis development (GO:0008544)2.33679454
176negative regulation of telomere maintenance (GO:0032205)2.33223570
177positive regulation of triglyceride biosynthetic process (GO:0010867)2.32436517
178primary amino compound metabolic process (GO:1901160)2.31021995
179positive regulation of fatty acid oxidation (GO:0046321)2.27650150
180autophagic vacuole fusion (GO:0000046)2.27579436
181tryptophan metabolic process (GO:0006568)2.27383819
182glycosphingolipid biosynthetic process (GO:0006688)2.27081530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human4.55281768
2EZH2_22144423_ChIP-Seq_EOC_Human4.19875940
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.15118590
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77942839
5GBX2_23144817_ChIP-Seq_PC3_Human2.70433921
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59738156
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51701661
8VDR_22108803_ChIP-Seq_LS180_Human2.42237722
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40933261
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.39795216
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38180578
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34723404
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34723404
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.33092703
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.30903863
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29001848
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28425782
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.28360983
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27183228
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26330186
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24297176
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17670265
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16605737
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14380436
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08322897
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.07708926
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06732294
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.06351445
29AR_21572438_ChIP-Seq_LNCaP_Human2.03298583
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00650911
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.96955265
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94826469
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91294399
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90859258
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90418674
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.90245473
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85533869
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85326172
39HOXB7_26014856_ChIP-Seq_BT474_Human1.85114360
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82256611
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79824376
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.79127428
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.78842995
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72605077
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71643731
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71574691
47TP53_22573176_ChIP-Seq_HFKS_Human1.71246502
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.69947563
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67509982
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.66674548
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66044844
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65617597
53TAF15_26573619_Chip-Seq_HEK293_Human1.63809862
54ERA_21632823_ChIP-Seq_H3396_Human1.60370126
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.60242134
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59421755
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59166715
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56312707
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.55276768
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.55276768
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54640323
62HTT_18923047_ChIP-ChIP_STHdh_Human1.54323382
63RNF2_27304074_Chip-Seq_NSC_Mouse1.52629892
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.51741070
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49301982
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46215026
67IGF1R_20145208_ChIP-Seq_DFB_Human1.46143771
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.44879988
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43237452
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43044273
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43044273
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40285635
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38344320
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37860521
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37322761
76REST_21632747_ChIP-Seq_MESCs_Mouse1.37104234
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.36894866
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36534032
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35641941
80STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34437652
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32132806
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.30961081
83NCOR_22424771_ChIP-Seq_293T_Human1.30472916
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29906703
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.29211752
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26915882
87ER_23166858_ChIP-Seq_MCF-7_Human1.25827883
88AR_20517297_ChIP-Seq_VCAP_Human1.25707043
89ELF5_23300383_ChIP-Seq_T47D_Human1.25133135
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.24712199
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24061584
92FUS_26573619_Chip-Seq_HEK293_Human1.23094778
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.22908438
94P53_21459846_ChIP-Seq_SAOS-2_Human1.22472757
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22415784
96IRF1_19129219_ChIP-ChIP_H3396_Human1.22377191
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.18971107
98MYC_18940864_ChIP-ChIP_HL60_Human1.17290416
99DROSHA_22980978_ChIP-Seq_HELA_Human1.16063811
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.15602123
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15058929
102BCAT_22108803_ChIP-Seq_LS180_Human1.13143950
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12995956
104AR_25329375_ChIP-Seq_VCAP_Human1.12529552
105FOXH1_21741376_ChIP-Seq_ESCs_Human1.11760423
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10347239
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10280480
108VDR_23849224_ChIP-Seq_CD4+_Human1.09844956
109ZNF274_21170338_ChIP-Seq_K562_Hela1.09710781
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08535697
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08185320
112RAC3_21632823_ChIP-Seq_H3396_Human1.07541760
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06567892
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06435405
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06303577
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.05212759
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04454147
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04377542
119TP53_18474530_ChIP-ChIP_U2OS_Human1.03987738
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.03122470
121PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02365683
122POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02213547
123P300_19829295_ChIP-Seq_ESCs_Human1.01298806
124TP53_16413492_ChIP-PET_HCT116_Human1.01231442
125GATA4_25053715_ChIP-Seq_YYC3_Human1.01126305
126TAF2_19829295_ChIP-Seq_ESCs_Human1.00830114
127OCT4_20526341_ChIP-Seq_ESCs_Human1.00435832
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00425413
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.00100864
130NANOG_20526341_ChIP-Seq_ESCs_Human1.00065857
131ERG_20517297_ChIP-Seq_VCAP_Human0.97994521
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97735989
133KDM5A_27292631_Chip-Seq_BREAST_Human0.97644615
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.97617565
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.97017397
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96298798
137TCF4_22108803_ChIP-Seq_LS180_Human0.96274355
138STAT3_23295773_ChIP-Seq_U87_Human0.96227160
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96141470
140ESR2_21235772_ChIP-Seq_MCF-7_Human0.95985032
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95732757
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.95535947
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.95314437
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.95244105
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.93803291
146CTCF_27219007_Chip-Seq_Bcells_Human0.93216512
147TP63_17297297_ChIP-ChIP_HaCaT_Human0.92278409
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91379205
149TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91346383
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91222876
151RUNX2_22187159_ChIP-Seq_PCA_Human0.90839198
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89776826
153FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89745225
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89444952
155NANOG_19829295_ChIP-Seq_ESCs_Human0.88312179
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88266950
157GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87865930
158TBL1_22424771_ChIP-Seq_293T_Human0.86857154
159EWS_26573619_Chip-Seq_HEK293_Human0.85045060
160LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84913159
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84613162
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84519739
163CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84488160
164AHR_22903824_ChIP-Seq_MCF-7_Human0.84420323
165RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83892100
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.83392309
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82959638
168PHF8_20622853_ChIP-Seq_HELA_Human0.81701677
169CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81664416
170REST_18959480_ChIP-ChIP_MESCs_Mouse0.81537670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.61959766
2MP0001529_abnormal_vocalization3.57729780
3MP0002796_impaired_skin_barrier3.54649330
4MP0000383_abnormal_hair_follicle3.37880481
5MP0010678_abnormal_skin_adnexa3.10804022
6MP0003880_abnormal_central_pattern3.06258731
7MP0000920_abnormal_myelination3.02731921
8MP0005451_abnormal_body_composition2.98637374
9MP0003950_abnormal_plasma_membrane2.96874110
10MP0004270_analgesia2.83530400
11MP0000427_abnormal_hair_cycle2.83151090
12MP0000566_synostosis2.79503369
13MP0004885_abnormal_endolymph2.59229035
14MP0000778_abnormal_nervous_system2.57402741
15MP0004147_increased_porphyrin_level2.53536328
16MP0001905_abnormal_dopamine_level2.46335975
17MP0004043_abnormal_pH_regulation2.43358124
18MP0008872_abnormal_physiological_respon2.38578462
19MP0004742_abnormal_vestibular_system2.37733830
20MP0008875_abnormal_xenobiotic_pharmacok2.34871473
21MP0000647_abnormal_sebaceous_gland2.13893928
22MP0003878_abnormal_ear_physiology2.11138970
23MP0005377_hearing/vestibular/ear_phenot2.11138970
24MP0003941_abnormal_skin_development2.05920858
25MP0005501_abnormal_skin_physiology2.04663855
26MP0004859_abnormal_synaptic_plasticity1.99837918
27MP0008877_abnormal_DNA_methylation1.98790929
28MP0001486_abnormal_startle_reflex1.92754322
29MP0005275_abnormal_skin_tensile1.92081234
30MP0002064_seizures1.91563787
31MP0002822_catalepsy1.91351840
32MP0005075_abnormal_melanosome_morpholog1.91223250
33MP0003329_amyloid_beta_deposits1.90384140
34MP0003635_abnormal_synaptic_transmissio1.80821885
35MP0003195_calcinosis1.80364381
36MP0004381_abnormal_hair_follicle1.76429824
37MP0002234_abnormal_pharynx_morphology1.74764112
38MP0000604_amyloidosis1.72644309
39MP0003136_yellow_coat_color1.72113359
40MP0003011_delayed_dark_adaptation1.71802552
41MP0001485_abnormal_pinna_reflex1.69294215
42MP0002272_abnormal_nervous_system1.68037482
43MP0004782_abnormal_surfactant_physiolog1.67315628
44MP0003690_abnormal_glial_cell1.62288167
45MP0002736_abnormal_nociception_after1.62149895
46MP0009046_muscle_twitch1.61776169
47MP0001440_abnormal_grooming_behavior1.61350208
48MP0001542_abnormal_bone_strength1.60542846
49MP0003634_abnormal_glial_cell1.60106137
50MP0002876_abnormal_thyroid_physiology1.60001898
51MP0002734_abnormal_mechanical_nocicepti1.56289357
52MP0002063_abnormal_learning/memory/cond1.50743154
53MP0004185_abnormal_adipocyte_glucose1.48778007
54MP0005409_darkened_coat_color1.48408451
55MP0010771_integument_phenotype1.48021587
56MP0002653_abnormal_ependyma_morphology1.47641701
57MP0009745_abnormal_behavioral_response1.46502477
58MP0003787_abnormal_imprinting1.45633170
59MP0002909_abnormal_adrenal_gland1.44862982
60MP0005646_abnormal_pituitary_gland1.44615802
61MP0002572_abnormal_emotion/affect_behav1.40247909
62MP0002254_reproductive_system_inflammat1.39967330
63MP0002837_dystrophic_cardiac_calcinosis1.39458948
64MP0003938_abnormal_ear_development1.36598867
65MP0005408_hypopigmentation1.35030388
66MP0002160_abnormal_reproductive_system1.34822769
67MP0004133_heterotaxia1.33920873
68MP0004924_abnormal_behavior1.33413467
69MP0005386_behavior/neurological_phenoty1.33413467
70MP0000465_gastrointestinal_hemorrhage1.31718977
71MP0010234_abnormal_vibrissa_follicle1.30760012
72MP0002098_abnormal_vibrissa_morphology1.29982161
73MP0005083_abnormal_biliary_tract1.29264546
74MP0004858_abnormal_nervous_system1.28110809
75MP0001346_abnormal_lacrimal_gland1.27658695
76MP0001216_abnormal_epidermal_layer1.25435498
77MP0004264_abnormal_extraembryonic_tissu1.24115275
78MP0003868_abnormal_feces_composition1.22474316
79MP0005171_absent_coat_pigmentation1.22261435
80MP0006072_abnormal_retinal_apoptosis1.19480462
81MP0000462_abnormal_digestive_system1.16998801
82MP0002067_abnormal_sensory_capabilities1.16130259
83MP0001919_abnormal_reproductive_system1.15997206
84MP0004142_abnormal_muscle_tone1.15326114
85MP0003786_premature_aging1.15219862
86MP0003632_abnormal_nervous_system1.14801054
87MP0003937_abnormal_limbs/digits/tail_de1.13285068
88MP0000467_abnormal_esophagus_morphology1.12854719
89MP0005389_reproductive_system_phenotype1.11790987
90MP0000579_abnormal_nail_morphology1.11124333
91MP0002735_abnormal_chemical_nociception1.11121494
92MP0001970_abnormal_pain_threshold1.09733285
93MP0000762_abnormal_tongue_morphology1.08837436
94MP0005253_abnormal_eye_physiology1.08323397
95MP0002751_abnormal_autonomic_nervous1.07426686
96MP0001299_abnormal_eye_distance/1.05887458
97MP0000367_abnormal_coat/_hair1.05310920
98MP0005379_endocrine/exocrine_gland_phen1.03776744
99MP0002693_abnormal_pancreas_physiology1.02977462
100MP0002638_abnormal_pupillary_reflex1.02799498
101MP0002882_abnormal_neuron_morphology1.02352985
102MP0002163_abnormal_gland_morphology1.02032367
103MP0002184_abnormal_innervation0.99323400
104MP0001502_abnormal_circadian_rhythm0.99021524
105MP0000470_abnormal_stomach_morphology0.97632919
106MP0002066_abnormal_motor_capabilities/c0.96529361
107MP0003385_abnormal_body_wall0.96274123
108MP0001765_abnormal_ion_homeostasis0.95707476
109MP0001764_abnormal_homeostasis0.95515556
110MP0001963_abnormal_hearing_physiology0.95151094
111MP0000377_abnormal_hair_follicle0.94911886
112MP0003315_abnormal_perineum_morphology0.94858491
113MP0000538_abnormal_urinary_bladder0.92695915
114MP0002733_abnormal_thermal_nociception0.92007860
115MP0001727_abnormal_embryo_implantation0.91741470
116MP0002102_abnormal_ear_morphology0.91193637
117MP0000372_irregular_coat_pigmentation0.88504550
118MP0003718_maternal_effect0.87158386
119MP0002752_abnormal_somatic_nervous0.86646545
120MP0002152_abnormal_brain_morphology0.86475903
121MP0005645_abnormal_hypothalamus_physiol0.85216846
122MP0003646_muscle_fatigue0.84975192
123MP0003638_abnormal_response/metabolism_0.83925720
124MP0000955_abnormal_spinal_cord0.83491584
125MP0003936_abnormal_reproductive_system0.81002913
126MP0002229_neurodegeneration0.80443772
127MP0001944_abnormal_pancreas_morphology0.80335267
128MP0008058_abnormal_DNA_repair0.80323450
129MP0001968_abnormal_touch/_nociception0.80322639
130MP0002095_abnormal_skin_pigmentation0.80241581
131MP0005666_abnormal_adipose_tissue0.79872817
132MP0001873_stomach_inflammation0.78942404
133MP0003861_abnormal_nervous_system0.77816115
134MP0002938_white_spotting0.77678992
135MP0005636_abnormal_mineral_homeostasis0.76509361
136MP0005174_abnormal_tail_pigmentation0.75747534
137MP0002557_abnormal_social/conspecific_i0.75312349
138MP0008995_early_reproductive_senescence0.73790457
139MP0001664_abnormal_digestion0.73682482
140MP0009780_abnormal_chondrocyte_physiolo0.73378881
141MP0001851_eye_inflammation0.72995945
142MP0001986_abnormal_taste_sensitivity0.72895016
143MP0000026_abnormal_inner_ear0.72612304
144MP0001340_abnormal_eyelid_morphology0.71263045
145MP0003693_abnormal_embryo_hatching0.70183752
146MP0001756_abnormal_urination0.68323520
147MP0005551_abnormal_eye_electrophysiolog0.67885087
148MP0005195_abnormal_posterior_eye0.67126285
149MP0009931_abnormal_skin_appearance0.67122945
150MP0002210_abnormal_sex_determination0.66822976
151MP0000613_abnormal_salivary_gland0.66624843
152MP0009379_abnormal_foot_pigmentation0.66303641
153MP0001501_abnormal_sleep_pattern0.65759174
154MP0003755_abnormal_palate_morphology0.65151541
155MP0001243_abnormal_dermal_layer0.64973170
156MP0005084_abnormal_gallbladder_morpholo0.64417935
157MP0005410_abnormal_fertilization0.64194238
158MP0001177_atelectasis0.64105457
159MP0003123_paternal_imprinting0.63576925
160MP0010386_abnormal_urinary_bladder0.62871810

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.66299966
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.05218783
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.05218783
4Neurofibrillary tangles (HP:0002185)4.59524513
5Abnormality of the corticospinal tract (HP:0002492)4.09451561
6Congenital ichthyosiform erythroderma (HP:0007431)3.95410691
7Pancreatic cysts (HP:0001737)3.87209712
8Cerebral inclusion bodies (HP:0100314)3.76464314
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60343547
10Abnormality of midbrain morphology (HP:0002418)3.58466857
11Molar tooth sign on MRI (HP:0002419)3.58466857
12Congenital stationary night blindness (HP:0007642)3.46758817
13Sensory axonal neuropathy (HP:0003390)3.37384191
14Furrowed tongue (HP:0000221)3.26602399
15True hermaphroditism (HP:0010459)3.20186342
16Polyphagia (HP:0002591)3.15949243
17Pancreatic fibrosis (HP:0100732)3.15241051
18Palmoplantar hyperkeratosis (HP:0000972)3.06967446
19Abnormality of nail color (HP:0100643)2.99294492
20Abnormality of the renal cortex (HP:0011035)2.96841480
21Abnormality of the parathyroid morphology (HP:0011766)2.93884061
22Erythroderma (HP:0001019)2.93370017
23Peripheral hypomyelination (HP:0007182)2.92494411
24Spastic gait (HP:0002064)2.89586688
25Palmar hyperkeratosis (HP:0010765)2.89075362
26Tubular atrophy (HP:0000092)2.88573388
27Termporal pattern (HP:0011008)2.86786894
28Insidious onset (HP:0003587)2.86786894
29Oral leukoplakia (HP:0002745)2.84268751
30Myokymia (HP:0002411)2.83185864
31Nephronophthisis (HP:0000090)2.79744384
32Focal motor seizures (HP:0011153)2.78069691
33Abnormality of the pons (HP:0007361)2.72136672
34Type II lissencephaly (HP:0007260)2.71908051
35Double outlet right ventricle (HP:0001719)2.70775840
36Congenital malformation of the right heart (HP:0011723)2.70775840
37Amelogenesis imperfecta (HP:0000705)2.64235688
38Hypotrichosis (HP:0001006)2.63169882
39Coronal craniosynostosis (HP:0004440)2.60271996
40Autoamputation (HP:0001218)2.59665599
41Pendular nystagmus (HP:0012043)2.57778675
42Abnormality of the axillary hair (HP:0100134)2.56568076
43Abnormality of secondary sexual hair (HP:0009888)2.56568076
44Hyperventilation (HP:0002883)2.55671359
45Hypoplasia of the pons (HP:0012110)2.54316979
46Large for gestational age (HP:0001520)2.51836214
47Anomalous pulmonary venous return (HP:0010772)2.51093727
48J-shaped sella turcica (HP:0002680)2.50959082
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.49163770
50Osteolytic defects of the hand bones (HP:0009699)2.49163770
51Onion bulb formation (HP:0003383)2.48922066
52Abnormality of the renal medulla (HP:0100957)2.48513948
53Small epiphyses (HP:0010585)2.45136701
54Increased circulating renin level (HP:0000848)2.44404969
55Concave nail (HP:0001598)2.44311609
56Segmental peripheral demyelination/remyelination (HP:0003481)2.44098151
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.43304226
58Microretrognathia (HP:0000308)2.43009307
59Dysmetria (HP:0001310)2.41374682
60Ectropion (HP:0000656)2.40889211
61Cupped ear (HP:0000378)2.39562500
62Plantar hyperkeratosis (HP:0007556)2.38883914
63Broad-based gait (HP:0002136)2.37213301
64Abolished electroretinogram (ERG) (HP:0000550)2.37037435
65Pili torti (HP:0003777)2.35699019
66Cystic liver disease (HP:0006706)2.35383767
67Cerebral hypomyelination (HP:0006808)2.34478549
68Intention tremor (HP:0002080)2.34023135
69Abnormal rod and cone electroretinograms (HP:0008323)2.30537685
70Erythema (HP:0010783)2.24760853
71Seborrheic dermatitis (HP:0001051)2.23322302
72White forelock (HP:0002211)2.18258969
73Abnormality of glycolysis (HP:0004366)2.17470039
74Increased serum pyruvate (HP:0003542)2.17470039
75Renal cortical cysts (HP:0000803)2.15026372
76Abnormal eating behavior (HP:0100738)2.14385422
77Chin dimple (HP:0010751)2.14019171
78Congenital, generalized hypertrichosis (HP:0004540)2.13756925
79Abnormality of the pulmonary veins (HP:0011718)2.12358048
80Woolly hair (HP:0002224)2.11371182
81Chronic hepatic failure (HP:0100626)2.09940453
82Progressive inability to walk (HP:0002505)2.09740970
83Leukodystrophy (HP:0002415)2.08782307
84Acute necrotizing encephalopathy (HP:0006965)2.08034003
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.07692015
86Ankle clonus (HP:0011448)2.07272270
87Supranuclear gaze palsy (HP:0000605)2.07125313
88Humeroradial synostosis (HP:0003041)2.06782107
89Synostosis involving the elbow (HP:0003938)2.06782107
90Focal seizures (HP:0007359)2.06711834
91Breast carcinoma (HP:0003002)2.05145832
92Gangrene (HP:0100758)2.02515784
93Macrocytic anemia (HP:0001972)2.02284678
94Methylmalonic acidemia (HP:0002912)2.01366517
95Abnormal biliary tract physiology (HP:0012439)2.00655351
96Bile duct proliferation (HP:0001408)2.00655351
97Patellar aplasia (HP:0006443)2.00504982
98Aplasia/Hypoplasia of the patella (HP:0006498)2.00328309
99Abnormality of alanine metabolism (HP:0010916)2.00138615
100Hyperalaninemia (HP:0003348)2.00138615
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00138615
102Abnormality of the middle phalanges of the toes (HP:0010183)1.99407743
103Renal Fanconi syndrome (HP:0001994)1.99249660
104Chorioretinal atrophy (HP:0000533)1.98761707
105Absent thumb (HP:0009777)1.98513288
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96708342
107Widely spaced teeth (HP:0000687)1.95524630
108Increased IgE level (HP:0003212)1.92414119
109Hypohidrosis (HP:0000966)1.92399015
110Hypoplastic pelvis (HP:0008839)1.91602956
111Severe muscular hypotonia (HP:0006829)1.89601092
112Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89155041
113Conjunctival hamartoma (HP:0100780)1.88997577
114Cerebellar dysplasia (HP:0007033)1.88769625
115Polydipsia (HP:0001959)1.88458780
116Abnormal drinking behavior (HP:0030082)1.88458780
117Medial flaring of the eyebrow (HP:0010747)1.87972051
118Akinesia (HP:0002304)1.87147044
119Slow saccadic eye movements (HP:0000514)1.86738526
120Urinary urgency (HP:0000012)1.86669662
121Sclerocornea (HP:0000647)1.86611446
122Lissencephaly (HP:0001339)1.86360404
123Corneal erosion (HP:0200020)1.85937461
124Septate vagina (HP:0001153)1.85622148
125Brittle hair (HP:0002299)1.85575774
126Hypoplastic left heart (HP:0004383)1.84696480
127Inability to walk (HP:0002540)1.83742313
128Patchy hypopigmentation of hair (HP:0011365)1.83721795
129Hyporeflexia of lower limbs (HP:0002600)1.83563664
130Lower limb muscle weakness (HP:0007340)1.82891136
131Tongue fasciculations (HP:0001308)1.82457166
132Relative macrocephaly (HP:0004482)1.80675082
133Epileptic encephalopathy (HP:0200134)1.80153085
134Hypertensive crisis (HP:0100735)1.79442347
135Lipid accumulation in hepatocytes (HP:0006561)1.78644099
136Lip pit (HP:0100267)1.77774444
137Increased corneal curvature (HP:0100692)1.77622381
138Keratoconus (HP:0000563)1.77622381
139Aplasia/hypoplasia of the uterus (HP:0008684)1.76968154
140Attenuation of retinal blood vessels (HP:0007843)1.75962550
141Progressive cerebellar ataxia (HP:0002073)1.75191971
142Pachygyria (HP:0001302)1.73808710
143Bowel incontinence (HP:0002607)1.73667591
144Methylmalonic aciduria (HP:0012120)1.73646878
145Decreased circulating renin level (HP:0003351)1.73510155
146Stenosis of the external auditory canal (HP:0000402)1.73360319
147Aplasia of the musculature (HP:0100854)1.73234172
148Pruritus (HP:0000989)1.73186202
149Thickened helices (HP:0000391)1.72536465
150Hamartoma of the eye (HP:0010568)1.70790882
151Postaxial foot polydactyly (HP:0001830)1.70738059
152Febrile seizures (HP:0002373)1.70284739
153Disproportionate short-trunk short stature (HP:0003521)1.69954811
154Fragile nails (HP:0001808)1.69639749
155Intellectual disability, moderate (HP:0002342)1.69198136
156Oligodactyly (hands) (HP:0001180)1.68897107
157Muscle fiber splitting (HP:0003555)1.67536323
158Hypoplastic female external genitalia (HP:0012815)1.66855632
159Morphological abnormality of the inner ear (HP:0011390)1.66783955
160Male pseudohermaphroditism (HP:0000037)1.66775908
161Clumsiness (HP:0002312)1.66591898
162Anophthalmia (HP:0000528)1.66470276
163Ketoacidosis (HP:0001993)1.66135534
164Labial hypoplasia (HP:0000066)1.65792214
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65613288
166Retinal dysplasia (HP:0007973)1.65462266
167Difficulty running (HP:0009046)1.65353893
168Abnormality of the salivary glands (HP:0010286)1.65233086
169Ketosis (HP:0001946)1.65181608
170Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64279812
171Pseudobulbar signs (HP:0002200)1.63663140
172Morphological abnormality of the pyramidal tract (HP:0002062)1.63396966
173Curly hair (HP:0002212)1.63325832
174Increased CSF lactate (HP:0002490)1.63256119
175Aplasia/Hypoplasia of the uvula (HP:0010293)1.63171281
176Increased hepatocellular lipid droplets (HP:0006565)1.62876248
177Hepatic necrosis (HP:0002605)1.62875540
178Gait imbalance (HP:0002141)1.62496355
179Renal salt wasting (HP:0000127)1.62434909
180Dialeptic seizures (HP:0011146)1.61923708
181Esophageal atresia (HP:0002032)1.61723486
182Hypodontia (HP:0000668)1.61638820
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61416761
184Gaze-evoked nystagmus (HP:0000640)1.60956107
185Mitochondrial inheritance (HP:0001427)1.59561299
186Hypothermia (HP:0002045)1.59390019
187Duplicated collecting system (HP:0000081)1.58852313
188Agitation (HP:0000713)1.58358972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53235752
2EPHB14.10729214
3STK394.01386391
4MARK13.48954158
5OXSR13.10639693
6ADRBK22.94573788
7MUSK2.83939523
8PNCK2.64115114
9MAPKAPK32.62706284
10TXK2.52985121
11MAPK132.46598777
12GRK12.36466683
13CDK192.35332170
14ACVR1B2.24599564
15BUB12.18387121
16NUAK12.15791354
17MST42.11752003
18ZAK2.10873638
19DYRK22.03108226
20UHMK12.01885471
21MAP3K102.01073924
22TLK11.98699537
23PKN11.98480031
24CSNK1G31.98371679
25EPHA41.98368425
26FGR1.97227177
27CASK1.93940647
28NME11.93875842
29CSNK1A1L1.92398265
30MAPKAPK51.84403845
31BCR1.82306701
32TRPM71.78308223
33BMPR1B1.70695411
34WNK31.57231525
35MAP4K21.56817456
36MET1.56470275
37NTRK31.56028370
38DAPK21.55030154
39NEK11.54288906
40CSNK1G11.53940460
41CAMK2B1.52666960
42CSNK1G21.47106022
43ROCK21.44873685
44RPS6KB21.38461322
45NTRK21.33097703
46IKBKB1.31867043
47MAP2K21.26560818
48BCKDK1.26316134
49WNK41.23964582
50PINK11.21942616
51VRK21.21156792
52CHUK1.19595004
53MAP3K61.15494609
54WNK11.13455531
55TAOK31.13035816
56SIK11.12985173
57LIMK11.12528622
58EPHA21.12146685
59PKN21.05560401
60EPHB21.05479096
61MAP2K11.03595149
62ERBB31.01347598
63CAMK2D1.01018078
64IRAK31.00734695
65FGFR20.98462603
66GRK60.92768206
67PRKD30.91853835
68MAP3K90.90687841
69TNIK0.89830383
70FER0.89337502
71BLK0.87620392
72CDK50.85658208
73MINK10.84725304
74MAP3K20.83340133
75VRK10.83224758
76MAP2K70.82219474
77CAMK2A0.80691529
78BRSK20.79619769
79NEK60.79452233
80PHKG10.78732806
81INSRR0.78121241
82TYRO30.77882536
83PBK0.76468301
84NTRK10.76156887
85CDK150.75917256
86GSK3A0.75804494
87CLK10.74448273
88ABL20.73692264
89DYRK30.73191397
90FES0.73013435
91PAK60.71138215
92CAMK2G0.70702744
93CDK140.69703480
94TRIB30.69649741
95CDK180.69302383
96IRAK10.66929908
97CDK11A0.66759879
98MAP2K40.65502839
99IKBKE0.64775201
100BMPR20.64517110
101TRIM280.64412372
102RPS6KA50.62248426
103EIF2AK30.59640190
104MAP3K40.57766648
105PAK30.56762132
106PRKCQ0.54058662
107CSNK1E0.53392086
108PRKCE0.52778580
109WEE10.52584516
110FYN0.51799528
111STK30.51779384
112CSNK1D0.51527482
113NEK20.51376190
114MAP2K60.49376827
115PRKCI0.49078967
116ADRBK10.49044856
117CSNK1A10.48928021
118SGK2230.48775761
119SGK4940.48775761
120GRK70.47673388
121STK160.47148614
122PTK60.47095543
123PRKCG0.46576991
124STK110.46025644
125ARAF0.45387404
126PDPK10.44777540
127PLK20.44316884
128EIF2AK20.44009930
129PIM20.44008820
130PTK2B0.42806563
131NME20.42414733
132MAPK90.40859210
133MARK30.40059654
134MARK20.39429282
135STK240.39406696
136ERBB40.39011059
137PDGFRB0.38618521
138DAPK10.38211655
139ILK0.37929546
140MAP3K120.37669453
141IRAK40.37479850
142RPS6KA40.37156176
143FGFR10.36765051
144PLK30.35925085
145RIPK40.35807982
146KSR10.35332230
147PAK10.34959813
148PRKCZ0.34792446
149RPS6KB10.34781547
150CHEK20.34619222
151SIK20.34521309
152PIK3CA0.34404606
153TSSK60.33928201
154MST1R0.33071637
155HIPK20.32823577
156DYRK1A0.32730959
157RPS6KA60.32207642
158PRKACA0.32081853
159MAPK150.31474778
160ROCK10.31412573
161PHKG20.31021593
162PLK10.30031691

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.76232679
2Steroid biosynthesis_Homo sapiens_hsa001003.91346581
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.90709309
4Ether lipid metabolism_Homo sapiens_hsa005653.37400925
5Linoleic acid metabolism_Homo sapiens_hsa005912.95476682
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.93007355
7Fatty acid elongation_Homo sapiens_hsa000622.83384052
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76047572
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22406197
10Nitrogen metabolism_Homo sapiens_hsa009102.18421133
11Basal transcription factors_Homo sapiens_hsa030222.15793636
12Axon guidance_Homo sapiens_hsa043602.15793423
13Caffeine metabolism_Homo sapiens_hsa002322.02231734
14Homologous recombination_Homo sapiens_hsa034402.00794172
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.91555410
16Oxidative phosphorylation_Homo sapiens_hsa001901.91037863
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89734356
18Selenocompound metabolism_Homo sapiens_hsa004501.88808025
19Sphingolipid metabolism_Homo sapiens_hsa006001.85867904
20Fanconi anemia pathway_Homo sapiens_hsa034601.77333825
21Arachidonic acid metabolism_Homo sapiens_hsa005901.59253523
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53343795
23Tryptophan metabolism_Homo sapiens_hsa003801.50972879
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48543734
25Fat digestion and absorption_Homo sapiens_hsa049751.48074205
26Glutamatergic synapse_Homo sapiens_hsa047241.47544420
27Nicotine addiction_Homo sapiens_hsa050331.45975617
28Alzheimers disease_Homo sapiens_hsa050101.45222272
29Ribosome_Homo sapiens_hsa030101.42593503
30Collecting duct acid secretion_Homo sapiens_hsa049661.36408809
31Histidine metabolism_Homo sapiens_hsa003401.35925150
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33161032
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31560347
34GABAergic synapse_Homo sapiens_hsa047271.31326831
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26241657
36Proteasome_Homo sapiens_hsa030501.25435021
37Butanoate metabolism_Homo sapiens_hsa006501.23664340
38Circadian rhythm_Homo sapiens_hsa047101.21149639
39Serotonergic synapse_Homo sapiens_hsa047261.20299150
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17495180
41Vibrio cholerae infection_Homo sapiens_hsa051101.15693882
42Sulfur metabolism_Homo sapiens_hsa009201.15264330
43Parkinsons disease_Homo sapiens_hsa050121.13765693
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12956705
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08473973
46Chemical carcinogenesis_Homo sapiens_hsa052041.08186402
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05576431
48Tight junction_Homo sapiens_hsa045301.05044356
49RNA polymerase_Homo sapiens_hsa030201.04392311
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02567267
51Long-term depression_Homo sapiens_hsa047301.00970578
52Propanoate metabolism_Homo sapiens_hsa006400.99973199
53Renal cell carcinoma_Homo sapiens_hsa052110.97209081
54Morphine addiction_Homo sapiens_hsa050320.97206305
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.96247906
56Rheumatoid arthritis_Homo sapiens_hsa053230.95359881
57Hedgehog signaling pathway_Homo sapiens_hsa043400.92246745
58One carbon pool by folate_Homo sapiens_hsa006700.91664928
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.89059506
60Cocaine addiction_Homo sapiens_hsa050300.88933615
61Phototransduction_Homo sapiens_hsa047440.87053589
62Insulin secretion_Homo sapiens_hsa049110.86355745
63Long-term potentiation_Homo sapiens_hsa047200.84643827
64Glutathione metabolism_Homo sapiens_hsa004800.84398095
65Taste transduction_Homo sapiens_hsa047420.83989793
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81315545
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81115256
68RNA degradation_Homo sapiens_hsa030180.79875223
69Dopaminergic synapse_Homo sapiens_hsa047280.79482477
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.79442895
71Retinol metabolism_Homo sapiens_hsa008300.79331111
72beta-Alanine metabolism_Homo sapiens_hsa004100.78281761
73Ras signaling pathway_Homo sapiens_hsa040140.76571344
74ErbB signaling pathway_Homo sapiens_hsa040120.76092289
75Regulation of autophagy_Homo sapiens_hsa041400.75644308
76Peroxisome_Homo sapiens_hsa041460.74884190
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73914317
78Cardiac muscle contraction_Homo sapiens_hsa042600.73446370
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72676498
80Amphetamine addiction_Homo sapiens_hsa050310.71937227
81Protein export_Homo sapiens_hsa030600.71630158
82Pyrimidine metabolism_Homo sapiens_hsa002400.71380877
83Vitamin B6 metabolism_Homo sapiens_hsa007500.70684825
84Metabolic pathways_Homo sapiens_hsa011000.70190120
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69897756
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.69565598
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68578789
88Gastric acid secretion_Homo sapiens_hsa049710.68325665
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67830683
90Renin secretion_Homo sapiens_hsa049240.66918650
91Gap junction_Homo sapiens_hsa045400.65157084
92Nucleotide excision repair_Homo sapiens_hsa034200.65048124
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64905865
94Olfactory transduction_Homo sapiens_hsa047400.63018276
95Pancreatic secretion_Homo sapiens_hsa049720.61454853
96Non-homologous end-joining_Homo sapiens_hsa034500.61407509
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61207106
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60839059
99Vitamin digestion and absorption_Homo sapiens_hsa049770.60043539
100Melanogenesis_Homo sapiens_hsa049160.59903865
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59589696
102Prion diseases_Homo sapiens_hsa050200.58679334
103RNA transport_Homo sapiens_hsa030130.58478633
104Circadian entrainment_Homo sapiens_hsa047130.57955961
105Arginine and proline metabolism_Homo sapiens_hsa003300.57892986
106Cholinergic synapse_Homo sapiens_hsa047250.57564681
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57308364
108p53 signaling pathway_Homo sapiens_hsa041150.55624069
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55519302
110Huntingtons disease_Homo sapiens_hsa050160.54573076
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52673215
112GnRH signaling pathway_Homo sapiens_hsa049120.50259278
113Basal cell carcinoma_Homo sapiens_hsa052170.49188438
114Purine metabolism_Homo sapiens_hsa002300.47632285
115African trypanosomiasis_Homo sapiens_hsa051430.46632331
116Dorso-ventral axis formation_Homo sapiens_hsa043200.46170356
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45355214
118Salivary secretion_Homo sapiens_hsa049700.45072740
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44921943
120Hippo signaling pathway_Homo sapiens_hsa043900.43865606
121Oxytocin signaling pathway_Homo sapiens_hsa049210.43276818
122Ovarian steroidogenesis_Homo sapiens_hsa049130.43207080
123Autoimmune thyroid disease_Homo sapiens_hsa053200.42552614
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41751049
125Wnt signaling pathway_Homo sapiens_hsa043100.41735063
126Phagosome_Homo sapiens_hsa041450.41377884
127Phenylalanine metabolism_Homo sapiens_hsa003600.41147149
128Synaptic vesicle cycle_Homo sapiens_hsa047210.40795895
129Sulfur relay system_Homo sapiens_hsa041220.40439747
130Mineral absorption_Homo sapiens_hsa049780.40392597
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.39485333
132VEGF signaling pathway_Homo sapiens_hsa043700.39456601
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.38891067
134Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38346984
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.37163279
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35170449
137Oocyte meiosis_Homo sapiens_hsa041140.34688335
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.33610289
139Lysosome_Homo sapiens_hsa041420.33363079
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33308259
141Amoebiasis_Homo sapiens_hsa051460.32888360
142Calcium signaling pathway_Homo sapiens_hsa040200.30297514
143Rap1 signaling pathway_Homo sapiens_hsa040150.29624999
144Insulin resistance_Homo sapiens_hsa049310.28409032
145Fatty acid metabolism_Homo sapiens_hsa012120.28140444
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27991874
147Glycerolipid metabolism_Homo sapiens_hsa005610.26728713
148ABC transporters_Homo sapiens_hsa020100.26177561
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26161904
150Tyrosine metabolism_Homo sapiens_hsa003500.26040024
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26005665
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25732555

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