RNF217

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein carboxylation (GO:0018214)4.50536844
2peptidyl-glutamic acid carboxylation (GO:0017187)4.50536844
3L-phenylalanine catabolic process (GO:0006559)4.03274542
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03274542
5aromatic amino acid family catabolic process (GO:0009074)3.79553324
6cellular ketone body metabolic process (GO:0046950)3.62210723
7response to pheromone (GO:0019236)3.62189657
8L-phenylalanine metabolic process (GO:0006558)3.60322768
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60322768
10tryptophan metabolic process (GO:0006568)3.58398462
11tyrosine metabolic process (GO:0006570)3.55045960
12tryptophan catabolic process (GO:0006569)3.51373384
13indole-containing compound catabolic process (GO:0042436)3.51373384
14indolalkylamine catabolic process (GO:0046218)3.51373384
15high-density lipoprotein particle remodeling (GO:0034375)3.42196524
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.31483683
17complement activation, alternative pathway (GO:0006957)3.27160197
18keratinocyte development (GO:0003334)3.27029174
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26347733
20ketone body metabolic process (GO:1902224)3.24352949
21sequestering of extracellular ligand from receptor (GO:0035581)3.22520580
22urea cycle (GO:0000050)3.20173468
23urea metabolic process (GO:0019627)3.20173468
24negative regulation of keratinocyte proliferation (GO:0010839)3.19296987
25limb bud formation (GO:0060174)3.17984588
26bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17694132
27homocysteine metabolic process (GO:0050667)3.15612476
28reverse cholesterol transport (GO:0043691)3.13520626
29prenylation (GO:0097354)3.11039696
30protein prenylation (GO:0018342)3.11039696
31negative regulation of glycogen metabolic process (GO:0070874)3.08798287
32regulation of keratinocyte proliferation (GO:0010837)3.08228527
33kynurenine metabolic process (GO:0070189)3.06114872
34regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.04917546
35positive regulation of protein autophosphorylation (GO:0031954)3.03766121
36regulation of mesoderm development (GO:2000380)3.03140318
37artery development (GO:0060840)3.02774762
38indolalkylamine metabolic process (GO:0006586)3.02114315
39bile acid biosynthetic process (GO:0006699)3.01953661
40negative regulation of glycogen biosynthetic process (GO:0045719)3.01034289
41hemidesmosome assembly (GO:0031581)2.97026136
42phospholipid efflux (GO:0033700)2.96792757
43anterior/posterior axis specification, embryo (GO:0008595)2.95601464
44embryonic foregut morphogenesis (GO:0048617)2.94706081
45organ formation (GO:0048645)2.94627497
46fibrinolysis (GO:0042730)2.94158160
47regulation of fibrinolysis (GO:0051917)2.94026913
48regulation of protein activation cascade (GO:2000257)2.93884612
49desmosome organization (GO:0002934)2.93608251
50dorsal/ventral axis specification (GO:0009950)2.91999641
51alanine transport (GO:0032328)2.91639988
52cholesterol efflux (GO:0033344)2.90928871
53macromolecular complex remodeling (GO:0034367)2.89742024
54plasma lipoprotein particle remodeling (GO:0034369)2.89742024
55protein-lipid complex remodeling (GO:0034368)2.89742024
56regulation of transforming growth factor beta2 production (GO:0032909)2.89253999
57negative regulation of axon guidance (GO:1902668)2.88225013
58negative regulation of fibrinolysis (GO:0051918)2.87611573
59smooth muscle tissue development (GO:0048745)2.87050192
60aromatic amino acid family metabolic process (GO:0009072)2.87004639
61regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86503353
62lymphangiogenesis (GO:0001946)2.81612924
63nitrogen cycle metabolic process (GO:0071941)2.80389060
64neural crest cell development (GO:0014032)2.78823330
65negative regulation of lipase activity (GO:0060192)2.77989782
66triglyceride homeostasis (GO:0070328)2.77848637
67acylglycerol homeostasis (GO:0055090)2.77848637
68otic vesicle formation (GO:0030916)2.76919424
69negative chemotaxis (GO:0050919)2.75827566
70glyoxylate metabolic process (GO:0046487)2.75184220
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.74906605
72positive regulation of fatty acid beta-oxidation (GO:0032000)2.74902268
73regulation of complement activation (GO:0030449)2.74803932
74positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73460566
75positive regulation of glycolytic process (GO:0045821)2.73139477
76negative regulation of activin receptor signaling pathway (GO:0032926)2.73135462
77chondrocyte proliferation (GO:0035988)2.71296065
78lateral sprouting from an epithelium (GO:0060601)2.70792703
79alkaloid metabolic process (GO:0009820)2.70768108
80positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65957488
81intestinal cholesterol absorption (GO:0030299)2.64231974
82proline transport (GO:0015824)2.63809504
83bile acid metabolic process (GO:0008206)2.63783940
84plasma lipoprotein particle clearance (GO:0034381)2.63208714
85pericardium development (GO:0060039)2.62715857
86ER overload response (GO:0006983)2.60571308
87amine catabolic process (GO:0009310)2.60004552
88cellular biogenic amine catabolic process (GO:0042402)2.60004552
89phospholipid homeostasis (GO:0055091)2.57785839
90positive regulation of lipid catabolic process (GO:0050996)2.57517919
91regulation of sarcomere organization (GO:0060297)2.57226947
92negative regulation of hormone biosynthetic process (GO:0032353)2.56613633
93response to growth hormone (GO:0060416)2.56006609
94kidney morphogenesis (GO:0060993)2.55773773
95genitalia morphogenesis (GO:0035112)2.55147447
96interkinetic nuclear migration (GO:0022027)2.55069755
97regulation of cardioblast differentiation (GO:0051890)2.54052461
98keratinocyte proliferation (GO:0043616)2.53787369
99alpha-linolenic acid metabolic process (GO:0036109)2.53213262
100positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.52578797
101lipoprotein metabolic process (GO:0042157)2.48781660
102dicarboxylic acid biosynthetic process (GO:0043650)2.47688266
103bile acid and bile salt transport (GO:0015721)2.46815220
104negative regulation of systemic arterial blood pressure (GO:0003085)2.46800833
105negative regulation of glucose import (GO:0046325)2.45645173
106regulation of cholesterol esterification (GO:0010872)2.44902085
107regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44679472
108cellular glucuronidation (GO:0052695)2.43931570
109embryonic axis specification (GO:0000578)2.43247627
110cysteine metabolic process (GO:0006534)2.42597658
111pyrimidine nucleobase catabolic process (GO:0006208)2.42342590
112regulation of cholesterol homeostasis (GO:2000188)2.42036818
113regulation of hippo signaling (GO:0035330)2.40824055
114UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40386632
115sulfur amino acid catabolic process (GO:0000098)2.40297296
116activin receptor signaling pathway (GO:0032924)2.39965015
117regulation of male gonad development (GO:2000018)2.39439383
118positive regulation of male gonad development (GO:2000020)2.39047453
119negative regulation of protein localization to cell surface (GO:2000009)2.38406048
120signal transduction involved in regulation of gene expression (GO:0023019)2.38256849
121lysine catabolic process (GO:0006554)2.38158553
122lysine metabolic process (GO:0006553)2.38158553
123prostate gland growth (GO:0060736)2.38085429
124regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.38041412
125arginine metabolic process (GO:0006525)2.37897996
126glutamate metabolic process (GO:0006536)2.37793501
127growth hormone receptor signaling pathway (GO:0060396)2.34732925
128midgut development (GO:0007494)2.34563461
129atrial cardiac muscle cell action potential (GO:0086014)2.34152795
130regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.33524841
131sterol transport (GO:0015918)2.32589854
132cholesterol transport (GO:0030301)2.32589854
133mesenchymal-epithelial cell signaling (GO:0060638)2.31880838
134negative regulation of hormone metabolic process (GO:0032351)2.31058718
135regulation of action potential (GO:0098900)2.30871131
136low-density lipoprotein particle remodeling (GO:0034374)2.30765604
137tachykinin receptor signaling pathway (GO:0007217)2.30477883
138alpha-amino acid catabolic process (GO:1901606)2.30183562
139regulation of axon extension involved in axon guidance (GO:0048841)2.29594025
140negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.28802310
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.28681304
142glucuronate metabolic process (GO:0019585)2.28447442
143uronic acid metabolic process (GO:0006063)2.28447442
144cellular response to BMP stimulus (GO:0071773)2.27647198
145response to BMP (GO:0071772)2.27647198
146regulation of skeletal muscle contraction (GO:0014819)2.27615205
147positive regulation of hemostasis (GO:1900048)2.26195987
148positive regulation of blood coagulation (GO:0030194)2.26195987
149nucleobase catabolic process (GO:0046113)2.26143199
150replication fork processing (GO:0031297)2.25136343
151plasma lipoprotein particle organization (GO:0071827)2.24731257
152pancreas development (GO:0031016)2.24667731
153embryonic pattern specification (GO:0009880)2.24577893
154vascular smooth muscle contraction (GO:0014829)2.23866371
155renal tubule morphogenesis (GO:0061333)2.23789102
156regulation of triglyceride catabolic process (GO:0010896)2.23123717
157regulation of lipid catabolic process (GO:0050994)2.22451079
158regulation of cardiac muscle cell differentiation (GO:2000725)2.22283622
159positive regulation of glycogen biosynthetic process (GO:0045725)2.22197521
160nephron tubule formation (GO:0072079)2.21520767
161positive regulation of fatty acid oxidation (GO:0046321)2.21457907
162negative regulation of cellular carbohydrate metabolic process (GO:0010677)2.20735172
163regulation of hexokinase activity (GO:1903299)2.19603766
164regulation of glucokinase activity (GO:0033131)2.19603766
165drug catabolic process (GO:0042737)2.19496881
166very-low-density lipoprotein particle assembly (GO:0034379)2.19378140
167substrate adhesion-dependent cell spreading (GO:0034446)2.18861394
168nodal signaling pathway (GO:0038092)2.18671417
169benzene-containing compound metabolic process (GO:0042537)2.18542518
170cartilage morphogenesis (GO:0060536)2.18514663
171negative regulation of smooth muscle cell differentiation (GO:0051151)2.18427151
172plasma membrane repair (GO:0001778)2.17656687
173cardiac muscle cell action potential (GO:0086001)2.16913660
174blood coagulation, intrinsic pathway (GO:0007597)2.16497938
175negative regulation of coagulation (GO:0050819)2.16268369
176phasic smooth muscle contraction (GO:0014821)2.15032426
177positive regulation of actin filament depolymerization (GO:0030836)2.14872093
178collagen fibril organization (GO:0030199)2.14369030
179intraciliary transport (GO:0042073)2.13967429
180platelet dense granule organization (GO:0060155)2.13669624
181regulation of axon guidance (GO:1902667)2.13590139
182somite rostral/caudal axis specification (GO:0032525)2.13457553
183regulation of protein autophosphorylation (GO:0031952)2.13226280
184positive regulation of cardiac muscle hypertrophy (GO:0010613)2.10261238
185positive regulation of muscle hypertrophy (GO:0014742)2.10261238
186regulation of calcium ion import (GO:0090279)2.09522797
187nucleus localization (GO:0051647)2.08011445
188embryonic heart tube development (GO:0035050)2.07412024
189nephron tubule morphogenesis (GO:0072078)2.06414217
190nephron epithelium morphogenesis (GO:0072088)2.06414217
191establishment of protein localization to Golgi (GO:0072600)2.03616886
192positive regulation of meiosis (GO:0045836)2.03358055
193myofibril assembly (GO:0030239)2.03227287
194photoreceptor cell maintenance (GO:0045494)2.03147763
195L-fucose catabolic process (GO:0042355)2.02940466
196fucose catabolic process (GO:0019317)2.02940466
197L-fucose metabolic process (GO:0042354)2.02940466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79059888
2SALL1_21062744_ChIP-ChIP_HESCs_Human2.99531280
3* RXR_22158963_ChIP-Seq_LIVER_Mouse2.78781553
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.61092179
5FUS_26573619_Chip-Seq_HEK293_Human2.51562554
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.43640953
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20175633
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.13385858
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13331949
10EWS_26573619_Chip-Seq_HEK293_Human2.10962200
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10578749
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.09691997
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01426398
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.98245692
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87414972
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.86491819
17GBX2_23144817_ChIP-Seq_PC3_Human1.78227629
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74563902
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71449806
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.70602977
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.70446078
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70145287
23* EZH2_27294783_Chip-Seq_NPCs_Mouse1.68223028
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66595101
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64214434
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64214434
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63381611
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63276046
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61725938
30ER_23166858_ChIP-Seq_MCF-7_Human1.60896714
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59526537
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59073734
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58572668
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58279619
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55870524
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.55318779
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55198951
38IGF1R_20145208_ChIP-Seq_DFB_Human1.54413291
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.50813710
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50011133
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48973233
42TP53_18474530_ChIP-ChIP_U2OS_Human1.48017820
43AR_21572438_ChIP-Seq_LNCaP_Human1.47748597
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45783388
45BRD4_25478319_ChIP-Seq_HGPS_Human1.45666545
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45511561
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43469709
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.39316642
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38546877
50EZH2_22144423_ChIP-Seq_EOC_Human1.38263294
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38021625
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38021625
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37909924
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35846617
55P53_22387025_ChIP-Seq_ESCs_Mouse1.35315314
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.34706951
57* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33953550
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33745971
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.33546616
60TCF4_23295773_ChIP-Seq_U87_Human1.33490467
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32725820
62CJUN_26792858_Chip-Seq_BT549_Human1.31456082
63CBP_20019798_ChIP-Seq_JUKART_Human1.29993737
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29993737
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29568248
66* EZH2_27304074_Chip-Seq_ESCs_Mouse1.28370189
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28143857
68TP53_16413492_ChIP-PET_HCT116_Human1.27821818
69* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27500666
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26742624
71* CDX2_22108803_ChIP-Seq_LS180_Human1.26150450
72* CRX_20693478_ChIP-Seq_RETINA_Mouse1.25871446
73P300_19829295_ChIP-Seq_ESCs_Human1.24988766
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.24782151
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23334989
76AHR_22903824_ChIP-Seq_MCF-7_Human1.23255460
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.21687150
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.20944217
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20699016
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18575176
81BCAT_22108803_ChIP-Seq_LS180_Human1.18538227
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16866903
83TAF15_26573619_Chip-Seq_HEK293_Human1.16215344
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15880315
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15604848
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.15154788
87* EZH2_27294783_Chip-Seq_ESCs_Mouse1.14950819
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.14537786
89* RNF2_27304074_Chip-Seq_ESCs_Mouse1.14314297
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13641724
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.13289448
92AR_25329375_ChIP-Seq_VCAP_Human1.13103055
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12580950
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.12451145
95P300_18555785_Chip-Seq_ESCs_Mouse1.12257878
96* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11591953
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11587335
98SOX2_20726797_ChIP-Seq_SW620_Human1.11109272
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.11058975
100NANOG_19829295_ChIP-Seq_ESCs_Human1.10288789
101SOX2_19829295_ChIP-Seq_ESCs_Human1.10288789
102TBL1_22424771_ChIP-Seq_293T_Human1.09884489
103* FLI1_21867929_ChIP-Seq_TH2_Mouse1.09460569
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08796583
105* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08487788
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08261894
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08198379
108* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07773543
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07766767
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.06768929
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.06233330
112* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06225797
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06108497
114* TP63_23658742_ChIP-Seq_EP156T_Human1.06066177
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.05679996
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05326656
117DROSHA_22980978_ChIP-Seq_HELA_Human1.04971951
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04496901
119ZNF274_21170338_ChIP-Seq_K562_Hela1.03193806
120RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02343545
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.02158728
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00841547
123STAT3_23295773_ChIP-Seq_U87_Human1.00580724
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.00571799
125VDR_22108803_ChIP-Seq_LS180_Human0.99463648
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98941822
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98913617
128RXR_22108803_ChIP-Seq_LS180_Human0.98741156
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.98529576
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98009455
131* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97842553
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96817519
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95284771
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94241835
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92681296
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92366081
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91159091
138TCF4_22108803_ChIP-Seq_LS180_Human0.89336127
139RUNX2_22187159_ChIP-Seq_PCA_Human0.88975030
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.88738711
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88337816
142* GATA2_21666600_ChIP-Seq_HMVEC_Human0.88334979
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87083259
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85217322
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83516439
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81875245
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81744341
148HTT_18923047_ChIP-ChIP_STHdh_Human0.81734721
149SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81649226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.65901629
2MP0002139_abnormal_hepatobiliary_system4.71891523
3MP0005083_abnormal_biliary_tract3.66281750
4MP0003950_abnormal_plasma_membrane3.63131263
5MP0006054_spinal_hemorrhage3.62540096
6MP0005085_abnormal_gallbladder_physiolo3.56132980
7MP0005365_abnormal_bile_salt3.49814479
8MP0005360_urolithiasis3.23046122
9MP0003252_abnormal_bile_duct2.74346662
10MP0003195_calcinosis2.70338243
11MP0002877_abnormal_melanocyte_morpholog2.41792077
12MP0008875_abnormal_xenobiotic_pharmacok2.26076870
13MP0004084_abnormal_cardiac_muscle2.17978436
14MP0002138_abnormal_hepatobiliary_system2.17580992
15MP0003705_abnormal_hypodermis_morpholog2.09507732
16MP0010329_abnormal_lipoprotein_level2.07063116
17MP0000383_abnormal_hair_follicle2.04109896
18MP0005275_abnormal_skin_tensile1.96622804
19MP0009780_abnormal_chondrocyte_physiolo1.96430885
20MP0004215_abnormal_myocardial_fiber1.94617849
21MP0010678_abnormal_skin_adnexa1.92144382
22MP0002938_white_spotting1.91203303
23MP0003191_abnormal_cellular_cholesterol1.86412306
24MP0004145_abnormal_muscle_electrophysio1.84039754
25MP0008775_abnormal_heart_ventricle1.79959224
26MP0002102_abnormal_ear_morphology1.78742344
27MP0001879_abnormal_lymphatic_vessel1.72671345
28MP0003890_abnormal_embryonic-extraembry1.71131909
29MP0005248_abnormal_Harderian_gland1.67329966
30MP0003868_abnormal_feces_composition1.65389566
31MP0009697_abnormal_copulation1.64229267
32MP0003937_abnormal_limbs/digits/tail_de1.61084759
33MP0002282_abnormal_trachea_morphology1.59046811
34MP0009250_abnormal_appendicular_skeleto1.58516518
35MP0000579_abnormal_nail_morphology1.57269690
36MP0008438_abnormal_cutaneous_collagen1.57125467
37MP0002295_abnormal_pulmonary_circulatio1.56467324
38MP0000749_muscle_degeneration1.54944636
39MP0010386_abnormal_urinary_bladder1.53119026
40MP0002254_reproductive_system_inflammat1.52408630
41MP0003300_gastrointestinal_ulcer1.50623501
42MP0005503_abnormal_tendon_morphology1.40503913
43MP0001666_abnormal_nutrient_absorption1.38166652
44MP0005171_absent_coat_pigmentation1.35999951
45MP0003755_abnormal_palate_morphology1.34318281
46MP0005174_abnormal_tail_pigmentation1.31842063
47MP0003283_abnormal_digestive_organ1.31410287
48MP0004484_altered_response_of1.28122942
49MP0003119_abnormal_digestive_system1.27799825
50MP0010234_abnormal_vibrissa_follicle1.27407456
51MP0002118_abnormal_lipid_homeostasis1.26918593
52MP0004036_abnormal_muscle_relaxation1.26789347
53MP0005620_abnormal_muscle_contractility1.26702043
54MP0009379_abnormal_foot_pigmentation1.25512226
55MP0005408_hypopigmentation1.24572650
56MP0003935_abnormal_craniofacial_develop1.20652006
57MP0000762_abnormal_tongue_morphology1.20325510
58MP0002876_abnormal_thyroid_physiology1.19166910
59MP0010030_abnormal_orbit_morphology1.18438917
60MP0000647_abnormal_sebaceous_gland1.18244313
61MP0001661_extended_life_span1.17576479
62MP0004085_abnormal_heartbeat1.14954089
63MP0005058_abnormal_lysosome_morphology1.12346059
64MP0000538_abnormal_urinary_bladder1.12145969
65MP0000015_abnormal_ear_pigmentation1.11167721
66MP0001984_abnormal_olfaction1.10683335
67MP0010368_abnormal_lymphatic_system1.10105460
68MP0000537_abnormal_urethra_morphology1.09744991
69MP0002896_abnormal_bone_mineralization1.09526293
70MP0003279_aneurysm1.08699450
71MP0005332_abnormal_amino_acid1.07944829
72MP0002160_abnormal_reproductive_system1.07261774
73MP0004134_abnormal_chest_morphology1.07029865
74MP0005220_abnormal_exocrine_pancreas1.05793252
75MP0001944_abnormal_pancreas_morphology1.04045685
76MP0002233_abnormal_nose_morphology1.03768806
77MP0000609_abnormal_liver_physiology1.03629925
78MP0009764_decreased_sensitivity_to1.03524312
79MP0002693_abnormal_pancreas_physiology1.01155834
80MP0005623_abnormal_meninges_morphology1.00009021
81MP0005646_abnormal_pituitary_gland0.98946562
82MP0002078_abnormal_glucose_homeostasis0.98668958
83MP0005551_abnormal_eye_electrophysiolog0.98495702
84MP0003045_fibrosis0.96886771
85MP0002972_abnormal_cardiac_muscle0.96254762
86MP0002837_dystrophic_cardiac_calcinosis0.95340419
87MP0005187_abnormal_penis_morphology0.93240146
88MP0002109_abnormal_limb_morphology0.93226808
89MP0004272_abnormal_basement_membrane0.91542813
90MP0000767_abnormal_smooth_muscle0.90308153
91MP0001485_abnormal_pinna_reflex0.89869871
92MP0003566_abnormal_cell_adhesion0.88929566
93MP0005595_abnormal_vascular_smooth0.88323205
94MP0003385_abnormal_body_wall0.88212033
95MP0006072_abnormal_retinal_apoptosis0.87660218
96MP0001286_abnormal_eye_development0.87571953
97MP0000427_abnormal_hair_cycle0.87523144
98MP0005084_abnormal_gallbladder_morpholo0.86697849
99MP0002009_preneoplasia0.86308422
100MP0004270_analgesia0.86085612
101MP0005253_abnormal_eye_physiology0.85728026
102MP0002108_abnormal_muscle_morphology0.85655591
103MP0000013_abnormal_adipose_tissue0.85027882
104MP0002060_abnormal_skin_morphology0.85002494
105MP0009384_cardiac_valve_regurgitation0.84720038
106MP0004885_abnormal_endolymph0.84673076
107MP0000678_abnormal_parathyroid_gland0.84523995
108MP0003122_maternal_imprinting0.84063479
109MP0009053_abnormal_anal_canal0.83188490
110MP0003942_abnormal_urinary_system0.83159679
111MP0004130_abnormal_muscle_cell0.82375073
112MP0002168_other_aberrant_phenotype0.81698909
113MP0002909_abnormal_adrenal_gland0.81454788
114MP0005319_abnormal_enzyme/_coenzyme0.81134232
115MP0004133_heterotaxia0.80172922
116MP0003646_muscle_fatigue0.79859727
117MP0002796_impaired_skin_barrier0.79201674
118MP0000230_abnormal_systemic_arterial0.78847113
119MP0003941_abnormal_skin_development0.78737009
120MP0002115_abnormal_skeleton_extremities0.78693929
121MP0003183_abnormal_peptide_metabolism0.78481873
122MP0003137_abnormal_impulse_conducting0.77078383
123MP0000639_abnormal_adrenal_gland0.76787789
124MP0001299_abnormal_eye_distance/0.76009192
125MP0000428_abnormal_craniofacial_morphol0.75255475
126MP0003943_abnormal_hepatobiliary_system0.75220185
127MP0002098_abnormal_vibrissa_morphology0.75120559
128MP0004043_abnormal_pH_regulation0.73106418
129MP0003567_abnormal_fetal_cardiomyocyte0.72610406
130MP0005367_renal/urinary_system_phenotyp0.72481272
131MP0000516_abnormal_urinary_system0.72481272
132MP0000432_abnormal_head_morphology0.72214777
133MP0001486_abnormal_startle_reflex0.71517421
134MP0005334_abnormal_fat_pad0.70633174
135MP0009840_abnormal_foam_cell0.69471667
136MP0010352_gastrointestinal_tract_polyps0.69382815
137MP0001270_distended_abdomen0.69377597
138MP0004019_abnormal_vitamin_homeostasis0.69246087
139MP0002127_abnormal_cardiovascular_syste0.68929224
140MP0001756_abnormal_urination0.68797976
141MP0000163_abnormal_cartilage_morphology0.68783238
142MP0000631_abnormal_neuroendocrine_gland0.68058064
143MP0005257_abnormal_intraocular_pressure0.67950114
144MP0002128_abnormal_blood_circulation0.67805717
145MP0000372_irregular_coat_pigmentation0.67537409
146MP0005535_abnormal_body_temperature0.67230966
147MP0003959_abnormal_lean_body0.67073757
148MP0005167_abnormal_blood-brain_barrier0.64790435
149MP0001881_abnormal_mammary_gland0.64493445
150MP0001346_abnormal_lacrimal_gland0.62896157
151MP0002234_abnormal_pharynx_morphology0.62277317
152MP0003303_peritoneal_inflammation0.61745926
153MP0004859_abnormal_synaptic_plasticity0.61343718
154MP0002177_abnormal_outer_ear0.61181086
155MP0005508_abnormal_skeleton_morphology0.61046599
156MP0002998_abnormal_bone_remodeling0.60925931
157MP0003091_abnormal_cell_migration0.60885314
158MP0002928_abnormal_bile_duct0.60310200
159MP0005448_abnormal_energy_balance0.60215416
160MP0001177_atelectasis0.58910044
161MP0001191_abnormal_skin_condition0.58782494
162MP0000371_diluted_coat_color0.57395005
163MP0005647_abnormal_sex_gland0.56670859

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.51799811
2Joint hemorrhage (HP:0005261)4.50385402
3Intrahepatic cholestasis (HP:0001406)4.23661404
4Epidermoid cyst (HP:0200040)4.21005729
5Deep venous thrombosis (HP:0002625)4.19806270
6Xanthomatosis (HP:0000991)4.04247097
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.01092360
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53992941
9Abnormality of the common coagulation pathway (HP:0010990)3.49872643
10Ketoacidosis (HP:0001993)3.44930613
11Conjugated hyperbilirubinemia (HP:0002908)3.43638692
12Skin nodule (HP:0200036)3.36743216
13Hypoglycemic coma (HP:0001325)3.27886974
14Hypoglycemic seizures (HP:0002173)3.24941231
15Abnormality of the intrinsic pathway (HP:0010989)3.03950368
16Complement deficiency (HP:0004431)3.01918734
17Hypoalphalipoproteinemia (HP:0003233)2.96738809
18Mucopolysacchariduria (HP:0008155)2.93723505
19Urinary glycosaminoglycan excretion (HP:0003541)2.93723505
20Hyperlipoproteinemia (HP:0010980)2.93197136
21Symptomatic seizures (HP:0011145)2.81866129
22Myocardial infarction (HP:0001658)2.81736773
23Hypobetalipoproteinemia (HP:0003563)2.79637680
24Hyperinsulinemic hypoglycemia (HP:0000825)2.77159064
25J-shaped sella turcica (HP:0002680)2.76835091
26Recurrent gram-negative bacterial infections (HP:0005420)2.75919139
27Abnormality of the ischium (HP:0003174)2.73895209
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72235125
29Menorrhagia (HP:0000132)2.68364998
30Hypolipoproteinemia (HP:0010981)2.67748324
31Turricephaly (HP:0000262)2.66646127
32Ketosis (HP:0001946)2.64186598
33Calf muscle hypertrophy (HP:0008981)2.62948289
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61674179
35Abnormality of polysaccharide metabolism (HP:0011012)2.61674179
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61674179
37Abnormality of the renal cortex (HP:0011035)2.59036339
38Renal cortical cysts (HP:0000803)2.57188531
39Hyperglycemia (HP:0003074)2.56884137
40Hypoplastic labia majora (HP:0000059)2.55406793
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52062730
42Abnormality of complement system (HP:0005339)2.47683319
43Abnormality of the labia majora (HP:0012881)2.46681528
44Hypoplastic ischia (HP:0003175)2.44606992
45Tubular atrophy (HP:0000092)2.41948990
46Disproportionate short-trunk short stature (HP:0003521)2.41131665
47Amniotic constriction ring (HP:0009775)2.40904125
48Abnormality of placental membranes (HP:0011409)2.40904125
49Increased corneal curvature (HP:0100692)2.40680027
50Keratoconus (HP:0000563)2.40680027
51Abnormality of the lumbar spine (HP:0100712)2.39793642
52Intestinal atresia (HP:0011100)2.38926208
53Fatigable weakness (HP:0003473)2.34275957
54Abnormality of the neuromuscular junction (HP:0003398)2.34275957
55Generalized hypopigmentation of hair (HP:0011358)2.34019372
56Pancreatic fibrosis (HP:0100732)2.31309613
57Pancreatic cysts (HP:0001737)2.31034766
58Fair hair (HP:0002286)2.31004175
59Fat malabsorption (HP:0002630)2.30332545
60Abnormality of midbrain morphology (HP:0002418)2.29718509
61Molar tooth sign on MRI (HP:0002419)2.29718509
62Muscle hypertrophy of the lower extremities (HP:0008968)2.28814935
63True hermaphroditism (HP:0010459)2.28575812
64Alopecia of scalp (HP:0002293)2.27949094
65Onycholysis (HP:0001806)2.27499190
66Mitral stenosis (HP:0001718)2.26543604
67Enlarged penis (HP:0000040)2.20605473
68Aortic dissection (HP:0002647)2.20509345
69Volvulus (HP:0002580)2.20349842
70Abnormal pancreas size (HP:0012094)2.19638032
71Blue irides (HP:0000635)2.19476461
72Atrophic scars (HP:0001075)2.16758544
73Metatarsus adductus (HP:0001840)2.15461506
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15258270
75Short hallux (HP:0010109)2.14477168
76Hepatocellular carcinoma (HP:0001402)2.11474917
77Nephronophthisis (HP:0000090)2.10346151
78Popliteal pterygium (HP:0009756)2.09845956
79Dysostosis multiplex (HP:0000943)2.09589346
80Abnormality of the renal medulla (HP:0100957)2.04869416
81Limited hip movement (HP:0008800)2.04272601
82Lymphangioma (HP:0100764)2.02670656
83Furrowed tongue (HP:0000221)2.02335200
84Albinism (HP:0001022)2.02144636
85Abnormality of the calf musculature (HP:0001430)1.98586867
86Eczematoid dermatitis (HP:0000976)1.97413550
87Asymmetry of the thorax (HP:0001555)1.97205803
88Abnormality of the nasal septum (HP:0000419)1.96463425
89Follicular hyperkeratosis (HP:0007502)1.96052652
90Aplasia/Hypoplasia of the hallux (HP:0008362)1.95497594
91Plantar hyperkeratosis (HP:0007556)1.95252259
92Recurrent corneal erosions (HP:0000495)1.94457400
93Aortic aneurysm (HP:0004942)1.94399756
94Chorioretinal atrophy (HP:0000533)1.93466383
95Type 2 muscle fiber atrophy (HP:0003554)1.93378665
96Hematochezia (HP:0002573)1.91212553
97Hyperventilation (HP:0002883)1.90883473
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90795560
99Preaxial foot polydactyly (HP:0001841)1.90272556
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.89731358
101Hypercholesterolemia (HP:0003124)1.88979948
102Abnormality of secondary sexual hair (HP:0009888)1.88782197
103Abnormality of the axillary hair (HP:0100134)1.88782197
104Palmar hyperkeratosis (HP:0010765)1.88468036
105Hydroxyprolinuria (HP:0003080)1.88163266
106Abnormality of proline metabolism (HP:0010907)1.88163266
107Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87998827
108Aqueductal stenosis (HP:0002410)1.87645333
109Bifid tongue (HP:0010297)1.86908180
110Abnormality of the phalanges of the 5th finger (HP:0004213)1.84861293
111Congenital, generalized hypertrichosis (HP:0004540)1.84068341
112Late onset (HP:0003584)1.83930572
113Abnormality of methionine metabolism (HP:0010901)1.83817874
114Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.82896730
115Congenital sensorineural hearing impairment (HP:0008527)1.82705267
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.82628233
117Palmoplantar hyperkeratosis (HP:0000972)1.82623212
118Gastrointestinal atresia (HP:0002589)1.81376746
119Medial flaring of the eyebrow (HP:0010747)1.80743787
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.80271118
121Hypoplastic iliac wings (HP:0002866)1.79528291
122Cardiovascular calcification (HP:0011915)1.78637813
123Genital tract atresia (HP:0001827)1.78060013
124Cystic hygroma (HP:0000476)1.77000108
125Hepatoblastoma (HP:0002884)1.76753067
126Subacute progressive viral hepatitis (HP:0006572)1.75562589
127Large for gestational age (HP:0001520)1.75037015
128Aplasia of the musculature (HP:0100854)1.74724254
129Spontaneous abortion (HP:0005268)1.74449890
130Febrile seizures (HP:0002373)1.73618404
131Labial hypoplasia (HP:0000066)1.72516111
132Hyporeflexia of lower limbs (HP:0002600)1.72415717
133Delayed gross motor development (HP:0002194)1.72404953
134Curly hair (HP:0002212)1.72341996
135Hypothermia (HP:0002045)1.71527538
136Agitation (HP:0000713)1.71485940
137Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.71383939
138Beaking of vertebral bodies (HP:0004568)1.70987686
139Vaginal atresia (HP:0000148)1.70469339
140Generalized hypopigmentation (HP:0007513)1.70265623
141Type 1 muscle fiber predominance (HP:0003803)1.70122103
142Exotropia (HP:0000577)1.69459315
143Atrial fibrillation (HP:0005110)1.68648019
144Generalized tonic-clonic seizures (HP:0002069)1.68544778
145Hamartoma of the eye (HP:0010568)1.68191353
146Vascular calcification (HP:0004934)1.68020630
147Fetal akinesia sequence (HP:0001989)1.66892796
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65582696
149Gastrointestinal infarctions (HP:0005244)1.65371738
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64502548
151Abnormality of alanine metabolism (HP:0010916)1.64502548
152Hyperalaninemia (HP:0003348)1.64502548
153Exostoses (HP:0100777)1.64376650
154Soft skin (HP:0000977)1.64376349
155Hip contracture (HP:0003273)1.63824717
156Akinesia (HP:0002304)1.63509150
157Widely spaced teeth (HP:0000687)1.61315619
158Distal arthrogryposis (HP:0005684)1.61164875
159Gingival bleeding (HP:0000225)1.60903851
160Alveolar cell carcinoma (HP:0006519)1.60474345
161Hyperammonemia (HP:0001987)1.59995977
162Sensorimotor neuropathy (HP:0007141)1.59875437
163Macroorchidism (HP:0000053)1.59634049
164Right ventricular cardiomyopathy (HP:0011663)1.59312212
165Neoplasm of the tracheobronchial system (HP:0100552)1.58992039
166Small hand (HP:0200055)1.58343208
167Decreased lacrimation (HP:0000633)1.58124919
168Mesomelia (HP:0003027)1.57981060
169Abnormality of purine metabolism (HP:0004352)1.57730670
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.57365123
171Gaze-evoked nystagmus (HP:0000640)1.57313023
172Broad metatarsal (HP:0001783)1.57172182
173Malignant hyperthermia (HP:0002047)1.57089006
174Systemic lupus erythematosus (HP:0002725)1.57025836
175Hypophosphatemic rickets (HP:0004912)1.55686096
176Preauricular pit (HP:0004467)1.55262188
177Periauricular skin pits (HP:0100277)1.55262188
178Syringomyelia (HP:0003396)1.53640524
179Spinal cord lesions (HP:0100561)1.53640524
180Duplicated collecting system (HP:0000081)1.53513071
181Insulin-resistant diabetes mellitus (HP:0000831)1.53509340
182Decreased muscle mass (HP:0003199)1.52852843
183Conjunctival hamartoma (HP:0100780)1.52683865
184Abnormality of the middle phalanges of the toes (HP:0010183)1.52532901
185Thoracic kyphosis (HP:0002942)1.52231182
186Abnormality of the renal collecting system (HP:0004742)1.51841155
187Hypoplasia of the uterus (HP:0000013)1.51579076
188Thin bony cortex (HP:0002753)1.51481630
189Absent phalangeal crease (HP:0006109)1.51154722
190Gingivitis (HP:0000230)1.48608546
191Widely patent fontanelles and sutures (HP:0004492)1.47841648
192Hypophosphatemia (HP:0002148)1.46745353
193Esophageal varix (HP:0002040)1.46253295
194Mildly elevated creatine phosphokinase (HP:0008180)1.45811102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.43713756
2EPHA33.37866517
3INSRR3.29593367
4ACVR1B2.77566250
5WNK32.68464092
6MAP3K42.53521315
7MKNK22.37013337
8NTRK32.34963160
9TNIK2.34702954
10MAP3K22.32194384
11FER2.22405836
12TRIM282.12043371
13MAP2K42.09575626
14MAP2K71.99826587
15STK38L1.99096299
16LATS11.96546752
17MST1R1.96351369
18EPHB21.95216243
19FGFR41.89481216
20DDR21.76752632
21PNCK1.74366659
22GRK11.73060631
23FLT31.68950366
24ERBB41.68158041
25PTK61.63402464
26MST41.58884185
27FGFR31.58859345
28MARK11.58700787
29BRSK21.54822900
30MKNK11.54265365
31STK391.53912824
32ADRBK21.42560377
33MAP4K21.42227361
34MYLK1.42022425
35ERBB31.40279650
36SIK11.37702296
37PDK21.37320376
38BMPR1B1.37227344
39TRIB31.31394140
40MAP3K141.28825449
41TGFBR21.28412177
42PRKD31.26699049
43KSR21.24758630
44TIE11.21509629
45DAPK21.18193994
46PAK31.15931825
47OXSR11.15513862
48PINK11.15404299
49PIK3CG1.14626235
50FGFR21.12451381
51RET1.11616584
52WEE11.10113777
53STK31.08688818
54EIF2AK31.07755667
55IRAK31.07587763
56NEK91.06316930
57CAMKK11.05733890
58MAP3K11.05440141
59MAP3K31.03898039
60NTRK11.02618571
61ZAK1.01659702
62JAK11.00793772
63PDGFRA0.99600871
64NLK0.99191725
65CAMKK20.98985669
66ABL20.96559357
67PLK40.94526125
68IRAK10.94281905
69MET0.94234080
70AKT30.93865190
71EPHB10.91766654
72ADRBK10.91287233
73PAK60.91093743
74TAOK30.90485455
75PRKCE0.88846397
76SGK20.85990572
77JAK20.85332630
78RIPK10.84048868
79BMX0.83674559
80MAP2K10.81567062
81ROCK10.81054940
82OBSCN0.80943438
83ERN10.80914432
84BCR0.80835611
85PRKCH0.78801682
86SGK30.77616382
87PLK30.77592759
88MAP3K120.76285731
89PTK20.74889697
90MAPKAPK30.73869339
91MAPKAPK50.72137159
92TTN0.69871953
93MAP3K90.68293031
94FGFR10.65629966
95NUAK10.63154811
96CSNK1G10.63074989
97GRK70.61845597
98TGFBR10.59558971
99KSR10.59412396
100MINK10.58938297
101GSK3A0.58885348
102HIPK20.58779166
103WNK40.58479055
104LATS20.57644590
105STK240.56976212
106PKN20.56926744
107CASK0.56753401
108PHKG20.56616440
109PHKG10.56616440
110PTK2B0.55789373
111PRKAA10.53871693
112NEK10.53700607
113MELK0.53150200
114NTRK20.52686674
115CDK50.50578220
116DYRK1B0.50124860
117CAMK2A0.50084423
118PRKACG0.49515563
119MUSK0.49181126
120PRKAA20.48869266
121PRKCZ0.48866710
122DMPK0.48079087
123PBK0.47748975
124SGK10.46877199
125LIMK10.46332380
126PIK3CA0.45429039
127PRKCG0.45396457
128PLK20.45393153
129CSNK1G20.44848159
130PAK20.43958076
131TRPM70.43760884
132RPS6KB10.43594183
133MAPK130.43118367
134CAMK1G0.43106822
135MOS0.42639544
136PDGFRB0.41866622
137IGF1R0.40332024
138CDK90.40284428
139CDK60.39942189
140RPS6KA20.39547967
141TNK20.39477351
142CAMK1D0.39056598
143EPHA40.38328640
144ERBB20.38313734
145SGK4940.37675535
146SGK2230.37675535
147CAMK2D0.36862413
148CSNK1A1L0.35630363
149BMPR20.35606401
150STK100.34774045
151STK160.33144268
152TEC0.32706856
153ABL10.31624661
154PRKG10.30028826
155ATM0.28128422
156TLK10.27027372

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.16792214
2Nitrogen metabolism_Homo sapiens_hsa009102.74477707
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38404869
4Arginine biosynthesis_Homo sapiens_hsa002202.35364945
5Complement and coagulation cascades_Homo sapiens_hsa046102.32936422
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.25655215
7ECM-receptor interaction_Homo sapiens_hsa045122.20935727
8Protein export_Homo sapiens_hsa030602.18771376
9Tryptophan metabolism_Homo sapiens_hsa003802.12713028
10TGF-beta signaling pathway_Homo sapiens_hsa043501.93767070
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90549950
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.87109216
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86738360
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75983960
15Histidine metabolism_Homo sapiens_hsa003401.73333080
16Starch and sucrose metabolism_Homo sapiens_hsa005001.72738939
17Butanoate metabolism_Homo sapiens_hsa006501.67310145
18Sulfur metabolism_Homo sapiens_hsa009201.64721741
19Phototransduction_Homo sapiens_hsa047441.63320456
20Phenylalanine metabolism_Homo sapiens_hsa003601.62585543
21Hedgehog signaling pathway_Homo sapiens_hsa043401.62531099
22Circadian rhythm_Homo sapiens_hsa047101.59532823
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52956547
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49780404
25Basal cell carcinoma_Homo sapiens_hsa052171.42202569
26Linoleic acid metabolism_Homo sapiens_hsa005911.41170382
27Basal transcription factors_Homo sapiens_hsa030221.40711927
28Olfactory transduction_Homo sapiens_hsa047401.39120703
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.38482088
30Protein digestion and absorption_Homo sapiens_hsa049741.37284885
31Fatty acid degradation_Homo sapiens_hsa000711.36340103
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36175716
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.32900559
34Bile secretion_Homo sapiens_hsa049761.32099718
35Tyrosine metabolism_Homo sapiens_hsa003501.31353073
36Hippo signaling pathway_Homo sapiens_hsa043901.30454998
37beta-Alanine metabolism_Homo sapiens_hsa004101.30326628
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29978778
39Ether lipid metabolism_Homo sapiens_hsa005651.24066535
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23128553
41PPAR signaling pathway_Homo sapiens_hsa033201.21063985
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20764731
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19661545
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18573866
45Staphylococcus aureus infection_Homo sapiens_hsa051501.17785678
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13686582
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11986729
48Peroxisome_Homo sapiens_hsa041461.09656958
49Non-homologous end-joining_Homo sapiens_hsa034501.09119709
50Insulin secretion_Homo sapiens_hsa049111.08456612
51Type II diabetes mellitus_Homo sapiens_hsa049301.07397906
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05029425
53Chemical carcinogenesis_Homo sapiens_hsa052041.04635962
54Retinol metabolism_Homo sapiens_hsa008301.02911422
55Tight junction_Homo sapiens_hsa045301.01360909
56Steroid biosynthesis_Homo sapiens_hsa001000.96904045
57Adherens junction_Homo sapiens_hsa045200.96193673
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95437844
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91486895
60Melanoma_Homo sapiens_hsa052180.90488022
61Homologous recombination_Homo sapiens_hsa034400.85820360
62Fatty acid metabolism_Homo sapiens_hsa012120.85690314
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85148145
64Insulin resistance_Homo sapiens_hsa049310.84139263
65Wnt signaling pathway_Homo sapiens_hsa043100.81260664
66Salivary secretion_Homo sapiens_hsa049700.80390137
67ABC transporters_Homo sapiens_hsa020100.79819398
68Sphingolipid metabolism_Homo sapiens_hsa006000.78631817
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.78354880
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77489921
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77143974
72Mineral absorption_Homo sapiens_hsa049780.75839286
73Fanconi anemia pathway_Homo sapiens_hsa034600.73995611
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73327105
75Dorso-ventral axis formation_Homo sapiens_hsa043200.71202353
76Prion diseases_Homo sapiens_hsa050200.70172309
77Calcium signaling pathway_Homo sapiens_hsa040200.69463098
78Vitamin B6 metabolism_Homo sapiens_hsa007500.68931074
79Glucagon signaling pathway_Homo sapiens_hsa049220.68696190
80Ovarian steroidogenesis_Homo sapiens_hsa049130.66361751
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65896366
82Regulation of autophagy_Homo sapiens_hsa041400.65489975
83Fatty acid biosynthesis_Homo sapiens_hsa000610.65117371
84Synaptic vesicle cycle_Homo sapiens_hsa047210.65110413
85Caffeine metabolism_Homo sapiens_hsa002320.64925284
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64174197
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63841236
88GABAergic synapse_Homo sapiens_hsa047270.62567931
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62454267
90Cocaine addiction_Homo sapiens_hsa050300.61679330
91RNA degradation_Homo sapiens_hsa030180.61322687
92Taste transduction_Homo sapiens_hsa047420.60914837
93p53 signaling pathway_Homo sapiens_hsa041150.60845694
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60513531
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58245648
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.58199537
97One carbon pool by folate_Homo sapiens_hsa006700.57976627
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56707977
99Glycerolipid metabolism_Homo sapiens_hsa005610.56267690
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55853630
101Long-term potentiation_Homo sapiens_hsa047200.55332916
102Vibrio cholerae infection_Homo sapiens_hsa051100.55113384
103cAMP signaling pathway_Homo sapiens_hsa040240.53699288
104Fat digestion and absorption_Homo sapiens_hsa049750.53332255
105Lysine degradation_Homo sapiens_hsa003100.52720644
106Collecting duct acid secretion_Homo sapiens_hsa049660.52471396
107Pyruvate metabolism_Homo sapiens_hsa006200.52436814
108Amphetamine addiction_Homo sapiens_hsa050310.52242740
109GnRH signaling pathway_Homo sapiens_hsa049120.52067318
110Selenocompound metabolism_Homo sapiens_hsa004500.51896374
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51879762
112Renin secretion_Homo sapiens_hsa049240.50937131
113Thyroid hormone synthesis_Homo sapiens_hsa049180.50866493
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49279045
115Pancreatic secretion_Homo sapiens_hsa049720.49063988
116Phagosome_Homo sapiens_hsa041450.48718948
117Glioma_Homo sapiens_hsa052140.48605137
118Prolactin signaling pathway_Homo sapiens_hsa049170.48232023
119Amoebiasis_Homo sapiens_hsa051460.48127512
120Cholinergic synapse_Homo sapiens_hsa047250.47831879
121Estrogen signaling pathway_Homo sapiens_hsa049150.47136128
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47002098
123Long-term depression_Homo sapiens_hsa047300.44943305
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44842473
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44322433
126Melanogenesis_Homo sapiens_hsa049160.43661643
127Bladder cancer_Homo sapiens_hsa052190.43441226
128Oxytocin signaling pathway_Homo sapiens_hsa049210.43321862
129Arachidonic acid metabolism_Homo sapiens_hsa005900.43131801
130Propanoate metabolism_Homo sapiens_hsa006400.43112857
131Circadian entrainment_Homo sapiens_hsa047130.42935243
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42886239
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42569475
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42471012
135Insulin signaling pathway_Homo sapiens_hsa049100.42389633
136Lysosome_Homo sapiens_hsa041420.40890657
137Serotonergic synapse_Homo sapiens_hsa047260.40216693
138Dilated cardiomyopathy_Homo sapiens_hsa054140.39973658
139Type I diabetes mellitus_Homo sapiens_hsa049400.39467273
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39419148
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39398144
142Arginine and proline metabolism_Homo sapiens_hsa003300.39264358
143Proteoglycans in cancer_Homo sapiens_hsa052050.38707581
144Dopaminergic synapse_Homo sapiens_hsa047280.38689183
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38163579
146Focal adhesion_Homo sapiens_hsa045100.37863483
147Nicotine addiction_Homo sapiens_hsa050330.37582988
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37435394
149Glutamatergic synapse_Homo sapiens_hsa047240.37179938
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.36863644
151ErbB signaling pathway_Homo sapiens_hsa040120.36460003

Most similar genes based on co-expression Upload to Enrichr

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