RNF216

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.89980410
2nuclear pore complex assembly (GO:0051292)4.76706144
3nuclear pore organization (GO:0006999)4.68358274
4spliceosomal tri-snRNP complex assembly (GO:0000244)4.48225747
5synaptonemal complex assembly (GO:0007130)4.46148566
6regulation of histone H3-K27 methylation (GO:0061085)4.41043904
7positive regulation of gamma-delta T cell activation (GO:0046645)4.34701898
8negative thymic T cell selection (GO:0045060)4.13517879
9pore complex assembly (GO:0046931)4.12915698
10mitotic sister chromatid cohesion (GO:0007064)4.08135614
11negative T cell selection (GO:0043383)4.06634938
12protein localization to kinetochore (GO:0034501)4.04670228
13histone H3-K4 trimethylation (GO:0080182)3.88544376
14synaptonemal complex organization (GO:0070193)3.88250466
15hemidesmosome assembly (GO:0031581)3.83434915
16gene silencing by RNA (GO:0031047)3.80057443
17protein localization to chromosome, centromeric region (GO:0071459)3.75165697
18regulation of B cell receptor signaling pathway (GO:0050855)3.63091886
19RNA localization (GO:0006403)3.61850327
20protein K48-linked deubiquitination (GO:0071108)3.60672880
21mitotic nuclear envelope disassembly (GO:0007077)3.60208486
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59288247
23negative regulation of cell killing (GO:0031342)3.59288247
24regulation of spindle organization (GO:0090224)3.56443885
25mitotic chromosome condensation (GO:0007076)3.55418624
26histone H3-K36 demethylation (GO:0070544)3.55231071
27regulation of RNA export from nucleus (GO:0046831)3.54022580
28histone H3-K4 methylation (GO:0051568)3.53320390
29heterochromatin organization (GO:0070828)3.53319365
30Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53276699
31response to interleukin-15 (GO:0070672)3.51863373
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50880994
33positive regulation of granulocyte differentiation (GO:0030854)3.50689244
34protein localization to chromosome (GO:0034502)3.49566162
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49487884
36regulation of meiosis I (GO:0060631)3.46395749
37DNA methylation involved in gamete generation (GO:0043046)3.46082975
38nuclear envelope disassembly (GO:0051081)3.43915936
39membrane disassembly (GO:0030397)3.43915936
40male meiosis (GO:0007140)3.41401891
41regulation of telomere maintenance via telomerase (GO:0032210)3.40134715
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39114273
43thymic T cell selection (GO:0045061)3.37469517
44monoubiquitinated protein deubiquitination (GO:0035520)3.32481148
45B cell receptor signaling pathway (GO:0050853)3.31082644
46histone H3-K9 demethylation (GO:0033169)3.30944382
47peptidyl-lysine trimethylation (GO:0018023)3.27550720
48mitotic metaphase plate congression (GO:0007080)3.25241455
49regulation of mitotic spindle organization (GO:0060236)3.23907549
50pre-miRNA processing (GO:0031054)3.20307626
51positive regulation of chromosome segregation (GO:0051984)3.18204291
52positive thymic T cell selection (GO:0045059)3.14576037
53gene silencing (GO:0016458)3.13663481
54T cell selection (GO:0045058)3.12321487
55positive T cell selection (GO:0043368)3.10826116
56regulation of histone H3-K9 methylation (GO:0051570)3.10462319
57chromatin assembly (GO:0031497)3.07918301
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04750369
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04750369
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.04750369
61regulation of nucleobase-containing compound transport (GO:0032239)3.03032492
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02536150
63retrograde transport, vesicle recycling within Golgi (GO:0000301)3.00633103
64cellular response to interleukin-15 (GO:0071350)3.00323728
65histone H2A monoubiquitination (GO:0035518)2.99861033
66leukocyte aggregation (GO:0070486)2.99622298
67meiotic nuclear division (GO:0007126)2.99280305
68negative regulation of histone methylation (GO:0031061)2.96146437
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.95118314
70attachment of spindle microtubules to kinetochore (GO:0008608)2.93314312
71metaphase plate congression (GO:0051310)2.93183315
72regulation of histone methylation (GO:0031060)2.92556486
73NLS-bearing protein import into nucleus (GO:0006607)2.92306956
74regulation of gamma-delta T cell differentiation (GO:0045586)2.91687220
75positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91681423
76DNA alkylation (GO:0006305)2.91600929
77DNA methylation (GO:0006306)2.91600929
78actin nucleation (GO:0045010)2.91090964
79protein K63-linked deubiquitination (GO:0070536)2.90590673
80protein targeting to Golgi (GO:0000042)2.89398331
81establishment of protein localization to Golgi (GO:0072600)2.89282304
82chromosome organization involved in meiosis (GO:0070192)2.88506653
83histone H3-K9 methylation (GO:0051567)2.86103721
84histone H4-K12 acetylation (GO:0043983)2.85775264
85nuclear envelope organization (GO:0006998)2.85426396
86cellular response to ethanol (GO:0071361)2.85213438
87meiotic chromosome segregation (GO:0045132)2.84492541
88chromosome condensation (GO:0030261)2.81811333
89regulation of gamma-delta T cell activation (GO:0046643)2.81254852
90DNA packaging (GO:0006323)2.80867594
91regulation of sister chromatid cohesion (GO:0007063)2.80589362
92response to muramyl dipeptide (GO:0032495)2.79265989
93DNA damage induced protein phosphorylation (GO:0006975)2.78678993
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76694025
95regulation of chromosome segregation (GO:0051983)2.76597298
96positive regulation by symbiont of host defense response (GO:0052509)2.75838032
97modulation by symbiont of host defense response (GO:0052031)2.75838032
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75838032
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75838032
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.75838032
101modulation by symbiont of host immune response (GO:0052553)2.75838032
102cell-substrate junction assembly (GO:0007044)2.74078574
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73792923
104sister chromatid cohesion (GO:0007062)2.73446662
105histone mRNA catabolic process (GO:0071044)2.73064914
106histone lysine demethylation (GO:0070076)2.69995477
107antigen processing and presentation of endogenous antigen (GO:0019883)2.69759215
108histone lysine methylation (GO:0034968)2.67353615
109positive regulation of SMAD protein import into nucleus (GO:0060391)2.66711478
110DNA replication checkpoint (GO:0000076)2.63945567
111histone deubiquitination (GO:0016578)2.63026627
112peptidyl-lysine dimethylation (GO:0018027)2.62155823
113spindle checkpoint (GO:0031577)2.61695991
114mitotic spindle checkpoint (GO:0071174)2.60074133
115spindle assembly (GO:0051225)2.59409941
116negative regulation of chromosome segregation (GO:0051985)2.59356981
117histone demethylation (GO:0016577)2.59121794
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58940910
119activated T cell proliferation (GO:0050798)2.58790690
120spindle assembly involved in mitosis (GO:0090307)2.57174546
121tolerance induction (GO:0002507)2.57169313
122histone H4-K16 acetylation (GO:0043984)2.55914875
123inner cell mass cell proliferation (GO:0001833)2.55641677
124RNA stabilization (GO:0043489)2.55178885
125mRNA stabilization (GO:0048255)2.55178885
126nucleus organization (GO:0006997)2.54738088
127histone H3-K9 modification (GO:0061647)2.54388860
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54037705
129chromatin assembly or disassembly (GO:0006333)2.53990574
130mitotic G1 DNA damage checkpoint (GO:0031571)2.53372532
131meiotic cell cycle process (GO:1903046)2.53310473
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53099478
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53006183
134regulation of granulocyte differentiation (GO:0030852)2.52353400
135maintenance of protein location in nucleus (GO:0051457)2.51336556
136peptidyl-lysine methylation (GO:0018022)2.51257359
137mitotic sister chromatid segregation (GO:0000070)2.50480370
138negative regulation of DNA repair (GO:0045738)2.50205418
139DNA replication-dependent nucleosome assembly (GO:0006335)2.50065561
140DNA replication-dependent nucleosome organization (GO:0034723)2.50065561
141mitotic spindle assembly checkpoint (GO:0007094)2.49951229
142negative regulation of T cell mediated immunity (GO:0002710)2.49949094
143spindle assembly checkpoint (GO:0071173)2.48720127
144mannose metabolic process (GO:0006013)2.48668120
145protein K6-linked ubiquitination (GO:0085020)2.47903225
146sister chromatid segregation (GO:0000819)2.47304240
147male meiosis I (GO:0007141)2.47135062
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.46399598
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46399598
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46399598
151negative regulation of sister chromatid segregation (GO:0033046)2.46399598
152reciprocal DNA recombination (GO:0035825)2.46143917
153reciprocal meiotic recombination (GO:0007131)2.46143917
154regulation of interferon-beta biosynthetic process (GO:0045357)2.45221675
155regulation of extracellular matrix disassembly (GO:0010715)2.44668347
156seminiferous tubule development (GO:0072520)2.44177074
157DNA synthesis involved in DNA repair (GO:0000731)2.43402288
158regulation of defense response to virus by virus (GO:0050690)2.42531225
159dosage compensation (GO:0007549)2.42340524
160negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41568704
161germ cell migration (GO:0008354)2.41436636
162regulation of mitotic sister chromatid separation (GO:0010965)2.40725142
163regulation of mitotic sister chromatid segregation (GO:0033047)2.40725142
164regulation of sister chromatid segregation (GO:0033045)2.40725142
165nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.40638412
166negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.40423136
167oocyte maturation (GO:0001556)2.40322862
168negative regulation of viral release from host cell (GO:1902187)2.39802545
169microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.39046620
170DNA methylation or demethylation (GO:0044728)2.38533953
171regulation of histone H3-K4 methylation (GO:0051569)2.38486649
172centrosome localization (GO:0051642)2.35810312
173activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35123447
174intra-Golgi vesicle-mediated transport (GO:0006891)2.34644306
175protein demethylation (GO:0006482)2.34167810
176protein dealkylation (GO:0008214)2.34167810
177negative regulation of erythrocyte differentiation (GO:0045647)2.33148160
178snRNA metabolic process (GO:0016073)2.31722696
179response to laminar fluid shear stress (GO:0034616)2.31129322
180protein export from nucleus (GO:0006611)2.30674161
181phosphatidylinositol dephosphorylation (GO:0046856)2.30238803
182negative regulation of skeletal muscle tissue development (GO:0048642)2.29593576
183T cell migration (GO:0072678)2.29181148
184regulation of protein polyubiquitination (GO:1902914)2.28188853
185negative regulation of cAMP-mediated signaling (GO:0043951)2.28073889
186hepatocyte apoptotic process (GO:0097284)2.27553481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42796022
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.10004356
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.58426538
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.71978566
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65110845
6MYC_22102868_ChIP-Seq_BL_Human3.00238337
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93697318
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79271945
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77868494
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60668712
11TCF7_22412390_ChIP-Seq_EML_Mouse2.06785293
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01336361
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.00759489
14RUNX_20019798_ChIP-Seq_JUKART_Human2.00694227
15VDR_21846776_ChIP-Seq_THP-1_Human1.96014100
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93702426
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85907756
18AR_21909140_ChIP-Seq_LNCAP_Human1.80938968
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.78888401
20CIITA_25753668_ChIP-Seq_RAJI_Human1.74296179
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.70737718
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69373616
23KDM2B_26808549_Chip-Seq_DND41_Human1.67739358
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.54752459
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54692714
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52782336
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52309029
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49594353
29* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49343440
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.49148989
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.48899799
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48145415
33MAF_26560356_Chip-Seq_TH1_Human1.47154178
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45023223
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40114042
36GATA1_22025678_ChIP-Seq_K562_Human1.38672575
37SCL_19346495_ChIP-Seq_HPC-7_Human1.37674926
38NCOR1_26117541_ChIP-Seq_K562_Human1.37495744
39KDM5A_27292631_Chip-Seq_BREAST_Human1.37279287
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36993198
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35707262
42* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35305683
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34914498
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34438776
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.34232295
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.33988653
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33557649
48ZNF263_19887448_ChIP-Seq_K562_Human1.32020981
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31887165
50UTX_26944678_Chip-Seq_JUKART_Human1.31814810
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30806335
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30406822
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29562131
54SPI1_23547873_ChIP-Seq_NB4_Human1.28388379
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28123709
56MYB_26560356_Chip-Seq_TH1_Human1.27180384
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.26728179
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26363930
59GATA3_27048872_Chip-Seq_THYMUS_Human1.25692249
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.24805716
61TFEB_21752829_ChIP-Seq_HELA_Human1.24626160
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24507506
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24402509
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.23719956
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23196643
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.23190933
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23123909
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21985058
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21614413
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21115284
71VDR_24763502_ChIP-Seq_THP-1_Human1.20367575
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20182231
73* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20121814
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19843519
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19843519
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19843519
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19708651
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19372080
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.19175175
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18980272
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18809852
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18791536
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18552998
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17305051
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16217853
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14700733
87* SPI1_23127762_ChIP-Seq_K562_Human1.14577835
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14003085
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13760084
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13756134
91* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13010435
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.12251003
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11352622
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.10883913
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09691837
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09691837
97PU_27001747_Chip-Seq_BMDM_Mouse1.09285413
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09183713
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08428096
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08014584
101MYB_26560356_Chip-Seq_TH2_Human1.07439654
102* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06609139
103* BRD4_25478319_ChIP-Seq_HGPS_Human1.05575474
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05514345
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05481998
106ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04488201
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03616764
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02996520
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02658010
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02456376
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02050437
112ATF3_27146783_Chip-Seq_COLON_Human1.01498140
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01367001
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99883263
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99787848
116* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99499881
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.98257341
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97685725
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96665996
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96459272
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96321099
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96114924
123MAF_26560356_Chip-Seq_TH2_Human0.95626368
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95143326
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94894325
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94169305
127GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94078665
128TP53_22127205_ChIP-Seq_IMR90_Human0.92908136
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92693183
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91861402
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91560330
132XRN2_22483619_ChIP-Seq_HELA_Human0.89882103
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89879200
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89860970
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88681400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.79686127
2MP0008877_abnormal_DNA_methylation3.44735731
3MP0009278_abnormal_bone_marrow3.32220144
4MP0003111_abnormal_nucleus_morphology2.97724861
5MP0010352_gastrointestinal_tract_polyps2.94111856
6MP0008057_abnormal_DNA_replication2.62820489
7MP0003693_abnormal_embryo_hatching2.62388268
8MP0010094_abnormal_chromosome_stability2.60264889
9MP0005076_abnormal_cell_differentiation2.53860874
10MP0003077_abnormal_cell_cycle2.37380683
11MP0003172_abnormal_lysosome_physiology2.35084835
12MP0010307_abnormal_tumor_latency2.34666444
13MP0008260_abnormal_autophagy2.33518822
14MP0002009_preneoplasia2.26182075
15MP0003436_decreased_susceptibility_to2.19282762
16MP0003303_peritoneal_inflammation2.15651175
17MP0005397_hematopoietic_system_phenotyp2.13198427
18MP0001545_abnormal_hematopoietic_system2.13198427
19MP0008995_early_reproductive_senescence2.13059298
20MP0002396_abnormal_hematopoietic_system2.08690651
21MP0005257_abnormal_intraocular_pressure2.02283738
22MP0003045_fibrosis1.98958319
23MP0008007_abnormal_cellular_replicative1.98918750
24MP0004957_abnormal_blastocyst_morpholog1.93095061
25MP0004808_abnormal_hematopoietic_stem1.92357182
26MP0000569_abnormal_digit_pigmentation1.87319991
27MP0008438_abnormal_cutaneous_collagen1.84800925
28MP0003123_paternal_imprinting1.83099851
29MP0003705_abnormal_hypodermis_morpholog1.75886870
30MP0005451_abnormal_body_composition1.73341666
31MP0000751_myopathy1.72740061
32MP0000749_muscle_degeneration1.71411325
33MP0002269_muscular_atrophy1.67997486
34MP0002332_abnormal_exercise_endurance1.66329527
35MP0008058_abnormal_DNA_repair1.64549996
36MP0002877_abnormal_melanocyte_morpholog1.61635856
37MP0003786_premature_aging1.59874641
38MP0001730_embryonic_growth_arrest1.59673411
39MP0004381_abnormal_hair_follicle1.58368024
40MP0000350_abnormal_cell_proliferation1.57329765
41MP0005058_abnormal_lysosome_morphology1.55118129
42MP0002006_tumorigenesis1.48956006
43MP0005408_hypopigmentation1.48477002
44MP0005387_immune_system_phenotype1.47931571
45MP0001790_abnormal_immune_system1.47931571
46MP0003300_gastrointestinal_ulcer1.47139272
47MP0005380_embryogenesis_phenotype1.46407286
48MP0001672_abnormal_embryogenesis/_devel1.46407286
49MP0005670_abnormal_white_adipose1.45441311
50MP0002210_abnormal_sex_determination1.43099716
51MP0003984_embryonic_growth_retardation1.40129271
52MP0001929_abnormal_gametogenesis1.37334519
53MP0002088_abnormal_embryonic_growth/wei1.36819508
54MP0001958_emphysema1.36277198
55MP0002419_abnormal_innate_immunity1.35662258
56MP0002086_abnormal_extraembryonic_tissu1.34421685
57MP0004197_abnormal_fetal_growth/weight/1.32145147
58MP0001243_abnormal_dermal_layer1.32127719
59MP0005310_abnormal_salivary_gland1.30556272
60MP0001348_abnormal_lacrimal_gland1.30000009
61MP0000358_abnormal_cell_content/1.29517127
62MP0000490_abnormal_crypts_of1.29119297
63MP0005377_hearing/vestibular/ear_phenot1.28746390
64MP0003878_abnormal_ear_physiology1.28746390
65MP0003828_pulmonary_edema1.28031218
66MP0001697_abnormal_embryo_size1.26056273
67MP0003566_abnormal_cell_adhesion1.25606572
68MP0005000_abnormal_immune_tolerance1.25258348
69MP0006035_abnormal_mitochondrial_morpho1.24812181
70MP0000733_abnormal_muscle_development1.24507925
71MP0001145_abnormal_male_reproductive1.22286823
72MP0003279_aneurysm1.19390524
73MP0005464_abnormal_platelet_physiology1.19186232
74MP0001873_stomach_inflammation1.19044131
75MP0005075_abnormal_melanosome_morpholog1.18680501
76MP0002084_abnormal_developmental_patter1.17584056
77MP0004233_abnormal_muscle_weight1.17546061
78MP0002085_abnormal_embryonic_tissue1.15963679
79MP0002080_prenatal_lethality1.13399639
80MP0003866_abnormal_defecation1.12210031
81MP0000313_abnormal_cell_death1.09724601
82MP0008961_abnormal_basal_metabolism1.07985266
83MP0001835_abnormal_antigen_presentation1.07956319
84MP0002398_abnormal_bone_marrow1.07393603
85MP0002060_abnormal_skin_morphology1.06828032
86MP0000653_abnormal_sex_gland1.05453876
87MP0002019_abnormal_tumor_incidence1.05325822
88MP0002254_reproductive_system_inflammat1.03042063
89MP0009840_abnormal_foam_cell1.02994272
90MP0002168_other_aberrant_phenotype1.02590028
91MP0001851_eye_inflammation1.01971734
92MP0001800_abnormal_humoral_immune0.99617619
93MP0001849_ear_inflammation0.99468148
94MP0009672_abnormal_birth_weight0.98794797
95MP0003567_abnormal_fetal_cardiomyocyte0.97970725
96MP0000371_diluted_coat_color0.96977348
97MP0003191_abnormal_cellular_cholesterol0.94751301
98MP0005409_darkened_coat_color0.94014069
99MP0002452_abnormal_antigen_presenting0.93750662
100MP0001853_heart_inflammation0.93243334
101MP0005025_abnormal_response_to0.92554574
102MP0004264_abnormal_extraembryonic_tissu0.91718286
103MP0004510_myositis0.91319559
104MP0005621_abnormal_cell_physiology0.90740901
105MP0000689_abnormal_spleen_morphology0.90371414
106MP0003941_abnormal_skin_development0.89104427
107MP0002722_abnormal_immune_system0.88676548
108MP0003950_abnormal_plasma_membrane0.88103344
109MP0009333_abnormal_splenocyte_physiolog0.87655134
110MP0000703_abnormal_thymus_morphology0.87490745
111MP0003656_abnormal_erythrocyte_physiolo0.86730411
112MP0003091_abnormal_cell_migration0.86536765
113MP0000015_abnormal_ear_pigmentation0.86180189
114MP0001299_abnormal_eye_distance/0.85841783
115MP0003115_abnormal_respiratory_system0.84100546
116MP0009703_decreased_birth_body0.84025782
117MP0004185_abnormal_adipocyte_glucose0.83956557
118MP0010155_abnormal_intestine_physiology0.83947061
119MP0001533_abnormal_skeleton_physiology0.83581234
120MP0003698_abnormal_male_reproductive0.82773417
121MP0003121_genomic_imprinting0.82613451
122MP0005023_abnormal_wound_healing0.82439869
123MP0000759_abnormal_skeletal_muscle0.81270627
124MP0001915_intracranial_hemorrhage0.79857087
125MP0000465_gastrointestinal_hemorrhage0.78399414
126MP0000716_abnormal_immune_system0.77945900
127MP0005671_abnormal_response_to0.77856016
128MP0002429_abnormal_blood_cell0.77567898
129MP0002928_abnormal_bile_duct0.77310344
130MP0002653_abnormal_ependyma_morphology0.76331693
131MP0001819_abnormal_immune_cell0.75625539
132MP0003448_altered_tumor_morphology0.75567107
133MP0004947_skin_inflammation0.75316467
134MP0002420_abnormal_adaptive_immunity0.75019590
135MP0002723_abnormal_immune_serum0.74617002
136MP0002925_abnormal_cardiovascular_devel0.74073882
137MP0003119_abnormal_digestive_system0.73953309
138MP0000428_abnormal_craniofacial_morphol0.73918529
139MP0000767_abnormal_smooth_muscle0.72321495
140MP0000685_abnormal_immune_system0.72175943
141MP0005384_cellular_phenotype0.71132213
142MP0002166_altered_tumor_susceptibility0.70300242
143MP0002405_respiratory_system_inflammati0.70033344
144MP0003453_abnormal_keratinocyte_physiol0.69921933
145MP0001119_abnormal_female_reproductive0.68897723
146MP0010630_abnormal_cardiac_muscle0.68743114

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)5.33948826
2Abnormality of the fingertips (HP:0001211)3.40606531
3Neonatal respiratory distress (HP:0002643)3.34842204
4Thick nail (HP:0001805)3.31778933
5Volvulus (HP:0002580)3.14228620
6Milia (HP:0001056)3.01817574
7Upper limb amyotrophy (HP:0009129)2.96239078
8Distal upper limb amyotrophy (HP:0007149)2.96239078
9Alopecia of scalp (HP:0002293)2.96001374
10Cerebral aneurysm (HP:0004944)2.89380334
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85033253
12Fragile skin (HP:0001030)2.70846319
13Long eyelashes (HP:0000527)2.70819503
14Impulsivity (HP:0100710)2.69692076
15Eczematoid dermatitis (HP:0000976)2.67372134
16Spondylolisthesis (HP:0003302)2.64000153
17Chromsome breakage (HP:0040012)2.55164339
18Hematochezia (HP:0002573)2.48545377
19Prominent nose (HP:0000448)2.46726742
20Urethral obstruction (HP:0000796)2.44843464
21Colon cancer (HP:0003003)2.40985028
22Astrocytoma (HP:0009592)2.36157145
23Abnormality of the astrocytes (HP:0100707)2.36157145
24Male infertility (HP:0003251)2.35776058
25Distal lower limb amyotrophy (HP:0008944)2.35466858
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.33605878
27Ectopic kidney (HP:0000086)2.33188179
28Abnormality of DNA repair (HP:0003254)2.28116614
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27365681
30Increased nuchal translucency (HP:0010880)2.25697233
31Broad face (HP:0000283)2.23892884
32Narrow palate (HP:0000189)2.23739421
33Facial hemangioma (HP:0000329)2.22555405
34Glioma (HP:0009733)2.21646274
35Basal cell carcinoma (HP:0002671)2.20359677
36Deviation of the thumb (HP:0009603)2.19901824
37Spinal muscular atrophy (HP:0007269)2.19343244
38Fatigue (HP:0012378)2.18806007
39Proximal placement of thumb (HP:0009623)2.18761966
40Syringomyelia (HP:0003396)2.17806963
41Spinal cord lesions (HP:0100561)2.17806963
42Neoplasm of the adrenal cortex (HP:0100641)2.17392207
43Recurrent fungal infections (HP:0002841)2.16294557
44Ependymoma (HP:0002888)2.15698948
45Ankle contracture (HP:0006466)2.15067873
46Prostate neoplasm (HP:0100787)2.14797927
47T lymphocytopenia (HP:0005403)2.14410472
48Abnormal spermatogenesis (HP:0008669)2.12988680
49Azoospermia (HP:0000027)2.11984358
50Rectal prolapse (HP:0002035)2.11893034
51Difficulty climbing stairs (HP:0003551)2.10785491
52Selective tooth agenesis (HP:0001592)2.08415325
53Colitis (HP:0002583)2.06696723
54Keratitis (HP:0000491)2.05644919
55Absent frontal sinuses (HP:0002688)2.05313170
56Insomnia (HP:0100785)2.05053960
57Metaphyseal cupping (HP:0003021)2.04026969
58Heterotopia (HP:0002282)2.03513478
59Short chin (HP:0000331)2.03187169
60Dilatation of the ascending aorta (HP:0005111)2.02997754
61Cellulitis (HP:0100658)2.01810991
62Recurrent cutaneous fungal infections (HP:0011370)2.01514042
63Chronic mucocutaneous candidiasis (HP:0002728)2.01514042
64Gastrointestinal carcinoma (HP:0002672)2.00803765
65Malignant gastrointestinal tract tumors (HP:0006749)2.00803765
66Recurrent viral infections (HP:0004429)2.00461480
67Deep palmar crease (HP:0006191)1.99739944
68Pustule (HP:0200039)1.99720057
69Subacute progressive viral hepatitis (HP:0006572)1.99065042
70Dislocated radial head (HP:0003083)1.98746831
71Ulnar bowing (HP:0003031)1.98592284
72Enlarged penis (HP:0000040)1.96019663
73Persistence of primary teeth (HP:0006335)1.94840242
74Patellar aplasia (HP:0006443)1.93996236
75Panhypogammaglobulinemia (HP:0003139)1.93973713
76Abnormal foot bone ossification (HP:0010675)1.93888449
77Gastrointestinal inflammation (HP:0004386)1.93812453
78Mitral valve prolapse (HP:0001634)1.93548199
79Long palpebral fissure (HP:0000637)1.92739172
80Aortic dissection (HP:0002647)1.91869209
81Neoplasm of the oral cavity (HP:0100649)1.91009702
82Medulloblastoma (HP:0002885)1.90522486
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.90043925
84Low anterior hairline (HP:0000294)1.89891133
85Inflammation of the large intestine (HP:0002037)1.89746425
86Protrusio acetabuli (HP:0003179)1.89253351
87Premature rupture of membranes (HP:0001788)1.87999160
88Abnormality of the neuromuscular junction (HP:0003398)1.86319310
89Fatigable weakness (HP:0003473)1.86319310
90Glucose intolerance (HP:0000833)1.86096595
91Aplasia/Hypoplasia of the patella (HP:0006498)1.85238869
92Hand muscle atrophy (HP:0009130)1.84820773
93Abnormality of chromosome stability (HP:0003220)1.84781651
94Abnormality of the radial head (HP:0003995)1.84587315
95Stomatitis (HP:0010280)1.83976871
96Prolonged bleeding time (HP:0003010)1.82247287
97Shallow orbits (HP:0000586)1.82163685
98Overlapping toe (HP:0001845)1.81805292
99Sandal gap (HP:0001852)1.81558024
100Abnormal platelet volume (HP:0011876)1.81127477
101Papilloma (HP:0012740)1.80132011
102Verrucae (HP:0200043)1.80132011
103Truncal obesity (HP:0001956)1.79841686
104Nasal polyposis (HP:0100582)1.79826440
105Viral hepatitis (HP:0006562)1.79375323
106Abnormality of the phalanges of the hallux (HP:0010057)1.79304496
107Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78375474
108Short 4th metacarpal (HP:0010044)1.78375474
109Abnormality of the lower motor neuron (HP:0002366)1.78350360
110High pitched voice (HP:0001620)1.78020720
111Conjunctival telangiectasia (HP:0000524)1.76657062
112Hyperacusis (HP:0010780)1.76560049
113Broad palm (HP:0001169)1.75970725
114Mitral regurgitation (HP:0001653)1.75882514
115Albinism (HP:0001022)1.75695988
116Slow saccadic eye movements (HP:0000514)1.75170176
117Obstructive sleep apnea (HP:0002870)1.74683525
118Vertebral compression fractures (HP:0002953)1.74318464
11911 pairs of ribs (HP:0000878)1.74179627
120Acute myeloid leukemia (HP:0004808)1.74031790
121Abnormality of the nasal mucosa (HP:0000433)1.71623487
122Abnormality of T cell number (HP:0011839)1.70450463
123Shawl scrotum (HP:0000049)1.70177771
124Disproportionate tall stature (HP:0001519)1.69725745
125Blepharitis (HP:0000498)1.69485059
126Aortic aneurysm (HP:0004942)1.68677803
127Scanning speech (HP:0002168)1.68104664
128Abnormality of the carotid arteries (HP:0005344)1.67536121
129Entropion (HP:0000621)1.67522991
130Bicuspid aortic valve (HP:0001647)1.65928796
131Abnormality of skeletal muscle fiber size (HP:0012084)1.65622004
132Synophrys (HP:0000664)1.65156673
133Myelodysplasia (HP:0002863)1.65064864
134Meckel diverticulum (HP:0002245)1.64779188
135Pelvic girdle muscle weakness (HP:0003749)1.64734028
136Hypoplastic labia majora (HP:0000059)1.64262668
137Osteolytic defects of the hand bones (HP:0009699)1.63898663
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.63898663
139Abnormality of homocysteine metabolism (HP:0010919)1.63887963
140Homocystinuria (HP:0002156)1.63887963
141Supernumerary ribs (HP:0005815)1.63801161
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63788995
143Recurrent bacterial skin infections (HP:0005406)1.63727888
144Degeneration of anterior horn cells (HP:0002398)1.63134496
145Abnormality of the anterior horn cell (HP:0006802)1.63134496
146Epistaxis (HP:0000421)1.62601237
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.62302177
148Vertebral arch anomaly (HP:0008438)1.61735226
149Joint laxity (HP:0001388)1.61577824
150Abnormality of the thoracic spine (HP:0100711)1.61547050
151Arterial tortuosity (HP:0005116)1.61504376
152Polycythemia (HP:0001901)1.61432858
153Poikiloderma (HP:0001029)1.61256215
154Flat acetabular roof (HP:0003180)1.60964136
155Abnormality of the distal phalanges of the toes (HP:0010182)1.60640819
156Slender long bone (HP:0003100)1.60628391
157Missing ribs (HP:0000921)1.60501611
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60389665
159Atrophic scars (HP:0001075)1.60063885
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.59477273
161Acute lymphatic leukemia (HP:0006721)1.58571440
162Macroorchidism (HP:0000053)1.58359264
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56683382
164Leiomyosarcoma (HP:0100243)1.55388276
165Uterine leiomyosarcoma (HP:0002891)1.55388276
166Thick eyebrow (HP:0000574)1.55363694
167Genu recurvatum (HP:0002816)1.55046601
168Anal stenosis (HP:0002025)1.54823427
169Papillary thyroid carcinoma (HP:0002895)1.54755376
170Abnormality of the ileum (HP:0001549)1.54044736
171Carpal bone hypoplasia (HP:0001498)1.53554585
172Abnormality of the labia majora (HP:0012881)1.52268644
173Biliary tract neoplasm (HP:0100574)1.51503057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.45410096
2NEK23.15881241
3MAP3K102.80222934
4PRPF4B2.65348436
5FGFR42.43045995
6EEF2K2.40200262
7TRIB32.34266998
8ZAP702.07065717
9STK32.00732712
10RIPK11.95592502
11TGFBR21.93564011
12BRD41.91275580
13CDC71.90396507
14EPHB11.87160540
15NEK91.85569449
16CAMK1D1.80635603
17ACVR1B1.78782000
18TTK1.74713953
19JAK11.74015920
20WEE11.72745304
21EIF2AK11.59494795
22BLK1.57873339
23LATS11.53909070
24IRAK41.53844457
25MAP3K131.53357103
26ICK1.51731156
27MAP3K21.51040507
28PKN21.49917685
29CAMK1G1.48185809
30CDK91.47747658
31FGFR31.47675447
32STK101.44850367
33BRSK21.44629890
34MARK21.44482929
35CSF1R1.44171690
36ATR1.43370037
37CDK41.42267222
38BTK1.39553949
39MAP3K141.38361279
40MST1R1.37026105
41TXK1.36127259
42MAP3K31.36013628
43IKBKE1.35841198
44MAPK111.33963385
45NLK1.33099855
46TRPM71.29502985
47HCK1.28754493
48DYRK31.28317400
49CHUK1.25910067
50PIM11.25702958
51RPS6KA41.24459294
52MTOR1.23523923
53MAP2K31.21890677
54MET1.21376146
55PLK11.19783407
56CHEK21.16853506
57MAP2K21.16268068
58MAP3K71.14675664
59SIK11.14110216
60SMG11.13649272
61PRKD21.12393193
62CDK71.11670571
63PTK61.09850438
64ALK1.08106144
65CSK1.05895387
66ERN11.05533691
67MAP3K81.05316912
68RIPK41.04679720
69BUB11.01710242
70CHEK11.00258954
71MARK30.99611179
72PRKD30.98458468
73SIK20.97538692
74PASK0.94209188
75STK40.93788708
76CDC42BPA0.93387296
77DMPK0.92054403
78BMX0.92021198
79AURKB0.91467144
80CDK60.90328386
81EIF2AK30.90224543
82STK380.90147386
83YES10.89178807
84EPHA30.89089431
85MELK0.88149634
86MAP4K10.87641818
87ITK0.87458580
88MKNK20.86850191
89SCYL20.86557927
90LCK0.86164154
91STK240.84255324
92PAK40.83642274
93GRK60.83379542
94ATM0.80059568
95SYK0.78210189
96IKBKB0.78174174
97PDK10.77926799
98SGK30.77094902
99TYK20.76626107
100TTN0.76378444
101TNK20.75374893
102TBK10.75195461
103HIPK20.72106097
104CDK20.71110177
105PDGFRA0.69506007
106NEK60.68940736
107KSR20.68720768
108TGFBR10.68319459
109BRSK10.67557792
110FES0.65970599
111MAP3K60.64833478
112CLK10.64167892
113MAPK100.63733159
114RPS6KB20.63614751
115TEC0.62356500
116PDPK10.58378079
117TAOK10.57864535
118PIK3CG0.56679843
119TAOK20.54544214
120PDGFRB0.54159920
121ZAK0.53984808
122DYRK1B0.53963247
123MKNK10.52790658
124MAP3K10.52713781
125LATS20.52593752
126RPS6KA20.52393396
127PTK2B0.52243696
128TAOK30.52171875
129TSSK60.51437074
130FRK0.51410402
131RET0.50810935
132PAK20.49283548
133LYN0.48903319
134PIK3CA0.48739447
135JAK30.48192394
136LRRK20.48138512
137MOS0.47587123
138MAPKAPK20.47122924
139WNK10.46508606
140JAK20.46344367
141NEK10.45122666
142PDK40.45072233
143PDK30.45072233
144MAPK70.44396045
145RAF10.43542636
146PLK30.43366576
147PRKAA10.43182414
148RPS6KA60.42764253
149RPS6KC10.42185475
150RPS6KL10.42185475
151FLT30.41682585
152KIT0.40763096
153RPS6KA10.40762463
154MAPK10.40252330
155CDK10.39277904
156PTK20.39197422

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.29840552
2RNA transport_Homo sapiens_hsa030132.13045041
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01492580
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97653842
5T cell receptor signaling pathway_Homo sapiens_hsa046601.96148537
6Primary immunodeficiency_Homo sapiens_hsa053401.95710459
7Base excision repair_Homo sapiens_hsa034101.84541217
8Selenocompound metabolism_Homo sapiens_hsa004501.74820558
9DNA replication_Homo sapiens_hsa030301.73511739
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72749963
11B cell receptor signaling pathway_Homo sapiens_hsa046621.62829304
12p53 signaling pathway_Homo sapiens_hsa041151.57059515
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55848730
14Chronic myeloid leukemia_Homo sapiens_hsa052201.54509846
15Herpes simplex infection_Homo sapiens_hsa051681.53370525
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48506477
17Homologous recombination_Homo sapiens_hsa034401.48489046
18Non-homologous end-joining_Homo sapiens_hsa034501.48449072
19Spliceosome_Homo sapiens_hsa030401.47138048
20mRNA surveillance pathway_Homo sapiens_hsa030151.45642591
21Inositol phosphate metabolism_Homo sapiens_hsa005621.44965694
22Small cell lung cancer_Homo sapiens_hsa052221.35553509
23Vitamin B6 metabolism_Homo sapiens_hsa007501.34172424
24Basal transcription factors_Homo sapiens_hsa030221.32971174
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.32656099
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.30655801
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30649917
28mTOR signaling pathway_Homo sapiens_hsa041501.29691699
29Mismatch repair_Homo sapiens_hsa034301.29575233
30Fanconi anemia pathway_Homo sapiens_hsa034601.26616182
31Renal cell carcinoma_Homo sapiens_hsa052111.25441142
32Osteoclast differentiation_Homo sapiens_hsa043801.24291126
33Leishmaniasis_Homo sapiens_hsa051401.22322014
34Dorso-ventral axis formation_Homo sapiens_hsa043201.21870446
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19767162
36Antigen processing and presentation_Homo sapiens_hsa046121.18308007
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17459682
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16100829
39MicroRNAs in cancer_Homo sapiens_hsa052061.13987767
40HTLV-I infection_Homo sapiens_hsa051661.13586700
41Lysine degradation_Homo sapiens_hsa003101.12964775
42Viral carcinogenesis_Homo sapiens_hsa052031.10839904
43RNA polymerase_Homo sapiens_hsa030201.10173986
44Epstein-Barr virus infection_Homo sapiens_hsa051691.09635493
45Acute myeloid leukemia_Homo sapiens_hsa052211.09081685
46Pancreatic cancer_Homo sapiens_hsa052121.08879736
47Influenza A_Homo sapiens_hsa051641.08183132
48Adherens junction_Homo sapiens_hsa045201.05936144
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02047444
50Toxoplasmosis_Homo sapiens_hsa051451.01159329
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99961872
52Choline metabolism in cancer_Homo sapiens_hsa052310.98943042
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97548525
54Non-small cell lung cancer_Homo sapiens_hsa052230.95670403
55Apoptosis_Homo sapiens_hsa042100.95623468
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95424416
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.94273900
58TNF signaling pathway_Homo sapiens_hsa046680.94119384
59ErbB signaling pathway_Homo sapiens_hsa040120.93669789
60Notch signaling pathway_Homo sapiens_hsa043300.93617208
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93172768
62Colorectal cancer_Homo sapiens_hsa052100.92649236
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92082799
64Hepatitis C_Homo sapiens_hsa051600.92042414
65FoxO signaling pathway_Homo sapiens_hsa040680.90793993
66Endocytosis_Homo sapiens_hsa041440.90590493
67Hepatitis B_Homo sapiens_hsa051610.90488438
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88435554
69One carbon pool by folate_Homo sapiens_hsa006700.88193150
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.86977456
71Chemokine signaling pathway_Homo sapiens_hsa040620.86777419
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86466450
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85236751
74Oocyte meiosis_Homo sapiens_hsa041140.85092384
75RNA degradation_Homo sapiens_hsa030180.85034935
76Thyroid cancer_Homo sapiens_hsa052160.84575482
77Endometrial cancer_Homo sapiens_hsa052130.83536863
78N-Glycan biosynthesis_Homo sapiens_hsa005100.83342167
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81873977
80Circadian rhythm_Homo sapiens_hsa047100.80845164
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80720411
82Legionellosis_Homo sapiens_hsa051340.79452274
83Prostate cancer_Homo sapiens_hsa052150.79344556
84TGF-beta signaling pathway_Homo sapiens_hsa043500.78928334
85Nucleotide excision repair_Homo sapiens_hsa034200.78875406
86Other glycan degradation_Homo sapiens_hsa005110.77905685
87Insulin resistance_Homo sapiens_hsa049310.77361713
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75995076
89Measles_Homo sapiens_hsa051620.75438666
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.75143607
91Prolactin signaling pathway_Homo sapiens_hsa049170.73352471
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73156210
93Proteoglycans in cancer_Homo sapiens_hsa052050.73004116
94Shigellosis_Homo sapiens_hsa051310.72278682
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72252243
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.71561744
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71451518
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.70528863
99VEGF signaling pathway_Homo sapiens_hsa043700.69912590
100Type II diabetes mellitus_Homo sapiens_hsa049300.69752137
101HIF-1 signaling pathway_Homo sapiens_hsa040660.67852565
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67412697
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.65812076
104Tuberculosis_Homo sapiens_hsa051520.65449016
105Pathways in cancer_Homo sapiens_hsa052000.62919001
106Focal adhesion_Homo sapiens_hsa045100.62428905
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62409562
108Hippo signaling pathway_Homo sapiens_hsa043900.60362221
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59573834
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58799586
111Platelet activation_Homo sapiens_hsa046110.58589140
112Estrogen signaling pathway_Homo sapiens_hsa049150.58148390
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58038200
114Amoebiasis_Homo sapiens_hsa051460.58006118
115Hematopoietic cell lineage_Homo sapiens_hsa046400.57474539
116Viral myocarditis_Homo sapiens_hsa054160.56643748
117MAPK signaling pathway_Homo sapiens_hsa040100.55898780
118Malaria_Homo sapiens_hsa051440.55437091
119Bladder cancer_Homo sapiens_hsa052190.55316221
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54243409
121Insulin signaling pathway_Homo sapiens_hsa049100.52525197
122GnRH signaling pathway_Homo sapiens_hsa049120.52115733
123Glioma_Homo sapiens_hsa052140.51693693
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.51341674
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.50299208
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49113584
127AMPK signaling pathway_Homo sapiens_hsa041520.49041100

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